Works (12)
Updated: July 25th, 2023 21:15
2011 journal article
A population genetic approach to mapping neurological disorder genes using deep resequencing
PLoS Genetics, 7(2).
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs
Nature Genetics, 42(3), 268–113.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents
BMC Evolutionary Biology, 8.
Source: NC State University Libraries
Added: August 6, 2018
2007 journal article
Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 155(2), 103–112.
author keywords: antigenic variation; malaria; Plasmodium falciparum; var genes
MeSH headings : Animals; Antigens, Protozoan / chemistry; Antigens, Protozoan / genetics; Antigens, Protozoan / immunology; Computational Biology / methods; DNA, Protozoan / chemistry; DNA, Protozoan / genetics; Female; Geography; Humans; Malaria / immunology; Malaria / parasitology; Malaria Vaccines / immunology; Models, Molecular; Molecular Sequence Data; Phylogeny; Plasmodium falciparum / genetics; Plasmodium falciparum / isolation & purification; Polymorphism, Genetic; Pregnancy; Pregnancy Complications, Parasitic / immunology; Pregnancy Complications, Parasitic / prevention & control; Protein Structure, Tertiary; Selection, Genetic; Sequence Analysis, DNA; Sequence Homology, Amino Acid
TL;DR:
A novel phylogenetic approach is developed that incorporates recombination and tracks new mutations in segment types in the VAR2CSA Duffy binding-like (DBL) adhesion domains and validate a new approach to modeling protein evolution in the presence of frequent recombination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection
BMC Genomics, 7.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome
NATURE GENETICS, 39(1), 126–130.
MeSH headings : Animals; Antigens, Protozoan / genetics; Antigens, Protozoan / isolation & purification; Antigens, Protozoan / metabolism; Cell-Free System / metabolism; Chromosome Mapping; Drug Delivery Systems; Drug Design; Drug Resistance / genetics; Genetic Variation; Genome, Protozoan; Humans; Immune Sera / chemistry; Malaria Vaccines / immunology; Malaria, Falciparum / immunology; Malaria, Falciparum / parasitology; Plasmodium falciparum / genetics; Plasmodium falciparum / immunology
TL;DR:
This work surveyed P. falciparum genes for polymorphisms and identified various highly polymorphic loci and genes, some of which encode new antigens that are confirmed using human immune sera and providing urgently needed vaccine candidates for disease control.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 148(2), 169–180.
author keywords: malaria; Plasmodium falciparum; antigenic variation; var genes
MeSH headings : Amino Acid Sequence; Animals; Antigenic Variation / genetics; Child; Evolution, Molecular; Female; Genes, Protozoan; Genetic Variation; Humans; Malaria, Falciparum / parasitology; Malaria, Falciparum / physiopathology; Molecular Sequence Data; Placenta / parasitology; Placenta Diseases / parasitology; Plasmodium falciparum / genetics; Plasmodium falciparum / immunology; Pregnancy; Pregnancy Complications, Parasitic / parasitology; Sequence Analysis, DNA; Severity of Illness Index
TL;DR:
The analysis of var genes in Plasmodium falciparum found that UpsA vars are highly diverse between 22 world-wide parasite isolates, although they could be grouped into two broad clusters that may be separately recombining.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Phenotypic variation and natural selection at Catsup, a pleiotropic quantitative trait gene in Drosphila
CURRENT BIOLOGY, 16(9), 912–919.
MeSH headings : Animals; Catecholamines / metabolism; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila Proteins / chemistry; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Molecular Sequence Data; Motor Activity / genetics; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic
TL;DR:
Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms and identify potentially functional variants in protein coding regions that have large effects and are not common.
(via Semantic Scholar)
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Recombination hotspots and population structure in Plasmodium falciparum
PLOS BIOLOGY, 3(10), 1734–1741.
MeSH headings : Africa; Animals; Asia, Southeastern; Central America; Drug Resistance; Genetics, Population; Linkage Disequilibrium / genetics; Papua New Guinea; Plasmodium falciparum / genetics; Polymorphism, Single Nucleotide; Recombination, Genetic / physiology; South America
TL;DR:
This study supports the feasibility of genome-wide association studies in some parasite populations by describing the first chromosome-wide SNP haplotype and population recombination maps for a global collection of malaria parasites, including the 3D7 isolate, whose genome has been sequenced previously.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 article
Darwinian selection on a selfing locus (Retracted Article. See vol 320, pg 176, 2008)
Shimizu, K. K., Cork, J. M., Caicedo, A. L., Mays, C. A., Moore, R. C., Olsen, K. M., … Purugganan, M. D. (2004, December 17). SCIENCE, Vol. 306, pp. 2081–2084.
MeSH headings : Alleles; Arabidopsis / genetics; Arabidopsis / physiology; Biological Evolution; Chromosome Mapping; Climate; DNA, Intergenic; Genes, Plant; Genetic Variation; Genome, Plant; Geography; Haplotypes; Likelihood Functions; Molecular Sequence Data; Open Reading Frames; Phylogeny; Plant Proteins; Pollen; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Protein Kinases / genetics; Protein Kinases / physiology; Pseudogenes; Recombination, Genetic; Selection, Genetic; Time
TL;DR:
Coalescent simulations indicate that ancillary morphological innovations associated with self-pollination can evolve rapidly after the inactivation of the self-incompatibility response, and suggest that the post-Pleistocene expansion of A. thaliana from glacial refugia may have been associated with this adaptive event.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
15. Life on Land
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
Functional divergence caused by ancient positive selection of a Drosophila hybrid incompatibility locus
PLoS Biology, 2(6), 839–848.
MeSH headings : Amino Acid Sequence; Animals; DNA Primers; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Genetics, Population; Hybridization, Genetic / genetics; Male; Models, Genetic; Molecular Sequence Data; Phylogeny; Reproduction / physiology; Reverse Transcriptase Polymerase Chain Reaction; Selection, Genetic; Sequence Alignment; Sequence Analysis, DNA; Species Specificity; Transgenes / genetics
TL;DR:
It is demonstrated that transgenic copies of the X-linked Hybrid male rescue (Hmr) gene have functionally diverged to cause F1 hybrid incompatibility between D. simulans and D. mauritiana, and it is suggested that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incomp compatibility alleles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Low linkage disequilibrium indicative of recombination in foot-and-mouth disease virus gene sequence alignments
JOURNAL OF GENERAL VIROLOGY, 85, 1095–1100.
MeSH headings : Capsid Proteins / genetics; Foot-and-Mouth Disease Virus / genetics; Genes, Viral; Linkage Disequilibrium; Recombination, Genetic; Sequence Analysis, RNA / methods
TL;DR:
Using the genealogical relationships, rate heterogeneity and mutation parameters estimated from individual sets of aligned gene sequences, matching RNA sequence datasets without recombination were simulated to allow for recurrent mutations at any site to mimic homoplasy in virus sequence data.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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