Quanyin Hu

Works (38)

Updated: April 25th, 2025 17:37

2021 article

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Hu, Q., Li, H., Archibong, E., Chen, Q., Ruan, H., Ahn, S., … Gu, Z. (2021, April 26). Nature Biomedical Engineering.

By: Q. Hu n, H. Li *, E. Archibong n, Q. Chen  n, H. Ruan *, S. Ahn*, E. Dukhovlinova *, Y. Kang * ...

MeSH headings : Animals; Antibodies, Monoclonal, Humanized; Blood Platelets; Cell-Derived Microparticles; Hydrogels; Immunotherapy, Adoptive; Mice; Neoplasm Recurrence, Local / prevention & control; T-Lymphocytes; Tumor Microenvironment
topics (OpenAlex): CAR-T cell therapy research; Immune Cell Function and Interaction; Immunotherapy and Immune Responses
TL;DR: A hydrogel implanted into the cavity of a resected tumour and releasing CAR-T cells and platelets conjugated with a checkpoint inhibitor inhibits local tumour recurrence and the growth of distant tumours in mice. (via Semantic Scholar)
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Added: June 10, 2021

2021 article

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

Li, H., Wang, Z., Ogunnaike, E. A., Wu, Q., Chen, G., Hu, Q., … Gu, Z. (2021, September 13). National Science Review.

By: H. Li *, Z. Wang *, E. Ogunnaike *, Q. Wu *, G. Chen*, Q. Hu n, T. Ci *, Z. Chen* ...

author keywords: drug delivery; CAR T therapy; microneedle patch; solid tumor treatment; cell delivery
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Viral Infectious Diseases and Gene Expression in Insects
TL;DR: A porous microneedle patch is implemented that accommodates CAR T cells and allows in situ penetration-mediated seeding ofCAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. (via Semantic Scholar)
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Added: March 28, 2022

2020 article

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

Sun, W., Wang, J., Hu, Q., Zhou, X., Khademhosseini, A., & Gu, Z. (2020, May 20). Science Advances.

By: W. Sun n, J. Wang n, Q. Hu n, X. Zhou *, A. Khademhosseini * & Z. Gu n

MeSH headings : CRISPR-Cas Systems; Cholesterol; DNA / genetics; DNA / metabolism; Gene Editing; Polymers / metabolism; Proprotein Convertase 9 / genetics; Proprotein Convertase 9 / metabolism; RNA / genetics; Ribonucleoproteins / genetics
topics (OpenAlex): CRISPR and Genetic Engineering; Innovation and Socioeconomic Development; Mosquito-borne diseases and control
TL;DR: A DNA nanoclew (NC)-based carrier for delivery of Cas12a/CRISPR RNA (crRNA) ribonucleoprotein (R NP) toward regulating serum cholesterol levels and significantly reducing the expression of PCSK9 and gaining the therapeutic benefit of cholesterol control. (via Semantic Scholar)
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Added: June 22, 2020

2019 article

A Dual‐Bioresponsive Drug‐Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

Ruan, H., Hu, Q., Wen, D., Chen, Q., Chen, G., Lu, Y., … Gu, Z. (2019, March 11). Advanced Materials.

By: H. Ruan  n, Q. Hu n, D. Wen n, Q. Chen n, G. Chen n, Y. Lu  n, J. Wang n, H. Cheng *, W. Lu *, Z. Gu n

author keywords: bioresponsive materials; drug delivery; epigenetic modulation; immune checkpoint blockade; immunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Calcium Carbonate / chemistry; Cell Line, Tumor; Cytidine / analogs & derivatives; Cytidine / pharmacology; Drug Delivery Systems / methods; Drug Liberation; Drug Therapy, Combination / methods; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents / chemistry; Immunosuppressive Agents / pharmacology; Immunotherapy / methods; Melanoma / drug therapy; Nanoparticles / chemistry; Programmed Cell Death 1 Receptor / metabolism; Reactive Oxygen Species / metabolism; Tumor Microenvironment / drug effects
topics (OpenAlex): Nanoplatforms for cancer theranostics; Cancer Immunotherapy and Biomarkers; Immunotherapy and Immune Responses
TL;DR: It is demonstrated that this combination therapy increases the immunogenicity of cancer cells, and also plays roles in reversing immunosuppressive TME, which contributes to inhibiting the tumor growth and prolonging the survival time of B16F10‐melanoma‐bearing mice. (via Semantic Scholar)
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Added: May 13, 2019

2019 article

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

Yang, G., Chen, Q., Wen, D., Chen, Z., Wang, J., Chen, G., … Gu, Z. (2019, April 3). ACS Nano.

By: G. Yang  n, Q. Chen n, D. Wen n, Z. Chen n, J. Wang n, G. Chen n, Z. Wang *, X. Zhang n ...

author keywords: drug delivery; microneedle; exosome; keratin; hair regrowth; transdermal drug delivery
MeSH headings : Animals; Cell Line; Delayed-Action Preparations / chemistry; Drug Delivery Systems / instrumentation; Equipment Design; Hair / chemistry; Hair / drug effects; Hair / growth & development; Hair Follicle / drug effects; Hair Follicle / growth & development; Humans; Injections, Subcutaneous; Keratins / chemistry; Mice, Inbred C57BL; Transdermal Patch
topics (OpenAlex): Hair Growth and Disorders; Advancements in Transdermal Drug Delivery; Skin and Cellular Biology Research
TL;DR: It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. (via Semantic Scholar)
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Added: June 4, 2019

2019 article

Adipocytes as Anticancer Drug Delivery Depot

Wen, D., Wang, J., Driessche, G. V. D., Chen, Q., Zhang, Y., Chen, G., … Gu, Z. (2019, September 25). Matter.

By: D. Wen n, J. Wang n, G. Driessche n, Q. Chen  n, Y. Zhang n, G. Chen n, H. Li *, J. Soto * ...

topics (OpenAlex): Immune cells in cancer; Cancer, Stress, Anesthesia, and Immune Response; Adipose Tissue and Metabolism
TL;DR: The lipid metabolism is exploited to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site, promoting antitumor efficacy and downregulation of PD-L1 expression is observed in tumor cells. (via Semantic Scholar)
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Added: April 6, 2020

2019 article

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

Chen, Q., Hu, Q., Dukhovlinova, E., Chen, G., Ahn, S., Wang, C., … Gu, Z. (2019, March 27). Advanced Materials.

By: Q. Chen n, Q. Hu n, E. Dukhovlinova *, G. Chen*, S. Ahn*, C. Wang n, E. Ogunnaike  n, F. Ligler n, G. Dotti*, Z. Gu n

author keywords: CAR T cells; cell therapy; drug delivery; immunotherapy; photothermal therapy
MeSH headings : Animals; Antigens / metabolism; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans / metabolism; Combined Modality Therapy; Female; Heterografts; Humans; Hyperthermia, Induced; Immunotherapy, Adoptive / methods; Indocyanine Green / chemistry; Melanoma / pathology; Melanoma / therapy; Membrane Proteins / metabolism; Mice, SCID; Nanoparticles / chemistry; Photosensitizing Agents / chemistry; Phototherapy / methods; Polylactic Acid-Polyglycolic Acid Copolymer / chemistry; Proteoglycans / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / therapy; T-Lymphocytes / metabolism; T-Lymphocytes / transplantation; Tumor Microenvironment
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Nanowire Synthesis and Applications
TL;DR: It is found that the chondroitin sulfate proteoglycan‐4 (CSPG4)‐specific CAR T cells infused in Nod scid gamma mice engrafted with the human melanoma WM115 cell line have superior antitumor activity after photothermal ablation of the tumor. (via Semantic Scholar)
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Added: July 22, 2019

2018 article

Advances in transformable drug delivery systems

Hu, Q., Chen, Q., & Gu, Z. (2018, April 5). Biomaterials.

By: Q. Hu n, Q. Chen n & Z. Gu n

author keywords: Drug delivery; Stimuli-responsive; Cancer therapy; Transformable formulation
MeSH headings : Animals; Drug Delivery Systems / methods; Extracellular Space / chemistry; Humans; Intracellular Space / chemistry; Microbubbles; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / diagnosis; Neoplasms / pathology
topics (OpenAlex): 3D Printing in Biomedical Research; Innovative Microfluidic and Catalytic Techniques Innovation; Nanoparticle-Based Drug Delivery
TL;DR: This review describes the recently developed intracelluarly and extracellularly transformable DDSs, especially associated with assembly or disassociation of the original formulation units, for achieving various functionalities, including prolonged retention time, inhibited endocytosis and enhanced cytotoxicity. (via Semantic Scholar)
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Added: October 19, 2018

2018 article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

Hu, Q., Sun, W., Wang, J., Ruan, H., Zhang, X., Ye, Y., … Gu, Z. (2018, October 17). Nature Biomedical Engineering.

By: Q. Hu n, W. Sun*, J. Wang n, H. Ruan  n, X. Zhang*, Y. Ye n, S. Shen *, C. Wang  n ...

MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
topics (OpenAlex): Hematopoietic Stem Cell Transplantation; Immune Cell Function and Interaction; CAR-T cell therapy research
TL;DR: It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade. (via Semantic Scholar)
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Added: November 26, 2018

2018 article

Delivery Strategies for Immune Checkpoint Blockade

Chen, Q., Wang, C., Chen, G., Hu, Q., & Gu, Z. (2018, July 5). Advanced Healthcare Materials.

By: Q. Chen n, C. Wang  n, G. Chen n, Q. Hu n & Z. Gu n

author keywords: biomaterials; cancer therapy; drug delivery; immune checkpoint blockade; immunotherapy
MeSH headings : Autoimmune Diseases / immunology; Autoimmune Diseases / therapy; Humans; Immunotherapy / methods; Neoplasms / immunology; Neoplasms / therapy
topics (OpenAlex): Cancer Immunotherapy and Biomarkers; Immune Cell Function and Interaction; Lung Cancer Research Studies
TL;DR: A brief review summarizes strategies to increase the antitumor immunity, including the local and targeted delivery of checkpoint inhibitors, and a combination of different checkpoint inhibitors or with other therapeutic treatments. (via Semantic Scholar)
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Added: November 19, 2018

2018 article

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

Zhang, X., Wang, J., Chen, Z., Hu, Q., Wang, C., Yan, J., … Gu, Z. (2018, July 31). Nano Letters.

By: X. Zhang n, J. Wang n, Z. Chen n, Q. Hu n, C. Wang  n, J. Yan  n, G. Dotti*, P. Huang *, Z. Gu n

author keywords: Drug delivery; platelet; immune checkpoint blockade; immunotherapy; nanomedicine
MeSH headings : Animals; Blood Platelets / immunology; Blood Platelets / metabolism; CD8-Positive T-Lymphocytes / immunology; Cell Line; Cyclophosphamide / administration & dosage; Cyclophosphamide / therapeutic use; Gene Expression; Genetic Engineering / methods; HEK293 Cells; Humans; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / therapeutic use; Immunotherapy / methods; Megakaryocyte Progenitor Cells / immunology; Megakaryocyte Progenitor Cells / metabolism; Melanoma / immunology; Melanoma / therapy; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology
topics (OpenAlex): Immunotherapy and Immune Responses; Phagocytosis and Immune Regulation; Cancer Immunotherapy and Biomarkers
TL;DR: This work genetically engineered platelets from megakaryocyte progenitor cells to express the programmed cell death protein 1 (PD-1) and found that the PD-1 platelet and its derived microparticle could accumulate within the tumor surgical wound and revert exhausted CD8+ T cells, leading to the eradication of residual tumor cells. (via Semantic Scholar)
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Added: October 16, 2018

2018 article

In situ formed reactive oxygen species–responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

Wang, C., Wang, J., Zhang, X., Yu, S., Wen, D., Hu, Q., … Gu, Z. (2018, February 21). Science Translational Medicine.

By: C. Wang  n, J. Wang n, X. Zhang n, S. Yu  n, D. Wen n, Q. Hu n, Y. Ye n, H. Bomba  n ...

MeSH headings : Animals; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine / analogs & derivatives; Deoxycytidine / therapeutic use; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Immunotherapy / methods; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / metabolism; Gemcitabine
topics (OpenAlex): Nanoplatforms for cancer theranostics; Immune cells in cancer; Nanoparticle-Based Drug Delivery
TL;DR: A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity and promotes an immune-mediated tumor regression in the tumor-bearing mice, with prevention of tumor recurrence after primary resection. (via Semantic Scholar)
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Added: August 6, 2018

2018 article

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

Chen, Q., Wang, C., Zhang, X., Chen, G., Hu, Q., Li, H., … Gu, Z. (2018, December 4). Nature Nanotechnology.

By: Q. Chen n, C. Wang  n, X. Zhang*, G. Chen*, Q. Hu n, H. Li*, J. Wang n, D. Wen* ...

MeSH headings : Animals; Biocompatible Materials / chemistry; Calcium Carbonate / chemistry; Female; Fibrin / chemistry; Gels / chemistry; Humans; Immunity; Immunotherapy / methods; Luminescent Measurements; Melanoma, Experimental / pathology; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Phagocytosis
topics (OpenAlex): Phagocytosis and Immune Regulation; Nanoplatforms for cancer theranostics; Immune cells in cancer
TL;DR: The findings indicate that the immunotherapeutic fibrin gel ‘awakens’ the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread. (via Semantic Scholar)
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Added: January 21, 2019

2018 article

Leveraging Engineering of Cells for Drug Delivery

Chen, Z., Hu, Q., & Gu, Z. (2018, February 15). Accounts of Chemical Research.

By: Z. Chen  n, Q. Hu n & Z. Gu n

MeSH headings : Animals; Cell Engineering; Drug Delivery Systems; Humans
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Nanoplatforms for cancer theranostics
TL;DR: This Account summarizes the recent contribution to the field of cell engineering methodologies and exploits a targeted checkpoint antibody delivery strategy for treatment of postsurgical cancer recurrence and metastatic spread by covalent binding of platelets' cell surfaces with a monoclonal antibody against programmed-death ligand 1. (via Semantic Scholar)
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Added: August 6, 2018

2018 article

PD‐1 Blockade Cellular Vesicles for Cancer Immunotherapy

Zhang, X., Wang, C., Wang, J., Hu, Q., Langworthy, B., Ye, Y., … Gu, Z. (2018, April 14). Advanced Materials.

By: X. Zhang n, C. Wang  n, J. Wang n, Q. Hu n, B. Langworthy *, Y. Ye  n, W. Sun  n, J. Lin * ...

author keywords: cancer immunotherapy; cell therapy; drug delivery; immune checkpoint blockade; nanomedicine
MeSH headings : Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Neoplasms / therapy; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tumor Microenvironment
topics (OpenAlex): Extracellular vesicles in disease; Nanoplatforms for cancer theranostics; Thermal properties of materials
TL;DR: E engineered cellular nanovesicles (NVs) presenting PD‐1 receptors on their membranes, which enhance antitumor responses by disrupting thePD‐1/PD‐L1 immune inhibitory axis, are reported. (via Semantic Scholar)
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Added: August 6, 2018

2018 article

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

Yan, J., Zhang, X., Liu, Y., Ye, Y., Yu, J., Chen, Q., … Gu, Z. (2018, December 13). Nano Research.

By: J. Yan  n, X. Zhang n, Y. Liu n, Y. Ye n, J. Yu n, Q. Chen n, J. Wang n, Y. Zhang n ...

author keywords: liquid metal; melanin nanoparticles; nanomedicine; shape-controlled synthesis; photothermal therapy
topics (OpenAlex): Gold and Silver Nanoparticles Synthesis and Applications; Extracellular vesicles in disease; Quantum Dots Synthesis And Properties
TL;DR: Interestingly, shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs, and among these shapes, EGaIn nanorice has the best photothermal conversion efficiency, which could be leveraged for photothermal therapy. (via Semantic Scholar)
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Added: June 17, 2019

2017 article

A melanin-mediated cancer immunotherapy patch

Ye, Y., Wang, C., Zhang, X., Hu, Q., Zhang, Y., Liu, Q., … Gu, Z. (2017, November 11). Science Immunology.

By: Y. Ye  n, C. Wang  n, X. Zhang n, Q. Hu n, Y. Zhang n, Q. Liu  n, D. Wen n, J. Milligan  n ...

MeSH headings : Animals; Cancer Vaccines / immunology; Cancer Vaccines / metabolism; Cell Line, Tumor; Dendritic Cells / immunology; Dendritic Cells / metabolism; Female; Immunotherapy / instrumentation; Immunotherapy / methods; Infrared Rays; Kaplan-Meier Estimate; Melanins / immunology; Melanins / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Needles; Neoplasms, Experimental / immunology; Neoplasms, Experimental / pathology; Neoplasms, Experimental / therapy; Transdermal Patch; Tumor Burden / immunology
topics (OpenAlex): Immunotherapy and Immune Responses; Nanoplatforms for cancer theranostics; Advancements in Transdermal Drug Delivery
TL;DR: It is found that the spatiotemporal photoresponsive immunotherapy increases infiltration of polarized T cells and local cytokine release in mice after tumor challenge and elicited antitumor effects toward established primary tumor and distant tumor. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Anaerobe‐Inspired Anticancer Nanovesicles

Qian, C., Feng, P., Yu, J., Chen, Y., Hu, Q., Sun, W., … Gu, Z. (2017, January 31). Angewandte Chemie International Edition.

By: C. Qian n, P. Feng *, J. Yu n, Y. Chen *, Q. Hu n, W. Sun n, X. Xiao*, X. Hu  n ...

author keywords: drug delivery; nanomedicines; photodynamic therapy
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Death / drug effects; Cell Proliferation / drug effects; Clostridium / chemistry; Clostridium / metabolism; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Hypoxia / metabolism; Imidazoles / chemistry; Imidazoles / pharmacology; Nanoparticles / chemistry; Prodrugs / chemistry; Prodrugs / pharmacology; Salmonella / chemistry; Salmonella / metabolism; Tirapazamine / chemistry; Tirapazamine / pharmacology
topics (OpenAlex): Nanoplatforms for cancer theranostics; Cancer Research and Treatments; Nanoparticle-Based Drug Delivery
TL;DR: An anaerobe nanovesicle mimic that can not only be activated in THRs but also induce hypoxia in tumors by themselves is presented and provides a new strategy for engineering stimuli-responsive drug delivery systems in a bioinspired and synergistic fashion. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Conjugated polymer nanomaterials for theranostics

Qian, C.-gen, Chen, Y.-lei, Feng, P.-jian, Xiao, X.-zhong, Dong, M., Yu, J.-cheng, … Gu, Z. (2017, May 29). Acta Pharmacologica Sinica.

By: C. Qian n, Y. Chen *, P. Feng *, X. Xiao*, M. Dong *, J. Yu n, Q. Hu n, Q. Shen *, Z. Gu n

author keywords: conjugated polymer; theranostics; biomedical imaging; photodynamic therapy; photothermal therapy; stimuli; responsive drug delivery
MeSH headings : Drug Delivery Systems; Nanostructures / chemistry; Photochemotherapy; Polymers / chemistry; Theranostic Nanomedicine
topics (OpenAlex): Nanoplatforms for cancer theranostics; Photoacoustic and Ultrasonic Imaging; Luminescence and Fluorescent Materials
TL;DR: This review highlights the recent advances in the utilization of CPNs in theranostics, and introduces CPN-based in vivo imaging techniques, including near-infrared (NIR), two-photon (TP) imaging, photoacoustic (PA), and multimodal (MM) imaging. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Engineering platelet-mimicking drug delivery vehicles

Hu, Q., Bomba, H. N., & Gu, Z. (2017, February 15). Frontiers of Chemical Science and Engineering.

By: Q. Hu n, H. Bomba  n & Z. Gu n

author keywords: drug delivery; platelets; nanomedicine; bio-inspired; biomimetic
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Electrospun Nanofibers in Biomedical Applications; Advanced Drug Delivery Systems
TL;DR: This review highlights recent advancements made in the platelet-mimicking strategies and discusses the future opportunities and translational challenges. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

Lu, Y., Lin, Y., Chen, Z., Hu, Q., Liu, Y., Yu, S., … Gu, Z. (2017, March 22). Nano Letters, Vol. 17, pp. 2138–2145.

By: Y. Lu n, Y. Lin n, Z. Chen n, Q. Hu n, Y. Liu  n, S. Yu  n, W. Gao n, M. Dickey n , Z. Gu n

author keywords: Drug delivery; liquid metal; stimuli-responsive; morphological transformation; endosomal escape
topics (OpenAlex): Advanced biosensing and bioanalysis techniques; Quantum Dots Synthesis And Properties; Plasmonic and Surface Plasmon Research
TL;DR: A light-fueled liquid-metal transformer for effective endosomal escape-facilitated cargo delivery via a chemical-mechanical process and equipped with graphene quantum dots provides a new strategy for facilitating effective endOSomal escape to achieve spatiotemporally controlled drug delivery with enhanced efficacy. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy

Hu, Q., Sun, W., Qian, C., Bomba, H. N., Xin, H., & Gu, Z. (2017, February 3). Advanced Materials.

By: Q. Hu n, W. Sun n, C. Qian n, H. Bomba n, H. Xin n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Nanoplatforms for cancer theranostics
TL;DR: A "relay drug delivery" system based on two distinct modules that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA is developed for amplifying active tumor targeting signal and enhancing antitumor therapy. (via Semantic Scholar)
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Added: August 6, 2018

2017 article

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Wang, C., Ye, Y., Hu, Q., Bellotti, A., & Gu, Z. (2017, May 26). Advanced Materials.

By: C. Wang n, Y. Ye n, Q. Hu n, A. Bellotti  n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; cell therapy; drug delivery
MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / metabolism; Antigens / genetics; Antigens / immunology; Antigens / metabolism; Biocompatible Materials / chemistry; Cell- and Tissue-Based Therapy; Humans; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Immunotherapy; Nanostructures / chemistry; Neoplasms / therapy
topics (OpenAlex): CAR-T cell therapy research; Immunotherapy and Immune Responses; Nanoplatforms for cancer theranostics
TL;DR: An overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune‐modulating scaffolds. (via Semantic Scholar)
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Added: August 6, 2018

2016 article

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

Qian, C., Chen, Y., Zhu, S., Yu, J., Zhang, L., Feng, P., … Gu, Z. (2016, January 1). Theranostics.

By: C. Qian n, Y. Chen *, S. Zhu *, J. Yu n, L. Zhang *, P. Feng *, X. Tang *, Q. Hu n ...

author keywords: drug delivery; nanomedicine; stimuli-responsive; ATP-responsive; theranostics; conjugated polymers
MeSH headings : Adenosine Triphosphate / metabolism; Antineoplastic Agents / administration & dosage; Boronic Acids / metabolism; Doxorubicin / administration & dosage; Drug Carriers / administration & dosage; Hep G2 Cells; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Nanoparticles / administration & dosage; Optical Imaging / methods; Theranostic Nanomedicine / methods
topics (OpenAlex): Nanoplatforms for cancer theranostics; Luminescence and Fluorescent Materials; Nanoparticle-Based Drug Delivery
TL;DR: In vivo studies validate that this adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging exhibits promising capability for inhibition of tumor growth. (via Semantic Scholar)
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Added: August 6, 2018

2016 conference paper

Cell membrane-mediated anticancer drug delivery

Nanotechnology: delivering on the promise, vol 2, 1224, 197–211.

By: Q. Hu & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2016 article

Dual targeted nanocarrier for brain ischemic stroke treatment

Zhao, Y., Jiang, Y., Lv, W., Wang, Z., Lv, L., Wang, B., … Gu, Z. (2016, May 1). Journal of Controlled Release.

By: Y. Zhao *, Y. Jiang *, W. Lv *, Z. Wang *, L. Lv *, B. Wang *, X. Liu *, Y. Liu * ...

author keywords: Stroke; Stroke homing peptide; Dual-targeting liposomes; ZL006; Neuroprotection
MeSH headings : Animals; Apoptosis / drug effects; Brain / drug effects; Brain / metabolism; Brain / pathology; Cell Line; Cell Line, Tumor; Collagen Type IV / administration & dosage; Collagen Type IV / chemistry; Collagen Type IV / therapeutic use; Drug Liberation; Glutamic Acid / pharmacology; Infarction, Middle Cerebral Artery / drug therapy; Infarction, Middle Cerebral Artery / metabolism; Infarction, Middle Cerebral Artery / pathology; Liposomes; Male; Mice, Inbred ICR; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Nanoparticles / therapeutic use; Neurons / drug effects; Neuroprotective Agents / administration & dosage; Neuroprotective Agents / chemistry; Neuroprotective Agents / therapeutic use; Peptide Fragments / administration & dosage; Peptide Fragments / chemistry; Peptide Fragments / therapeutic use; Polyethylene Glycols / chemistry; Rats, Sprague-Dawley; Stroke / drug therapy; Stroke / metabolism; Stroke / pathology
topics (OpenAlex): RNA Interference and Gene Delivery; Nanoparticle-Based Drug Delivery; Advanced biosensing and bioanalysis techniques
TL;DR: T7&SHp-P-LPs could be used as a safe and effective dual targeted nanocarrier for ischemic stroke treatment and could enhance the ability of in vivo anti-ischemic stroke of MCAO rats. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

Hu, Q., Qian, C., Sun, W., Wang, J., Chen, Z., Bomba, H. N., … Gu, Z. (2016, September 14). Advanced Materials.

By: Q. Hu n, C. Qian n, W. Sun n, J. Wang n, Z. Chen n, H. Bomba n, H. Xin n, Q. Shen *, Z. Gu n

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Biomimetics; Blood Platelets / cytology; Bone and Bones / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Cellular Microenvironment; Disease Models, Animal; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Humans; Mice; Multiple Myeloma / complications; Multiple Myeloma / drug therapy; Multiple Myeloma / metabolism; Multiple Myeloma / pathology; Nanoparticles / chemistry; Thrombosis / complications; Thrombosis / drug therapy
topics (OpenAlex): Multiple Myeloma Research and Treatments; Dendrimers and Hyperbranched Polymers; Protein Degradation and Inhibitors
TL;DR: A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and Myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myelomas growth and simultaneously eradicating thrombus complication. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

Lv, L., Jiang, Y., Liu, X., Wang, B., Lv, W., Zhao, Y., … Gu, Z. (2016, September 16). Molecular Pharmaceutics.

By: L. Lv *, Y. Jiang *, X. Liu *, B. Wang *, W. Lv *, Y. Zhao *, H. Shi *, Q. Hu n ...

author keywords: glioma; antineovasculature; dual-targeted nanoparticle; drug delivery; paclitaxel
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / chemistry; Antineoplastic Agents, Phytogenic / therapeutic use; Cell Line, Tumor; Drug Delivery Systems; Glioblastoma / drug therapy; Glioma / drug therapy; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles / chemistry; Paclitaxel / chemistry; Paclitaxel / therapeutic use; Polyesters / chemistry; Polyethylene Glycols / chemistry; Rats
topics (OpenAlex): Nanoplatforms for cancer theranostics; Nanoparticle-Based Drug Delivery; RNA Interference and Gene Delivery
TL;DR: The in vivo antiglioma efficacy and safety evaluation showed PC-NP-PTX significantly enhanced the antIGlioma effectiveness and displayed negligible acute toxicity. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Light‐Activated Hypoxia‐Responsive Nanocarriers for Enhanced Anticancer Therapy

Qian, C., Yu, J., Chen, Y., Hu, Q., Xiao, X., Sun, W., … Gu, Z. (2016, March 7). Advanced Materials.

By: C. Qian n, J. Yu n, Y. Chen *, Q. Hu n, X. Xiao*, W. Sun n, C. Wang n, P. Feng *, Q. Shen *, Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Hypoxia; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Drug Carriers / chemistry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Light; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Neoplasms / diagnostic imaging; Neoplasms / drug therapy; Neoplasms / pathology; Optical Imaging; Polyvinyl Alcohol / chemistry; Singlet Oxygen / chemistry; Singlet Oxygen / metabolism; Transplantation, Heterologous
topics (OpenAlex): Nanoplatforms for cancer theranostics; Luminescence and Fluorescent Materials; Photodynamic Therapy Research Studies
TL;DR: A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen and inducing hypoxide to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

Shi, D., Xu, X., Ye, Y., Song, K., Cheng, Y., Di, J., … Gu, Z. (2016, January 12). ACS Nano.

By: D. Shi *, X. Xu *, Y. Ye n, K. Song *, Y. Cheng, J. Di n, Q. Hu n, J. Li ...

author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Proteoglycans and glycosaminoglycans research; Silk-based biomaterials and applications
TL;DR: The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology makes the chondrogenesis efficient and persistent. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

Sun, W., Ji, W., Hu, Q., Yu, J., Wang, C., Qian, C., … Gu, Z. (2016, April 29). Biomaterials.

By: W. Sun n, W. Ji  n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
MeSH headings : Cell Death / drug effects; Cell Line, Tumor; Cell Membrane / metabolism; Cytokines / administration & dosage; DNA / metabolism; Drug Carriers / chemistry; Drug Delivery Systems; Humans; Hydrodynamics; Liposomes; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Nickel / chemistry; Particle Size; Phosphatidylcholines / chemistry; Phospholipases A2 / metabolism; TNF-Related Apoptosis-Inducing Ligand / pharmacology
topics (OpenAlex): RNA Interference and Gene Delivery; Advanced biosensing and bioanalysis techniques; Dendrimers and Hyperbranched Polymers
TL;DR: A tumor microenvironment-responsive and transformable nanocarrier for cell membrane targeted delivery of cytokine using a phospholipase A2 degradable liposome as a shell and complementary DNA nanostructures decorated with cytokines as the cores is reported. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

Hu, Q., Sun, W., Lu, Y., Bomba, H. N., Ye, Y., Jiang, T., … Gu, Z. (2016, January 19). Nano Letters.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang *, A. Isaacson *, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
topics (OpenAlex): Nanoplatforms for cancer theranostics; Nanoparticle-Based Drug Delivery; RNA Interference and Gene Delivery
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Anticancer Platelet‐Mimicking Nanovehicles

Hu, Q., Sun, W., Qian, C., Wang, C., Bomba, H. N., & Gu, Z. (2015, September 29). Advanced Materials.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
topics (OpenAlex): Extracellular vesicles in disease; Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics
TL;DR: A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Recent advances of cocktail chemotherapy by combination drug delivery systems

Hu, Q., Sun, W., Wang, C., & Gu, Z. (2015, November 6). Advanced Drug Delivery Reviews.

By: Q. Hu n, W. Sun n, C. Wang n & Z. Gu n

author keywords: Chemotherapy; Combination; Cancer; Nanocarriers; Drug delivery
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Drug Delivery Systems; Humans; Nanoparticles / administration & dosage; Nanoparticles / therapeutic use; Neoplasms / drug therapy
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Graphene and Nanomaterials Applications; Advanced biosensing and bioanalysis techniques
TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

Angewandte Chemie International Edition, 54(41), 12029–12033.

By: W. Sun n, W. Ji  n, J. Hall n, Q. Hu n, C. Wang  n, C. Beisel n, Z. Gu n

author keywords: CRISPR-Cas9; DNA; drug delivery; genome editing; nanoparticles
MeSH headings : Animals; CRISPR-Associated Proteins / administration & dosage; CRISPR-Associated Proteins / chemistry; CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / administration & dosage; DNA / chemistry; DNA / genetics; Green Fluorescent Proteins / genetics; Humans; Mice, Nude; Nanoparticles / chemistry; Neoplasms / genetics; Neoplasms / therapy; RNA, Guide, Kinetoplastida / administration & dosage; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Streptococcus pyogenes / chemistry; Streptococcus pyogenes / genetics
topics (OpenAlex): CRISPR and Genetic Engineering; Advanced biosensing and bioanalysis techniques; RNA Interference and Gene Delivery
TL;DR: The biologically inspired vehicles were efficiently loaded with Cas9/sgRNA complexes and delivered the complexes to the nuclei of human cells, thus enabling targeted gene disruption while maintaining cell viability. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Spatiotemporal drug delivery using laser-generated-focused ultrasound system

Journal of Controlled Release, 220, 592–599.

By: J. Di n, J. Kim n, Q. Hu n, X. Jiang n  & Z. Gu n

Contributors: J. Di n, J. Kim n, Q. Hu n, X. Jiang n  & Z. Gu n

author keywords: Drug delivery; Photoacoustic; Nanoparticles; Microgels; Stimuli responsive
MeSH headings : Alginates / chemistry; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Chemistry, Pharmaceutical; Ciprofloxacin / administration & dosage; Ciprofloxacin / chemistry; Delayed-Action Preparations; Dimethylpolysiloxanes / chemistry; Disk Diffusion Antimicrobial Tests; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers; Equipment Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Gels; Glucuronic Acid / chemistry; HeLa Cells; Hexuronic Acids / chemistry; Humans; Kinetics; Lactic Acid / chemistry; Lasers; Nanoparticles; Photoacoustic Techniques; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Soot / chemistry; Spheroids, Cellular; Technology, Pharmaceutical / instrumentation; Technology, Pharmaceutical / methods; Transducers; Ultrasonic Waves; Ultrasonics / instrumentation; Ultrasonics / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Nanoplatforms for cancer theranostics; Photoacoustic and Ultrasonic Imaging
TL;DR: This novel LGFU-responsive drug delivery system provides a simple and remote approach to precisely control the release of therapeutics in a spatiotemporal manner and potentially suppress detrimental effects to the surrounding tissue, such as thermal ablation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2015 article

Transformable liquid-metal nanomedicine

Lu, Y., Hu, Q., Lin, Y., Pacardo, D. B., Wang, C., Sun, W., … Gu, Z. (2015, December 2). Nature Communications, Vol. 6.

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey n , Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Nanoplatforms for cancer theranostics; Nanowire Synthesis and Applications
TL;DR: A transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell, providing a new strategy for engineering theranostic agents with low toxicity. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 article

Enzyme-responsive nanomaterials for controlled drug delivery

Hu, Q., Katti, P. S., & Gu, Z. (2014, September 24). Nanoscale.

By: Q. Hu n, P. Katti* & Z. Gu n

MeSH headings : Animals; Apoptosis; Biotechnology; Drug Delivery Systems; Enzymes / chemistry; Humans; Inorganic Chemicals / chemistry; Liposomes / chemistry; Metal Nanoparticles / chemistry; Mice; Nanostructures / chemistry; Nanotechnology; Oxidoreductases / chemistry; Peptide Hydrolases / chemistry; Phospholipases / chemistry
topics (OpenAlex): Nanoparticle-Based Drug Delivery; Advanced Nanomaterials in Catalysis; Graphene and Nanomaterials Applications
TL;DR: This review describes enzymes such as proteases, phospholipases and oxidoreductases that serve as delivery triggers and explores recently developed enzyme-responsive nanomaterials with versatile applications for extracellular and intracellular drug delivery. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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