Robert Edward Furlani

Works (4)

Updated: August 2nd, 2023 21:15

2015 journal article

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

TETRAHEDRON LETTERS, 56(23), 3406–3409.

By: M. Richardson*, R. Furlani n, B. Podell *, D. Ackart*, J. Haugen*, R. Melander n, C. Melander n, R. Basaraba *

author keywords: Advanced glycation end-products (AGES); Bis-2-aminoimidazole; Aminoguanidine; Diabetes
TL;DR: The screening of a series of 2-aminoimidazloles for anti-AGE activity is reported, and the identification of a bis-2-aminosidazole lead compound that possesses superior AGE inhibition and breaking activity compared to the known AGE inhibitor aminoguanidine is identified. (via Semantic Scholar)
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Added: August 6, 2018

2015 journal article

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4820–4823.

By: R. Furlani n, M. Richardson*, B. Podell *, D. Ackart*, J. Haugen*, R. Melander n, R. Basaraba *, C. Melander n

author keywords: Advanced glycation end-product (AGE); 2-Aminoimidazole; Akabori; Diabetes
MeSH headings : Glycation End Products, Advanced / antagonists & inhibitors; Glycation End Products, Advanced / metabolism; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Molecular Structure; Structure-Activity Relationship
TL;DR: The use of a rapid, scalable, two-step procedure is reported to access a second generation of 2-AI based anti-AGE compounds from commercially available amino acids that exhibit increased AGE inhibition and breaking activty compared to the first generation compounds. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2015 journal article

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

TETRAHEDRON, 72(25), 3549–3553.

By: C. Brackett n, R. Furlani n, R. Anderson  n, A. Krishnamurthy n, R. Melander n, S. Moskowitz *, R. Ernst *, C. Melander n

author keywords: Antibiotic adjuvant; 2-Aminoimidazole; Colistin; ESKAPE pathogens; Acinetobacter baumannii; Pseudomonas aeruginosa
TL;DR: From these libraries, a new small molecule was identified that lowers the minimum inhibitory concentration of colistin by up to 32-fold greater than the parent compound while also displaying less inherent bacterial effect, thereby minimizing the likelihood of resistance evolution. (via Semantic Scholar)
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Added: August 6, 2018

2012 journal article

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of beta-lactams against multi-drug resistant bacteria

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62, 59–70.

By: R. Furlani n, A. Yeagley  n & C. Melander n

author keywords: Biofilms; MRSA; Suppression of antibiotic resistance; 2-Aminoimidazoles
MeSH headings : Biofilms / drug effects; Dose-Response Relationship, Drug; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Molecular Structure; Structure-Activity Relationship; beta-Lactams / chemistry; beta-Lactams / pharmacology
TL;DR: These 2-AITs were found to inhibit biofilm formation by MRSA with low micromolar IC50 values and acted synergistically with oxacillin against MRSA lowering the minimum inhibitory concentration (MIC) 4-fold. (via Semantic Scholar)
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Added: August 6, 2018

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