Paul E. Orndorff

Works (49)

Updated: April 4th, 2024 23:33

2019 journal article

The Ion Delivery Manner Influences the Antimicrobial Efficacy of Silver Oligodynamic Iontophoresis

JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 39(4), 622–631.

By: G. Tan*, P. Orndorff n & R. Shirwaiker n 

author keywords: Oligodynamic iontophoresis; Silver ion; Antimicrobial activities; Electrical activation
TL;DR: The antimicrobial activities of the silver-based iontophoresis prototype was more sensitive to current duration than current intensity, and the marginal antimicrobial efficacy of the device decreased as the current intensity increased. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 5, 2019

2018 journal article

In silico predicted glucose-1-phosphate Uridylyltransferase (GalU) inhibitors block a key pathway required for Listeria virulence

Molecular Informatics, 37(6-7).

By: M. Kuenemann, P. Spears, P. Orndorff & D. Fourches

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver-titanium implant system prototype

BIOMETALS, 30(1), 113–125.

By: Z. Tan n, E. Havell n, P. Orndorff n & R. Shirwaiker n 

Contributors: Z. Tan n, E. Havell n, P. Orndorff n & R. Shirwaiker n 

author keywords: Low intensity direct current; Silver-titanium implant; Orthopaedic application; Antimicrobial efficacy; Cytotoxicity
MeSH headings : Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Cell Proliferation / drug effects; Ions / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Titanium / chemistry; Titanium / pharmacology
TL;DR: The in vitro antibacterial efficacy and cytotoxicity of a low intensity direct current (LIDC)-activated silver–titanium implant system prototype designed for localized generation and delivery of silver ions at the implantation site showed high antimicrobial efficacy against MRSA, but was also toxic to human cells immediately surrounding the electrodes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Effects of Electrically Activated Silver-Titanium Implant System Design Parameters on Time-Kill Curves Against Staphylococcus aureus

JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 36(3), 325–333.

By: Z. Tan n, G. Xu n, P. Orndorff n & R. Shirwaiker n 

Contributors: Z. Tan n, G. Xu n, P. Orndorff n & R. Shirwaiker n 

author keywords: Antimicrobial efficacy; Orthopaedic implants; Ionic silver; Post-operative infections; Design parameters
TL;DR: The in vitro antimicrobial efficacy of a silver-based prophylactic system for orthopaedic implant applications is characterized and provides a reference of design parameters for future product engineering. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Evaluation of silver-titanium implants activated by low intensity direct current for orthopedic infection control: An in vitro and in vivo study

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 104(5), 1023–1031.

By: D. Cavanaugh*, Z. Tan n, J. Norris*, A. Hardee n, P. Weinhold n, L. Dahners*, P. Orndorff n, R. Shirwaiker n 

Contributors: D. Cavanaugh*, Z. Tan n, J. Norris*, A. Hardee n, P. Weinhold n, L. Dahners*, P. Orndorff n, R. Shirwaiker n 

author keywords: prosthetic infection; oligodynamic silver; antimicrobial implant; electrical activation
MeSH headings : Animals; Female; Femur / microbiology; Femur / surgery; Implants, Experimental; Rats; Rats, Sprague-Dawley; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / prevention & control; Staphylococcus aureus / growth & development; Titanium / chemistry; Titanium / pharmacology
TL;DR: In vivo, none of the four groups were able to prevent wound infection, but the experimental group resulted in reduced colonization, and the antimicrobial potential of LIDC-activated Ag-Ti implants is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Listeria monocytogenes wall teichoic acid decoration in virulence and cell-to-cell spread

MOLECULAR MICROBIOLOGY, 101(5), 714–730.

By: P. Spears n, E. Havell n, T. Hamrick*, J. Goforth*, A. Levine*, S. Abraham*, C. Heiss *, P. Azadi *, P. Orndorff n

MeSH headings : Animals; Bacteriophages / metabolism; Cell Membrane / metabolism; Cell Wall / metabolism; Female; Listeria monocytogenes / metabolism; Listeria monocytogenes / pathogenicity; Listeriosis / microbiology; Liver / microbiology; Mice; Mutation; Peptidoglycan / metabolism; Spleen / microbiology; Teichoic Acids / metabolism; Virulence
TL;DR: Identification and interruption of WTA decoration pathways may provide a general strategy to discover non‐antibiotic therapeutics for gram positive infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 review

Use of bacteriophage to target bacterial surface structures required for virulence: a systematic search for antibiotic alternatives

[Review of ]. CURRENT GENETICS, 62(4), 753–757.

By: P. Orndorff n

author keywords: Bacteriophage; Phage; Receptor; Attenuation; Therapy; Antibiotic; Alternative; Antivirulence factor
MeSH headings : Animals; Anti-Bacterial Agents / biosynthesis; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / pathogenicity; Bacteria / virology; Bacterial Infections / microbiology; Bacterial Physiological Phenomena; Bacteriophages / physiology; Cell Membrane / metabolism; Drug Discovery; Humans; Receptors, Virus / metabolism; Virulence
TL;DR: Examples of how mutations that confer phage resistance produce attenuation are covered, and how this coincidental relationship can be exploited in the search for the next generation of therapeutic agents for bacterial diseases are covered. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

The Haemophilus ducreyi trimeric autotransporter adhesin DsrA protects against an experimental infection in the swine model of chancroid

VACCINE, 32(30), 3752–3758.

By: W. Fusco *, N. Choudhary *, P. Routh n, M. Ventevogel*, V. Smith *, G. Koch*, G. Almond n , P. Orndorff n, G. Sempowski *, I. Leduc*

author keywords: Haemophilus ducreyi; Trimeric autotransporter adhesin; DsrA; Active protection
MeSH headings : Adhesins, Bacterial / immunology; Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Bacterial / blood; Bacterial Vaccines / immunology; Chancroid / prevention & control; Disease Models, Animal; Fibrinogen / metabolism; Haemophilus ducreyi; Immune Sera / immunology; Immunity, Humoral; Immunoglobulin G / blood; Recombinant Proteins / immunology; Sus scrofa
TL;DR: Overall, immunization with the passenger domain of the trimeric autotransporter adhesin DsrA accelerated clearance of H. ducreyi in experimental lesions, possibly by interfering with fibrinogen binding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 24(3), 755–760.

By: M. Samberg n, Z. Tan*, N. Monteiro-Riviere n , P. Orndorff n & R. Shirwaiker* 

Contributors: M. Samberg n, Z. Tan*, N. Monteiro-Riviere n , P. Orndorff n & R. Shirwaiker* 

MeSH headings : Anti-Bacterial Agents; Biocompatible Materials; Equipment and Supplies; Escherichia coli / drug effects; Microbial Sensitivity Tests; Silver; Staphylococcus aureus / drug effects; Surface Properties
TL;DR: The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2013 conference paper

Determining optimal current intensity and duration for electrically activated silver-based prophylactic hip implant prototype design

ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 B.

By: Z. Tan n, R. Shirwaiker n  & P. Orndoff n

Contributors: Z. Tan n, R. Shirwaiker n  & P. Orndoff n

TL;DR: Preliminary in vitro and in vivo results have demonstrated the potency of silver-based OI as an effective local antibacterial therapy in osteomyelitis treatment with advantages over various antibiotics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2013 journal article

Extrauterine Listeriosis in the gravid mouse influences embryonic growth and development

PLoS One, 8(8).

By: M. Suyemoto, T. Hamrick, P. Spears, J. Horton, I. Washington, E. Havell, L. Borst , P. Orndorff

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Antibacterial efficacy of silver nanoparticles of different sizes, surface conditions and synthesis methods

NANOTOXICOLOGY, 5(2), 244–253.

By: M. Samberg n, P. Orndorff n & N. Monteiro-Riviere n 

Contributors: M. Samberg n, P. Orndorff n & N. Monteiro-Riviere n 

author keywords: Silver; nanoparticles; nanotechnology; nanotoxicity; microbiology
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Escherichia coli / drug effects; Humans; Materials Testing; Metal Nanoparticles / chemistry; Metal Nanoparticles / ultrastructure; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Particle Size; Silver / chemistry; Silver / pharmacology; Staphylococcus aureus / drug effects; Surface Properties
TL;DR: Silver nanoparticles are used as a natural biocide to prevent undesired bacterial growth in clothing and cosmetics to assess the antibacterial efficacy of Ag-nps of different sizes, surface conditions, and synthesis methods against Escherichia coli, Ag-resistant E. coli, methicillin-resistant S. aureus, and Salmonella sp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

In Vitro Properties of a Listeria monocytogenes Bacteriophage-Resistant Mutant Predict Its Efficacy as a Live Oral Vaccine Strain

INFECTION AND IMMUNITY, 79(12), 5001–5009.

By: P. Spears n, M. Suyemoto n, T. Hamrick*, R. Wolf n, E. Havell n & P. Orndorff n

MeSH headings : Administration, Oral; Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / immunology; Bacterial Vaccines / standards; Bacteriophages / physiology; Cells, Cultured; Enterocytes / microbiology; Female; Listeria monocytogenes / genetics; Listeria monocytogenes / virology; Listeriosis / microbiology; Listeriosis / prevention & control; Mice; Mice, Inbred BALB C; Mutagenesis, Insertional; Mutation; Time Factors; Vaccines, Attenuated / administration & dosage; Vaccines, Attenuated / standards
TL;DR: The results indicate that oral administration of a profoundly attenuated listeria monocytogenes glcV mutant can safely elicit solid protective immunity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Incorporation of secretory immunoglobulin A into biofilms can decrease their resistance to ciprofloxacin

MICROBIOLOGY AND IMMUNOLOGY, 55(3), 174–183.

By: Y. Lee, K. Su *, A. Wyse, A. Barbas, D. Palestrandt, K. Shieh, M. Everett, A. Devalapalli ...

author keywords: antibiotic; ciprofloxacin; Escherichia coli; host-supported biofilms
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Ciprofloxacin / pharmacology; Culture Media / chemistry; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / immunology; Escherichia coli / drug effects; Escherichia coli / physiology; Humans; Immunoglobulin A, Secretory / pharmacology; Mice; Milk / immunology
TL;DR: It is suggested that incorporation of host‐derived molecules into the extracellular matrix of symbiotic biofilms might profoundly alter the properties of thoseBiofilms, including the resistance of those bioFilms to antibiotics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Passive Immunization with a Polyclonal Antiserum to the Hemoglobin Receptor of Haemophilus ducreyi Confers Protection against a Homologous Challenge in the Experimental Swine Model of Chancroid

INFECTION AND IMMUNITY, 79(8), 3168–3177.

By: I. Leduc*, W. Fusco *, N. Choudhary *, P. Routh n, D. Cholon *, M. Hobbs*, G. Almond n , P. Orndorff n, C. Elkins *

MeSH headings : Animals; Antibodies, Bacterial / administration & dosage; Antibodies, Bacterial / immunology; Bacterial Proteins / immunology; Carrier Proteins / immunology; Chancroid / immunology; Chancroid / pathology; Chancroid / prevention & control; Disease Models, Animal; Ear / pathology; Haemophilus ducreyi / immunology; Haemophilus ducreyi / pathogenicity; Histocytochemistry; Immune Sera / administration & dosage; Immune Sera / immunology; Immunization, Passive / methods; Microbial Viability; Microscopy; Receptors, Cell Surface / immunology; Swine; Swine Diseases / immunology; Swine Diseases / prevention & control
TL;DR: Data suggest that the humoral immune response to the HgbA vaccine is protective against an H. ducreyi infection, possibly by preventing acquisition of the essential nutrient heme. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Adaptation in a Mouse Colony Monoassociated with Escherichia coli K-12 for More than 1,000 Days

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 76(14), 4655–4663.

By: S. Lee *, A. Wyse *, A. Lesher *, M. Everett*, L. Lou*, Z. Holzknecht*, J. Whitesides n, P. Spears n ...

MeSH headings : Animals; Escherichia coli K12 / genetics; Escherichia coli K12 / growth & development; Gastrointestinal Tract / microbiology; Longitudinal Studies; Mice; Restriction Mapping
TL;DR: The results suggest that monoassociated mice might be used as a tool for characterizing niches occupied by the intestinal flora and potentially as a method of targeting the evolution of bacteria for applications in biotechnology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Factors Associated with the Acquisition and Severity of Gestational Listeriosis

PLOS ONE, 5(9).

By: M. Suyemoto n, P. Spears n, T. Hamrick*, J. Barnes n, E. Havell n & P. Orndorff n

MeSH headings : Animals; Disease Models, Animal; Female; Humans; Listeria / physiology; Listeriosis / embryology; Listeriosis / microbiology; Listeriosis / pathology; Liver / microbiology; Liver / pathology; Mice; Pregnancy; Pregnancy Complications, Infectious / microbiology; Pregnancy Complications, Infectious / pathology; Severity of Illness Index; Spleen / microbiology; Spleen / pathology
TL;DR: It was determined in mice that increased susceptibility to lethal infection following oral inoculation begins surprisingly early in pregnancy and extends through embryonic development, and the window of listeriosis susceptibility afforded by pregnancy may be open longer than previously appreciated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Identification and Characterization of Two Bordetella avium Gene Products Required for Hemagglutination

INFECTION AND IMMUNITY, 78(6), 2370–2376.

By: L. Temple*, D. Miyamoto*, M. Mehta*, C. Capitini *, S. Von Stetina*, H. Barnes n, V. Christensen n, J. Horton n, P. Spears n, P. Orndorff n

MeSH headings : Animals; Antibodies, Bacterial / immunology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Bordetella avium / pathogenicity; Cell Adhesion; Cells, Cultured; DNA Transposable Elements; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Epithelial Cells / microbiology; Erythrocytes / microbiology; Gene Order; Guinea Pigs; Hemagglutination; Hemagglutinins / genetics; Hemagglutinins / metabolism; Molecular Sequence Data; Mutagenesis, Insertional; Poultry Diseases / microbiology; Sequence Analysis, DNA; Sequence Deletion; Trachea / microbiology; Turkeys
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Immunization with the Haemophilus ducreyi Hemoglobin Receptor HgbA with Adjuvant Monophosphoryl Lipid A Protects Swine from a Homologous but Not a Heterologous Challenge

INFECTION AND IMMUNITY, 78(9), 3763–3772.

By: W. Fusco *, G. Afonina*, I. Nepluev*, D. Cholon *, N. Choudhary *, P. Routh n, G. Almond n , P. Orndorff n ...

MeSH headings : Adjuvants, Immunologic / administration & dosage; Animals; Antibodies, Bacterial / blood; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Vaccines / immunology; Carrier Proteins / genetics; Carrier Proteins / immunology; Chancroid / prevention & control; Enzyme-Linked Immunosorbent Assay; Haemophilus ducreyi / immunology; Immune Sera / immunology; Immunization; Lipid A / administration & dosage; Lipid A / analogs & derivatives; Swine
TL;DR: This study investigated whether nHgbAI dispensed with monophosphoryl lipid A (MPL), an adjuvant approved for use in humans, offered protection against a challenge with H. ducreyi and found that a bivalent HgbA vaccine may be needed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Altering and Assessing Persistence of Genetically Modified E. coli MG1655 in the Large Bowel

EXPERIMENTAL BIOLOGY AND MEDICINE, 234(10), 1174–1185.

By: A. Barbas  n, A. Lesher  n, A. Thomas n, A. Wyse  n, A. Devalapalli n, Y. Lee n, H. Tan n, P. Orndorff n, R. Bollinger n, W. Parker  n

author keywords: probiotics; pilus; immunoglobulin A
MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Bacterial / metabolism; Animals; Bacterial Adhesion; Cecum / immunology; Cecum / metabolism; Escherichia coli K12 / genetics; Escherichia coli K12 / metabolism; Feces / microbiology; Female; Fimbriae, Bacterial / metabolism; Immunoglobulin A, Secretory / immunology; Immunoglobulin A, Secretory / metabolism; Intestinal Mucosa / immunology; Intestinal Mucosa / metabolism; Intestine, Large / immunology; Intestine, Large / metabolism; Mice; Mice, Inbred Strains; Probiotics / metabolism; Time Factors
TL;DR: Modifying expression of probiotic colonization factors may provide substantial benefit to patients with digestive tract diseases by virtue of increased persistence of the probiotic and, in the case of sIgA, an anti-inflammatory effect. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Quantitative Glycomics from Fluidic Glycan Microarrays

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(38), 13646–13650.

By: X. Zhu  n, B. Holtz n, Y. Wang  n, L. Wang  n, P. Orndorff n & A. Guo n

MeSH headings : Adhesins, Escherichia coli / chemistry; Adhesins, Escherichia coli / metabolism; Bacterial Adhesion; Cell Membrane / chemistry; Cell Membrane / metabolism; Cell Membrane / physiology; Escherichia coli / chemistry; Escherichia coli / physiology; Fimbriae Proteins / chemistry; Fimbriae Proteins / metabolism; Glycomics / methods; Mannose / chemistry; Mannose / metabolism; Microarray Analysis / methods; Microfluidic Analytical Techniques; Polysaccharides / analysis; Polysaccharides / metabolism
TL;DR: The results reveal a new E. coli adhesion mechanism: the switching in the FimH adhesion protein avidity from monovalent to multivalent as the density of mobile mannosyl groups increases; such avidity switching enhances binding affinity and triggers multiple fimbriae anchoring. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

A Listeria monocytogenes mutant defective in bacteriophage attachment is attenuated in orally inoculated mice and impaired in enterocyte intracellular growth

INFECTION AND IMMUNITY, 76(9), 4046–4054.

By: P. Spears n, M. Suyemoto n, A. Palermo n, J. Horton n, T. Hamrick*, E. Havell n, P. Orndorff n

MeSH headings : Animals; Bacterial Adhesion; Bacteriophages / physiology; DNA Transposable Elements; DNA, Bacterial / chemistry; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Genetic Complementation Test; Glycosyltransferases / genetics; Listeria monocytogenes / pathogenicity; Listeria monocytogenes / virology; Listeriosis / microbiology; Liver / microbiology; Mice; Mice, Inbred A; Molecular Sequence Data; Mutagenesis, Insertional; Receptors, Virus / genetics; Sequence Analysis, DNA; Spleen / microbiology; Survival Analysis; Viral Plaque Assay; Virulence; Virulence Factors / genetics; Virus Attachment
TL;DR: Interestingly, the glcV lesion, while preventing phage attachment, did not alter the mutant's ability to bind to cultured mouse enterocyte monolayers, rather, the mutation appeared to alter a subsequent step in intracellular replication measured by a reduction in plaque-forming efficiency and plaque size. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Comparison of the genome sequence of the poultry pathogen Bordetella avium with those of B-bronchiseptica, B-pertussis, and B-parapertussis reveals extensive diversity in surface structures associated with host interaction

Journal of Bacteriology, 188(16), 6002–6015.

By: M. Sebaihia & P. Orndorff

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid

INFECTION AND IMMUNITY, 74(5), 2651–2658.

By: R. Fulcher*, L. Cole*, D. Janowicz, K. Toffer*, K. Fortney, B. Katz, P. Orndorff n, S. Spinola *, T. Kawula *

MeSH headings : Adhesins, Bacterial / physiology; Adult; Animals; Bacterial Adhesion; Bacterial Outer Membrane Proteins / physiology; Blood Bactericidal Activity; Chancroid / etiology; Collagen / metabolism; Disease Models, Animal; Female; Fibroblasts / microbiology; Haemophilus ducreyi / immunology; Haemophilus ducreyi / pathogenicity; Humans; Keratinocytes / microbiology; Male; Middle Aged; Swine; Virulence
TL;DR: It is demonstrated that the collagen binding protein NcaA is required for H. ducreyi infection and binding to type I collagen is sufficient to confer collagen attachment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 review

Host and bacterial factors in listeriosis pathogenesis

[Review of ]. VETERINARY MICROBIOLOGY, 114(1-2), 1–15.

By: P. Orndorff n, T. Hamrick*, I. Smoak n & E. Havell n

author keywords: listeria; pathogenesis; pregnancy; predisposition; veterinary
MeSH headings : Animals; Cytosol / microbiology; Disease Susceptibility / microbiology; Environment; Female; Food Microbiology; Humans; Immunity, Cellular / immunology; Listeria / growth & development; Listeria / pathogenicity; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / transmission; Mice; Pregnancy; Pregnancy Complications, Infectious / immunology; Pregnancy Complications, Infectious / microbiology; Vacuoles / microbiology
TL;DR: There are many features of the pathogenesis of listeriosis that have remained mysterious despite the extensive use of the microorganism in the study of cell-mediated immunity and intracellular growth, and Informational advances such as the sequence of the mouse and listerial genomes, and technical advancessuch as the discovery of listersia-susceptible mouse strains, may renew interest in the project. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid

INFECTION AND IMMUNITY, 74(4), 2224–2232.

By: G. Afonina, I. Leduc, I. Nepluev, C. Jeter, P. Routh n, G. Almond n , P. Orndorff n, M. Hobbs*, C. Elkins *

MeSH headings : Animals; Antibodies, Bacterial / biosynthesis; Antibodies, Bacterial / blood; Antibodies, Bacterial / metabolism; Bacterial Proteins / administration & dosage; Bacterial Proteins / immunology; Binding Sites, Antibody; Carrier Proteins / administration & dosage; Carrier Proteins / immunology; Chancroid / immunology; Chancroid / microbiology; Chancroid / pathology; Chancroid / prevention & control; Disease Models, Animal; Haemophilus Vaccines / administration & dosage; Haemophilus Vaccines / immunology; Haemophilus ducreyi / immunology; Hemoglobins / metabolism; Immunoglobulin G / metabolism; Immunoglobulin G / physiology; Protein Binding / immunology; Swine
TL;DR: Data suggest continuing the development of an HgbA subunit vaccine to prevent chancroid, and suggests such a vaccine strategy might be applied to other bacterial pathogens with strict heme/iron requirements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Secretory IgA and mucin-mediated biofilm formation by environmental strains of Escherichia coli: role of type 1 pili

MOLECULAR IMMUNOLOGY, 43(4), 378–387.

By: R. Bollinger*, M. Everett*, S. Wahl*, Y. Lee*, P. Orndorff n & W. Parker *

author keywords: secretory IgA; mucin; type 1 pilus; epithelial cells; biofilm; E. coli
MeSH headings : Adenocarcinoma / pathology; Animals; Bacterial Adhesion / physiology; Biofilms; Cell Line, Tumor / microbiology; Colonic Neoplasms / pathology; Escherichia coli / isolation & purification; Escherichia coli K12 / physiology; Feces / microbiology; Female; Fimbriae, Bacterial / physiology; Humans; Immunoglobulin A, Secretory / isolation & purification; Immunoglobulin A, Secretory / physiology; Mannose-Binding Lectins / physiology; Membranes, Artificial; Mice / microbiology; Milk, Human / immunology; Mucins / physiology; Polystyrenes; Species Specificity
TL;DR: These studies provide the first procedures for the growth of bacterial biofilms on live epithelial cells in vitro, an important development that may facilitate future studies on the effects of bacterial Biofilm formation by commensal bacteria within the mammalian gut. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Immunoglobulin-mediated agglutination of and biofilm formation by Escherichia coli K-12 require the type 1 pilus fiber

INFECTION AND IMMUNITY, 72(4), 1929–1938.

By: P. Orndorff n, A. Devapali, S. Palestrant, A. Wyse, M. Everett, R. Bollinger*, W. Parker

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Bacterial / metabolism; Agglutination; Bacterial Adhesion; Biofilms / growth & development; Escherichia coli / genetics; Escherichia coli / growth & development; Escherichia coli / metabolism; Escherichia coli / physiology; Fimbriae Proteins / genetics; Fimbriae Proteins / metabolism; Fimbriae, Bacterial / genetics; Fimbriae, Bacterial / metabolism; Humans; Immunoglobulin A, Secretory / immunology; Immunoglobulin A, Secretory / metabolism; Mannose
TL;DR: It is found that the aggregation of E. coli K-12 by human secretory IgA (SIgA) was dependent on the presence of the pilus fiber, even in the absence of the mannose specific adhesin or in the Presence of 25 mM α-CH3Man. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

A humoral immune response confers protection against Haemophilus ducreyi infection

INFECTION AND IMMUNITY, 71(12), 6971–6977.

By: L. Cole*, K. Toffer*, R. Fulcher*, L. San Mateo*, P. Orndorff n & T. Kawula *

MeSH headings : Animals; Antibodies, Bacterial / blood; Antibodies, Bacterial / immunology; Antibody Specificity; Chancroid / immunology; Chancroid / microbiology; Chancroid / prevention & control; Colony Count, Microbial; Disease Models, Animal; Female; Haemophilus Vaccines / administration & dosage; Haemophilus Vaccines / immunology; Haemophilus ducreyi / immunology; Haemophilus ducreyi / isolation & purification; Haemophilus ducreyi / pathogenicity; Humans; Immune Sera / immunology; Immunization, Passive; Immunoglobulin G / blood; Immunoglobulin G / immunology; Swine; Swine Diseases / immunology; Swine Diseases / microbiology; Swine Diseases / prevention & control; Vaccination
TL;DR: After three successive inoculations with H. ducreyi, pigs developed a modestly protective immune response evidenced by the decreased recovery of viable bacteria from lesions, and immune sera were protective when administered to naïve pigs prior to challenge with the organism. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Influence of extracellular bactericidal agents on bacteria within macrophages

INFECTION AND IMMUNITY, 71(2), 1016–1019.

By: T. Hamrick n, A. Diaz n, E. Havell n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Escherichia coli / metabolism; Animals; Anti-Bacterial Agents / pharmacology; Bacteriophage lambda / pathogenicity; Drug Resistance, Bacterial; Escherichia coli / drug effects; Escherichia coli / growth & development; Escherichia coli / virology; Fimbriae Proteins / metabolism; Gentamicins / pharmacology; Macrophages, Peritoneal / microbiology; Mice; Mice, Inbred BALB C; Phagocytosis
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Influence of pregnancy on the pathogenesis of listeriosis in mice inoculated intragastrically

INFECTION AND IMMUNITY, 71(9), 5202–5209.

By: T. Hamrick n, . Horton  n, P. Spears n, E. Havell n, I. Smoak n & P. Orndorff n

MeSH headings : Animals; Base Sequence; Colon / microbiology; Colony Count, Microbial; DNA, Bacterial / genetics; Enterocytes / microbiology; Female; Listeria monocytogenes / genetics; Listeria monocytogenes / isolation & purification; Listeria monocytogenes / pathogenicity; Listeriosis / complications; Listeriosis / etiology; Liver / microbiology; Mice; Mutagenesis, Insertional; Pregnancy; Pregnancy Complications, Infectious / etiology; Risk Factors; Spleen / microbiology; Virulence / genetics
TL;DR: The ability of the 4nonb strain to produce a lethal infection in pregnant animals did not correlate with an increased incidence or level of liver and spleen colonization over that in nonpregnant females, but the lethality rate did correlate well with the rate at which embryos and their surrounding decidual covering became infected, suggesting that intrauterine infection could be responsible for the increased disease severity in the gravid females. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

The product of the fimI gene is necessary for Escherichia coli type 1 pilus biosynthesis

JOURNAL OF BACTERIOLOGY, 185(16), 5007–5011.

By: M. Valenski n, S. Harris n, P. Spears n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Escherichia coli / genetics; Adhesins, Escherichia coli / metabolism; Alleles; Escherichia coli / genetics; Escherichia coli / metabolism; Fimbriae Proteins / genetics; Fimbriae Proteins / metabolism; Fimbriae, Bacterial / metabolism; Frameshift Mutation; Genetic Complementation Test; Molecular Sequence Data; Mutagenesis, Insertional; Mutagenesis, Site-Directed
TL;DR: FimI has a required role in normal pilus biosynthesis and site-directed mutagenesis indicated that it produced polarity-like effects not seen with an in-frame fimI deletion mutation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Unexpected similarities between Bordetella avium and other pathogenic bordetellae

INFECTION AND IMMUNITY, 71(5), 2591–2597.

By: P. Spears n, L. Temple*, D. Miyamoto*, D. Maskell * & P. Orndorff n

MeSH headings : Amino Acid Sequence; Animals; Bacterial Proteins; Bird Diseases / microbiology; Bordetella / genetics; Bordetella / pathogenicity; Bordetella Infections / microbiology; Bordetella Infections / veterinary; Bordetella bronchiseptica / genetics; Bordetella bronchiseptica / pathogenicity; Bordetella pertussis / genetics; Bordetella pertussis / pathogenicity; Fimbriae Proteins / genetics; Fimbriae Proteins / physiology; Genes, Bacterial / physiology; Genotype; Molecular Sequence Data; Mutation; Phenotype; Turkeys / microbiology
TL;DR: The findings strengthen the connection between the causative agents and the pathogenesis of bordetellosis in all hosts and may help explain the striking similarities of the histopathologic characteristics of this upper airway disease in avian and mammalian species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

BhuR, a virulence-associated outer membrane protein of Bordetella avium, is required for the acquisition of iron from heme and hemoproteins

INFECTION AND IMMUNITY, 70(10), 5390–5403.

By: E. Murphy *, R. Sacco*, A. Dickenson*, D. Metzger*, Y. Hu *, P. Orndorff n, T. Connell*

MeSH headings : Amino Acid Sequence; Animals; Bacterial Outer Membrane Proteins / chemistry; Bacterial Outer Membrane Proteins / genetics; Bacterial Outer Membrane Proteins / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Base Sequence; Bordetella / genetics; Bordetella / metabolism; Bordetella / pathogenicity; Bordetella Infections / etiology; Bordetella Infections / veterinary; Cloning, Molecular; DNA, Bacterial / genetics; Genes, Bacterial; Genetic Complementation Test; Heme / metabolism; Hemeproteins / metabolism; Hemin / metabolism; Humans; Iron / metabolism; Molecular Sequence Data; Mutation; Poultry Diseases / etiology; Protein Structure, Tertiary; Receptors, Cell Surface / genetics; Receptors, Cell Surface / metabolism; Turkeys; Virulence / genetics; Virulence / physiology
TL;DR: Genetic manipulations of B. avium confirmed that bhuR, which encodes a putative outer membrane heme receptor, mediates efficient acquisition of Fe from hemin and hemoproteins (hemoglobin, myoglobin, and catalase) and was established in turkey poults by use of a competitive-infection model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Use of bacteriophage Ba1 to identify properties associated with Bordetella avium virulence

Infection and Immunity, 70(3), 1219–1224.

By: C. Shelton, L. Temple & P. Orndorff

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Characterization of Escherichia coli type 1 pilus mutants with altered binding specificities

JOURNAL OF BACTERIOLOGY, 183(13), 4099–4102.

By: S. Harris n, P. Spears n, E. Havell n, T. Hamrick n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Bacterial / metabolism; Adhesins, Escherichia coli; Alleles; Chromosomes, Bacterial; Escherichia coli / physiology; Fimbriae Proteins; Fimbriae, Bacterial / genetics; Fimbriae, Bacterial / metabolism; Molecular Sequence Data; Mutation; Phenotype; Plasmids; Recombination, Genetic
TL;DR: PCR mutagenesis and a unique enrichment scheme were used to obtain two mutants, each with a single lesion in fimH, the chromosomal gene that encodes the adhesin protein (FimH) of Escherichia coli type 1 pili that were noteworthy in part because both were altered in the normal range of cell types bound by FimH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Formation of antibiotic, biodegradable polymers by processing with Irgasan DP300R (Triclosan) and its inclusion compound with beta-cyclodextrin

Journal of Applied Polymer Science, 82(2), 300–309.

By: J. Lu n, M. Hill n, M. Hood n, D. Greeson n, J. Horton n, P. Orndorff n, A. Herndon n, A. Tonelli n

UN Sustainable Development Goal Categories
Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

A role for lipopolysaccharide in turkey tracheal colonization by Bordetella avium as demonstrated in vivo and in vitro

MOLECULAR MICROBIOLOGY, 36(6), 1425–1435.

By: P. Spears n, L. Temple* & P. Orndorff n

MeSH headings : Animals; Bordetella / genetics; Bordetella / growth & development; Bordetella / isolation & purification; Bordetella / pathogenicity; Bordetella Infections / microbiology; Bordetella Infections / veterinary; Genes, Bacterial; Genetic Complementation Test; Lipopolysaccharides / metabolism; Phenotype; Plasmids; Trachea / microbiology; Turkeys
TL;DR: This is the first characterization of LPS mutants of B. avium at the genetic level and the first report of virulence changes by both in vivo and in vitro measurements. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Characterization of Lyme disease spirochetes isolated from ticks and vertebrates in North Carolina

JOURNAL OF WILDLIFE DISEASES, 36(1), 48–55.

By: . Ryan n, C. Apperson n, P. Orndorff n & J. Levine n 

author keywords: Borrelia burgdorferi; isolate characterization; Lyme disease; ticks; vertebrates
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Arachnid Vectors / microbiology; Bacterial Outer Membrane Proteins / analysis; Bacterial Outer Membrane Proteins / immunology; Blotting, Western / veterinary; Borrelia burgdorferi Group / classification; Borrelia burgdorferi Group / genetics; Borrelia burgdorferi Group / immunology; Chickens / microbiology; DNA, Bacterial / analysis; Disease Reservoirs; Dogs; Electrophoresis, Polyacrylamide Gel / veterinary; Lizards / microbiology; North Carolina; Plasmids / chemistry; Rabbits / microbiology; Raccoons / microbiology; Rodentia / microbiology; Species Specificity; Ticks / microbiology; Vertebrates / microbiology
TL;DR: This study demonstrates that B. burgdorferi sensu stricto is present and naturally transmitted on the Outer Banks and in the Coastal Plain and Piedmont regions of North Carolina. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Discovery, purification, and characterization of a temperate transducing bacteriophage for Bordetella avium

JOURNAL OF BACTERIOLOGY, 182(21), 6130–6136.

By: C. Shelton n, D. Crosslin n, J. Casey n, S. Ng*, L. Temple* & P. Orndorff n

MeSH headings : Bacteriophages / genetics; Bacteriophages / isolation & purification; Bacteriophages / ultrastructure; Bordetella / virology; Centrifugation, Density Gradient; DNA, Viral / analysis; Humans; Lysogeny; Mutagenesis, Insertional; Replicon; Transduction, Genetic
TL;DR: UV irradiation of transducing lysates markedly improved transduction frequency and reduced the number of transductants that were lysogenized during the transduction process, suggesting that transduction was generalized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Experimental Salmonella typhi infection in the domestic pig, Sus scrofa domestica

MICROBIAL PATHOGENESIS, 29(2), 121–126.

By: E. Metcalf*, G. Almond n , P. Routh n, . Horton  n, R. Dillman n & P. Orndorff n

author keywords: Salmonella; typhi; choleraesuis; pig; tonsil; typhoid fever
MeSH headings : Animals; Disease Models, Animal; Female; Humans; Palatine Tonsil / microbiology; Salmonella / growth & development; Salmonella / pathogenicity; Salmonella Infections, Animal / microbiology; Salmonella typhi / growth & development; Salmonella typhi / pathogenicity; Swine; Swine Diseases / microbiology; Typhoid Fever / microbiology; Virulence
TL;DR: The observation of tonsillar involvement was consistent with former observations of S. choleraesuis and S. typhimurium infections in swine and supports a role for the tonsil in all porcine salmonella infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Genetic characterization of Escherichia coli type 1 pilus adhesin mutants and identification of a novel binding phenotype

JOURNAL OF BACTERIOLOGY, 182(14), 4012–4021.

By: T. Hamrick n, S. Harris n, P. Spears n, E. Havell n, . Horton  n, P. Russell n, P. Orndorff n

MeSH headings : Adhesins, Bacterial / genetics; Adhesins, Escherichia coli; Animals; Bacterial Adhesion / genetics; Base Sequence; Chromosome Mapping; Erythrocytes / microbiology; Escherichia coli / genetics; Escherichia coli / pathogenicity; Fimbriae Proteins; Guinea Pigs; Hemagglutination Tests; Macrophages / microbiology; Mice; Molecular Sequence Data; Phenotype; Point Mutation
TL;DR: Temperature shift experiments revealed that new FimH biosynthesis was required for the phenotypic change, and a temperature-sensitive (ts) fimH mutant that agglutinated guinea pig erythrocytes but not at 42 degrees C was chosen for further study. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Host and bacterial factors involved in the innate ability of mouse macrophages to eliminate internalized unopsonized Escherichia coli

INFECTION AND IMMUNITY, 68(1), 125–132.

By: T. Hamrick n, E. Havell n, . Horton  n & P. Orndorff n

MeSH headings : Adhesins, Bacterial / immunology; Adhesins, Escherichia coli; Animals; Cell Line; Cytotoxicity, Immunologic; Escherichia coli / immunology; Fimbriae Proteins; Macrophages, Peritoneal / immunology; Macrophages, Peritoneal / microbiology; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Phagocytosis; Species Specificity
TL;DR: Host and bacterial factors involved in the nonopsonic phagocytosis and killing of Escherichia coli K-12 by mouse macrophages were examined to better understand genetic and cellular factors that influence innate immunity and there was no correlation between the bacteriocidal effectiveness of amacrophage population and the number of bacteria bound per macrophage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Formation of antibiotic, biodegradable/bioabsorbable polymers by processing with neomycin sulfate and its inclusion compound with beta-cyclodextrin

JOURNAL OF APPLIED POLYMER SCIENCE, 74(4), 937–947.

By: L. Huang n, H. Taylor n, M. Gerber n, P. Orndorff n, . Horton  n & A. Tonelli n

TL;DR: Since an antibiotic, bioabsorbable suture does not require surgical removal, implanting an inclusion compound in the suture might allow the slow release of antibiotic, thereby guarding against postsurgical infection and also protecting the antibiotic from degradation during the melt-spinning process used to make the sutures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Immune cells are required for cutaneous ulceration in a swine model of chancroid

Infection and Immunity, 67(9), 4963–4967.

By: L. San Mateo, K. Toffer, P. Orndorff & T. Kawula

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

Neutropenia restores virulence to an attenuated Cu,Zn superoxide dismutase-deficient Haemophilus ducreyi strain in the swine model of chancroid

Infection and Immunity, 67(10), 5345–5351.

By: L. San Mateo, K. Toffer, P. Orndorff & T. Kawula

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

An experimental chain of infection reveals that distinct Borrelia burgdorferi populations are selected in arthropod and mammalian hosts

MOLECULAR MICROBIOLOGY, 30(2), 365–379.

By: . Ryan n, J. Levine n , C. Apperson n, L. Lubke*, R. Wirtz*, P. Spears n, P. Orndorff n

MeSH headings : Amino Acid Sequence; Animals; Antigenic Variation; Antigens, Bacterial; Antigens, Surface / genetics; Bacterial Outer Membrane Proteins / genetics; Borrelia Infections / transmission; Borrelia burgdorferi Group / genetics; Borrelia burgdorferi Group / immunology; Borrelia burgdorferi Group / pathogenicity; Genetics, Population; Host-Parasite Interactions; Mice; Molecular Sequence Data; Plasmids; Rabbits; Rats; Selection, Genetic; Species Specificity; Ticks / microbiology
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Bordetella avium virulence measured in vivo and in vitro

Infection and Immunity, 66(11), 5244–5251.

By: L. Temple, A. Weiss, K. Walker, H. Barnes, V. Christensen, D. Miyamoto, C. Shelton, P. Orndorff

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Shigella infection as observed in the experimentally inoculated domestic pig, Sus scrofa domestica

MICROBIAL PATHOGENESIS, 25(4), 189–196.

By: A. Maurelli *, P. Routh n, R. Dillman n, M. Ficken n, D. Weinstock  n, G. Almond n , P. Orndorff n

author keywords: Shigella; model; colonization; pig; tonsil; dysentery
MeSH headings : Age Factors; Animals; Disease Models, Animal; Dysentery, Bacillary / microbiology; Humans; Immunohistochemistry; Rectum / microbiology; Shigella dysenteriae / growth & development; Shigella dysenteriae / pathogenicity; Shigella flexneri / growth & development; Shigella flexneri / pathogenicity; Species Specificity; Swine; Time Factors; Virulence
TL;DR: The results indicate that the domestic pig is unsuitable as a model for shigellosis, and virulent and avirulent strains of S. flexneri were utilized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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