Works (30)
Updated: July 31st, 2023 21:14
2023 article
Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance
Ogbunugafor, C. B., Guerrero, R. F., Shakhnovich, E. I., & Shoulders, M. D. (2023, April 9).
doi.org (repository)
Source: ORCID
Added: April 10, 2023
2023 article
Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications
Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, April 8).
Source: ORCID
Added: April 9, 2023
2023 article
Polygenic prediction of preeclampsia and gestational hypertension
Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, H. M. T., … Natarajan, P. (2023, May 29). NATURE MEDICINE, Vol. 5.
MeSH headings : Pregnancy; Female; Child; Humans; Hypertension, Pregnancy-Induced / genetics; Pre-Eclampsia / genetics; Pre-Eclampsia / prevention & control; Eclampsia; Hypertension; Aspirin; Risk Factors
Sources: Web Of Science, ORCID
Added: July 24, 2023
2022 journal article
Association of Genetic Predisposition and Physical Activity With Risk of Gestational Diabetes in Nulliparous Women
JAMA NETWORK OPEN, 5(8).
MeSH headings : Adult; Cohort Studies; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Diabetes, Gestational / epidemiology; Diabetes, Gestational / genetics; Exercise; Female; Genetic Predisposition to Disease; Humans; Pregnancy
Sources: Web Of Science, ORCID
Added: September 12, 2022
2022 article
Genetic Polymorphisms Associated with Adverse Pregnancy Outcomes in Nulliparas
Guerrero, R. F., Khan, R. R., Wapner, R. J., Hahn, M. W., Raja, A., Salleb-Aouissi, A., … Haas, D. M. (2022, March 1).
Source: ORCID
Added: March 3, 2022
2022 article
Genome-wide meta-analysis identifies novel maternal risk variants and enables polygenic prediction of preeclampsia and gestational hypertension
Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, T. H., … Natarajan, P. (2022, December 1).
Source: ORCID
Added: December 2, 2022
2022 article
The influence of genetic predisposition and physical activity on risk of Gestational Diabetes Mellitus in the nuMoM2b cohort
Pagel, K. A., Chu, H., Ramola, R., Guerrero, R. F., Chung, J. H., Parry, S., … Radivojac, P. (2022, March 9).
Source: ORCID
Added: March 12, 2022
2021 journal article
Inferring the Genetic Basis of Sex Determination from the Genome of a Dioecious Nightshade
MOLECULAR BIOLOGY AND EVOLUTION, 38(7), 2946–2957.
Ed(s): M. Purugganan
author keywords: sex chromosome; sex evolution; genome assembly; dioecy; Solanum
MeSH headings : Biological Evolution; Gene Expression Regulation, Plant; Genome, Plant; Multigene Family; Pectins / genetics; Sex Determination Processes / genetics; Solanum / genetics
Sources: ORCID, Web Of Science
Added: April 24, 2021
2020 article
Inferring the genetic basis of sex determination from the genome of a dioecious nightshade
Wu, M., Anderson, G. J., Hahn, M. W., Moyle, L. C., & Guerrero, R. F. (2020, July 24). (Vol. 7). Vol. 7.
Source: ORCID
Added: September 15, 2020
2020 article
The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction
Stamboulian, M., Guerrero, R. F., Hahn, M. W., & Radivojac, P. (2020, July). BIOINFORMATICS, Vol. 36, pp. 219–226.
MeSH headings : Animals; Base Sequence; Evolution, Molecular; Genome; Humans; Mice; Proteins / genetics
Sources: Web Of Science, ORCID
Added: November 9, 2020
2019 journal article
CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases
Human Mutation, 40(9), 1373–1391.
author keywords: CAGI; pediatric rare disease; phenotype prediction; SickKids; variant interpretation; whole-genome sequencing data
MeSH headings : Adolescent; Child; Child, Preschool; Computational Biology / methods; Computer Simulation; Databases, Genetic; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Phenotype; Undiagnosed Diseases / diagnosis; Undiagnosed Diseases / genetics; Whole Genome Sequencing
Source: ORCID
Added: September 15, 2020
2019 journal article
Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance
Genetics, 212(2), 565–575.
author keywords: epistasis; proteostasis; antibiotic resistance
MeSH headings : Chlamydia muridarum / drug effects; Chlamydia muridarum / genetics; Chlamydia muridarum / metabolism; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Epistasis, Genetic / drug effects; Escherichia coli / drug effects; Escherichia coli / genetics; Escherichia coli / metabolism; Genetic Association Studies; Genetic Pleiotropy; Listeria / drug effects; Listeria / genetics; Listeria / metabolism; Mutation; Polymorphism, Single Nucleotide; Proteostasis; Tetrahydrofolate Dehydrogenase / genetics
Source: ORCID
Added: September 15, 2020
2018 journal article
Complex selection on a regulator of social cognition: Evidence of balancing selection, regulatory interactions and population differentiation in the prairie vole Avpr1a locus
Molecular Ecology, 27(2), 419–431.
author keywords: adaptation; behaviour/social evolution; gene regulation; population genetics-empirical; sexual fidelity
MeSH headings : Alleles; Animals; Arvicolinae / genetics; Arvicolinae / physiology; Brain / physiology; Cognition / physiology; Genetic Variation; Microsatellite Repeats / genetics; Receptors, Vasopressin / genetics; Sexual Behavior, Animal / physiology; Social Behavior
Source: ORCID
Added: September 15, 2020
2018 journal article
Quantifying the risk of hemiplasy in phylogenetic inference
Proceedings of the National Academy of Sciences, 115(50), 12787–12792.
author keywords: homoplasy; convergence; comparative methods; multispecies coalescent
MeSH headings : Animals; Evolution, Molecular; Genome / genetics; Models, Genetic; Phylogeny; Primates; Probability; Risk Factors
Source: ORCID
Added: September 15, 2020
2017 journal article
Pervasive antagonistic interactions among hybrid incompatibility loci
PLOS Genetics, 13(6), e1006817.
Ed(s): C. Köhler
MeSH headings : Chromosome Mapping; Chromosomes, Plant / genetics; Epistasis, Genetic; Fertility / genetics; Genotype; Hybridization, Genetic; Solanum lycopersicum / genetics; Solanum lycopersicum / growth & development; Models, Genetic; Phenotype; Plant Infertility / genetics; Pollen / genetics; Quantitative Trait Loci / genetics; Reproductive Isolation; Seeds / genetics; Species Specificity
Source: ORCID
Added: September 15, 2020
2017 journal article
Speciation as a Sieve for Ancestral Polymorphism
Molecular Ecology, 8(20), 5362–5368.
author keywords: allopatric speciation; balancing selection; differential gene flow; genomic divergence
MeSH headings : Alleles; Gene Flow; Gene Frequency; Genetic Speciation; Genetics, Population; Genomics; Models, Genetic; Polymorphism, Genetic
Source: ORCID
Added: September 15, 2020
2017 journal article
Topological features of a gene co-expression network predict patterns of natural diversity in environmental response
Proceedings of the Royal Society B: Biological Sciences, 284(1856), 20170914.
author keywords: gene by environment interaction; gene regulatory network; Arabidopsis thaliana; abiotic stress; drought; cold
MeSH headings : Adaptation, Physiological / genetics; Arabidopsis / genetics; Arabidopsis / physiology; Cold Temperature; Droughts; Gene Expression Regulation, Plant; Gene Regulatory Networks
Source: ORCID
Added: September 15, 2020
2017 journal article
Transcriptomic analysis links gene expression to unilateral pollen-pistil reproductive barriers.
BMC Plant Biology, 4.
author keywords: Interspecific reproductive barriers; Interpopulation interactions; Plant mating system; Pollen-pistil transcriptomes; Self-incompatibility; Solanum habrochaites; Unilateral incompatibility; Wild tomato species
MeSH headings : Flowers / genetics; Flowers / physiology; Gene Expression; Gene Expression Profiling; Genes, Plant; Pollen / genetics; Pollen / physiology; Solanum / genetics; Solanum / physiology
Source: ORCID
Added: September 15, 2020
2016 journal article
Genome-wide patterns of regulatory divergence revealed by introgression lines
Evolution, 70(3), 696–706.
author keywords: cis-Regulation; gene expression; hybrid misregulation; trans-regulation; Solanum lycopersicum; Solanum pennellii
MeSH headings : Gene Expression Regulation, Plant; Hybridization, Genetic; Plant Infertility; Regulatory Elements, Transcriptional; Solanum / classification; Solanum / genetics; Transcriptome
Source: ORCID
Added: September 15, 2020
2016 journal article
Molecular mechanisms of postmating prezygotic reproductive isolation uncovered by transcriptome analysis
Molecular Ecology, 25(11), 2592–2608.
author keywords: hybridization; reproductive isolation; speciation; transcriptomics
MeSH headings : Chromosome Mapping; Crosses, Genetic; Gene Expression Profiling; Genes, Plant; Phenotype; Pollen / genetics; RNA, Plant / genetics; Reproduction / genetics; Reproductive Isolation; Solanum / genetics; Solanum / physiology; Transcriptome
Source: ORCID
Added: September 15, 2020
2014 journal article
LOCAL ADAPTATION AND THE EVOLUTION OF CHROMOSOME FUSIONS
Evolution, 68(10), 2747–2756.
author keywords: Coalescent; population divergence; rearrangements; recombination; Robertsonian translocations; selection
MeSH headings : Adaptation, Physiological / genetics; Alleles; Biological Evolution; Chromosomes / genetics; Genetic Fitness; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
Source: ORCID
Added: September 15, 2020
2014 journal article
Matrix inversions for chromosomal inversions: A method to construct summary statistics in complex coalescent models
Theoretical Population Biology.
author keywords: Chromosomal inversions; Coalescent models; Local adaptation; Gametic disequilibrium; Approximate Bayesian computation
MeSH headings : Animals; Bayes Theorem; Chromosome Inversion / statistics & numerical data; Linkage Disequilibrium; Models, Genetic; Models, Statistical
Source: ORCID
Added: September 15, 2020
2014 journal article
Signatures of sex-antagonistic selection on recombining sex chromosomes.
Genetics, 6.
MeSH headings : Animals; Biological Evolution; Female; Genetic Variation; Linkage Disequilibrium; Male; Models, Genetic; Selection, Genetic; Sex Chromosomes / genetics; Silene / genetics
Source: ORCID
Added: September 15, 2020
2014 journal article
Strong reinforcing selection in a Texas wildflower.
Current Biology : CB, 9.
MeSH headings : Flowers / genetics; Flowers / physiology; Magnoliopsida / genetics; Magnoliopsida / physiology; Models, Genetic; Pigmentation; Reproductive Isolation; Selection, Genetic
Source: ORCID
Added: September 15, 2020
2013 journal article
A sequential coalescent algorithm for chromosomal inversions.
Heredity, 9.
author keywords: inversions; coalescent; simulation; recombination; linkage disequilibrium; ancestral recombination graph
MeSH headings : Algorithms; Chromosome Inversion; Computer Simulation; Genetics, Population; Linkage Disequilibrium; Models, Genetic; Recombination, Genetic
Source: ORCID
Added: September 15, 2020
2012 journal article
Coalescent patterns for chromosomal inversions in divergent populations.
Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2.
author keywords: chromosomal inversions; coalescent models; local adaptation; recombination; genetic variation
MeSH headings : Adaptation, Biological; Alleles; Animals; Chromosome Inversion / genetics; Chromosomes / genetics; Computer Simulation; Evolution, Molecular; Genetic Drift; Genetic Speciation; Genetic Variation; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
Source: ORCID
Added: September 15, 2020
2012 journal article
Cryptic recombination in the ever-young sex chromosomes of Hylid frogs.
Journal of Evolutionary Biology, 10.
author keywords: approximate Bayesian computation; homomorphic sex chromosomes; Hyla; recombination suppression
MeSH headings : Alleles; Animals; Anura / genetics; Anura / physiology; Biological Evolution; Female; Genes, X-Linked; Genes, Y-Linked; Genetic Linkage; Genetic Markers; Genetic Speciation; Male; Recombination, Genetic / genetics; X Chromosome / genetics; Y Chromosome / genetics
Source: ORCID
Added: September 15, 2020
2012 journal article
REPRODUCTIVE ISOLATION AND LOCAL ADAPTATION QUANTIFIED FOR A CHROMOSOME INVERSION IN A MALARIA MOSQUITO
Evolution, 67(4), 946–958.
author keywords: Anopheles; assortative mating; selection; postzygotic; prezygotic; speciation
MeSH headings : Adaptation, Biological / genetics; Animal Migration; Animals; Anopheles / genetics; Cameroon; Chromosome Inversion; Chromosomes, Insect / genetics; Ecosystem; Evolution, Molecular; Genetic Speciation; Heterozygote; Homozygote; Models, Genetic; Population / genetics; Reproductive Isolation; Selection, Genetic
Source: ORCID
Added: September 15, 2020
2011 journal article
About PAR: the distinct evolutionary dynamics of the pseudoautosomal region.
Trends in Genetics : TIG, 9.
MeSH headings : Algorithms; Animals; Chromosome Mapping; Evolution, Molecular; Genetic Loci; Genetic Variation; Humans; Models, Genetic; Recombination, Genetic; Sex Characteristics; Sex Chromosomes / genetics
Source: ORCID
Added: September 15, 2020
2010 journal article
Patterns of neutral genetic variation on recombining sex chromosomes.
Genetics, 4.
MeSH headings : Animals; Evolution, Molecular; Female; Genetic Variation / genetics; Male; Models, Genetic; Mutation; Polymorphism, Genetic / genetics; Recombination, Genetic / genetics; Sex Chromosomes / genetics
Source: ORCID
Added: September 15, 2020
Employment
Updated: September 15th, 2020 10:58
2020 - present
North Carolina State University Raleigh, NC, US
Assistant Professor
Biological Sciences
Education
Updated: September 15th, 2020 10:58
2007 - 2013
University of Texas at Austin Austin, TX, US
PhD Biology
Integrative Biology
