Preethi Thunga

Works (8)

Updated: April 24th, 2025 08:30

2024 article

Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

Green, A. J., Truong, L., Thunga, P., Leong, C., Hancock, M., Tanguay, R. L., & Reif, D. M. (2024, September 10). (S. V. Scarpino, Ed.). PLoS Computational Biology, Vol. 20.

By: A. Green n, L. Truong *, P. Thunga n , C. Leong*, M. Hancock n, R. Tanguay *, D. Reif n 

Ed(s): S. Scarpino

MeSH headings : Animals; Zebrafish / physiology; Behavior, Animal / drug effects; Deep Learning; Larva / drug effects; Pattern Recognition, Automated / methods; Computational Biology / methods; Neural Networks, Computer
topics (OpenAlex): Zebrafish Biomedical Research Applications; Fish Ecology and Management Studies; Bat Biology and Ecology Studies
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 15, 2024

2024 article

Diverse PFAS produce unique transcriptomic changes linked to developmental toxicity in zebrafish

Rericha, Y., Mary, L. S., Truong, L., McClure, R., Martin, J. K., Leonard, S. W., … Tanguay, R. L. (2024, July 22). Frontiers in Toxicology.

By: Y. Rericha *, L. Mary *, L. Truong *, R. McClure *, J. Martin*, S. Leonard *, P. Thunga n , M. Simonich * ...

author keywords: PFAS; developmental toxicity; transcriptomics; bioconcentration; phenotypically anchored
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Effects and risks of endocrine disrupting chemicals
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 14, 2024

2023 article

Correction to: The Effects of Long-term, Low-dose β-N-methylamino-L-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 24). Neurotoxicity Research, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , J. Metcalf *, A. Green n, P. Cox *, A. Planchart n 

topics (OpenAlex): Animal testing and alternatives; Animal Genetics and Reproduction; Cancer, Hypoxia, and Metabolism
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Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 article

The Effects of Long-term, Low-dose β-N-methylamino-l-alanine (BMAA) Exposures in Adult SODG93R Transgenic Zebrafish

Weeks, R. D., Banack, S. A., Howell, S., Thunga, P., Metcalf, J. S., Green, A. J., … Planchart, A. (2023, August 8). Neurotoxicity Research, Vol. 8.

By: R. Weeks n, S. Banack *, S. Howell n, P. Thunga n , J. Metcalf *, A. Green n, P. Cox *, A. Planchart n 

author keywords: L-BMAA; D-BMAA; AEG; DAB; ALS; Zebrafish; Neurotoxicity; Neurodegeneration; SOD1
MeSH headings : Animals; Zebrafish; Neurodegenerative Diseases / etiology; Amyotrophic Lateral Sclerosis / chemically induced; Amyotrophic Lateral Sclerosis / genetics; Amyotrophic Lateral Sclerosis / complications; Amino Acids, Diamino / toxicity; Animals, Genetically Modified; Neurotoxins / toxicity; Superoxide Dismutase
topics (OpenAlex): Amyotrophic Lateral Sclerosis Research; Neurogenetic and Muscular Disorders Research; Prion Diseases and Protein Misfolding
TL;DR: While the results revealed low concentrations of BMAA in the brains of exposed fish, there was no evidence of decreased swim performance or behavioral differences that might be reflective of neurodegenerative disease. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 21, 2023

2022 article

Systematic developmental toxicity assessment of a structurally diverse library of PFAS in zebrafish

Truong, L., Rericha, Y., Thunga, P., Marvel, S., Wallis, D., Simonich, M. T., … Tanguay, R. L. (2022, March 2). Journal of Hazardous Materials, Vol. 6, p. 128615.

By: L. Truong *, Y. Rericha *, P. Thunga n , S. Marvel n, D. Wallis n, M. Simonich *, J. Field *, D. Cao *, D. Reif n , R. Tanguay  n

author keywords: PFAS; Developmental toxicity; Structure-activity relationship; Abnormal behavior; Zebrafish
MeSH headings : Animals; Fluorocarbons / analysis; Larva; Teratogens; Zebrafish
topics (OpenAlex): Per- and polyfluoroalkyl substances research; Toxic Organic Pollutants Impact; Atmospheric chemistry and aerosols
TL;DR: The results illustrate the power of a multi-dimensional in vivo platform to assess the developmental (neuro)toxicity of diverse PFAS and in the acceleration of PFAS safety research. (via Semantic Scholar)
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6. Clean Water and Sanitation (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 8, 2022

2022 article

The Ahr2-Dependent wfikkn1 Gene Influences Zebrafish Transcriptome, Proteome, and Behavior

Shankar, P., Garcia, G. R., Du, J. K. L., Sullivan, C. M., Dunham, C. L., Goodale, B. C., … Tanguay, R. L. (2022, April 4). Toxicological Sciences, Vol. 4.

By: P. Shankar *, G. Garcia *, J. Du*, C. Sullivan *, C. Dunham *, B. Goodale *, K. Waters *, S. Stanisheuski* ...

author keywords: aryl hydrocarbon receptor (AHR); zebrafish; TCDD; wfikkn1; transcriptomics; behavior
MeSH headings : Animals; Embryo, Nonmammalian; Polychlorinated Dibenzodioxins / toxicity; Polycyclic Aromatic Hydrocarbons / toxicity; Proteome / genetics; Proteome / metabolism; Receptors, Aryl Hydrocarbon / genetics; Receptors, Aryl Hydrocarbon / metabolism; Transcriptome; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
topics (OpenAlex): Toxic Organic Pollutants Impact; Environmental Toxicology and Ecotoxicology; Effects and risks of endocrine disrupting chemicals
TL;DR: Functional enrichment demonstrated wfikkn1 was involved in skeletal muscle development and played a role in neurological pathways after TCDD exposure, and was likely a necessary functional member of the AHR signaling cascade. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2022 article

Utilizing a Population-Genetic Framework to Test for Gene-Environment Interactions between Zebrafish Behavior and Chemical Exposure

Thunga, P., Truong, L., Rericha, Y., Du, J., Morshead, M., Tanguay, R., & Reif, D. (2022, December 9). Toxics, Vol. 10.

By: P. Thunga n , L. Truong *, Y. Rericha *, J. Du*, M. Morshead *, R. Tanguay *, D. Reif n 

author keywords: gene-environment interaction; chemical risk-assessment; zebrafish behavior; toxicity screening
topics (OpenAlex): Health, Environment, Cognitive Aging; Birth, Development, and Health; Effects and risks of endocrine disrupting chemicals
TL;DR: It is demonstrated how standing genetic variation in a heterogeneous population such as the authors' can be leveraged to test for potential GxE by showing evidence that heritable genetics are directly affecting gene expression and behavioral susceptibility of individuals to PFHxA exposure. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 10, 2022

2021 article

Concurrent Evaluation of Mortality and Behavioral Responses: A Fast and Efficient Testing Approach for High-Throughput Chemical Hazard Identification

Thunga, P., Truong, L., Tanguay, R. L., & Reif, D. M. (2021, June 15). Frontiers in Toxicology, Vol. 3.

By: P. Thunga n , L. Truong *, R. Tanguay * & D. Reif n 

topics (OpenAlex): Environmental Toxicology and Ecotoxicology; Animal testing and alternatives; Zebrafish Biomedical Research Applications
TL;DR: It is found that combining information from behavioral and mortality assessments captures early signals of potential chemical hazards, obviating the need to evaluate a comprehensive suite of morphological endpoints in initial screens for toxicity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: June 22, 2021

Employment

Updated: August 14th, 2025 16:08

Vertex Pharmaceuticals (United States) Boston, Massachusetts, US
Data and Computational Sciences

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