Paul Schlosser

Works (13)

Updated: July 2nd, 2024 05:12

2024 article

Evaluating the impact of anatomical and physiological variability on human equivalent doses using PBPK models

Schacht, C. M., Meade, A. E., Bernstein, A. S., Prasad, B., Schlosser, P. M., Tran, H. T., & Kapraun, D. F. (2024, May 25). TOXICOLOGICAL SCIENCES, Vol. 5.

By: C. Schacht*, A. Meade*, A. Bernstein *, B. Prasad*, P. Schlosser*, H. Tran n , D. Kapraun*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2024

2009 journal article

A Multicompartment Liver-based Pharmacokinetic Model for Benzene and its Metabolites in Mice

BULLETIN OF MATHEMATICAL BIOLOGY, 72(3), 507–540.

By: C. Manning n, P. Schlosser* & H. Tran n 

author keywords: Benzene metabolism model; Ordinary differential equations; Existence and uniqueness; Inverse problems
MeSH headings : Animals; Benzene / pharmacokinetics; Cytochrome P-450 CYP2E1 / metabolism; Glutathione / metabolism; Liver / enzymology; Liver / metabolism; Mice; Models, Biological
TL;DR: This study shows that the multicompartment metabolism model does improve predictions over the previous model and that in vitro metabolic constants can be successfully extrapolated to predict in vivo data for benzene metabolism and dosimetry. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Sensory irritation response in rats: Modeling, analysis and validation

BULLETIN OF MATHEMATICAL BIOLOGY, 70(2), 555–588.

By: K. Yokley n, H. Tran n  & P. Schlosser*

author keywords: sensory response; PBPK; formaldehyde
MeSH headings : Animals; Computer Simulation; Dose-Response Relationship, Drug; Feedback, Physiological; Formaldehyde / toxicity; Gases / toxicity; Hypoventilation / etiology; Hypoventilation / physiopathology; Hypoventilation / veterinary; Inhalation Exposure; Irritants / toxicity; Models, Biological; Neuroepithelial Cells / drug effects; Neuroepithelial Cells / physiology; Pulmonary Ventilation / drug effects; Rats; Respiration / drug effects; Respiratory System / drug effects; Respiratory System / innervation; Respiratory System / physiopathology; Sensation / drug effects; Sensation / physiology; Trigeminal Nerve / drug effects; Trigeminal Nerve / physiopathology
TL;DR: A mathematical model is created to describe how the presence of irritants affects respiration in the rat and predicts the formaldehyde data well, and is thought to be a reasonable description of the physiological system of sensory irritation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

A delayed nonlinear PBPK model for genistein dosimetry in rats

BULLETIN OF MATHEMATICAL BIOLOGY, 69(1), 93–117.

By: M. Zagera, P. Schlosser* & H. Tran n 

author keywords: genistein; biliary excretion; pharmacokinetics; delay-differential equations
MeSH headings : Animals; Bile / metabolism; Biliary Tract / drug effects; Biliary Tract / metabolism; Genistein / pharmacokinetics; Genistein / pharmacology; Models, Biological; Nonlinear Dynamics; Rats
TL;DR: A physiologically based pharmacokinetic (PBPK) model that focuses on biliary excretion with the goal of accurately simulating the observed suppression of genistein is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Physiologically-based pharmacokinetic modeling of genistein in rats, part I: Model development

RISK ANALYSIS, 26(2), 483–500.

By: P. Schlosser*, S. Borghoff, N. Coldham, J. David & S. Ghosh* 

Contributors: P. Schlosser*, S. Borghoff, N. Coldham, J. David & S. Ghosh* 

author keywords: endocrine-active; genistein; PBPK; phytoestrogen; rat
MeSH headings : Animals; Blood Proteins / metabolism; Female; Genistein / administration & dosage; Genistein / blood; Genistein / pharmacokinetics; Humans; Male; Models, Biological; Phytoestrogens / administration & dosage; Phytoestrogens / blood; Phytoestrogens / pharmacokinetics; Protein Binding; Rats; Rats, Sprague-Dawley; Rats, Wistar; Risk; Tissue Distribution
TL;DR: A physiologically‐based pharmacokinetic (PBPK) model to quantify the internal, target‐tissue dosimetry of genistein in adult rats is developed and can serve as a template for other phytoestrogens and in the design of future experiments and research that can be used to fill data gaps and better estimate model parameters. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2003 journal article

Multiple stable periodic solutions in a model for hormonal control of the menstrual cycle

BULLETIN OF MATHEMATICAL BIOLOGY, 65(1), 157–173.

By: L. Clark, P. Schlosser & J. Selgrade

UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 review

A review of quantitative studies of benzene metabolism

[Review of ]. CRITICAL REVIEWS IN TOXICOLOGY, 31(3), 285–311.

By: M. Lovern*, C. Cole n & P. Schlosser*

MeSH headings : Animals; Benzene / administration & dosage; Benzene / metabolism; Benzene / pharmacokinetics; Enzyme Induction / drug effects; Female; Humans; In Vitro Techniques; Male; Microsomes / metabolism; Models, Theoretical
TL;DR: Results from both experimental and mathematical modeling research are considered, with particular emphasis on the last decade, and the factors that are likely to be most influential in the metabolism of benzene are discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Physiologically based pharmacokinetic modeling of benzene metabolism in mice through extrapolation from in vitro to in vivo

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A, 62(6), 439–465.

By: C. Cole n, H. Tran n  & P. Schlosser n

MeSH headings : Administration, Inhalation; Algorithms; Animals; Benzene / chemistry; Benzene / metabolism; Benzene / pharmacokinetics; Benzene Derivatives / chemistry; Benzene Derivatives / metabolism; Benzene Derivatives / pharmacokinetics; Chemical Phenomena; Chemistry, Physical; Mice; Models, Biological; Risk Assessment
TL;DR: In vitro metabolic constants for humans can be extrapolated to predict the dosimetry of benzene and its metabolites in humans to better estimate the risks of adverse effects from low-level benzene exposures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

A model of gonadotropin regulation during the menstrual cycle in women: Qualitative features

ENVIRONMENTAL HEALTH PERSPECTIVES, 108, 873–881.

By: P. Schlosser* & J. Selgrade*

author keywords: estradiol; follicle-stimulating hormone; luteinizing hormone; mathematical model; menstrual cycle; progesterone
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Renewal and circulation of intermediate waters in the Canadian Basin observed on the SCICEX 96 cruise

JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS, 105(C1), 1105–1121.

By: W. Smethie *, P. Schlosser*, G. Bonisch* & T. Hopkins n

UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Use of a mathematical model of rodent in vitro benzene metabolism to predict human in vitro metabolism data

CARCINOGENESIS, 20(8), 1511–1520.

By: M. Lovern n, M. Maris & P. Schlosser

MeSH headings : Animals; Benzene / metabolism; Carcinogens / metabolism; Cytochrome P-450 CYP2E1 / metabolism; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors / pharmacology; Humans; Male; Mice; Microsomes, Liver / drug effects; Microsomes, Liver / metabolism; Models, Biological; Quaternary Ammonium Compounds / pharmacology; Rats; Rats, Inbred F344; Trichloroepoxypropane / pharmacology
TL;DR: The goal was to improve existing mathematical models of microsomal benzene metabolism by including time course data for benzene oxide, by obtaining better parameter estimates and by determining if enzymes other than CYP2E1 are involved. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Application of a photographic method for determining mass transfer to flow around a submerged parallelepiped

INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER, 41(19), 2991–3004.

By: P. Schlosser*, M. Godo*, T. Fornes n & E. Hubal n

Source: Web Of Science
Added: August 6, 2018

1997 journal article

Identification of benzene oxide as a product of benzene metabolism by mouse, rat, and human liver microsomes

CARCINOGENESIS, 18(9), 1695–1700.

By: M. Lovern n, M. Turner, M. Meyer, G. Kedderis, W. Bechtold & P. Schlosser

MeSH headings : Animals; Benzene / metabolism; Chromatography, High Pressure Liquid; Cyclohexanes / metabolism; Gas Chromatography-Mass Spectrometry; Humans; Male; Mice; Microsomes, Liver / metabolism; Rats; Rats, Inbred F344; Species Specificity
TL;DR: The level of benzene oxide detected suggests that Benzene oxide is sufficiently stable to reach significant levels in the blood of mice, rats, and humans and may be translocated to the bone marrow and excluded as a possible metabolite involved in benzene-induced leukemogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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