Works (35)

Updated: March 2nd, 2024 05:29

2023 journal article

Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance

Physical Review E.

By: C. Ogbunugaforโ€‰*, R. Guerrero nโ€‰, M. Miller-Dickson*, E. Shakhnovichโ€‰* & M. Shouldersโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: January 28, 2024

2023 article

Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance

Ogbunugafor, C. B., Guerrero, R. F., Shakhnovich, E. I., & Shoulders, M. D. (2023, April 9).

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: April 10, 2023

2023 article

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, April 8).

By: R. Guerrero nโ€‰, T. Dorji*, R. Harris*, M. Shouldersโ€‰* & C. Ogbunugaforโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: April 9, 2023

2023 article

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, August 14).

By: R. Guerrero nโ€‰, T. Dorji*, R. Harris*, M. Shouldersโ€‰* & C. Ogbunugaforโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: January 28, 2024

2023 article

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, November 30).

By: R. Guerrero nโ€‰, T. Dorji*, R. Harris*, M. Shouldersโ€‰* & C. Ogbunugaforโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: January 28, 2024

2023 article

Genetic Associations with Dynamic Placental Proteins Identify Causal Biomarkers for Hypertension in Pregnancy

Yan, Q., Blue, N. R., Truong, B., Zhang, Y., Guerrero, R. F., Liu, N., โ€ฆ Haas, D. M. (2023, May 30).

By: Q. Yanโ€‰*, N. Blueโ€‰*, B. Truongโ€‰*, Y. Zhang*, R. Guerrero nโ€‰, N. Liuโ€‰*, M. Honigbergโ€‰*, S. Parry* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: January 28, 2024

2023 article

Polygenic prediction of preeclampsia and gestational hypertension

Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, H. M. T., โ€ฆ Natarajan, P. (2023, May 29). NATURE MEDICINE, Vol. 5.

co-author countries: Estonia ๐Ÿ‡ช๐Ÿ‡ช United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง Norway ๐Ÿ‡ณ๐Ÿ‡ด United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Pregnancy; Female; Child; Humans; Hypertension, Pregnancy-Induced / genetics; Pre-Eclampsia / genetics; Pre-Eclampsia / prevention & control; Eclampsia; Hypertension; Aspirin; Risk Factors
Sources: Web Of Science, ORCID
Added: July 24, 2023

2023 article

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

Yan, Q., Guerrero, R. F., Khan, R. R., Surujnarine, A. A., Wapner, R. J., Hahn, M. W., โ€ฆ Haas, D. M. (2023, June 5).

By: Q. Yanโ€‰*, R. Guerrero nโ€‰, R. Khanโ€‰*, A. Surujnarine*, R. Wapner*, M. Hahn*, A. Rajaโ€‰*, A. SallebAouissiโ€‰* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: January 28, 2024

2023 journal article

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

GENETICS, 225(2).

By: Q. Yanโ€‰*, R. Guerrero nโ€‰, R. Khanโ€‰*, A. Surujnarine*, R. Wapner*, M. Hahn*, A. Rajaโ€‰*, A. Salleb-Aouissiโ€‰* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: GWAS; PheWAS; adverse pregnancy outcomes; nuMoM2b
Sources: Web Of Science, ORCID
Added: February 12, 2024

2022 journal article

Association of Genetic Predisposition and Physical Activity With Risk of Gestational Diabetes in Nulliparous Women

JAMA NETWORK OPEN, 5(8).

By: K. Pagelโ€‰*, H. Chuโ€‰*, R. Ramolaโ€‰*, R. Guerrero nโ€‰, J. Chungโ€‰*, S. Parryโ€‰*, U. Reddy*, R. Silver* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Adult; Cohort Studies; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Diabetes, Gestational / epidemiology; Diabetes, Gestational / genetics; Exercise; Female; Genetic Predisposition to Disease; Humans; Pregnancy
Sources: Web Of Science, ORCID
Added: September 12, 2022

2022 article

Genetic Polymorphisms Associated with Adverse Pregnancy Outcomes in Nulliparas

Guerrero, R. F., Khan, R. R., Wapner, R. J., Hahn, M. W., Raja, A., Salleb-Aouissi, A., โ€ฆ Haas, D. M. (2022, March 1).

By: R. Guerrero nโ€‰, R. Khanโ€‰*, R. Wapner*, M. Hahn*, A. Rajaโ€‰*, A. Salleb-Aouissiโ€‰*, W. Grobman*, H. Simhanโ€‰* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: March 3, 2022

2022 article

Genome-wide meta-analysis identifies novel maternal risk variants and enables polygenic prediction of preeclampsia and gestational hypertension

Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, T. H., โ€ฆ Natarajan, P. (2022, December 1).

By: M. Honigbergโ€‰*, B. Truongโ€‰*, R. Khanโ€‰*, B. Xiaoโ€‰*, L. Bhattaโ€‰*, T. Vyโ€‰*, R. Guerrero nโ€‰, A. Schuermansโ€‰* ...

co-author countries: Belgium ๐Ÿ‡ง๐Ÿ‡ช Canada ๐Ÿ‡จ๐Ÿ‡ฆ Norway ๐Ÿ‡ณ๐Ÿ‡ด United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: December 2, 2022

2022 article

The influence of genetic predisposition and physical activity on risk of Gestational Diabetes Mellitus in the nuMoM2b cohort

Pagel, K. A., Chu, H., Ramola, R., Guerrero, R. F., Chung, J. H., Parry, S., โ€ฆ Radivojac, P. (2022, March 9).

By: K. Pagelโ€‰*, H. Chuโ€‰*, R. Ramolaโ€‰*, R. Guerrero nโ€‰, J. Chungโ€‰*, S. Parryโ€‰*, U. Reddy*, R. Silver* ...

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: ORCID
Added: March 12, 2022

2021 journal article

Inferring the Genetic Basis of Sex Determination from the Genome of a Dioecious Nightshade

MOLECULAR BIOLOGY AND EVOLUTION, 38(7), 2946โ€“2957.

By: M. Wu*, D. Haakโ€‰*, G. Andersonโ€‰*, M. Hahn*, L. Moyleโ€‰* & R. Guerrero nโ€‰

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Ed(s): M. Purugganan

author keywords: sex chromosome; sex evolution; genome assembly; dioecy; Solanum
MeSH headings : Biological Evolution; Gene Expression Regulation, Plant; Genome, Plant; Multigene Family; Pectins / genetics; Sex Determination Processes / genetics; Solanum / genetics
Sources: ORCID, Web Of Science
Added: April 24, 2021

2020 article

The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction

Stamboulian, M., Guerrero, R. F., Hahn, M. W., & Radivojac, P. (2020, July). BIOINFORMATICS, Vol. 36, pp. 219โ€“226.

By: M. Stamboulian*, R. Guerrero nโ€‰, M. Hahn* & P. Radivojacโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Animals; Base Sequence; Evolution, Molecular; Genome; Humans; Mice; Proteins / genetics
Sources: Web Of Science, ORCID
Added: November 9, 2020

2019 journal article

CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases

Human Mutation, 40(9), 1373โ€“1391.

By: L. Kasakโ€‰*, J. Hunterโ€‰*, R. Udaniโ€‰*, C. Bakolitsaโ€‰*, Z. Huโ€‰*, A. Adhikariโ€‰*, G. Babbiโ€‰*, R. Casadioโ€‰* ...

co-author countries: Canada ๐Ÿ‡จ๐Ÿ‡ฆ Germany ๐Ÿ‡ฉ๐Ÿ‡ช Estonia ๐Ÿ‡ช๐Ÿ‡ช United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง India ๐Ÿ‡ฎ๐Ÿ‡ณ Italy ๐Ÿ‡ฎ๐Ÿ‡น United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: CAGI; pediatric rare disease; phenotype prediction; SickKids; variant interpretation; whole-genome sequencing data
MeSH headings : Adolescent; Child; Child, Preschool; Computational Biology / methods; Computer Simulation; Databases, Genetic; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Phenotype; Undiagnosed Diseases / diagnosis; Undiagnosed Diseases / genetics; Whole Genome Sequencing
Source: ORCID
Added: September 15, 2020

2019 journal article

Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance

Genetics, 212(2), 565โ€“575.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: epistasis; proteostasis; antibiotic resistance
MeSH headings : Chlamydia muridarum / drug effects; Chlamydia muridarum / genetics; Chlamydia muridarum / metabolism; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Epistasis, Genetic / drug effects; Escherichia coli / drug effects; Escherichia coli / genetics; Escherichia coli / metabolism; Genetic Association Studies; Genetic Pleiotropy; Listeria / drug effects; Listeria / genetics; Listeria / metabolism; Mutation; Polymorphism, Single Nucleotide; Proteostasis; Tetrahydrofolate Dehydrogenase / genetics
Source: ORCID
Added: September 15, 2020

2018 journal article

Complex selection on a regulator of social cognition: Evidence of balancing selection, regulatory interactions and population differentiation in the prairie vole Avpr1a locus

Molecular Ecology.

By: A. Berrioโ€‰*, R. Guerrero*โ€‰, G. Aglyamova*, M. Okhovatโ€‰*, M. Matzโ€‰* & S. Phelpsโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: adaptation; behaviour/social evolution; gene regulation; population genetics-empirical; sexual fidelity
MeSH headings : Alleles; Animals; Arvicolinae / genetics; Arvicolinae / physiology; Brain / physiology; Cognition / physiology; Genetic Variation; Microsatellite Repeats / genetics; Receptors, Vasopressin / genetics; Sexual Behavior, Animal / physiology; Social Behavior
Source: ORCID
Added: September 15, 2020

2018 journal article

Quantifying the risk of hemiplasy in phylogenetic inference

Proceedings of the National Academy of Sciences, 115(50), 12787โ€“12792.

By: R. Guerrero*โ€‰ & M. Hahn*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: homoplasy; convergence; comparative methods; multispecies coalescent
MeSH headings : Animals; Evolution, Molecular; Genome / genetics; Models, Genetic; Phylogeny; Primates; Probability; Risk Factors
Source: ORCID
Added: September 15, 2020

2017 journal article

Pervasive antagonistic interactions among hybrid incompatibility loci

PLOS Genetics, 13(6), e1006817.

By: R. Guerrero*โ€‰, C. Muirโ€‰*, S. Josway* & L. Moyleโ€‰*

co-author countries: Canada ๐Ÿ‡จ๐Ÿ‡ฆ United States of America ๐Ÿ‡บ๐Ÿ‡ธ

Ed(s): C. Kรถhler

MeSH headings : Chromosome Mapping; Chromosomes, Plant / genetics; Epistasis, Genetic; Fertility / genetics; Genotype; Hybridization, Genetic; Solanum lycopersicum / genetics; Solanum lycopersicum / growth & development; Models, Genetic; Phenotype; Plant Infertility / genetics; Pollen / genetics; Quantitative Trait Loci / genetics; Reproductive Isolation; Seeds / genetics; Species Specificity
Source: ORCID
Added: September 15, 2020

2017 journal article

Speciation as a Sieve for Ancestral Polymorphism

Molecular Ecology, 8.

By: R. Guerrero*โ€‰ & M. Hahn*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: allopatric speciation; balancing selection; differential gene flow; genomic divergence
MeSH headings : Alleles; Gene Flow; Gene Frequency; Genetic Speciation; Genetics, Population; Genomics; Models, Genetic; Polymorphism, Genetic
Source: ORCID
Added: September 15, 2020

2017 journal article

Topological features of a gene co-expression network predict patterns of natural diversity in environmental response

Proceedings of the Royal Society B: Biological Sciences, 284(1856), 20170914.

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: gene by environment interaction; gene regulatory network; Arabidopsis thaliana; abiotic stress; drought; cold
MeSH headings : Adaptation, Physiological / genetics; Arabidopsis / genetics; Arabidopsis / physiology; Cold Temperature; Droughts; Gene Expression Regulation, Plant; Gene Regulatory Networks
Source: ORCID
Added: September 15, 2020

2017 journal article

Transcriptomic analysis links gene expression to unilateral pollen-pistil reproductive barriers.

BMC Plant Biology, 4.

Rafael Guerrero

author keywords: Interspecific reproductive barriers; Interpopulation interactions; Plant mating system; Pollen-pistil transcriptomes; Self-incompatibility; Solanum habrochaites; Unilateral incompatibility; Wild tomato species
MeSH headings : Flowers / genetics; Flowers / physiology; Gene Expression; Gene Expression Profiling; Genes, Plant; Pollen / genetics; Pollen / physiology; Solanum / genetics; Solanum / physiology
Source: ORCID
Added: September 15, 2020

2016 journal article

Genome-wide patterns of regulatory divergence revealed by introgression lines

Evolution, 70(3), 696โ€“706.

By: R. Guerrero*โ€‰, A. Posto*, L. Moyleโ€‰* & M. Hahn*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: cis-Regulation; gene expression; hybrid misregulation; trans-regulation; Solanum lycopersicum; Solanum pennellii
MeSH headings : Gene Expression Regulation, Plant; Hybridization, Genetic; Plant Infertility; Regulatory Elements, Transcriptional; Solanum / classification; Solanum / genetics; Transcriptome
Source: ORCID
Added: September 15, 2020

2016 journal article

Molecular mechanisms of postmating prezygotic reproductive isolation uncovered by transcriptome analysis

Molecular Ecology, 25(11), 2592โ€“2608.

By: J. Peaseโ€‰*, R. Guerrero*โ€‰, N. Shermanโ€‰*, M. Hahn* & L. Moyleโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: hybridization; reproductive isolation; speciation; transcriptomics
MeSH headings : Chromosome Mapping; Crosses, Genetic; Gene Expression Profiling; Genes, Plant; Phenotype; Pollen / genetics; RNA, Plant / genetics; Reproduction / genetics; Reproductive Isolation; Solanum / genetics; Solanum / physiology; Transcriptome
Source: ORCID
Added: September 15, 2020

2014 journal article

LOCAL ADAPTATION AND THE EVOLUTION OF CHROMOSOME FUSIONS

Evolution, 68(10), 2747โ€“2756.

By: R. Guerrero*โ€‰ & M. Kirkpatrickโ€‰*

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Coalescent; population divergence; rearrangements; recombination; Robertsonian translocations; selection
MeSH headings : Adaptation, Physiological / genetics; Alleles; Biological Evolution; Chromosomes / genetics; Genetic Fitness; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
Source: ORCID
Added: September 15, 2020

2014 journal article

Matrix inversions for chromosomal inversions: A method to construct summary statistics in complex coalescent models

Theoretical Population Biology.

Rafael Guerrero

author keywords: Chromosomal inversions; Coalescent models; Local adaptation; Gametic disequilibrium; Approximate Bayesian computation
MeSH headings : Animals; Bayes Theorem; Chromosome Inversion / statistics & numerical data; Linkage Disequilibrium; Models, Genetic; Models, Statistical
Source: ORCID
Added: September 15, 2020

2014 journal article

Signatures of sex-antagonistic selection on recombining sex chromosomes.

Genetics, 6.

Rafael Guerrero

MeSH headings : Animals; Biological Evolution; Female; Genetic Variation; Linkage Disequilibrium; Male; Models, Genetic; Selection, Genetic; Sex Chromosomes / genetics; Silene / genetics
Source: ORCID
Added: September 15, 2020

2014 journal article

Strong reinforcing selection in a Texas wildflower.

Current Biology : CB, 9.

Rafael Guerrero

MeSH headings : Flowers / genetics; Flowers / physiology; Magnoliopsida / genetics; Magnoliopsida / physiology; Models, Genetic; Pigmentation; Reproductive Isolation; Selection, Genetic
Source: ORCID
Added: September 15, 2020

2013 journal article

A sequential coalescent algorithm for chromosomal inversions.

Heredity, 9.

Rafael Guerrero

author keywords: inversions; coalescent; simulation; recombination; linkage disequilibrium; ancestral recombination graph
MeSH headings : Algorithms; Chromosome Inversion; Computer Simulation; Genetics, Population; Linkage Disequilibrium; Models, Genetic; Recombination, Genetic
Source: ORCID
Added: September 15, 2020

2012 journal article

Coalescent patterns for chromosomal inversions in divergent populations.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2.

Rafael Guerrero

author keywords: chromosomal inversions; coalescent models; local adaptation; recombination; genetic variation
MeSH headings : Adaptation, Biological; Alleles; Animals; Chromosome Inversion / genetics; Chromosomes / genetics; Computer Simulation; Evolution, Molecular; Genetic Drift; Genetic Speciation; Genetic Variation; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
Source: ORCID
Added: September 15, 2020

2012 journal article

Cryptic recombination in the ever-young sex chromosomes of Hylid frogs.

Journal of Evolutionary Biology, 10.

Rafael Guerrero

author keywords: approximate Bayesian computation; homomorphic sex chromosomes; Hyla; recombination suppression
MeSH headings : Alleles; Animals; Anura / genetics; Anura / physiology; Biological Evolution; Female; Genes, X-Linked; Genes, Y-Linked; Genetic Linkage; Genetic Markers; Genetic Speciation; Male; Recombination, Genetic / genetics; X Chromosome / genetics; Y Chromosome / genetics
Source: ORCID
Added: September 15, 2020

2012 journal article

REPRODUCTIVE ISOLATION AND LOCAL ADAPTATION QUANTIFIED FOR A CHROMOSOME INVERSION IN A MALARIA MOSQUITO

Evolution, 67(4), 946โ€“958.

By: D. Ayalaโ€‰*, R. Guerrero*โ€‰ & M. Kirkpatrickโ€‰*

co-author countries: France ๐Ÿ‡ซ๐Ÿ‡ท United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: Anopheles; assortative mating; selection; postzygotic; prezygotic; speciation
MeSH headings : Adaptation, Biological / genetics; Animal Migration; Animals; Anopheles / genetics; Cameroon; Chromosome Inversion; Chromosomes, Insect / genetics; Ecosystem; Evolution, Molecular; Genetic Speciation; Heterozygote; Homozygote; Models, Genetic; Population / genetics; Reproductive Isolation; Selection, Genetic
Source: ORCID
Added: September 15, 2020

2011 journal article

About PAR: the distinct evolutionary dynamics of the pseudoautosomal region.

Trends in Genetics : TIG, 9.

Rafael Guerrero

MeSH headings : Algorithms; Animals; Chromosome Mapping; Evolution, Molecular; Genetic Loci; Genetic Variation; Humans; Models, Genetic; Recombination, Genetic; Sex Characteristics; Sex Chromosomes / genetics
Source: ORCID
Added: September 15, 2020

2010 journal article

Patterns of neutral genetic variation on recombining sex chromosomes.

Genetics, 4.

Rafael Guerrero

MeSH headings : Animals; Evolution, Molecular; Female; Genetic Variation / genetics; Male; Models, Genetic; Mutation; Polymorphism, Genetic / genetics; Recombination, Genetic / genetics; Sex Chromosomes / genetics
Source: ORCID
Added: September 15, 2020

Employment

Updated: September 15th, 2020 10:58

2020 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Biological Sciences

Education

Updated: September 15th, 2020 10:58

2007 - 2013

University of Texas at Austin Austin, TX, US
PhD Biology Integrative Biology

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