Rachel A. Stern

Works (6)

Updated: July 22nd, 2023 21:14

2019 article

Differential ammonia metabolism and toxicity between avian and mammalian species, and effect of ammonia on skeletal muscle: A comparative review

Stern, R. A., & Mozdziak, P. E. (2019, March 12). Journal of Animal Physiology and Animal Nutrition, Vol. 103, pp. 774–785.

By: R. Stern n & P. Mozdziak n 

author keywords: ammonia; avian; cirrhosis; liver; mammalian; muscle
MeSH headings : Ammonia / metabolism; Ammonia / toxicity; Animals; Mammals / metabolism; Muscle, Skeletal / drug effects; Poultry / metabolism; Species Specificity
topics (OpenAlex): Adipose Tissue and Metabolism; Muscle Physiology and Disorders; Mitochondrial Function and Pathology
TL;DR: Understanding the intrinsic physiological mechanisms that allow for ammonia to be utilized for growth has potential to reveal novel approaches to muscle growth in avian species and will provide new targets for preventing muscle degeneration in mammalian species. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 4, 2019

2019 article

Glutamine synthetase in avian muscle contributes to a positive myogenic response to ammonia compared with mammalian muscle

Stern, R. A., & Mozdziak, P. E. (2019, May 8). American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, Vol. 317, pp. R214–R221.

By: R. Stern n & P. Mozdziak n 

author keywords: ammonia; cirrhosis; glutamine; glutamine synthetase; muscle
MeSH headings : Acetates / pharmacology; Animals; Cell Line; Chick Embryo; Glutamate-Ammonia Ligase / metabolism; Glutamine / pharmacology; Humans; Myoblasts / drug effects; Myoblasts / physiology; Rats
topics (OpenAlex): Muscle Physiology and Disorders; Muscle metabolism and nutrition; Adipose Tissue and Metabolism
TL;DR: Data support species differences in skeletal muscle ammonia metabolism and suggest that glutamine synthesis is a mechanism of ammonia utilization in avian muscle. (via Semantic Scholar)
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2. Zero Hunger (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 5, 2019

2018 article

Characterization of TTN Novex Splicing Variants across Species and the Role of RBM20 in Novex-Specific Exon Splicing

Chen, Z., Song, J., Chen, L., Zhu, C., Cai, H., Sun, M., … Guo, W. (2018, February 13). Genes, Vol. 9.

By: Z. Chen *, J. Song *, L. Chen *, C. Zhu *, H. Cai *, M. Sun *, A. Stern n, P. Mozdziak n  ...

Contributors: Z. Chen *, J. Song *, L. Chen *, C. Zhu *, H. Cai *, M. Sun *, A. Stern n, P. Mozdziak n  ...

author keywords: TTN; RBM20; Novex isoforms; cardiomyopathy; alternative splicing
topics (OpenAlex): Cardiomyopathy and Myosin Studies; RNA Research and Splicing; RNA and protein synthesis mechanisms
TL;DR: The expression levels of Novex variants in human hearts with cardiomyopathies suggested that Novexes 2 and 3 could be associated with dilatedCardiomyopathy (DCM) and/or arrhythmogenic right ventricular cardiomeopathy (ARVC). (via Semantic Scholar)
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15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

Ammonia elicits a different myogenic response in avian and murine myotubes

Stern, R. A., Dasarathy, S., & Mozdziak, P. E. (2016, August 29). In Vitro Cellular & Developmental Biology - Animal, Vol. 53, pp. 99–110.

By: R. Stern n, S. Dasarathy * & P. Mozdziak n 

Contributors: R. Stern n, S. Dasarathy * & P. Mozdziak n 

author keywords: Muscle; Myogenesis; Myoblast; Liver; Cirrhosis
MeSH headings : Acetates / pharmacology; Ammonia / pharmacology; Animals; Blotting, Western; Cell Survival / drug effects; Chick Embryo; Gene Expression Regulation / drug effects; Hepatocytes / drug effects; Hepatocytes / metabolism; Mice; Muscle Development / drug effects; Muscle Fibers, Skeletal / cytology; Muscle Fibers, Skeletal / drug effects; Muscle Fibers, Skeletal / physiology; Myostatin / metabolism; Real-Time Polymerase Chain Reaction
topics (OpenAlex): Muscle Physiology and Disorders; Adipose Tissue and Metabolism; Mitochondrial Function and Pathology
TL;DR: Overall, it appears that there is a positive myogenic response to hyperammonemia in avian myotube compared to murine myotubes, which supports a proliferative myogenic environment. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 journal article

Chemoprevention of spontaneous ovarian cancer in the domestic hen

Poultry Science, 96(6), 1901–1909.

By: E. Mocka n, R. Stern n, O. Fletcher n, K. Anderson n , J. Petitte n  & P. Mozdziak n 

author keywords: avian; CP-31398; oviduct; ovarian; cancer
MeSH headings : Adenocarcinoma / prevention & control; Adenocarcinoma / veterinary; Animal Feed / analysis; Animals; Chemoprevention / veterinary; Chickens; Diet / veterinary; Female; Genes, p53 / drug effects; Genital Neoplasms, Female / prevention & control; Genital Neoplasms, Female / veterinary; Ovarian Neoplasms / prevention & control; Ovarian Neoplasms / veterinary; Oviducts / pathology; Oviposition; Pyrimidines / administration & dosage; Pyrimidines / pharmacology
topics (OpenAlex): Ovarian cancer diagnosis and treatment; Endometrial and Cervical Cancer Treatments; Testicular diseases and treatments
TL;DR: CP‐31398 appears to be an effective tool for chemoprevention against ovarian malignancy, but does not appear to affect oviductal malignancies. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2015 article

The effect of hyperammonemia on myostatin and myogenic regulatory factor gene expression in broiler embryos

Stern, R. A., Ashwell, C. M., Dasarathy, S., & Mozdziak, P. E. (2015, January 1). Animal, Vol. 9, pp. 992–999.

By: R. Stern n, C. Ashwell n , S. Dasarathy * & P. Mozdziak n 

Contributors: R. Stern n, C. Ashwell n , S. Dasarathy * & P. Mozdziak n 

author keywords: broiler; hyperammonemia; myogenesis; myogenic regulatory factor; myostatin
MeSH headings : Animals; Chick Embryo; Chickens; Gene Expression Regulation; Hyperammonemia / genetics; Hyperammonemia / metabolism; Hyperammonemia / veterinary; Muscle Development / genetics; Myogenic Regulatory Factors / genetics; Myogenic Regulatory Factors / metabolism; Myogenin / genetics; Myogenin / metabolism; Pectoralis Muscles / metabolism; Poultry Diseases / genetics; Poultry Diseases / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism
topics (OpenAlex): Muscle Physiology and Disorders; Nutrition and Health in Aging; Muscle metabolism and nutrition
TL;DR: Overall, it appears possible to inhibit myostatin expression through hyperammonemia, which is expected to have a positive effect on embryonic myogenesis and postnatal muscle growth. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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