Peter Joseph Early

Works (39)

Updated: September 4th, 2024 05:01

2024 article

Clinical and imaging findings in dogs with nerve root signature associated with cervical intervertebral disc herniation

Schachar, J., Bocage, A., Nelson, N. C., Early, P. J., Mariani, C. L., Olby, N. J., & Munana, K. R. (2024, January 12). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 1.

By: J. Schachar n, A. Bocage n, N. Nelson n, P. Early n, C. Mariani n , N. Olby n , K. Munana n 

author keywords: cervical radiculopathy; intraforaminal disc herniation; magnetic resonance imaging; thoracic limb lameness
TL;DR: NRS is most prevalent with C6‐C7 intervertebral disc involvement, suggesting that there might be unique anatomic factors that contribute to development of NRS at this site, but can be a clinical manifestation of IVDH occurring anywhere along the cervical spine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 13, 2024

2024 article

Pharmacokinetics of subcutaneous ketamine administration via the Omnipod® system in dogs

Colon, C., Early, P., Munana, K., Olby, N., Mariani, C., Mancini, S., … Messenger, K. (2024, March 27). JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, Vol. 3.

By: C. Colon  n, P. Early n, K. Munana n , N. Olby n , C. Mariani n , S. Mancini n, G. Fefer n, Z. Li * ...

author keywords: analgesia; canine; ketamine; novel; veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 journal article

Quantification of metallic artifact on CT associated with titanium pedicle screws

FRONTIERS IN VETERINARY SCIENCE, 11.

By: M. Lewis n, P. Early n, R. Bergman*, K. Love & N. Nelson n

author keywords: vertebral column; dog; canal breach; bloom artifact; stabilization
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 26, 2024

2024 journal article

Surgical management of a lumbar far lateral intervertebral disc extrusion in a cat

JOURNAL OF FELINE MEDICINE AND SURGERY OPEN REPORTS, 10(2).

By: G. Fefer n, L. Bynum n & P. Early n

author keywords: Foraminotomy; foraminal; intervertebral disc extrusion; lameness; surgery
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 14, 2024

2023 article

Chronic, progressive paraparesis and acute paraplegia in an 8-year-old Australian Shepherd mixed-breed dog

Kei, T. G., Korff, C. P., Porter, I. R., & Early, P. J. (2023, June). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 261.

By: T. Kei*, C. Korff *, I. Porter * & P. Early n

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: November 13, 2023

2023 journal article

Craniectomies for Dogs With Skull Multilobular Osteochondrosarcoma Using the Misonix Bone Scalpel: Cadaveric Evaluation and Retrospective Case Series

TOPICS IN COMPANION ANIMAL MEDICINE, 53.

By: A. Piazza *, J. McAnulty *, P. Early n & J. Guevar*

author keywords: piezoelectric; bone scalpel; osteochondrosarcoma; dog
MeSH headings : Dogs; Animals; Retrospective Studies; Osteosarcoma / diagnosis; Osteosarcoma / veterinary; Skull / surgery; Bone Neoplasms / surgery; Bone Neoplasms / veterinary; Craniotomy / veterinary; Sarcoma / surgery; Sarcoma / veterinary; Dog Diseases / drug therapy
TL;DR: Piezoelectric bone surgery with the Misonix bone scalpel is an alternative technology to perform craniectomies in dogs and was not associated with complications in 3 dogs diagnosed and surgically treated for MLO. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 12, 2023

2023 journal article

Magnetic resonance imaging characteristics of atlanto-axial subluxation in 42 dogs: Analysis of joint cavity size, subluxation distance, and craniocervical junction anomalies

OPEN VETERINARY JOURNAL, 13(9), 1091–1098.

By: K. Bray *, S. Platt, M. Kent *, N. Olby n , P. Early n, C. Mariani n , K. Munana n , S. Holmes

author keywords: Canine; Cervical; Congenital; Malformation; Myelopathy
TL;DR: Dogs with clinical signs of AA subluxation were significantly more likely to have intramedullary hyperintensity at the level of compression, an increased AA joint cavity size, and increased spinal cord compression at thelevel of dens and mid-body C2, according to MRI characteristics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 16, 2024

2023 article

Presumed pituitary apoplexy in 26 dogs: Clinical findings, treatments, and outcomes

Woelfel, C. W., Mariani, C. L., Nolan, M. W., Keenihan, E. K., Topulos, S. P., Early, P. J., … Olby, N. J. (2023, April 21). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 4.

By: C. Woelfel n, C. Mariani n , M. Nolan n, E. Keenihan n, S. Topulos n, P. Early n, K. Munana n , S. Musulin n , N. Olby n 

author keywords: adenoma; carcinoma; endocrionopathy; hemorrhage; magnetic resonance imaging; suprasellar; survival
MeSH headings : Dogs; Animals; Pituitary Apoplexy / therapy; Pituitary Apoplexy / veterinary; Pituitary Apoplexy / diagnosis; Pituitary Neoplasms / complications; Pituitary Neoplasms / diagnostic imaging; Pituitary Neoplasms / therapy; Pituitary Neoplasms / veterinary; Retrospective Studies; Hydrocephalus / veterinary; Infarction / veterinary; Magnetic Resonance Imaging / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / therapy
TL;DR: Dogs with pituitary apoplexy present with a variety of acute signs of neurological disease and inconsistent endocrine dysfunction and dogs that survive to discharge can have a favorable outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 22, 2023

2022 journal article

Diagnostic traction and dorsal locking plate stabilization of a fifth and sixth thoracic vertebral fracture/luxation in a golden retriever: Case report

FRONTIERS IN VETERINARY SCIENCE, 9.

By: W. Tammaro*, P. Early n, R. Bergman*, B. Petrovsky & K. Kraus*

author keywords: diagnostic traction; dorsal locking plates; spinal stabilization; thoracic vertebral fracture; luxation; case report
TL;DR: This case demonstrates that diagnostic traction—the process of pulling, during imaging, on the dog's pelvis while the forelimbs are secured in extension—demonstrated instability of the spine which was not readily apparent on initial CT imaging. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 23, 2023

2022 journal article

Novel subcutaneous cytarabine infusion with the Omnipod system in dogs with meningoencephalomyelitis of unknown etiology

AMERICAN JOURNAL OF VETERINARY RESEARCH, 83(9).

By: S. Mancini n, P. Early n, B. Slater*, N. Olby n , C. Mariani n , K. Munana n , C. Woelfel n, J. Schacher n, L. Zhong *, K. Messenger n

MeSH headings : Animals; Area Under Curve; Chromatography, High Pressure Liquid / veterinary; Cytarabine / therapeutic use; Dogs; Half-Life; Humans; Infusions, Intravenous / veterinary; North Carolina
TL;DR: An SC continuous-rate infusion of cytarabine via the Omnipod system is feasible in dogs and was able to achieve a steady-state concentration of more than 1 μg/mL 4 to 10 hours postinitiation of cyTarabine and a Cmax of 7,510 ng/mL, comparable to values reported previously with IV continuous- rate infusion administration in healthy research Beagles and dogs with meningoencephalomyelitis of unknown etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 1, 2022

2021 article

Computed tomography evaluation of proposed implant corridors in canine thoracic vertebrae

Schmitt, E. M., Early, P., Bergman, R., Riedesel, E. A., Yuan, L., Mochel, J. P., & Kraus, K. H. (2021, July 12). VETERINARY SURGERY.

By: E. Schmitt*, P. Early n, R. Bergman*, E. Riedesel*, L. Yuan*, J. Mochel *, K. Kraus*

MeSH headings : Animals; Bone Nails; Dogs; Retrospective Studies; Thoracic Vertebrae / diagnostic imaging; Tomography, X-Ray Computed / veterinary
TL;DR: Corridor trajectories identified in this population can be achieved from a dorsal approach between T5 and T9 due to the variability found in these vertebrae as well as regional anatomical constraints. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: July 19, 2021

2021 journal article

Outcomes and prognostic indicators in 59 paraplegic medium to large breed dogs with extensive epidural hemorrhage secondary to thoracolumbar disc extrusion

VETERINARY SURGERY, 50(3), 527–536.

By: C. Woelfel n, J. Robertson n , C. Mariani n , K. Munana n , P. Early n & N. Olby n 

MeSH headings : Animals; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / surgery; Dogs; Female; Hematoma, Epidural, Spinal / complications; Hematoma, Epidural, Spinal / surgery; Hematoma, Epidural, Spinal / veterinary; Intervertebral Disc Degeneration / complications; Intervertebral Disc Degeneration / surgery; Intervertebral Disc Degeneration / veterinary; Laminectomy / statistics & numerical data; Laminectomy / veterinary; Male; Paraplegia / diagnosis; Paraplegia / surgery; Paraplegia / veterinary; Prognosis; Recovery of Function; Retrospective Studies; Species Specificity; Treatment Outcome; Walking
TL;DR: Paraplegic medium to large breed dogs with DEEH have a less favorable outcome after surgical decompression than paraplegic dogs with TL-IVDE, and loss of pain perception and increased HASTEi are associated with a poor outcome, while more extensive decompression improves outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 8, 2021

2021 article

Subaxial cervical articular process subluxation and dislocation: Cervical locked facet injuries in dogs

Woelfel, C. W., Bray, K. Y., Early, P. J., Mariani, C. L., & Olby, N. J. (2021, November 24). VETERINARY SURGERY, Vol. 11.

By: C. Woelfel n, K. Bray*, P. Early n, C. Mariani n  & N. Olby n 

MeSH headings : Animals; Cervical Vertebrae; Dogs; Joint Dislocations / veterinary; Neck; Retrospective Studies
TL;DR: In these dogs, locked facet injuries affected the caudal cervical vertebrae in small breeds and could be identified on imaging through the presence of dorsal displacement of a cranial articular process. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 6, 2021

2021 journal article

Surgical Resection of a Parietal Osteoma in a Domestic Ferret Using Advanced Neurosurgical Techniques

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 57(2), 91–95.

By: A. Paushter*, P. Early*, T. Perkins & J. Applegate*

MeSH headings : Animals; Bone Neoplasms / diagnostic imaging; Bone Neoplasms / surgery; Bone Neoplasms / veterinary; Ferrets; Male; Neurosurgical Procedures; Osteoma / diagnostic imaging; Osteoma / surgery; Osteoma / veterinary; Parietal Bone; Ultrasonography, Interventional
TL;DR: This is one of only two reports in the literature to document the surgical removal of an osteoma in a ferret, and this is the sole case in which a custom apparatus was fabricated for head stabilization, a multiaxis adjustable surgical table was used to improve access to the surgical site, and an ultrasonic scalpel was used for the mass resection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: March 29, 2021

2021 journal article

Ultrasound-guided paravertebral perineural glucocorticoid injection for signs of refractory cervical pain associated with foraminal intervertebral disk protrusion in four dogs

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 258(9), 999–1006.

By: J. Wolf n, P. Early n, A. Pozzi * & A. Vigani n

MeSH headings : Animals; Cervical Vertebrae; Dog Diseases / drug therapy; Dogs; Glucocorticoids; Intervertebral Disc; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Neck Pain / veterinary; Ultrasonography, Interventional / veterinary
TL;DR: Findings indicated that ultrasound-guided paravertebral perineural injection can be an effective treatment of cervical foraminal IVDP for some dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2021 personal communication

Ultrasound-guided perineural injections for the medical management of thoracic limb root signature in a dog

Chiavaccini, L., Schachar, J., Early, P. J., & Bailey, K. M. (2021, May).

By: L. Chiavaccini n, J. Schachar n, P. Early n & K. Bailey n

MeSH headings : Animals; Dogs; Injections / veterinary; Nerve Block / veterinary; Ultrasonography / veterinary; Ultrasonography, Interventional / veterinary
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: June 10, 2021

2021 article

Vascular endothelial growth factor concentrations in the cerebrospinal fluid of dogs with neoplastic or inflammatory central nervous system disorders

Mariani, C. L., Niman, Z. E., Boozer, L. B., Ruterbories, L. K., Early, P. J., Munana, K. R., & Olby, N. J. (2021, June 9). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 6.

By: C. Mariani n , Z. Niman n, L. Boozer n, L. Ruterbories n, P. Early n, K. Munana n , N. Olby n 

author keywords: biomarker; brain tumor; meningoencephalitis; meningomyelitis
MeSH headings : Animals; Case-Control Studies; Central Nervous System Diseases / veterinary; Cerebrospinal Fluid; Dog Diseases; Dogs; Hospitals, Animal; Hospitals, Teaching; Vascular Endothelial Growth Factor A
TL;DR: Concentrations of VEGF in CSF are higher in dogs with central nervous system (CNS) neoplasia compared to those with meningoencephalomyelitis and other neurologic disorders and may serve as a marker of neoplastic and inflammatory CNS disorders relative to other conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 10, 2021

2020 journal article

Influence of Duration of Injury on Diffusion Tensor Imaging in Acute Canine Spinal Cord Injury

JOURNAL OF NEUROTRAUMA, 37(21), 2261–2267.

By: M. Lewis*, P. Early n, C. Mariani n , K. Munana n  & N. Olby n 

author keywords: dog; fractional anisotropy; imaging biomarker; intervertebral disc herniation; mean diffusivity
MeSH headings : Animals; Diffusion Tensor Imaging / methods; Dogs; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Spinal Cord Injuries / diagnostic imaging; Spinal Cord Injuries / pathology; Spinal Cord Injuries / veterinary; Time Factors
TL;DR: Investigating the impact of duration of injury on DTI indices in dogs with acute, spontaneous SCI due to thoracolumbar intervertebral disc herniation and explore associations with clinical severity found MD might differentiate injury severity in the acute setting and be worthy of development as an imaging biomarker. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020

2020 journal article

Traumatic skull fractures in dogs and cats: A comparative analysis of neurological and computed tomographic features

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(5), 1975–1985.

By: P. Amengual-Batle*, R. Jose-Lopez *, A. Durand n, M. Czopowicz *, E. Beltran *, J. Guevar n, K. Lazzerini *, S. De Decker * ...

author keywords: canine; computed tomography; feline; skull fractures
MeSH headings : Animals; Cat Diseases / diagnostic imaging; Cats; Dog Diseases / diagnostic imaging; Dogs; Retrospective Studies; Skull / diagnostic imaging; Skull Fractures / diagnostic imaging; Skull Fractures / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: The cranial vault fractures were associated with neurological deficits and worse survival, and the presence of TSF alone should not be considered a negative prognostic factor because most affected animals survived the first week. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020

2019 journal article

Risk factors associated with progressive myelomalacia in dogs with complete sensorimotor loss following intervertebral disc extrusion: a retrospective case-control study

BMC Veterinary Research, 15(1).

By: A. Castel*, N. Olby n , H. Ru n, C. Mariani n , K. Muñana n  & P. Early n

author keywords: Ascending-descending myelomalacia; Spinal cord injury; Intervertebral disk disease; Paraplegia
MeSH headings : Animals; Case-Control Studies; Dog Diseases / etiology; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Logistic Models; Male; Multivariate Analysis; Paraplegia / etiology; Paraplegia / physiopathology; Paraplegia / veterinary; Retrospective Studies; Risk Factors; Spinal Cord Diseases / etiology; Spinal Cord Diseases / pathology; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary
TL;DR: Dogs with lumbar intumescence IVDE are at increased risk of progressive myelomalacia and timing of surgery and corticosteroid use warrant further investigations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: February 10, 2020

2019 journal article

Surgical decompression, with or without adjunctive therapy, for palliative treatment of primary vertebral osteosarcoma in dogs

VETERINARY AND COMPARATIVE ONCOLOGY, 17(4), 472–478.

By: A. Dixon *, A. Chen *, J. Rossmeisl *, B. Sturges*, K. Vernau *, J. Levine *, A. Otamendi*, P. Early n ...

author keywords: laminectomy; osteosarcoma; spine
MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Bone Neoplasms / therapy; Bone Neoplasms / veterinary; Decompression, Surgical / veterinary; Dog Diseases / therapy; Dogs; Osteosarcoma / therapy; Osteosarcoma / veterinary; Palliative Care; Retrospective Studies; Survival Analysis
TL;DR: It is suggested that definitive radiation therapy, possibly combined with concurrent chemotherapy, significantly improves survival in dogs treated with palliative decompressive surgery for vertebral OSA and should be the treatment of choice in selected cases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 18, 2019

2018 journal article

A randomized, blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation

Journal of Veterinary Internal Medicine, 32(3), 1133–1144.

By: N. Zidan n, C. Sims n, J. Fenn *, K. Williams  n, E. Griffith n, P. Early n, C. Mariani n , K. Munana n  ...

author keywords: ataxia; gait training; locomotion; plasticity; spinal cord injury
MeSH headings : Animals; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Intervertebral Disc Displacement / rehabilitation; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lumbar Vertebrae / surgery; Male; Postoperative Care / veterinary; Recovery of Function; Thoracic Vertebrae / surgery
TL;DR: Early postoperative rehabilitation after surgery for TL‐IVDH is safe but doesn't improve rate or level of recovery in dogs with incomplete SCI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2018 journal article

The Effect of Electromagnetic Fields on Post-Operative Pain and Locomotor Recovery in Dogs with Acute, Severe Thoracolumbar Intervertebral Disc Extrusion: A Randomized Placebo-Controlled, Prospective Clinical Trial

Journal of Neurotrauma, 35(15), 1726–1736.

By: N. Zidan n, J. Fenn *, E. Griffith n, P. Early n, C. Mariani n , K. Muñana n , J. Guevar n, N. Olby n 

Contributors: N. Zidan n, J. Fenn *, E. Griffith n, P. Early n, C. Mariani n , K. Muñana n , J. Guevar n, N. Olby n 

author keywords: biomarker; GFAP; hemilaminectomy; pain; spinal cord injury
MeSH headings : Animals; Decompression, Surgical; Dog Diseases / therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / surgery; Lumbar Vertebrae; Magnetic Field Therapy / methods; Male; Pain, Postoperative / etiology; Pain, Postoperative / therapy; Random Allocation; Recovery of Function / radiation effects; Spinal Cord Injuries / etiology; Spinal Cord Injuries / therapy; Thoracic Vertebrae
TL;DR: It is concluded that PEMF reduced incision-associated pain in dogs post-surgery for IVDE and may reduce extent of SCI and enhance proprioceptive placing. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2018 journal article

The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology

Journal of Veterinary Pharmacology & Therapeutics, 41(5), 638–643.

By: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n , A. Maller*, K. Bray *, R. Waldron*, A. Castel * ...

Contributors: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n , A. Maller*, K. Bray *, R. Waldron*, A. Castel * ...

author keywords: canine; cytarabine; MUE; Pharmacokinetics; sparse sampling; subcutaneous; canine; cytarabine; MUE; pharmacokinetics; sparse sampling; subcutaneous
MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Antimetabolites, Antineoplastic / therapeutic use; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Cytarabine / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Combinations; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / therapeutic use; Injections, Subcutaneous; Male; Meningoencephalitis / drug therapy; Meningoencephalitis / veterinary; Prednisone / administration & dosage; Prednisone / blood; Prednisone / pharmacokinetics; Prednisone / therapeutic use
TL;DR: The pharmacokinetics of CA in dogs with MUE after a single 50 mg/m2 SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018

2017 journal article

Associations Between Anesthetic Variables and Functional Outcome in Dogs With Thoracolumbar Intervertebral Disk Extrusion Undergoing Decompressive Hemilaminectomy

Journal of Veterinary Internal Medicine, 31(3), 814–824.

By: J. Fenn *, E. Laber n, K. Williams n, C. Rousse n, P. Early n, C. Mariani n , K. Munana n , S. Decker * ...

Contributors: J. Fenn *, E. Laber n, K. Williams n, C. Rousse n, P. Early n, C. Mariani n , K. Muñana n , S. De Decker *, H. Volk *, N. Olby n 

author keywords: Anesthesia; Canine; Intervertebral disk extrusion; Prognosis; Spinal cord injury
MeSH headings : Anesthesia, General / adverse effects; Anesthesia, General / methods; Anesthesia, General / veterinary; Animals; Bradycardia / chemically induced; Bradycardia / veterinary; Decompression, Surgical / methods; Decompression, Surgical / veterinary; Dog Diseases / surgery; Dogs; Female; Hypotension / chemically induced; Hypotension / veterinary; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Laminectomy / methods; Laminectomy / veterinary; Male; Retrospective Studies; Thoracic Vertebrae / surgery; Treatment Outcome
TL;DR: Across all outcome measures, regression tree analysis highlighted functional grade at presentation as the primary determining factor, and among pain perception negative dogs, there was a possible association between increased duration of surgery and poorer outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2017 journal article

Clinical Characteristics of Dogs with Progressive Myelomalacia Following Acute Intervertebral Disc Extrusion

Journal of Veterinary Internal Medicine, 31(6), 1782–1789.

By: A. Castel n, N. Olby n , C. Mariani n , K. Muñana n  & P. Early n

Contributors: A. Castel n, N. Olby n , C. Mariani n , K. Muñana n  & P. Early n

author keywords: Ascending-descending myelomalacia; Intervertebral disc disease; Spinal cord injury
MeSH headings : Animals; Disease Progression; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Female; Intervertebral Disc Degeneration / diagnostic imaging; Intervertebral Disc Degeneration / pathology; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / diagnostic imaging; Intervertebral Disc Displacement / pathology; Intervertebral Disc Displacement / veterinary; Magnetic Resonance Imaging / veterinary; Male; Myelography / veterinary; Retrospective Studies; Spinal Cord Diseases / mortality; Spinal Cord Diseases / pathology; Spinal Cord Diseases / veterinary; Tomography, X-Ray Computed / veterinary
TL;DR: The majority of dogs developed PMM within 2 days of presentation and was euthanized within another 3 days, however, onset can be delayed up to 5 days after presentation with progression to euthanasia taking as long as 2 weeks. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Clinical and Diagnostic Imaging Features of Brain Herniation in Dogs and Cats

Journal of Veterinary Internal Medicine, 30(5), 1672–1680.

By: M. Lewis n, N. Olby n , P. Early n, C. Mariani n , K. Muñana n , G. Seiler n, E. Griffith n

MeSH headings : Animals; Body Size; Brain / diagnostic imaging; Brain / pathology; Cat Diseases / diagnostic imaging; Cat Diseases / pathology; Cats; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Magnetic Resonance Imaging / veterinary; Retrospective Studies
TL;DR: Brain herniation can be quantified on MRI and more severe CTH based on TTX is associated with a worse short‐term outcome, compared with more severe foramen magnum based on FMH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2016 journal article

Effect of Cranberry Extract on the Frequency of Bacteriuria in Dogs with Acute Thoracolumbar Disk Herniation: A Randomized Controlled Clinical Trial

Journal of Veterinary Internal Medicine, 31(1), 60–68.

By: N. Olby n , S. Vaden n, K. Williams n, E. Griffith n, T. Harris n, C. Mariani n , K. Muñana n , P. Early n ...

Contributors: N. Olby n , S. Vaden n, K. Williams n, E. Griffith n, T. Harris n, C. Mariani n , K. Muñana n , P. Early n ...

author keywords: Escherichia coli; Incontinence; Proanthocyanidins; Spinal cord injury
MeSH headings : Administration, Oral; Animals; Anti-Infective Agents / administration & dosage; Anti-Infective Agents / therapeutic use; Bacteriuria / complications; Bacteriuria / drug therapy; Bacteriuria / urine; Bacteriuria / veterinary; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / veterinary; Male; Plant Extracts / administration & dosage; Plant Extracts / therapeutic use; Prospective Studies; Single-Blind Method; Thoracic Vertebrae; Treatment Outcome; Urinary Tract Infections / complications; Urinary Tract Infections / drug therapy; Urinary Tract Infections / urine; Urinary Tract Infections / veterinary; Vaccinium macrocarpon
TL;DR: This clinical trial did not show a benefit of oral cranberry extract but had low power, but a possible association between urine AAA and lower risk of E. coli bacteriuria was identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Plasma and serum concentrations of cytarabine administered via continuous intravenous infusion to dogs with meningoencephalomyelitis of unknown etiology

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 40(4), 411–414.

By: P. Early n, K. Crook, L. Williams *, E. Davis *, K. Munana n , M. Papich n , K. Messenger n

Contributors: P. Early n, K. Crook, L. Williams *, E. Davis *, K. Muñana n , M. Papich n , K. Messenger n

MeSH headings : Animals; Area Under Curve; Cytarabine / administration & dosage; Cytarabine / pharmacokinetics; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Encephalomyelitis / blood; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Infusions, Intravenous / veterinary
TL;DR: The steady-state achieved with cytarabine CRI produces a consistent and prolonged exposure in plasma and serum, which is likely to produce equilibrium between blood and the central nervous system in dogs with a clinical diagnosis of MUE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Practice patterns in the management of acute intervertebral disc herniation in dogs

JOURNAL OF SMALL ANIMAL PRACTICE, 57(8), 409–415.

By: S. Moore *, P. Early n & B. Hettlich *

MeSH headings : Animals; Canada; Diskectomy / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dogs; Female; Humans; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Lumbar Vertebrae / diagnostic imaging; Lumbar Vertebrae / surgery; Male; Practice Patterns, Physicians' / statistics & numerical data; Radiography / veterinary; Surveys and Questionnaires; United States; Veterinary Medicine / statistics & numerical data
TL;DR: Understanding the common practices in the management of canine acute intervertebral disc herniation can provide a springboard for future discussions regarding the best practices in diagnosing and treating this disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Recovery of stepping and coordination in dogs following acute thoracolumbar intervertebral disc herniations

The Veterinary Journal, 213, 59–63.

By: C. Rousse n, N. Olby n , K. Williams n, T. Harris n, E. Griffith n, C. Mariani n , K. Muñana n , P. Early n

Contributors: C. Rousse n, N. Olby n , K. Williams n, T. Harris n, E. Griffith n, C. Mariani n , K. Muñana n , P. Early n

author keywords: Canine; Gait; Locomotion; Paralysis; Spinal cord injury
MeSH headings : Acute Disease; Animals; Dog Diseases / etiology; Dog Diseases / surgery; Dogs; Female; Forelimb / physiology; Hindlimb / physiology; Intervertebral Disc / pathology; Intervertebral Disc / surgery; Intervertebral Disc Displacement / etiology; Intervertebral Disc Displacement / surgery; Intervertebral Disc Displacement / veterinary; Male; Prospective Studies; Spinal Cord Injuries / etiology; Spinal Cord Injuries / surgery; Spinal Cord Injuries / veterinary; Walking
TL;DR: Recovery of coordination was incomplete in dogs that showed good recovery of stepping in the 6 weeks following surgical decompression of dogs with TL-IVDH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

A Placebo-Controlled, Prospective, Randomized Clinical Trial of Polyethylene Glycol and Methylprednisolone Sodium Succinate in Dogs with Intervertebral Disk Herniation

JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(1), 206–214.

By: N. Olby n , A. Muguet-Chanoit n, J. Lim n, M. Davidian n , C. Mariani n , A. Freeman*, S. Platt *, J. Humphrey n ...

Contributors: N. Olby n , A. Muguet-Chanoit n, J. Lim n, M. Davidian n , C. Mariani n , A. Freeman*, S. Platt *, J. Humphrey n ...

author keywords: Neuroprotection; Paraplegia; Secondary injury; Spinal cord injury
MeSH headings : Animals; Anti-Inflammatory Agents / administration & dosage; Anti-Inflammatory Agents / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Intervertebral Disc Displacement / drug therapy; Intervertebral Disc Displacement / veterinary; Male; Methylprednisolone Hemisuccinate / administration & dosage; Methylprednisolone Hemisuccinate / therapeutic use; Nociception / drug effects; Polyethylene Glycols / administration & dosage; Polyethylene Glycols / therapeutic use
TL;DR: This clinical trial did not show a benefit of either MPSS or PEG in the treatment of acute, severe thoracolumbar IVDH when used as adjunctive medical treatment administered to dogs presenting within 24 hours of onset of paralysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

In vitro biomechanical evaluation of internal fixation techniques on the canine lumbosacral junction

PeerJ, 3.

By: P. Early, P. Mente, S. Dillard & S. Roe 

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Long-Term Effect of Cervical Distraction and Stabilization on Neurological Status and Imaging Findings in Giant Breed Dogs With Cervical Stenotic Myelopathy

Veterinary Surgery, 42(6), 701–709.

By: M. Lewis n, N. Olby n , N. Sharp & P. Early n

MeSH headings : Animals; Body Size; Cervical Vertebrae / pathology; Cervical Vertebrae / surgery; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Female; Male; Retrospective Studies; Spinal Cord Compression / complications; Spinal Cord Compression / surgery; Spinal Cord Compression / veterinary; Spinal Stenosis / pathology; Spinal Stenosis / surgery; Spinal Stenosis / veterinary; Tomography, X-Ray Computed
TL;DR: Distraction and stabilization with PMMA plugs and bone grafts is a safe surgical option for giant breed dogs with CSM with a single site of lateral or dorsolateral compression and long-term recurrence was common among dogs with multiple sites of compression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of Levetiracetam as Adjunctive Treatment for Refractory Canine Epilepsy: A Randomized, Placebo-Controlled, Crossover Trial

JOURNAL OF VETERINARY INTERNAL MEDICINE, 26(2), 341–348.

By: K. Munana n , W. Thomas*, K. Inzana*, J. Nettifee-Osborne n, K. McLucas*, N. Olby n , C. Mariani n , P. Early n

Contributors: K. Muñana n , W. Thomas*, K. Inzana*, J. Nettifee-Osborne n, K. McLucas*, N. Olby n , C. Mariani n , P. Early n

author keywords: Clinical pharmacology; CNS disorders; Dog; Epilepsy; Neurology; Seizures
MeSH headings : Animals; Anticonvulsants / administration & dosage; Anticonvulsants / adverse effects; Anticonvulsants / blood; Cross-Over Studies; Dog Diseases / blood; Dog Diseases / drug therapy; Dogs; Double-Blind Method; Epilepsy / blood; Epilepsy / drug therapy; Epilepsy / veterinary; Female; Levetiracetam; Male; Piracetam / administration & dosage; Piracetam / adverse effects; Piracetam / analogs & derivatives; Piracetam / blood; Quality of Life; Seizures / blood; Seizures / drug therapy; Seizures / veterinary; Statistics, Nonparametric
TL;DR: Adjunctive treatment with LEV appears safe in epileptic dogs and effectiveness over placebo was not demonstrated, although the power of the study was limited. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

In vitro biomechanical comparison of the flexion/extension mobility of the canine lumbosacral junction before and after dorsal laminectomy and partial discectomy

VETERINARY JOURNAL, 196(3), 533–535.

By: P. Early n, P. Mente n, S. Dillard* & S. Roe n 

author keywords: Lumbosacral; Biomechanics; Dog; Intervertebral disc; Laminectomy
MeSH headings : Animals; Biomechanical Phenomena; Cadaver; Diskectomy / veterinary; Dogs; Laminectomy / veterinary; Lumbosacral Region
TL;DR: It is demonstrated that dorsal laminectomy and partial discectomy at the lumbosacral junction does lead to significant spinal instability and dogs with lumbOSacral subluxation, active dogs with little radiographic degenerative changes and working dogs could benefit from lumbsacral stabilization. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

The pharmacokinetics of cytarabine in dogs when administered via subcutaneous and continuous intravenous infusion routes

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 36(4), 408–411.

By: K. Crook n, P. Early n, K. Messenger n, K. Munana n , R. Gallagher  n & M. Papich n 

Contributors: K. Crook n, P. Early n, K. Messenger n, K. Muñana n , R. Gallagher  n & M. Papich n 

MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Area Under Curve; Cross-Over Studies; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Dogs / blood; Dogs / metabolism; Half-Life; Infusions, Intravenous / veterinary; Injections, Subcutaneous / veterinary
TL;DR: The steady state achieved with the cyTarabine CRI may produce a more prolonged exposure of cytarabine at cytotoxic levels in plasma compared to the concentrations after SC administration, as these are two routes of administration commonly employed in the treatment of meningitis of unknown etiology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

The Cutaneous Trunci Muscle Reflex: A Predictor of Recovery in Dogs with Acute Thoracolumbar Myelopathies Caused by Intervertebral Disc Extrusions

Veterinary Surgery, 41(2), 200–206.

By: A. Muguet-Chanoit n, N. Olby n , J. Lim n, R. Gallagher, Z. Niman*, S. Dillard*, J. Campbell n, P. Early n ...

Contributors: A. Muguet-Chanoit n, N. Olby n , J. Lim n, R. Gallagher, Z. Niman*, S. Dillard*, J. Campbell n, P. Early n ...

MeSH headings : Animals; Cohort Studies; Dog Diseases / physiopathology; Dogs; Female; Intervertebral Disc Degeneration / veterinary; Intervertebral Disc Displacement / veterinary; Male; Muscle, Skeletal / physiology; Muscular Diseases / physiopathology; Muscular Diseases / veterinary; Predictive Value of Tests; Reflex / physiology
TL;DR: Postoperative changes of the caudal border of the CTM reflex are an early indicator of outcome in dogs with severe acute IVDE and cranial movement of theCTM reflex is significantly associated with improvement, but not associated with a long-term successful outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2004 journal article

Lumbosacral disc disease in a cat

Veterinary and Comparative Orthopaedics and Traumatology, 17(2), 104–106.

By: G. Jaeger*, P. Early*, K. Munana*  & E. Hardie*

TL;DR: An eight-year-old male castrated domestic shorthair admitted with a two-day history of acute back pain, flaccid tail, and urinary and faecal incontinence is the first case report of a cat with documented lumbosacral disc disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

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