Works (29)

Updated: August 23rd, 2023 21:14

2019 journal article

Use of a Branched Linker for Enhanced Biosensing Properties in IgG Detection from Mixed Chinese Hamster Ovary Cell Cultures

BIOCONJUGATE CHEMISTRY, 30(3), 815โ€“825.

By: N. Islam n, P. Gurgel n, O. Rojas n & R. Carbonell n

co-author countries: Bangladesh ๐Ÿ‡ง๐Ÿ‡ฉ Finland ๐Ÿ‡ซ๐Ÿ‡ฎ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adsorption; Amino Acid Sequence; Animals; Biosensing Techniques; CHO Cells; Complex Mixtures; Cricetinae; Cricetulus; Immunoglobulin G / analysis; Kinetics; Peptides / chemistry
Source: Web Of Science
Added: April 9, 2019

2016 journal article

Affinity interactions of human immunoglobulin G with short peptides: role of ligand spacer on binding, kinetics, and mass transfer

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 408(7), 1829โ€“1841.

By: F. Shenโ€‰ n, O. Rojas n, J. Genzer nโ€‰, P. Gurgel n & R. Carbonell n

co-author countries: Finland ๐Ÿ‡ซ๐Ÿ‡ฎ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Peptide ligands; Immunoglobulin G; Peptide HWRGWV; Spacer arms; Quartz crystal microbalance
MeSH headings : Adsorption; Amino Acid Sequence; Humans; Immunoglobulin G / metabolism; Kinetics; Ligands; Peptides / chemistry; Peptides / metabolism; Polyethylene Glycols / chemistry; Protein Binding; Quartz Crystal Microbalance Techniques / methods; Silicon Dioxide / chemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Reducing diffusion limitations in Ion exchange grafted membranes using high surface area nonwovens

JOURNAL OF MEMBRANE SCIENCE, 514, 53โ€“64.

By: M. Heller n, R. Wimbish n, P. Gurgel n, B. Pourdeyhimi nโ€‰ & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: UV grafting; Islands-in-the-sea nonwoven; Diffusion limited; Ion exchange protein capture; Shrinking core
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Preparation and characterization of anion exchange adsorptive nonwoven membranes with high protein binding capacity

JOURNAL OF MEMBRANE SCIENCE, 493, 349โ€“359.

By: H. Liu n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Anion exchange membrane; Protein purification; Nonwoven surface modification; High protein binding capacity; hIgG separation
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Dynamic and equilibrium performance of sensors based on short peptide ligands for affinity adsorption of human IgG using surface plasmon resonance

BIOSENSORS & BIOELECTRONICS, 58, 380โ€“387.

By: N. Islam n, F. Shenโ€‰ n, P. Gurgel n, O. Rojas n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Hexamer; Protein A; Human immunoglobulin G; Self-assembled monolayers; Adsorption rate constant; Desorption rate constant
MeSH headings : Adsorption; Antibody Affinity / immunology; Binding Sites; Biosensing Techniques / instrumentation; Equipment Design; Equipment Failure Analysis; Immunoglobulin G / chemistry; Immunoglobulin G / immunology; Peptides / chemistry; Peptides / immunology; Protein Binding; Protein Interaction Mapping / instrumentation; Surface Plasmon Resonance / instrumentation
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Effects of Composition of Oligo(ethylene glycol)-Based Mixed Monolayers on Peptide Grafting and Human Immunoglobulin Detection

JOURNAL OF PHYSICAL CHEMISTRY C, 118(10), 5361โ€“5373.

By: N. Islam n, P. Gurgel n, O. Rojas n & R. Carbonell n

co-author countries: Finland ๐Ÿ‡ซ๐Ÿ‡ฎ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Affinity chromatographic purification of human immunoglobulin M from human B lymphocyte cell culture supernatant

BIOCHEMICAL ENGINEERING JOURNAL, 70, 63โ€“70.

By: Z. Liu*, P. Gurgel* & R. Carbonell*

author keywords: Affinity chromatography; Hexamer peptide; Human immunoglobulin; IgM; Dynamic binding capacity; Elution additive
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Affinity chromatographic purification of human immunoglobulin a from chinese hamster ovary cell culture supernatant

BIOTECHNOLOGY PROGRESS, 29(1), 91โ€“98.

By: Z. Liu n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: affinity chromatography; hexamer peptide; CHO; human immunoglobulin; secretory IgA
MeSH headings : Adsorption; Animals; CHO Cells; Cells, Cultured; Chromatography, Affinity; Cricetinae; Cricetulus; Humans; Immunoglobulin A / isolation & purification; Oligopeptides / chemical synthesis; Oligopeptides / chemistry; Surface Properties
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Alkaline-stable peptide ligand affinity adsorbents for the purification of biomolecules

Journal of Chromatography A, 1245, 55โ€“64.

By: S. Menegatti nโ€‰, A. Naik n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Peptide ligand; Affinity adsorbent; NaOH stability; Modification of surface chemistry; Solid-phase peptide synthesis; Cleaning-in-place
MeSH headings : Adsorption; Alkalies / chemistry; Chromatography, Affinity / instrumentation; Chromatography, Affinity / methods; Immunoglobulin G / chemistry; Immunoglobulin G / isolation & purification; Ligands; Peptides / chemistry; Protein Binding
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Porcine parvovirus removal using trimer and biased hexamer peptides

Biotechnology Journal, 7(4), 558โ€“565.

By: C. Heldt n, P. Gurgel n, L. Jaykus n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Affinity adsorption; Biosafety; Bioseparation; Ligand; Virus removal
MeSH headings : Adsorption; Chromatography, Affinity; Humans; Parvovirus, Porcine / chemistry; Parvovirus, Porcine / isolation & purification; Peptides / chemical synthesis; Peptides / chemistry; Plasma / chemistry; Plasma / virology
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Process for purification of monoclonal antibody expressed in transgenic Lemna plant extract using dextran-coated charcoal and hexamer peptide affinity resin

Journal of Chromatography A, 1260, 61โ€“66.

By: A. Naik n, S. Menegatti nโ€‰, H. Reese n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Dextran-coated charcoal; Transgenic plants; Hexapeptide ligand; IgG purification; Monoclonal antibody; Phenolics; Lemna minor
MeSH headings : Antibodies, Monoclonal / isolation & purification; Antibodies, Monoclonal / metabolism; Araceae / chemistry; Araceae / metabolism; Charcoal / chemistry; Chromatography, Affinity / methods; Dextrans / chemistry; Humans; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Peptides / chemistry; Peptides / metabolism; Plant Extracts / chemistry; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / metabolism; Protein Binding; Staphylococcal Protein A / chemistry; Staphylococcal Protein A / isolation & purification
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Purification of human immunoglobulins A, G and M from Cohn fraction II/III by small peptide affinity chromatography

JOURNAL OF CHROMATOGRAPHY A, 1262, 169โ€“179.

By: Z. Liu n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Hexamer peptide; IVIG; Cohn fraction; Elution additive; PEG; Ammonium sulfate
MeSH headings : Ammonium Sulfate / chemistry; Arginine / chemistry; Blood Proteins / chemistry; Caprylates / chemistry; Chromatography, Affinity / methods; Ethylene Glycols / chemistry; Humans; Immunoglobulin Isotypes / blood; Immunoglobulin Isotypes / isolation & purification; Peptides / chemistry; Salts / chemistry
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Effects of UV Exposure and Initiator Concentration on the Spatial Variation of Poly(glycidyl methacrylate) Grafts on Nonwoven Fabrics

INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 50(10), 6115โ€“6123.

By: Y. Zheng, P. Gurgel* & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Effects of peptide density and elution pH on affinity chromatographic purification of human immunoglobulins A and M

JOURNAL OF CHROMATOGRAPHY A, 1218(46), 8344โ€“8352.

By: Z. Liu n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Human immunoglobulin; IgG; IgA; IgM; Affinity chromatography; Binding site
MeSH headings : Amino Acid Sequence; Binding Sites; Chromatography, Affinity / instrumentation; Chromatography, Affinity / methods; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Immunoglobulin A / chemistry; Immunoglobulin A / isolation & purification; Immunoglobulin M / chemistry; Immunoglobulin M / isolation & purification; Immunosorbent Techniques; Molecular Sequence Data; Oligopeptides / chemistry; Protein Conformation; Sequence Alignment
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media

Journal of Chromatography A, 1218(13), 1691โ€“1700.

By: A. Naik n, S. Menegatti nโ€‰, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Hexapeptide ligand; IgG purification; Monoclonal antibody; Affinity chromatography; Regeneration
MeSH headings : Adsorption; Animals; Antibodies, Monoclonal / chemistry; Antibodies, Monoclonal / isolation & purification; CHO Cells; Caprylates; Cell Culture Techniques; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Culture Media; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G / chemistry; Immunoglobulin G / isolation & purification; Oligopeptides / chemistry; Phosphoric Acids; Protein Binding; Sodium Chloride; Urea
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Binding site on human immunoglobulin G for the affinity ligand HWRGWV

Journal of Molecular Recognition, 23(3), 271โ€“282.

By: H. Yang, P. Gurgel, D. Williams, B. Bobay, J. Cavanagh, D. Muddimanโ€‰, R. Carbonell

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Purification of human immunoglobulin G via Fc-specific small peptide ligand affinity chromatography

JOURNAL OF CHROMATOGRAPHY A, 1216(6), 910โ€“918.

By: H. Yang n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Human immunoglobulin G; Fc fragment; Hexamer peptide ligand; Affinity chromatography; Ligand density
MeSH headings : Adsorption; Chromatography, Affinity / methods; Culture Media; Humans; Immobilized Proteins / chemistry; Immobilized Proteins / metabolism; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Kinetics; Ligands; Peptides / chemistry; Peptides / metabolism; Temperature
Source: Web Of Science
Added: August 6, 2018

2008 article

Identification of trimeric peptides that bind porcine parvovirus from mixtures containing human blood plasma

BIOTECHNOLOGY PROGRESS, Vol. 24, pp. 554โ€“560.

By: C. Heldt n, P. Gurgel n, L. Jaykus n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Complex Mixtures / isolation & purification; Complex Mixtures / metabolism; Humans; Oligopeptides / metabolism; Parvovirus, Porcine / isolation & purification; Parvovirus, Porcine / metabolism; Plasma / metabolism; Plasma / virology
Source: Web Of Science
Added: August 6, 2018

2008 patent

Prion protein binding materials and methods of use

Washington, DC: U.S. Patent and Trademark Office.

By: R. Carbonell, H. Shen, P. Gurgel, V. Wiltshire-Lyerly, D. Hammond & S. Burton

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

A colorimetric assay for viral agents that produce cytopathic effects

Journal of Virological Methods, 135(1), 56โ€“65.

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Reduction in infectivity of endogenous transmissible spongiform encephalopathies present in blood by adsorption to selective affinity resins

LANCET, 368(9554), 2226โ€“2230.

By: L. Gregori*, P. Gurgel*, J. Lathrop*, P. Edwardson, B. Lambert*, R. Carbonell n, S. Burton, D. Hammond*, R. Rohwer*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adsorption; Animals; Cricetinae; Filtration / methods; Prion Diseases / prevention & control; Prion Diseases / transmission; Prions / blood; Prions / isolation & purification; Prions / pathogenicity; Transfusion Reaction
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Reduction of transmissible spongiform encephalopathy infectivity from human red blood cells with prion protein affinity ligands

TRANSFUSION, 46(7), 1152โ€“1161.

By: L. Gregori n, B. Lambert n, P. Gurgel n, L. Gheorghiu n, P. Edwardson n, J. Lathrop n, C. MacAuley n, R. Carbonell n ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Combinatorial Chemistry Techniques; Cricetinae; Erythrocyte Transfusion / methods; Erythrocyte Transfusion / standards; Erythrocytes / chemistry; Humans; Ligands; Models, Biological; Prion Diseases / prevention & control; Prions / blood; Prions / isolation & purification; Protein Binding; Titrimetry
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Hexamer peptide affinity resins that bind the Fc region of human immunoglobulin G

JOURNAL OF PEPTIDE RESEARCH, 66, 120โ€“137.

By: H. Yang n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: affinity chromatography; Fc fragment; hexapeptide; immunoglobulin
Source: Web Of Science
Added: August 6, 2018

2005 article

Small Peptide Ligands for Affinity Separations of Biological Molecules

CHEMICAL ENGINEERING TRENDS AND DEVELOPMENTS, pp. 63โ€“83.

By: G. Wang n, J. Salm n, P. Gurgel n & R. Carbonell n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Identification of peptide ligands generated by combinatorial chemistry that bind alpha-lactalbumin

SEPARATION SCIENCE AND TECHNOLOGY, 36(11), 2411โ€“2431.

By: P. Gurgel n, R. Carbonell n & H. Swaisgood n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Studies of the binding of alpha-lactalbumin to immobilized peptide ligands

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 49(12), 5765โ€“5770.

By: P. Gurgel n, R. Carbonell n & H. Swaisgood n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: alpha-lactalbumin; peptide ligands; bioselective adsorption; binding mechanism
MeSH headings : Adsorption; Amino Acid Sequence; Lactalbumin / metabolism; Ligands; Mutagenesis, Site-Directed; Oligopeptides / metabolism; Protein Binding; Protein Precursors / metabolism; Recombinant Proteins / metabolism; Resins, Plant; Thermodynamics
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Fractionation of whey proteins with a hexapeptide ligand affinity resin

BIOSEPARATION, 9(6), 385โ€“392.

By: P. Gurgel n, R. Carbonell n & H. Swaisgood n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: alpha-lactalbumin; bioselective adsorption; peptide ligands; whey protein isolate
MeSH headings : Animals; Cattle; Chromatography, Affinity / methods; Lactalbumin / isolation & purification; Ligands; Milk Proteins / isolation & purification; Oligopeptides; Resins, Synthetic; Whey Proteins
Source: Web Of Science
Added: August 6, 2018

patent

Prion protein binding materials and methods of use

Hammond, D. J., Carbonell, R. G., Shen, H., Gurgel, P. V., Wiltshire-Lyerly, V., & Burton, S. J.

By: D. Hammond, R. Carbonell, H. Shen, P. Gurgel, V. Wiltshire-Lyerly & S. Burton

Source: NC State University Libraries
Added: August 6, 2018

patent

Purification of immunoglobulins using affinity chromatography and peptide ligands

Carbonell, R. G., Yang, H., & Gurgel, P. V. Washington, DC: U.S. Patent and Trademark Office.

By: R. Carbonell, H. Yang & P. Gurgel

Source: NC State University Libraries
Added: August 6, 2018

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