Prasad Uday Bandodkar
College of Engineering
Works (4)
Updated: July 5th, 2023 14:53
2020 journal article
Robustness of the Dorsal morphogen gradient with respect to morphogen dosage
PLOS COMPUTATIONAL BIOLOGY, 16(4).
MeSH headings : Animals; Body Patterning / genetics; Cell Nucleus / metabolism; Cytoplasm / metabolism; DNA-Binding Proteins / metabolism; Drosophila / embryology; Drosophila / genetics; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Embryo, Nonmammalian / metabolism; Gene Expression Regulation, Developmental / genetics; Morphogenesis / genetics; NF-kappa B / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism; Signal Transduction; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
The robustness of the Dorsal/NF-κB signaling module with respect to perturbations to the dosage of maternally-expressed dorsal mRNA is investigated and the need for quantitative understanding of biophysical mechanisms of morphogen gradients in order to understand emergent phenotypes, such as robustness is highlighted.
(via Semantic Scholar)
open access via journals.plos.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 26, 2020
2020 journal article
Spatiotemporal control of gene expression boundaries using a feedforward loop
DEVELOPMENTAL DYNAMICS, 249(3), 369–382.
author keywords: dorsal morphogen; Drosophila embryo; feedforward loop; gene expression model; spatiotemporal dynamics; transcription factor; Twist; Zelda
MeSH headings : Animals; Body Patterning / genetics; Body Patterning / physiology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Embryo, Nonmammalian / metabolism; Gene Expression Regulation, Developmental / genetics; Gene Expression Regulation, Developmental / physiology; NF-kappa B / metabolism; Signal Transduction / genetics; Signal Transduction / physiology
TL;DR:
This work studied the spatiotemporal behavior of a coherent FFL in two contexts: a generic, oscillating morphogen gradient and the dorsal-ventral patterning of the early Drosophila embryo by a gradient of the NF-κB homolog Dorsal with its early target Twist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: February 3, 2020
2020 article
Spatiotemporal control of gene expression boundaries using a feedforward loop
Reeves, G., Bandodkar, P., & Al Asafen, H. (2020, April). FASEB JOURNAL, Vol. 34.
TL;DR:
This work studied the spatiotemporal behavior of a coherent FFL in two contexts: a generic, oscillating morphogen gradient and the dorsal‐ventral patterning of the early Drosophila embryo by a gradient of the NF‐κB homolog Dorsal with its early target Twist.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: October 12, 2020
2019 article
Formation, interpretation, and regulation of the Drosophila Dorsal/NF-kappa B gradient
GRADIENTS AND TISSUE PATTERNING, Vol. 137, pp. 143–191.
MeSH headings : Animals; Body Patterning; Computational Biology / methods; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / embryology; Drosophila melanogaster / physiology; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / physiology; Gene Expression Regulation, Developmental; NF-kappa B / genetics; NF-kappa B / metabolism; Nuclear Proteins / genetics; Nuclear Proteins / metabolism; Phosphoproteins / genetics; Phosphoproteins / metabolism; Signal Transduction; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
The mechanisms behind the initiation of the Dorsal gradient and its regulation of target genes are described, and a discussion of quantitative and computational studies ofThe Dl gradient system, including regulation of theDl gradient is discussed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: May 26, 2020