Ryan C. Gessner

Works (15)

Updated: July 5th, 2023 15:48

2022 article

Validation of a combined ultrasound and bioluminescence imaging system with magnetic resonance imaging in orthotopic pancreatic murine tumors

Rojas, J. D., Joiner, J. B., Velasco, B., Bautista, K. J. B., Aji, A. M., Moore, C. J., … Czernuszewicz, T. J. (2022, January 7). Scientific Reports.

By: J. Rojas*, J. Joiner *, B. Velasco  n, K. Bautista  n, A. Aji*, C. Moore*, N. Beaumont *, Y. Pylayeva-Gupta * ...

MeSH headings : Animals; Cell Line, Tumor; Disease Progression; Early Detection of Cancer / methods; High-Throughput Screening Assays; Magnetic Resonance Imaging; Mice, Inbred C57BL; Multimodal Imaging; Optical Imaging; Pancreatic Neoplasms / diagnostic imaging; Pancreatic Neoplasms / pathology; Predictive Value of Tests; Reproducibility of Results; Time Factors; Tumor Burden; Ultrasonography
topics (OpenAlex): 3D Printing in Biomedical Research; Cancer Research and Treatments; Cancer Cells and Metastasis
TL;DR: It is concluded that combining BLI with robotic US offers an efficient screening tool for orthotopic tumor models, and offers complementary advantages of detection sensitivity and quantification accuracy, while mitigating individual technological weaknesses. (via Semantic Scholar)
Source: Web Of Science
Added: February 7, 2022

2019 article

Abstract 1935: Tracking angiogenesis induced microvascular changes in a lymphoma model via a new high throughput non-invasive dual modality imaging platform

Rojas, J. D., Rajamahendiran, R., Czernuszewicz, T. J., Velasco, B., Perdomo, J., Harlacher, M., … Gessner, R. C. (2019, July 1). Cancer Research.

By: J. Rojas*, R. Rajamahendiran*, T. Czernuszewicz*, B. Velasco  n, J. Perdomo *, M. Harlacher*, G. O'Connell *, J. Butler * ...

topics (OpenAlex): Photodynamic Therapy Research Studies; bioluminescence and chemiluminescence research
TL;DR: It is demonstrated that non-invasive measurements of in vivo microvascular remodeling can be precisely mapped to changes in tumor growth with a hybrid modality system, and should prove valuable when using antiangiogenic therapies. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 article

Abstract 1955: A preclinical ultrasound platform for widefield 3D imaging of rodent tumors

Czernuszewicz, T., Papadopoulou, V., Rojas, J. D., Rajamahendiran, R., Perdomo, J., Butler, J., … Gessner, R. C. (2019, July 1). Cancer Research.

By: T. Czernuszewicz*, V. Papadopoulou  n, J. Rojas*, R. Rajamahendiran*, J. Perdomo *, J. Butler *, M. Harlacher*, G. O'Connell * ...

topics (OpenAlex): Cancer Research and Treatments; Cancer, Hypoxia, and Metabolism; Cancer Genomics and Diagnostics
TL;DR: A novel robotic preclinical US imaging system that can accurately and consistently evaluate tumors in rodent models is demonstrated and leverages cost-effective robotic technology, and a new scanning paradigm that allows for easy and reproducible data acquisition to enable wide-field, 3D, multi-parametric ultrasound imaging. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2019 article

Abstract 1958: Early treatment response detected in a murine clear cell renal cell carcinoma model in response to combination therapy with antiangiogenic and notch inhibition therapy using a non-invasive imaging tool

Rojas, J. D., Papadopoulou, V., Czernuszewicz, T., Rajamahendiran, R., Chytil, A., Chiang, Y.-C., … Dayton, P. (2019, July 1). Cancer Research.

By: J. Rojas *, V. Papadopoulou  n, T. Czernuszewicz *, R. Rajamahendiran*, A. Chytil*, Y. Chiang*, D. Chong*, V. Bautch * ...

topics (OpenAlex): Renal cell carcinoma treatment; MRI in cancer diagnosis; Renal and Vascular Pathologies
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: October 21, 2019

2018 article

Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma

Rojas, J. D., Papadopoulou, V., Czernuszewicz, T. J., Rajamahendiran, R. M., Chytil, A., Chiang, Y.-C., … Dayton, P. A. (2018, July 27). IEEE Transactions on Biomedical Engineering.

By: J. Rojas n, V. Papadopoulou  n, T. Czernuszewicz*, R. Rajamahendiran*, A. Chytil*, Y. Chiang*, D. Chong*, V. Bautch * ...

author keywords: Microvasculature; angiogenesis; ultrasound; contrast agents; response to therapy; acoustic angiography
MeSH headings : Angiogenesis Inhibitors / pharmacology; Angiography / methods; Animals; Carcinoma, Renal Cell / blood supply; Carcinoma, Renal Cell / diagnostic imaging; Drug Monitoring; Female; Heterografts; Kidney / blood supply; Kidney / diagnostic imaging; Kidney Neoplasms / blood supply; Kidney Neoplasms / diagnostic imaging; Mice; Mice, Inbred NOD; Mice, SCID; Microvessels / diagnostic imaging; Microvessels / drug effects; Microvessels / pathology; Ultrasonography / methods
topics (OpenAlex): MRI in cancer diagnosis; Renal cell carcinoma treatment; Angiogenesis and VEGF in Cancer
TL;DR: Results suggest that future applications utilizing ultrasound imaging to monitor tumor response to therapy may be able to provide earlier insight into tumor behavior from metrics of microvascular density rather than anatomical tumor size measurements. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: March 11, 2019

2016 article

Acoustic angiography: a new high frequency contrast ultrasound technique for biomedical imaging

Shelton, S. E., Lindsey, B. D., Gessner, R., Lee, Y., Aylward, S., Lee, H., … Dayton, P. A. (2016, May 19). Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE, Vol. 9871.

By: S. Shelton n , B. Lindsey  n, R. Gessner n, Y. Lee *, S. Aylward *, H. Lee*, E. Cherin *, F. Foster *, P. Dayton n

author keywords: Ultrasound; contrast agent; microbubble; microvasculature; angiogenesis; broadband; superharmonic; transducer; dual-frequency; acoustic angiography
topics (OpenAlex): Photoacoustic and Ultrasonic Imaging; Ultrasound Imaging and Elastography; Ultrasound and Hyperthermia Applications
TL;DR: Data shows that acoustic angiography can provide important information about the presence of disease based on vascular patterns, and may enable a new paradigm in medical imaging. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

An In Vivo Validation of the Application of Acoustic Radiation Force to Enhance the Diagnostic Utility of Molecular Imaging Using 3-D Ultrasound

Gessner, R. C., Streeter, J. E., Kothadia, R., Feingold, S., & Dayton, P. A. (2012, February 15). Ultrasound in Medicine & Biology.

By: R. Gessner n, J. Streeter n, R. Kothadia n, S. Feingold n & P. Dayton n

author keywords: Microbubble; Molecular imaging; Targeted imaging; Radiation force
MeSH headings : Animals; Contrast Media / administration & dosage; Contrast Media / chemical synthesis; Elasticity Imaging Techniques / methods; Equipment Design; Fibrosarcoma / diagnostic imaging; Fibrosarcoma / pathology; Image Enhancement / methods; Imaging, Three-Dimensional / methods; Microbubbles; Molecular Imaging / methods; Rats, Inbred F344; Sensitivity and Specificity; Transducers
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Ultrasound Imaging and Elastography; Photoacoustic and Ultrasonic Imaging
TL;DR: This is the first noninvasive in vivo validation of ARF-enhanced MI with an unmodified clinical system and demonstrates that a 78% increase in image intensity from targeted microbubbles can be achieved when using ARF relative to the passive targeting studies. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Mapping Microvasculature with Acoustic Angiography Yields Quantifiable Differences between Healthy and Tumor-bearing Tissue Volumes in a Rodent Model

Gessner, R. C., Aylward, S. R., & Dayton, P. A. (2012, July 7). Radiology.

By: R. Gessner n, S. Aylward * & P. Dayton n

MeSH headings : Animals; Contrast Media; Disease Models, Animal; Female; Fibrosarcoma / diagnostic imaging; Image Processing, Computer-Assisted; Imaging, Three-Dimensional / methods; Microbubbles; Microcirculation; Neovascularization, Pathologic / diagnostic imaging; Prospective Studies; Rats; Rats, Inbred F344; Transducers; Ultrasonography
topics (OpenAlex): Photoacoustic and Ultrasonic Imaging; Ultrasound and Hyperthermia Applications; Ultrasound Imaging and Elastography
TL;DR: Vascular network quantification by using high-spatial-resolution acoustic angiographic images is feasible and suggests that the angiogenic processes associated with tumor development in the models studied result in higher instances of vessel tortuosity near the tumor site. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

3-D Microvessel-Mimicking Ultrasound Phantoms Produced With a Scanning Motion System

Gessner, R. C., Kothadia, R., Feingold, S., & Dayton, P. A. (2011, March 25). Ultrasound in Medicine & Biology.

By: R. Gessner n, R. Kothadia n, S. Feingold n & P. Dayton n

author keywords: Phantom; Microbubble; Contrast; 3-D imaging; Vessel; Vessel network; Vessel architecture
MeSH headings : Artifacts; Biomimetic Materials; Contrast Media; Humans; Image Enhancement; Imaging, Three-Dimensional; Microvessels / diagnostic imaging; Motion; Sensitivity and Specificity; Ultrasonography / instrumentation; Ultrasonography / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging; Angiogenesis and VEGF in Cancer
TL;DR: A method to create predefined structures with <10 μm precision using a three-axis motion system is presented, which enables one to precisely simulate very slow blood flow and respiration artifacts, and to measure imaging resolution. (via Semantic Scholar)
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14. Life Below Water (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 article

Effect of anesthesia carrier gas on in vivo circulation times of ultrasound microbubble contrast agents in rats

Mullin, L., Gessner, R., Kwan, J., Kaya, M., Borden, M. A., & Dayton, P. A. (2011, January 19). Contrast Media & Molecular Imaging.

By: L. Mullin n, R. Gessner n, J. Kwan*, M. Kaya  n, M. Borden * & P. Dayton n

author keywords: anesthesia; carrier gas; microbubble; lifetime; persistence; circulation time
MeSH headings : Air; Anesthetics, Inhalation; Animals; Contrast Media / chemistry; Contrast Media / pharmacokinetics; Diagnostic Imaging / methods; Fluorocarbons; Gases / pharmacology; Lipids; Microbubbles; Rats; Ultrasonography / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Ultrasound in Clinical Applications; Photoacoustic and Ultrasonic Imaging
TL;DR: Simulations support experimental observations and indicate that enhanced contrast persistence may be explained by reduced ventilation/perfusion mismatch and classical diffusion, in which nitrogen plays a key role by contributing to the volume and diluting other gas species in the microbubble gas core. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 review

Advances in molecular imaging with ultrasound

[Review of ]. Molecular Imaging, 9(3), 117–127.

By: R. Gessner & P. Dayton

Source: NC State University Libraries
Added: August 6, 2018

2010 article

High-resolution, high-contrast ultrasound imaging using a prototype dual-frequency transducer: In vitro and in vivo studies

Gessner, R., Lukacs, M., Lee, M., Cherin, E., Foster, F. S., & Dayton, P. A. (2010, August 1). IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control.

By: R. Gessner n, M. Lukacs*, M. Lee *, E. Cherin *, F. Foster * & P. Dayton n

MeSH headings : Animals; Blood Flow Velocity; Cattle; Contrast Media / chemistry; Kidney / blood supply; Kidney / diagnostic imaging; Microbubbles; Muscle, Skeletal; Phantoms, Imaging; Rats; Rats, Sprague-Dawley; Renal Circulation / physiology; Transducers; Ultrasonography / instrumentation; Ultrasonography / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging; Ultrasound Imaging and Elastography
TL;DR: This probe demonstrates contrast imaging capability with significant tissue suppression, enabling high-resolution contrast-enhanced images of microvascular blood flow, and can readily produce radiation force on flowing contrast agents, which may be beneficial for targeted imaging or therapy. (via Semantic Scholar)
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16. Peace, Justice and Strong Institutions (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Improving sensitivity in ultrasound molecular imaging by tailoring contrast agent size distribution: In vivo studies

Molecular Imaging, 9(2), 87–95.

By: J. Streeter, R. Gessner, I. Miles & P. Dayton

Source: NC State University Libraries
Added: August 6, 2018

2010 article

Quantitative Volumetric Perfusion Mapping of the Microvasculature Using Contrast Ultrasound

Feingold, S., Gessner, R., Guracar, I. M., & Dayton, P. A. (2010, August 31). Investigative Radiology.

By: S. Feingold n, R. Gessner n, I. Guracar* & P. Dayton n

author keywords: perfusion; microbubble; 3D; parametric; ultrasound
MeSH headings : Algorithms; Animals; Contrast Media; Feasibility Studies; Hemodynamics; Kidney / blood supply; Kidney / diagnostic imaging; Microvessels / diagnostic imaging; Models, Animal; Perfusion Imaging / instrumentation; Perfusion Imaging / methods; Rats; Rats, Sprague-Dawley; Ultrasonography / instrumentation; Ultrasonography / methods
topics (OpenAlex): Ultrasound and Hyperthermia Applications; Photoacoustic and Ultrasonic Imaging
TL;DR: Three-dimensional perfusion imaging allows a significant reduction in the error caused by transducer positioning, and significantly improves the reliability of quantitative perfusion time estimates in a rat kidney model. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

journal article

Assessment of molecular imaging of angiogenesis with three-dimensional ultrasonography

Streeter, J. E., Gessner, R. C., Tsuruta, J., Feingold, S., & Dayton, P. A. Molecular Imaging, 10(6), 460–468.

By: J. Streeter, R. Gessner, J. Tsuruta, S. Feingold & P. Dayton

Source: NC State University Libraries
Added: August 6, 2018

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