Works (15)
Updated: July 5th, 2023 15:48
2022 journal article
Validation of a combined ultrasound and bioluminescence imaging system with magnetic resonance imaging in orthotopic pancreatic murine tumors
SCIENTIFIC REPORTS, 12(1).
MeSH headings : Animals; Cell Line, Tumor; Disease Progression; Early Detection of Cancer / methods; High-Throughput Screening Assays; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multimodal Imaging; Optical Imaging; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / pathology; Predictive Value of Tests; Reproducibility of Results; Time Factors; Tumor Burden; Ultrasonography
TL;DR:
It is concluded that combining BLI with robotic US offers an efficient screening tool for orthotopic tumor models, and offers complementary advantages of detection sensitivity and quantification accuracy, while mitigating individual technological weaknesses.
(via Semantic Scholar)
open access via www.nature.com (publisher PDF)
Source: Web Of Science
Added: February 7, 2022
2019 article
A preclinical ultrasound platform for widefield 3D imaging of rodent tumors
Czernuszewicz, T., Papadopoulou, V., Rojas, J. D., Rajamahendiran, R., Perdomo, J., Butler, J., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.
TL;DR:
A novel robotic preclinical US imaging system that can accurately and consistently evaluate tumors in rodent models is demonstrated and leverages cost-effective robotic technology, and a new scanning paradigm that allows for easy and reproducible data acquisition to enable wide-field, 3D, multi-parametric ultrasound imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: October 21, 2019
2019 article
Early treatment response detected in a murine clear cell renal cell carcinoma model in response to combination therapy with antiangiogenic and notch inhibition therapy using a non-invasive imaging tool
Rojas, J. D., Papadopoulou, V., Czernuszewicz, T., Rajamahendiran, R., Chytil, A., Chiang, Y.-C., … Dayton, P. (2019, July). CANCER RESEARCH, Vol. 79.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: October 21, 2019
2019 article
Tracking angiogenesis induced microvascular changes in a lymphoma model via a new high throughput non-invasive dual modality imaging platform
Rojas, J. D., Rajamahendiran, R., Czernuszewicz, T. J., Velasco, B., Perdomo, J., Harlacher, M., … Gessner, R. C. (2019, July). CANCER RESEARCH, Vol. 79.
TL;DR:
It is demonstrated that non-invasive measurements of in vivo microvascular remodeling can be precisely mapped to changes in tumor growth with a hybrid modality system, and should prove valuable when using antiangiogenic therapies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: Web Of Science
Added: October 21, 2019
2018 journal article
Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 66(3), 873–880.
author keywords: Microvasculature; angiogenesis; ultrasound; contrast agents; response to therapy; acoustic angiography
MeSH headings : Angiogenesis Inhibitors / pharmacology; Angiography / methods; Animals; Carcinoma, Renal Cell / blood supply; Carcinoma, Renal Cell / diagnostic imaging; Drug Monitoring; Female; Heterografts; Kidney / blood supply; Kidney / diagnostic imaging; Kidney Neoplasms / blood supply; Kidney Neoplasms / diagnostic imaging; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels / diagnostic imaging; Microvessels / drug effects; Microvessels / pathology; Ultrasonography / methods
TL;DR:
Results suggest that future applications utilizing ultrasound imaging to monitor tumor response to therapy may be able to provide earlier insight into tumor behavior from metrics of microvascular density rather than anatomical tumor size measurements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: March 11, 2019
2016 article
Acoustic angiography: A new high frequency contrast ultrasound technique for biomedical imaging
SENSING AND ANALYSIS TECHNOLOGIES FOR BIOMEDICAL AND COGNITIVE APPLICATIONS 2016, Vol. 9871.
author keywords: Ultrasound; contrast agent; microbubble; microvasculature; angiogenesis; broadband; superharmonic; transducer; dual-frequency; acoustic angiography
TL;DR:
Data shows that acoustic angiography can provide important information about the presence of disease based on vascular patterns, and may enable a new paradigm in medical imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
AN IN VIVO VALIDATION OF THE APPLICATION OF ACOUSTIC RADIATION FORCE TO ENHANCE THE DIAGNOSTIC UTILITY OF MOLECULAR IMAGING USING 3-D ULTRASOUND
ULTRASOUND IN MEDICINE AND BIOLOGY, 38(4), 651–660.
author keywords: Microbubble; Molecular imaging; Targeted imaging; Radiation force
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / chemical synthesis; Elasticity Imaging Techniques / methods; Equipment Design; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / pathology; Image Enhancement / methods; Imaging, Three-Dimensional / methods; Microbubbles; Molecular Imaging / methods; Rats, Inbred F344; Sensitivity and Specificity; Transducers
TL;DR:
This is the first noninvasive in vivo validation of ARF-enhanced MI with an unmodified clinical system and demonstrates that a 78% increase in image intensity from targeted microbubbles can be achieved when using ARF relative to the passive targeting studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Mapping Microvasculature with Acoustic Angiography Yields Quantifiable Differences between Healthy and Tumor-bearing Tissue Volumes in a Rodent Model
RADIOLOGY, 264(3), 733–740.
MeSH headings : Animals; Contrast Media; Disease Models, Animal; Female; Fibrosarcoma / diagnostic imaging; Image Processing, Computer-Assisted; Imaging, Three-Dimensional / methods; Microbubbles; Microcirculation; Neovascularization, Pathologic / diagnostic imaging; Prospective Studies; Rats; Rats, Inbred F344; Transducers; Ultrasonography
TL;DR:
Vascular network quantification by using high-spatial-resolution acoustic angiographic images is feasible and suggests that the angiogenic processes associated with tumor development in the models studied result in higher instances of vessel tortuosity near the tumor site.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
3-D MICROVESSEL-MIMICKING ULTRASOUND PHANTOMS PRODUCED WITH A SCANNING MOTION SYSTEM
ULTRASOUND IN MEDICINE AND BIOLOGY, 37(5), 827–833.
author keywords: Phantom; Microbubble; Contrast; 3-D imaging; Vessel; Vessel network; Vessel architecture
MeSH headings : Artifacts; Biomimetic Materials; Contrast Media; Humans; Image Enhancement; Imaging, Three-Dimensional; Microvessels / diagnostic imaging; Motion; Sensitivity and Specificity; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR:
A method to create predefined structures with <10 μm precision using a three-axis motion system is presented, which enables one to precisely simulate very slow blood flow and respiration artifacts, and to measure imaging resolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats
CONTRAST MEDIA & MOLECULAR IMAGING, 6(3), 126–131.
author keywords: anesthesia; carrier gas; microbubble; lifetime; persistence; circulation time
MeSH headings : Air; Anesthetics, Inhalation; Animals; Contrast Media / chemistry; Contrast Media / pharmacokinetics; Diagnostic Imaging / methods; Fluorocarbons; Gases / pharmacology; Lipids; Microbubbles; Rats; Ultrasonography / methods
TL;DR:
Simulations support experimental observations and indicate that enhanced contrast persistence may be explained by reduced ventilation/perfusion mismatch and classical diffusion, in which nitrogen plays a key role by contributing to the volume and diluting other gas species in the microbubble gas core.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 review
Advances in molecular imaging with ultrasound
[Review of ]. Molecular Imaging, 9(3), 117–127.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
High-Resolution, High-Contrast Ultrasound Imaging Using a Prototype Dual-Frequency Transducer: In Vitro and In Vivo Studies
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 57(8), 1772–1781.
MeSH headings : Animals; Blood Flow Velocity; Cattle; Contrast Media / chemistry; Kidney / blood supply; Kidney / diagnostic imaging; Microbubbles; Muscle, Skeletal; Phantoms, Imaging; Rats; Rats, Sprague-Dawley; Renal Circulation / physiology; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR:
This probe demonstrates contrast imaging capability with significant tissue suppression, enabling high-resolution contrast-enhanced images of microvascular blood flow, and can readily produce radiation force on flowing contrast agents, which may be beneficial for targeted imaging or therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Improving sensitivity in ultrasound molecular imaging by tailoring contrast agent size distribution: In vivo studies
Molecular Imaging, 9(2), 87–95.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Quantitative Volumetric Perfusion Mapping of the Microvasculature Using Contrast Ultrasound
INVESTIGATIVE RADIOLOGY, 45(10), 669–674.
author keywords: perfusion; microbubble; 3D; parametric; ultrasound
MeSH headings : Algorithms; Animals; Contrast Media; Feasibility Studies; Hemodynamics; Kidney / blood supply; Kidney / diagnostic imaging; Microvessels / diagnostic imaging; Models, Animal; Perfusion Imaging / instrumentation; Perfusion Imaging / methods; Rats; Rats, Sprague-Dawley; Ultrasonography / instrumentation; Ultrasonography / methods
TL;DR:
Three-dimensional perfusion imaging allows a significant reduction in the error caused by transducer positioning, and significantly improves the reliability of quantitative perfusion time estimates in a rat kidney model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
journal article
Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography
Streeter, J. E., Gessner, R. C., Tsuruta, J., Feingold, S., & Dayton, P. A. Molecular Imaging, 10(6), 460–468.
Source: NC State University Libraries
Added: August 6, 2018
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