Works (60)
Updated: April 4th, 2024 04:55
2022 journal article
Investigating dielectric spectroscopy and soft sensing for nondestructive quality assessment of engineered tissues
BIOSENSORS & BIOELECTRONICS, 216.
author keywords: Biofabrication; Dielectric spectroscopy; Non-destructive quality monitoring; Soft sensing; Tissue engineering
MeSH headings : Biosensing Techniques; Dielectric Spectroscopy / methods; Gelatin; Humans; Methacrylates; Tissue Engineering / methods
TL;DR:
A new soft-sensing approach with non-destructive dielectric spectroscopy (DS) that synergistically utilizes inline sensor data and predictive analytics to estimate unmeasured TEMP quality profiles is investigated, and a bilinear basis mixed model (BBMM) is developed as a soft sensor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 18, 2022
2022 journal article
Multiphase CFD Modeling and Experimental Validation of Polymer and Attenuating Air Jet Interactions in Nonwoven Annular Melt Blowing
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 61(37), 13962–13971.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022
2022 article
Multiscale Anisotropic Tissue Biofabrication via Bulk Acoustic Patterning of Cells and Functional Additives in Hybrid Bioinks
Chansoria, P., Asif, S., Gupta, N., Piedrahita, J., & Shirwaiker, R. A. (2022, January 27). ADVANCED HEALTHCARE MATERIALS, Vol. 1.
author keywords: 3D cell patterning; biofabrication; bioprinting; GelMA; hybrid bioinks; standing bulk acoustic waves; ultrasound
MeSH headings : Acoustics; Anisotropy; Bioprinting; Gelatin / chemistry; Humans; Hydrogels / chemistry; Methacrylates; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR:
A highly versatile ultrasound‐assisted biofabrication (UAB) approach is demonstrated that utilizes radiation forces generated by superimposing ultrasonic bulk acoustic waves to rapidly organize arrays of cells and other biomaterial additives within single and multilayered hydrogel constructs.
(via Semantic Scholar)
www.ncbi.nlm.nih.gov (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
9. Industry, Innovation and Infrastructure
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022
2021 article
Biofabricated 3D in vitro model of fibrosis-induced abnormal hepatoblast/biliary progenitors' expansion of the developing liver
Brovold, M., Keller, D., Devarasetty, M., Dominijanni, A., Shirwaiker, R., & Soker, S. (2021, June 5). BIOENGINEERING & TRANSLATIONAL MEDICINE, Vol. 12.
author keywords: 3D organoids; biliary development; fibrosis; HepaRG; hepatic stellate cell
TL;DR:
A simple yet robust model that recapitulates physico‐mechanical and cellular aspects of fibrosis mediated via hepatic stellate cells (HSCs) and their effects on biliary progenitor cells is developed to benefit pediatric patients that suffer from the biliary dysgenesis associated with a multitude of congenital liver diseases.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 28, 2021
2021 journal article
Cell-Laden Nanocellulose/Chitosan-Based Bioinks for 3D Bioprinting and Enhanced Osteogenic Cell Differentiation
ACS APPLIED BIO MATERIALS, 4(3), 2342–2353.
author keywords: chitosan-based hydrogel; cellulose nanocrystal; bioink; osteogenic differentiation; bioprinting
MeSH headings : 3T3 Cells; Animals; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Bioprinting; Cell Differentiation / drug effects; Cells, Cultured; Cellulose / chemistry; Cellulose / pharmacology; Chitosan / chemistry; Chitosan / pharmacology; Ink; Materials Testing; Mice; Nanoparticles / chemistry; Osteogenesis / drug effects; Particle Size
TL;DR:
The versatility of this CNCs-incorporated chitosan hydrogel makes it attractive as a bioink for 3D bioprinting to engineer scaffolds for bone tissue engineering and other therapeutic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021
2021 journal article
Characterizing the Effects of Synergistic Thermal and Photo-Cross-Linking during Biofabrication on the Structural and Functional Properties of Gelatin Methacryloyl (GeIMA) Hydrogels
ACS BIOMATERIALS SCIENCE & ENGINEERING, 7(11), 5175–5188.
author keywords: GelMA; thermo-reversible cross-linking; photo-cross-linking; biofabrication; tissue engineering; CryoSEM; qPCR
MeSH headings : Biocompatible Materials; Gelatin; Humans; Hydrogels; Methacrylates; Tissue Engineering
TL;DR:
The finding that hydrogels processed at higher temperature possessed lower structural fidelity but resulted in more cell elongation and greater anisotropy over time demonstrate the significant impact of GelMA material formulation and processing conditions on the structural and functional properties of the hydrogel.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 29, 2021
2021 article
Fabrication of drug-loaded ultrafine polymer fibers via solution blowing and their drug release kinetics
49TH SME NORTH AMERICAN MANUFACTURING RESEARCH CONFERENCE (NAMRC 49, 2021), Vol. 53, pp. 128–135.
author keywords: solution blowing; biofabrication; fibers; doxycycline; drug release
Sources: Web Of Science, NC State University Libraries
Added: October 24, 2022
2021 article
Non-destructive quality monitoring of 3D printed tissue scaffolds via dielectric impedance spectroscopy and supervised machine learning
49TH SME NORTH AMERICAN MANUFACTURING RESEARCH CONFERENCE (NAMRC 49, 2021), Vol. 53, pp. 636–643.
author keywords: biofabrication; non-destructive quality monitoring; supervised machine learning; dielectric impedance spectroscopy; tissue engineering
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2022
2021 review
Process hybridization schemes for multiscale engineered tissue biofabrication
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 13(2).
author keywords: biofabrication; biomimetics; hybrid processes; tissue engineering and regenerative medicine
MeSH headings : Biomimetics; Nanotechnology; Tissue Engineering; Tissue Scaffolds
TL;DR:
This work discusses recent literature in this domain and attempts to equip the reader with the understanding of selecting appropriate processes that can harmonize toward creating engineered tissues with appropriate multiscale structure-function properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 9, 2020
2021 journal article
Steroid eluting biocompatible stent for subglottic stenosis
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 278(4), 1153–1158.
author keywords: Subglottic stenosis; Tracheal stent; Dissolvable; Endoscopic intervention
MeSH headings : Animals; Constriction, Pathologic; Drug-Eluting Stents; Laryngostenosis / surgery; Rabbits; Stents; Steroids; Trachea
TL;DR:
This proof-of-concept project is an initial step to demonstrate and create a novel stent in the treatment of subglottic stenosis that applies expansile force on the trachea, elutes steroids and dissolves over time.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 25, 2021
2021 article
The evaluation of a multiphasic 3D-bioplotted scaffold seeded with adipose derived stem cells to repair osteochondral defects in a porcine model
Nordberg, R. C., Huebner, P., Schuchard, K. G., Mellor, L. F., Shirwaiker, R. A., Loboa, E. G., & Spang, J. T. (2021, June 10). JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, Vol. 6.
author keywords: in vivo; osteochondral; stem cells; tissue engineering; 3D-printing
MeSH headings : Animals; Cartilage, Articular / injuries; Stem Cells; Swine; Swine, Miniature; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
Overall, scaffold groups repaired the defect more successfully than an open lesion but achieved limited repair in the cartilage region, indicating that this approach holds potential to treat focal cartilage lesions in a highly personalized manner using a human patient's own ASC cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 21, 2021
2020 journal article
3D bioprinting of anisotropic engineered tissue constructs with ultrasonically induced cell patterning
ADDITIVE MANUFACTURING, 32.
author keywords: Bioprinting; Ultrasound; Biomimicry; Standing bulk acoustic wave (SBAW); Alginate; GelMA
TL;DR:
This study describes a new bioprinting technique that uses ultrasonic standing bulk acoustic waves (SBAW) to organize cells into controllable anisotropic patterns within viscous bioinks while maintaining high cell viability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 8, 2020
2020 journal article
Effects of Autoclaving, EtOH, and UV Sterilization on the Chemical, Mechanical, Printability, and Biocompatibility Characteristics of Alginate
ACS BIOMATERIALS SCIENCE & ENGINEERING, 6(9), 5191–5201.
author keywords: hydrogels; tissue engineering and regenerative medicine; biofabrication; printability; human adipose-derived stem cells (hASC); nuclear magnetic resonance spectroscopy
MeSH headings : Alginates; Anti-Bacterial Agents; Ethanol; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Sterilization
TL;DR:
The autoclaving process, while demonstrating broad spectrum sterility effectiveness, also resulted in most notable changes in alginate's key properties, which significantly reduced the molecular weight and polydispersity index, as determined via gel permeation chromatography, as well as the dynamic viscosity ofAlginate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020
2020 journal article
Experimental Characterization and Finite Element Modeling of the Effects of 3D Bioplotting Process Parameters on Structural and Tensile Properties of Polycaprolactone (PCL) Scaffolds
Applied Sciences, 10(15), 5289.
author keywords: 3D Bioplotting; scaffolds; finite element analysis; tensile strength; PCL
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: August 4, 2020
2020 journal article
High-Throughput Manufacture of 3D Fiber Scaffolds for Regenerative Medicine
TISSUE ENGINEERING PART C-METHODS, 26(7), 364–374.
author keywords: 3D printing; melt blowing; fibers; scaffolds
MeSH headings : Animals; Biocompatible Materials / chemistry; Dogs; Hernia / therapy; Herniorrhaphy / methods; Polymers / chemistry; Printing, Three-Dimensional / instrumentation; Regenerative Medicine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The 3DMB system described in this study is modified from larger nonwovens manufacturing machinery to accommodate the lower volume, high-cost polymers used for tissue engineering and implantable biomedical devices and has a fiber collection component that uses adaptable robotics to create scaffolds with predetermined geometries.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
Investigation of multiphasic 3D-bioplotted scaffolds for site-specific chondrogenic and osteogenic differentiation of human adipose-derived stem cells for osteochondral tissue engineering applications
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 108(5), 2017–2030.
author keywords: 3D-printing; chondrogenic differentiation; human adipose derived stem cells; osteochondral; osteogenic differentiation
MeSH headings : Adipose Tissue / metabolism; Biocompatible Materials / chemistry; Bone and Bones; Calcium Phosphates / chemistry; Calcium Phosphates / metabolism; Cartilage, Articular / metabolism; Cell Differentiation; Cells, Cultured; Chondrogenesis / physiology; Collagen Type I / genetics; Collagen Type I / metabolism; Extracellular Matrix / chemistry; Extracellular Matrix / metabolism; Humans; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / metabolism; Osteogenesis / physiology; Polyesters / chemistry; Polyesters / metabolism; Printing, Three-Dimensional; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR:
A scaffold that would induce site‐specific osteogenic and chondrogenic differentiation of human adipose‐derived stem cells (hASC) to generate a full osteochondral implant is created and holds great promise as cartilage morbidity is minimized since autologous cartilage harvest is not required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 6, 2020
2020 journal article
Mechanical properties of tissue formed in vivo are affected by 3D-bioplotted scaffold microarchitecture and correlate with ECM collagen fiber alignment
CONNECTIVE TISSUE RESEARCH, 61(2), 190–204.
author keywords: 3D printing; atomic force microscopy; elastic modulus; tissue engineering; tissue scaffolds
MeSH headings : Animals; Bioprinting; Collagen / chemistry; Extracellular Matrix / chemistry; Male; Polyesters / chemistry; Printing, Three-Dimensional; Rats; Rats, Sprague-Dawley; Tissue Engineering; Tissue Scaffolds / chemistry
TL;DR:
The findings demonstrate the significant effects of 3D-bioplotted scaffold microarchitectures in the organization and sub-tissue-level mechanical properties of ECM in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019
2020 journal article
Review: Modeling in Situ Liver Cancer
Annals of Gastroenterology and Digestive Disorders. https://www.somatopublications.com/review-modeling-in-situ-liver-cancer.pdf
Source: ORCID
Added: May 28, 2021
2020 article
Ultrasound-assisted vat photopolymerization 3D printing of preferentially organized carbon fiber reinforced polymer composites
Asif, S., Chansoria, P., & Shirwaiker, R. (2020, August). JOURNAL OF MANUFACTURING PROCESSES, Vol. 56, pp. 1340–1343.
author keywords: Additive manufacturing; Vat photopolymerization; Ultrasound; Bulk acoustic wave; Carbon fiber reinforced composites
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 1, 2021
2019 journal article
Characterizing the Process Physics of Ultrasound-Assisted Bioprinting
SCIENTIFIC REPORTS, 9.
TL;DR:
This work describes the underlying process physics and develops and validate computational models to determine the effects of ultrasound process parameters on the relevant temperature, pressure distribution, and alignment time characteristics and demonstrates the UAB of bilayered constructs with parallel (0°–0°) and orthogonal cellular alignment across layers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2019
2019 journal article
The Ion Delivery Manner Influences the Antimicrobial Efficacy of Silver Oligodynamic Iontophoresis
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 39(4), 622–631.
author keywords: Oligodynamic iontophoresis; Silver ion; Antimicrobial activities; Electrical activation
TL;DR:
The antimicrobial activities of the silver-based iontophoresis prototype was more sensitive to current duration than current intensity, and the marginal antimicrobial efficacy of the device decreased as the current intensity increased.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 5, 2019
2019 journal article
Ultrasound-assisted biofabrication and bioprinting of preferentially aligned three-dimensional cellular constructs
BIOFABRICATION, 11(3).
author keywords: biofabrication; bioprinting; ultrasound; tissue engineering; 3D acoustic patterning; standing bulk acoustic waves; 3D cell manipulation
MeSH headings : Acoustics; Adipose Tissue / cytology; Alginates / pharmacology; Bioprinting / methods; Cell Survival / drug effects; Finite Element Analysis; Humans; Ink; Menisci, Tibial / drug effects; Pressure; Printing, Three-Dimensional; Stem Cells / cytology; Stem Cells / drug effects; Tissue Scaffolds / chemistry; Transducers; Ultrasonics; Viscosity
TL;DR:
A new acoustophoretic three-dimensional (3D) biofabrication approach that utilizes radiation forces generated by superimposing ultrasonic bulk acoustic waves (BAW) to preferentially organize cellular arrays within single and multi-layered hydrogel constructs is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 20, 2019
2018 journal article
Label free process monitoring of 3D bioprinted engineered constructs via dielectric impedance spectroscopy
BIOFABRICATION, 10(3).
author keywords: FDA PAT; Process Analytical Technology; bioprinting process parameters; biofabrication process monitoring; quality assessment
MeSH headings : Bioprinting / standards; Cell Line; Cell Survival / physiology; Cells, Cultured; Dielectric Spectroscopy / methods; Humans; Materials Testing / methods; Printing, Three-Dimensional; Stem Cells / cytology; Tissue Engineering / standards
TL;DR:
The findings of this study support the use of dielectric impedance spectroscopy as a label-free and non-destructive method to characterize the critical quality attributes of bioprinted constructs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Antibacterial efficacy and cytotoxicity of low intensity direct current activated silver-titanium implant system prototype
BIOMETALS, 30(1), 113–125.
Contributors: Z. Tan n, E. Havell n, P. Orndorff n & n
author keywords: Low intensity direct current; Silver-titanium implant; Orthopaedic application; Antimicrobial efficacy; Cytotoxicity
MeSH headings : Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Cell Proliferation / drug effects; Ions / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / pathogenicity; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / drug therapy; Staphylococcal Infections / microbiology; Titanium / chemistry; Titanium / pharmacology
TL;DR:
The in vitro antibacterial efficacy and cytotoxicity of a low intensity direct current (LIDC)-activated silver–titanium implant system prototype designed for localized generation and delivery of silver ions at the implantation site showed high antimicrobial efficacy against MRSA, but was also toxic to human cells immediately surrounding the electrodes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Effects of 3D-bioplotted polycaprolactone scaffold geometry on human adipose-derived stem cell viability and proliferation
RAPID PROTOTYPING JOURNAL, 23(3), 534–542.
author keywords: 3D-Bioplotting; Human adipose-derived stem cells; Polycaprolactone; Tissue engineering scaffolds
TL;DR:
The design with the lowest porosity had the highest compression modulus after 14 days of culture, but resulted in the lowest hASC viability, which provided the basis for future studies which will use this optimal scaffold design to develop constructs for hASC-based osteochondral tissue engineering applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2017 journal article
Engineering 3D-Bioplotted scaffolds to induce aligned extracellular matrix deposition for musculoskeletal soft tissue replacement
CONNECTIVE TISSUE RESEARCH, 58(3-4), 342–354.
Contributors: P. Warren n, P. Huebner n, J. Spang*, n & M. Fisher n
author keywords: Biofabrication; meniscus; tissue engineering; scaffold; 3D printing
MeSH headings : Animals; Cell Count; Cell Shape; Collagen / metabolism; Extracellular Matrix / metabolism; Imaging, Three-Dimensional; Male; Musculoskeletal Physiological Phenomena; Rats, Sprague-Dawley; Regeneration / physiology; Sus scrofa; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The ability to use interstrand spacing as a means of controlling the formation of aligned collagen in vivo was demonstrated, which helps establish a design space for scaffold-based meniscus tissue engineering.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
Fabrication and Evaluation of Electrospun, 3D-Bioplotted, and Combination of Electrospun/3D-Bioplotted Scaffolds for Tissue Engineering Applications
BIOMED RESEARCH INTERNATIONAL, 2017.
Contributors: L. Mellor n, P. Huebner n, S. Cai n, M. Mohiti-Asli n, M. Taylor n, J. Spang*, n , E. Loboa*
MeSH headings : Animals; Cells, Cultured; Extracellular Matrix / chemistry; Humans; Nanofibers / chemistry; Nanofibers / therapeutic use; Polyesters / chemistry; Polyesters / therapeutic use; Porosity; Printing, Three-Dimensional; Swine; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR:
The approach combining these two commonly used scaffold fabrication technologies allows for the creation of a scaffold with more close resemblance to heterogeneous tissue architecture, holding great potential for tissue engineering and regenerative medicine applications of osteochondral tissue and other heterogeneous tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2017 conference paper
Investigating dielectric impedance spectroscopy as a non-destructive quality assessment tool for 3D cellular constructs
Proceedings of the ASME 12th International Manufacturing Science and Engineering Conference - 2017, vol 4.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
2017 conference paper
Investigating dielectric impedance spectroscopy as a non-destructive quality assessment tool for 3D cellular constructs
ASME 2017 12th International Manufacturing Science and Engineering Conference, MSEC 2017 collocated with the JSME/ASME 2017 6th International Conference on Materials and Processing, 4.
Source: ORCID
Added: September 6, 2019
2017 conference paper
Non-destructive quality assessment of 3D-biofabricated constructs using dielectric impedance spectroscopy
67th Annual Conference and Expo of the Institute of Industrial Engineers 2017, 1846–1851. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030973322&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2016 journal article
3D-Bioprinting of Polylactic Acid (PLA) Nanofiber–Alginate Hydrogel Bioink Containing Human Adipose-Derived Stem Cells
ACS Biomaterials Science & Engineering, 2(10), 1732–1742.
Contributors: L. Narayanan n, P. Huebner n, M. Fisher n, J. Spang*, B. Starly n & n
author keywords: bioprinting; knee meniscus; alginate; nanofibers; adipose-derived stem cells; musculoskeletal soft tissue
TL;DR:
This study focuses on the development and proof-of-concept assessment of a fibrous bioink composed of alginate hydrogel, polylactic acid nanofibers, and human adipose-derived stem cells for bioprinting such tissue constructs and shows that the nanofiber-reinforced bioink allowed higher levels of cell proliferation within biopprinted strands.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Effects of Electrically Activated Silver-Titanium Implant System Design Parameters on Time-Kill Curves Against Staphylococcus aureus
JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING, 36(3), 325–333.
Contributors: Z. Tan n, G. Xu n, P. Orndorff n & n
author keywords: Antimicrobial efficacy; Orthopaedic implants; Ionic silver; Post-operative infections; Design parameters
TL;DR:
The in vitro antimicrobial efficacy of a silver-based prophylactic system for orthopaedic implant applications is characterized and provides a reference of design parameters for future product engineering.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
Evaluation of silver-titanium implants activated by low intensity direct current for orthopedic infection control: An in vitro and in vivo study
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 104(5), 1023–1031.
Contributors: D. Cavanaugh*, Z. Tan n, J. Norris*, A. Hardee n, P. Weinhold n, L. Dahners*, P. Orndorff n, n
author keywords: prosthetic infection; oligodynamic silver; antimicrobial implant; electrical activation
MeSH headings : Animals; Female; Femur / microbiology; Femur / surgery; Implants, Experimental; Rats; Rats, Sprague-Dawley; Silver / chemistry; Silver / pharmacology; Staphylococcal Infections / prevention & control; Staphylococcus aureus / growth & development; Titanium / chemistry; Titanium / pharmacology
TL;DR:
In vivo, none of the four groups were able to prevent wound infection, but the experimental group resulted in reduced colonization, and the antimicrobial potential of LIDC-activated Ag-Ti implants is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
In vitro characterization of design and compressive properties of 3D-biofabricated/decellularized hybrid grafts for tracheal tissue engineering
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS, 59, 572–585.
Contributors: C. Johnson *, P. Sheshadri n, J. Ketchum*, L. Narayanan n, P. Weinberger* & n
author keywords: Trachea; Scaffolds; Tissue engineering; Decellularized ECM; Biofabrication
MeSH headings : Animals; Cartilage; Compressive Strength; Prosthesis Design; Swine; Tissue Engineering; Tissue Scaffolds; Trachea
TL;DR:
The data support the possibility that future embodiments using a hybrid graft approach may reduce the need for intraluminal stenting in tracheal transplant recipients, and show that the resistance to compression offered by the hybrid grafts created using gamma radiation sterilized scaffolds was comparable to that of fresh trachesal segments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 book
3D Bioprinting Techniques
In 3D Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine (pp. 57–77).
TL;DR:
The single biggest advantage of 3D bioprinting is the ability to digitally define the tissue construct of interest and reproduce the physical 3D structure through automated techniques and at resolutions not possible through any conventional photolithography techniques.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2019
2015 journal article
A Clinical Perspective on Musculoskeletal Infection Treatment Strategies and Challenges
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS, 23, S44–S54.
Contributors: n , B. Springer n, M. Spangehl n, G. Garrigues n, D. Lowenberg n, D. Garras n, J. Yoo n, P. Pottinger n
MeSH headings : Arthritis, Infectious / etiology; Arthritis, Infectious / prevention & control; Arthritis, Infectious / therapy; Arthroplasty, Replacement / adverse effects; Arthroplasty, Replacement / instrumentation; Bone Diseases, Infectious / etiology; Bone Diseases, Infectious / prevention & control; Bone Diseases, Infectious / therapy; Humans; Joint Prosthesis / trends; Nanotechnology / trends; Prosthesis-Related Infections / prevention & control; Prosthesis-Related Infections / therapy; Surgical Wound Infection / etiology; Surgical Wound Infection / prevention & control; Surgical Wound Infection / therapy
TL;DR:
Novel prevention methods, such as nanotechnology and the introduction of antibiotic-coated implants, may aid in the prevention and early treatment of periprosthetic joint infections with goals of improved eradication rates and maintaining patient mobility and satisfaction.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Alginate Microspheroid Encapsulation and Delivery of MG-63 Cells Into Polycaprolactone Scaffolds: A New Biofabrication Approach for Tissue Engineering Constructs
Journal of Nanotechnology in Engineering and Medicine, 6(2).
Contributors: L. Narayanan n, A. Kumar n, Z. Tan n, S. Bernacki n, B. Starly n & n
TL;DR:
A new cell delivery approach utilizing deposition of hydrogel-cell encapsulated microspheroids into polycaprolactone (PCL) scaffolds to improve the seeding efficiency is investigated and the role and critical challenges to be addressed are highlighted to successfully utilize 3D-bioprinting for microencapsulated cell delivery.
(via Semantic Scholar)
Sources: ORCID, Crossref, NC State University Libraries
Added: September 6, 2019
2015 journal article
Characterization of material-process-structure interactions in the 3D Bioplotting of Polycaprolactone
3D Printing and Additive Manufacturing, 2(1), 20–31.
TL;DR:
The relationship between PCL dynamic viscosity and extrusion temperature during bioplotting was determined using rheological measurements and the ANOVA results demonstrated that the strand widt strength was higher than expected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 6, 2019
2015 journal article
Effects of cathode design parameters on in vitro antimicrobial efficacy of electrically-activated silver-based iontophoretic system
Journal of Materials Science: Materials in Medicine, 26(1), 1–10.
MeSH headings : Anti-Infective Agents / chemistry; Aspergillus flavus / drug effects; Diffusion; Electrochemistry / methods; Electrodes; Equipment Design; Escherichia coli / drug effects; Iontophoresis / methods; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Silver / chemistry; Staphylococcus aureus / drug effects; Streptococcus agalactiae / drug effects; Titanium / chemistry
TL;DR:
The ability to alter the cathode material and related design parameters in order to minimize the silver usage in the system without adversely affecting its antimicrobial efficacy is demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 6, 2019
2015 journal article
Manufacturing Road Map for Tissue Engineering and Regenerative Medicine Technologies
STEM CELLS TRANSLATIONAL MEDICINE, 4(2), 130–135.
Contributors: J. Hunsberger*, O. Harrysson n , n , B. Starly n , R. Wysk n, P. Cohen n , J. Allickson*, J. Yoo *, A. Atala*
MeSH headings : Biological Specimen Banks; Drug Industry / methods; Drug Industry / organization & administration; Humans; Regenerative Medicine / methods; Regenerative Medicine / organization & administration; Tissue Engineering / methods; Translational Research, Biomedical / methods; Translational Research, Biomedical / organization & administration
TL;DR:
A road map for developing the manufacturing infrastructure, resources, standards, capabilities, education, training, and workforce development to realize the promise of TERM is outlined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Interdigitated silver-polymer-based antibacterial surface system activated by oligodynamic iontophoresis - An empirical characterization study
BIOMEDICAL MICRODEVICES, 16(1), 1–10.
Contributors: n , R. Wysk n, S. Kariyawasam *, R. Voigt*, H. Carrion * & H. Nembhard*
author keywords: Silver; Ions; Low intensity direct electric current (LIDC); Antibacterial surface
MeSH headings : Anti-Bacterial Agents / chemistry; Cross Infection / prevention & control; Enterococcus faecalis / drug effects; Escherichia coli / drug effects; Humans; Iontophoresis / methods; Polymers / chemistry; Pseudomonas aeruginosa / drug effects; Silver / chemistry; Staphylococcus aureus / drug effects
TL;DR:
The results indicate that given a constant total effective surface area, the surface system designed with micro-scale features and activated by 15 μA direct current will provide the most effective antibacterial prophylaxis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 book
Scaffolding hydrogels for rapid prototyping based tissue engineering
In Rapid Prototyping of Biomaterials: Principles and Applications (pp. 176–200).
author keywords: hydrogels; biopaper; scaffolds; organ printing
TL;DR:
This chapter first reviews the developments, key characteristics, and applications of some commonly used and emerging hydrogel biomaterials, and discusses the compatibility between hydrogels and rapid prototyping (RP) scaffolding processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: ORCID
Added: September 6, 2019
2013 journal article
Biocompatibility analysis of an electrically-activated silver-based antibacterial surface system for medical device applications
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 24(3), 755–760.
Contributors: M. Samberg n, Z. Tan*, N. Monteiro-Riviere n , P. Orndorff n & *
MeSH headings : Anti-Bacterial Agents; Biocompatible Materials; Equipment and Supplies; Escherichia coli / drug effects; Microbial Sensitivity Tests; Silver; Staphylococcus aureus / drug effects; Surface Properties
TL;DR:
The study concluded that the technological applications of the surface system for medical devices and surgical tools, which contact human tissues for less than 1.5 h, are expected to be self-sterilizing without causing toxicity in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 conference paper
Determining optimal current intensity and duration for electrically activated silver-based prophylactic hip implant prototype design
ASME 2013 Summer Bioengineering Conference, SBC 2013, 1 B.
Contributors: Z. Tan n, n & P. Orndoff n
TL;DR:
Preliminary in vitro and in vivo results have demonstrated the potency of silver-based OI as an effective local antibacterial therapy in osteomyelitis treatment with advantages over various antibiotics.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2013 review
Nanomaterials and synergistic low-intensity direct current (LIDC) stimulation technology for orthopedic implantable medical devices
[Review of ]. WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY, 5(3), 191–204.
Contributors: n , M. Samberg n, P. Cohen n , R. Wysk n & N. Monteiro-Riviere n
MeSH headings : Animals; Electric Stimulation / methods; Equipment and Supplies; Humans; Nanostructures / therapeutic use; Nanostructures / ultrastructure; Nanotechnology / methods; Orthopedics; Prostheses and Implants
TL;DR:
While many nanomaterials have clearly demonstrated their ability to provide more effective implantable medical surfaces, further decisive investigations are necessary before they can translate into medically safe and commercially viable clinical applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2013 article
Regenerative medicine manufacturing
Industrial Engineer, Vol. 45, pp. 32–37. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882976891&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2012 conference paper
A novel fabrication method for embedding metal structures into polymers for flexible electronics
62nd IIE Annual Conference and Expo 2012, 3212–3221. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900336522&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2012 conference paper
A process engineering perspective of scaffold fabrication methods in regenerative medicine: A review
62nd IIE Annual Conference and Expo 2012, 3096–3105. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900330276&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2012 conference paper
A review of emerging industrial and systems engineering trends and future directions in biomanufacturing
62nd IIE Annual Conference and Expo 2012, 2354–2361. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900322032&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2011 conference paper
Contributions of TRIZ and axiomatic design to leanness in design: An investigation
Procedia Engineering, 9, 730–735.
Source: ORCID
Added: September 6, 2019
2011 conference paper
Effects of critical design parameters on antibacterial efficacy of a silver ions-based antibacterial surface system
61st Annual IIE Conference and Expo Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900320661&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2011 journal article
Micro-scale fabrication and characterization of a silver-polymer-based electrically activated antibacterial surface
BIOFABRICATION, 3(1).
Contributors: * , R. Wysk n, S. Kariyawasam *, H. Carrion * & R. Voigt*
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Disinfection / instrumentation; Disinfection / methods; Microbial Viability / drug effects; Polymers / chemistry; Polymers / pharmacology; Silver / chemistry; Silver / pharmacology
TL;DR:
The fabrication methodology and characterization results for an electrically activated silver-polymer-based antibacterial surface with primary applications in preventing indirect contact transmission of infections and its antibacterial efficacy testing results show significant reductions in the number of viable organisms.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science
Added: August 6, 2018
2011 conference paper
Optimization of manufacturing operations using a new interactive computer-aided process planning program
61st Annual IIE Conference and Expo Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900313847&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2010 conference paper
Design of an electrically activated silver-based antibacterial surface system
IIE Annual Conference and Expo 2010 Proceedings. http://www.scopus.com/inward/record.url?eid=2-s2.0-84901037163&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2010 journal article
Developing an engineered antimicrobial/prophylactic system using electrically activated bactericidal metals
Journal of Materials Science: Materials in Medicine, 21(7), 2103–2114.
Contributors: T. Fuller, R. Wysk*, C. Charumani*, M. Kennett*, W. Sebastiennelli, R. Abrahams *, * , R. Voigt, P. Royer
MeSH headings : Anti-Bacterial Agents / pharmacology; Anti-Infective Agents / pharmacology; Electricity; Electrodes; Gels; Humans; Metals / pharmacology; Silver / pharmacology; Silver Compounds / pharmacology
TL;DR:
A surface treatment based on ionic emission to create an antibiotic environment that can significantly reduce RHD associated infections is proposed.
(via Semantic Scholar)
Sources: ORCID, Crossref
Added: September 6, 2019
2008 journal article
Triz and axiomatic design: A review of case-studies and a proposed synergistic use
Journal of Intelligent Manufacturing, 19(1), 33–47.
author keywords: TRIZ; Axiomatic Design
TL;DR:
Practical applications of TRIZ and AD in solving industrial problems related to manufacturing and designing are reviewed and a new approach of applying these two techniques concurrently to solve a problem to attain efficiency and quality in the problem solving process is proposed.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2019
2007 journal article
Using triz and axiomatic design synergistically: A case study
International Journal of Innovation and Technology Management, 4(2), 155–170.
author keywords: TRIZ; axiomatic design; synergistic problem solving approach
TL;DR:
This paper demonstrates the effectiveness of the synergistic approach through a manufacturing related case-study and considers the importance of validation of engineering models, based on review of design engineering validation literature.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: ORCID
Added: September 6, 2019
2006 conference paper
A multi-stage problem formulation for concept selection for improved product design
Portland International Conference on Management of Engineering and Technology, 6, 2528–2538.
TL;DR:
A new concept selection method is proposed and its application is demonstrated and the utility theory based proposed method formulates the concept selection problem as a multi-stage decision.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2019
2006 conference paper
An investigation on the effectiveness of design ideation using TRIZ
Proceedings of the ASME Design Engineering Technical Conference, 2006. http://www.scopus.com/inward/record.url?eid=2-s2.0-33751337036&partnerID=MN8TOARS
Source: ORCID
Added: September 6, 2019
2006 conference paper
TRIZ and axiomatic design: A review of manufacturing case-studies & their compatibility
Portland International Conference on Management of Engineering and Technology, 6, 2510–2520.
TL;DR:
Practical applications of TRIZ and AD in solving industrial problems related to designing and manufacturing are reviewed to propose that application of these two techniques synergistically to solve a problem will increase the efficiency and quality of the problem solving process.
(via Semantic Scholar)
Source: ORCID
Added: September 6, 2019
Employment
Updated: February 26th, 2023 14:04
2022 - present
North Carolina State University Raleigh, North Carolina, US
Professor and University Faculty Scholar
Industrial & Systems Engineering
2021 - present
North Carolina State University Raleigh, North Carolina, US
Associate Faculty
Mechanical and Aerospace Engineering
2019 - present
North Carolina State University Raleigh, North Carolina, US
Associate Director
Comparative Medicine Institute
2012 - present
North Carolina State University Raleigh, NC, US
Associate Faculty
Biomedical Engineering
2017 - 2022
NC State University Raleigh, NC, US
Associate Professor
Industrial & Systems Engineering
2011 - 2017
North Carolina State University Raleigh, NC, US
Assistant Professor
Industrial & Systems Engineering
Education
Updated: November 9th, 2017 12:13
2007 - 2011
Pennsylvania State University University Park, PA, US
PhD
Industrial & Manufacturing Engineering
2005 - 2007
Pennsylvania State University University Park, PA, US
MS
Industrial & Manufacturing Engineering
2001 - 2005
University of Mumbai Mumbai, Maharashtra, IN
BE
Production Engineering
Funding History
Funding history based on the linked ORCID record. Updated: February 26th, 2023 14:05
grant
September 1, 2022 - August 31, 2025
MRI: Acquisition of a Multi-modal, High-resolution 4D Bioprinting Platform for Multidisciplinary Research and Workforce Training at NC State
Directorate for Engineering
grant
July 1, 2021 - June 30, 2026
Using 3D Nonwovens Fabrication to Engineer Region-Specific Extracellular Matrix Structure and Bioactivity of the Knee Meniscus
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
September 1, 2020 - August 31, 2022
Engineering Multi-scale Structure of the Knee Meniscus using Advanced 3D Nonwovens Fabrication
National Institute of Arthritis and Musculoskeletal and Skin Diseases
grant
September 1, 2017 - August 1, 2021
Collaborative Research: 3D-Biofabrication of hASC-based Biomimetic Osteochondral Tissue and the Role of Extracellular Calcium Receptor
National Science Foundation
grant
June 1, 2017 - May 31, 2023
CAREER: Ultrasound-Assisted Biofabrication Of Biomimetic Soft Tissue Constructs With Aligned Fiber Organization
Directorate for Engineering
grant
June 1, 2017 - May 31, 2022
CAREER: Ultrasound-Assisted Biofabrication Of Biomimetic Soft Tissue Constructs With Aligned Fiber Organization
National Science Foundation
grant
June 1, 2016 - November 30, 2019
Real-time Monitoring of Critical Quality Attributes of Bioprinted Constructs in Manufacturing of Engineered Tissues
Directorate for Engineering
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