Philip Awadalla

Works (11)

Updated: October 14th, 2025 22:24

2011 journal article

A population genetic approach to mapping neurological disorder genes using deep resequencing

PLoS Genetics, 7(2).

By: R. Myers, F. Casals, J. Gauthier, F. Hamdan, J. Keebler, A. Boyko, C. Bustamante, A. Piton ...

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs

Nature Genetics, 42(3), 268–113.

By: J. Mu, R. Myers, H. Jiang, S. Liu, S. Ricklefs, M. Waisberg, K. Chotivanich, P. Wilairatana ...

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Selection shapes malaria genomes and drives divergence between pathogens infecting hominids versus rodents

BMC Evolutionary Biology, 8.

By: F. Prugnolle, K. Mcgee, J. Keebler & P. Awadalla

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Structural polymorphism and diversifying selection on the pregnancy malaria vaccine candidate VAR2CSA

Bockhorst, J., Lu, F., Janes, J. H., Keebler, J., Gamain, B., Awadalla, P., … Smith, J. D. (2007, June 27). Molecular and Biochemical Parasitology.

By: J. Bockhorst*, F. Lu*, J. Janes*, J. Keebler n, B. Gamain *, P. Awadalla n, X. Su *, R. Samudrala *, N. Jojic*, J. Smith *

author keywords: antigenic variation; malaria; Plasmodium falciparum; var genes
MeSH headings : Animals; Antigens, Protozoan / chemistry; Antigens, Protozoan / genetics; Antigens, Protozoan / immunology; Computational Biology / methods; DNA, Protozoan / chemistry; DNA, Protozoan / genetics; Female; Geography; Humans; Malaria / immunology; Malaria / parasitology; Malaria Vaccines / immunology; Models, Molecular; Molecular Sequence Data; Phylogeny; Plasmodium falciparum / genetics; Plasmodium falciparum / isolation & purification; Polymorphism, Genetic; Pregnancy; Pregnancy Complications, Parasitic / immunology; Pregnancy Complications, Parasitic / prevention & control; Protein Structure, Tertiary; Selection, Genetic; Sequence Analysis, DNA; Sequence Homology, Amino Acid
topics (OpenAlex): Malaria Research and Control; vaccines and immunoinformatics approaches; HIV Research and Treatment
TL;DR: A novel phylogenetic approach is developed that incorporates recombination and tracks new mutations in segment types in the VAR2CSA Duffy binding-like (DBL) adhesion domains and validate a new approach to modeling protein evolution in the presence of frequent recombination. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A murine specific expansion of the Rhox cluster involved in embryonic stem cell biology is under natural selection

BMC Genomics, 7.

By: M. Jackson, A. Watt, P. Gautier, D. Gilchrist, J. Driehaus, G. Graham, J. Keebler, F. Prugnolle, P. Awadalla, L. Forrester

Source: NC State University Libraries
Added: August 6, 2018

2006 article

Genome-wide variation and identification of vaccine targets in the Plasmodium falciparum genome

Mu, J., Awadalla, P., Duan, J., McGee, K. M., Keebler, J., Seydel, K., … Su, X.-zhuan. (2006, December 10). Nature Genetics.

By: J. Mu *, P. Awadalla n, J. Duan *, K. McGee n, J. Keebler n, K. Seydel *, G. McVean *, X. Su *

MeSH headings : Animals; Antigens, Protozoan / genetics; Antigens, Protozoan / isolation & purification; Antigens, Protozoan / metabolism; Cell-Free System / metabolism; Chromosome Mapping; Drug Delivery Systems; Drug Design; Drug Resistance / genetics; Genetic Variation; Genome, Protozoan; Humans; Immune Sera / chemistry; Malaria Vaccines / immunology; Malaria, Falciparum / immunology; Malaria, Falciparum / parasitology; Plasmodium falciparum / genetics; Plasmodium falciparum / immunology
topics (OpenAlex): Malaria Research and Control; vaccines and immunoinformatics approaches; Mosquito-borne diseases and control
TL;DR: This work surveyed P. falciparum genes for polymorphisms and identified various highly polymorphic loci and genes, some of which encode new antigens that are confirmed using human immune sera and providing urgently needed vaccine candidates for disease control. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 article

Global genetic diversity and evolution of var genes associated with placental and severe childhood malaria

Trimnell, A. R., Kraemer, S. M., Mukherjee, S., Phippard, D. J., Janes, J. H., Flamoe, E., … Smith, J. D. (2006, April 19). Molecular and Biochemical Parasitology.

By: A. Trimnell*, S. Kraemer*, S. Mukherjee *, D. Phippard*, J. Janes*, E. Flamoe*, X. Su *, P. Awadalla n, J. Smith *

author keywords: malaria; Plasmodium falciparum; antigenic variation; var genes
MeSH headings : Amino Acid Sequence; Animals; Antigenic Variation / genetics; Child; Evolution, Molecular; Female; Genes, Protozoan; Genetic Variation; Humans; Malaria, Falciparum / parasitology; Malaria, Falciparum / physiopathology; Molecular Sequence Data; Placenta / parasitology; Placenta Diseases / parasitology; Plasmodium falciparum / genetics; Plasmodium falciparum / immunology; Pregnancy; Pregnancy Complications, Parasitic / parasitology; Sequence Analysis, DNA; Severity of Illness Index
topics (OpenAlex): Malaria Research and Control; Mosquito-borne diseases and control; Complement system in diseases
TL;DR: The analysis of var genes in Plasmodium falciparum found that UpsA vars are highly diverse between 22 world-wide parasite isolates, although they could be grouped into two broad clusters that may be separately recombining. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 article

Phenotypic Variation and Natural Selection at Catsup, a Pleiotropic Quantitative Trait Gene in Drosophila

Carbone, M. A., Jordan, K. W., Lyman, R. F., Harbison, S. T., Leips, J., Morgan, T. J., … Mackay, T. F. C. (2006, May 1). Current Biology, Vol. 16, pp. 912–919.

By: M. Carbone n , K. Jordan n, R. Lyman n, S. Harbison  n, J. Leips*, T. Morgan n, M. DeLuca n, P. Awadalla n, T. Mackay n

MeSH headings : Animals; Catecholamines / metabolism; Drosophila / anatomy & histology; Drosophila / genetics; Drosophila Proteins / chemistry; Drosophila Proteins / genetics; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / genetics; Female; Genetic Variation; Genotype; Longevity / genetics; Male; Molecular Sequence Data; Motor Activity / genetics; Phenotype; Quantitative Trait Loci; Quantitative Trait, Heritable; Selection, Genetic
topics (OpenAlex): Insect symbiosis and bacterial influences; Genetic Mapping and Diversity in Plants and Animals; Insect Resistance and Genetics
TL;DR: Molecular population genetic analyses of Catsup sequences are consistent with balancing selection maintaining multiple functional polymorphisms and identify potentially functional variants in protein coding regions that have large effects and are not common. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2005 article

Recombination Hotspots and Population Structure in Plasmodium falciparum

Mu, J., Awadalla, P., Duan, J., McGee, K. M., Joy, D. A., McVean, G. A. T., & Su, X.-zhuan. (2005, September 6). PLoS Biology.

By: J. Mu *, P. Awadalla n, J. Duan *, K. McGee n, D. Joy*, G. McVean *, X. Su *

MeSH headings : Africa; Animals; Asia, Southeastern; Central America; Drug Resistance; Genetics, Population; Linkage Disequilibrium / genetics; Papua New Guinea; Plasmodium falciparum / genetics; Polymorphism, Single Nucleotide; Recombination, Genetic / physiology; South America
topics (OpenAlex): Malaria Research and Control; Evolution and Genetic Dynamics; HIV Research and Treatment
TL;DR: This study supports the feasibility of genome-wide association studies in some parasite populations by describing the first chromosome-wide SNP haplotype and population recombination maps for a global collection of malaria parasites, including the 3D7 isolate, whose genome has been sequenced previously. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 article

Functional Divergence Caused by Ancient Positive Selection of a Drosophila Hybrid Incompatibility Locus

Barbash, D. A., Awadalla, P., & Tarone, A. M. (2004, June 9). PLoS Biology.

By: D. Barbash*, P. Awadalla n & A. Tarone *

MeSH headings : Amino Acid Sequence; Animals; DNA Primers; Drosophila Proteins / genetics; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Genetics, Population; Hybridization, Genetic / genetics; Male; Models, Genetic; Molecular Sequence Data; Phylogeny; Reproduction / physiology; Reverse Transcriptase Polymerase Chain Reaction; Selection, Genetic; Sequence Alignment; Sequence Analysis, DNA; Species Specificity; Transgenes / genetics
topics (OpenAlex): Animal Behavior and Reproduction; Plant and animal studies; Evolution and Genetic Dynamics
TL;DR: It is demonstrated that transgenic copies of the X-linked Hybrid male rescue (Hmr) gene have functionally diverged to cause F1 hybrid incompatibility between D. simulans and D. mauritiana, and it is suggested that multiple substitutions driven by natural selection may be a general phenomenon required to generate hybrid incomp compatibility alleles. (via Semantic Scholar)
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15. Life on Land (Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2004 article

Low linkage disequilibrium indicative of recombination in foot-and-mouth disease virus gene sequence alignments

Haydon, D. T., Bastos, A. D. S., & Awadalla, P. (2004, April 22). Journal of General Virology.

By: D. Haydon *, A. Bastos * & P. Awadalla n

MeSH headings : Capsid Proteins / genetics; Foot-and-Mouth Disease Virus / genetics; Genes, Viral; Linkage Disequilibrium; Recombination, Genetic; Sequence Analysis, RNA / methods
topics (OpenAlex): Animal Disease Management and Epidemiology; Viral Infections and Immunology Research; RNA and protein synthesis mechanisms
TL;DR: Using the genealogical relationships, rate heterogeneity and mutation parameters estimated from individual sets of aligned gene sequences, matching RNA sequence datasets without recombination were simulated to allow for recurrent mutations at any site to mimic homoplasy in virus sequence data. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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