Rob Smart

Kotlarz, N., McCord, J., Collier, D., Lea, C. S., Strynar, M., Lindstrom, A. B., … Hoppin, J. A. (2020). Measurement of Novel, Drinking Water-Associated PFAS in Blood from Adults and Children in Wilmington, North Carolina. ENVIRONMENTAL HEALTH PERSPECTIVES, 128(7). https://doi.org/10.1289/EHP6837

Tam, H. W., Hall, J. R., Messenger, Z. J., Jima, D. D., House, J. S., Linder, K., & Smart, R. C. (2019). C/EBP beta suppresses keratinocyte autonomous type 1 IFN response and p53 to increase cell survival and susceptibility to UVB-induced skin cancer. CARCINOGENESIS, 40(9), 1099–1109. https://doi.org/10.1093/carcin/bgz012

Messenger, Z. J., Hall, J. R., Jima, D. D., House, J. S., Tam, H. W., Tokarz, D. A., & Smart, R. C. (2018). C/EBPβ deletion in oncogenic Ras skin tumors is a synthetic lethal event. Cell Death & Disease, 9(11). https://doi.org/10.1038/S41419-018-1103-Y

Hall, J. R., Messenger, Z. J., Tam, H. W., Phillips, S. L., Recio, L., & Smart, R. C. (2015). Long noncoding RNA lincRNA-p21 is the major mediator of UVB-induced and p53-dependent apoptosis in keratinocytes. Cell Death & Disease, 6. https://doi.org/10.1038/cddis.2015.67

Hall, J. R., Bereman, M. S., Nepomuceno, A. I., Thompson, E. A., Muddiman, D. C., & Smart, R. C. (2014). C/EBP alpha regulates CRL4(Cdt2)-mediated degradation of p21 in response to UVB-induced DNA damage to control the G(1)/S checkpoint. Cell Cycle, 13(22), 3602–3610. https://doi.org/10.4161/15384101.2014.962957

Thompson, E. A., Zhu, S., Hall, J. R., House, J. S., Ranjan, R., Burr, J. A., … Smart, R. C. (2011). C/EBP alpha expression Is downregulated in human nonmelanoma skin cancers and inactivation of C/EBP alpha confers susceptibility to UVB-induced skin squamous cell carcinomas. Journal of Investigative Dermatology, 131(6), 1339–1346. https://doi.org/10.1038/jid.2011.31

Deterding, L. J., Williams, J. G., Humble, M. M., Petrovich, R. M., Wei, S. J., Trempus, C. S., … Tomer, K. B. (2011). CD34 antigen: Determination of specific sites of phosphorylation in vitro and in vivo. International Journal of Mass Spectrometry, 301(1-3), 12–21. https://doi.org/10.1016/j.ijms.2010.05.027

Gaddameedhi, S., Selby, C. P., Kaufmann, W. K., Smart, R. C., & Sancar, A. (2011). Control of skin cancer by the circadian rhythm. Proceedings of the National Academy of Sciences, 108(46), 18790–18795. https://doi.org/10.1073/pnas.1115249108

Ming, M., Feng, L., Shea, C. R., Soltani, K., Zhao, B. Z., Han, W. N., … He, Y. Y. (2011). PTEN positively regulates UVB-induced DNA damage repair. Cancer Research, 71(15), 5287–5295. https://doi.org/10.1158/0008-5472.can-10-4614

House, J. S., Zhu, S. Y., Ranjan, R., Linder, K., & Smart, R. C. (2010). C/EBP alpha and C/EBP beta are required for sebocyte differentiation and stratified squamous differentiation in adult mouse skin. PLoS One, 5(3). https://doi.org/10.1371/journal.pone.0009837

Kim, T. H., Chiera, S. L., Linder, K. E., Trempus, C. S., Smart, R. C., & Horowitz, J. M. (2010). Overexpression of transcription factor Sp2 inhibits epidermal differentiation and increases susceptibility to wound- and carcinogen-induced tumorigenesis. Cancer Research, 70(21), 8507–8516. https://doi.org/10.1158/0008-5472.can-10-1213

Lee, S., Shuman, J. D., Guszczynski, T., Sakchaisri, K., Sebastian, T., Copeland, T. D., … Johnson, P. F. (2010). RSK-mediated phosphorylation in the C/EBP beta Leucine zipper regulates DNA binding, dimerization, and growth arrest activity. Molecular and Cellular Biology, 30(11), 2621–2635. https://doi.org/10.1128/mcb.00782-09

Ranjan, R., Thompson, E. A., Yoon, K., & Smart, R. C. (2009). C/EBP alpha expression is partially regulated by C/EBP beta in response to DNA damage and C/EBP alpha-deficient fibroblasts display an impaired G(1) checkpoint. Oncogene, 28(36), 3235–3245. https://doi.org/10.1038/onc.2009.176

Ewing, S. J., Zhu, S., Zhu, F., House, J. S., & Smart, R. C. (2008). C/EBP beta represses p53 to promote cell survival downstream of DNA damage independent of oncogenic Ras and p19(Arf). Cell Death and Differentiation, 15(11), 1734–1744. https://doi.org/10.1038/cdd.2008.105

Yoon, K., Zhu, S., Ewing, S. J., & Smart, R. C. (2007). Decreased survival of C/EBP beta-deficient keratinocytes is due to aberrant regulation of p53 levels and function. Oncogene, 26(3), 360–367. https://doi.org/10.1038/sj.onc.1209797

Loomis, K. D., Zhu, S., Yoon, K., Johnson, P. F., & Smart, R. C. (2007). Genetic ablation of CCAAT/Enhancer binding protein alpha in epidermis reveals its role in suppression of epithelial tumorigenesis. Cancer Research, 67(14), 6768–6776. https://doi.org/10.1158/0008-5472.CAN-07-0139

Sterneck, E., Zhu, S., Ramirez, A., Jorcano, J. L., & Smart, R. C. (2006). Conditional ablation of C/EBP beta demonstrates its keratinocyte-specific requirement for cell survival and mouse skin tumorigenesis. Oncogene, 25(8), 1272–1276. https://doi.org/10.1038/sj.onc.1209144

Omori, E., Matsumoto, K., Sanjo, H., Sato, S., Akira, S., Smart, R. C., & Ninomiya-Tsuji, J. (2006). TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. Journal of Biological Chemistry, 281(28), 19610–19617. https://doi.org/10.1074/jbc.M603384200

Shim, M., Powers, K. L., Ewing, S. J., Zhu, S., & Smart, R. C. (2005). Diminished expression of C/EBP alpha in skin carcinomas is linked to oncogenic Ras and reexpression of C/EBP alpha in carcinoma cells inhibits proliferation. Cancer Research, 65(3), 861–867.

Yoon, K., & Smart, R. C. (2004). C/EBP alpha is a DNA damage-inducible p53-regulated mediator of the G(1) checkpoint in keratinocytes. Molecular and Cellular Biology, 24(24), 10650–10660. https://doi.org/10.1128/MCB.24.24.10650-10660.2004

Shuman, J. D., Sebastian, T., Kaldis, P., Copeland, T. D., Zhu, S. Y., Smart, R. C., & Johnson, P. F. (2004). Cell cycle-dependent phosphorylation of C/EBP beta mediates oncogenic cooperativity between C/EBP beta and H-Ras(V12). Molecular and Cellular Biology, 24(17), 7380–7391. https://doi.org/10.1128/MCB.24.17.7380-7391.2004

Shim, M., & Smart, R. C. (2003). Lithium stabilizes the CCAAT/enhancer-binding protein alpha (C/EBP alpha) through a glycogen synthase kinase 3 (GSK3)- independent pathway involving direct inhibition of proteasomal activity. Journal of Biological Chemistry, 278(22), 19674–19681. https://doi.org/10.1074/jbc.M301356200

Smart, R. C., & Oh, H.-S. (2003). Method of treating alopecia. Washington, DC: U.S. Patent and Trademark Office.

Porter, K. L., Chanda, S., Wang, H. Q., Gaido, K. W., Smart, R. C., & Robinette, C. L. (2002). 17 beta-estradiol is a hormonal regulator of mirex tumor promotion sensitivity in mice. Toxicological Sciences, 69(1), 42–48. https://doi.org/10.1093/toxsci/69.1.42

Zhu, S. Y., Yoon, K., Sterneck, E., Johnson, P. F., & Smart, R. C. (2002). CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling. Proceedings of the National Academy of Sciences of the United States of America, 99(1), 207–212. https://doi.org/10.1073/pnas.012437299

Tiano, H. F., Loftin, C. D., Akunda, J., Lee, C. A., Spalding, J., Sessoms, A., … Langenbach, R. (2002). Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Research, 62(12), 3395–3401.

Smart, R. C., & Oh, H.-S. (2001). Method of treating alopecia. Washington, DC: U.S. Patent and Trademark Office.

Wang, H. Q., Kim, M. P., Tiano, H. F., Langenbach, R., & Smart, R. C. (2001). Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytes. Molecular Pharmacology, 59(4), 860–866. https://doi.org/10.1124/mol.59.4.860

Chanda, S., Robinette, C. L., Couse, J. F., & Smart, R. C. (2000). 17 beta-Estradiol and ICI-182780 regulate the hair follicle cycle in mice through an estrogen receptor-alpha pathway. American Journal of Physiology, 278(2), E202–210. https://doi.org/10.1152/ajpendo.2000.278.2.e202

Owens, D. M., Wei, S. J. C., & Smart, R. C. (1999). A multihit, multistage model of chemical carcinogenesis. Carcinogenesis, 20(9), 1837–1844. https://doi.org/10.1093/carcin/20.9.1837

Zhu, S. Y., Oh, H. S., Shim, M., Sterneck, E., Johnson, P. F., & Smart, R. C. (1999). C/EBP beta modulates the early events of keratinocyte differentiation involving growth arrest and keratin 1 and keratin 10 expression. Molecular and Cellular Biology, 19(10), 7181–7190. https://doi.org/10.1128/mcb.19.10.7181

Matsuura, H., Adachi, H., Smart, R. C., Xu, X. C., Arata, J., & Jetten, A. M. (1999). Correlation between expression of peroxisome proliferator- activated receptor beta and squamous differentiation in epidermal and tracheobronchial epithelial cells. Molecular and Cellular Endocrinology, 147(1-2), 85–92. https://doi.org/10.1016/S0303-7207(98)00214-7

Smart, R. C., Oh, H. S., Chanda, S., & Robinette, C. L. (1999). Effects of 17-beta-estradiol and ICI 182 780 on hair growth in various strains of mice. Journal of Investigative Dermatology, 4(3), 285–289. https://doi.org/10.1038/sj.jidsp.5640231

Smart, R. C., & Oh, H.-S. (1999). Methods of treating alopecia. Washington, DC: U.S. Patent and Trademark Office.

Wang, H. Q., & Smart, R. C. (1999). Overexpression of protein kinase C-[alpha] in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2, and TNF-[alpha] but not tumor promotion. Journal of Cell Science, 112(20), 3497–3506.

Oh, H. S., & Smart, R. C. (1998). Expression of CCAAT/enhancer binding proteins (C/EBP) is associated with squamous differentiation in epidermis and isolated primary keratinocytes and is altered in neoplasms. Journal of Investigative Dermatology, 110(6), 939–945. https://doi.org/10.1046/j.1523-1747.1998.00199.x

Smart, R. C., & Oh, H. S. (1998). On the effect of estrogen receptor agonists and antagonists on the mouse hair follicle cycle. https://doi.org/10.1046/j.1523-1747.1998.00257.x

Kim, T. W., Porter, K. L., Foley, J. F., Maronpot, R. R., & Smart, R. C. (1997). Evidence that mirex promotes a unique population of epidermal cells that cannot be distinguished by their mutant Ha ras genotype. Molecular Carcinogenesis, 20(1), 115–124. https://doi.org/10.1002/(SICI)1098-2744(199709)20:1<115::AID-MC13>3.0.CO;2-4

Meyer, S. A., Kim, T. W., Moser, G. J., Monteiro-Riviere, N. A., & Smart, R. C. (1994). Synergistic interaction between the non-phorbol ester type promoter mirex and 12-O-tetradecanoylphorbol-13-acetate in mouse skin tumor promotion. Carcinogenesis, 15, 47–52. https://doi.org/10.1093/carcin/15.1.47

Meyer, S. A., Moser, G. J., Monteiro-Riviere, N. A., & Smart, R. C. (1993). Minimal role of enhanced cell proliferation in skin tumor promotion by mirex, a new nonphorbol ester-type promoter. Environmental Health Perspectives, 101(Suppl. 5), 265–270. https://doi.org/10.2307/3431879

Smart, R. C., & Crawford, C. L. (1991). Effect of ascorbic acid and its synthetic lipophilic derivative ascorbyl palmitate on phorbol ester-induced skin-tumor promotion in mice. American Journal of Clinical Nutrition, 54, 1266. https://doi.org/10.1093/ajcn/54.6.1266s

Hansen, L. A., Monteiro-Riviere, N. A., & Smart, R. C. (1990). Differential down-regulation of epidermal protein kinase C (PKC) by tetradecanoylphorbol-13-acetate and diacylglycerol: Association with epidermal hyperplasia and tumor promotion. Cancer Research, 50, 5740–5745.

Smart, R. C., Huang, M. T., Monteiro-Riviere, N. A., Wong, C. Q., Mills, K. J., & Conney, A. L. (1988). Comparison of the effect of sn-1,2-didecanoylglycerol and 12-o-tetradecanoylphorbol-13-acetate on cutaneous morphology, inflammation and tumor promotion in CD 1 mice. Carcinogenesis, 9, 2221–2226. https://doi.org/10.1093/carcin/9.12.2221

Huang, M. T., Smart, R. C., Wong, C. Q., & Conney, A. H. (1988). Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-o-tetradecanoylphorbol-13-acetate. Cancer Research, 48(21), 5941–5946.