@article{spriggs_gedon_linder_bizikova_2024, title={Comparison of selected cytomorphological features of canine pemphigus foliaceus and superficial pyoderma}, ISSN={["1365-3164"]}, DOI={10.1111/vde.13267}, abstractNote={Abstract Background Cytological detection of acantholytic keratinocytes (acantholytic cells [AC]) helps to identify canine pemphigus foliaceus (cPF) yet AC also occurs in superficial pyoderma (SP), the main differential diagnosis. Hypothesis/Objectives To compare selected cytomorphological features of cPF and SP and to establish cytological diagnostic criteria that could differentiate cPF from SP. Animals 40 and 51 client‐owned dogs with PF and SP, respectively. Materials and Methods Impression smears from cPF (64), impetigo (40) and exfoliative superficial pyoderma (ESP) (17) samples were stained with Romanowsky stain, randomised, blinded and evaluated by two investigators independently. The entire sample was screened (×500 or ×1000 magnification) for round (AC1), boat (AC2) and raft AC, eosinophils and bacteria. Interobserver agreements were calculated. Results The average number of the 10 highest ×500 fields for AC1 and AC2 was significantly higher in PF than SP ( p < 0.0001; Kruskal–Wallis test). Rafts and eosinophils were more common in PF than SP ( p < 0.0001; chi‐square test), while bacteria were rare in PF (5%; p < 0.0001; chi‐square test). Observations between the experienced and novice investigators were highly correlated. An ROC analysis identified five AC1/×500‐magnification field as a suitable cut‐off value for predicting PF diagnosis. This cut‐off value was tested by two additional investigators, who identified sensitivity of 84%–100%, specificity of 95%–97% and accuracy of 95%–96% for the diagnosis of cPF. Conclusions and Clinical Relevance Criterion‐based impression smear cytological evaluation can provide strong evidence to support the clinical diagnosis. Acantholytic cell morphology varies in cPF and SP, and experience can improve accuracy in cytological differentiation.}, journal={VETERINARY DERMATOLOGY}, author={Spriggs, Tyler S. and Gedon, Natalie K. Y. and Linder, Keith E. and Bizikova, Petra}, year={2024}, month={Jun} }
 @article{jordan_mamo_olivry_liu_bizikova_2024, title={Re-evaluating the prevalence of anti-desmocollin-1 IgA autoantibodies in canine pemphigus foliaceus}, volume={273}, ISSN={["1873-2534"]}, DOI={10.1016/j.vetimm.2024.110773}, abstractNote={Pemphigus foliaceus (PF) is an autoimmune skin disease of dogs characterized by intraepidermal pustules containing neutrophils and dissociated keratinocytes that develop in association with circulating and tissue-bound IgG autoantibodies. A subset of IgG autoantibodies in canine PF target desmocollin-1 (DSC1), a component of intercellular adhesion complexes within the epidermis. Passive transfer of IgG autoantibodies from canine PF sera to mice was previously shown to induce skin disease in the absence of infiltrating neutrophils. In attempts to identify a mechanism responsible for neutrophil recruitment, past studies evaluated the prevalence of IgA autoantibodies in canine PF sera where they were found in <20% of affected dogs. We re-evaluated the prevalence of anti-DSC1 IgA in canine PF due to concerns regarding the sensitivity of previously used methods. We hypothesized that anti-DSC1 IgA are present in most dogs with PF but have been under-detected due to competition with concurrent anti-DSC1 IgG for binding to their mutual antigenic target. Despite removing approximately 80% of IgG from patient sera using affinity chromatography, we did not detect an increase in anti-DSC1 IgA by performing indirect immunofluorescence on canine DSC1-transfected HEK293T cells. Taken together, our results do not support a role for pathogenic IgA in canine PF.}, journal={VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY}, author={Jordan, Tyler J. M. and Mamo, Lisa B. and Olivry, Thierry and Liu, Zhi and Bizikova, Petra}, year={2024}, month={Jul} }
 @article{bizikova_linder_anderson_2023, title={Erosive and ulcerative stomatitis in dogs and cats: which immune-mediated diseases to consider?}, volume={261}, ISSN={["1943-569X"]}, DOI={10.2460/javma.22.12.0573}, abstractNote={Abstract}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Bizikova, Petra and Linder, Keith E. and Anderson, Jamie G.}, year={2023}, month={Jun}, pages={S48–S57} }
 @article{gedon_bizikova_olivry_mendoza-kuznetsova_oberkirchner_robertson_linder_2023, title={Histopathological characterisation of trunk-dominant canine pemphigus foliaceus, and comparison with classic facial and insecticide-triggered forms}, volume={6}, ISSN={["1365-3164"]}, url={https://doi.org/10.1111/vde.13174}, DOI={10.1111/vde.13174}, abstractNote={Abstract}, journal={VETERINARY DERMATOLOGY}, author={Gedon, Natalie Katharina Yvonne and Bizikova, Petra and Olivry, Thierry and Mendoza-Kuznetsova, Ekaterina and Oberkirchner, Ursula and Robertson, James Benjamin and Linder, Keith Emerson}, year={2023}, month={Jun} }
 @misc{bizikova_olivry_linder_rybnicek_2023, title={Spontaneous autoimmune subepidermal blistering diseases in animals: a comprehensive review}, volume={19}, ISSN={["1746-6148"]}, url={https://doi.org/10.1186/s12917-023-03597-1}, DOI={10.1186/s12917-023-03597-1}, abstractNote={Abstract}, number={1}, journal={BMC VETERINARY RESEARCH}, author={Bizikova, Petra and Olivry, Thierry and Linder, Keith and Rybnicek, Jan}, year={2023}, month={Feb} }
 @article{herrmann_mamo_holmes_mohammed_murphy_bizikova_2022, title={Long-term effects of ciclosporin and oclacitinib on mediators of tolerance, regulatory T-cells, IL-10 and TGF-beta, in dogs with atopic dermatitis}, ISSN={["1365-3164"]}, DOI={10.1111/vde.13140}, abstractNote={Abstract}, journal={VETERINARY DERMATOLOGY}, author={Herrmann, Ina and Mamo, Lisa B. and Holmes, Jenny and Mohammed, Javid P. and Murphy, K. Marcia and Bizikova, Petra}, year={2022}, month={Dec} }
 @article{bizikova_linder_mamo_2022, title={Trunk-dominant and classic facial pemphigus foliaceus in dogs - comparison of anti-desmocollin-1 and anti-desmoglein-1 autoantibodies and clinical presentations}, ISSN={["1365-3164"]}, DOI={10.1111/vde.13094}, abstractNote={Abstract}, journal={VETERINARY DERMATOLOGY}, author={Bizikova, Petra and Linder, Keith E. and Mamo, Lisa B.}, year={2022}, month={Jun} }
 @article{fussell_bizikova_breuhaus_harris_moore_chen_linder_2021, title={Bullous amyloidosis in a horse: first description in veterinary medicine}, volume={6}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12982}, abstractNote={BackgroundBullous amyloidosis is a rare disease in humans that has not been described in a veterinary species in the peer‐reviewed literature. The human disease is characterised by haemorrhagic vesicles and bullae on the skin and mucosae, which form due to amyloid deposition.}, journal={VETERINARY DERMATOLOGY}, author={Fussell, Devin and Bizikova, Petra and Breuhaus, Babetta and Harris, R. Adam and Moore, A. Russell and Chen, Laura and Linder, Keith E.}, year={2021}, month={Jun} }
 @article{herrmann_linder_meurs_friedenberg_cullen_olby_bizikova_2021, title={Canine junctional epidermolysis bullosa due to a novel mutation in LAMA3 with severe upper respiratory involvement}, volume={32}, ISSN={["1365-3164"]}, url={https://doi.org/10.1111/vde.12972}, DOI={10.1111/vde.12972}, abstractNote={BackgroundJunctional epidermolysis bullosa (JEB) is a group of congenital blistering skin diseases characterized by clefting through the lamina lucida of the basement membrane zone.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={Herrmann, Ina and Linder, Keith E. and Meurs, Kathryn M. and Friedenberg, Steven G. and Cullen, Jonah and Olby, Natasha and Bizikova, Petra}, year={2021}, month={Aug}, pages={379-+} }
 @article{halliwell_pucheu-haston_olivry_prost_jackson_banovic_nuttall_santoro_bizikova_mueller_2021, title={Feline allergic diseases: introduction and proposed nomenclature}, volume={32}, ISBN={1365-3164}, url={https://doi.org/10.1111/vde.12899}, DOI={10.1111/vde.12899}, abstractNote={BackgroundFeline allergic diseases present as challenging problems for clinicians, not least because of the number of reaction patterns of the feline skin, none of which are specific for allergy. Furthermore, there is some controversy over the nomenclature that should be used in their description.}, number={1}, journal={VETERINARY DERMATOLOGY}, publisher={Wiley}, author={Halliwell, Richard and Pucheu-Haston, Cherie M. and Olivry, Thierry and Prost, Christine and Jackson, Hilary and Banovic, Frane and Nuttall, Tim and Santoro, Domenico and Bizikova, Petra and Mueller, Ralf S.}, year={2021}, month={Feb}, pages={8-+} }
 @article{didomenico_fowler_horne_bizikova_schnabel_stowe_2021, title={Pathology in Practice}, volume={258}, ISSN={0003-1488}, url={http://dx.doi.org/10.2460/javma.258.9.961}, DOI={10.2460/javma.258.9.961}, number={9}, journal={Journal of the American Veterinary Medical Association}, publisher={American Veterinary Medical Association (AVMA)}, author={DiDomenico, Amy E. and Fowler, Alexander W. and Horne, Caitlyn R. and Bizikova, Petra and Schnabel, Lauren V. and Stowe, Devorah M.}, year={2021}, month={May}, pages={961–964} }
 @misc{mueller_nuttall_prost_schulz_bizikova_2021, title={Treatment of the feline atopic syndrome - a systematic review}, volume={32}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12933}, abstractNote={BackgroundFeline allergic skin disease and asthma occur regularly in small animal practice.}, number={1}, journal={VETERINARY DERMATOLOGY}, author={Mueller, Ralf S. and Nuttall, Tim and Prost, Christine and Schulz, Bianka and Bizikova, Petra}, year={2021}, month={Feb}, pages={43-+} }
 @article{levy_linder_mamo_herrmann_bizikova_2020, title={Cutaneous polyautoimmunity in two unrelated dogs: pemphigus foliaceus and generalized discoid lupus erythematosus}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12851}, abstractNote={BackgroundPolyautoimmunity, the concurrent expression of two or more distinct autoimmune diseases (ADs) in a single individual, is a known phenomenon in humans and has been rarely reported in dogs. To the best of the authors’ knowledge, comorbid pemphigus foliaceus (PF) and generalized discoid lupus erythematosus (GDLE) has not been reported in dogs.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={Levy, Britt J. and Linder, Keith E. and Mamo, Lisa B. and Herrmann, Ina and Bizikova, Petra}, year={2020}, month={Aug}, pages={325-+} }
 @article{levy_mamo_bizikova_2020, title={Detection of circulating anti-keratinocyte autoantibodies in feline pemphigus foliaceus}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12861}, abstractNote={BackgroundCirculating anti‐keratinocyte immunoglobulin (Ig)G targeting desmosomal proteins have been identified in people and dogs with pemphigus foliaceus (PF). By contrast, detection attempts in PF‐affected cats have been largely unsuccessful.}, number={5}, journal={VETERINARY DERMATOLOGY}, author={Levy, Britt J. and Mamo, Lisa B. and Bizikova, Petra}, year={2020}, month={Oct}, pages={378-+} }
 @article{mowat_avelino_bowyer_parslow_westermeyer_foster_fogle_bizikova_2020, title={Detection of circulating anti-retinal antibodies in dogs with sudden acquired retinal degeneration syndrome using indirect immunofluorescence: A case control study}, volume={193}, ISSN={["1096-0007"]}, DOI={10.1016/j.exer.2020.107989}, abstractNote={Sudden acquired retinal degeneration syndrome (SARDS) in dogs is proposed to have an immune-mediated etiology. However, there is conflicting evidence regarding the presence of antiretinal antibodies, as assessed by western blotting, in the serum of SARDS patients. Because of the possibility that antibodies recognize only conformational epitopes, we hypothesized that a more sensitive method to investigate circulating retinal autoantibodies in SARDS is immunofluorescence. Sera from 14 dogs with early SARDS, and 14 age- and breed-matched healthy control dogs were screened for circulating antiretinal IgG, IgM, IgE and IgA using indirect immunofluorescence on lightly fixed frozen sections of normal canine retina. Controls without canine serum were also performed. A nuclear counterstain was used to identify cellular retinal layers. Images were obtained using a fluorescence microscope, and 2-3 separate masked observers graded retinal layers for fluorescence staining intensity using a 0–3 scale. Total circulating IgG and IgM was assessed by radial immunodiffusion. Statistical analysis was performed using 2-way ANOVA, paired 2-tailed student's t-test and correlation analysis. Intensity of IgG staining of photoreceptor outer segments was significantly higher using serum from dogs with SARDS compared with healthy controls in 2/3 observers (P < 0.05). Intensity of IgM staining throughout the retina was higher in SARDS dogs compared to matched healthy controls (P < 0.0001), although no specific retinal layer was statistically significant. There were no differences in staining intensity for IgE or IgA. Dogs with SARDS had a comparably lower circulating IgG and higher IgM than healthy controls (P = 0.01 and 0.001 respectively) and IgG and IgM were negatively correlated (r = −0.69, P = 0.007). Despite having decreased serum IgG compared with healthy controls, circulating IgG in dogs with SARDS binds photoreceptor outer segments to a greater extent. Dogs with SARDS have a relatively higher circulating IgM than matched healthy controls. The pathogenic nature of these antibodies is unknown.}, journal={EXPERIMENTAL EYE RESEARCH}, author={Mowat, Freya M. and Avelino, Janelle and Bowyer, Ashley and Parslow, Vanessa and Westermeyer, Hans D. and Foster, Melanie L. and Fogle, Jonathan E. and Bizikova, Petra}, year={2020}, month={Apr} }
 @article{goodale_varjonen_outerbridge_bizikova_borjesson_murrell_bisconte_francesco_hill_masjedizadeh_et al._2020, title={Efficacy of a Bruton's Tyrosine Kinase Inhibitor (PRN-473) in the treatment of canine pemphigus foliaceus}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12841}, abstractNote={BackgroundBruton's tyrosine kinase (BTK) is important in B‐cell signalling. Efficacy has been reported for BTK inhibitors (BTKi) in human autoimmune diseases. Canine pemphigus foliaceus (cPF) is the most common canine autoimmune skin disease.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={Goodale, Elizabeth C. and Varjonen, Katarina E. and Outerbridge, Catherine A. and Bizikova, Petra and Borjesson, Dori and Murrell, Dedee F. and Bisconte, Angelina and Francesco, Michelle and Hill, Ronald J. and Masjedizadeh, Mohammad and et al.}, year={2020}, month={Aug}, pages={291-+} }
 @article{anderson_kol_bizikova_stapelton_ford_villarreal_jimenez_vasilatis_murphy_2020, title={Immunopathogenesis of canine chronic ulcerative stomatitis}, volume={15}, ISSN={["1932-6203"]}, DOI={10.1371/journal.pone.0227386}, abstractNote={Canine Chronic Ulcerative Stomatitis is a spontaneously occurring inflammatory disease of the oral mucosa. An immune-mediated pathogenesis is suspected though not yet proven. We have recently reported on the clinical and histologic features, and identification of select leukocyte cell populations within the lesion. A clinical and histologic similarity to oral lichen planus of people was proposed. In the present study, these initial observations are extended by examining lesions from 24 dogs with clinical evidence of chronic ulcerative stomatitis. Because dogs with chronic ulcerative stomatitis often have concurrent periodontal disease, we wondered if dental plaque/biofilm may be a common instigator of inflammation in both lesions. We hypothesized that dogs with chronic ulcerative stomatitis would exhibit a spectrum of pathologic changes and phenotype of infiltrating leukocytes that would inform lesion pathogenesis and that these changes would differ from inflammatory phenotypes in periodontitis. Previously we identified chronic ulcerative stomatitis lesions to be rich in FoxP3+ and IL17+ cells. As such, we suspect that these leukocytes play an important role in lesion pathogenesis. The current study confirms the presence of moderate to large numbers of FoxP3+ T cells and IL17+ cells in all ulcerative stomatitis lesions using confocal immunofluorescence. Interestingly, the majority of IL17+ cells were determined to be non-T cells and IL17+ cell frequencies were negatively correlated with severity on the clinical scoring system. Three histologic subtypes of ulcerative stomatitis were determined; lichenoid, deep stomatitis and granulomatous. Periodontitis lesions, like stomatitis lesions, were B cell and plasma cell rich, but otherwise differed from the stomatitis lesions. Direct immunofluorescence results did not support an autoantibody-mediated autoimmune disease process. This investigation contributes to the body of literature regarding leukocyte involvement in canine idiopathic inflammatory disease pathogenesis.}, number={1}, journal={PLOS ONE}, author={Anderson, J. G. and Kol, A. and Bizikova, P. and Stapelton, B. P. and Ford, K. and Villarreal, A. and Jimenez, R. J. and Vasilatis, D. and Murphy, B. G.}, year={2020}, month={Jan} }
 @article{goodale_white_bizikova_borjesson_murrell_bisconte_francesco_hill_masjedizadeh_nunn_et al._2020, title={Open trial of Bruton's tyrosine kinase inhibitor (PRN1008) in the treatment of canine pemphigus foliaceus}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12878}, abstractNote={Résumé}, number={5}, journal={VETERINARY DERMATOLOGY}, author={Goodale, Elizabeth C. and White, Stephen D. and Bizikova, Petra and Borjesson, Dori and Murrell, Dedee F. and Bisconte, Angelina and Francesco, Michelle and Hill, Ronald J. and Masjedizadeh, Mohammad and Nunn, Philip and et al.}, year={2020}, month={Oct}, pages={410-+} }
 @article{high_linder_mamo_levy_herrmann_bizikova_2020, title={Rapid response of hyperkeratotic erythema multiforme to oclacitinib in two dogs}, volume={31}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12852}, abstractNote={BackgroundHyperkeratotic erythema multiforme (HKEM) is a clinically distinct dermatosis and poorly characterized syndrome, comprised of hyperkeratotic plaques with variable symmetry and apoptosis similar to “classic” erosive canine EM. Hyperkeratotic EM has a protracted clinical course and, although treatments with glucocorticoids, azathioprine and/or ciclosporin have been tried, rates of remission are low.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={High, Endya J. and Linder, Keith E. and Mamo, Lisa B. and Levy, Britt J. and Herrmann, Ina and Bizikova, Petra}, year={2020}, month={Aug}, pages={330-+} }
 @misc{bizikova_burrows_2019, title={Feline pemphigus foliaceus: original case series and a comprehensive literature review}, volume={15}, ISSN={["1746-6148"]}, DOI={10.1186/s12917-018-1739-y}, abstractNote={Since the first description of feline pemphigus foliaceus (PF) more than 30 years ago, numerous case reports have been published, while larger case series have remained rare. This large body of information, if extrapolated, could address clinical discrepancies and expand our knowledge about the treatment of feline PF. This manuscript reviews cases of feline PF published between 1950 and 2016 and adds additional 35 original cases to provide further insight into the clinical aspect and treatment outcome of this disease. Feline PF, while being a primary acantholytic pustular dermatosis, presents most often with crusts and erosions that predominantly affect the face and feet. More than half of cats with active disease exhibits non-dermatological signs such as lethargy, fever and/or anorexia. The prognosis of feline PF is good as the majority of cats rapidly achieve disease control even with the most basic treatment such as glucocorticoid monotherapy. Most PF-affected cats, however, require long-term treatment and, like other autoimmune diseases, feline PF has a tendency to relapse spontaneously or with treatment changes. Therefore, despite the overall good prognosis cats with PF can be given, owners should be informed and prepared for these circumstances, which may reduce the risk of euthanasia in the case of disease relapse, and improve treatment compliance.}, journal={BMC VETERINARY RESEARCH}, author={Bizikova, Petra and Burrows, Amanda}, year={2019}, month={Jan} }
 @article{linder_bizikova_luff_zhou_yuan_breuhaus_nelson_mackay_2018, title={Generalized papillomatosis in three horses associated with a novel equine papillomavirus (EcPV8)}, volume={29}, number={1}, journal={Veterinary Dermatology}, author={Linder, K. E. and Bizikova, P. and Luff, J. and Zhou, D. and Yuan, H. and Breuhaus, B. and Nelson, E. and Mackay, R.}, year={2018} }
 @article{golly_breitschwerdt_balakrishnan_moore_bizikova_2017, title={Bartonella henselae, Bartonella koehlerae and Rickettsia rickettsii seroconversion and seroreversion in a dog with acute-onset fever, lameness, and lymphadenopathy followed by a protracted disease course}, volume={7}, ISSN={2405-9390}, url={http://dx.doi.org/10.1016/J.VPRSR.2016.12.002}, DOI={10.1016/J.VPRSR.2016.12.002}, abstractNote={Following recent tick exposure in Arkansas, a 2-year-old, female spayed Labradoodle was examined because of a one-week history of lethargy and shifting-leg lameness. The dog was febrile, had prominent lymph nodes, dull mentation, a stiff gait, and left forelimb lameness. Thrombocytopenia was the only initial hematological or biochemical abnormality. Despite treatment with doxycycline for suspected Rocky Mountain spotted fever, the dog continued to have waxing and waning clinical signs including inappetence, fever, shifting-leg lameness, lymphadenopathy, splenomegaly, and weight loss in association with moderate to severe hematological abnormalities, including anemia, thrombocytopenia, neutrophilia, and monocytosis. Sequential serological testing confirmed Bartonella henselae, Bartonella koehlerae and R. rickettsii seroconversion. Doxycycline, enrofloxacin and clarithromycin were administered in sequential combination for treatment of rickettsioses, B. henselae and B. koehlerae. Prednisone, thyroid supplementation and other drugs were administered to elicit symptomatic improvement. Based upon seroreversion, and the eventual resolution of all clinical and hematological abnormalities, therapeutic elimination of all three pathogens was seemingly achieved. Whether cortisol insufficiency due to adrenal exhaustion syndrome or post-infectious immune-mediated sequelae contributed to the symptoms and pathophysiological abnormalities reported in this dog was not determined, but are considerations for future cases.}, journal={Veterinary Parasitology: Regional Studies and Reports}, publisher={Elsevier BV}, author={Golly, Elizabeth and Breitschwerdt, Edward B. and Balakrishnan, Nandhakumar and Moore, Deedee and Bizikova, Petra}, year={2017}, month={Jan}, pages={19–24} }
 @article{levine_cianciolo_linder_bizikova_birkenheuer_brooks_salous_nordone_bellinger_marr_et al._2017, title={Endothelial alterations in a canine model of immune thrombocytopenia}, volume={30}, ISSN={0953-7104 1369-1635}, url={http://dx.doi.org/10.1080/09537104.2017.1378807}, DOI={10.1080/09537104.2017.1378807}, abstractNote={Abstract Bleeding heterogeneity amongst patients with immune thrombocytopenia (ITP) is poorly understood. Platelets play a role in maintaining endothelial integrity, and variable thrombocytopenia-induced endothelial changes may influence bleeding severity. Platelet-derived endothelial stabilizers and markers of endothelial integrity in ITP are largely underexplored. We hypothesized that, in a canine ITP model, thrombocytopenia would lead to alterations in the endothelial ultrastructure and that the Von Willebrand factor (vWF) would serve as a marker of endothelial injury associated with thrombocytopenia. Thrombocytopenia was induced in healthy dogs with an antiplatelet antibody infusion; control dogs received an isotype control antibody. Cutaneous biopsies were obtained prior to thrombocytopenia induction, at platelet nadir, 24 hours after nadir, and on platelet recovery. Cutaneous capillaries were assessed by electron microscopy for vessel thickness, the number of pinocytotic vesicles, the number of large vacuoles, and the number of gaps between cells. Pinocytotic vesicles are thought to represent an endothelial membrane reserve that can be used for repair of damaged endothelial cells. Plasma samples were assessed for vWF. ITP dogs had significantly decreased pinocytotic vesicle numbers compared to control dogs (P = 0.0357) and the increase in plasma vWF from baseline to 24 hours correlated directly with the endothelial large vacuole score (R = 0.99103; P < 0.0001). This direct correlation between plasma vWF and the number of large vacuoles, representing the vesiculo-vacuolar organelle (VVO), a permeability structure, suggests that circulating vWF could serve as a biomarker for endothelial alterations and potentially a predictor of thrombocytopenic bleeding. Overall, our results indicate that endothelial damage occurs in the canine ITP model and variability in the degree of endothelial damage may account for differences in the bleeding phenotype among patients with ITP.}, number={1}, journal={Platelets}, publisher={Informa UK Limited}, author={LeVine, Dana N. and Cianciolo, Rachel E. and Linder, Keith E. and Bizikova, Petra and Birkenheuer, Adam J. and Brooks, Marjory B. and Salous, Abdelghaffar K. and Nordone, Shila K. and Bellinger, Dwight A. and Marr, Henry and et al.}, year={2017}, month={Nov}, pages={88–97} }
 @article{adamovicz_kennedy-stoskopf_talley_cullen_cohen_bizikova_grunkemeyer_2017, title={MYCOBACTERIUM INTRACELLULARE INFECTION CAUSING A RETROPERITONEAL MASS IN A BINTURONG (ARCTICTIS BINTURONG)}, volume={48}, ISSN={["1937-2825"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-85026496685&partnerID=MN8TOARS}, DOI={10.1638/2016-0117r.1}, abstractNote={Abstract A 19-yr-old castrated male binturong (Arctictis binturong) with a history of recurrent pyogranulomatous panniculitis, lymphangitis, and dermatitis was presented for evaluation of hyporexia and tenesmus. A large caudal abdominal mass was palpated on physical examination. On ultrasound, the mass encircled and obstructed the left ureter, resulting in hydroureter and hydronephrosis. The animal was euthanized, and necropsy revealed a large retroperitoneal pyogranuloma with acid-fast organisms identified in both the mass and the perineal skin. The acid-fast organisms within the retroperitoneal mass were identified as Mycobacterium intracellulare by PCR. This case represents an unusual presentation of M. intracellulare in a novel species.}, number={2}, journal={JOURNAL OF ZOO AND WILDLIFE MEDICINE}, author={Adamovicz, Laura and Kennedy-Stoskopf, Suzanne and Talley, Ashley and Cullen, John M. and Cohen, Eli B. and Bizikova, Petra and Grunkemeyer, Vanessa}, year={2017}, month={Jun}, pages={544–548} }
 @article{bizikova_olivry_2016, title={A randomized, double-blinded crossover trial testing the benefit of two hydrolysed poultry-based commercial diets for dogs with spontaneous pruritic chicken allergy}, volume={27}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84987925072&partnerID=MN8TOARS}, DOI={10.1111/vde.12302}, abstractNote={BackgroundHydrolysed protein diets are used to diagnose and treat dogs with cutaneous adverse food reactions (CAFR). Little is known about what proportion of dogs hypersensitive to the native protein would react to its hydrolysed form.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={Bizikova, Petra and Olivry, Thierry}, year={2016}, month={Aug}, pages={289–E70} }
 @article{tham_jacob_bizikova_2016, title={Molecular confirmation of shampoo as the putative source of Pseudomonas aeruginosa-induced postgrooming furunculosis in a dog}, volume={27}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12332}, abstractNote={BackgroundAn acute onset furunculosis due to Pseudomonas aeruginosa following grooming is a well recognized entity. Although contaminated shampoos have been suspected to be the source of the infection, a molecular confirmation of this association has been missing.}, number={4}, journal={VETERINARY DERMATOLOGY}, author={Tham, Heng L. and Jacob, Megan E. and Bizikova, Petra}, year={2016}, month={Aug}, pages={320–E80} }
 @article{tham_olivry_linder_bizikova_2016, title={Mucous membrane pemphigoid in dogs: A retrospective study of 16 new cases}, volume={27}, number={5}, journal={Veterinary Dermatology}, author={Tham, H. L. and Olivry, T. and Linder, K. E. and Bizikova, P.}, year={2016}, pages={376-} }
 @article{bizikova_linder_wofford_mamo_dunston_olivry_2015, title={Canine epidermolysis bullosa acquisita: A retrospective study of 20 cases}, volume={26}, number={6}, journal={Veterinary Dermatology}, author={Bizikova, P. and Linder, K. E. and Wofford, J. A. and Mamo, L. B. and Dunston, S. M. and Olivry, T.}, year={2015}, pages={441-} }
 @article{bizikova_moriello_linder_sauber_2015, title={Dinotefuran/pyriproxyfen/permethrin pemphigus-like drug reaction in three dogs}, volume={26}, number={3}, journal={Veterinary Dermatology}, author={Bizikova, P. and Moriello, K. A. and Linder, K. E. and Sauber, L.}, year={2015}, pages={206-} }
 @article{pucheu-haston_eisenschenk_bizikova_marsella_nuttall_santoro_2015, title={Introduction to the review articles by ICADA on the pathogenesis of atopic dermatitis in dogs}, volume={26}, ISSN={["1365-3164"]}, DOI={10.1111/vde.12207}, abstractNote={Introduction to the review articles by ICADA on the pathogenesis of atopic dermatitis in dogs' Veterinary Dermatology, vol 26, no. 2, pp. 77-78. General rights Copyright for the publications made accessible via the Edinburgh Research Explorer is retained by the author(s) and / or other copyright owners and it is a condition of accessing these publications that users recognise and abide by the legal requirements associated with these rights. Take down policy The University of Edinburgh has made every reasonable effort to ensure that Edinburgh Research Explorer content complies with UK legislation. If you believe that the public display of this file breaches copyright please contact openaccess@ed.ac.uk providing details, and we will remove access to the work immediately and investigate your claim.}, number={2}, journal={VETERINARY DERMATOLOGY}, author={Pucheu-Haston, Cherie M. and Eisenschenk, Melissa N. C. and Bizikova, Petra and Marsella, Rosanna and Nuttall, Tim and Santoro, Domenico}, year={2015}, month={Apr}, pages={77–78} }
 @article{bizikova_olivry_2015, title={Oral glucocorticoid pulse therapy for induction of treatment of canine pemphigus foliaceus - a comparative study}, volume={26}, number={5}, journal={Veterinary Dermatology}, author={Bizikova, P. and Olivry, T.}, year={2015}, pages={354-} }
 @article{tham_linder_tucker_maggi_bizikova_2015, title={Protozoal nodular dermatitis and panniculitis in a Rottweiler puppy caused by Caryospora bigenetica}, volume={27}, ISSN={0959-4493}, url={http://dx.doi.org/10.1111/vde.12271}, DOI={10.1111/vde.12271}, abstractNote={BackgroundCaryospora bigenetica is an intracellular protozoan parasite in snakes and raptors (primary hosts) and rodents (secondary host). Experimental infection has been documented in mice, pigs and goats; natural infection in dogs is rare.}, number={1}, journal={Veterinary Dermatology}, publisher={Wiley}, author={Tham, Heng L. and Linder, Keith E. and Tucker, Alison and Maggi, Ricardo and Bizikova, Petra}, year={2015}, month={Nov}, pages={44–e12} }
 @misc{bizikova_santoro_marsella_nuttall_eisenschenk_pucheu-haston_2015, title={Review: Clinical and histological manifestations of canine atopic dermatitis}, volume={26}, number={2}, journal={Veterinary Dermatology}, author={Bizikova, P. and Santoro, D. and Marsella, R. and Nuttall, T. and Eisenschenk, M. N. C. and Pucheu-Haston, C. M.}, year={2015} }
 @misc{pucheu-haston_santoro_bizikova_eisenschenk_marsella_nuttall_2015, title={Review: Innate immunity, lipid metabolism and nutrition in canine atopic dermatitis}, volume={26}, number={2}, journal={Veterinary Dermatology}, author={Pucheu-Haston, C. M. and Santoro, D. and Bizikova, P. and Eisenschenk, M. N. C. and Marsella, R. and Nuttall, T.}, year={2015} }
 @misc{pucheu-haston_bizikova_marsella_santoro_nuttall_eisenschenk_2015, title={Review: Lymphocytes, cytokines, chemokines and the T-helper 1-T-helper 2 balance in canine atopic dermatitis}, volume={26}, number={2}, journal={Veterinary Dermatology}, author={Pucheu-Haston, C. M. and Bizikova, P. and Marsella, R. and Santoro, D. and Nuttall, T. and Eisenschenk, M. N. C.}, year={2015} }
 @misc{santoro_marsella_pucheu-haston_eisenschenk_nuttall_bizikova_2015, title={Review: Pathogenesis of canine atopic dermatitis: skin barrier and host-micro-organism interaction}, volume={26}, number={2}, journal={Veterinary Dermatology}, author={Santoro, D. and Marsella, R. and Pucheu-Haston, C. M. and Eisenschenk, M. N. C. and Nuttall, T. and Bizikova, P.}, year={2015} }
 @misc{bizikova_pucheu-haston_eisenschenk_marsella_nuttall_santoro_2015, title={Review: Role of genetics and the environment in the pathogenesis of canine atopic dermatitis}, volume={26}, number={2}, journal={Veterinary Dermatology}, author={Bizikova, P. and Pucheu-Haston, C. M. and Eisenschenk, M. N. C. and Marsella, R. and Nuttall, T. and Santoro, D.}, year={2015} }
 @misc{pucheu-haston_bizikova_eisenschenk_santoro_nuttall_marsella_2015, title={Review: The role of antibodies, autoantigens and food allergens in canine atopic dermatitis}, volume={26}, number={2}, journal={Veterinary Dermatology}, author={Pucheu-Haston, C. M. and Bizikova, P. and Eisenschenk, M. N. C. and Santoro, D. and Nuttall, T. and Marsella, R.}, year={2015} }
 @article{bizikova_linder_olivry_2014, title={Fipronil-amitraz-S-methoprene-triggered pemphigus foliaceus in 21 dogs: clinical, histological and immunological characteristics}, volume={25}, number={2}, journal={Veterinary Dermatology}, author={Bizikova, P. and Linder, K. E. and Olivry, T.}, year={2014}, pages={103-} }
 @article{bizikova_2014, title={Localized demodicosis due to Demodex cati on the muzzle of two cats treated with inhalant glucocorticoids}, volume={25}, number={3}, journal={Veterinary Dermatology}, author={Bizikova, P.}, year={2014}, pages={222-} }
 @article{bizikova_olivry_mamo_dunston_2014, title={Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus}, volume={25}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84911375280&partnerID=MN8TOARS}, DOI={10.1111/vde.12143}, abstractNote={BackgroundPemphigus foliaceus (PF) is the most common IgG‐mediated autoimmune skin disease in dogs. Studies of human PF have revealed the presence of other antigen‐specific autoantibody isotypes, thereby uncovering new avenues of investigation of the disease pathomechanism.}, number={5}, journal={VETERINARY DERMATOLOGY}, author={Bizikova, Petra and Olivry, Thierry and Mamo, Lisa B. and Dunston, Stanley M.}, year={2014}, month={Oct}, pages={471–E75} }
 @article{olivry_bizikova_paps_dunston_lerner_yosipovitch_2013, title={Cowhage can induce itch in the atopic dog}, volume={22}, ISSN={["1600-0625"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84878344758&partnerID=MN8TOARS}, DOI={10.1111/exd.12158}, abstractNote={Abstract}, number={6}, journal={EXPERIMENTAL DERMATOLOGY}, author={Olivry, Thierry and Bizikova, Petra and Paps, Judy S. and Dunston, Stan and Lerner, Ethan A. and Yosipovitch, Gil}, year={2013}, month={Jun}, pages={435–437} }
 @article{bizikova_dean_hashimoto_olivry_2012, title={Cloning and establishment of canine desmocollin-1 as a major autoantigen in canine pemphigus foliaceus}, volume={149}, ISSN={["0165-2427"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-84866356195&partnerID=MN8TOARS}, DOI={10.1016/j.vetimm.2012.06.025}, abstractNote={Pemphigus foliaceus (PF) is the most common antibody-mediated autoimmune skin disease of dogs. Desmoglein-1 (DSG1), the major human PF antigen, represents only a minor autoantigen in canine PF (cPF). A recent immunomapping study proposed desmocollin-1 (DSC1) as a relevant candidate autoantigen for cPF. To investigate this hypothesis, 85 cPF sera were screened for the presence of anti-DSC1 IgG using indirect immunofluorescence (IIF) on live canine DSC1-transfected 293T cells. Seventy-five sera contained detectable antikeratinocyte IgG on IIF using footpad substrate (IIFpos cPF), while 10 did not (IIFneg cPF). Sera from 35 healthy dogs, eight from exfoliative superficial pyoderma (ESP)-affected dogs and 21 dogs with non-PF autoimmune blistering skin diseases served as controls. All sera were tested concurrently by IIF on canine DSG1-transfected as well as nontransfected cells. None of the healthy dog or ESP sera labelled any of the transfected or nontransfected cells. Fifty-seven of 75 IIFpos cPF (86%) and 7/10 of IIFneg cPF sera (70%) contained detectable anti-DSC1 IgG. None of these sera recognized nontransfected cells. Five cPF sera (6%) recognized DSG1 in addition to DSC1. Finally, 5/21 (24%) sera from dogs with non-PF autoimmune blistering diseases contained low anti-DSC1 IgG titers. In 7/10 dogs (70%), from whom serial serum samples were collected during treatment, anti-DSC1 IgG titers decreased in parallel with the reduction in disease clinical severity. Altogether, these findings suggest that DSC1 is a major autoantigen in cPF.}, number={3-4}, journal={VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY}, author={Bizikova, Petra and Dean, Gregg A. and Hashimoto, Takashi and Olivry, Thierry}, year={2012}, month={Oct}, pages={197–207} }
 @article{olivry_linder_wang_bizikova_bernstein_dunston_paps_casal_2012, title={Deficient plakophilin-1 expression due to a mutation in PKP1 causes ectodermal dysplasia-skin fragility syndrome in Chesapeake Bay Retriever dogs}, volume={7}, number={2}, journal={PLoS One}, author={Olivry, T. and Linder, K. E. and Wang, P. and Bizikova, P. and Bernstein, J. A. and Dunston, S. M. and Paps, J. S. and Casal, M. L.}, year={2012} }
 @article{olivry_linder_paps_bizikova_dunston_donne_mondoulet_2012, title={Validation of a novel epicutaneous delivery system for patch testing of house dust mite-hypersensitive dogs}, volume={23}, number={6}, journal={Veterinary Dermatology}, author={Olivry, T. and Linder, K. E. and Paps, J. S. and Bizikova, P. and Dunston, S. and Donne, N. and Mondoulet, L.}, year={2012} }
 @article{bizikova_linder_olivry_2011, title={Immunomapping of desmosomal and nondesmosomal adhesion molecules in healthy canine footpad, haired skin and buccal mucosal epithelia: comparison with canine pemphigus foliaceus serum immunoglobulin G staining patterns}, volume={22}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-79952335927&partnerID=MN8TOARS}, DOI={10.1111/j.1365-3164.2010.00924.x}, abstractNote={Abstract}, number={2}, journal={VETERINARY DERMATOLOGY}, author={Bizikova, Petra and Linder, Keith E. and Olivry, Thierry}, year={2011}, month={Apr}, pages={132–142} }
 @article{oberkirchner_linder_dunston_bizikova_olivry_2011, title={Metaflumizone-amitraz (Promeris)-associated pustular acantholytic dermatitis in 22 dogs: evidence suggests contact drug-triggered pemphigus foliaceus}, volume={22}, ISSN={["0959-4493"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-80052525616&partnerID=MN8TOARS}, DOI={10.1111/j.1365-3164.2011.00974.x}, abstractNote={Abstract}, number={5}, journal={VETERINARY DERMATOLOGY}, author={Oberkirchner, Ursula and Linder, Keith E. and Dunston, Stan and Bizikova, Petra and Olivry, Thierry}, year={2011}, month={Oct}, pages={436–448} }
 @article{olivry_bizikova_2010, title={A systematic review of the evidence of reduced allergenicity and clinical benefit of food hydrolysates in dogs with cutaneous adverse food reactions}, volume={21}, number={1}, journal={Veterinary Dermatology}, author={Olivry, T. and Bizikova, P.}, year={2010}, pages={31–40} }
 @article{olivry_bizikova_dunston_bond_halliwell_loeffler_pucheu-haston_chen_marinkovich_2010, title={Clinical and immunological heterogeneity of canine subepidermal blistering dermatoses with anti-laminin-332 (laminin-5) auto-antibodies}, volume={21}, number={4}, journal={Veterinary Dermatology}, author={Olivry, T. and Bizikova, P. and Dunston, S. M. and Bond, R. and Halliwell, R. and Loeffler, A. and Pucheu-Haston, C. M. and Chen, M. and Marinkovich, M. P.}, year={2010}, pages={345–357} }
 @article{bizikova_linder_suter_van wettere_olivry_2009, title={Canine cutaneous epitheliotropic T-cell lymphoma with vesiculobullous lesions resembling human bullous mycosis fungoides}, volume={20}, ISSN={0959-4493 1365-3164}, url={http://dx.doi.org/10.1111/j.1365-3164.2009.00760.x}, DOI={10.1111/j.1365-3164.2009.00760.x}, abstractNote={Abstract}, number={4}, journal={Veterinary Dermatology}, publisher={Wiley}, author={Bizikova, Petra and Linder, Keith E. and Suter, Steven E. and Van Wettere, Arnaud J. and Olivry, Thierry}, year={2009}, month={Aug}, pages={281–288} }
 @article{bizikova_papich_olivry_2008, title={Hydroxyzine and cetirizine pharmacokinetics and pharmacodynamics after oral and intravenous administration of hydroxyzine to healthy dogs}, volume={19}, ISSN={["1365-3164"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-57449092680&partnerID=MN8TOARS}, DOI={10.1111/j.1365-3164.2008.00697.x}, abstractNote={Abstract}, number={6}, journal={VETERINARY DERMATOLOGY}, author={Bizikova, Petra and Papich, Mark G. and Olivry, Thierry}, year={2008}, month={Dec}, pages={348–357} }