Philip L. Sannes

Works (34)

Updated: April 4th, 2024 17:59

2017 article

Hyaluronan: Local Climate Change in Asthma?

Sannes, P. L. (2017, December). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 57, pp. 635–636.

By: P. Sannes n

MeSH headings : Animals; Asthma / metabolism; Asthma / pathology; Asthma / physiopathology; Cell Movement; Cellular Microenvironment; Extracellular Matrix / metabolism; Extracellular Matrix / pathology; Humans; Hyaluronic Acid / metabolism; Lung / metabolism; Lung / pathology
TL;DR: It is hypothesized that peribronchiolar accumulation of HA contributes to airway inflammation, remodeling, and hyperresponsiveness in asthma, and this conceptually changed how ECMs fit into the context of the biological activities of a tissue and/or organ, and codified them as true biological response modifiers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Expression of WNT5A in Idiopathic Pulmonary Fibrosis and Its Control by TGF-β and WNT7B in Human Lung Fibroblasts

Journal of Histochemistry & Cytochemistry, 64(2), 99–111.

By: D. Newman n, W. Sills n, K. Hanrahan n, A. Ziegler n , K. Tidd n, E. Cook n, P. Sannes n

MeSH headings : Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / pathology; Gene Expression Regulation; Gene Silencing; Humans; Idiopathic Pulmonary Fibrosis / genetics; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Lung / metabolism; Lung / pathology; Myocytes, Smooth Muscle / metabolism; Myofibroblasts / metabolism; Myofibroblasts / pathology; Proto-Oncogene Proteins / analysis; Proto-Oncogene Proteins / genetics; Proto-Oncogene Proteins / metabolism; Transforming Growth Factor beta / analysis; Transforming Growth Factor beta / genetics; Transforming Growth Factor beta / metabolism; Up-Regulation; Wnt Proteins / analysis; Wnt Proteins / genetics; Wnt Proteins / metabolism; Wnt-5a Protein
TL;DR: A wide distribution of Wnt5A expression in cells of the IPF lung is demonstrated and it is revealed that it is significantly increased by Wnt7B and TGF-β1, which, in combination, could represent key signaling pathways that modulate the pathogenesis of IPF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2015 journal article

Heparin and LPS-induced COX-2 expression in airway cells: a link between its anti-inflammatory effects and GAG sulfation

EXPERIMENTAL LUNG RESEARCH, 41(9), 499–513.

By: N. Yi n, D. Newman n, H. Zhang n, H. Johansson n & P. Sannes n

author keywords: COX-2; heparin; LPS; lung; sulfation
MeSH headings : Anti-Inflammatory Agents, Non-Steroidal / chemistry; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Cell Line; Cyclooxygenase 2 / genetics; Cyclooxygenase 2 / metabolism; Gene Expression / drug effects; Glycosaminoglycans / chemistry; Glycosaminoglycans / metabolism; Heparin / chemistry; Heparin / pharmacology; Humans; Interleukin-8 / genetics; Interleukin-8 / metabolism; Lipopolysaccharides / toxicity; MAP Kinase Signaling System / drug effects; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism
TL;DR: Heparin's anti-inflammatory effects result from its nonspecific suppression of signaling and gene expression and are determined by its sulfation, which may reflect the moderating role of GAG sulfation in lung injury and health. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging

AGING CELL, 14(5), 764–773.

By: N. Muthusamy n, L. Sommerville n, A. Moeser n, D. Stumpo *, P. Sannes n, K. Adler n, P. Blackshear *, J. Weimer *, H. Ghashghaei  n

author keywords: aging; barrier function; Clca3; cerebral cortex; ependymal cells; lipid droplets; mucin; oxidative stress
MeSH headings : Aging / metabolism; Animals; Ependyma / cytology; Ependyma / metabolism; Homeostasis; Intracellular Signaling Peptides and Proteins / deficiency; Intracellular Signaling Peptides and Proteins / metabolism; Lipid Metabolism; Membrane Proteins / deficiency; Membrane Proteins / metabolism; Mice; Mucins / metabolism; Myristoylated Alanine-Rich C Kinase Substrate; Oxidative Stress; Prosencephalon / metabolism
TL;DR: It is demonstrated that metabolic and barrier functions in ECs decline significantly during aging in mice, and this work constitutes a conceptually new paradigm in the potential role of ECs in the initiation of various conditions and diseases in the aging brain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Whole-Genome Analysis of Temporal Gene Expression during Early Transdifferentiation of Human Lung Alveolar Epithelial Type 2 Cells In Vitro

PLOS ONE, 9(4).

By: H. Johansson  n, D. Newman n & P. Sannes n

MeSH headings : Alveolar Epithelial Cells / cytology; Alveolar Epithelial Cells / metabolism; Caveolin 1 / genetics; Caveolin 1 / metabolism; Cell Transdifferentiation / genetics; Cells, Cultured; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; Humans; Protein Transport; Reproducibility of Results; Time Factors; Transcriptome
TL;DR: The utility of genome-wide analysis to identify relevant, novel cell type-specific signatures of early ECM-regulated alveolar epithelial transdifferentiation processes in vitro is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Expression of Fibroblast Growth Factor 9 in Normal Human Lung and Idiopathic Pulmonary Fibrosis

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 61(9), 671–679.

By: E. Coffey n, D. Newman n & P. Sannes n

author keywords: smooth muscle cells; myofibroblast; metaplastic epithelium
MeSH headings : Adult; Cells, Cultured; Fibroblast Growth Factor 9 / analysis; Fibroblast Growth Factor 9 / metabolism; Humans; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Immunohistochemistry; Lung / metabolism; Lung / pathology; Lung / ultrastructure; Myocytes, Smooth Muscle / metabolism; Myocytes, Smooth Muscle / pathology; Myocytes, Smooth Muscle / ultrastructure; Myofibroblasts / metabolism; Myofibroblasts / pathology; Myofibroblasts / ultrastructure
TL;DR: Lungs of IPF patients expressed FGF9 in a population of myofibroblasts within fibroblastic foci, hypertrophic and hyperplastic epithelium of airways and alveoli, and smooth muscle cells surrounding vessels embedded in thickened interstitium, demonstrating a potentially strong candidate for contributing to the progression of IPf. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 journal article

HSULF-1 inhibits ERK and AKT signaling and decreases cell viability in vitro in human lung epithelial cells

Respiratory Research, 13(1), 69.

By: H. Zhang  n, D. Newman n & P. Sannes n

author keywords: Human endosulfatase 1; Heparan sulfate proteoglycans
MeSH headings : Apoptosis / genetics; Cell Line, Tumor; Cell Survival; Epithelial Cells / enzymology; Humans; In Situ Nick-End Labeling; Lung / enzymology; Lung Neoplasms / enzymology; MAP Kinase Signaling System / genetics; Proto-Oncogene Proteins c-akt / metabolism; Real-Time Polymerase Chain Reaction; Signal Transduction; Sulfotransferases / metabolism
TL;DR: It is indicated that HSULF-1 is expressed at lower levels in H292 lung cancer cells than in normal human alveolar cells and that its over-expression reduced cell viability in H 292 cells by inducing apoptotic pathways, at least in part by inhibiting ERK/Akt signaling. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: July 20, 2019

2012 journal article

Over-expression of human endosulfatase-1 exacerbates cadmium-induced injury to transformed human lung cells in vitro

TOXICOLOGY AND APPLIED PHARMACOLOGY, 265(1), 27–42.

By: H. Zhang n, D. Newman n, J. Bonner n  & P. Sannes n

author keywords: Cadmium; HSulf-1; Lung epithelial injury; 6-O-sulfate
MeSH headings : Adenoviridae / genetics; Apoptosis / drug effects; Blotting, Western; Cadmium / toxicity; Cell Count; Cell Line, Tumor; Cell Survival / drug effects; Cell Transformation, Neoplastic / drug effects; Coloring Agents; Down-Regulation / drug effects; Heparan Sulfate Proteoglycans / pharmacology; Humans; In Situ Nick-End Labeling; Lac Operon / genetics; Lung / pathology; Polymerase Chain Reaction; Respiratory Mucosa / pathology; Sulfotransferases / biosynthesis; Sulfotransferases / physiology; Tetrazolium Salts; Thiazoles; Transduction, Genetic; Up-Regulation / drug effects
TL;DR: The finding that HSulf-1 sensitizes these cancer cells and intensifies the injury induced by cadmium suggests that 6-O-sulfate groups on HSPGs may play important roles in protection against certain environmental toxicants, such as heavy metals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis

Respiratory Research, 13(1), 62.

By: T. Meuten n, A. Hickey n, K. Franklin n, B. Grossi n, J. Tobias  n, D. Newman n, S. Jennings n, M. Correa n, P. Sannes n

author keywords: Myofibroblasts; Alveolar epithelium; Interstitial lung disease
MeSH headings : Aged; Aged, 80 and over; Basement Membrane / pathology; Female; Fibroblasts / pathology; Humans; Idiopathic Pulmonary Fibrosis / metabolism; Idiopathic Pulmonary Fibrosis / pathology; Macrophages / pathology; Male; Middle Aged; Muscle, Smooth / pathology; Respiratory Mucosa / pathology; Respiratory System / blood supply; Respiratory System / pathology; Severity of Illness Index; Wnt Proteins / analysis; Wnt Proteins / metabolism
TL;DR: Tissue samples from the Lung Tissue Research Consortium of 39 patients diagnosed with mild to severe IPF/usual interstitial pneumonia and 19 normal patients were examined for the immunolocalization of Wnt7B, demonstrating Wnt 7B to be expressed at high concentrations in regions of active hyperplasia, metaplasia and fibrotic change in IPF patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Heterotaxin: A TGF-beta Signaling Inhibitor Identified in a Multi-Phenotype Profiling Screen in Xenopus Embryos

CHEMISTRY & BIOLOGY, 18(2), 252–263.

By: M. Dush n, A. McIver n, M. Parr n, D. Young n, J. Fisher n, D. Newman n, P. Sannes n, M. Hauck n, A. Deiters n, N. Nascone-Yoder n 

MeSH headings : Animals; Cell Line; Drug Evaluation, Preclinical; Embryo, Nonmammalian / abnormalities; Embryo, Nonmammalian / cytology; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / metabolism; Humans; Intracellular Space / drug effects; Intracellular Space / metabolism; Neovascularization, Physiologic / drug effects; Phenotype; Pyridines / chemistry; Pyridines / pharmacology; Signal Transduction / drug effects; Stereoisomerism; Structure-Activity Relationship; Transforming Growth Factor beta / metabolism; Xenopus laevis
TL;DR: A small molecule screen for left-right asymmetry phenotypes in Xenopus embryos is performed and a pyridine analog, heterotaxin, is discovered, which disrupts both cardiovascular and digestive organ laterality and inhibits TGF-β-dependent left- right asymmetric gene expression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

Temporal Changes in Expression of FoxA1 and Wnt7A in Isolated Adult Human Alveolar Epithelial Cells Enhanced by Heparin

ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY, 293(6), 938–946.

By: K. Apparao n, D. Newman n, H. Zhang n, J. Khosla n, S. Randell * & P. Sannes n

author keywords: beta-catenin; differentiation; heparin; sulfated extracellular matrices
MeSH headings : Adult; Anticoagulants / physiology; Biomarkers / metabolism; Cell Differentiation / drug effects; Cell Differentiation / physiology; Cell Line; Cell Separation; Cells, Cultured; Heparin / physiology; Hepatocyte Nuclear Factor 3-alpha / biosynthesis; Hepatocyte Nuclear Factor 3-alpha / genetics; Humans; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Respiratory Mucosa / cytology; Respiratory Mucosa / drug effects; Respiratory Mucosa / metabolism; Time Factors; Wnt Proteins / biosynthesis; Wnt Proteins / genetics; beta Catenin / biosynthesis; beta Catenin / genetics
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Alterations in cytoskeletal and immune function-related proteome profiles in whole rat lung following intratracheal instillation of heparin

RESPIRATORY RESEARCH, 8.

By: A. Gabr n, M. Reed*, D. Newman n, J. Pohl*, J. Khosla n & P. Sannes n

MeSH headings : Administration, Inhalation; Animals; Anticoagulants / administration & dosage; Cytoskeleton / drug effects; Cytoskeleton / ultrastructure; Gene Expression Regulation / drug effects; Heparin / administration & dosage; Lung / drug effects; Lung / immunology; Lung / ultrastructure; Proteome / drug effects; Proteomics / methods; Rats; Rats, Inbred F344; Reference Values
TL;DR: It is demonstrated that whole lung heparin treatment results in significant up-regulation of selected groups of proteins, primarily those related to cytoskeletal reorganization and immune function, which may prove to be relevant biomarkers useful in analysis of lung exposures/treatments as well as in system biology studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Fibroblast growth factor-binding protein and N-deacetylase/N-sulfotransferase-1 expression in type II cells is modulated by heparin and extracellular matrix

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 293(5), L1314–L1320.

By: D. Newman n, E. Walsh*, K. Apparao & P. Sannes*

author keywords: coculture; alveolus; sulfation
MeSH headings : Animals; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cells, Cultured; Extracellular Matrix / metabolism; Fibroblasts / cytology; Fibroblasts / metabolism; Heparin / pharmacology; Intercellular Signaling Peptides and Proteins; Lung / cytology; Lung / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Sulfotransferases / genetics; Sulfotransferases / metabolism
TL;DR: Results demonstrate a potentially important modulatory influence of sulfated ECMs and fibroblasts on FGF-BP and NDST-1 at the gene expression level and demonstrate that performed ECM appears to supply factors that modify subsequent treatment effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Heparin and fibroblast growth factors affect surfactant protein gene expression in type II cells

American Journal of Respiratory Cell and Molecular Biology, 35(5), 611–618.

By: K. Leiner, D. Newman, C. Li, E. Walsh, J. Khosla & P. Sannes

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

Heparin affects signaling pathways stimulated by fibroblast growth factor-1 and-2 in type II cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 287(1), L191–L200.

By: D. Newman n, C. Li n, R. Simmons n, J. Khosla n & P. Sannes n

author keywords: extracellular matrix; basement membrane; receptor tyrosine kinase phosphorylation; ERK pathway; fibroblast growth factor signaling
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Heparin / administration & dosage; Heparin / pharmacology; Mitogen-Activated Protein Kinases / metabolism; Phosphorylation / drug effects; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins / metabolism; Proto-Oncogene Proteins c-akt; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / physiology; Rats; Rats, Inbred Strains; Signal Transduction / drug effects; Sulfates / metabolism; Thymidine / metabolism; Time Factors
TL;DR: The data suggest that heparin's known capacity to alter DNA synthesis and, possibly, other biological end points is realized via cross talk between multiple signaling pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Atypical development of the tracheal basement membrane zone of infant rhesus monkeys exposed to ozone and allergen

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 285(4), L931–L939.

By: M. Evans *, M. Fanucchi*, G. Baker *, L. Van Winkle *, L. Pantle*, S. Nishio*, E. Schelegle *, L. Gershwin * ...

author keywords: perlecan; fibroblast growth factor-2; fibroblast growth factor; receptor-1; syndecan-4; epithelial-mesenchymal trophic unit
MeSH headings : Allergens / pharmacology; Animals; Animals, Newborn / growth & development; Basement Membrane / anatomy & histology; Basement Membrane / drug effects; Basement Membrane / growth & development; Basement Membrane / metabolism; Collagen Type I / metabolism; Drug Combinations; Fibroblast Growth Factor 2 / metabolism; Heparan Sulfate Proteoglycans / metabolism; Immunohistochemistry; In Vitro Techniques; Macaca mulatta; Membrane Glycoproteins / metabolism; Ozone / pharmacology; Proteoglycans / metabolism; Pyroglyphidae / immunology; Receptor Protein-Tyrosine Kinases / metabolism; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / metabolism; Syndecan-4; Trachea / anatomy & histology; Trachea / drug effects; Trachea / growth & development; Trachea / metabolism
TL;DR: It is concluded that ozone and HDMA plus ozone effected incorporation of perlecan into the BMZ, resulting in atypical development of theBMZ, which may be associated with the developmental problems of lungs associated with exposure to ozone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 article

Modulation of fibroblast growth factor expression and signal transduction in type II cells

Li, C. M., Newman, D., Cesta, M., Tompkins, L., Khosla, J., & Sannes, P. L. (2003, March). CHEST, Vol. 123, pp. 429S–429S.

By: C. Li n, D. Newman n, M. Cesta n, L. Tompkins n, J. Khosla n & P. Sannes n

MeSH headings : Antigenic Modulation / genetics; Antigenic Modulation / immunology; Asthma / genetics; Asthma / immunology; Epithelial Cells / immunology; Fibroblast Growth Factors / genetics; Fibroblast Growth Factors / immunology; Gene Expression / genetics; Gene Expression / immunology; Humans; In Vitro Techniques; Signal Transduction / genetics; Signal Transduction / immunology
TL;DR: The data suggests that airway fibroblasts from severe asthmatics may be of a synthetic phenotype, with altered capabilities in collagen production, as compared to those from patients with mild-to-moderate asthma and normal control subjects, and this may be driven by an increased expression of PDGFR. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Effect of growth factor-fibronectin matrix interaction on rat type II cell adhesion and DNA synthesis

EXPERIMENTAL LUNG RESEARCH, 28(2), 69–84.

By: I. Pagan n, J. Khosla n, C. Li n & P. Sannes n

author keywords: alveolar repair; beta 1integrin; cell-substratum interaction; cytoskeleton; fibroblast growth factors; fibronectin; type II cells
MeSH headings : Actins / metabolism; Animals; Blood Proteins / pharmacology; Cell Adhesion / drug effects; Cell Division / drug effects; Cell Size / drug effects; Cells, Cultured; Cytoskeletal Proteins / metabolism; DNA / biosynthesis; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / pharmacology; Fibronectins / pharmacology; Integrin beta1 / metabolism; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Respiratory Mucosa / cytology; Respiratory Mucosa / metabolism
TL;DR: Together FGF-1 and fibronectin appear to promote adhesion, cytoskeletal organization, and in creased DNA synthesis, andin this way influence cell-substratum interactions and signaling during alveolar repair. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Fibroblast growth factor-2 during postnatal development of the tracheal basement membrane zone

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 283(6), L1263–L1270.

By: M. Evans  n, M. Fanucchi n, L. Van Winkle  n, G. Baker  n, A. Murphy n, S. Nishio n, P. Sannes n, C. Plopper n

author keywords: basal cell; perlecan; fibroblast growth factor receptor-1; rhesus monkey
MeSH headings : Aging / metabolism; Animals; Animals, Newborn / growth & development; Basement Membrane / metabolism; Collagen / metabolism; Fibroblast Growth Factor 2 / metabolism; Heparan Sulfate Proteoglycans / metabolism; Immunohistochemistry; Macaca mulatta; Male; Receptor Protein-Tyrosine Kinases / metabolism; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / metabolism; Tissue Distribution; Trachea / anatomy & histology; Trachea / cytology; Trachea / metabolism
TL;DR: The data indicate that development of the BMZ is a postnatal event in the rhesus monkey that involves FGF-2 and FGFR-1, and that more dynamic, functional components of the epithelial-mesenchymal trophic unit are detected in the developing BMZ. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Heparin inhibits DNA synthesis and gene expression in alveolar type II cells

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 27(3), 345–352.

By: C. Li n, D. Newman n, J. Khosla n & P. Sannes n

MeSH headings : Animals; Cell Division / drug effects; Cells, Cultured; DNA / biosynthesis; DNA / drug effects; Extracellular Matrix / drug effects; Extracellular Matrix / metabolism; Fibroblast Growth Factor 1 / genetics; Fibroblast Growth Factor 1 / metabolism; Fibroblast Growth Factor 1 / pharmacology; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Heparin / pharmacology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / drug effects; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor / drug effects; Receptors, Fibroblast Growth Factor / genetics; Thymidine / metabolism
TL;DR: It is demonstrated that sulfated molecules in the ABM may play important regulatory role(s) in selected type II cell activities during normal cell homeostasis, turnover, and repair after lung injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Pre- and postnatal lung development, maturation, and plasticity: Detection of chondroitin sulfates and decorin in developing fetal and neonatal rat lung

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 282(3), L484–L490.

By: Y. Wang n, K. Sakamoto n , J. Khosla n & P. Sannes n

Contributors: Y. Wang n, K. Sakamoto n , J. Khosla n & P. Sannes n

author keywords: extracellular matrix; basal laminae; growth factors; mesenchyme
MeSH headings : Aging / metabolism; Animals; Animals, Newborn / growth & development; Animals, Newborn / metabolism; Chondroitin Sulfates / metabolism; Decorin; Embryonic and Fetal Development; Extracellular Matrix Proteins; Fetus / physiology; Immunologic Techniques; Lung / embryology; Lung / growth & development; Lung / metabolism; Proteoglycans / metabolism; Rats; Rats, Inbred F344; Staining and Labeling
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 article

Transforming growth factor-beta(1) modifies fibroblast growth factor-2 production in type II cells

Li, C. M., Khosla, J., Hoyle, P., & Sannes, P. L. (2001, July). CHEST, Vol. 120, pp. 60S–61S.

By: C. Li n, J. Khosla n, P. Hoyle n & P. Sannes n

author keywords: alveolar epithelium; extracellular matrix; growth factors
MeSH headings : Animals; Fibroblast Growth Factor 2 / biosynthesis; Pulmonary Alveoli / metabolism; Rats; Rats, Inbred F344; Transforming Growth Factor beta / physiology; Transforming Growth Factor beta1
TL;DR: Important regulatory links between FGF-2, sulfated ECMs, and both TGF-β 1 and FGF, which could contribute to the modulation of normal cell turnover, development, and repair processes attendant to fibrosis in the lung are demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Vanadium stimulates human bronchial epithelial cells to produce heparin-binding epidermal growth factor-like growth factor - A mitogen for lung fibroblasts

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 24(2), 123–131.

By: L. Zhang  n, A. Rice n, K. Adler n, P. Sannes n, L. Martin n, W. Gladwell n, J. Koo n, T. Gray n, J. Bonner  n

MeSH headings : Blotting, Northern; Blotting, Western; Bronchi / drug effects; Bronchi / metabolism; Cells, Cultured; DNA Primers / chemistry; Enzyme Inhibitors / pharmacology; Enzyme-Linked Immunosorbent Assay; Epidermal Growth Factor / biosynthesis; Epidermal Growth Factor / genetics; Epithelial Cells / drug effects; Epithelial Cells / metabolism; ErbB Receptors / antagonists & inhibitors; Fibroblast Growth Factor 2 / metabolism; Fibroblasts / drug effects; Heparin-binding EGF-like Growth Factor; Humans; Immunoenzyme Techniques; Intercellular Signaling Peptides and Proteins; Lung / physiology; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Mitogen-Activated Protein Kinases / antagonists & inhibitors; Protein Tyrosine Phosphatases / antagonists & inhibitors; RNA, Messenger / metabolism; Receptors, Platelet-Derived Growth Factor / antagonists & inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Vanadium / pharmacology; p38 Mitogen-Activated Protein Kinases
TL;DR: It is reported that conditioned medium from normal human bronchial epithelial cells (NHBECs) contains mitogenic activity for human lung fibroblasts that is blocked by the epidermal growth factor receptor (EGF-R) tyrosine kinase inhibitor AG1478 and by neutralizing antibodies raised against heparin-binding epidermis growth factor-like growth factor (HB-EGF). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 article

Induction of heparin-binding epidermal growth factor (HB-EGF) mRNA in normal human bronchial epithelial cells by metal-induced oxidative stress.

American Journal of Respiratory and Critical Care Medicine, Vol. 161, p. A149.

By: J. Bonner , L. Zhang, P. Sannes, L. Martin, W. Gladwell, J. Koo, T. Gray, K. Adler

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

TGF-beta 1 and fibroblast growth factor-1 modify fibroblast growth factor-2 production in type II cells

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 279(6), L1038–L1046.

By: C. Li n, J. Khosla n, I. Pagan n, P. Hoyle n & P. Sannes n

author keywords: basic fibroblast growth factor; acidic fibroblast growth factor; alveolar epithelium; alveolar injury; pulmonary fibrosis; transforming growth factor
MeSH headings : Animals; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblast Growth Factor 1; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / pharmacology; Gene Expression / drug effects; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Fibrosis / metabolism; RNA, Messenger / analysis; Rats; Rats, Inbred F344; Receptor Protein-Tyrosine Kinases / genetics; Receptor, Fibroblast Growth Factor, Type 1; Receptors, Fibroblast Growth Factor / genetics; Specific Pathogen-Free Organisms; Transforming Growth Factor beta / pharmacology
TL;DR: Fibroblast growth factor (FGF)-2, which stimulates DNA synthesis by type II cells in the lung, has been shown to be regulated by transforming growth factors (TGF)-β1, an important inflammatory cytokine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Three-dimensional organization of the lamina reticularis in the rat tracheal basement membrane zone

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 22(4), 393–397.

By: M. Evans  n, L. Van Winkle  n, M. Fanucchi n, E. Toskala n, E. Luck n, P. Sannes n, C. Plopper n

MeSH headings : Animals; Basement Membrane / ultrastructure; Collagen / ultrastructure; Elastin / ultrastructure; Epithelial Cells / ultrastructure; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Rats / anatomy & histology; Rats, Sprague-Dawley; Trachea / ultrastructure
TL;DR: The present studies demonstrate that the structural proteins of the lamina reticularis in the rat trachea are arranged as fibers in a highly organized manner. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 article

Normal human bronchial epithelial cells produce heparin-binding epidermal growth factor (HB-EGF), a mitogen for human lung fibroblasts in vitro.

American Journal of Respiratory and Critical Care Medicine, Vol. 159, p. A508.

By: L. Zhang, K. Adler, P. Sannes & J. Bonner 

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Sulfation of extracellular matrices modifies growth factor effects on type II cells on laminin substrata

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 275(4), L701–L708.

By: P. Sannes n, J. Khosla n, C. Li n & I. Pagan n

author keywords: sulfated proteoglycans; basement membrane; acidic fibroblast growth factor; basic fibroblast growth factor; keratinocyte growth factor
MeSH headings : Animals; Cell Adhesion / drug effects; Cell Division / drug effects; Cells, Cultured; Chondroitin / pharmacology; Chondroitin Sulfates / pharmacology; Chondroitin Sulfates / physiology; Extracellular Matrix / physiology; Fibroblast Growth Factor 1; Fibroblast Growth Factor 10; Fibroblast Growth Factor 2 / pharmacology; Fibroblast Growth Factor 7; Fibroblast Growth Factors; Growth Substances / pharmacology; Growth Substances / physiology; Heparin / pharmacology; Heparin / physiology; Heparitin Sulfate / pharmacology; Heparitin Sulfate / physiology; Laminin / pharmacology; Laminin / physiology; Pulmonary Alveoli / cytology; Pulmonary Alveoli / drug effects; Pulmonary Alveoli / physiology; Rats; Rats, Inbred F344
TL;DR: It is demonstrated that decreased levels of sulfate in ECM substrata act to upregulate responses to heparin-binding growth factors by alveolar epithelial cells on laminin substrata. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 article

Basement membranes and pulmonary development

EXPERIMENTAL LUNG RESEARCH, Vol. 23, pp. 101–108.

By: P. Sannes n & J. Wang  n

author keywords: basal lamina; basic fibroblast growth factor; chondroitin sulfate proteoglycan; extracellular matrix; immunohistochemistry
MeSH headings : Animals; Basement Membrane / chemistry; Basement Membrane / embryology; Basement Membrane / growth & development; Embryonic and Fetal Development; Extracellular Matrix / chemistry; Extracellular Matrix / physiology; Humans; Lung / chemistry; Lung / embryology; Lung / growth & development; Mesoderm / physiology
TL;DR: Basement membranes are specialized extracellular matrices which serve as complex interfaces between epithelia, peripheral nerves, or muscle cells and their surrounding tissue microenvironments and Basic fibroblast growth factor is an example of the latter, because it localizes with all BM components by immunostaining throughout development and reflects the multifactorial array of potential effectors in the complex processes of proliferation and differentiation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 journal article

Biosynthesis of sulfated extracellular matrices by alveolar type II cells increases with time in culture

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 273(4), L840–L847.

By: P. Sannes n, J. Khosla n & B. Peters n

author keywords: basement membrane; heparan sulfate proteoglycan; laminin; type IV collagen; entactin; fibronectin; type I pneumocytes; alveolar epithelium; sulfation; extracellular matrix
MeSH headings : Animals; Cells, Cultured; Cellular Senescence; Cysteine / metabolism; Extracellular Matrix / metabolism; Extracellular Matrix / ultrastructure; Extracellular Matrix Proteins / biosynthesis; Kinetics; Phenotype; Pulmonary Alveoli / cytology; Pulmonary Alveoli / metabolism; Pulmonary Alveoli / ultrastructure; Rats; Rats, Inbred F344; Sulfates / metabolism; Sulfur Radioisotopes; Time Factors
TL;DR: The data suggest that regulation of sulfation constitutes a potential mechanism by which type I and type II cells alter their environment in such a manner as to stabilize phenotype and modulate responses to growth factors. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1996 article

Airway epithelium: A primary source for growth factors related to development of fibrosis?

Proceedings of the 9th International Colloquium on Lung Fibrosis, Vol. 9, p. 29.

By: K. Adler, M. Menard & P. Sannes

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

Specific interactions with extracellular matrix may influence epithelial repair mechanisms in the pulmonary alveolus.

Chest, 99, 70S–71.

By: P. Sannes, B. Peters & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

1990 article

Interactions between extracellular matrix, airway and alveolar epithelium: alterations in fibrosis and possible pathogenetic significance.

Proceedings of the Sixth International Colloquium Pulmonary Fibrosis., Vol. 6, p. 39.

By: K. Adler, B. Peters, T. Krunkosky & P. Sannes

Source: NC State University Libraries
Added: August 6, 2018

1990 article

Specific interactions with extracellular matrix may influence epithelial repair mechanisms in the pulmonary alveolus.

Proceedings of the 30th Aspen Lung Conference., Vol. 30, p. 24.

By: P. Sannes, B. Peters & K. Adler

Source: NC State University Libraries
Added: August 6, 2018

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