Qian Chen

Works (14)

Updated: September 16th, 2024 08:21

2019 journal article

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

ADVANCED MATERIALS, 31(17).

By: H. Ruan  n, Q. Hu n, D. Wen n, Q. Chen n, G. Chen n, Y. Lu  n, J. Wang n, H. Cheng *, W. Lu *, Z. Gu n

author keywords: bioresponsive materials; drug delivery; epigenetic modulation; immune checkpoint blockade; immunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Calcium Carbonate / chemistry; Cell Line, Tumor; Cytidine / analogs & derivatives; Cytidine / pharmacology; Drug Delivery Systems / methods; Drug Liberation; Drug Therapy, Combination / methods; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents / chemistry; Immunosuppressive Agents / pharmacology; Immunotherapy / methods; Melanoma / drug therapy; Nanoparticles / chemistry; Programmed Cell Death 1 Receptor / metabolism; Reactive Oxygen Species / metabolism; Tumor Microenvironment / drug effects
topics (OpenAlex): Nanoplatforms for cancer theranostics; Cancer Immunotherapy and Biomarkers; Immunotherapy and Immune Responses
TL;DR: It is demonstrated that this combination therapy increases the immunogenicity of cancer cells, and also plays roles in reversing immunosuppressive TME, which contributes to inhibiting the tumor growth and prolonging the survival time of B16F10‐melanoma‐bearing mice. (via Semantic Scholar)
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Source: Web Of Science
Added: May 13, 2019

2019 journal article

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

ACS NANO, 13(4), 4354–4360.

By: G. Yang  n, Q. Chen n, D. Wen n, Z. Chen n, J. Wang n, G. Chen n, Z. Wang *, X. Zhang n ...

author keywords: drug delivery; microneedle; exosome; keratin; hair regrowth; transdermal drug delivery
MeSH headings : Animals; Cell Line; Delayed-Action Preparations / chemistry; Drug Delivery Systems / instrumentation; Equipment Design; Hair / chemistry; Hair / drug effects; Hair / growth & development; Hair Follicle / drug effects; Hair Follicle / growth & development; Humans; Injections, Subcutaneous; Keratins / chemistry; Mice, Inbred C57BL; Transdermal Patch
topics (OpenAlex): Hair Growth and Disorders; Advancements in Transdermal Drug Delivery; Skin and Cellular Biology Research
TL;DR: It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 4, 2019

2019 journal article

Bioresponsive Protein Complex of aPD1 and aCD47 Antibodies for Enhanced Immunotherapy

NANO LETTERS, 19(8), 4879–4889.

By: Q. Chen n, G. Chen*, J. Chen *, J. Shen *, X. Zhang*, J. Wang n, A. Chan *, Z. Gu n

author keywords: Drug delivery; immunotherapy; immune checkpoint blockade; bioresponsive; nanomedicine
MeSH headings : Animals; Antibodies, Monoclonal / immunology; Antibodies, Monoclonal / therapeutic use; Antineoplastic Agents, Immunological / immunology; Antineoplastic Agents, Immunological / therapeutic use; CD47 Antigen / immunology; Female; Immunotherapy; Melanoma / immunology; Melanoma / therapy; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / immunology; Reactive Oxygen Species / immunology; Tumor Microenvironment / drug effects
topics (OpenAlex): Cancer Immunotherapy and Biomarkers; Nanoplatforms for cancer theranostics; Immune cells in cancer
TL;DR: A bioresponsive ICB treatment is developed based on the reactive oxygen species (ROS)-sensitive protein complex for controlled sequential release of anti- "don't eat me" signal antibody and antiprogrammed cell death protein 1 (aPD1), by leveraging the abundant ROS in the tumor microenvironment. (via Semantic Scholar)
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Source: Web Of Science
Added: September 3, 2019

2019 journal article

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

NATURE NANOTECHNOLOGY, 14(1), 89-+.

By: Q. Chen*, C. Wang  n, X. Zhang*, G. Chen*, Q. Hu*, H. Li*, J. Wang n, D. Wen* ...

MeSH headings : Animals; Biocompatible Materials / chemistry; Calcium Carbonate / chemistry; Female; Fibrin / chemistry; Gels / chemistry; Humans; Immunity; Immunotherapy / methods; Luminescent Measurements; Melanoma, Experimental / pathology; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Phagocytosis
topics (OpenAlex): Phagocytosis and Immune Regulation; Nanoplatforms for cancer theranostics; Immune cells in cancer
TL;DR: The findings indicate that the immunotherapeutic fibrin gel ‘awakens’ the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 21, 2019

2019 journal article

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

ADVANCED MATERIALS, 31(23).

By: Q. Chen n, Q. Hu n, E. Dukhovlinova *, G. Chen*, S. Ahn*, C. Wang n, E. Ogunnaike  n, F. Ligler n, G. Dotti*, Z. Gu n

author keywords: CAR T cells; cell therapy; drug delivery; immunotherapy; photothermal therapy
MeSH headings : Animals; Antigens / metabolism; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans / metabolism; Combined Modality Therapy; Female; Heterografts; Humans; Hyperthermia, Induced; Immunotherapy, Adoptive / methods; Indocyanine Green / chemistry; Melanoma / pathology; Melanoma / therapy; Membrane Proteins / metabolism; Mice, SCID; Nanoparticles / chemistry; Photosensitizing Agents / chemistry; Phototherapy / methods; Polylactic Acid-Polyglycolic Acid Copolymer / chemistry; Proteoglycans / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / therapy; T-Lymphocytes / metabolism; T-Lymphocytes / transplantation; Tumor Microenvironment
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Nanowire Synthesis and Applications
TL;DR: It is found that the chondroitin sulfate proteoglycan‐4 (CSPG4)‐specific CAR T cells infused in Nod scid gamma mice engrafted with the human melanoma WM115 cell line have superior antitumor activity after photothermal ablation of the tumor. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 22, 2019

2019 journal article

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

NANO RESEARCH, 12(6), 1313–1320.

By: J. Yan  n, X. Zhang n, Y. Liu n, Y. Ye n, J. Yu n, Q. Chen n, J. Wang n, Y. Zhang n ...

author keywords: liquid metal; melanin nanoparticles; nanomedicine; shape-controlled synthesis; photothermal therapy
topics (OpenAlex): Gold and Silver Nanoparticles Synthesis and Applications; Extracellular vesicles in disease; Quantum Dots Synthesis And Properties
TL;DR: Interestingly, shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs, and among these shapes, EGaIn nanorice has the best photothermal conversion efficiency, which could be leveraged for photothermal therapy. (via Semantic Scholar)
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Source: Web Of Science
Added: June 17, 2019

2018 journal article

A method for determining density based on gamma ray and fast neutron detection using a Cs2LiYCl6 detector in neutron-gamma density logging

APPLIED RADIATION AND ISOTOPES, 142, 77–84.

By: Q. Zhang n, F. Zhang *, R. Gardner n, H. Yan *, G. Wu *, L. Tian *, Q. Chen*, Y. Ti*

author keywords: Pulsed neutron-gamma density; CLYC detector; Monte Carlo simulation; Fast neutron; Inelastic gamma
topics (OpenAlex): Nuclear Physics and Applications; Radiation Detection and Scintillator Technologies; Nuclear reactor physics and engineering
TL;DR: A new density measurement method based on the fast neutron-gamma coupled theory is proposed, capable of determining formation density using a single CLYC detector, which can not only avoid complex instrument systems but also improve density sensitivity. (via Semantic Scholar)
Source: Web Of Science
Added: January 14, 2019

2018 journal article

Advances in transformable drug delivery systems

BIOMATERIALS, 178, 546–558.

By: Q. Hu n, Q. Chen n & Z. Gu n

author keywords: Drug delivery; Stimuli-responsive; Cancer therapy; Transformable formulation
MeSH headings : Animals; Drug Delivery Systems / methods; Extracellular Space / chemistry; Humans; Intracellular Space / chemistry; Microbubbles; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / diagnosis; Neoplasms / pathology
topics (OpenAlex): 3D Printing in Biomedical Research; Innovative Microfluidic and Catalytic Techniques Innovation; Nanoparticle-Based Drug Delivery
TL;DR: This review describes the recently developed intracelluarly and extracellularly transformable DDSs, especially associated with assembly or disassociation of the original formulation units, for achieving various functionalities, including prolonged retention time, inhibited endocytosis and enhanced cytotoxicity. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Delivery Strategies for Immune Checkpoint Blockade

ADVANCED HEALTHCARE MATERIALS, 7(20).

By: Q. Chen n, C. Wang  n, G. Chen n, Q. Hu n & Z. Gu n

author keywords: biomaterials; cancer therapy; drug delivery; immune checkpoint blockade; immunotherapy
MeSH headings : Autoimmune Diseases / immunology; Autoimmune Diseases / therapy; Humans; Immunotherapy / methods; Neoplasms / immunology; Neoplasms / therapy
topics (OpenAlex): Cancer Immunotherapy and Biomarkers; Immune Cell Function and Interaction; Lung Cancer Research Studies
TL;DR: A brief review summarizes strategies to increase the antitumor immunity, including the local and targeted delivery of checkpoint inhibitors, and a combination of different checkpoint inhibitors or with other therapeutic treatments. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 19, 2018

2018 journal article

Quantitative monitoring of CO2 sequestration using thermal neutron detection technique in heavy oil reservoirs

INTERNATIONAL JOURNAL OF GREENHOUSE GAS CONTROL, 79, 154–164.

By: F. Zhang *, Q. Zhang n, R. Gardner n, J. Liu*, X. Zhang *, F. Qiu*, Q. Chen*, L. Tian *, Y. Wang *

author keywords: CO2 saturation; Heavy oil; Thermal neutron detection; Influence factor; Monte Carlo simulation
topics (OpenAlex): Hydrocarbon exploration and reservoir analysis; CO2 Sequestration and Geologic Interactions; Enhanced Oil Recovery Techniques
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13. Climate Action (Web of Science)
16. Peace, Justice and Strong Institutions (OpenAlex)
Source: Web Of Science
Added: December 17, 2018

2012 article

A Low-Loss Gate Drive for Emitter Turn-Off Thyristor (ETO)

Chen, Q., & Huang, A. Q. (2012, December). IEEE TRANSACTIONS ON POWER ELECTRONICS, Vol. 27, pp. 4827–4831.

By: Q. Chen n & A. Huang n

author keywords: Emitter turn-off thyristor (ETO); gate-commutated thyristor (GCT); gate drive; integrated gate-commutated thyristor (IGCT); self-power
topics (OpenAlex): Silicon Carbide Semiconductor Technologies; Advancements in Semiconductor Devices and Circuit Design; Semiconductor materials and devices
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7. Affordable and Clean Energy (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2012 conference paper

Self-power emitter turn-off thyristor (SPETO) based circuit breaker for power distribution system

2012 IEEE Energy Conversion Congress and Exposition (ECCE), 2017–2021.

By: Q. Chen n, K. Tan n & A. Huang n

topics (OpenAlex): High-Voltage Power Transmission Systems; Silicon Carbide Semiconductor Technologies; Smart Grid and Power Systems
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2011 conference paper

Analysis of impact of self-power function on emitter turn-off thyristor

2011 IEEE Energy Conversion Congress and Exposition (ECCE), 1868–1872.

By: Q. Chen n & A. Huang n

topics (OpenAlex): Silicon Carbide Semiconductor Technologies; Magnetic Properties and Applications; High-Voltage Power Transmission Systems
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

2010 conference paper

Improvement of gate drive for self-power emitter turn-off thyristor (speto)

Iecon 2010: 36th annual conference of the ieee industrial electronics society.

By: Q. Chen n & A. Huang n

topics (OpenAlex): Silicon Carbide Semiconductor Technologies; Magnetic Properties and Applications; Induction Heating and Inverter Technology
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018

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