@misc{need_attix_mcevoy_cirulli_linney_hunt_ge_heinzen_maia_shianna_et al._2009, title={A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB}, volume={18}, number={23}, journal={Human Molecular Genetics}, author={Need, A. C. and Attix, D. K. and McEvoy, J. M. and Cirulli, E. T. and Linney, K. L. and Hunt, P. and Ge, D. L. and Heinzen, E. L. and Maia, J. M. and Shianna, K. V. and et al.}, year={2009}, pages={4650–4661} }
 @article{goering_hunt_heighington_busick_pennings_hermisson_kumar_gibson_2009, title={Association of orthodenticle with Natural Variation for Early Embryonic Patterning in Drosophila melanogaster}, volume={312B}, ISSN={["1552-5015"]}, DOI={10.1002/jez.b.21299}, abstractNote={AbstractAlthough it is well established that cis‐acting regulatory variation contributes to morphological evolution between species, few concrete examples of polymorphism affecting developmental patterning within species have been demonstrated. Early embryogenesis in Drosophila is initiated by a gradient of Bicoid morphogen activity that results in differential expression of multiple target genes. In a screen for genetic variation affecting this process, we surveyed 96 wild‐type lines of Drosophila melanogaster for polymorphisms in binding sites within 16 Bicoid cis‐regulatory response elements. One common polymorphism in the orthodenticle (otd) early head enhancer is associated with a complex series of indels/substitutions that define two distinct haplotypes. The middle region of this enhancer exhibits an unusual pattern of nucleotide diversity that does not easily fit into standard models of selection and demography. Population Gene Expression Maps, generated by extracting binary expression profiles from normalized embryo images, revealed a ventral reduction of otd transcript abundance in one of the haplotypes that was recapitulated in expression of transgenic constructs containing the two alleles. We thus demonstrate that even a process as robust as early developmental patterning is affected by standing genetic variation, intriguingly involving otd, whose morphogenetic function bicoid is thought to have displaced during dipteran evolution. J. Exp. Zool. (Mol. Dev. Evol.) 312B:841–854, 2009. © 2009 Wiley‐Liss, Inc.}, number={8}, journal={JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION}, author={Goering, Lisa M. and Hunt, Priscilla K. and Heighington, Cassandra and Busick, Christopher and Pennings, Pleuni S. and Hermisson, Joachim and Kumar, Sudhir and Gibson, Greg}, year={2009}, month={Dec}, pages={841–854} }
 @article{passador-gurgel_hsieh_hunt_deighton_gibson_2007, title={Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster}, volume={39}, ISSN={["1061-4036"]}, DOI={10.1038/ng1944}, abstractNote={Although most genetic association studies are performed with the intention of detecting nucleotide polymorphisms that are correlated with a complex trait, transcript abundance should also be expected to associate with diseases or phenotypes. We performed a scan for such quantitative trait transcripts in adult female heads of the fruit fly (Drosophila melanogaster) that might explain variation for nicotine resistance. The strongest association was seen for abundance of ornithine aminotransferase transcripts, implicating detoxification and neurotransmitter biosynthesis as mediators of the quantitative response to the drug. Subsequently, genetic analysis and metabolite profiling confirmed a complex role for ornithine and GABA levels in modification of survival time upon chronic nicotine exposure. Differences between populations from North Carolina and California suggest that the resistance mechanism may be an evolved response to environmental exposure.}, number={2}, journal={NATURE GENETICS}, author={Passador-Gurgel, Gisele and Hsieh, Wen-Ping and Hunt, Priscilla and Deighton, Nigel and Gibson, Greg}, year={2007}, month={Feb}, pages={264–268} }