Russell D Wolfinger

Works (14)

Updated: July 30th, 2023 21:14

2018 article

Chemometric Approaches for Developing Infrared Nanosensors To Image Anthracyclines

Jackson, T. D. B.-O. D., Pinals, R. L., Jeong, S., Thakrar, A., Wolfinger, R. D., & Landry, M. P. (2018, November 27). Biochemistry.

By: T. Jackson *, R. Pinals *, S. Jeong *, A. Thakrar*, R. Wolfinger n & M. Landry *

MeSH headings : Animals; Antibiotics, Antineoplastic / metabolism; Biosensing Techniques / methods; Blood / metabolism; Doxorubicin / metabolism; Fluorescence; Hindlimb / metabolism; Humans; Mice; Molecular Imaging; Nanotechnology / instrumentation; Nanotechnology / methods; Nanotubes, Carbon / chemistry; Small Molecule Libraries / chemistry
topics (OpenAlex): Advanced Chemical Sensor Technologies; bioluminescence and chemiluminescence research; Biosensors and Analytical Detection
Source: Web Of Science
Added: January 28, 2019

2017 article

Identification of dietary patterns associated with obesity in a nationally representative survey of Canadian adults: application of a priori, hybrid, and simplified dietary pattern techniques ,

Jessri, M., Wolfinger, R. D., Lou, W. Y., & L’Abbé, M. R. (2017, February 2). American Journal of Clinical Nutrition.

By: M. Jessri *, R. Wolfinger n, W. Lou * & M. L’Abbé

author keywords: dietary patterns; partial least squares; simplified dietary pattern; Dietary Guidelines for Americans Adherence Index; obesity; chronic diseases; Canadian
MeSH headings : Adult; Canada; Chronic Disease; Cross-Sectional Studies; Diet / adverse effects; Diet Records; Dietary Fats / administration & dosage; Dietary Fiber / administration & dosage; Energy Intake; Feeding Behavior; Female; Health Surveys; Humans; Logistic Models; Male; Mental Recall; Middle Aged; Nutrition Assessment; Nutrition Policy; Obesity / etiology; Obesity, Metabolically Benign / etiology; Odds Ratio; Risk Factors
topics (OpenAlex): Nutritional Studies and Diet; Diet and metabolism studies; Obesity, Physical Activity, Diet
TL;DR: Consuming an energy-dense, high-fat, and LFD dietary pattern and lack of adherence to the recommendations of the 2015 DGAI were associated with a significantly higher risk of obesity with and without accompanying chronic diseases. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

SNP selection and multidimensional scaling to quantify population structure

Miclaus, K., Wolfinger, R., & Czika, W. (2009, February 4). Genetic Epidemiology.

By: K. Miclaus n, R. Wolfinger* & W. Czika*

author keywords: population stratification; substructure-informative SNP selection; Hardy-Weinberg disequilibrium; nonmetric MDS; association studies
MeSH headings : Algorithms; Genetic Markers; Genetics, Population / methods; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Selection, Genetic
topics (OpenAlex): Genetic Associations and Epidemiology; Genetic Mapping and Diversity in Plants and Animals
TL;DR: This work develops methodology for single nucleotide polymorphism (SNP) selection and subsequent population stratification visualization based on deviation from Hardy‐Weinberg equilibrium in conjunction with non‐metric multidimensional scaling (MDS); a distance‐based multivariate technique. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

A gene expression signature of confinement in peripheral blood of red wolves (Canis rufus)

KENNERLY, E. R. I. N., BALLMANN, A. N. N. E., MARTIN, S. T. A. N. T. O. N., WOLFINGER, R. U. S. S., GREGORY, S. I. M. O. N., STOSKOPF, M. I. C. H. A. E. L., & GIBSON, G. R. E. G. (2008, May 2). Molecular Ecology.

By: E. Kennerly n, A. Ballmann  n, S. Martin n, R. Wolfinger*, S. Gregory *, M. Stoskopf n, G. Gibson n

author keywords: conservation genetics; heterologous microarray; Illumina; pro-inflammatory response
MeSH headings : Animals; Biomarkers / blood; Coyotes / genetics; Female; Gene Expression Profiling; Male; Models, Genetic; North Carolina; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Stress, Physiological / genetics; Wolves / genetics
topics (OpenAlex): Molecular Biology Techniques and Applications; Bat Biology and Ecology Studies; Cancer-related molecular mechanisms research
TL;DR: Characterization of differential transcript abundance in an accessible tissue such as peripheral blood identifies biomarkers that could be useful in animal management practices and for evaluating the impact of habitat changes on population health, particularly as attention turns to the effect of climate change on physiology and in turn species distributions. (via Semantic Scholar)
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13. Climate Action (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 review

Global analysis of Arabidopsis gene expression uncovers a complex array of changes impacting pathogen response and cell cycle during geminivirus infection

[Review of ]. Plant Physiology, 148(1), 436–454.

By: J. Ascencio-Ibanez, R. Sozzani, T. Lee, T. Chu, R. Wolfinger, R. Cella, L. Hanley-Bowdoin 

Source: NC State University Libraries
Added: August 6, 2018

2007 article

Comparison of statistical performance of univariate and bivariate mixed models for Affymetrix®probe level data

Hsieh, W.-P., Chu, T.-M., & Wolfinger, R. (2007, March 1). Journal of Statistical Computation and Simulation.

By: W. Hsieh  n, T. Chu* & R. Wolfinger*

author keywords: Affymetrix (R); mixed model; bivariate model; perfect match probes; mismatch probes
topics (OpenAlex): Gene expression and cancer classification; Optimal Experimental Design Methods; Genetic Mapping and Diversity in Plants and Animals
TL;DR: It is shown that the bivariate mixed model offers moderate gains in power over a comparable univariate model that ignores the MM data, and is more prominent when the number of replicates and the array-to-array variability is small. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2007 article

Simultaneous clustering of gene expression data with clinical chemistry and pathological evaluations reveals phenotypic prototypes

Bushel, P. R., Wolfinger, R. D., & Gibson, G. (2007, February 23). BMC Systems Biology.

By: P. Bushel  n, R. Wolfinger* & G. Gibson n

MeSH headings : Acetaminophen / toxicity; Algorithms; Animals; Clinical Chemistry Tests / statistics & numerical data; Cluster Analysis; Data Interpretation, Statistical; Disease Models, Animal; Gene Expression Profiling / statistics & numerical data; Heart Diseases / blood; Heart Diseases / genetics; Heart Diseases / pathology; Humans; Liver / drug effects; Liver / pathology; Necrosis; Phenotype; Rats
topics (OpenAlex): Gene expression and cancer classification; Bioinformatics and Genomic Networks; Molecular Biology Techniques and Applications
TL;DR: Following modk-prototypes clustering of the acetaminophen-exposed samples, informative genes from the cluster prototypes were identified that are descriptive of, and phenotypically anchored to, levels of necrosis of the centrilobular region of the rat liver. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Comparison of Li–Wong and loglinear mixed models for the statistical analysis of oligonucleotide arrays

Chu, T.-M., Weir, B. S., & Wolfinger, R. D. (2004, January 22). Bioinformatics.

By: T. Chu n, B. Weir n & R. Wolfinger n

MeSH headings : Algorithms; Computer Simulation; DNA / chemistry; DNA / genetics; Gene Expression Profiling / methods; Linear Models; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis / methods; Reproducibility of Results; Sensitivity and Specificity
topics (OpenAlex): Gene expression and cancer classification; Genomics and Chromatin Dynamics; Molecular Biology Techniques and Applications
TL;DR: An empirical comparison of the two analysis-of-variance-style mixed models for probe-level, oligonucleotide array data based on a multiplicative parametrization is provided, and finds the models perform quite similarly across most genes, but with some interesting and important distinctions. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2004 article

Variation in transcript abundance during somatic embryogenesis in gymnosperms

Stasolla, C., Bozhkov, P. V., Chu, T.-M., Zyl, L., Egertsdotter, U., Suarez, M. F., … Sederoff, R. R. (2004, October 1). Tree Physiology.

By: C. Stasolla*, P. Bozhkov *, T. Chu*, L. Zyl n, U. Egertsdotter, M. Suarez *, D. Craig n, R. Wolfinger*, S. Arnold*, R. Sederoff n

author keywords: embryo development; gene expression; hybridization; microarray; Picea abies; Pinus taeda
MeSH headings : Cycadopsida / genetics; Cycadopsida / physiology; Gene Expression Regulation, Plant / physiology; Genetic Variation / physiology; Oligonucleotide Array Sequence Analysis; Picea / genetics; Picea / physiology; Seeds / genetics; Seeds / physiology; Transcription, Genetic / physiology; Trees / genetics; Trees / physiology
topics (OpenAlex): Plant tissue culture and regeneration; Plant Molecular Biology Research; Plant Reproductive Biology
TL;DR: Comparison of transcript levels between successive stages of embryogenesis allowed us to identify several genes that showed unique expression responses during normal development, including proteins involved in detoxification processes, methionine synthesis and utilization, and carbohydrate metabolism. (via Semantic Scholar)
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15. Life on Land (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 article

Carbohydrate-induced Differential Gene Expression Patterns in the Hyperthermophilic Bacterium Thermotoga maritima

Chhabra, S. R., Shockley, K. R., Conners, S. B., Scott, K. L., Wolfinger, R. D., & Kelly, R. M. (2003, February 1). Journal of Biological Chemistry, Vol. 278, pp. 7540–7552.

By: S. Chhabra n, K. Shockley*, S. Conners*, K. Scott*, R. Wolfinger* & R. Kelly* 

MeSH headings : Carbohydrate Metabolism; Carbohydrate Sequence; Carbohydrates / chemistry; Carbon / metabolism; DNA, Complementary / metabolism; Down-Regulation; Gene Expression Regulation, Bacterial; Hydrolases / chemistry; Hydrolases / metabolism; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Thermotoga maritima / metabolism; Up-Regulation
topics (OpenAlex): Glycosylation and Glycoproteins Research; Enzyme Production and Characterization; Microbial Metabolites in Food Biotechnology
TL;DR: The transcriptional response of T. maritima to specific carbohydrate growth substrates indicated that sugar backbone- and linkage-specific regulatory networks are operational in this organism during the uptake and utilization of carbohydrate substrates, and suggests that this organism is capable of adapting to a variety of growth environments containing carbohydrate growth substrate. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

Mixed-model reanalysis of primate data suggests tissue and species biases in oligonucleotide-based gene expression profiles

Genetics, 165(2), 747–757.

By: W. Hsieh, T. Chu, R. Wolfinger & G. Gibson

Source: NC State University Libraries
Added: August 6, 2018

2002 article

A systematic statistical linear modeling approach to oligonucleotide array experiments

Chu, T.-M., Weir, B., & Wolfinger, R. (2002, March 1). Mathematical Biosciences.

By: T. Chu n, B. Weir n & R. Wolfinger n

author keywords: microarray; mixed model; split plot; probe
MeSH headings : Cells, Cultured; Humans; Models, Statistical; Oligonucleotide Array Sequence Analysis / methods; Radiation, Ionizing; Transcription, Genetic
topics (OpenAlex): Gene expression and cancer classification; Genomics and Chromatin Dynamics; Molecular Biology Techniques and Applications
TL;DR: The approach employs classical linear mixed models and operates on a gene-by-gene basis and simultaneously considers the data across all chips in an experiment, which can accommodate complex experiments involving many kinds of treatments and test for their effects at the probe level. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2001 article

Assessing Gene Significance from cDNA Microarray Expression Data via Mixed Models

Wolfinger, R. D., Gibson, G., Wolfinger, E. D., Bennett, L., Hamadeh, H., Bushel, P., … Paules, R. S. (2001, November 1). Journal of Computational Biology.

By: R. Wolfinger*, G. Gibson n, E. Wolfinger*, L. Bennett* , H. Hamadeh *, P. Bushel *, C. Afshari*, R. Paules *

Contributors: L. Bennett* 

author keywords: ANOVA; cDNA microarray; gene expression; mixed models; statistical significance
MeSH headings : Computational Biology; Gene Expression Profiling / statistics & numerical data; Genes, Fungal; Humans; Lymphoma, B-Cell / genetics; Models, Genetic; Models, Statistical; Oligonucleotide Array Sequence Analysis / statistics & numerical data; Saccharomyces cerevisiae / genetics
topics (OpenAlex): Gene expression and cancer classification; Bioinformatics and Genomic Networks; Molecular Biology Techniques and Applications
TL;DR: A statistical approach is presented that allows direct control over the percentage of false positives in such a list of differentially expressed genes and, under certain reasonable assumptions, improves on existing methods with respect to the percentages of false negatives. (via Semantic Scholar)
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Sources: Web Of Science, ORCID
Added: August 6, 2018

2001 article

The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster

Jin, W., Riley, R. M., Wolfinger, R. D., White, K. P., Passador-Gurgel, G., & Gibson, G. (2001, November 26). Nature Genetics.

By: W. Jin  n, R. Riley n, R. Wolfinger*, K. White *, G. Passador-Gurgel n & G. Gibson n

MeSH headings : Aging / genetics; Aging / physiology; Animals; Drosophila melanogaster / genetics; Drosophila melanogaster / physiology; Female; Genotype; Male; Sex Factors; Transcription, Genetic
topics (OpenAlex): Gene expression and cancer classification; Genetic Mapping and Diversity in Plants and Animals; Genetic and phenotypic traits in livestock
TL;DR: A statistically rigorous approach to quantifying microarray expression data that allows the relative effects of multiple classes of treatment to be compared and incorporates analytical methods that are common to quantitative genetics is presented. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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