Works (38)

Updated: July 20th, 2023 21:13

2022 journal article

Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy

NATIONAL SCIENCE REVIEW, 9(3).

By: H. Li*, Z. Wang*, E. Archibong, Q. Wu*, G. Chen*, Q. Hu n, T. Ci*, Z. Chen* ...

author keywords: drug delivery; CAR T therapy; microneedle patch; solid tumor treatment; cell delivery
TL;DR: A porous microneedle patch is implemented that accommodates CAR T cells and allows in situ penetration-mediated seeding ofCAR T cells when implanted in the tumor bed or in the post-surgical resection cavity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 28, 2022

2021 article

Inhibition of post-surgery tumour recurrence via a hydrogel releasing CAR-T cells and anti-PDL1-conjugated platelets

Hu, Q., Li, H., Archibong, E., Chen, Q., Ruan, H., Ahn, S., … Gu, Z. (2021, April 26). NATURE BIOMEDICAL ENGINEERING.

By: Q. Hu*, H. Li*, E. Archibong n, Q. Chen*, H. Ruan*, S. Ahn*, E. Dukhovlinova*, Y. Kang* ...

MeSH headings : Animals; Antibodies, Monoclonal, Humanized; Blood Platelets; Cell-Derived Microparticles; Hydrogels; Immunotherapy, Adoptive; Mice; Neoplasm Recurrence, Local / prevention & control; T-Lymphocytes; Tumor Microenvironment
TL;DR: A hydrogel implanted into the cavity of a resected tumour and releasing CAR-T cells and platelets conjugated with a checkpoint inhibitor inhibits local tumour recurrence and the growth of distant tumours in mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2020 journal article

CRISPR-Cas12a delivery by DNA-mediated bioresponsive editing for cholesterol regulation

SCIENCE ADVANCES, 6(21).

MeSH headings : CRISPR-Cas Systems; Cholesterol; DNA / genetics; DNA / metabolism; Gene Editing; Polymers / metabolism; Proprotein Convertase 9 / genetics; Proprotein Convertase 9 / metabolism; RNA / genetics; Ribonucleoproteins / genetics
TL;DR: A DNA nanoclew (NC)-based carrier for delivery of Cas12a/CRISPR RNA (crRNA) ribonucleoprotein (R NP) toward regulating serum cholesterol levels and significantly reducing the expression of PCSK9 and gaining the therapeutic benefit of cholesterol control. (via Semantic Scholar)
Source: Web Of Science
Added: June 22, 2020

2019 journal article

A Dual-Bioresponsive Drug-Delivery Depot for Combination of Epigenetic Modulation and Immune Checkpoint Blockade

ADVANCED MATERIALS, 31(17).

author keywords: bioresponsive materials; drug delivery; epigenetic modulation; immune checkpoint blockade; immunotherapy
MeSH headings : Animals; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Calcium Carbonate / chemistry; Cell Line, Tumor; Cytidine / analogs & derivatives; Cytidine / pharmacology; Drug Delivery Systems / methods; Drug Liberation; Drug Therapy, Combination / methods; Humans; Hydrogen-Ion Concentration; Immunosuppressive Agents / chemistry; Immunosuppressive Agents / pharmacology; Immunotherapy / methods; Melanoma / drug therapy; Nanoparticles / chemistry; Programmed Cell Death 1 Receptor / metabolism; Reactive Oxygen Species / metabolism; Tumor Microenvironment / drug effects
TL;DR: It is demonstrated that this combination therapy increases the immunogenicity of cancer cells, and also plays roles in reversing immunosuppressive TME, which contributes to inhibiting the tumor growth and prolonging the survival time of B16F10‐melanoma‐bearing mice. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: May 13, 2019

2019 journal article

A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth

ACS NANO, 13(4), 4354–4360.

By: G. Yang n, Q. Chen n, D. Wen n, Z. Chen n, J. Wang n, G. Chen n, Z. Wang*, X. Zhang n ...

author keywords: drug delivery; microneedle; exosome; keratin; hair regrowth; transdermal drug delivery
MeSH headings : Animals; Cell Line; Delayed-Action Preparations / chemistry; Drug Delivery Systems / instrumentation; Equipment Design; Hair / chemistry; Hair / drug effects; Hair / growth & development; Hair Follicle / drug effects; Hair Follicle / growth & development; Humans; Injections, Subcutaneous; Keratins / chemistry; Mice, Inbred C57BL; Transdermal Patch
TL;DR: It was demonstrated that this microneedle device integrated with mesenchymal stem cell (MSC)-derived exosomes and a small molecular drug, UK5099, could enhance the treatment efficiency at a reduced dosage, leading to promoted pigmentation and hair regrowth within 6 days through two rounds of administration in a mouse model. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 4, 2019

2019 journal article

Adipocytes as Anticancer Drug Delivery Depot

MATTER, 1(5), 1203–1214.

By: D. Wen n, J. Wang n, G. Van Den Driessche n, Q. Chen n, Y. Zhang n, G. Chen n, H. Li*, J. Soto* ...

TL;DR: The lipid metabolism is exploited to engineer adipocytes that serve as a depot to deliver cancer therapeutics at the tumor site, promoting antitumor efficacy and downregulation of PD-L1 expression is observed in tumor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 6, 2020

2019 journal article

In situ sprayed bioresponsive immunotherapeutic gel for post-surgical cancer treatment

NATURE NANOTECHNOLOGY, 14(1), 89-+.

By: Q. Chen n, C. Wang n, X. Zhang*, G. Chen*, Q. Hu n, H. Li*, J. Wang n, D. Wen* ...

MeSH headings : Animals; Biocompatible Materials / chemistry; Calcium Carbonate / chemistry; Female; Fibrin / chemistry; Gels / chemistry; Humans; Immunity; Immunotherapy / methods; Luminescent Measurements; Melanoma, Experimental / pathology; Mice, Inbred C57BL; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasm Recurrence, Local / pathology; Neoplasms / pathology; Neoplasms / surgery; Phagocytosis
TL;DR: The findings indicate that the immunotherapeutic fibrin gel ‘awakens’ the host innate and adaptive immune systems to inhibit both local tumour recurrence post surgery and potential metastatic spread. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 21, 2019

2019 journal article

Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells

ADVANCED MATERIALS, 31(23).

By: Q. Chen n, Q. Hu n, E. Dukhovlinova*, G. Chen*, S. Ahn*, C. Wang n, E. Ogunnaike n, F. Ligler n, G. Dotti*, Z. Gu n

author keywords: CAR T cells; cell therapy; drug delivery; immunotherapy; photothermal therapy
MeSH headings : Animals; Antigens / metabolism; Cell Line, Tumor; Chondroitin Sulfate Proteoglycans / metabolism; Combined Modality Therapy; Female; Heterografts; Humans; Hyperthermia, Induced; Immunotherapy, Adoptive / methods; Indocyanine Green / chemistry; Melanoma / pathology; Melanoma / therapy; Membrane Proteins / metabolism; Mice, SCID; Nanoparticles / chemistry; Photosensitizing Agents / chemistry; Phototherapy / methods; Polylactic Acid-Polyglycolic Acid Copolymer / chemistry; Proteoglycans / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / therapy; T-Lymphocytes / metabolism; T-Lymphocytes / transplantation; Tumor Microenvironment
TL;DR: It is found that the chondroitin sulfate proteoglycan‐4 (CSPG4)‐specific CAR T cells infused in Nod scid gamma mice engrafted with the human melanoma WM115 cell line have superior antitumor activity after photothermal ablation of the tumor. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: July 22, 2019

2019 journal article

Shape-controlled synthesis of liquid metal nanodroplets for photothermal therapy

NANO RESEARCH, 12(6), 1313–1320.

By: J. Yan n, X. Zhang n, Y. Liu n, Y. Ye n, J. Yu n, Q. Chen n, J. Wang n, Y. Zhang n ...

author keywords: liquid metal; melanin nanoparticles; nanomedicine; shape-controlled synthesis; photothermal therapy
TL;DR: Interestingly, shape-controlled synthesis of LM nanodroplets can be achieved by the incorporation of MNPs, and among these shapes, EGaIn nanorice has the best photothermal conversion efficiency, which could be leveraged for photothermal therapy. (via Semantic Scholar)
Source: Web Of Science
Added: June 17, 2019

2018 journal article

Advances in transformable drug delivery systems

BIOMATERIALS, 178, 546–558.

By: Q. Hu n, Q. Chen n & Z. Gu n

author keywords: Drug delivery; Stimuli-responsive; Cancer therapy; Transformable formulation
MeSH headings : Animals; Drug Delivery Systems / methods; Extracellular Space / chemistry; Humans; Intracellular Space / chemistry; Microbubbles; Nanoparticles / chemistry; Nanoparticles / ultrastructure; Neoplasms / diagnosis; Neoplasms / pathology
TL;DR: This review describes the recently developed intracelluarly and extracellularly transformable DDSs, especially associated with assembly or disassociation of the original formulation units, for achieving various functionalities, including prolonged retention time, inhibited endocytosis and enhanced cytotoxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 19, 2018

2018 journal article

Conjugation of haematopoietic stem cells and platelets decorated with anti-PD-1 antibodies augments anti-leukaemia efficacy

NATURE BIOMEDICAL ENGINEERING, 2(11), 831–840.

By: Q. Hu*, W. Sun*, J. Wang*, H. Ruan*, X. Zhang*, Y. Ye n, S. Shen*, C. Wang n ...

MeSH headings : Animals; Antibodies / chemistry; Antibodies / immunology; Blood Platelets / chemistry; Blood Platelets / cytology; Blood Platelets / metabolism; Cell Line, Tumor; Chemokines / metabolism; Cytokines / metabolism; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells / chemistry; Hematopoietic Stem Cells / cytology; Hematopoietic Stem Cells / metabolism; Leukemia / therapy; Mice; Mice, Inbred C57BL; Mice, Knockout; Programmed Cell Death 1 Receptor / deficiency; Programmed Cell Death 1 Receptor / genetics; Programmed Cell Death 1 Receptor / immunology; T-Lymphocytes / cytology; T-Lymphocytes / immunology; T-Lymphocytes / metabolism
TL;DR: It is shown that systemically delivered blood platelets decorated with anti-PD-1 antibodies and conjugated to haematopoietic stem cells reduce the growth and recurrence of leukaemia in mice and significantly augment the therapeutic efficacy of checkpoint blockade. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 26, 2018

2018 journal article

Delivery Strategies for Immune Checkpoint Blockade

ADVANCED HEALTHCARE MATERIALS, 7(20).

By: Q. Chen n, C. Wang n, G. Chen n, Q. Hu n & Z. Gu n

author keywords: biomaterials; cancer therapy; drug delivery; immune checkpoint blockade; immunotherapy
MeSH headings : Autoimmune Diseases / immunology; Autoimmune Diseases / therapy; Humans; Immunotherapy / methods; Neoplasms / immunology; Neoplasms / therapy
TL;DR: A brief review summarizes strategies to increase the antitumor immunity, including the local and targeted delivery of checkpoint inhibitors, and a combination of different checkpoint inhibitors or with other therapeutic treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 19, 2018

2018 journal article

Engineering PD-1-Presenting Platelets for Cancer Immunotherapy

NANO LETTERS, 18(9), 5716–5725.

By: X. Zhang n, J. Wang n, Z. Chen n, Q. Hu n, C. Wang n, J. Yan n, G. Dotti*, P. Huang*, Z. Gu n

author keywords: Drug delivery; platelet; immune checkpoint blockade; immunotherapy; nanomedicine
TL;DR: This work genetically engineered platelets from megakaryocyte progenitor cells to express the programmed cell death protein 1 (PD-1) and found that the PD-1 platelet and its derived microparticle could accumulate within the tumor surgical wound and revert exhausted CD8+ T cells, leading to the eradication of residual tumor cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 16, 2018

2018 journal article

In situ formed reactive oxygen species-responsive scaffold with gemcitabine and checkpoint inhibitor for combination therapy

SCIENCE TRANSLATIONAL MEDICINE, 10(429).

By: C. Wang n, J. Wang n, X. Zhang n, S. Yu n, D. Wen n, Q. Hu n, Y. Ye n, H. Bomba n ...

MeSH headings : Animals; Cell Line, Tumor; Combined Modality Therapy; Deoxycytidine / analogs & derivatives; Deoxycytidine / therapeutic use; Female; Hydrogel, Polyethylene Glycol Dimethacrylate / chemistry; Immunotherapy / methods; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor / metabolism; Gemcitabine
TL;DR: A ROS-responsive hydrogel scaffold controls release of gemcitabine and immune checkpoint inhibitor for enhanced antitumor activity and promotes an immune-mediated tumor regression in the tumor-bearing mice, with prevention of tumor recurrence after primary resection. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2018 review

Leveraging Engineering of Cells for Drug Delivery

[Review of ]. ACCOUNTS OF CHEMICAL RESEARCH, 51(3), 668–677.

By: Z. Chen n, Q. Hu n & Z. Gu n

MeSH headings : Animals; Cell Engineering; Drug Delivery Systems; Humans
TL;DR: This Account summarizes the recent contribution to the field of cell engineering methodologies and exploits a targeted checkpoint antibody delivery strategy for treatment of postsurgical cancer recurrence and metastatic spread by covalent binding of platelets' cell surfaces with a monoclonal antibody against programmed-death ligand 1. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2018 journal article

PD-1 Blockade Cellular Vesicles for Cancer Immunotherapy

ADVANCED MATERIALS, 30(22).

By: X. Zhang n, C. Wang n, J. Wang n, Q. Hu n, B. Langworthy*, Y. Ye n, W. Sun n, J. Lin* ...

author keywords: cancer immunotherapy; cell therapy; drug delivery; immune checkpoint blockade; nanomedicine
MeSH headings : Humans; Immunotherapy; Lymphocytes, Tumor-Infiltrating; Neoplasms / therapy; Programmed Cell Death 1 Receptor; T-Lymphocytes; Tumor Microenvironment
TL;DR: E engineered cellular nanovesicles (NVs) presenting PD‐1 receptors on their membranes, which enhance antitumor responses by disrupting thePD‐1/PD‐L1 immune inhibitory axis, are reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

A melanin-mediated cancer immunotherapy patch

SCIENCE IMMUNOLOGY, 2(17).

By: Y. Ye n, C. Wang n, X. Zhang n, Q. Hu n, Y. Zhang n, Q. Liu n, D. Wen n, J. Milligan n ...

MeSH headings : Animals; Cancer Vaccines / immunology; Cancer Vaccines / metabolism; Cell Line, Tumor; Dendritic Cells / immunology; Dendritic Cells / metabolism; Female; Immunotherapy / instrumentation; Immunotherapy / methods; Infrared Rays; Kaplan-Meier Estimate; Melanins / immunology; Melanins / metabolism; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Needles; Neoplasms, Experimental / immunology; Neoplasms, Experimental / pathology; Neoplasms, Experimental / therapy; Transdermal Patch; Tumor Burden / immunology
TL;DR: It is found that the spatiotemporal photoresponsive immunotherapy increases infiltration of polarized T cells and local cytokine release in mice after tumor challenge and elicited antitumor effects toward established primary tumor and distant tumor. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Anaerobe-Inspired Anticancer Nanovesicles

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(10), 2588–2593.

By: C. Qian n, P. Feng*, J. Yu n, Y. Chen*, Q. Hu n, W. Sun n, X. Xiao*, X. Hu n ...

author keywords: drug delivery; nanomedicines; photodynamic therapy
MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Cell Death / drug effects; Cell Proliferation / drug effects; Clostridium / chemistry; Clostridium / metabolism; Drug Carriers / chemistry; Drug Carriers / metabolism; Drug Delivery Systems; Drug Screening Assays, Antitumor; Humans; Hypoxia / metabolism; Imidazoles / chemistry; Imidazoles / pharmacology; Nanoparticles / chemistry; Prodrugs / chemistry; Prodrugs / pharmacology; Salmonella / chemistry; Salmonella / metabolism; Tirapazamine / chemistry; Tirapazamine / pharmacology
TL;DR: An anaerobe nanovesicle mimic that can not only be activated in THRs but also induce hypoxia in tumors by themselves is presented and provides a new strategy for engineering stimuli-responsive drug delivery systems in a bioinspired and synergistic fashion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 review

Conjugated polymer nanomaterials for theranostics

[Review of ]. ACTA PHARMACOLOGICA SINICA, 38(6), 764–781.

By: Q. Cheng-gen*, Y. Chen*, P. Feng*, X. Xiao*, M. Dong*, J. Yu n, Q. Hu n, Q. Shen*, Z. Gu n

author keywords: conjugated polymer; theranostics; biomedical imaging; photodynamic therapy; photothermal therapy; stimuli; responsive drug delivery
MeSH headings : Drug Delivery Systems; Nanostructures / chemistry; Photochemotherapy; Polymers / chemistry; Theranostic Nanomedicine
TL;DR: This review highlights the recent advances in the utilization of CPNs in theranostics, and introduces CPN-based in vivo imaging techniques, including near-infrared (NIR), two-photon (TP) imaging, photoacoustic (PA), and multimodal (MM) imaging. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2017 review

Engineering platelet-mimicking drug delivery vehicles

[Review of ]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING, 11(4), 624–632.

By: Q. Hu n, H. Bomba n & Z. Gu n

author keywords: drug delivery; platelets; nanomedicine; bio-inspired; biomimetic
TL;DR: This review highlights recent advancements made in the platelet-mimicking strategies and discusses the future opportunities and translational challenges. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Enhanced Endosomal Escape by Light-Fueled Liquid-Metal Transformer

NANO LETTERS, 17(4), 2138–2145.

By: Y. Lu n, Y. Lin n, Z. Chen n, Q. Hu n, Y. Liu n, S. Yu n, W. Gao n, M. Dickey n, Z. Gu n

author keywords: Drug delivery; liquid metal; stimuli-responsive; morphological transformation; endosomal escape
TL;DR: A light-fueled liquid-metal transformer for effective endosomal escape-facilitated cargo delivery via a chemical-mechanical process and equipped with graphene quantum dots provides a new strategy for facilitating effective endOSomal escape to achieve spatiotemporally controlled drug delivery with enhanced efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Relay Drug Delivery for Amplifying Targeting Signal and Enhancing Anticancer Efficacy

ADVANCED MATERIALS, 29(13).

By: Q. Hu n, W. Sun n, C. Qian n, H. Bomba n, H. Xin n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Biomimetic Materials / chemistry; Blood Vessels / drug effects; Blood Vessels / metabolism; Cell Line, Tumor; Cell Survival / drug effects; Cells, Cultured; Dextrans / chemistry; Drug Delivery Systems; Human Umbilical Vein Endothelial Cells / drug effects; Human Umbilical Vein Endothelial Cells / metabolism; Humans; Mice, Nude; Microtubules / enzymology; Microtubules / metabolism; Nanostructures / chemistry; Neoplasm Transplantation; Neoplasms / blood supply; Neoplasms / drug therapy; Neoplasms / metabolism; Oligopeptides / chemistry; Paclitaxel / administration & dosage; Paclitaxel / pharmacokinetics; Tumor Necrosis Factor-alpha / chemistry; Tumor Necrosis Factor-alpha / pharmacokinetics
TL;DR: A "relay drug delivery" system based on two distinct modules that can specifically induce tumor blood vessel inflammation generation and an execution biomimetic nanocarrier B that can accumulate at the tumor site by receiving the broadcasting signals generated by NCA is developed for amplifying active tumor targeting signal and enhancing antitumor therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

ADVANCED MATERIALS, 29(29).

By: C. Wang n, Y. Ye n, Q. Hu n, A. Bellotti n & Z. Gu n

author keywords: biomaterials; cancer immunotherapy; cell therapy; drug delivery
MeSH headings : Animals; Antigen-Presenting Cells / cytology; Antigen-Presenting Cells / metabolism; Antigens / genetics; Antigens / immunology; Antigens / metabolism; Biocompatible Materials / chemistry; Cell- and Tissue-Based Therapy; Humans; Immunologic Factors / metabolism; Immunologic Factors / therapeutic use; Immunotherapy; Nanostructures / chemistry; Neoplasms / therapy
TL;DR: An overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune‐modulating scaffolds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

ATP-Responsive and Near-Infrared-Emissive Nanocarriers for Anticancer Drug Delivery and Real-Time Imaging

THERANOSTICS, 6(7), 1053–1064.

By: C. Qian n, Y. Chen, S. Zhu*, J. Yu n, L. Zhang*, P. Feng*, X. Tang*, Q. Hu n ...

author keywords: drug delivery; nanomedicine; stimuli-responsive; ATP-responsive; theranostics; conjugated polymers
MeSH headings : Adenosine Triphosphate / metabolism; Antineoplastic Agents / administration & dosage; Boronic Acids / metabolism; Doxorubicin / administration & dosage; Drug Carriers / administration & dosage; Hep G2 Cells; Humans; Liver Neoplasms / diagnostic imaging; Liver Neoplasms / drug therapy; Nanoparticles / administration & dosage; Optical Imaging / methods; Theranostic Nanomedicine / methods
TL;DR: In vivo studies validate that this adenosine-5'-triphosphate (ATP)-responsive and near-infrared (NIR)-emissive conjugated polymer-based nanocarrier for the controlled release of anticancer drugs and real-time imaging exhibits promising capability for inhibition of tumor growth. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 conference paper

Cell membrane-mediated anticancer drug delivery

Nanotechnology: delivering on the promise, vol 2, 1224, 197–211.

By: Q. Hu & Z. Gu

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Dual targeted nanocarrier for brain ischemic stroke treatment

JOURNAL OF CONTROLLED RELEASE, 233, 64–71.

By: Y. Zhao*, Y. Jiang*, W. Lv*, Z. Wang*, L. Lv*, B. Wang*, X. Liu*, Y. Liu* ...

author keywords: Stroke; Stroke homing peptide; Dual-targeting liposomes; ZL006; Neuroprotection
TL;DR: T7&SHp-P-LPs could be used as a safe and effective dual targeted nanocarrier for ischemic stroke treatment and could enhance the ability of in vivo anti-ischemic stroke of MCAO rats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Engineered Nanoplatelets for Enhanced Treatment of Multiple Myeloma and Thrombus

ADVANCED MATERIALS, 28(43), 9573-+.

By: Q. Hu n, C. Qian n, W. Sun n, J. Wang n, Z. Chen n, H. Bomba n, H. Xin n, Q. Shen*, Z. Gu n

MeSH headings : Animals; Biomimetic Materials / chemistry; Biomimetic Materials / pharmacokinetics; Biomimetics; Blood Platelets / cytology; Bone and Bones / metabolism; Cell Line, Tumor; Cell Membrane / metabolism; Cellular Microenvironment; Disease Models, Animal; Drug Carriers / chemistry; Drug Carriers / pharmacokinetics; Humans; Mice; Multiple Myeloma / complications; Multiple Myeloma / drug therapy; Multiple Myeloma / metabolism; Multiple Myeloma / pathology; Nanoparticles / chemistry; Thrombosis / complications; Thrombosis / drug therapy
TL;DR: A platelet-membrane-coated biomimetic nanocarrier, which can sequentially target the bone microenvironment and Myeloma cells to enhance the drug availability at the myeloma site and decrease off-target effects, is developed for inhibiting multiple myelomas growth and simultaneously eradicating thrombus complication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Enhanced Antiglioblastoma Efficacy of Neovasculature and Glioma Cells Dual Targeted Nanoparticles

MOLECULAR PHARMACEUTICS, 13(10), 3506–3517.

By: L. Lv*, Y. Jiang*, X. Liu*, B. Wang*, W. Lv*, Y. Zhao*, H. Shi*, Q. Hu n ...

author keywords: glioma; antineovasculature; dual-targeted nanoparticle; drug delivery; paclitaxel
MeSH headings : Animals; Antineoplastic Agents, Phytogenic / chemistry; Antineoplastic Agents, Phytogenic / therapeutic use; Cell Line, Tumor; Drug Delivery Systems; Glioblastoma / drug therapy; Glioma / drug therapy; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Nanoparticles / chemistry; Paclitaxel / chemistry; Paclitaxel / therapeutic use; Polyesters / chemistry; Polyethylene Glycols / chemistry; Rats
TL;DR: The in vivo antiglioma efficacy and safety evaluation showed PC-NP-PTX significantly enhanced the antIGlioma effectiveness and displayed negligible acute toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Light-Activated Hypoxia-Responsive Nanocarriers for Enhanced Anticancer Therapy

ADVANCED MATERIALS, 28(17), 3313–3320.

By: C. Qian n, J. Yu n, Y. Chen*, Q. Hu n, X. Xiao*, W. Sun n, C. Wang n, P. Feng*, Q. Shen*, Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Cell Hypoxia; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Doxorubicin / therapeutic use; Drug Carriers / chemistry; HeLa Cells; Humans; Hydrogen-Ion Concentration; Light; Mice; Mice, Nude; Microscopy, Confocal; Microscopy, Electron, Transmission; Nanoparticles / chemistry; Neoplasms / diagnostic imaging; Neoplasms / drug therapy; Neoplasms / pathology; Optical Imaging; Polyvinyl Alcohol / chemistry; Singlet Oxygen / chemistry; Singlet Oxygen / metabolism; Transplantation, Heterologous
TL;DR: A light-activated hypoxia-responsive conjugated polymer-based nanocarrier is developed for efficiently producing singlet oxygen and inducing hypoxide to promote release of its cargoes in tumor cells, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Photo-Cross-Linked Scaffold with Kartogenin-Encapsulated Nanoparticles for Cartilage Regeneration

ACS NANO, 10(1), 1292–1299.

By: D. Shi*, X. Xu*, Y. Ye n, K. Song*, Y. Cheng, J. Di n, Q. Hu n, J. Li ...

author keywords: drug delivery; tissue engineering; hydrogel; regenerative medicine; nanoparticles
TL;DR: The effect of an ultraviolet-reactive, rapidly cross-linkable scaffold integrated with kartogenin-loaded nanoparticles using an innovational one-step technology makes the chondrogenesis efficient and persistent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 review

Recent advances of cocktail chemotherapy by combination drug delivery systems

[Review of ]. ADVANCED DRUG DELIVERY REVIEWS, 98, 19–34.

By: Q. Hu n, W. Sun n, C. Wang n & Z. Gu n

author keywords: Chemotherapy; Combination; Cancer; Nanocarriers; Drug delivery
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Drug Delivery Systems; Humans; Nanoparticles / administration & dosage; Nanoparticles / therapeutic use; Neoplasms / drug therapy
TL;DR: This review surveys the most recent advances in combination delivery of multiple small molecule chemotherapeutics using nanocarriers and highlights the sequential and site-specific co-delivery strategies, which provide new guidelines for development of programmable combination drug delivery systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Transformable DNA nanocarriers for plasma membrane targeted delivery of cytokine

BIOMATERIALS, 96, 1–10.

By: W. Sun n, W. Ji n, Q. Hu n, J. Yu n, C. Wang n, C. Qian n, G. Hochu n, Z. Gu n

author keywords: Cancer; Protein delivery; DNA structures; Cytokine; Nanomedicine
TL;DR: A tumor microenvironment-responsive and transformable nanocarrier for cell membrane targeted delivery of cytokine using a phospholipase A2 degradable liposome as a shell and complementary DNA nanostructures decorated with cytokines as the cores is reported. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

NANO LETTERS, 16(2), 1118–1126.

By: Q. Hu n, W. Sun n, Y. Lu n, H. Bomba n, Y. Ye n, T. Jiang*, A. Isaacson*, Z. Gu n

author keywords: Drug delivery; stimuli-responsive; tumor microenvironment; apoptosis; antiangiogenesis
MeSH headings : Angiogenesis Inhibitors / administration & dosage; Angiogenesis Inhibitors / chemistry; Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Apoptosis / drug effects; Breast Neoplasms / drug therapy; Breast Neoplasms / genetics; Cell Line, Tumor; Cell Membrane Permeability / drug effects; Drug Delivery Systems; Endosomes / drug effects; Gene Transfer Techniques; Humans; Hyaluronoglucosaminidase / biosynthesis; Hyaluronoglucosaminidase / chemistry; Mice; Snake Venoms / administration & dosage; Snake Venoms / chemistry; TNF-Related Apoptosis-Inducing Ligand / administration & dosage; Tumor Microenvironment / drug effects; Xenograft Model Antitumor Assays
TL;DR: Equipped with an acid-degradable modality, the resulting CS-NG can substantially release combinational anticancer drugs-tumor necrosis factor-related apoptosis inducing ligand and antiangiogenic cilengitide toward the membrane of cancer cells and endothelial cells at the acidic tumor microenvironment, respectively. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Anticancer Platelet-Mimicking Nanovehicles

ADVANCED MATERIALS, 27(44), 7043-+.

By: Q. Hu n, W. Sun n, C. Qian n, C. Wang n, H. Bomba n & Z. Gu n

MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Biomimetic Materials / chemistry; Blood Platelets / cytology; Cell Line, Tumor; Cell Membrane / chemistry; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers / chemistry; Humans; Intracellular Space / metabolism; Mice; Nanomedicine / methods; Nanostructures / chemistry; TNF-Related Apoptosis-Inducing Ligand / chemistry; TNF-Related Apoptosis-Inducing Ligand / metabolism
TL;DR: A core-shell nanovehicle coated with a platelet membrane (PM) is developed for targeted and site-specific delivery of an extracellularly active drug and an intracellular functional small-molecular drug, leading to enhanced antitumor efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing

Angewandte Chemie International Edition, 54(41), 12029–12033.

By: W. Sun n, W. Ji n, J. Hall n, Q. Hu n, C. Wang n, C. Beisel n, Z. Gu n

author keywords: CRISPR-Cas9; DNA; drug delivery; genome editing; nanoparticles
MeSH headings : Animals; CRISPR-Associated Proteins / administration & dosage; CRISPR-Associated Proteins / chemistry; CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Line; Clustered Regularly Interspaced Short Palindromic Repeats; DNA / administration & dosage; DNA / chemistry; DNA / genetics; Green Fluorescent Proteins / genetics; Humans; Mice, Nude; Nanoparticles / chemistry; Neoplasms / genetics; Neoplasms / therapy; RNA, Guide, Kinetoplastida / administration & dosage; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; Streptococcus pyogenes / chemistry; Streptococcus pyogenes / genetics
TL;DR: The biologically inspired vehicles were efficiently loaded with Cas9/sgRNA complexes and delivered the complexes to the nuclei of human cells, thus enabling targeted gene disruption while maintaining cell viability. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 article

Spatiotemporal drug delivery using laser-generated-focused ultrasound system

Di, J., Kim, J., Hu, Q., Jiang, X., & Gu, Z. (2015, December 28). JOURNAL OF CONTROLLED RELEASE, Vol. 220, pp. 592–599.

By: J. Di n, J. Kim n, Q. Hu n, X. Jiang n & Z. Gu n

author keywords: Drug delivery; Photoacoustic; Nanoparticles; Microgels; Stimuli responsive
MeSH headings : Alginates / chemistry; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / chemistry; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / chemistry; Cell Proliferation / drug effects; Cell Survival / drug effects; Chemistry, Pharmaceutical; Ciprofloxacin / administration & dosage; Ciprofloxacin / chemistry; Delayed-Action Preparations; Dimethylpolysiloxanes / chemistry; Disk Diffusion Antimicrobial Tests; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers; Equipment Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Gels; Glucuronic Acid / chemistry; HeLa Cells; Hexuronic Acids / chemistry; Humans; Kinetics; Lactic Acid / chemistry; Lasers; Nanoparticles; Photoacoustic Techniques; Polyglycolic Acid / chemistry; Polylactic Acid-Polyglycolic Acid Copolymer; Solubility; Soot / chemistry; Spheroids, Cellular; Technology, Pharmaceutical / instrumentation; Technology, Pharmaceutical / methods; Transducers; Ultrasonic Waves; Ultrasonics / instrumentation; Ultrasonics / methods
TL;DR: This novel LGFU-responsive drug delivery system provides a simple and remote approach to precisely control the release of therapeutics in a spatiotemporal manner and potentially suppress detrimental effects to the surrounding tissue, such as thermal ablation. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Transformable liquid-metal nanomedicine

NATURE COMMUNICATIONS, 6(1).

By: Y. Lu n, Q. Hu n, Y. Lin n, D. Pacardo n, C. Wang n, W. Sun n, F. Ligler n, M. Dickey n, Z. Gu*

MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / chemistry; Cell Line, Tumor; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Drug Carriers / chemistry; Drug Delivery Systems / instrumentation; Drug Delivery Systems / methods; Female; Gallium / chemistry; Humans; Indium / chemistry; Metal Nanoparticles / chemistry; Mice; Mice, Inbred BALB C; Nanomedicine / instrumentation; Nanomedicine / methods; Neoplasms / drug therapy
TL;DR: A transformable liquid-metal nanomedicine, based on a core–shell nanosphere composed of a liquid-phase eutectic gallium-indium core and a thiolated polymeric shell, providing a new strategy for engineering theranostic agents with low toxicity. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Enzyme-responsive nanomaterials for controlled drug delivery

NANOSCALE, 6(21), 12273–12286.

By: Q. Hu n, P. Katti* & Z. Gu n

MeSH headings : Animals; Apoptosis; Biotechnology; Drug Delivery Systems; Enzymes / chemistry; Humans; Inorganic Chemicals / chemistry; Liposomes / chemistry; Metal Nanoparticles / chemistry; Mice; Nanostructures / chemistry; Nanotechnology; Oxidoreductases / chemistry; Peptide Hydrolases / chemistry; Phospholipases / chemistry
TL;DR: This review describes enzymes such as proteases, phospholipases and oxidoreductases that serve as delivery triggers and explores recently developed enzyme-responsive nanomaterials with versatile applications for extracellular and intracellular drug delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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