Works (38)

Updated: June 13th, 2024 05:01

2024 journal article

CAGI, the Critical Assessment of Genome Interpretation, establishes progress and prospects for computational genetic variant interpretation methods

GENOME BIOLOGY, 25(1).

By: S. Jain, C. Bakolitsa, S. Brenner, P. Radivojac, J. Moult, S. Repo, R. Hoskins, G. Andreoletti ...

Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 journal article

Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications

ELife.

By: R. Guerrero n, T. Dorji*, R. Harris*, M. Shoulders* & C. Ogbunugafor*

Source: ORCID
Added: June 1, 2024

2024 journal article

Evolutionary druggability for low-dimensional fitness landscapes toward new metrics for antimicrobial applications

ELife.

Source: ORCID
Added: June 8, 2024

2024 journal article

Genetic polymorphisms associated with adverse pregnancy outcomes in nulliparas

SCIENTIFIC REPORTS, 14(1).

By: R. Khan, R. Guerrero, R. Wapner, M. Hahn, A. Raja, A. Salleb-Aouissi, W. Grobman, H. Simhan ...

author keywords: Genetic association; Preeclampsia; Preterm birth; Gestational diabetes; Fetal death; Stillbirth; Pregnancy loss; Miscarriage
Sources: Web Of Science, NC State University Libraries
Added: June 11, 2024

2023 journal article

Epistasis and pleiotropy shape biophysical protein subspaces associated with drug resistance

PHYSICAL REVIEW E, 108(5).

By: C. Ogbunugafor*, R. Guerrero n, M. Miller-Dickson*, E. Shakhnovich* & M. Shoulders*

TL;DR: It is revealed that protein space is a deceptively complex notion, and that future applications to bioengineering should consider how interactions between amino acid substitutions manifest across different phenotypic subspaces. (via Semantic Scholar)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 28, 2024

2023 article

Epistasis meets pleiotropy in shaping biophysical protein subspaces associated with antimicrobial resistance

Ogbunugafor, C. B., Guerrero, R. F., Shakhnovich, E. I., & Shoulders, M. D. (2023, April 9).

TL;DR: It is revealed that protein space is a deceptively complex notion, and that the process of protein evolution and engineering should consider how interactions between amino acid substitutions manifest across different phenotypic subspaces. (via Semantic Scholar)
Source: ORCID
Added: April 10, 2023

2023 article

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, April 8).

By: R. Guerrero n, T. Dorji*, R. Harris*, M. Shoulders* & C. Ogbunugafor*

TL;DR: This framework can be applied to other datasets and pathogen-drug systems to understand which pathogen variants in a clinical setting are the most concerning (low variant vulnerability), and which drugs in a panel are most likely to be effective in an infection defined by standing genetic variation in the pathogen drug target (high drug applicability). (via Semantic Scholar)
Source: ORCID
Added: April 9, 2023

2023 article

Evolutionary druggability: leveraging low-dimensional fitness landscapes towards new metrics for antimicrobial applications

Guerrero, R. F., Dorji, T., Harris, R. M. M., Shoulders, M. D., & Ogbunugafor, C. B. (2023, November 30).

By: R. Guerrero n, T. Dorji*, R. Harris*, M. Shoulders* & C. Ogbunugafor*

Source: ORCID
Added: January 28, 2024

2023 article

Genetic Associations with Placental Proteins in Maternal Serum Identify Biomarkers for Hypertension in Pregnancy

Yan, Q., Blue, N. R., Truong, B., Zhang, Y., Guerrero, R. F., Liu, N., … Haas, D. M. (2023, May 30).

By: Q. Yan*, N. Blue*, B. Truong*, Y. Zhang*, R. Guerrero n, N. Liu*, M. Honigberg*, S. Parry* ...

TL;DR: Significant genetic associations with placental proteins ADAM-12, VEGF, and sFlt-1 are discovered, offering insights into their regulation during pregnancy, and Mendelian randomization analyses demonstrated evidence of causal relationships between placentalprotein links with gestational hypertensive disorders, potentially informing prevention and treatment strategies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 28, 2024

2023 article

Polygenic prediction of preeclampsia and gestational hypertension

Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, H. M. T., … Natarajan, P. (2023, May 29). NATURE MEDICINE, Vol. 5.

MeSH headings : Pregnancy; Female; Child; Humans; Hypertension, Pregnancy-Induced / genetics; Pre-Eclampsia / genetics; Pre-Eclampsia / prevention & control; Eclampsia; Hypertension; Aspirin; Risk Factors
TL;DR: The association of maternal DNA sequence variants with preeclampsia is tested in 20,064 cases and 703,117 control individuals and with gestational hypertension in 11,027 cases and 412,788 control individuals across discovery and follow-up cohorts using multi-ancestry meta-analysis. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 24, 2023

2023 article

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

Yan, Q., Guerrero, R. F., Khan, R. R., Surujnarine, A. A., Wapner, R. J., Hahn, M. W., … Haas, D. M. (2023, June 5).

By: Q. Yan*, R. Guerrero n, R. Khan*, A. Surujnarine*, R. Wapner*, M. Hahn*, A. Raja*, A. SallebAouissi* ...

TL;DR: GnuMoM2b is a valuable resource for extraction of pregnancy-related genetic results and shows the potential to facilitate meaningful discoveries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 28, 2024

2023 journal article

Searching and visualizing genetic associations of pregnancy traits by using GnuMoM2b

GENETICS, 225(2).

By: Q. Yan*, R. Guerrero n, R. Khan*, A. Surujnarine*, R. Wapner*, M. Hahn*, A. Raja*, A. Salleb-Aouissi* ...

author keywords: GWAS; PheWAS; adverse pregnancy outcomes; nuMoM2b
TL;DR: GnuMoM2b is a valuable resource for extraction of pregnancy-related genetic results and shows the potential to facilitate meaningful discoveries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2022 journal article

Association of Genetic Predisposition and Physical Activity With Risk of Gestational Diabetes in Nulliparous Women

JAMA NETWORK OPEN, 5(8).

By: K. Pagel*, H. Chu*, R. Ramola*, R. Guerrero n, J. Chung*, S. Parry*, U. Reddy*, R. Silver* ...

MeSH headings : Adult; Cohort Studies; Diabetes Mellitus, Type 2 / epidemiology; Diabetes Mellitus, Type 2 / genetics; Diabetes, Gestational / epidemiology; Diabetes, Gestational / genetics; Exercise; Female; Genetic Predisposition to Disease; Humans; Pregnancy
TL;DR: It is suggested that physical activity in early pregnancy is associated with reduced risk of GD and reversal of excess risk in genetically predisposed individuals, and PRS may have utility in identifying women for targeted interventions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 12, 2022

2022 article

Genetic Polymorphisms Associated with Adverse Pregnancy Outcomes in Nulliparas

Guerrero, R. F., Khan, R. R., Wapner, R. J., Hahn, M. W., Raja, A., Salleb-Aouissi, A., … Haas, D. M. (2022, March 1).

By: R. Guerrero n, R. Khan*, R. Wapner*, M. Hahn*, A. Raja*, A. Salleb-Aouissi*, W. Grobman*, H. Simhan* ...

TL;DR: This study identified genetic associations with gestational diabetes, pregnancy loss, and gestational length and confirms correlations of several previously identified variants with these APOs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: March 3, 2022

2022 article

Genome-wide meta-analysis identifies novel maternal risk variants and enables polygenic prediction of preeclampsia and gestational hypertension

Honigberg, M. C., Truong, B., Khan, R. R., Xiao, B., Bhatta, L., Vy, T. H., … Natarajan, P. (2022, December 1).

By: M. Honigberg*, B. Truong*, R. Khan*, B. Xiao*, L. Bhatta*, T. Vy*, R. Guerrero n, A. Schuermans* ...

TL;DR: Findings provide mechanistic insights into the hypertensive disorders of pregnancy and advance pregnancy risk stratification as identified loci highlight the role of natriuretic peptide signaling, angiogenesis, renal glomerular function, trophoblast development, and immune dysregulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: December 2, 2022

2022 article

The influence of genetic predisposition and physical activity on risk of Gestational Diabetes Mellitus in the nuMoM2b cohort

Pagel, K. A., Chu, H., Ramola, R., Guerrero, R. F., Chung, J. H., Parry, S., … Radivojac, P. (2022, March 9).

By: K. Pagel*, H. Chu*, R. Ramola*, R. Guerrero n, J. Chung*, S. Parry*, U. Reddy*, R. Silver* ...

TL;DR: In high-risk patient subgroups the addition of PRS resulted in increased risk of GDM diagnosis, suggesting the benefits of targeted PRS ascertainment to encourage early intervention. (via Semantic Scholar)
Source: ORCID
Added: March 12, 2022

2021 journal article

Inferring the Genetic Basis of Sex Determination from the Genome of a Dioecious Nightshade

MOLECULAR BIOLOGY AND EVOLUTION, 38(7), 2946–2957.

By: M. Wu*, D. Haak*, G. Anderson*, M. Hahn*, L. Moyle* & R. Guerrero n

Ed(s): M. Purugganan

author keywords: sex chromosome; sex evolution; genome assembly; dioecy; Solanum
MeSH headings : Biological Evolution; Gene Expression Regulation, Plant; Genome, Plant; Multigene Family; Pectins / genetics; Sex Determination Processes / genetics; Solanum / genetics
TL;DR: The first genome sequence of a dioecious Solanum is generated and it is inferred that males in this species are the heterogametic sex and observed patterns of gene-family evolution specific to S. appendiculatum consistently implicate a suite of genes from the regulatory network controlling pectin degradation and modification in the expression of sex. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
15. Life on Land (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: April 24, 2021

2020 article

The ortholog conjecture revisited: the value of orthologs and paralogs in function prediction

Stamboulian, M., Guerrero, R. F., Hahn, M. W., & Radivojac, P. (2020, July). BIOINFORMATICS, Vol. 36, pp. 219–226.

By: M. Stamboulian*, R. Guerrero n, M. Hahn* & P. Radivojac*

MeSH headings : Animals; Base Sequence; Evolution, Molecular; Genome; Humans; Mice; Proteins / genetics
TL;DR: The results support the view that the types of homologs used for function transfer are largely irrelevant to the task of function prediction, and aim to maximize the amount of data used for this task, regardless of whether it comes from orthologs or paralogs, is most likely to lead to higher prediction accuracy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2019 journal article

CAGI SickKids challenges: Assessment of phenotype and variant predictions derived from clinical and genomic data of children with undiagnosed diseases

Human Mutation, 40(9), 1373–1391.

By: L. Kasak*, J. Hunter*, R. Udani*, C. Bakolitsa*, Z. Hu*, A. Adhikari*, G. Babbi*, R. Casadio* ...

author keywords: CAGI; pediatric rare disease; phenotype prediction; SickKids; variant interpretation; whole-genome sequencing data
MeSH headings : Adolescent; Child; Child, Preschool; Computational Biology / methods; Computer Simulation; Databases, Genetic; Female; Genetic Predisposition to Disease; Genetic Variation; Humans; Male; Phenotype; Undiagnosed Diseases / diagnosis; Undiagnosed Diseases / genetics; Whole Genome Sequencing
TL;DR: CAGI4 and CAGI5 participants were provided with WGS data and clinical descriptions of 25 and 24 undiagnosed patients from the SickKids Genome Clinic Project, respectively and Predictors were asked to identify primary and secondary causal variants. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2019 journal article

Proteostasis Environment Shapes Higher-Order Epistasis Operating on Antibiotic Resistance

Genetics, 212(2), 565–575.

author keywords: epistasis; proteostasis; antibiotic resistance
MeSH headings : Chlamydia muridarum / drug effects; Chlamydia muridarum / genetics; Chlamydia muridarum / metabolism; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Epistasis, Genetic / drug effects; Escherichia coli / drug effects; Escherichia coli / genetics; Escherichia coli / metabolism; Genetic Association Studies; Genetic Pleiotropy; Listeria / drug effects; Listeria / genetics; Listeria / metabolism; Mutation; Polymorphism, Single Nucleotide; Proteostasis; Tetrahydrofolate Dehydrogenase / genetics
TL;DR: This study disentangle the interactions between different protein quality control genetic backgrounds and two sets of mutations and improves on generic observations that epistasis is widespread by discussing how patterns of epistasis can be partly explained by specific interactions between mutations in an essential enzyme and genes associated with the proteostasis environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2018 journal article

Complex selection on a regulator of social cognition: Evidence of balancing selection, regulatory interactions and population differentiation in the prairie vole Avpr1a locus

Molecular Ecology.

By: A. Berrio*, R. Guerrero*, G. Aglyamova*, M. Okhovat*, M. Matz* & S. Phelps*

author keywords: adaptation; behaviour/social evolution; gene regulation; population genetics-empirical; sexual fidelity
MeSH headings : Alleles; Animals; Arvicolinae / genetics; Arvicolinae / physiology; Brain / physiology; Cognition / physiology; Genetic Variation; Microsatellite Repeats / genetics; Receptors, Vasopressin / genetics; Sexual Behavior, Animal / physiology; Social Behavior
TL;DR: The data suggest that complex selection on Avpr1a locus favours specific combinations of regulatory polymorphisms, maintains the resulting alleles at population‐specific frequencies, and may contribute to unique patterns of spatial cognition and sexual fidelity among populations. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2018 journal article

Quantifying the risk of hemiplasy in phylogenetic inference

Proceedings of the National Academy of Sciences, 115(50), 12787–12792.

By: R. Guerrero* & M. Hahn*

author keywords: homoplasy; convergence; comparative methods; multispecies coalescent
MeSH headings : Animals; Evolution, Molecular; Genome / genetics; Models, Genetic; Phylogeny; Primates; Probability; Risk Factors
TL;DR: Hemiplasy is as likely—or more likely—than homoplasy for a wide range of conditions, even when levels of discordance are low, and is likely to explain many apparent cases of convergent evolution even when the fraction of discordant regions is low. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2017 journal article

Pervasive antagonistic interactions among hybrid incompatibility loci

PLOS Genetics, 13(6), e1006817.

By: R. Guerrero*, C. Muir*, S. Josway* & L. Moyle*

Ed(s): C. Köhler

MeSH headings : Chromosome Mapping; Chromosomes, Plant / genetics; Epistasis, Genetic; Fertility / genetics; Genotype; Hybridization, Genetic; Solanum lycopersicum / genetics; Solanum lycopersicum / growth & development; Models, Genetic; Phenotype; Plant Infertility / genetics; Pollen / genetics; Quantitative Trait Loci / genetics; Reproductive Isolation; Seeds / genetics; Species Specificity
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2017 journal article

Speciation as a Sieve for Ancestral Polymorphism

Molecular Ecology, 8.

By: R. Guerrero* & M. Hahn*

author keywords: allopatric speciation; balancing selection; differential gene flow; genomic divergence
MeSH headings : Alleles; Gene Flow; Gene Frequency; Genetic Speciation; Genetics, Population; Genomics; Models, Genetic; Polymorphism, Genetic
TL;DR: How ancestral balanced polymorphisms can be “sieved” by the speciation process, which sorts them unequally across descendant lineages is discussed. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2017 journal article

Topological features of a gene co-expression network predict patterns of natural diversity in environmental response

Proceedings of the Royal Society B: Biological Sciences, 284(1856), 20170914.

By: D. Marais*, R. Guerrero*, J. Lasky* & S. Scarpino*

author keywords: gene by environment interaction; gene regulatory network; Arabidopsis thaliana; abiotic stress; drought; cold
MeSH headings : Adaptation, Physiological / genetics; Arabidopsis / genetics; Arabidopsis / physiology; Cold Temperature; Droughts; Gene Expression Regulation, Plant; Gene Regulatory Networks
TL;DR: This work investigated the network topology of genes putatively involved in local adaptation to two abiotic stressors—drought and cold—in Arabidopsis thaliana and suggested that the gene-interaction topologies for both cold and drought stress response are non-random. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2017 journal article

Transcriptomic analysis links gene expression to unilateral pollen-pistil reproductive barriers.

BMC Plant Biology, 4.

Rafael Guerrero

author keywords: Interspecific reproductive barriers; Interpopulation interactions; Plant mating system; Pollen-pistil transcriptomes; Self-incompatibility; Solanum habrochaites; Unilateral incompatibility; Wild tomato species
MeSH headings : Flowers / genetics; Flowers / physiology; Gene Expression; Gene Expression Profiling; Genes, Plant; Pollen / genetics; Pollen / physiology; Solanum / genetics; Solanum / physiology
TL;DR: Gene expression analysis of reproductive tissues allowed us to better understand the molecular basis of interpopulation incompatibility at the level of pollen-pistil interactions and highlighted specific genes, including those in ROS signaling pathways that warrant further study in investigations of UI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2016 journal article

Genome-wide patterns of regulatory divergence revealed by introgression lines

Evolution, 70(3), 696–706.

By: R. Guerrero*, A. Posto*, L. Moyle* & M. Hahn*

author keywords: cis-Regulation; gene expression; hybrid misregulation; trans-regulation; Solanum lycopersicum; Solanum pennellii
MeSH headings : Gene Expression Regulation, Plant; Hybridization, Genetic; Plant Infertility; Regulatory Elements, Transcriptional; Solanum / classification; Solanum / genetics; Transcriptome
TL;DR: The mechanisms of divergence in genome-wide patterns of gene expression between the nightshades Solanum pennellii and S. lycopersicum are inferred and it is found that cis- and frans-regulatory changes have had qualitatively similar contributions to divergence in this clade, unlike results from other systems. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2016 journal article

Molecular mechanisms of postmating prezygotic reproductive isolation uncovered by transcriptome analysis

Molecular Ecology, 25(11), 2592–2608.

By: J. Pease*, R. Guerrero*, N. Sherman*, M. Hahn* & L. Moyle*

author keywords: hybridization; reproductive isolation; speciation; transcriptomics
MeSH headings : Chromosome Mapping; Crosses, Genetic; Gene Expression Profiling; Genes, Plant; Phenotype; Pollen / genetics; RNA, Plant / genetics; Reproduction / genetics; Reproductive Isolation; Solanum / genetics; Solanum / physiology; Transcriptome
TL;DR: This study examines changes in gene expression that accompany the expression of ‘unilateral incompatibility’ (UI), a postmating prezygotic barrier in which fertilization is prevented by gamete rejection in the reproductive tract, but is successful in the reciprocal crossing direction. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2014 journal article

LOCAL ADAPTATION AND THE EVOLUTION OF CHROMOSOME FUSIONS

Evolution, 68(10), 2747–2756.

By: R. Guerrero* & M. Kirkpatrick*

author keywords: Coalescent; population divergence; rearrangements; recombination; Robertsonian translocations; selection
MeSH headings : Adaptation, Physiological / genetics; Alleles; Biological Evolution; Chromosomes / genetics; Genetic Fitness; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
TL;DR: Local adaptation could explain the evolution of many of chromosome fusions, which are some of the most common chromosome rearrangements in nature. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2014 journal article

Matrix inversions for chromosomal inversions: A method to construct summary statistics in complex coalescent models

Theoretical Population Biology.

Rafael Guerrero

author keywords: Chromosomal inversions; Coalescent models; Local adaptation; Gametic disequilibrium; Approximate Bayesian computation
MeSH headings : Animals; Bayes Theorem; Chromosome Inversion / statistics & numerical data; Linkage Disequilibrium; Models, Genetic; Models, Statistical
TL;DR: A method to construct summary statistics in such complex population structure models by analyzing the disequilibrium between two sites within an inversion and providing an estimator of the distinct recombination rate between these two sites in homokaryotype and heterokaryotypes is defined. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2014 journal article

Signatures of sex-antagonistic selection on recombining sex chromosomes.

Genetics, 6.

Rafael Guerrero

MeSH headings : Animals; Biological Evolution; Female; Genetic Variation; Linkage Disequilibrium; Male; Models, Genetic; Selection, Genetic; Sex Chromosomes / genetics; Silene / genetics
TL;DR: This work uses coalescent models to characterize the patterns of polymorphism expected within and divergence between recombining X and Y (or Z and W) sex chromosomes and shows how the pattern of divergence is altered when the SA polymorphism or the sex-determining region was recently established. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2014 journal article

Strong reinforcing selection in a Texas wildflower.

Current Biology : CB, 9.

Rafael Guerrero

MeSH headings : Flowers / genetics; Flowers / physiology; Magnoliopsida / genetics; Magnoliopsida / physiology; Models, Genetic; Pigmentation; Reproductive Isolation; Selection, Genetic
TL;DR: This work quantifies the strength of reinforcing selection in the Texas wildflower Phlox drummondii using a strategy that weds a population genetic model with field data and finds that selection on flower color genes generated by reinforcement is exceptionally strong. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2013 journal article

A sequential coalescent algorithm for chromosomal inversions.

Heredity, 9.

Rafael Guerrero

author keywords: inversions; coalescent; simulation; recombination; linkage disequilibrium; ancestral recombination graph
MeSH headings : Algorithms; Chromosome Inversion; Computer Simulation; Genetics, Population; Linkage Disequilibrium; Models, Genetic; Recombination, Genetic
TL;DR: The SMC algorithm is fast, memory-efficient and accurate, making it feasible to simulate large inversions in large populations for the first time, and enables studies of patterns of genetic variation and tests of hypotheses that were previously intractable. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2012 journal article

Coalescent patterns for chromosomal inversions in divergent populations.

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 2.

Rafael Guerrero

author keywords: chromosomal inversions; coalescent models; local adaptation; recombination; genetic variation
MeSH headings : Adaptation, Biological; Alleles; Animals; Chromosome Inversion / genetics; Chromosomes / genetics; Computer Simulation; Evolution, Molecular; Genetic Drift; Genetic Speciation; Genetic Variation; Genetics, Population; Models, Genetic; Recombination, Genetic; Selection, Genetic
TL;DR: It is found that ancient inversion polymorphisms cause genetic diversity to depart dramatically from neutral expectations, and coalescent models of neutral sites linked to an inversions polymorphism in two locally adapted populations provide the foundation for quantitative analyses of the roles that inversions have played in speciation. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2012 journal article

Cryptic recombination in the ever-young sex chromosomes of Hylid frogs.

Journal of Evolutionary Biology, 10.

Rafael Guerrero

author keywords: approximate Bayesian computation; homomorphic sex chromosomes; Hyla; recombination suppression
MeSH headings : Alleles; Animals; Anura / genetics; Anura / physiology; Biological Evolution; Female; Genes, X-Linked; Genes, Y-Linked; Genetic Linkage; Genetic Markers; Genetic Speciation; Male; Recombination, Genetic / genetics; X Chromosome / genetics; Y Chromosome / genetics
TL;DR: The notion that very low recombination rate may be sufficient to maintain homomorphism in sex chromosomes is supported. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2012 journal article

REPRODUCTIVE ISOLATION AND LOCAL ADAPTATION QUANTIFIED FOR A CHROMOSOME INVERSION IN A MALARIA MOSQUITO

Evolution, 67(4), 946–958.

By: D. Ayala*, R. Guerrero* & M. Kirkpatrick*

author keywords: Anopheles; assortative mating; selection; postzygotic; prezygotic; speciation
MeSH headings : Adaptation, Biological / genetics; Animal Migration; Animals; Anopheles / genetics; Cameroon; Chromosome Inversion; Chromosomes, Insect / genetics; Ecosystem; Evolution, Molecular; Genetic Speciation; Heterozygote; Homozygote; Models, Genetic; Population / genetics; Reproductive Isolation; Selection, Genetic
TL;DR: The first estimates from any organism for the total amount of reproductive isolation associated with an inversion segregating in natural populations are provided, suggesting that this one inversion can generate most of the genetic barriers needed for speciation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: ORCID
Added: September 15, 2020

2011 journal article

About PAR: the distinct evolutionary dynamics of the pseudoautosomal region.

Trends in Genetics : TIG, 9.

Rafael Guerrero

MeSH headings : Algorithms; Animals; Chromosome Mapping; Evolution, Molecular; Genetic Loci; Genetic Variation; Humans; Models, Genetic; Recombination, Genetic; Sex Characteristics; Sex Chromosomes / genetics
TL;DR: The distribution and structure of PARs among animals and plants, the theoretical predictions concerning their evolutionary dynamics, the reasons for their persistence, and the diversity and content of genes that reside within them are reviewed. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

2010 journal article

Patterns of neutral genetic variation on recombining sex chromosomes.

Genetics, 4.

Rafael Guerrero

MeSH headings : Animals; Evolution, Molecular; Female; Genetic Variation / genetics; Male; Models, Genetic; Mutation; Polymorphism, Genetic / genetics; Recombination, Genetic / genetics; Sex Chromosomes / genetics
TL;DR: This work develops coalescent models for neutral sites on sex chromosomes that recombine over much of their length and analyzes the standard neutral model, a model with polymorphic Y chromosomes under balancing selection, and the invasion of a neo-Y chromosome. (via Semantic Scholar)
Source: ORCID
Added: September 15, 2020

Employment

Updated: September 15th, 2020 10:58

2020 - present

North Carolina State University Raleigh, NC, US
Assistant Professor Biological Sciences

Education

Updated: September 15th, 2020 10:58

2007 - 2013

University of Texas at Austin Austin, TX, US
PhD Biology Integrative Biology

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