Works (34)
Updated: April 3rd, 2024 17:59
2023 article
Genetic basis of ecologically relevant body shape variation among four genera of cichlid fishes
DeLorenzo, L., Mathews, D., Brandon, A. A., Joglekar, M., Baez, A. C., Moore, E. C., … Powder, K. E. (2023, May 10). MOLECULAR ECOLOGY, Vol. 5.
author keywords: adaptation; Cichlidae; fish diversification; quantitative trait loci
TL;DR:
It is found that convergent body shape phenotypes commonly observed across fish clades are most likely due to distinct genetic and molecular mechanisms.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 5, 2023
2022 journal article
Morphometric and Genetic Description of Trophic Adaptations in Cichlid Fishes
BIOLOGY-BASEL, 11(8).
author keywords: craniofacial; quantitative trait loci; geometric morphometrics
TL;DR:
The genetic and molecular origins of trophic adaptation using Lake Malawi cichlids, which have undergone an exemplary evolutionary radiation, suggest that craniofacial traits are mostly inherited as separate modules, which confers a high potential for the evolution of morphological diversity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: August 8, 2022
2022 journal article
Polygenic sex determination produces modular sex polymorphism in an African cichlid fish
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 119(14).
author keywords: sex chromosomes; Malawi African cichlids; sexual dimorphism; sex determination
MeSH headings : Animals; Cichlids / genetics; Cichlids / physiology; Female; Genetic Fitness; Male; Phenotype; Polymorphism, Genetic; Sex Characteristics; Sex Chromosomes / genetics; Sex Determination Processes
TL;DR:
This work investigates how sex differences emerge in a species with more than one set of sex chromosomes, measuring a variety of morphological, physiological, and behavioral traits and finds that significant creation or loss of variation in diverse traits can occur during transitions among sex chromosome systems.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 10, 2022
2022 article
TCDD alters essential transcriptional regulators of osteogenic differentiation in multipotent mesenchymal stem cells
Watson, A. L. T. D., Carmona Baez, A., Jima, D., Reif, D., Ding, J., Roberts, R., & Kullman, S. W. (2022, November 12). TOXICOLOGICAL SCIENCES, Vol. 11.
author keywords: mesenchymal stem cell; AhR; cell differentiation
MeSH headings : Humans; Osteogenesis / genetics; Polychlorinated Dibenzodioxins / toxicity; Cell Differentiation; Fibroblast Growth Factors / metabolism; Mesenchymal Stem Cells / metabolism; Cells, Cultured; Osteoblasts
TL;DR:
A global transcriptomic landscape during early, intermediate, and apical stages of osteogenic differentiation in vitro in response to TCDD is established to identify novel pathways and transcription factors that may facilitate a better understanding of the osteoblast differentiation process, perturbation by exogenous agents, and potential intervention strategies targeting those specific pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 12, 2022
2021 journal article
Origin of a Giant Sex Chromosome
MOLECULAR BIOLOGY AND EVOLUTION, 38(4), 1554–1569.
author keywords: sex chromosomes; genome evolution; chromosome evolution; supernumerary chromosome; chromosome fusion; genetic conflict
MeSH headings : Animals; Biological Evolution; Cichlids / genetics; DNA Transposable Elements; Female; Genome; Male; Sex Chromosomes; Synteny
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 14, 2021
2020 journal article
Exploratory behaviour is associated with microhabitat and evolutionary radiation in Lake Malawi cichlids
ANIMAL BEHAVIOUR, 160, 121–134.
author keywords: behavioural integration; behavioural modularity; habitat preference; light-dark; novel stimuli; novel tank; open field; scototaxis; stress response; thigmotaxis
TL;DR:
This study investigates behavioural responses to novel environments, or exploratory behaviours, in a previously untested vertebrate system, Lake Malawi cichlid fishes, which comprises hundreds of phenotypically diverse species that have diverged in the past one million years.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 27, 2020
2019 journal article
Chromosome-scale assemblies reveal the structural evolution of African cichlid genomes
GIGASCIENCE, 8(4).
author keywords: genome assembly; African cichlids; comparative genomics; genome rearrangements; chromosome evolution; karyotype; inversion; recombination; transposable elements; genetic maps
MeSH headings : Animals; Chromosome Mapping; Cichlids / genetics; Computational Biology / methods; DNA Transposable Elements; Diploidy; Evolution, Molecular; Genetic Linkage; Genome; Genomics / methods; Karyotype; Molecular Sequence Annotation; Recombination, Genetic; Repetitive Sequences, Nucleic Acid
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 29, 2019
2019 journal article
The genomics of invasion: characterization of red lionfish (Pterois volitans) populations from the native and introduced ranges
BIOLOGICAL INVASIONS, 21(7), 2471–2483.
author keywords: Invasion; Hybridization; Red lionfish; Pterois volitans; Pterois miles; ddRADseq
TL;DR:
Overall, this study of the red lionfish showed the pattern of introduction and suggested a deeper sampling of genomic data from individuals within the native range may reveal hybridization between species as the source of the aggressive invasion.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
14. Life Below Water
(Web of Science; OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 17, 2019
2019 article
The genomics of invasion: characterization of red lionfish (Pterois volitans) populations from the native and introduced ranges (vol 21, pg 2471, 2019)
Reiskind, M. O. B., Reed, E. M. X., Elias, A., Giacomini, J. J., McNear, A. F., Nieuwsma, J., … Williams, B. E. (2019, July). BIOLOGICAL INVASIONS, Vol. 21, pp. 2485–2487.
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2019
2019 journal article
The intestinal environment as an evolutionary adaptation to mouthbrooding in the Astatotilapia burtoni cichlid
FEMS MICROBIOLOGY ECOLOGY, 95(3).
author keywords: cichlid fish; mouthbrooding; social behavior; parental care; starvation; hibernation; estivation
MeSH headings : Adaptation, Physiological / physiology; Animals; Biological Evolution; Cichlids / microbiology; Cichlids / physiology; Consummatory Behavior / physiology; Female; Food; Gastrointestinal Microbiome / genetics; Intestines / cytology; Intestines / microbiology; Intestines / physiology; Starvation
TL;DR:
The gut microbiota of female Astatotilapia burtoni cichlid fish is characterized throughout the obligatory phase of self‐induced starvation during the brooding cycle and is more strongly influenced by physiological changes specific to mouthbrooding including the reduced epithelial turnover and possible production of antimicrobial agents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 20, 2019
2019 journal article
Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus
BMC EVOLUTIONARY BIOLOGY, 19.
author keywords: Aposematism; Coloration; Color variation; Poison frog
MeSH headings : Animals; Anura / genetics; Color; Gene Expression Regulation; Gene Ontology; Melanins / metabolism; Phenotype; Principal Component Analysis; Skin Pigmentation / genetics; Transcriptome / genetics
TL;DR:
This work has taken a transcriptomics-based approach to elucidate the underlying genetic mechanisms affecting color and pattern in a highly polytypic poison frog, and finds differential expression of a suite of genes that control melanogenesis, melanocyte differentiation, and melanocyte proliferation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2019
2018 chapter
Environmental and Genetic Sex Determining Mechanisms in Fishes
In Transitions Between Sexual Systems (pp. 311–344).
TL;DR:
Diversity in sex determination systems of teleost fishes is reviewed and how it has revealed broad mechanistic and evolutionary insights into sexual phenotypes is described.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2017 journal article
An allelic series at pax7a is associated with colour polymorphism diversity in Lake Malawi cichlid fish
MOLECULAR ECOLOGY, 26(10), 2625–2639.
author keywords: allelic series; cichlid fish; colour morphs; pax7; pigmentation
MeSH headings : Africa, Eastern; Alleles; Animals; Cichlids / genetics; Color; Female; Fish Proteins / genetics; Lakes; PAX2 Transcription Factor / genetics; Phenotype; Pigmentation / genetics
TL;DR:
It is confirmed that pax7a-associated blotch morphs result primarily from modulation of melanophore development and survival, and should serve as a case study for understanding the molecular genetic control of pX7a expression and the evolution of sex-associated alleles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Genetic sex determination in Astatotilapia calliptera, a prototype species for the Lake Malawi cichlid radiation
SCIENCE OF NATURE, 104(5-6).
author keywords: Sex chromosome; Genetic sex determination; Cichlid; Fish; Astatotilapia calliptera
MeSH headings : Animal Distribution; Animals; Cichlids / classification; Cichlids / genetics; Cichlids / physiology; Female; Genetic Markers / genetics; Male; Sex Chromosomes / genetics; Sex Determination Processes / genetics; Species Specificity
TL;DR:
This study identifies a male heterogametic XY system segregating at linkage group (LG) 7 in an A. calliptera line that originated from Lake Malawi, at a locus previously shown to act as an XY sex determination system in multiple species of Lake Malawian cichlids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Development of a universal double-digest RAD sequencing approach for a group of nonmodel, ecologically and economically important insect and fish taxa
Molecular Ecology Resources, 16(6), 1303–1314.
author keywords: double-digest RAD sequencing; high-throughput sequencing; reduced representation sequencing; restriction enzyme digests
MeSH headings : Animals; DNA / chemistry; DNA / metabolism; DNA Restriction Enzymes / metabolism; Fishes / genetics; Genomics / methods; Insecta / genetics; Sequence Analysis, DNA / methods
TL;DR:
The results of this study provide empirical evidence of the utility of this method for producing consistent data for diverse nonmodel species and suggest specific considerations for sequencing analysis strategies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref, ORCID
Added: August 6, 2018
2016 journal article
Genital morphology and allometry differ by species and sex in Malawi cichlid fishes
Hydrobiologia, 791(1), 127–143.
author keywords: Genital morphology; Cichlid fishes; Sexual dimorphism; Anogenital distance; Genital papilla
TL;DR:
It is found that the most sexually distinct morphology is in the Lake Malawi rock cichlids and the least sexual dimorphism in the riverine outgroup; additionally, diversity in metrics within genus indicates that these traits are recently evolving.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2016 personal communication
Oil extraction imperils Africa's Great Lakes
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
Polygenic sex determination in the cichlid fish Astatotilapia burtoni
BMC GENOMICS, 17.
author keywords: Sex determination; Polygenic sex determination; Cichlid; Fish; Evolution; Astatotilapia burtoni
MeSH headings : Animals; Cichlids / genetics; Evolution, Molecular; Female; Genetic Association Studies; Genetic Linkage; Inheritance Patterns; Male; Penetrance; Polymorphism, Single Nucleotide; Sex Determination Processes / genetics; Sex Ratio
TL;DR:
Mapping results supporting the presence of multiple, novel sex determination alleles in A. burtoni provide a foundation for future mapping of multiple sex determination genes and their interactions and provide important context for their use in behavioral studies, as well as studies of the evolution of genetic sex determination and sexual conflicts in East African cichlids.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Genetic basis of continuous variation in the levels and modular inheritance of pigmentation in cichlid fishes
MOLECULAR ECOLOGY, 23(21), 5135–5150.
author keywords: cichlids; neural crest cells; phenotypic integration; pigmentation; sexual selection
MeSH headings : Animals; Chromosome Mapping; Cichlids / genetics; Crosses, Genetic; Evolution, Molecular; Female; Fish Proteins / genetics; Genetics, Population; Male; Paired Box Transcription Factors / genetics; Phenotype; Pigmentation / genetics; Quantitative Trait Loci; Selection, Genetic; Sex Determination Processes
TL;DR:
Insight is provided into the genetic basis of complex and continuous patterns of colour variation in cichlid fishes, which offer a vast diversity of pigmentation patterns that have evolved in response to both natural and sexual selection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Structure and decay of a proto-Y region in Tilapia, Oreochromis niloticus
BMC Genomics, 15(1), 975.
MeSH headings : Animals; Cichlids / genetics; Female; Gene Expression Regulation; Genetic Linkage; Genetic Loci; Genetics, Population; Genome; Male; Models, Genetic; Mutation, Missense / genetics; Polymorphism, Single Nucleotide / genetics; Sequence Analysis, DNA; Sex Determination Processes / genetics
TL;DR:
This study demonstrates a block of differentiation on linkage group 1, suggestive of an 8.8 Mb inversion encompassing the sex-determining locus and enrichment of female-biased gene expression inside the proposed inversion suggests incomplete dosage compensation.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2013 article
Polygenic sex determination
Moore, E. C., & Roberts, R. B. (2013, June 17). CURRENT BIOLOGY, Vol. 23, pp. R510–R512.
MeSH headings : Animals; Female; Male; Multifactorial Inheritance; Sex Chromosomes / genetics; Sex Determination Processes / genetics; Sex Determination Processes / physiology; Signal Transduction
TL;DR:
Sex determination is the mechanism by which sexual organisms direct gonad development towards distinct but reproductively compatible outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
A Small Number of Genes Underlie Male Pigmentation Traits in Lake Malawi Cichlid Fishes
Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 318(3), 199–208.
MeSH headings : Animals; Cichlids / genetics; Male; Pigmentation / genetics
TL;DR:
This work quantified the number of pigment cells on the body and fins of two species of the genus Metriaclima and their hybrids and used the Castle-Wright equation to estimate that differences in individual pigmentation traits between these species are controlled by one to four genes each.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2012 journal article
Origins of Shared Genetic Variation in African Cichlids
Molecular Biology and Evolution, 30(4), 906–917.
author keywords: cichlid; evolution; hybridization; ancestral polymorphism; single nucleotide polymorphism; genetic differentiation
MeSH headings : Adaptation, Biological / genetics; Africa; Animals; Bayes Theorem; Cichlids / genetics; Genetic Loci; Genetic Speciation; Genotype; Lakes; Models, Genetic; Phylogeny; Phylogeography; Polymorphism, Single Nucleotide; Principal Component Analysis; Rivers; Selection, Genetic; Sequence Analysis, DNA
TL;DR:
Bayesian and principal component analyses of genetic structure in the data demonstrate that the Lake Malawi endemic flock is not monophyletic and that river species have likely contributed significantly to Malawi genomes, and coalescent simulations support the hypothesis that river cichlids have transported polymorphism between lake assemblages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2011 journal article
Craniofacial divergence and ongoing adaptation via the hedgehog pathway
Proceedings of the National Academy of Sciences, 108(32), 13194–13199.
author keywords: adaptive radiation; development; genetics; quantitative trait loci; trophic morphology
MeSH headings : Adaptation, Physiological / genetics; Alleles; Animals; Biological Evolution; Bone Development; Bone and Bones / anatomy & histology; Chromosome Mapping; Cichlids / anatomy & histology; Cichlids / genetics; Cichlids / growth & development; Face / anatomy & histology; Feeding Behavior; Gene Expression Regulation, Developmental; Genetics, Population; Genotype; Hedgehog Proteins / metabolism; Jaw / anatomy & histology; Jaw / physiology; Larva / physiology; Malawi; Molecular Sequence Data; Patched Receptors; Receptors, Cell Surface / genetics; Receptors, Cell Surface / metabolism; Signal Transduction / genetics; Skull / anatomy & histology; Skull / growth & development; Species Specificity
TL;DR:
Alleles of the hedgehog pathway receptor Patched1 (Ptch1) gene are responsible for adaptive variation in the shape of the lower jaw both within and among genera of Lake Malawi cichlid fish.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2010 journal article
MULTIPLE INTERACTING LOCI CONTROL SEX DETERMINATION IN LAKE MALAWI CICHLID FISH
Evolution, 64(2), 486–501.
author keywords: Sex determination; sexually antagonistic selection; speciation
MeSH headings : Animals; Biological Evolution; Cichlids / genetics; Epistasis, Genetic; Female; Genetic Linkage; Malawi; Male; Sex Determination Processes; Sex Ratio
TL;DR:
The inheritance of sex in 19 fish species from the rapidly evolving flock of cichlids in Lake Malawi, Africa is described and it is found that many of these species have a male heterogametic system on linkage group 7.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2009 journal article
Reduced EGFR causes abnormal valvular differentiation leading to calcific aortic stenosis and left ventricular hypertrophy in C57BL/6J but not 129S1/SvImJ mice
American Journal of Physiology-Heart and Circulatory Physiology, 297(1), H65–H75.
author keywords: epidermal growth factor receptor aortic sclerosis; hypertrophy; aortic stenosis; valvulogenesis
MeSH headings : Alleles; Animals; Aortic Valve Stenosis / diagnostic imaging; Aortic Valve Stenosis / etiology; Aortic Valve Stenosis / pathology; Blood Pressure / physiology; Calcinosis / diagnostic imaging; Calcinosis / etiology; Calcinosis / pathology; Echocardiography; ErbB Receptors / genetics; ErbB Receptors / physiology; Female; Heart Failure / etiology; Heart Failure / pathology; Heart Function Tests; Heart Valves / diagnostic imaging; Heart Valves / growth & development; Hypertrophy, Left Ventricular / diagnostic imaging; Hypertrophy, Left Ventricular / etiology; Hypertrophy, Left Ventricular / pathology; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenotype; Phosphorylation; RNA, Messenger / biosynthesis; RNA, Messenger / genetics; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Survival
TL;DR:
The results show the requirement of EGFR activity for normal valvulogenesis and demonstrate that dominantly acting genetic modifiers curtail pathological changes in congenitally deformed valves.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries, Web Of Science
Added: August 6, 2018
2009 journal article
Sexual Conflict Resolved by Invasion of a Novel Sex Determiner in Lake Malawi Cichlid Fishes
Science, 326(5955), 998–1001.
MeSH headings : Africa, Eastern; Animals; Biological Evolution; Chromosome Mapping; Cichlids / genetics; Cichlids / physiology; Female; Fresh Water; Gene Expression Regulation; Genetic Fitness; Genetic Speciation; Haplotypes; Linkage Disequilibrium; Male; Mating Preference, Animal; Melanophores / cytology; Melanophores / metabolism; Microsatellite Repeats; Molecular Sequence Data; PAX7 Transcription Factor / genetics; Phenotype; Pigmentation / genetics; Polymorphism, Single Nucleotide; Selection, Genetic; Sex Characteristics; Sex Determination Processes; Sexual Behavior, Animal
TL;DR:
The genetic basis for the orange-blotch color pattern, a trait under sexually antagonistic selection in the cichlid fish of Lake Malawi, East Africa, is identified and suggested that the resulting sexual conflict over the OB allele has been resolved by selection for a novel female sex determination locus that has invaded populations with an ancestral male sex determination system.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2007 journal article
Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer
Genome Biology, 8(7), R131.
MeSH headings : Animals; Colon / embryology; Colonic Neoplasms / genetics; Disease Models, Animal; Embryonic Development / genetics; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Humans; Mice; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Wnt Proteins / genetics; beta Catenin / genetics
TL;DR:
Cross-species, developmental, and multi-model gene expression patterning comparisons provide an integrated and versatile framework for definition of transcriptional programs associated with oncogenesis and provide a general method for identifying pattern-specific biomarkers and therapeutic targets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2006 journal article
Wildtype epidermal growth factor receptor (Egfr) is not required for daily locomotor or masking behavior in mice
Journal of Circadian Rhythms, 4(0), 15.
TL;DR:
The results demonstrate that reduced EGFR activity alone is insufficient to perturb locomotor and masking behaviors in mice and suggest that other uncontrolled genetic or environmental parameters confounded previous experiments linking EG FR activity to daily locomotor activity and provide a cautionary tale for genetically uncontrolled studies.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 journal article
Masking in Waved‐2 Mice: EGF Receptor Control of Locomotion Questioned
Chronobiology International, 22(6), 963–974.
author keywords: circadian rhythm; epidermal growth factor; locomotion; masking; subparaventricular zone; waved-2; mutants
MeSH headings : Animals; Circadian Rhythm / genetics; DNA Primers; ErbB Receptors / genetics; Lighting; Mice; Mice, Mutant Strains; Motor Activity / physiology; Polymerase Chain Reaction
TL;DR:
Study of the responses to light over a large range in illumination levels, in a variety of tests, with pulses of light and with ultradian light‐dark cycles in Egfrwa2 mutant mice suggested that normal functioning of epidermal growth factor receptors was required, or even involved, in masking.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2005 chapter
THE MOUSE IN BIOMEDICAL RESEARCH
In The Mouse in Animal Genetics and Breeding Research (pp. 319–340).
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2004 journal article
Modeling the cancer patient with genetically engineered mice
Cancer Cell, 5(2), 115–120.
MeSH headings : Animals; Antibodies, Monoclonal / adverse effects; Antibodies, Monoclonal / pharmacology; Antibodies, Monoclonal, Humanized; Antineoplastic Agents / adverse effects; Antineoplastic Agents / pharmacology; Benzamides; Cardiomyoplasty; Colorectal Neoplasms / drug therapy; Colorectal Neoplasms / physiopathology; Cyclooxygenase 2; Disease Models, Animal; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / metabolism; Gastrointestinal Diseases / chemically induced; Genes, abl / physiology; Genetic Engineering; Humans; Imatinib Mesylate; Isoenzymes / antagonists & inhibitors; Isoenzymes / metabolism; Membrane Proteins; Mice; Mice, Transgenic / genetics; Neoplasms / drug therapy; Neoplasms / physiopathology; Piperazines / adverse effects; Piperazines / pharmacology; Prostaglandin-Endoperoxide Synthases / metabolism; Pyrimidines / adverse effects; Pyrimidines / pharmacology; Receptors, Platelet-Derived Growth Factor; Receptors, Transforming Growth Factor beta / antagonists & inhibitors; Receptors, Transforming Growth Factor beta / metabolism; Skin Abnormalities / chemically induced; Trastuzumab; Vascular Endothelial Growth Factor A / antagonists & inhibitors; Vascular Endothelial Growth Factor A / metabolism
TL;DR:
It is proposed that genetically engineered mouse models can serve as valuable tools to predict targeted therapy toxicity, as well as to identify allelic variants that predispose individuals to side effects.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2002 journal article
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
Proceedings of the National Academy of Sciences, 99(3), 1521–1526.
MeSH headings : Adenoma / pathology; Adenomatous Polyposis Coli / genetics; Animals; Carcinoma / pathology; Colonic Neoplasms / pathology; Crosses, Genetic; Disease Models, Animal; ErbB Receptors / antagonists & inhibitors; ErbB Receptors / deficiency; ErbB Receptors / genetics; ErbB Receptors / physiology; Homozygote; Humans; Intestinal Neoplasms / pathology; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Mutant Strains; Mice, Nude; Signal Transduction; Transplantation, Heterologous; Tumor Cells, Cultured
TL;DR:
It is suggested that normal Egfr activity is required for establishment of intestinal tumors in the ApcMin model between initiation and subsequent expansion of initiated tumors, suggesting that Egfr inhibitors may be useful for advanced colorectal cancer treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
2001 journal article
The 14th annual international mammalian genome society conference: A glimpse into the future of murine functional genomics
Genesis, 29(4), 153–155.
MeSH headings : Animals; Forecasting; Genomics / trends; Mice / genetics
TL;DR:
The atmosphere of the 14 th annual International Mouse Genome Conference (IMGC) can only be described as one of anticipation and preparation for research in the murine postgenomic era, and there was no doubt in any of the attendees’ minds that the availability of the Murine genome sequence will revolutionize mouse-based research.
(via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: January 5, 2020
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