Works (6)

Updated: September 6th, 2023 05:01

2023 article

The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Green, A. J., Cox, P. A., … Metcalf, J. S. (2023, August 8). The Effects of Long-term, Low-dose & beta;-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish. NEUROTOXICITY RESEARCH, Vol. 8.

By: R. Weeks n, S. Banack*, S. Howell n, P. Thunga n, A. Green*, P. Cox n, A. Planchart*, J. Metcalf n

author keywords: L-BMAA; D-BMAA; AEG; DAB; ALS; Zebrafish; Neurotoxicity; Neurodegeneration; SOD1
TL;DR: While the results revealed low concentrations of BMAA in the brains of exposed fish, there was no evidence of decreased swim performance or behavioral differences that might be reflective of neurodegenerative disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2023 article

The Effects of Long-term, Low-dose beta-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R (Aug, 10.1007/s12640-023-00658-z, 2023)

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 24). NEUROTOXICITY RESEARCH, Vol. 8.

By: R. Weeks n, S. Banack*, S. Howell n, P. Thunga n, J. Metcalf*, A. Green n, P. Cox*, A. Planchart n

Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2022 journal article

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

JOURNAL OF HAZARDOUS MATERIALS, 431.

By: L. Truong*, Y. Rericha*, P. Thunga n, S. Marvel n, D. Wallis n, M. Simonich*, J. Field*, D. Cao*, D. Reif n, R. Tanguay n

author keywords: PFAS; Developmental toxicity; Structure-activity relationship; Abnormal behavior; Zebrafish
MeSH headings : Animals; Fluorocarbons / analysis; Larva; Teratogens; Zebrafish
TL;DR: The results illustrate the power of a multi-dimensional in vivo platform to assess the developmental (neuro)toxicity of diverse PFAS and in the acceleration of PFAS safety research. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 8, 2022

2022 article

The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior

Shankar, P., Garcia, G. R., LaDu, J. K., Sullivan, C. M., Dunham, C. L., Goodale, B. C., … Tanguay, R. L. (2022, April 4). TOXICOLOGICAL SCIENCES, Vol. 4.

By: P. Shankar*, G. Garcia*, J. LaDu*, C. Sullivan*, C. Dunham*, B. Goodale*, K. Waters*, S. Stanisheuski* ...

author keywords: aryl hydrocarbon receptor (AHR); zebrafish; TCDD; wfikkn1; transcriptomics; behavior
MeSH headings : Animals; Embryo, Nonmammalian; Polychlorinated Dibenzodioxins / toxicity; Polycyclic Aromatic Hydrocarbons / toxicity; Proteome / genetics; Proteome / metabolism; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism; Transcriptome; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: Functional enrichment demonstrated wfikkn1 was involved in skeletal muscle development and played a role in neurological pathways after TCDD exposure, and was likely a necessary functional member of the AHR signaling cascade. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2022 journal article

Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure

TOXICS, 10(12).

By: P. Thunga n, L. Truong*, Y. Rericha*, J. Du*, M. Morshead*, R. Tanguay*, D. Reif n

author keywords: gene-environment interaction; chemical risk-assessment; zebrafish behavior; toxicity screening
TL;DR: It is demonstrated how standing genetic variation in a heterogeneous population such as the authors' can be leveraged to test for potential GxE by showing evidence that heritable genetics are directly affecting gene expression and behavioral susceptibility of individuals to PFHxA exposure. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2022

2021 journal article

Concurrent Evaluation of Mortality and Behavioral Responses: A Fast and Efficient Testing Approach for High-Throughput Chemical Hazard Identification

Frontiers in Toxicology, 3.

By: P. Thunga n, L. Truong*, R. Tanguay* & D. Reif n

TL;DR: It is found that combining information from behavioral and mortality assessments captures early signals of potential chemical hazards, obviating the need to evaluate a comprehensive suite of morphological endpoints in initial screens for toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: June 22, 2021

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