Rohan Ajit Shirwaiker

Works (69)

Updated: February 19th, 2026 16:37

2026 article

Design and Validation of a Multi-Modal Bioreactor System: Assessing the Effects of Perfusion and Cyclic Tensile Stimulation on Mechanical and Biological Properties of 3D-Printed Missing-Rib Auxetic Scaffolds

Sharmin, T., Hossan, S., & Shirwaiker, R. A. (2026, January 26). Bioengineering, Vol. 1.

By: T. Sharmin n, S. Hossan * & R. Shirwaiker 

topics (OpenAlex): Cellular and Composite Structures; Bone Tissue Engineering Materials; Tissue Engineering and Regenerative Medicine
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: January 29, 2026

2025 article

Digital light processing (DLP) bioprinting of collagen-riboflavin hydrogels for cultivated meat applications☆

Ahmed, N., & Shirwaiker, R. (2025, August 1). Manufacturing Letters, Vol. 8.

By: N. Ahmed n  & R. Shirwaiker n 

topics (OpenAlex): 3D Printing in Biomedical Research; Additive Manufacturing and 3D Printing Technologies; Collagen: Extraction and Characterization
Sources: NC State University Libraries, NC State University Libraries
Added: January 22, 2026

2025 article

Exploring the U.S. regulatory and legislative landscapes for cell-cultivated meat and seafood

Stanley, K. C., Koivusaari, K., Grieger, K., Wood, A., Jaffe, G., Aimutis, W. R., … Shirwaiker, R. A. (2025, December 31). Trends in Food Science & Technology, Vol. 12.

By: K. Stanley  n, K. Koivusaari n, K. Grieger n , A. Wood n, G. Jaffe n, W. Aimutis n, N. Wilson n, R. Shirwaiker n 

topics (OpenAlex): Food Supply Chain Traceability; Animal Genetics and Reproduction; World Trade Organization Law; Agriculture Sustainability and Environmental Impact; Genetically Modified Organisms Research
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: January 19, 2026

2024 journal article

3D melt blowing of Elastollan thermoplastic polyurethane for tissue engineering applications: A pilot study

Manufacturing Letters, 41, 357–363.

By: A. Pawar n, B. Anderson n, B. Pourdeyhimi n , A. McNulty *, M. Fisher n  & R. Shirwaiker n 

author keywords: tissue engineering; nonwoven; meltblowing; musculoskeletal; scaffolds; thermoplastic polyurethane; Elastollan
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials; Additive Manufacturing and 3D Printing Technologies
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: January 27, 2025

2024 article

A perspective on the environmental impact of plant-based protein concentrates and isolates

Aimutis, W. R., & Shirwaiker, R. (2024, December 2). Proceedings of the National Academy of Sciences, Vol. 121.

By: W. Aimutis n & R. Shirwaiker n 

author keywords: plant- based; protein; environmental impact; security
MeSH headings : Environment; Plant Proteins; Food Supply; Humans; Animals
topics (OpenAlex): Agriculture Sustainability and Environmental Impact; Food Waste Reduction and Sustainability; Muscle metabolism and nutrition
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2. Zero Hunger (Web of Science)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2024 article

A scoping review of cultivated meat techno-economic analyses to inform future research directions for scaled-up manufacturing

Goodwin, C. M., Aimutis, W. R., & Shirwaiker, R. A. (2024, October 18). Nature Food, Vol. 10.

By: C. Goodwin  n, W. Aimutis n & R. Shirwaiker n 

MeSH headings : Meat / economics; Animals; Bioreactors / economics; Humans; Food Technology / economics; In Vitro Meat
topics (OpenAlex): Agriculture Sustainability and Environmental Impact; Meat and Animal Product Quality; Food Waste Reduction and Sustainability
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2. Zero Hunger (Web of Science; OpenAlex)
13. Climate Action (Web of Science)
15. Life on Land (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 28, 2024

2024 article

Assessing design-induced elasticity of 3D printed auxetic scaffolds for tissue engineering applications

Sharmin, T., & Shirwaiker, R. (2024, October 1). Manufacturing Letters, Vol. 41, pp. 772–778.

By: T. Sharmin n & R. Shirwaiker n 

author keywords: Auxetic scaffolds; 3D bioplotting; scaffold elasticity; Negative Poisson's ratio; fatigue degradation
topics (OpenAlex): Additive Manufacturing and 3D Printing Technologies; Bone Tissue Engineering Materials; Cellular and Composite Structures
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Sources: Web Of Science, NC State University Libraries
Added: January 27, 2025

2024 article

Single-Component Cellulose Acetate Sulfate Hydrogels for Direct Ink Writing 3D Printing

Park, S., Park, S., Sharmin, T., Cho, S.-M., Kelley, S. S., Shirwaiker, R. A., … Park, S. (2024, August 21). Biomacromolecules, Vol. 8.

By: S. Park n, S. Park n , T. Sharmin n, S. Cho n, S. Kelley n , R. Shirwaiker n , S. Park  n, S. Park  n

Contributors: R. Shirwaiker n 

MeSH headings : Cellulose / chemistry; Cellulose / analogs & derivatives; Printing, Three-Dimensional; Hydrogels / chemistry; Hydrogels / chemical synthesis; Ink; Rheology; Viscosity
topics (OpenAlex): Additive Manufacturing and 3D Printing Technologies; Electrospun Nanofibers in Biomedical Applications; 3D Printing in Biomedical Research
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 22, 2024

2022 article

Investigating dielectric spectroscopy and soft sensing for nondestructive quality assessment of engineered tissues

Shohan, S., Zeng, Y., Chen, X., Jin, R., & Shirwaiker, R. (2022, May 16). Biosensors and Bioelectronics, Vol. 11.

By: S. Shohan n , Y. Zeng *, X. Chen *, R. Jin * & R. Shirwaiker n 

Contributors: S. Shohan n , Y. Zeng *, X. Chen *, R. Jin * & R. Shirwaiker n 

author keywords: Biofabrication; Dielectric spectroscopy; Non-destructive quality monitoring; Soft sensing; Tissue engineering
MeSH headings : Biosensing Techniques; Dielectric Spectroscopy / methods; Gelatin; Humans; Methacrylates; Tissue Engineering / methods
topics (OpenAlex): 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies; Viral Infectious Diseases and Gene Expression in Insects
TL;DR: A new soft-sensing approach with non-destructive dielectric spectroscopy (DS) that synergistically utilizes inline sensor data and predictive analytics to estimate unmeasured TEMP quality profiles is investigated, and a bilinear basis mixed model (BBMM) is developed as a soft sensor. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 18, 2022

2022 article

Multiphase CFD Modeling and Experimental Validation of Polymer and Attenuating Air Jet Interactions in Nonwoven Annular Melt Blowing

Schuchard, K. G., Pawar, A., Anderson, B., Pourdeyhimi, B., & Shirwaiker, R. A. (2022, September 6). Industrial & Engineering Chemistry Research, Vol. 9.

By: K. Schuchard n, A. Pawar n, B. Anderson n, B. Pourdeyhimi n  & R. Shirwaiker n 

topics (OpenAlex): Textile materials and evaluations; Aerosol Filtration and Electrostatic Precipitation; Electrospun Nanofibers in Biomedical Applications
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Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022

2022 article

Multiscale Anisotropic Tissue Biofabrication via Bulk Acoustic Patterning of Cells and Functional Additives in Hybrid Bioinks

Chansoria, P., Asif, S., Gupta, N., Piedrahita, J., & Shirwaiker, R. A. (2022, January 14). Advanced Healthcare Materials, Vol. 1.

By: P. Chansoria n, S. Asif n, N. Gupta  n, J. Piedrahita n  & R. Shirwaiker n 

author keywords: 3D cell patterning; biofabrication; bioprinting; GelMA; hybrid bioinks; standing bulk acoustic waves; ultrasound
MeSH headings : Acoustics; Anisotropy; Bioprinting; Gelatin / chemistry; Humans; Hydrogels / chemistry; Methacrylates; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds / chemistry
topics (OpenAlex): 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies; Additive Manufacturing and 3D Printing Technologies
TL;DR: A highly versatile ultrasound‐assisted biofabrication (UAB) approach is demonstrated that utilizes radiation forces generated by superimposing ultrasonic bulk acoustic waves to rapidly organize arrays of cells and other biomaterial additives within single and multilayered hydrogel constructs. (via Semantic Scholar)
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9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2021 article

Cell-Laden Nanocellulose/Chitosan-Based Bioinks for 3D Bioprinting and Enhanced Osteogenic Cell Differentiation

Maturavongsadit, P., Narayanan, L. K., Chansoria, P., Shirwaiker, R., & Benhabbour, S. R. (2021, February 17). ACS Applied Bio Materials, Vol. 4, pp. 2342–2353.

By: P. Maturavongsadit  n, L. Narayanan n, P. Chansoria n, R. Shirwaiker n  & S. Benhabbour n

author keywords: chitosan-based hydrogel; cellulose nanocrystal; bioink; osteogenic differentiation; bioprinting
MeSH headings : 3T3 Cells; Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Bioprinting; Cell Differentiation / drug effects; Cells, Cultured; Cellulose / chemistry; Cellulose / pharmacology; Chitosan / chemistry; Chitosan / pharmacology; Ink; Materials Testing; Mice; Nanoparticles / chemistry; Osteogenesis / drug effects; Particle Size
topics (OpenAlex): 3D Printing in Biomedical Research; Innovative Microfluidic and Catalytic Techniques Innovation; Cell Image Analysis Techniques
TL;DR: The versatility of this CNCs-incorporated chitosan hydrogel makes it attractive as a bioink for 3D bioprinting to engineer scaffolds for bone tissue engineering and other therapeutic applications. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021

2021 article

Characterizing the Effects of Synergistic Thermal and Photo-Cross-Linking during Biofabrication on the Structural and Functional Properties of Gelatin Methacryloyl (GelMA) Hydrogels

Chansoria, P., Asif, S., Polkoff, K., Chung, J., Piedrahita, J. A., & Shirwaiker, R. A. (2021, October 1). ACS Biomaterials Science & Engineering, Vol. 11, pp. 5175–5188.

By: P. Chansoria n, S. Asif n, K. Polkoff n, J. Chung n, J. Piedrahita n  & R. Shirwaiker n 

author keywords: GelMA; thermo-reversible cross-linking; photo-cross-linking; biofabrication; tissue engineering; CryoSEM; qPCR
MeSH headings : Biocompatible Materials; Gelatin; Humans; Hydrogels; Methacrylates; Tissue Engineering
topics (OpenAlex): Additive Manufacturing and 3D Printing Technologies; 3D Printing in Biomedical Research; Collagen: Extraction and Characterization
TL;DR: The finding that hydrogels processed at higher temperature possessed lower structural fidelity but resulted in more cell elongation and greater anisotropy over time demonstrate the significant impact of GelMA material formulation and processing conditions on the structural and functional properties of the hydrogel. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021

2021 article

Fabrication of drug-loaded ultrafine polymer fibers via solution blowing and their drug release kinetics

Schuchard, K., Joijode, A., Willard, V. P., Anderson, B., Grondin, P., Pourdeyhimi, B., & Shirwaiker, R. (2021, January 1). Procedia Manufacturing.

By: K. Schuchard n, A. Joijode n , V. Willard *, B. Anderson n, P. Grondin n, B. Pourdeyhimi n , R. Shirwaiker n 

author keywords: solution blowing; biofabrication; fibers; doxycycline; drug release
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Electrohydrodynamics and Fluid Dynamics
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Sources: Web Of Science, NC State University Libraries
Added: October 24, 2022

2021 article

Non-destructive quality monitoring of 3D printed tissue scaffolds via dielectric impedance spectroscopy and supervised machine learning

Shohan, S., Harm, J., Hasan, M., Starly, B., & Shirwaiker, R. (2021, January 1). Procedia Manufacturing, Vol. 53, pp. 636–643.

By: S. Shohan n , J. Harm n, M. Hasan n, B. Starly n  & R. Shirwaiker n 

author keywords: biofabrication; non-destructive quality monitoring; supervised machine learning; dielectric impedance spectroscopy; tissue engineering
topics (OpenAlex): 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies; Viral Infectious Diseases and Gene Expression in Insects
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2022

2021 article

Steroid eluting biocompatible stent for subglottic stenosis

Manzi, B., Shirwaiker, R., Gungor, A., & Weinberger, P. (2021, January 2). European Archives of Oto-Rhino-Laryngology.

By: B. Manzi *, R. Shirwaiker n , A. Gungor * & P. Weinberger *

author keywords: Subglottic stenosis; Tracheal stent; Dissolvable; Endoscopic intervention
MeSH headings : Animals; Constriction, Pathologic; Drug-Eluting Stents; Laryngostenosis / surgery; Rabbits; Stents; Steroids; Trachea
topics (OpenAlex): Tracheal and airway disorders
TL;DR: This proof-of-concept project is an initial step to demonstrate and create a novel stent in the treatment of subglottic stenosis that applies expansile force on the trachea, elutes steroids and dissolves over time. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 25, 2021

2021 article

The evaluation of a multiphasic 3D‐bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model

Nordberg, R. C., Huebner, P., Schuchard, K. G., Mellor, L. F., Shirwaiker, R. A., Loboa, E. G., & Spang, J. T. (2021, June 10). Journal of Biomedical Materials Research Part B Applied Biomaterials, Vol. 6.

By: R. Nordberg n, P. Huebner  n, K. Schuchard n, L. Mellor  n, R. Shirwaiker n , E. Loboa*, J. Spang *

author keywords: in vivo; osteochondral; stem cells; tissue engineering; 3D-printing
MeSH headings : Animals; Cartilage, Articular / injuries; Stem Cells; Swine; Swine, Miniature; Tissue Engineering / methods; Tissue Scaffolds / chemistry
topics (OpenAlex): Osteoarthritis Treatment and Mechanisms; Knee injuries and reconstruction techniques; Periodontal Regeneration and Treatments
TL;DR: Overall, scaffold groups repaired the defect more successfully than an open lesion but achieved limited repair in the cartilage region, indicating that this approach holds potential to treat focal cartilage lesions in a highly personalized manner using a human patient's own ASC cells. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 21, 2021

2020 article

3D bioprinting of anisotropic engineered tissue constructs with ultrasonically induced cell patterning

Chansoria, P., & Shirwaiker, R. (2020, January 7). Additive Manufacturing, Vol. 32.

By: P. Chansoria n & R. Shirwaiker n 

author keywords: Bioprinting; Ultrasound; Biomimicry; Standing bulk acoustic wave (SBAW); Alginate; GelMA
topics (OpenAlex): 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies; Cellular Mechanics and Interactions
TL;DR: This study describes a new bioprinting technique that uses ultrasonic standing bulk acoustic waves (SBAW) to organize cells into controllable anisotropic patterns within viscous bioinks while maintaining high cell viability. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020

2020 article

Biofabricated 3D in vitro model of fibrosis‐induced abnormal hepatoblast/biliary progenitors' expansion of the developing liver

Brovold, M., Keller, D., Devarasetty, M., Dominijanni, A., Shirwaiker, R., & Soker, S. (2020, December 6). Bioengineering & Translational Medicine, Vol. 12.

By: M. Brovold*, D. Keller*, M. Devarasetty *, A. Dominijanni *, R. Shirwaiker n  & S. Soker *

author keywords: 3D organoids; biliary development; fibrosis; HepaRG; hepatic stellate cell
topics (OpenAlex): Liver physiology and pathology; Organ Transplantation Techniques and Outcomes; Pediatric Hepatobiliary Diseases and Treatments
TL;DR: A simple yet robust model that recapitulates physico‐mechanical and cellular aspects of fibrosis mediated via hepatic stellate cells (HSCs) and their effects on biliary progenitor cells is developed to benefit pediatric patients that suffer from the biliary dysgenesis associated with a multitude of congenital liver diseases. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: May 28, 2021

2020 article

Effects of Autoclaving, EtOH, and UV Sterilization on the Chemical, Mechanical, Printability, and Biocompatibility Characteristics of Alginate

Chansoria, P., Narayanan, L. K., Wood, M., Alvarado, C., Lin, A., & Shirwaiker, R. A. (2020, July 21). ACS Biomaterials Science & Engineering, Vol. 6, pp. 5191–5201.

By: P. Chansoria n, L. Narayanan n, M. Wood n, C. Alvarado n, A. Lin  n & R. Shirwaiker n 

author keywords: hydrogels; tissue engineering and regenerative medicine; biofabrication; printability; human adipose-derived stem cells (hASC); nuclear magnetic resonance spectroscopy
MeSH headings : Alginates; Anti-Bacterial Agents; Ethanol; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Sterilization
topics (OpenAlex): 3D Printing in Biomedical Research; Hydrogels: synthesis, properties, applications; Electrospun Nanofibers in Biomedical Applications
TL;DR: The autoclaving process, while demonstrating broad spectrum sterility effectiveness, also resulted in most notable changes in alginate's key properties, which significantly reduced the molecular weight and polydispersity index, as determined via gel permeation chromatography, as well as the dynamic viscosity ofAlginate. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2020 article

Experimental Characterization and Finite Element Modeling of the Effects of 3D Bioplotting Process Parameters on Structural and Tensile Properties of Polycaprolactone (PCL) Scaffolds

Narayanan, L. K., & Shirwaiker, R. A. (2020, July 30). Applied Sciences, Vol. 10, p. 5289.

By: L. Narayanan  n & R. Shirwaiker n 

author keywords: 3D Bioplotting; scaffolds; finite element analysis; tensile strength; PCL
topics (OpenAlex): Additive Manufacturing and 3D Printing Technologies; biodegradable polymer synthesis and properties; Electrospun Nanofibers in Biomedical Applications
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Source: ORCID
Added: August 4, 2020

2020 journal article

High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine

Tissue Engineering Part C: Methods, 26(7), 364–374.

By: R. Shirwaiker n , M. Fisher n , B. Anderson n, K. Schuchard n, P. Warren n, B. Maze n , P. Grondin n, F. Ligler n, B. Pourdeyhimi n 

Contributors: R. Shirwaiker n , M. Fisher n , B. Anderson n, K. Schuchard n, P. Warren n, B. Maze n , P. Grondin n, F. Ligler n, B. Pourdeyhimi n 

author keywords: 3D printing; melt blowing; fibers; scaffolds
MeSH headings : Animals; Biocompatible Materials / chemistry; Dogs; Hernia / therapy; Herniorrhaphy / methods; Polymers / chemistry; Printing, Three-Dimensional / instrumentation; Regenerative Medicine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Tissue Engineering and Regenerative Medicine; Additive Manufacturing and 3D Printing Technologies
TL;DR: The 3DMB system described in this study is modified from larger nonwovens manufacturing machinery to accommodate the lower volume, high-cost polymers used for tissue engineering and implantable biomedical devices and has a fiber collection component that uses adaptable robotics to create scaffolds with predetermined geometries. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: August 10, 2020

2020 article

Process hybridization schemes for multiscale engineered tissue biofabrication

Chansoria, P., Schuchard, K., & Shirwaiker, R. A. (2020, October 21). Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Vol. 13.

By: P. Chansoria n, K. Schuchard n & R. Shirwaiker n 

author keywords: biofabrication; biomimetics; hybrid processes; tissue engineering and regenerative medicine
MeSH headings : Biomimetics; Nanotechnology; Tissue Engineering; Tissue Scaffolds
topics (OpenAlex): 3D Printing in Biomedical Research; Additive Manufacturing and 3D Printing Technologies; Bone Tissue Engineering Materials
TL;DR: This work discusses recent literature in this domain and attempts to equip the reader with the understanding of selecting appropriate processes that can harmonize toward creating engineered tissues with appropriate multiscale structure-function properties. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 9, 2020

2020 journal article

Review: Modeling in Situ Liver Cancer

Annals of Gastroenterology and Digestive Disorders. https://www.somatopublications.com/review-modeling-in-situ-liver-cancer.pdf

Rohan Shirwaiker

www.somatopublications.com
Source: ORCID
Added: May 28, 2021

2020 article

Ultrasound-assisted vat photopolymerization 3D printing of preferentially organized carbon fiber reinforced polymer composites

Asif, S., Chansoria, P., & Shirwaiker, R. (2020, April 27). Journal of Manufacturing Processes, Vol. 56, pp. 1340–1343.

By: S. Asif n, P. Chansoria n & R. Shirwaiker n 

author keywords: Additive manufacturing; Vat photopolymerization; Ultrasound; Bulk acoustic wave; Carbon fiber reinforced composites
topics (OpenAlex): Additive Manufacturing and 3D Printing Technologies; 3D Printing in Biomedical Research; Photopolymerization techniques and applications
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Sources: Web Of Science, NC State University Libraries
Added: February 1, 2021

2019 article

Characterizing the Process Physics of Ultrasound-Assisted Bioprinting

Chansoria, P., & Shirwaiker, R. (2019, September 25). Scientific Reports, Vol. 9.

By: P. Chansoria  n & R. Shirwaiker n 

topics (OpenAlex): 3D Printing in Biomedical Research; Microfluidic and Bio-sensing Technologies; Innovative Microfluidic and Catalytic Techniques Innovation
TL;DR: This work describes the underlying process physics and develops and validate computational models to determine the effects of ultrasound process parameters on the relevant temperature, pressure distribution, and alignment time characteristics and demonstrates the UAB of bilayered constructs with parallel (0°–0°) and orthogonal cellular alignment across layers. (via Semantic Scholar)
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Added: October 14, 2019

2019 article

Investigation of multiphasic 3D‐bioplotted scaffolds for site‐specific chondrogenic and osteogenic differentiation of human adipose‐derived stem cells for osteochondral tissue engineering applications

Mellor, L. F., Nordberg, R. C., Huebner, P., Mohiti‐Asli, M., Taylor, M. A., Efird, W., … Loboa, E. G. (2019, December 27). Journal of Biomedical Materials Research Part B Applied Biomaterials.

By: L. Mellor n, R. Nordberg n, P. Huebner  n, M. Mohiti‐Asli  n, M. Taylor n, W. Efird*, J. Oxford *, J. Spang *, R. Shirwaiker n , E. Loboa*

author keywords: 3D-printing; chondrogenic differentiation; human adipose derived stem cells; osteochondral; osteogenic differentiation
MeSH headings : Adipose Tissue / metabolism; Biocompatible Materials / chemistry; Bone and Bones; Calcium Phosphates / chemistry; Calcium Phosphates / metabolism; Cartilage, Articular / metabolism; Cell Differentiation; Cells, Cultured; Chondrogenesis / physiology; Collagen Type I / genetics; Collagen Type I / metabolism; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / physiology; Polyesters / chemistry; Polyesters / metabolism; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds / chemistry
topics (OpenAlex): Mesenchymal stem cell research; Osteoarthritis Treatment and Mechanisms; Tissue Engineering and Regenerative Medicine
TL;DR: A scaffold that would induce site‐specific osteogenic and chondrogenic differentiation of human adipose‐derived stem cells (hASC) to generate a full osteochondral implant is created and holds great promise as cartilage morbidity is minimized since autologous cartilage harvest is not required. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 6, 2020

2019 journal article

Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment

Connective Tissue Research, 61(2), 190–204.

By: P. Huebner  n, P. Warren n, D. Chester n, J. Spang *, A. Brown n , M. Fisher n , R. Shirwaiker n 

author keywords: 3D printing; atomic force microscopy; elastic modulus; tissue engineering; tissue scaffolds
MeSH headings : Animals; Bioprinting; Collagen / chemistry; Extracellular Matrix / chemistry; Male; Polyesters / chemistry; Printing, Three-Dimensional; Rats; Rats, Sprague-Dawley; Tissue Engineering; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials; Tissue Engineering and Regenerative Medicine
TL;DR: The findings demonstrate the significant effects of 3D-bioplotted scaffold microarchitectures in the organization and sub-tissue-level mechanical properties of ECM in vivo. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 26, 2019

2019 article

Ultrasound-assisted biofabrication and bioprinting of preferentially aligned three-dimensional cellular constructs

Chansoria, P., Narayanan, L. K., Schuchard, K., & Shirwaiker, R. (2019, April 3). Biofabrication, Vol. 11.

By: P. Chansoria  n, L. Narayanan n, K. Schuchard  n & R. Shirwaiker n 

author keywords: biofabrication; bioprinting; ultrasound; tissue engineering; 3D acoustic patterning; standing bulk acoustic waves; 3D cell manipulation
MeSH headings : Acoustics; Adipose Tissue / cytology; Alginates / pharmacology; Bioprinting / methods; Cell Survival / drug effects; Finite Element Analysis; Humans; Ink; Menisci, Tibial / drug effects; Pressure; Printing, Three-Dimensional; Stem Cells / cytology; Stem Cells / drug effects; Tissue Scaffolds / chemistry; Transducers; Ultrasonics; Viscosity
topics (OpenAlex): Microfluidic and Bio-sensing Technologies; 3D Printing in Biomedical Research; Planarian Biology and Electrostimulation
TL;DR: A new acoustophoretic three-dimensional (3D) biofabrication approach that utilizes radiation forces generated by superimposing ultrasonic bulk acoustic waves (BAW) to preferentially organize cellular arrays within single and multi-layered hydrogel constructs is described. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 20, 2019

2018 article

Label free process monitoring of 3D bioprinted engineered constructs via dielectric impedance spectroscopy

Narayanan, L. K., Thompson, T. L., Shirwaiker, R. A., & Starly, B. (2018, June 14). Biofabrication, Vol. 10.

By: L. Narayanan n, T. Thompson n, R. Shirwaiker n  & B. Starly n 

author keywords: FDA PAT; Process Analytical Technology; bioprinting process parameters; biofabrication process monitoring; quality assessment
MeSH headings : Bioprinting / standards; Cell Line; Cell Survival / physiology; Cells, Cultured; Dielectric Spectroscopy / methods; Humans; Materials Testing / methods; Printing, Three-Dimensional; Stem Cells / cytology; Tissue Engineering / standards
topics (OpenAlex): 3D Printing in Biomedical Research; Additive Manufacturing and 3D Printing Technologies; Microfluidic and Bio-sensing Technologies
TL;DR: The findings of this study support the use of dielectric impedance spectroscopy as a label-free and non-destructive method to characterize the critical quality attributes of bioprinted constructs. (via Semantic Scholar)
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Added: August 6, 2018

2018 article

The Ion Delivery Manner Influences the Antimicrobial Efficacy of Silver Oligodynamic Iontophoresis

Tan, G. Z., Orndorff, P. E., & Shirwaiker, R. A. (2018, September 14). Journal of Medical and Biological Engineering, Vol. 39, pp. 622–631.

By: G. Tan *, P. Orndorff n & R. Shirwaiker n 

author keywords: Oligodynamic iontophoresis; Silver ion; Antimicrobial activities; Electrical activation
topics (OpenAlex): Microfluidic and Bio-sensing Technologies; Electrowetting and Microfluidic Technologies; Molecular Communication and Nanonetworks
TL;DR: The antimicrobial activities of the silver-based iontophoresis prototype was more sensitive to current duration than current intensity, and the marginal antimicrobial efficacy of the device decreased as the current intensity increased. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 5, 2019

2017 article

Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver–titanium implant system prototype

Tan, Z., Havell, E. A., Orndorff, P. E., & Shirwaiker, R. A. (2017, January 16). BioMetals, Vol. 30, pp. 113–125.

By: Z. Tan n, E. Havell n, P. Orndorff n & R. Shirwaiker n 

Contributors: Z. Tan n, E. Havell n, P. Orndorff n & R. Shirwaiker n 

author keywords: Low intensity direct current; Silver-titanium implant; Orthopaedic application; Antimicrobial efficacy; Cytotoxicity
MeSH headings : Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Cell Proliferation / drug effects; Ions / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Titanium / chemistry; Titanium / pharmacology
topics (OpenAlex): Nanoparticles: synthesis and applications; Bone Tissue Engineering Materials; Graphene and Nanomaterials Applications
TL;DR: The in vitro antibacterial efficacy and cytotoxicity of a low intensity direct current (LIDC)-activated silver–titanium implant system prototype designed for localized generation and delivery of silver ions at the implantation site showed high antimicrobial efficacy against MRSA, but was also toxic to human cells immediately surrounding the electrodes. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 journal article

Characterizing effects of 3D-bioplotted polycaprolactone (PCL) scaffold geometry on human adipose-derived stem cell viability and proliferation

Rapid Prototyping Journal, 23(3).

By: S. Mehendale, L. Mellor, M. Taylor, E. Loboa & R. Shirwaiker 

Source: NC State University Libraries
Added: August 6, 2018

2017 article

Effects of 3D-bioplotted polycaprolactone scaffold geometry on human adipose-derived stem cell viability and proliferation

Mehendale, S. V., Mellor, L. F., Taylor, M. A., Loboa, E. G., & Shirwaiker, R. A. (2017, March 17). Rapid Prototyping Journal, Vol. 23, pp. 534–542.

By: S. Mehendale n, L. Mellor n, M. Taylor n, E. Loboa n & R. Shirwaiker n 

Contributors: S. Mehendale n, L. Mellor n, M. Taylor n, E. Loboa n & R. Shirwaiker n 

author keywords: 3D-Bioplotting; Human adipose-derived stem cells; Polycaprolactone; Tissue engineering scaffolds
topics (OpenAlex): Bone Tissue Engineering Materials; 3D Printing in Biomedical Research; Orthopaedic implants and arthroplasty
TL;DR: The design with the lowest porosity had the highest compression modulus after 14 days of culture, but resulted in the lowest hASC viability, which provided the basis for future studies which will use this optimal scaffold design to develop constructs for hASC-based osteochondral tissue engineering applications. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications

Mellor, L. F., Huebner, P., Cai, S., Mohiti-Asli, M., Taylor, M. A., Spang, J., … Loboa, E. G. (2017, January 1). BioMed Research International, Vol. 2017.

By: L. Mellor n, P. Huebner n, S. Cai n, M. Mohiti-Asli n, M. Taylor n, J. Spang *, R. Shirwaiker n , E. Loboa *

Contributors: L. Mellor n, P. Huebner n, S. Cai n, M. Mohiti-Asli n, M. Taylor n, J. Spang *, R. Shirwaiker n , E. Loboa *

MeSH headings : Animals; Cells, Cultured; Extracellular Matrix / chemistry; Humans; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / therapeutic use; Porosity; Printing, Three-Dimensional; Swine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials; 3D Printing in Biomedical Research
TL;DR: The approach combining these two commonly used scaffold fabrication technologies allows for the creation of a scaffold with more close resemblance to heterogeneous tissue architecture, holding great potential for tissue engineering and regenerative medicine applications of osteochondral tissue and other heterogeneous tissues. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

Investigating Dielectric Impedance Spectroscopy As a Non-Destructive Quality Assessment Tool for 3D Cellular Constructs

Narayanan, L. K., Thompson, T. L., Bhat, A., Starly, B., & Shirwaiker, R. A. (2017, June 4). Proceedings of the ASME 12th International Manufacturing Science and Engineering Conference - 2017, Vol 4.

By: L. Narayanan n, T. Thompson n, A. Bhat*, B. Starly n  & R. Shirwaiker n 

topics (OpenAlex): 3D Printing in Biomedical Research; Pluripotent Stem Cells Research; Microfluidic and Bio-sensing Technologies
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2017 article

Investigating dielectric impedance spectroscopy as a non-destructive quality assessment tool for 3D cellular constructs

ASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 Collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing, Vol. 4.

By: L. Narayanan, T. Thompson, A. Bhat, B. Starly & R. Shirwaiker 

Contributors: L. Narayanan, T. Thompson, A. Bhat, B. Starly & R. Shirwaiker 

topics (OpenAlex):
Source: ORCID
Added: September 6, 2019

2017 conference paper

Non-destructive quality assessment of 3D-biofabricated constructs using dielectric impedance spectroscopy

67th Annual Conference and Expo of the Institute of Industrial Engineers 2017, 1846–1851. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030973322&partnerID=MN8TOARS

By: L. Narayanan, B. Starly & R. Shirwaiker 

Contributors: L. Narayanan, B. Starly & R. Shirwaiker 

www.scopus.com
Source: ORCID
Added: September 6, 2019

2016 journal article

3D-Bioprinting of Polylactic Acid (PLA) Nanofiber–Alginate Hydrogel Bioink Containing Human Adipose-Derived Stem Cells

ACS Biomaterials Science & Engineering, 2(10), 1732–1742.

By: L. Narayanan n, P. Huebner n, M. Fisher n , J. Spang *, B. Starly n  & R. Shirwaiker n 

Contributors: L. Narayanan n, P. Huebner n, M. Fisher n , J. Spang *, B. Starly n  & R. Shirwaiker n 

author keywords: bioprinting; knee meniscus; alginate; nanofibers; adipose-derived stem cells; musculoskeletal soft tissue
topics (OpenAlex): 3D Printing in Biomedical Research; Bone Tissue Engineering Materials; Additive Manufacturing and 3D Printing Technologies
TL;DR: This study focuses on the development and proof-of-concept assessment of a fibrous bioink composed of alginate hydrogel, polylactic acid nanofibers, and human adipose-derived stem cells for bioprinting such tissue constructs and shows that the nanofiber-reinforced bioink allowed higher levels of cell proliferation within biopprinted strands. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 article

Effects of Electrically Activated Silver–Titanium Implant System Design Parameters on Time-Kill Curves Against Staphylococcus aureus

Tan, Z., Xu, G., Orndorff, P. E., & Shirwaiker, R. A. (2016, June 1). Journal of Medical and Biological Engineering, Vol. 36, pp. 325–333.

By: Z. Tan n, G. Xu n, P. Orndorff n & R. Shirwaiker n 

Contributors: Z. Tan n, G. Xu n, P. Orndorff n & R. Shirwaiker n 

author keywords: Antimicrobial efficacy; Orthopaedic implants; Ionic silver; Post-operative infections; Design parameters
topics (OpenAlex): Nanoparticles: synthesis and applications; Bone Tissue Engineering Materials; Neuroscience and Neural Engineering
TL;DR: The in vitro antimicrobial efficacy of a silver-based prophylactic system for orthopaedic implant applications is characterized and provides a reference of design parameters for future product engineering. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Engineering 3D-Bioplotted scaffolds to induce aligned extracellular matrix deposition for musculoskeletal soft tissue replacement

Connective Tissue Research, 58(3-4), 342–354.

By: P. Warren n, P. Huebner n, J. Spang *, R. Shirwaiker n  & M. Fisher n 

Contributors: P. Warren n, P. Huebner n, J. Spang *, R. Shirwaiker n  & M. Fisher n 

author keywords: Biofabrication; meniscus; tissue engineering; scaffold; 3D printing
MeSH headings : Animals; Cell Count; Cell Shape; Collagen / metabolism; Extracellular Matrix / metabolism; Imaging, Three-Dimensional; Male; Musculoskeletal Physiological Phenomena; Rats, Sprague-Dawley; Regeneration / physiology; Sus scrofa; Tissue Engineering / methods; Tissue Scaffolds / chemistry
topics (OpenAlex): Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials; Tissue Engineering and Regenerative Medicine
TL;DR: The ability to use interstrand spacing as a means of controlling the formation of aligned collagen in vivo was demonstrated, which helps establish a design space for scaffold-based meniscus tissue engineering. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 article

In vitro characterization of design and compressive properties of 3D-biofabricated/decellularized hybrid grafts for tracheal tissue engineering

Johnson, C., Sheshadri, P., Ketchum, J. M., Narayanan, L. K., Weinberger, P. M., & Shirwaiker, R. A. (2016, April 1). Journal of the Mechanical Behavior of Biomedical Materials/Journal of Mechanical Behavior of Biomedical Materials, Vol. 59, pp. 572–585.

By: C. Johnson*, P. Sheshadri n, J. Ketchum *, L. Narayanan n, P. Weinberger * & R. Shirwaiker n 

Contributors: C. Johnson*, P. Sheshadri n, J. Ketchum *, L. Narayanan n, P. Weinberger * & R. Shirwaiker n 

author keywords: Trachea; Scaffolds; Tissue engineering; Decellularized ECM; Biofabrication
MeSH headings : Animals; Cartilage; Compressive Strength; Prosthesis Design; Swine; Tissue Engineering; Tissue Scaffolds; Trachea
topics (OpenAlex): Tracheal and airway disorders; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
TL;DR: The data support the possibility that future embodiments using a hybrid graft approach may reduce the need for intraluminal stenting in tracheal transplant recipients, and show that the resistance to compression offered by the hybrid grafts created using gamma radiation sterilized scaffolds was comparable to that of fresh trachesal segments. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

3D Bioprinting Techniques

Starly, B., & Shirwaiker, R. (2015, January 1). Elsevier EBooks, pp. 57–77.

By: B. Starly & R. Shirwaiker* 

Contributors: B. Starly & R. Shirwaiker* 

topics (OpenAlex): 3D Printing in Biomedical Research; Innovative Microfluidic and Catalytic Techniques Innovation; Additive Manufacturing and 3D Printing Technologies
TL;DR: The single biggest advantage of 3D bioprinting is the ability to digitally define the tissue construct of interest and reproduce the physical 3D structure through automated techniques and at resolutions not possible through any conventional photolithography techniques. (via Semantic Scholar)
Source: ORCID
Added: September 6, 2019

2015 article

A Clinical Perspective on Musculoskeletal Infection Treatment Strategies and Challenges

Shirwaiker, R. A., Springer, B. D., Spangehl, M. J., Garrigues, G. E., Lowenberg, D. W., Garras, D. N., … Pottinger, P. S. (2015, March 25). Journal of the American Academy of Orthopaedic Surgeons, Vol. 23, pp. S44–S54.

By: R. Shirwaiker n , B. Springer *, M. Spangehl *, G. Garrigues *, D. Lowenberg *, D. Garras, J. Yoo *, P. Pottinger *

Contributors: R. Shirwaiker n , B. Springer *, M. Spangehl *, G. Garrigues *, D. Lowenberg *, D. Garras, J. Yoo *, P. Pottinger *

MeSH headings : Arthritis, Infectious / etiology; Arthritis, Infectious / prevention & control; Arthritis, Infectious / therapy; Arthroplasty, Replacement / adverse effects; Arthroplasty, Replacement / instrumentation; Bone Diseases, Infectious / etiology; Bone Diseases, Infectious / prevention & control; Bone Diseases, Infectious / therapy; Humans; Joint Prosthesis / trends; Nanotechnology / trends; Prosthesis-Related Infections / prevention & control; Prosthesis-Related Infections / therapy; Surgical Wound Infection / etiology; Surgical Wound Infection / prevention & control; Surgical Wound Infection / therapy
topics (OpenAlex): Orthopedic Infections and Treatments; Orthopaedic implants and arthroplasty; Total Knee Arthroplasty Outcomes
TL;DR: Novel prevention methods, such as nanotechnology and the introduction of antibiotic-coated implants, may aid in the prevention and early treatment of periprosthetic joint infections with goals of improved eradication rates and maintaining patient mobility and satisfaction. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 journal article

Alginate Microspheroid Encapsulation and Delivery of MG-63 Cells Into Polycaprolactone Scaffolds: A New Biofabrication Approach for Tissue Engineering Constructs

Journal of Nanotechnology in Engineering and Medicine, 6(2).

By: L. Narayanan  n, A. Kumar n, Z. Tan  n, S. Bernacki  n, B. Starly n  & R. Shirwaiker n 

Contributors: L. Narayanan  n, A. Kumar n, Z. Tan  n, S. Bernacki  n, B. Starly n  & R. Shirwaiker n 

topics (OpenAlex): 3D Printing in Biomedical Research; Tissue Engineering and Regenerative Medicine; Electrospun Nanofibers in Biomedical Applications
TL;DR: A new cell delivery approach utilizing deposition of hydrogel-cell encapsulated microspheroids into polycaprolactone (PCL) scaffolds to improve the seeding efficiency is investigated and the role and critical challenges to be addressed are highlighted to successfully utilize 3D-bioprinting for microencapsulated cell delivery. (via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 6, 2019

2015 article

Characterization of Material–Process–Structure Interactions in the 3D Bioplotting of Polycaprolactone

Sheshadri, P., & Shirwaiker, R. A. (2015, March 1). 3D Printing and Additive Manufacturing, Vol. 2, pp. 20–31.

By: P. Sheshadri n & R. Shirwaiker n 

Contributors: P. Sheshadri n & R. Shirwaiker n 

topics (OpenAlex): Additive Manufacturing and 3D Printing Technologies; Bone Tissue Engineering Materials; 3D Printing in Biomedical Research
TL;DR: The relationship between PCL dynamic viscosity and extrusion temperature during bioplotting was determined using rheological measurements and the ANOVA results demonstrated that the strand widt strength was higher than expected. (via Semantic Scholar)
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Source: ORCID
Added: September 6, 2019

2015 article

Effects of cathode design parameters on in vitro antimicrobial efficacy of electrically-activated silver-based iontophoretic system

Tan, Z., Ganapathy, A., Orndorff, P. E., & Shirwaiker, R. A. (2015, January 1). Journal of Materials Science Materials in Medicine, Vol. 26, pp. 1–10.

By: Z. Tan  n, A. Ganapathy n, P. Orndorff n & R. Shirwaiker n 

Contributors: Z. Tan  n, A. Ganapathy n, P. Orndorff n & R. Shirwaiker n 

MeSH headings : Anti-Infective Agents / chemistry; Aspergillus flavus / drug effects; Diffusion; Electrochemistry / methods; Electrodes; Equipment Design; Escherichia coli / drug effects; Iontophoresis / methods; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Silver / chemistry; Staphylococcus aureus / drug effects; Streptococcus agalactiae / drug effects; Titanium / chemistry
topics (OpenAlex): Bone Tissue Engineering Materials; Bacterial biofilms and quorum sensing; Orthopedic Infections and Treatments
TL;DR: The ability to alter the cathode material and related design parameters in order to minimize the silver usage in the system without adversely affecting its antimicrobial efficacy is demonstrated. (via Semantic Scholar)
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Source: ORCID
Added: September 6, 2019

2015 article

Evaluation of silver‐titanium implants activated by low intensity direct current for orthopedic infection control: An in vitro and in vivo study

Cavanaugh, D. L., Tan, Z., Norris, J. P., Hardee, A., Weinhold, P. S., Dahners, L. E., … Shirwaiker, R. A. (2015, May 21). Journal of Biomedical Materials Research Part B Applied Biomaterials, Vol. 104, pp. 1023–1031.

By: D. Cavanaugh *, Z. Tan n, J. Norris *, A. Hardee n, P. Weinhold n, L. Dahners*, P. Orndorff n, R. Shirwaiker n 

Contributors: D. Cavanaugh *, Z. Tan n, J. Norris *, A. Hardee n, P. Weinhold n, L. Dahners*, P. Orndorff n, R. Shirwaiker n 

author keywords: prosthetic infection; oligodynamic silver; antimicrobial implant; electrical activation
MeSH headings : Animals; Female; Femur / microbiology; Femur / surgery; Implants, Experimental; Rats; Rats, Sprague-Dawley; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / prevention & control; Staphylococcus aureus / growth & development; Titanium / chemistry; Titanium / pharmacology
topics (OpenAlex): Bone Tissue Engineering Materials; Orthopaedic implants and arthroplasty; Nanoparticles: synthesis and applications
TL;DR: In vivo, none of the four groups were able to prevent wound infection, but the experimental group resulted in reduced colonization, and the antimicrobial potential of LIDC-activated Ag-Ti implants is demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Manufacturing Road Map for Tissue Engineering and Regenerative Medicine Technologies

Hunsberger, J., Harrysson, O., Shirwaiker, R., Starly, B., Wysk, R., Cohen, P., … Atala, A. (2015, January 9). Stem Cells Translational Medicine, Vol. 4, pp. 130–135.

By: J. Hunsberger *, O. Harrysson n , R. Shirwaiker n , B. Starly n , R. Wysk n, P. Cohen n , J. Allickson*, J. Yoo *, A. Atala *

Contributors: J. Hunsberger *, O. Harrysson n , R. Shirwaiker n , B. Starly n , R. Wysk n, P. Cohen n , J. Allickson*, J. Yoo *, A. Atala *

MeSH headings : Biological Specimen Banks; Drug Industry / methods; Drug Industry / organization & administration; Humans; Regenerative Medicine / methods; Regenerative Medicine / organization & administration; Tissue Engineering / methods; Translational Research, Biomedical / methods; Translational Research, Biomedical / organization & administration
topics (OpenAlex): Biomedical Ethics and Regulation; Biomedical and Engineering Education; 3D Printing in Biomedical Research
TL;DR: A road map for developing the manufacturing infrastructure, resources, standards, capabilities, education, training, and workforce development to realize the promise of TERM is outlined. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Scaffolding hydrogels for rapid prototyping based tissue engineering

Shirwaiker, R. A., Purser, M. F., & Wysk, R. A. (2014, January 1). Elsevier EBooks, pp. 176–200.

By: R. Shirwaiker n , M. Purser  n & R. Wysk  n

Contributors: R. Shirwaiker n , M. Purser  n & R. Wysk  n

author keywords: hydrogels; biopaper; scaffolds; organ printing
topics (OpenAlex): 3D Printing in Biomedical Research; Electrospun Nanofibers in Biomedical Applications; Bone Tissue Engineering Materials
TL;DR: This chapter first reviews the developments, key characteristics, and applications of some commonly used and emerging hydrogel biomaterials, and discusses the compatibility between hydrogels and rapid prototyping (RP) scaffolding processes. (via Semantic Scholar)
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Source: ORCID
Added: September 6, 2019

2013 article

Determining Optimal Current Intensity and Duration for Electrically Activated Silver-Based Prophylactic Hip Implant Prototype Design

Tan, Z., Shirwaiker, R. A., & Orndoff, P. E. (2013, June 26). Volume 1B: Extremity; Fluid Mechanics; Gait; Growth, Remodeling, and Repair; Heart Valves; Injury Biomechanics; Mechanotransduction and Sub-Cellular Biophysics; MultiScale Biotransport; Muscle, Tendon and Ligament; Musculoskeletal Devices; Multiscale Mechanics; Thermal Medicine; Ocular Biomechanics; Pediatric Hemodynamics; Pericellular Phenomena; Tissue Mechanics; Biotransport Design and Devices; Spine; Stent Device Hemodynamics; Vascular Solid Mechanics; Student Paper and Design Competitions.

By: Z. Tan n, R. Shirwaiker n  & P. Orndoff n

Contributors: Z. Tan n, R. Shirwaiker n  & P. Orndoff n

topics (OpenAlex): Orthopedic Infections and Treatments; Orthopaedic implants and arthroplasty; Bacterial biofilms and quorum sensing
TL;DR: Preliminary in vitro and in vivo results have demonstrated the potency of silver-based OI as an effective local antibacterial therapy in osteomyelitis treatment with advantages over various antibiotics. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2013 article

Interdigitated silver-polymer-based antibacterial surface system activated by oligodynamic iontophoresis – An empirical characterization study

Shirwaiker, R. A., Wysk, R. A., Kariyawasam, S., Voigt, R. C., Carrion, H., & Nembhard, H. B. (2013, August 5). Biomedical Microdevices, Vol. 16, pp. 1–10.

By: R. Shirwaiker n , R. Wysk n, S. Kariyawasam *, R. Voigt*, H. Carrion * & H. Nembhard *

Contributors: R. Shirwaiker n , R. Wysk n, S. Kariyawasam *, R. Voigt*, H. Carrion * & H. Nembhard *

author keywords: Silver; Ions; Low intensity direct electric current (LIDC); Antibacterial surface
MeSH headings : Anti-Bacterial Agents / chemistry; Cross Infection / prevention & control; Enterococcus faecalis / drug effects; Escherichia coli / drug effects; Humans; Iontophoresis / methods; Polymers / chemistry; Pseudomonas aeruginosa / drug effects; Silver / chemistry; Staphylococcus aureus / drug effects
topics (OpenAlex): Nanoparticles: synthesis and applications; Bacterial biofilms and quorum sensing; Nanotechnology research and applications
TL;DR: The results indicate that given a constant total effective surface area, the surface system designed with micro-scale features and activated by 15 μA direct current will provide the most effective antibacterial prophylaxis. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 article

Nanomaterials and synergistic low‐intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices

Shirwaiker, R. A., Samberg, M. E., Cohen, P. H., Wysk, R. A., & Monteiro‐Riviere, N. A. (2013, January 17). Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology, Vol. 5, pp. 191–204.

By: R. Shirwaiker n , M. Samberg n, P. Cohen n , R. Wysk n & N. Monteiro‐Riviere n 

Contributors: R. Shirwaiker n , M. Samberg n, P. Cohen n , R. Wysk n & N. Monteiro-Riviere n 

MeSH headings : Animals; Electric Stimulation / methods; Equipment and Supplies; Humans; Nanostructures / therapeutic use; Nanostructures / ultrastructure; Nanotechnology / methods; Orthopedics; Prostheses and Implants
topics (OpenAlex): Nanoparticles: synthesis and applications; Bone Tissue Engineering Materials; Graphene and Nanomaterials Applications
TL;DR: While many nanomaterials have clearly demonstrated their ability to provide more effective implantable medical surfaces, further decisive investigations are necessary before they can translate into medically safe and commercially viable clinical applications. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2013 article

Regenerative medicine manufacturing

Industrial Engineer, Vol. 45, pp. 32–37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882976891&partnerID=MN8TOARS

By: R. Shirwaiker , Z. Tan & P. Cohen

Contributors: R. Shirwaiker , Z. Tan & P. Cohen

www.scopus.com
Source: ORCID
Added: September 6, 2019

2012 conference paper

A novel fabrication method for embedding metal structures into polymers for flexible electronics

62nd IIE Annual Conference and Expo 2012, 3212–3221. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900336522&partnerID=MN8TOARS

By: H. Carrion, S. Joshi, R. Shirwaiker  & S. Fonash

Contributors: H. Carrion, S. Joshi, R. Shirwaiker  & S. Fonash

www.scopus.com
Source: ORCID
Added: September 6, 2019

2012 conference paper

A process engineering perspective of scaffold fabrication methods in regenerative medicine: A review

62nd IIE Annual Conference and Expo 2012, 3096–3105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900330276&partnerID=MN8TOARS

By: G. Kazemi-Tutunchi, C. Wei, R. Shirwaiker  & J. Dong

Contributors: G. Kazemi-Tutunchi, C. Wei, R. Shirwaiker  & J. Dong

www.scopus.com
Source: ORCID
Added: September 6, 2019

2012 conference paper

A review of emerging industrial and systems engineering trends and future directions in biomanufacturing

62nd IIE Annual Conference and Expo 2012, 2354–2361. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900322032&partnerID=MN8TOARS

By: Z. Tan & R. Shirwaiker 

Contributors: Z. Tan & R. Shirwaiker 

www.scopus.com
Source: ORCID
Added: September 6, 2019

2012 article

Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications

Samberg, M. E., Tan, Z., Monteiro-Riviere, N. A., Orndorff, P. E., & Shirwaiker, R. A. (2012, December 15). Journal of Materials Science Materials in Medicine, Vol. 24, pp. 755–760.

By: M. Samberg n, Z. Tan*, N. Monteiro-Riviere n , P. Orndorff n & R. Shirwaiker n 

Contributors: M. Samberg n, Z. Tan*, N. Monteiro-Riviere n , P. Orndorff n & R. Shirwaiker n 

MeSH headings : Anti-Bacterial Agents; Biocompatible Materials; Equipment and Supplies; Escherichia coli / drug effects; Microbial Sensitivity Tests; Silver; Staphylococcus aureus / drug effects; Surface Properties
topics (OpenAlex): Bone Tissue Engineering Materials; Graphene and Nanomaterials Applications; Nanoparticles: synthesis and applications
TL;DR: The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo. (via Semantic Scholar)
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Added: August 6, 2018

2011 article

Contributions of TRIZ and axiomatic design to leanness in design: an investigation

Shirwaiker, R. A., & Okudan, G. E. (2011, January 1). Procedia Engineering, Vol. 9, pp. 730–735.

By: R. Shirwaiker*  & G. Okudan*

Contributors: R. Shirwaiker*  & G. Okudan*

topics (OpenAlex): Quality and Supply Management; Design Education and Practice; Product Development and Customization
Source: ORCID
Added: September 6, 2019

2011 conference paper

Effects of critical design parameters on antibacterial efficacy of a silver ions-based antibacterial surface system

61st Annual IIE Conference and Expo Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900320661&partnerID=MN8TOARS

By: R. Shirwaiker , R. Voigt & R. Wysk

Contributors: R. Shirwaiker , R. Voigt & R. Wysk

www.scopus.com
Source: ORCID
Added: September 6, 2019

2011 article

Micro-scale fabrication and characterization of a silver-polymer-based electrically activated antibacterial surface

Shirwaiker, R. A., Wysk, R. A., Kariyawasam, S., Carrion, H., & Voigt, R. C. (2011, January 18). Biofabrication, Vol. 3.

By: R. Shirwaiker* , R. Wysk n, S. Kariyawasam *, H. Carrion * & R. Voigt*

Contributors: R. Shirwaiker* , R. Wysk n, S. Kariyawasam *, H. Carrion * & R. Voigt*

MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Disinfection / instrumentation; Disinfection / methods; Microbial Viability / drug effects; Polymers / chemistry; Polymers / pharmacology; Silver / chemistry; Silver / pharmacology
topics (OpenAlex): Nanoparticles: synthesis and applications; Biosensors and Analytical Detection; Advanced Sensor and Energy Harvesting Materials
TL;DR: The fabrication methodology and characterization results for an electrically activated silver-polymer-based antibacterial surface with primary applications in preventing indirect contact transmission of infections and its antibacterial efficacy testing results show significant reductions in the number of viable organisms. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science
Added: August 6, 2018

2011 conference paper

Optimization of manufacturing operations using a new interactive computer-aided process planning program

61st Annual IIE Conference and Expo Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900313847&partnerID=MN8TOARS

By: Z. Yang, R. Shirwaiker  & R. Wysk

Contributors: Z. Yang, R. Shirwaiker  & R. Wysk

www.scopus.com
Source: ORCID
Added: September 6, 2019

2010 conference paper

Design of an electrically activated silver-based antibacterial surface system

IIE Annual Conference and Expo 2010 Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901037163&partnerID=MN8TOARS

By: R. Shirwaiker , R. Voigt & R. Wysk

Contributors: R. Shirwaiker , R. Voigt & R. Wysk

www.scopus.com
Source: ORCID
Added: September 6, 2019

2010 journal article

Developing an engineered antimicrobial/prophylactic system using electrically activated bactericidal metals

Journal of Materials Science: Materials in Medicine, 21(7), 2103–2114.

By: T. Fuller, R. Wysk*, C. Charumani*, M. Kennett*, W. Sebastiennelli, R. Abrahams*, R. Shirwaiker* , R. Voigt, P. Royer

Contributors: T. Fuller, R. Wysk*, C. Charumani*, M. Kennett*, W. Sebastiennelli, R. Abrahams*, R. Shirwaiker* , R. Voigt, P. Royer

MeSH headings : Anti-Bacterial Agents / pharmacology; Anti-Infective Agents / pharmacology; Electricity; Electrodes; Gels; Humans; Metals / pharmacology; Silver / pharmacology; Silver Compounds / pharmacology
topics (OpenAlex): Orthopedic Infections and Treatments; Bacterial biofilms and quorum sensing; Orthopaedic implants and arthroplasty
TL;DR: A surface treatment based on ionic emission to create an antibiotic environment that can significantly reduce RHD associated infections is proposed. (via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 6, 2019

2007 article

Triz and axiomatic design: a review of case-studies and a proposed synergistic use

Shirwaiker, R. A., & Okudan, G. E. (2007, July 2). Journal of Intelligent Manufacturing, Vol. 19, pp. 33–47.

By: R. Shirwaiker*  & G. Okudan*

Contributors: R. Shirwaiker*  & G. Okudan*

author keywords: TRIZ; Axiomatic Design
topics (OpenAlex): Design Education and Practice; Product Development and Customization; Manufacturing Process and Optimization
TL;DR: Practical applications of TRIZ and AD in solving industrial problems related to manufacturing and designing are reviewed and a new approach of applying these two techniques concurrently to solve a problem to attain efficiency and quality in the problem solving process is proposed. (via Semantic Scholar)
Source: ORCID
Added: September 6, 2019

2007 article

USING TRIZ AND AXIOMATIC DESIGN SYNERGISTICALLY: A CASE STUDY

SHIRWAIKER, R. O. H. A. N. A., & OKUDAN, G. Ü. L. E. (2007, June 1). International Journal of Innovation and Technology Management, Vol. 4, pp. 155–170.

By: R. Shirwaiker*  & G. Okudan*

Contributors: R. Shirwaiker*  & G. Okudan*

author keywords: TRIZ; axiomatic design; synergistic problem solving approach
topics (OpenAlex): Design Education and Practice; Product Development and Customization; Systems Engineering Methodologies and Applications
TL;DR: This paper demonstrates the effectiveness of the synergistic approach through a manufacturing related case-study and considers the importance of validation of engineering models, based on review of design engineering validation literature. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure (OpenAlex)
Source: ORCID
Added: September 6, 2019

2006 article

A Multi-Stage Problem Formulation for Concept Selection for Improved Product Design

Okudan, G., & Shirwaiker, R. (2006, July 1). Portland International Conference on Management of Engineering and Technology, Vol. 6, pp. 2528–2538.

By: G. Okudan* & R. Shirwaiker* 

Contributors: G. Okudan* & R. Shirwaiker* 

topics (OpenAlex): Multi-Criteria Decision Making; Advanced Multi-Objective Optimization Algorithms; Process Optimization and Integration
TL;DR: A new concept selection method is proposed and its application is demonstrated and the utility theory based proposed method formulates the concept selection problem as a multi-stage decision. (via Semantic Scholar)
Source: ORCID
Added: September 6, 2019

2006 conference paper

An investigation on the effectiveness of design ideation using TRIZ

Proceedings of the ASME Design Engineering Technical Conference, 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751337036&partnerID=MN8TOARS

By: G. Okudan, M. Ogot & R. Shirwaiker 

Contributors: G. Okudan, M. Ogot & R. Shirwaiker 

www.scopus.com
Source: ORCID
Added: September 6, 2019

2006 article

TRIZ and Axiomatic Design: A Review of Manufacturing Case-Studies&Their Compatibility

Shirwaiker, R., & Okudan, G. (2006, July 1). Portland International Conference on Management of Engineering and Technology, Vol. 6, pp. 2510–2520.

By: R. Shirwaiker*  & G. Okudan*

Contributors: R. Shirwaiker*  & G. Okudan*

topics (OpenAlex): Design Education and Practice; Product Development and Customization; Manufacturing Process and Optimization
TL;DR: Practical applications of TRIZ and AD in solving industrial problems related to designing and manufacturing are reviewed to propose that application of these two techniques synergistically to solve a problem will increase the efficiency and quality of the problem solving process. (via Semantic Scholar)
Source: ORCID
Added: September 6, 2019

Employment

Updated: May 12th, 2025 22:13

2025 - present

North Carolina State University Raleigh, North Carolina, US
James T. Ryan Distinguished Professor Industrial & Systems Engineering

2024 - present

North Carolina State University Raleigh, North Carolina, US
Co-Director & Chief Scientific Officer Bezos Center for Sustainable Protein at NC State

2022 - present

North Carolina State University Raleigh, North Carolina, US
Professor and University Faculty Scholar Industrial & Systems Engineering

2021 - present

North Carolina State University Raleigh, North Carolina, US
Associate Faculty Mechanical and Aerospace Engineering

2019 - present

North Carolina State University Raleigh, North Carolina, US
Associate Director Comparative Medicine Institute

2012 - present

North Carolina State University Raleigh, NC, US
Associate Faculty Biomedical Engineering

2017 - 2022

NC State University Raleigh, NC, US
Associate Professor Industrial & Systems Engineering

2011 - 2017

North Carolina State University Raleigh, NC, US
Assistant Professor Industrial & Systems Engineering

Education

Updated: November 9th, 2017 12:13

2007 - 2011

Pennsylvania State University University Park, PA, US
PhD Industrial & Manufacturing Engineering

2005 - 2007

Pennsylvania State University University Park, PA, US
MS Industrial & Manufacturing Engineering

2001 - 2005

University of Mumbai Mumbai, Maharashtra, IN
BE Production Engineering

Funding History

Funding history based on the linked ORCID record. Updated: May 12th, 2025 22:17

grant March 1, 2025 - February 1, 2029
Bezos Center for Sustainable Protein at NC State
Bezos Earth Fund
grant September 1, 2022 - August 31, 2025
MRI: Acquisition of a Multi-modal, High-resolution 4D Bioprinting Platform for Multidisciplinary Research and Workforce Training at NC State
Directorate for Engineering
grant July 1, 2021 - June 30, 2026
Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant September 1, 2020 - August 31, 2022
Engineering Multi-scale Structure of the Knee Meniscus using Advanced 3D Nonwovens Fabrication
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant September 1, 2017 - August 1, 2021
Collaborative Research: 3D-Biofabrication of hASC-based Biomimetic Osteochondral Tissue and the Role of Extracellular Calcium Receptor
National Science Foundation
grant June 1, 2017 - May 31, 2023
CAREER: Ultrasound-Assisted Biofabrication Of Biomimetic Soft Tissue Constructs With Aligned Fiber Organization
Directorate for Engineering
grant June 1, 2017 - May 31, 2022
CAREER: Ultrasound-Assisted Biofabrication Of Biomimetic Soft Tissue Constructs With Aligned Fiber Organization
National Science Foundation
grant June 1, 2016 - November 30, 2019
Real-time Monitoring of Critical Quality Attributes of Bioprinted Constructs in Manufacturing of Engineered Tissues
Directorate for Engineering

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