Rafael F Guerrero

Works (48)

Updated: March 9th, 2026 07:19

2026 article

A polygenic growth score and risk for large for gestational age birth weight

Aamir, M., Feghali, M., Yee, L., Silver, R. M., Durnwald, C., Steller, J. G., … Scifres, C. M. (2026, February 5). Journal of the Endocrine Society, Vol. 2.

By: M. Aamir n, M. Feghali *, L. Yee*, R. Silver*, C. Durnwald*, J. Steller*, D. Haas*, U. Reddy*, R. Guerrero n , C. Scifres *

topics (OpenAlex): Pregnancy and preeclampsia studies; Gestational Diabetes Research and Management; Birth, Development, and Health
Sources: NC State University Libraries, NC State University Libraries
Added: March 4, 2026

2025 article

A network perspective on the evolution of hybrid incompatibilities

Brud, E., & Guerrero, R. F. (2025, July 15).

By: E. Brud  n & R. Guerrero n 

topics (OpenAlex): Complex Network Analysis Techniques; Bioinformatics and Genomic Networks; Peer-to-Peer Network Technologies
Source: ORCID
Added: July 15, 2025

2025 article

Fetal Polygenic Growth Score and Risk for Large for Gestational Age Birth Weight in Nulliparas: Secondary Analysis of a Prospective Cohort Study

Aamir, M., Feghali, M., Yee, L., Silver, R. M., Durnwald, C., Steller, J. G., … Scifres, C. M. (2025, November 4).

By: M. Aamir  n, M. Feghali *, L. Yee *, R. Silver *, C. Durnwald *, J. Steller *, D. Haas *, R. Guerrero n , C. Scifres *

topics (OpenAlex): Gestational Diabetes Research and Management; Pregnancy and preeclampsia studies; Birth, Development, and Health
Source: ORCID
Added: November 4, 2025

2025 article

Generalisability of Maternal Genetic Risk Score for Birth Weight Across Racial Identity and Ancestry: A Secondary Analysis of a Prospective Cohort Study

Tristani‐Firouzi, B., Pappas, L., Joseph, M., Zeinomar, M., Debbink, M. P., Mims, J., … Blue, N. R. (2025, November 30). BJOG An International Journal of Obstetrics & Gynaecology.

By: B. Tristani‐Firouzi *, L. Pappas *, M. Joseph*, M. Zeinomar*, M. Debbink *, J. Mims*, R. Guerrero n , B. Moore* ...

topics (OpenAlex): Birth, Development, and Health; Race, Genetics, and Society; Folate and B Vitamins Research
Sources: NC State University Libraries, NC State University Libraries
Added: December 2, 2025

2025 article

Genetic associations with placental and pregnancy proteins in maternal serum identify biomarkers for hypertension in pregnancy

Yan, Q., Zhang, Y., Blue, N. R., Truong, B., Guerrero, R. F., Honigberg, M. C., … Haas, D. M. (2025, November 1). American Journal of Obstetrics and Gynecology.

By: Q. Yan *, Y. Zhang*, N. Blue *, B. Truong *, R. Guerrero n , M. Honigberg *, S. Parry *, R. McNeil * ...

topics (OpenAlex): Pregnancy and preeclampsia studies; Genetic Associations and Epidemiology; Renin-Angiotensin System Studies
Sources: NC State University Libraries, NC State University Libraries
Added: November 22, 2025

2025 article

Gonadal Transcriptome Differences Between the Sexes in Wild Caught Southern Flounder ( Paralichthys lethostigma) During a Critical Development Period

Harned, S., Mankiewicz, J. L., Smith, E., Borski, R. J., Guerrero, R. F., Reiskind, M. B., & Godwin, J. (2025, October 22).

By: S. Harned  n, J. Mankiewicz n , E. Smith  n, R. Borski n , R. Guerrero n , M. Reiskind n , J. Godwin n 

topics (OpenAlex): Reproductive biology and impacts on aquatic species; Aquaculture Nutrition and Growth; Fish Biology and Ecology Studies
Source: ORCID
Added: October 22, 2025

2025 article

Gut length evolved under sexual conflict in Lake Malawi cichlids

Baez, A. C., Ciccotto, P. J., Moore, E. C., Peterson, E. N., Lamm, M. S., Roberts, N. B., … Roberts, R. B. (2025, May 26). (J. Gleason, Ed.). Genetics, Vol. 6.

By: A. Baez n , P. Ciccotto*, E. Moore *, E. Peterson n, M. Lamm n, N. Roberts n, K. Coyle n, M. Barker n ...

Ed(s): J. Gleason

author keywords: dietary adaptation; sexual conflict; sex differences; cichlid fish; intestine; trophic level; QTL
topics (OpenAlex): Fish Ecology and Management Studies; Fish Biology and Ecology Studies; Fish biology, ecology, and behavior
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14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 26, 2025

2025 article

Maternal and offspring genome-wide association study of C-reactive protein reveals limited polygenic association with gestational diabetes mellitus

Zhang, Y., Moore, A., Ryckman, K. K., Yan, Q., Guerrero, R. F., Li, M., … Liu, N. (2025, October 2).

By: Y. Zhang *, A. Moore *, K. Ryckman *, Q. Yan *, R. Guerrero n , M. Li *, R. Silver *, L. Yee * ...

topics (OpenAlex): Birth, Development, and Health; Diabetes and associated disorders; Gestational Diabetes Research and Management
Source: ORCID
Added: October 2, 2025

2025 article

Mixed Outcomes in Recombination Rates After Domestication: Revisiting Theory and Data

Bursell, M., Rohilla, M., Ramirez, L., Cheng, Y., Schwarzkopf, E. J., Guerrero, R. F., & Heil, C. S. (2025, April 24). Molecular Ecology, Vol. 4.

By: M. Bursell n, M. Rohilla n, L. Ramirez n, Y. Cheng n, E. Schwarzkopf n, R. Guerrero n , C. Heil n 

author keywords: chicken; domestication; goat; recombination; sheep
topics (OpenAlex): Genetic and phenotypic traits in livestock; Evolution and Genetic Dynamics; Genetic Mapping and Diversity in Plants and Animals
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 24, 2025

2025 article

Network Ontology Transcript Annotation Identifies Genetic Signals Underlying Sex Determination

Orozco, L. R., Weaver, A. E., Klee, D. J., Pauli, C. S., Grassa, C. J., Vergara, D., … Kane, N. C. (2025, May 7).

By: L. Orozco*, A. Weaver*, D. Klee, C. Pauli *, C. Grassa *, D. Vergara *, A. Baptista *, K. White* ...

topics (OpenAlex): Transgenic Plants and Applications; Plant tissue culture and regeneration; Toxin Mechanisms and Immunotoxins
Source: ORCID
Added: May 7, 2025

2024 article

CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

Jain, S., Bakolitsa, C., Brenner, S. E., Radivojac, P., Moult, J., Repo, S., … Zook, J. M. (2024, February 22). Genome Biology, Vol. 25.

By: R. Guerrero  (1 connected NC State author and many others, 436 authors in total )

MeSH headings : Humans; Computational Biology / methods; Mutation, Missense; Phenotype
topics (OpenAlex): Genomics and Rare Diseases; Cancer Genomics and Diagnostics; Biomedical Text Mining and Ontologies
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 article

Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2024, June 4). ELife.

By: R. Guerrero n , T. Dorji*, R. Harris *, M. Shoulders* & C. Ogbunugafor *

topics (OpenAlex): Evolution and Genetic Dynamics; Mathematical and Theoretical Epidemiology and Ecology Models; Evolutionary Game Theory and Cooperation; vaccines and immunoinformatics approaches; Pharmacogenetics and Drug Metabolism
Source: ORCID
Added: June 8, 2024

2024 article

Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas

Khan, R. R., Guerrero, R. F., Wapner, R. J., Hahn, M. W., Raja, A., Salleb-Aouissi, A., … Haas, D. M. (2024, May 7). Scientific Reports, Vol. 14.

By: R. Khan*, R. Guerrero n , R. Wapner *, M. Hahn *, A. Raja *, A. Salleb-Aouissi *, W. Grobman *, H. Simhan * ...

author keywords: Genetic association; Preeclampsia; Preterm birth; Gestational diabetes; Fetal death; Stillbirth; Pregnancy loss; Miscarriage
MeSH headings : Humans; Pregnancy; Female; Polymorphism, Single Nucleotide; Genome-Wide Association Study; Pregnancy Outcome / genetics; Diabetes, Gestational / genetics; Adult; Pre-Eclampsia / genetics; Genetic Predisposition to Disease; Parity / genetics
topics (OpenAlex): Birth, Development, and Health; Pregnancy and preeclampsia studies; Gestational Diabetes Research and Management
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 11, 2024

2023 article

Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance

Ogbunugafor, C. B., Guerrero, R. F., Miller-Dickson, M. D., Shakhnovich, E. I., & Shoulders, M. D. (2023, November 14). Physical Review. E, Vol. 108.

By: C. Ogbunugafor *, R. Guerrero n , M. Miller-Dickson*, E. Shakhnovich * & M. Shoulders*

MeSH headings : Epistasis, Genetic; Escherichia coli / metabolism; Mutation; Phenotype; Tetrahydrofolate Dehydrogenase / genetics; Tetrahydrofolate Dehydrogenase / chemistry; Tetrahydrofolate Dehydrogenase / metabolism; Drug Resistance
topics (OpenAlex): Evolution and Genetic Dynamics; Protein Structure and Dynamics; Bioinformatics and Genomic Networks
TL;DR: It is revealed that protein space is a deceptively complex notion, and that future applications to bioengineering should consider how interactions between amino acid substitutions manifest across different phenotypic subspaces. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 28, 2024

2023 article

Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance

Ogbunugafor, C. B., Guerrero, R. F., Shakhnovich, E. I., & Shoulders, M. D. (2023, April 9).

By: C. Ogbunugafor *, R. Guerrero n , E. Shakhnovich * & M. Shoulders*

topics (OpenAlex): Evolution and Genetic Dynamics; Bacteriophages and microbial interactions; Protein Structure and Dynamics
TL;DR: It is revealed that protein space is a deceptively complex notion, and that the process of protein evolution and engineering should consider how interactions between amino acid substitutions manifest across different phenotypic subspaces. (via Semantic Scholar)
Source: ORCID
Added: April 10, 2023

2023 article

Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, August 14). ELife, Vol. 12.

By: R. Guerrero n , T. Dorji*, R. Harris *, M. Shoulders* & C. Ogbunugafor *

author keywords: druggability; drug resistance; evolutionary biology; evolutionary genetics; E. coli
MeSH headings : beta-Lactamases / genetics; beta-Lactamases / metabolism; Anti-Bacterial Agents / pharmacology; Genetic Fitness; Mutation; beta-Lactams / pharmacology; Alleles; Evolution, Molecular
topics (OpenAlex): Evolution and Genetic Dynamics; vaccines and immunoinformatics approaches; Gene Regulatory Network Analysis; Mathematical and Theoretical Epidemiology and Ecology Models
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 17, 2024

2023 article

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, April 8).

By: R. Guerrero n , T. Dorji*, R. Harris *, M. Shoulders* & C. Ogbunugafor *

topics (OpenAlex): Evolution and Genetic Dynamics; Gene Regulatory Network Analysis; Evolutionary Game Theory and Cooperation
TL;DR: This framework can be applied to other datasets and pathogen-drug systems to understand which pathogen variants in a clinical setting are the most concerning (low variant vulnerability), and which drugs in a panel are most likely to be effective in an infection defined by standing genetic variation in the pathogen drug target (high drug applicability). (via Semantic Scholar)
Source: ORCID
Added: April 9, 2023

2023 article

Genetic Associations with Placental Proteins in Maternal Serum Identify Biomarkers for Hypertension in Pregnancy

Yan, Q., Blue, N. R., Truong, B., Zhang, Y., Guerrero, R. F., Liu, N., … Haas, D. M. (2023, May 30).

By: Q. Yan *, N. Blue *, B. Truong *, Y. Zhang*, R. Guerrero n , N. Liu *, M. Honigberg *, S. Parry * ...

topics (OpenAlex): Pregnancy and preeclampsia studies; Birth, Development, and Health; Gestational Diabetes Research and Management
TL;DR: Significant genetic associations with placental proteins ADAM-12, VEGF, and sFlt-1 are discovered, offering insights into their regulation during pregnancy, and Mendelian randomization analyses demonstrated evidence of causal relationships between placentalprotein links with gestational hypertensive disorders, potentially informing prevention and treatment strategies. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 28, 2024

2023 article

Polygenic prediction of preeclampsia and gestational hypertension

Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, H. M. T., … Natarajan, P. (2023, May 29). Nature Medicine, Vol. 5.

By: M. Honigberg *, B. Truong *, R. Khan*, B. Xiao *, L. Bhatta *, H. Vy *, R. Guerrero n , A. Schuermans * ...

MeSH headings : Pregnancy; Female; Child; Humans; Hypertension, Pregnancy-Induced / genetics; Pre-Eclampsia / genetics; Pre-Eclampsia / prevention & control; Eclampsia; Hypertension; Aspirin; Risk Factors
topics (OpenAlex): Pregnancy and preeclampsia studies; Birth, Development, and Health; Gestational Diabetes Research and Management
TL;DR: The association of maternal DNA sequence variants with preeclampsia is tested in 20,064 cases and 703,117 control individuals and with gestational hypertension in 11,027 cases and 412,788 control individuals across discovery and follow-up cohorts using multi-ancestry meta-analysis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2023 article

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

Yan, Q., Guerrero, R. F., Khan, R. R., Surujnarine, A. A., Wapner, R. J., Hahn, M. W., … Haas, D. M. (2023, June 5).

By: Q. Yan *, R. Guerrero n , R. Khan*, A. Surujnarine*, R. Wapner *, M. Hahn *, A. Raja *, A. SallebAouissi * ...

topics (OpenAlex): Genetic Associations and Epidemiology; Pregnancy and preeclampsia studies; Gestational Diabetes Research and Management
TL;DR: GnuMoM2b is a valuable resource for extraction of pregnancy-related genetic results and shows the potential to facilitate meaningful discoveries. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 28, 2024

2023 article

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

Yan, Q., Guerrero, R. F., Khan, R. R., Surujnarine, A. A., Wapner, R. J., Hahn, M. W., … Haas, D. M. (2023, August 14). Genetics, Vol. 225.

By: Q. Yan *, R. Guerrero n , R. Khan*, A. Surujnarine*, R. Wapner *, M. Hahn *, A. Raja *, A. Salleb-Aouissi * ...

author keywords: GWAS; PheWAS; adverse pregnancy outcomes; nuMoM2b
MeSH headings : Pregnancy; Female; Humans; Genome-Wide Association Study / methods; Phenotype; Risk Factors; Phenomics; Polymorphism, Single Nucleotide
topics (OpenAlex): Genetic Associations and Epidemiology; Pregnancy and preeclampsia studies; Gestational Diabetes Research and Management
TL;DR: GnuMoM2b is a valuable resource for extraction of pregnancy-related genetic results and shows the potential to facilitate meaningful discoveries. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2022 article

Association of Genetic Predisposition and Physical Activity With Risk of Gestational Diabetes in Nulliparous Women

Pagel, K. A., Chu, H., Ramola, R., Guerrero, R. F., Chung, J. H., Parry, S., … Radivojac, P. (2022, August 30). JAMA Network Open, Vol. 8.

By: K. Pagel *, H. Chu *, R. Ramola *, R. Guerrero n , J. Chung *, S. Parry *, U. Reddy *, R. Silver * ...

MeSH headings : Adult; Cohort Studies; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Diabetes, Gestational / epidemiology; Diabetes, Gestational / genetics; Exercise; Female; Genetic Predisposition to Disease; Humans; Pregnancy
topics (OpenAlex): Gestational Diabetes Research and Management; Pregnancy and preeclampsia studies; Birth, Development, and Health
TL;DR: It is suggested that physical activity in early pregnancy is associated with reduced risk of GD and reversal of excess risk in genetically predisposed individuals, and PRS may have utility in identifying women for targeted interventions. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: September 12, 2022

2022 article

Genetic Polymorphisms Associated with Adverse Pregnancy Outcomes in Nulliparas

Guerrero, R. F., Khan, R. R., Wapner, R. J., Hahn, M. W., Raja, A., Salleb-Aouissi, A., … Haas, D. M. (2022, March 1).

By: R. Guerrero n , R. Khan*, R. Wapner *, M. Hahn *, A. Raja *, A. Salleb-Aouissi *, W. Grobman *, H. Simhan * ...

topics (OpenAlex): Pregnancy and preeclampsia studies; Gestational Diabetes Research and Management; Birth, Development, and Health
TL;DR: This study identified genetic associations with gestational diabetes, pregnancy loss, and gestational length and confirms correlations of several previously identified variants with these APOs. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: March 3, 2022

2022 article

Genome-wide meta-analysis identifies novel maternal risk variants and enables polygenic prediction of preeclampsia and gestational hypertension

Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, T. H., … Natarajan, P. (2022, December 1).

By: M. Honigberg *, B. Truong *, R. Khan*, B. Xiao *, L. Bhatta *, T. Vy *, R. Guerrero n , A. Schuermans * ...

topics (OpenAlex): Pregnancy and preeclampsia studies; Birth, Development, and Health; Gestational Diabetes Research and Management
TL;DR: Findings provide mechanistic insights into the hypertensive disorders of pregnancy and advance pregnancy risk stratification as identified loci highlight the role of natriuretic peptide signaling, angiogenesis, renal glomerular function, trophoblast development, and immune dysregulation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 2, 2022

2022 article

The influence of genetic predisposition and physical activity on risk of Gestational Diabetes Mellitus in the nuMoM2b cohort

Pagel, K. A., Chu, H., Ramola, R., Guerrero, R. F., Chung, J. H., Parry, S., … Radivojac, P. (2022, March 9).

By: K. Pagel *, H. Chu *, R. Ramola *, R. Guerrero n , J. Chung *, S. Parry *, U. Reddy *, R. Silver * ...

topics (OpenAlex): Gestational Diabetes Research and Management; Birth, Development, and Health; Pregnancy and preeclampsia studies
TL;DR: In high-risk patient subgroups the addition of PRS resulted in increased risk of GDM diagnosis, suggesting the benefits of targeted PRS ascertainment to encourage early intervention. (via Semantic Scholar)
Source: ORCID
Added: March 12, 2022

2021 article

Inferring the Genetic Basis of Sex Determination from the Genome of a Dioecious Nightshade

Wu, M., Haak, D. C., Anderson, G. J., Hahn, M. W., Moyle, L. C., & Guerrero, R. F. (2021, March 25). (M. Purugganan, Ed.). Molecular Biology and Evolution, Vol. 38, pp. 2946–2957.

By: M. Wu *, D. Haak *, G. Anderson *, M. Hahn *, L. Moyle * & R. Guerrero n 

Ed(s): M. Purugganan

author keywords: sex chromosome; sex evolution; genome assembly; dioecy; Solanum
MeSH headings : Biological Evolution; Gene Expression Regulation, Plant; Genome, Plant; Multigene Family; Pectins / genetics; Sex Determination Processes / genetics; Solanum / genetics
topics (OpenAlex): Plant Reproductive Biology; Genetic diversity and population structure; Plant and animal studies
TL;DR: The first genome sequence of a dioecious Solanum is generated and it is inferred that males in this species are the heterogametic sex and observed patterns of gene-family evolution specific to S. appendiculatum consistently implicate a suite of genes from the regulatory network controlling pectin degradation and modification in the expression of sex. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 24, 2021

2020 article

The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction

Stamboulian, M., Guerrero, R. F., Hahn, M. W., & Radivojac, P. (2020, June 4). Bioinformatics, Vol. 36, pp. 219–226.

By: M. Stamboulian *, R. Guerrero n , M. Hahn * & P. Radivojac *

MeSH headings : Animals; Base Sequence; Evolution, Molecular; Genome; Humans; Mice; Proteins / genetics
topics (OpenAlex): Genomics and Phylogenetic Studies; RNA and protein synthesis mechanisms; Machine Learning in Bioinformatics
TL;DR: The results support the view that the types of homologs used for function transfer are largely irrelevant to the task of function prediction, and aim to maximize the amount of data used for this task, regardless of whether it comes from orthologs or paralogs, is most likely to lead to higher prediction accuracy. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2019 article

CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases

Kasak, L., Hunter, J. M., Udani, R., Bakolitsa, C., Hu, Z., Adhikari, A. N., … Meyn, M. S. (2019, July 19). Human Mutation, Vol. 40, pp. 1373–1391.

By: L. Kasak *, J. Hunter *, R. Udani *, C. Bakolitsa *, Z. Hu *, A. Adhikari *, G. Babbi *, R. Casadio * ...

author keywords: CAGI; pediatric rare disease; phenotype prediction; SickKids; variant interpretation; whole-genome sequencing data
MeSH headings : Adolescent; Child; Child, Preschool; Computational Biology / methods; Computer Simulation; Databases, Genetic; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Phenotype; Undiagnosed Diseases / diagnosis; Undiagnosed Diseases / genetics; Whole Genome Sequencing
topics (OpenAlex): Genomics and Rare Diseases; Genetics and Neurodevelopmental Disorders; Immunodeficiency and Autoimmune Disorders
TL;DR: CAGI4 and CAGI5 participants were provided with WGS data and clinical descriptions of 25 and 24 undiagnosed patients from the SickKids Genome Clinic Project, respectively and Predictors were asked to identify primary and secondary causal variants. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2019 article

Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance

Guerrero, R. F., Scarpino, S. V., Rodrigues, J. V., Hartl, D. L., & Ogbunugafor, C. B. (2019, April 23). Genetics, Vol. 212, pp. 565–575.

By: R. Guerrero* , S. Scarpino *, J. Rodrigues *, D. Hartl * & C. Ogbunugafor *

author keywords: epistasis; proteostasis; antibiotic resistance
MeSH headings : Chlamydia muridarum / drug effects; Chlamydia muridarum / genetics; Chlamydia muridarum / metabolism; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Epistasis, Genetic / drug effects; Escherichia coli / drug effects; Escherichia coli / genetics; Escherichia coli / metabolism; Genetic Association Studies; Genetic Pleiotropy; Listeria / drug effects; Listeria / genetics; Listeria / metabolism; Mutation; Polymorphism, Single Nucleotide; Proteostasis; Tetrahydrofolate Dehydrogenase / genetics
topics (OpenAlex): Evolution and Genetic Dynamics; Wheat and Barley Genetics and Pathology; Metabolomics and Mass Spectrometry Studies
TL;DR: This study disentangle the interactions between different protein quality control genetic backgrounds and two sets of mutations and improves on generic observations that epistasis is widespread by discussing how patterns of epistasis can be partly explained by specific interactions between mutations in an essential enzyme and genes associated with the proteostasis environment. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2018 article

Quantifying the risk of hemiplasy in phylogenetic inference

Guerrero, R. F., & Hahn, M. W. (2018, November 27). Proceedings of the National Academy of Sciences, Vol. 115, pp. 12787–12792.

By: R. Guerrero*  & M. Hahn *

author keywords: homoplasy; convergence; comparative methods; multispecies coalescent
MeSH headings : Animals; Evolution, Molecular; Genome / genetics; Models, Genetic; Phylogeny; Primates; Probability; Risk Factors
topics (OpenAlex): Genetic diversity and population structure; Genomics and Phylogenetic Studies; Evolution and Paleontology Studies
TL;DR: Hemiplasy is as likely—or more likely—than homoplasy for a wide range of conditions, even when levels of discordance are low, and is likely to explain many apparent cases of convergent evolution even when the fraction of discordant regions is low. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2017 article

Complex selection on a regulator of social cognition: Evidence of balancing selection, regulatory interactions and population differentiation in the prairie vole Avpr1a locus

Berrio, A., Guerrero, R. F., Aglyamova, G. V., Okhovat, M., Matz, M. V., & Phelps, S. M. (2017, December 8). Molecular Ecology.

By: A. Berrio *, R. Guerrero* , G. Aglyamova *, M. Okhovat *, M. Matz * & S. Phelps *

author keywords: adaptation; behaviour/social evolution; gene regulation; population genetics-empirical; sexual fidelity
MeSH headings : Alleles; Animals; Arvicolinae / genetics; Arvicolinae / physiology; Brain / physiology; Cognition / physiology; Genetic Variation; Microsatellite Repeats / genetics; Receptors, Vasopressin / genetics; Sexual Behavior, Animal / physiology; Social Behavior
topics (OpenAlex): Neuroendocrine regulation and behavior; Evolutionary Psychology and Human Behavior; Animal Behavior and Reproduction
TL;DR: The data suggest that complex selection on Avpr1a locus favours specific combinations of regulatory polymorphisms, maintains the resulting alleles at population‐specific frequencies, and may contribute to unique patterns of spatial cognition and sexual fidelity among populations. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2017 article

Pervasive antagonistic interactions among hybrid incompatibility loci

Guerrero, R. F., Muir, C. D., Josway, S., & Moyle, L. C. (2017, June 12). (C. Köhler, Ed.). PLoS Genetics, Vol. 13, p. e1006817.

By: R. Guerrero* , C. Muir *, S. Josway* & L. Moyle *

Ed(s): C. Köhler

MeSH headings : Chromosome Mapping; Chromosomes, Plant / genetics; Epistasis, Genetic; Fertility / genetics; Genotype; Hybridization, Genetic; Solanum lycopersicum / genetics; Solanum lycopersicum / growth & development; Models, Genetic; Phenotype; Plant Infertility / genetics; Pollen / genetics; Quantitative Trait Loci / genetics; Reproductive Isolation; Seeds / genetics; Species Specificity
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Chromosomal and Genetic Variations; Plant Molecular Biology Research
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UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2017 article

Speciation as a sieve for ancestral polymorphism

Guerrero, R. F., & Hahn, M. W. (2017, August 9). Molecular Ecology, Vol. 8.

By: R. Guerrero*  & M. Hahn *

author keywords: allopatric speciation; balancing selection; differential gene flow; genomic divergence
MeSH headings : Alleles; Gene Flow; Gene Frequency; Genetic Speciation; Genetics, Population; Genomics; Models, Genetic; Polymorphism, Genetic
topics (OpenAlex): Genetic diversity and population structure; Genomics and Phylogenetic Studies; Evolution and Genetic Dynamics
TL;DR: How ancestral balanced polymorphisms can be “sieved” by the speciation process, which sorts them unequally across descendant lineages is discussed. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2017 article

Topological features of a gene co-expression network predict patterns of natural diversity in environmental response

Marais, D. L. D., Guerrero, R. F., Lasky, J. R., & Scarpino, S. V. (2017, June 14). Proceedings of the Royal Society B Biological Sciences, Vol. 284, p. 20170914.

By: D. Marais *, R. Guerrero* , J. Lasky * & S. Scarpino *

author keywords: gene by environment interaction; gene regulatory network; Arabidopsis thaliana; abiotic stress; drought; cold
MeSH headings : Adaptation, Physiological / genetics; Arabidopsis / genetics; Arabidopsis / physiology; Cold Temperature; Droughts; Gene Expression Regulation, Plant; Gene Regulatory Networks
topics (OpenAlex): Bioinformatics and Genomic Networks; Evolution and Genetic Dynamics; Photosynthetic Processes and Mechanisms
TL;DR: This work investigated the network topology of genes putatively involved in local adaptation to two abiotic stressors—drought and cold—in Arabidopsis thaliana and suggested that the gene-interaction topologies for both cold and drought stress response are non-random. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2017 article

Transcriptomic analysis links gene expression to unilateral pollen-pistil reproductive barriers

Broz, A. K., Guerrero, R. F., Randle, A. M., Baek, Y. S., Hahn, M. W., & Bedinger, P. A. (2017, April 24). BMC Plant Biology, Vol. 4.

By: A. Broz *, R. Guerrero* , A. Randle*, Y. Baek*, M. Hahn * & P. Bedinger *

author keywords: Interspecific reproductive barriers; Interpopulation interactions; Plant mating system; Pollen-pistil transcriptomes; Self-incompatibility; Solanum habrochaites; Unilateral incompatibility; Wild tomato species
MeSH headings : Flowers / genetics; Flowers / physiology; Gene Expression; Gene Expression Profiling; Genes, Plant; Pollen / genetics; Pollen / physiology; Solanum / genetics; Solanum / physiology
topics (OpenAlex): Plant Reproductive Biology; Plant and animal studies; Plant Molecular Biology Research
TL;DR: Gene expression analysis of reproductive tissues allowed us to better understand the molecular basis of interpopulation incompatibility at the level of pollen-pistil interactions and highlighted specific genes, including those in ROS signaling pathways that warrant further study in investigations of UI. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2016 article

Genome-wide patterns of regulatory divergence revealed by introgression lines

Guerrero, R. F., Posto, A. L., Moyle, L. C., & Hahn, M. W. (2016, February 4). Evolution, Vol. 70, pp. 696–706.

By: R. Guerrero* , A. Posto*, L. Moyle * & M. Hahn *

author keywords: cis-Regulation; gene expression; hybrid misregulation; trans-regulation; Solanum lycopersicum; Solanum pennellii
MeSH headings : Gene Expression Regulation, Plant; Hybridization, Genetic; Plant Infertility; Regulatory Elements, Transcriptional; Solanum / classification; Solanum / genetics; Transcriptome
topics (OpenAlex): CRISPR and Genetic Engineering; RNA Research and Splicing; Genetic Mapping and Diversity in Plants and Animals
TL;DR: The mechanisms of divergence in genome-wide patterns of gene expression between the nightshades Solanum pennellii and S. lycopersicum are inferred and it is found that cis- and frans-regulatory changes have had qualitatively similar contributions to divergence in this clade, unlike results from other systems. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2016 article

Molecular mechanisms of postmating prezygotic reproductive isolation uncovered by transcriptome analysis

Pease, J. B., Guerrero, R. F., Sherman, N. A., Hahn, M. W., & Moyle, L. C. (2016, May 2). Molecular Ecology, Vol. 25, pp. 2592–2608.

By: J. Pease *, R. Guerrero* , N. Sherman *, M. Hahn * & L. Moyle *

author keywords: hybridization; reproductive isolation; speciation; transcriptomics
MeSH headings : Chromosome Mapping; Crosses, Genetic; Gene Expression Profiling; Genes, Plant; Phenotype; Pollen / genetics; RNA, Plant / genetics; Reproduction / genetics; Reproductive Isolation; Solanum / genetics; Solanum / physiology; Transcriptome
topics (OpenAlex): Plant Reproductive Biology; Plant and animal studies; Genetic diversity and population structure
TL;DR: This study examines changes in gene expression that accompany the expression of ‘unilateral incompatibility’ (UI), a postmating prezygotic barrier in which fertilization is prevented by gamete rejection in the reproductive tract, but is successful in the reciprocal crossing direction. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2016 article

Pervasive Antagonistic Interactions Among Hybrid Incompatibility Loci

Guerrero, R. F., Muir, C. D., Josway, S., & Moyle, L. C. (2016, December 1). BioRxiv (Cold Spring Harbor Laboratory).

By: R. Guerrero* , C. Muir *, S. Josway* & L. Moyle *

topics (OpenAlex): Genetic diversity and population structure; Genetic Mapping and Diversity in Plants and Animals; Genetic and Environmental Crop Studies
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: August 8, 2024

2014 article

LOCAL ADAPTATION AND THE EVOLUTION OF CHROMOSOME FUSIONS

Guerrero, R. F., & Kirkpatrick, M. (2014, June 25). Evolution, Vol. 68, pp. 2747–2756.

By: R. Guerrero*  & M. Kirkpatrick *

author keywords: Coalescent; population divergence; rearrangements; recombination; Robertsonian translocations; selection
MeSH headings : Adaptation, Physiological / genetics; Alleles; Biological Evolution; Chromosomes / genetics; Genetic Fitness; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
topics (OpenAlex): Chromosomal and Genetic Variations; Evolution and Genetic Dynamics; Genetic Mapping and Diversity in Plants and Animals
TL;DR: Local adaptation could explain the evolution of many of chromosome fusions, which are some of the most common chromosome rearrangements in nature. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2014 article

Matrix inversions for chromosomal inversions: A method to construct summary statistics in complex coalescent models

Rousset, F., Kirkpatrick, M., & Guerrero, R. F. (2014, August 1). Theoretical Population Biology.

By: F. Rousset *, M. Kirkpatrick * & R. Guerrero* 

author keywords: Chromosomal inversions; Coalescent models; Local adaptation; Gametic disequilibrium; Approximate Bayesian computation
MeSH headings : Animals; Bayes Theorem; Chromosome Inversion / statistics & numerical data; Linkage Disequilibrium; Models, Genetic; Models, Statistical
topics (OpenAlex): Genetic Mapping and Diversity in Plants and Animals; Genetic diversity and population structure; Chromosomal and Genetic Variations
TL;DR: A method to construct summary statistics in such complex population structure models by analyzing the disequilibrium between two sites within an inversion and providing an estimator of the distinct recombination rate between these two sites in homokaryotype and heterokaryotypes is defined. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2014 article

Signatures of Sex-Antagonistic Selection on Recombining Sex Chromosomes

Kirkpatrick, M., & Guerrero, R. F. (2014, February 28). Genetics, Vol. 6.

By: M. Kirkpatrick * & R. Guerrero* 

MeSH headings : Animals; Biological Evolution; Female; Genetic Variation; Linkage Disequilibrium; Male; Models, Genetic; Selection, Genetic; Sex Chromosomes / genetics; Silene / genetics
topics (OpenAlex): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Animal Behavior and Reproduction; Plant and animal studies
TL;DR: This work uses coalescent models to characterize the patterns of polymorphism expected within and divergence between recombining X and Y (or Z and W) sex chromosomes and shows how the pattern of divergence is altered when the SA polymorphism or the sex-determining region was recently established. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2014 article

Strong Reinforcing Selection in a Texas Wildflower

Hopkins, R., Guerrero, R. F., Rausher, M. D., & Kirkpatrick, M. (2014, August 21). Current Biology, Vol. 9.

By: R. Hopkins *, R. Guerrero* , M. Rausher * & M. Kirkpatrick *

MeSH headings : Flowers / genetics; Flowers / physiology; Magnoliopsida / genetics; Magnoliopsida / physiology; Models, Genetic; Pigmentation; Reproductive Isolation; Selection, Genetic
topics (OpenAlex): Turfgrass Adaptation and Management; Botany, Ecology, and Taxonomy Studies; Seedling growth and survival studies
TL;DR: This work quantifies the strength of reinforcing selection in the Texas wildflower Phlox drummondii using a strategy that weds a population genetic model with field data and finds that selection on flower color genes generated by reinforcement is exceptionally strong. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2013 article

A sequential coalescent algorithm for chromosomal inversions

Peischl, S., Koch, E., Guerrero, R. F., & Kirkpatrick, M. (2013, May 1). Heredity, Vol. 9.

By: S. Peischl *, E. Koch *, R. Guerrero*  & M. Kirkpatrick *

author keywords: inversions; coalescent; simulation; recombination; linkage disequilibrium; ancestral recombination graph
MeSH headings : Algorithms; Chromosome Inversion; Computer Simulation; Genetics, Population; Linkage Disequilibrium; Models, Genetic; Recombination, Genetic
topics (OpenAlex): Chromosomal and Genetic Variations; Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Genetic diversity and population structure
TL;DR: The SMC algorithm is fast, memory-efficient and accurate, making it feasible to simulate large inversions in large populations for the first time, and enables studies of patterns of genetic variation and tests of hypotheses that were previously intractable. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2012 article

Cryptic recombination in the ever‐young sex chromosomes of Hylid frogs

Guerrero, R. F., Kirkpatrick, M., & Perrin, N. (2012, August 17). Journal of Evolutionary Biology, Vol. 10.

By: R. Guerrero* , M. Kirkpatrick * & N. Perrin *

author keywords: approximate Bayesian computation; homomorphic sex chromosomes; Hyla; recombination suppression
MeSH headings : Alleles; Animals; Anura / genetics; Anura / physiology; Biological Evolution; Female; Genes, X-Linked; Genes, Y-Linked; Genetic Linkage; Genetic Markers; Genetic Speciation; Male; Recombination, Genetic / genetics; X Chromosome / genetics; Y Chromosome / genetics
topics (OpenAlex): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Genetic diversity and population structure; Animal Behavior and Reproduction
TL;DR: The notion that very low recombination rate may be sufficient to maintain homomorphism in sex chromosomes is supported. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2012 article

REPRODUCTIVE ISOLATION AND LOCAL ADAPTATION QUANTIFIED FOR A CHROMOSOME INVERSION IN A MALARIA MOSQUITO

Ayala, D., Guerrero, R. F., & Kirkpatrick, M. (2012, October 29). Evolution, Vol. 67, pp. 946–958.

By: D. Ayala *, R. Guerrero*  & M. Kirkpatrick *

author keywords: Anopheles; assortative mating; selection; postzygotic; prezygotic; speciation
MeSH headings : Adaptation, Biological / genetics; Animal Migration; Animals; Anopheles / genetics; Cameroon; Chromosome Inversion; Chromosomes, Insect / genetics; Ecosystem; Evolution, Molecular; Genetic Speciation; Heterozygote; Homozygote; Models, Genetic; Population / genetics; Reproductive Isolation; Selection, Genetic
topics (OpenAlex): Evolution and Genetic Dynamics; Malaria Research and Control; Mosquito-borne diseases and control
TL;DR: The first estimates from any organism for the total amount of reproductive isolation associated with an inversion segregating in natural populations are provided, suggesting that this one inversion can generate most of the genetic barriers needed for speciation. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2011 article

About PAR: The distinct evolutionary dynamics of the pseudoautosomal region

Otto, S. P., Pannell, J. R., Peichel, C. L., Ashman, T.-L., Charlesworth, D., Chippindale, A. K., … McAllister, B. F. (2011, September 1). Trends in Genetics, Vol. 9.

By: S. Otto *, J. Pannell *, C. Peichel *, T. Ashman *, D. Charlesworth *, A. Chippindale *, L. Delph *, R. Guerrero* , S. Scarpino *, B. McAllister*

MeSH headings : Algorithms; Animals; Chromosome Mapping; Evolution, Molecular; Genetic Loci; Genetic Variation; Humans; Models, Genetic; Recombination, Genetic; Sex Characteristics; Sex Chromosomes / genetics
topics (OpenAlex): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Chromosomal and Genetic Variations; Genetic diversity and population structure
TL;DR: The distribution and structure of PARs among animals and plants, the theoretical predictions concerning their evolutionary dynamics, the reasons for their persistence, and the diversity and content of genes that reside within them are reviewed. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2011 article

Coalescent patterns for chromosomal inversions in divergent populations

Guerrero, R. F., Rousset, F., & Kirkpatrick, M. (2011, December 26). Philosophical Transactions of the Royal Society B Biological Sciences, Vol. 2.

By: R. Guerrero* , F. Rousset * & M. Kirkpatrick *

author keywords: chromosomal inversions; coalescent models; local adaptation; recombination; genetic variation
MeSH headings : Adaptation, Biological; Alleles; Animals; Chromosome Inversion / genetics; Chromosomes / genetics; Computer Simulation; Evolution, Molecular; Genetic Drift; Genetic Speciation; Genetic Variation; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
topics (OpenAlex): Genetic diversity and population structure; Evolution and Genetic Dynamics; Chromosomal and Genetic Variations
TL;DR: It is found that ancient inversion polymorphisms cause genetic diversity to depart dramatically from neutral expectations, and coalescent models of neutral sites linked to an inversions polymorphism in two locally adapted populations provide the foundation for quantitative analyses of the roles that inversions have played in speciation. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2010 article

Patterns of Neutral Genetic Variation on Recombining Sex Chromosomes

Kirkpatrick, M., Guerrero, R. F., & Scarpino, S. V. (2010, February 2). Genetics, Vol. 4.

By: M. Kirkpatrick *, R. Guerrero*  & S. Scarpino *

MeSH headings : Animals; Evolution, Molecular; Female; Genetic Variation / genetics; Male; Models, Genetic; Mutation; Polymorphism, Genetic / genetics; Recombination, Genetic / genetics; Sex Chromosomes / genetics
topics (OpenAlex): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities; Chromosomal and Genetic Variations; Genetic Mapping and Diversity in Plants and Animals
TL;DR: This work develops coalescent models for neutral sites on sex chromosomes that recombine over much of their length and analyzes the standard neutral model, a model with polymorphic Y chromosomes under balancing selection, and the invasion of a neo-Y chromosome. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

Employment

Updated: September 15th, 2020 10:58

2020 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Biological Sciences

Education

Updated: September 15th, 2020 10:58

2007 - 2013

University of Texas at Austin Austin, TX, US
PhD Biology Integrative Biology

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