Ruben G. Carbonell
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Works (165)
Updated: April 30th, 2024 05:02
2024 journal article
Mixed-mode size-exclusion silica resin for polishing human antibodies in flow-through mode
Journal of Chromatography A, 1720, 464772.
author keywords: Antibody fragments; Product polishing; Mixed -mode ligands; Silica resin; Flow -through chromatography
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: April 29, 2024
2024 journal article
Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant
JOURNAL OF CHROMATOGRAPHY A, 1718.
author keywords: Multimodal ligand; Membrane chromatography; Nonwoven membranes; Single-chain variable fragment (scFv); Pichia pastoris fermentation
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 8, 2024
2023 article
Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review
Lavoie, J., Fan, J., Pourdeyhimi, B., Boi, C., & Carbonell, R. G. (2023, May 31). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 5.
author keywords: downstream purification; fibrous systems; membrane adsorbers; membrane chromatography; nonwovens; product capture and polishing
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023
2023 journal article
Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane
Separation and Purification Technology, 317, 123920.
author keywords: Salt-tolerant multimodal ligand; Membrane adsorber; Membrane chromatography; Nonwoven membranes; Monoclonal antibodies (mAbs); High-risk HCPs
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: June 5, 2023
2022 article
A direct comparison between membrane adsorber and packed column chromatography performance (vol 1612, 460629, 2020)
Boi, C., Malavasi, A., Carbonell, R. G., & Gilleskie, G. (2022, March 15). JOURNAL OF CHROMATOGRAPHY A, Vol. 1666.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022
2022 journal article
Development of peptide affinity ligands for the purification of polyclonal and monoclonal Fabs from recombinant fluids
JOURNAL OF CHROMATOGRAPHY A, 1687.
author keywords: Peptide ligands; Affinity chromatography; Fragment antigen binding; Monoclonal antibodies; Cell culture harvests
MeSH headings : Cricetinae; Animals; Humans; Cricetulus; Ligands; CHO Cells; Molecular Docking Simulation; Protein Binding; Peptides / chemistry; Antibodies, Monoclonal; Chromatography, Affinity
TL;DR:
The de novo discovery of peptide ligands that target different regions of human Fab and enable product release under mild conditions are discovered and afforded values of yield and purity comparable to those provided by Protein L resins.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
2022 journal article
Integrated in silico and experimental discovery of trimeric peptide ligands targeting Butyrylcholinesterase
COMPUTATIONAL BIOLOGY AND CHEMISTRY, 102.
author keywords: Acetylcholinesterase; Butyrylcholinesterase; Purification; Molecular docking; Affinity ligands
MeSH headings : Butyrylcholinesterase / metabolism; Cholinesterase Inhibitors / chemistry; Ligands; Molecular Docking Simulation; Peptides
TL;DR:
A marked anti-correlated conformational movement governed by the ionic strength and pH of the aqueous environment is revealed, which ultimately controls BChE binding and release during chromatographic purification and provides useful guidance for ligand design and affinity maturation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 17, 2023
2022 journal article
Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes
Membranes, 12(10), 944.
author keywords: adeno-associated virus (AAV); viral vector purification; nonwovens; membrane adsorber; anion exchange; cation exchange; membrane chromatography
TL;DR:
A strong anion-exchange membrane was developed by UV grafting glycidyl methacrylate on a polybutylene terephthalate nonwoven followed by functionalization with triethylamine, resulting in a quaternary amine ligand (AEX-TEA membrane) that exhibited a high AAV2 binding capacity and achieved excellent DNA clearance and a recovery of infectivity higher that that reported using ion-ex exchange resin chromatography.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: November 14, 2022
2022 article
Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents
Sripada, S. A., Chu, W., Williams, T. I., Teten, M. A., Mosley, B. J., Carbonell, R. G., … Menegatti, S. (2022, April 22). BIOTECHNOLOGY AND BIOENGINEERING, Vol. 119.
Contributors: S. Sripada n, W. Chu n, T. Williams n , M. Teten n, B. Mosley n, n, A. Lenhoff *, S. Cramer *
author keywords: CHO; flow-through chromatography; host cell proteins; monoclonal antibodies; peptide-based adsorbents
MeSH headings : Animals; Antibodies, Monoclonal / chemistry; CHO Cells; Cell Culture Techniques; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Peptides / chemistry; Proteomics / methods
TL;DR:
An ensemble of peptide ligands that target the HCPs in Chinese hamster ovary (CHO) cell culture fluids and enable mAb purification via flow‐through affinity chromatography are introduced and their integration into LigaGuard™, an affinity adsorbent featuring an equilibrium binding capacity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 10, 2022
2021 article
Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests
PROTEOMIC PROFILING, 2 EDITION, Vol. 2261, pp. 489–506.
Contributors: R. Lavoie n, T. Williams n , R. Blackburn *, n & S. Menegatti n
author keywords: Proteomics; Mass spectrometry; Host cell proteins; Monoclonal antibodies; Peptide ligands; Flow-through chromatography
MeSH headings : Animals; CHO Cells; Cricetulus; Enzyme-Linked Immunosorbent Assay; Humans; Ligands; Microscopy, Fluorescence; Peptide Library; Peptides / metabolism; Protein Binding; Proteins / isolation & purification; Proteins / metabolism; Proteomics; Solid Phase Extraction; Tandem Mass Spectrometry
TL;DR:
This work describes the development of HCP-binding peptide ligands, especially focusing on the steps of peptide selection via library screening and quantification of H CP removal via proteomics by mass spectrometry.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 8, 2021
2021 journal article
Iminodiacetic Acid (IDA) Cation-Exchange Nonwoven Membranes for Efficient Capture of Antibodies and Antibody Fragments
Membranes, 11(7), 530.
author keywords: membrane adsorbers; membrane chromatography; nonwoven membranes; cation-exchange; UV grafting; monoclonal antibodies (mAbs); single-chain variable fragment (scFv)
TL;DR:
There is significant evidence that this weak cation-exchange nonwoven fabric platform might be a suitable alternative to packed resin chromatography for low-cost, higher productivity manufacturing of therapeutic mAbs and antibody fragments.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 2, 2021
2021 journal article
Nonwoven Ion-Exchange Membranes with High Protein Binding Capacity for Bioseparations
Membranes, 11(3), 181.
author keywords: nonwoven membrane; UV-grafting; membrane chromatography; ion-exchange membrane; protein purification; membrane adsorbers
TL;DR:
The preparation and characterization of UV-grafted polybutylene terepthalate ion exchange nonwoven membranes for chromatographic purification of biomolecules indicate that these membranes have significant potential for use in downstream purifying of biology.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: April 19, 2021
2020 journal article
Novel peptide ligands for antibody purification provide superior clearance of host cell protein impurities
JOURNAL OF CHROMATOGRAPHY A, 1625.
author keywords: Peptide affinity ligands; Protein A; mAb purification; Affinity chromatography; Peptide design
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / isolation & purification; Antibodies, Monoclonal / metabolism; CHO Cells; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Ligands; Peptides / chemical synthesis; Peptides / chemistry; Peptides / metabolism; Protein Binding; Staphylococcal Protein A / chemistry; Staphylococcal Protein A / metabolism
TL;DR:
WQRHGI-WorkBeads resin was finally characterized by purification of a monoclonal antibody from a Chinese Hamster Ovary cell culture harvest, affording a remarkable HCP LRV of 2.7, and consistent product yield and purity over 100 chromatographic cycles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020
2020 journal article
Removal of host cell proteins from cell culture fluids by weak partitioning chromatography using peptide-based adsorbents
SEPARATION AND PURIFICATION TECHNOLOGY, 257.
Contributors: R. Lavoie n, W. Chu n, J. Lavoie n, Z. Hetzler n, T. Williams n , n, S. Menegatti n
author keywords: Host cell proteins; Monoclonal antibodies; Flow-through chromatography; Weak partitioning mode; Polishing; Proteomics; Peptide ligands
TL;DR:
Proteomic analysis of the effluents demonstrated that 6HP+4MP-Toyopearl adsorbent removes HCPs known for their immunogenicity or IgG co-elution or degradation, demonstrating the potential of these peptide-based resins as HCP scrubbers in mAb purification processes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 11, 2021
2019 journal article
A direct comparison between membrane adsorber and packed column chromatography performance
Journal of Chromatography A, 1612, 460629.
author keywords: Chromatography; Membrane adsorber; Packed column; Binding capacity; Productivity
MeSH headings : Adsorption; Anion Exchange Resins; Chromatography, Ion Exchange / methods; Proteins / isolation & purification; Serum Albumin, Bovine / isolation & purification
TL;DR:
The comparison was performed using anion exchange media with the same ligand immobilized on the adsorbing surface, namely the strong Q quaternary ammonium group, R-CH2-N+-(CH3)3, and bovine serum albumin as a model protein to confirm the better performance of membrane chromatography at high flow rates.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: March 10, 2020
2019 journal article
Multiplexed Competitive Screening of One-Bead-One-Component Combinatorial Libraries Using a ClonePix 2 Colony Sorter
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(20).
author keywords: library screening; bioactive peptides; ligand development; affinity chromatography; affinity ligand; ClonePix 2
MeSH headings : Animals; Cell Line; Chromatography, Affinity / methods; Drug Discovery / methods; Humans; Immunoglobulin G; Ligands; Optical Imaging / methods; Peptide Library; Small Molecule Libraries
TL;DR:
This work presents a method for multiplexed solid-phase peptide library screening using a ClonePix 2 Colony Picker that integrates orthogonal fluorescent labeling for positive selection against a target protein and negative selection against competitor species with semi-quantitative tracking of target vs. competitor binding for every library bead.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2019
2019 journal article
Optimization of Sequence, Display, and Mode of Operation of IgG-Binding Peptide Ligands to Develop Robust, High-Capacity Affinity Adsorbents That Afford High IgG Product Quality
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1).
author keywords: affinity chromatography; peptide ligand; antibody purification; binding capacity; process optimization; aggregate removal
TL;DR:
The use of peptide ligand HWRGWV and its cognate sequences to develop affinity adsorbents that compete with Protein A in terms of binding capacity and quality of the eluted product demonstrate the potential of peptides as alternative to Protein A for the purification of therapeutic antibodies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 11, 2019
2019 journal article
Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(7).
author keywords: therapeutic antibodies; host cell proteins; protein purification; peptide ligands
MeSH headings : Animals; CHO Cells; Chromatography, Affinity; Chromatography, Liquid; Cricetinae; Cricetulus; Humans; Peptides / chemistry; Peptides / isolation & purification; Proteomics / methods
TL;DR:
Development of synthetic peptide ligands capable of capturing a broad spectrum of Chinese hamster ovary (CHO) HCPs with a combination of peptide species that allow for advanced mixed-mode binding is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 6, 2019
2019 journal article
Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis
BIOTECHNOLOGY AND BIOENGINEERING, 117(2), 438–452.
Contributors: R. Lavoie n, A. Fazio n, T. Williams n , n & S. Menegatti n
author keywords: host cell proteins; monoclonal antibodies; polishing; peptide ligands; protein purification
MeSH headings : Animals; Antibodies, Monoclonal / isolation & purification; CHO Cells; Cricetinae; Cricetulus; Ligands; Peptides / chemistry; Peptides / metabolism; Protein Binding; Proteins / analysis; Proteins / chemistry; Proteins / isolation & purification; Proteins / metabolism; Proteomics / methods; Recombinant Proteins / isolation & purification
TL;DR:
A family of synthetic peptides that target HCPs and exhibit low binding to IgG product are developed and found that these peptide ligands exhibit superior HCP binding capability compared to those of the benchmark commercial resins commonly used in mAb purification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 2, 2019
2019 journal article
Use of a Branched Linker for Enhanced Biosensing Properties in IgG Detection from Mixed Chinese Hamster Ovary Cell Cultures
BIOCONJUGATE CHEMISTRY, 30(3), 815–825.
MeSH headings : Adsorption; Amino Acid Sequence; Animals; Biosensing Techniques; CHO Cells; Complex Mixtures; Cricetinae; Cricetulus; Immunoglobulin G / analysis; Kinetics; Peptides / chemistry
TL;DR:
The branched amines increased the overall sensitivity and selectivity for IgG adsorption from complex mixtures of Chinese hamster ovary supernatant (CHO) and regeneration studies were carried out.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: April 9, 2019
2018 journal article
Purification of human erythropoietin by affinity chromatography using cyclic peptide ligands
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1085, 1–12.
author keywords: Cyclic peptide ligand; Erythropoietin purification; Affinity chromatography; Chinese hamster ovary; Pichia pastoris
MeSH headings : Animals; CHO Cells; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Erythropoietin / analysis; Erythropoietin / chemistry; Erythropoietin / isolation & purification; Erythropoietin / metabolism; Humans; Hydrogen-Ion Concentration; Peptides, Cyclic / chemistry; Peptides, Cyclic / metabolism; Pichia; Proteins
TL;DR:
Results compare well with values obtained using wheat germ agglutinin agarose and clearly indicate the potential of the cyclic peptide resins as a viable tool for rHuEPO purification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2018 journal article
Silica resins and peptide ligands to develop disposable affinity adsorbents for antibody purification
BIOCHEMICAL ENGINEERING JOURNAL, 145, 53–61.
author keywords: Silica resins; Peptide ligands; Monoclonal antibodies; Llama antibodies; Rabbit antibodies
TL;DR:
It is demonstrated that porous silica, a non-traditional substrate for protein purification, shows great promise as potentially single-use affinity adsorbent forprotein purification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 13, 2019
2017 journal article
Design, selection, and development of cyclic peptide ligands for human erythropoietin
JOURNAL OF CHROMATOGRAPHY A, 1500, 105–120.
author keywords: Erythropoietin; Cyclic peptide ligands; Ligand screening; Affinity chromatography; Affinity maturation; In-silico docking
MeSH headings : Amino Acid Sequence; Amino Acids / chemistry; Erythropoietin / chemistry; Humans; Kinetics; Ligands; Molecular Sequence Data; Peptides, Cyclic / chemistry; Peptides, Cyclic / isolation & purification; Protein Binding
TL;DR:
Mutagenesis studies performed on FSLLSH with natural and non-natural amino acid substitutions led to the identification of critical EPO-binding determinants, and the discovery of new peptide ligands that facilitate EPO recovery.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Design of protease-resistant peptide ligands for the purification of antibodies from human plasma
Journal of Chromatography A, 1445, 93–104.
author keywords: Peptide affinity ligands; Polyclonal antibodies; Affinity chromatography; Proteolysis; Protease; Molecular docking
MeSH headings : Animals; Antibodies / isolation & purification; Binding Sites; Blood Chemical Analysis / methods; Chromatography, Affinity; Chymotrypsin / metabolism; Humans; Ligands; Peptides / chemistry; Protein Binding; Trypsin / metabolism
TL;DR:
A strategy is presented for developing variants of peptide ligands with enhanced biochemical stability for the purification of antibodies from animal sera and higher selectivity than the original sequences, due to electrical neutrality.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2016 journal article
Reducing diffusion limitations in Ion exchange grafted membranes using high surface area nonwovens
JOURNAL OF MEMBRANE SCIENCE, 514, 53–64.
author keywords: UV grafting; Islands-in-the-sea nonwoven; Diffusion limited; Ion exchange protein capture; Shrinking core
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Affinity interactions of human immunoglobulin G with short peptides: role of ligand spacer on binding, kinetics, and mass transfer
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 408(7), 1829–1841.
author keywords: Peptide ligands; Immunoglobulin G; Peptide HWRGWV; Spacer arms; Quartz crystal microbalance
MeSH headings : Adsorption; Amino Acid Sequence; Humans; Immunoglobulin G / metabolism; Kinetics; Ligands; Peptides / chemistry; Peptides / metabolism; Polyethylene Glycols / chemistry; Protein Binding; Quartz Crystal Microbalance Techniques / methods; Silicon Dioxide / chemistry
TL;DR:
Light was shed on interfacial effects important for detection and bioseparation by following the shifts in frequency and energy dissipation in a quartz crystal microbalance, as well as thermodynamic and kinetics parameters.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
7. Affordable and Clean Energy
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Preparation and characterization of anion exchange adsorptive nonwoven membranes with high protein binding capacity
JOURNAL OF MEMBRANE SCIENCE, 493, 349–359.
author keywords: Anion exchange membrane; Protein purification; Nonwoven surface modification; High protein binding capacity; hIgG separation
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Application of peptide chromatography for the isolation of antibodies from bovine skim milk, acid whey and colostrum
FOOD AND BIOPRODUCTS PROCESSING, 92(C2), 199–207.
author keywords: Protein A mimetic; Peptide ligands; Affinity chromatography; Bovine immunoglobulins; HWRGWV hexamer peptide; Colostrum
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Comprehensive Hands-on Training for Influenza Vaccine Manufacturing: A WHO-BARDA-BTEC Partnership for Global Workforce Development
BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 42(5), 414–419.
author keywords: workforce development; developing countries vaccine manufacturers; influenza vaccine; global vaccine capacity-building; active learning; cGMP manufacturing
MeSH headings : Capacity Building / methods; Education, Continuing / methods; Humans; Influenza Vaccines / biosynthesis; Influenza Vaccines / immunology; Internet; Program Development / methods; Reproducibility of Results; Technology, Pharmaceutical / education; Technology, Pharmaceutical / methods; United States; United States Dept. of Health and Human Services; World Health Organization
TL;DR:
The Biomanufacturing Training and Education Center at North Carolina State University has addressed the need for training for staff supporting operations within vaccine production facilities by developing and delivering a comprehensive training program, consisting of three courses: Fundamentals of cGMP Influenza Vaccine Manufacturing, Advanced Upstream Processes for Influenza vaccine Manufacturing, and Advanced Downstream processeses for influenza vaccine Manufacturing.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Dynamic and equilibrium performance of sensors based on short peptide ligands for affinity adsorption of human IgG using surface plasmon resonance
BIOSENSORS & BIOELECTRONICS, 58, 380–387.
author keywords: Hexamer; Protein A; Human immunoglobulin G; Self-assembled monolayers; Adsorption rate constant; Desorption rate constant
MeSH headings : Adsorption; Antibody Affinity / immunology; Binding Sites; Biosensing Techniques / instrumentation; Equipment Design; Equipment Failure Analysis; Immunoglobulin G / chemistry; Immunoglobulin G / immunology; Peptides / chemistry; Peptides / immunology; Protein Binding; Protein Interaction Mapping / instrumentation; Surface Plasmon Resonance / instrumentation
TL;DR:
This paper characterizes the potential of novel hexameric peptide ligands for on-line IgG detection in bioprocesses and finds that the peptide-IgG binding was reaction controlled, however the protein A-IGG binding mechanism was partially mass transfer (diffusion) controlled.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Effects of Composition of Oligo(ethylene glycol)-Based Mixed Monolayers on Peptide Grafting and Human Immunoglobulin Detection
JOURNAL OF PHYSICAL CHEMISTRY C, 118(10), 5361–5373.
TL;DR:
The specificity toward IgG was optimal for peptides grafted on SAMs prepared from 10% EG6NH2 precursor solution, even though this surface did not have the highest number of peptides per unit area.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
A new strategy for ultralow biofouling membranes: Uniform and ultrathin hydrophilic coatings using liquid carbon dioxide
JOURNAL OF MEMBRANE SCIENCE, 440, 88–97.
author keywords: Hydrophilization; Liquid carbon dioxide; Coating; Biofouling
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Bioactive Cellulose Nanofibrils for Specific Human IgG Binding
BIOMACROMOLECULES, 14(12), 4161–4168.
MeSH headings : Adsorption; Biosensing Techniques; Cellulose / chemistry; Cellulose / ultrastructure; Chromatography, Affinity; Humans; Immobilized Proteins; Immunoglobulin G / chemistry; Immunoglobulin G / isolation & purification; Kinetics; Microscopy, Atomic Force; Nanofibers / chemistry; Nanofibers / ultrastructure; Peptide Fragments / chemistry; Polymerization; Polymethacrylic Acids / chemistry; Protein Binding; Quartz Crystal Microbalance Techniques; Signal-To-Noise Ratio; Surface Properties
TL;DR:
The effects of initiator concentration and thickness of poly(AMA-co-HEMA) layer on hIgG adsorption were investigated in the developed systems, which exhibited high signal-to-noise response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Reversible cyclic peptide libraries for the discovery of affinity ligands
Analytical Chemistry, 85(19), 9229–9237.
MeSH headings : Ligands; Molecular Structure; Peptide Library; Peptides, Cyclic / analysis; Tandem Mass Spectrometry
TL;DR:
A method is shown for synthesis of the irreversible cyclic peptide corresponding to the proposed depsipeptide structure, to make the ligand stable to the aqueous acid and alkaline conditions encountered in affinity chromatographic applications.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Specificity and Regenerability of Short Peptide Ligands Supported on Polymer Layers for Immunoglobulin G Binding and Detection
ACS APPLIED MATERIALS & INTERFACES, 5(16), 8030–8037.
author keywords: short peptide ligands; immunoglobulin G detection; surface plasmon resonance; quartz crystal microgravimetry; regenerability; storage stability
MeSH headings : Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G / chemistry; Immunoglobulin G / isolation & purification; Ligands; Methacrylates / chemistry; Peptides / chemistry; Polyhydroxyethyl Methacrylate / chemistry; Polymers / chemistry; Protein Binding; Surface Plasmon Resonance
TL;DR:
Results from sodium dodecyl sulfate polyacrylamide gel electrophoresis and fluorescence microscopy indicate that the bioactive system is highly specific to IgG and resistant to nonspecific interactions when tested in mixed protein solutions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Affinity chromatographic purification of human immunoglobulin M from human B lymphocyte cell culture supernatant
BIOCHEMICAL ENGINEERING JOURNAL, 70, 63–70.
author keywords: Affinity chromatography; Hexamer peptide; Human immunoglobulin; IgM; Dynamic binding capacity; Elution additive
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Affinity chromatographic purification of human immunoglobulin a from chinese hamster ovary cell culture supernatant
BIOTECHNOLOGY PROGRESS, 29(1), 91–98.
author keywords: affinity chromatography; hexamer peptide; CHO; human immunoglobulin; secretory IgA
MeSH headings : Adsorption; Animals; CHO Cells; Cells, Cultured; Chromatography, Affinity; Cricetinae; Cricetulus; Humans; Immunoglobulin A / isolation & purification; Oligopeptides / chemical synthesis; Oligopeptides / chemistry; Surface Properties
TL;DR:
The peptide ligand resins exhibit great potential for large‐scale purification of both human IgA and secretory IgA, respectively, and the DBC value of HWRGWV for IgA is much greater than current commercially available affinity ligands.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Affinity membrane development from PBT nonwoven by photo-induced graft polymerization, hydrophilization and ligand attachment
JOURNAL OF MEMBRANE SCIENCE, 428, 562–575.
author keywords: Affinity membrane; Functional nonwoven fabrics; Surface modification; Protein purification; Nonspecific protein adsorption
TL;DR:
The DEG modified membrane was further developed by attachment of a specific proprietary ligand that binds to the prion protein, the agent responsible for transmissible spongiform encephalopathies, and showed good selectivity for the capture of prionprotein from hamster brain homogenate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Alkaline-stable peptide ligand affinity adsorbents for the purification of biomolecules
Journal of Chromatography A, 1245, 55–64.
author keywords: Peptide ligand; Affinity adsorbent; NaOH stability; Modification of surface chemistry; Solid-phase peptide synthesis; Cleaning-in-place
MeSH headings : Adsorption; Alkalies / chemistry; Chromatography, Affinity / instrumentation; Chromatography, Affinity / methods; Immunoglobulin G / chemistry; Immunoglobulin G / isolation & purification; Ligands; Peptides / chemistry; Protein Binding
TL;DR:
It was found that the ligand leaching was caused by the coupling of a significant amount of peptide by alkaline-labile ester bonds, and the method presented has a broad application since it is valid for any peptide ligand identified for the purification of a biopharmaceutical target.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold
PLOS ONE, 7(11).
MeSH headings : Carrier Proteins / genetics; Carrier Proteins / metabolism; Epitopes / genetics; Escherichia coli / genetics; Escherichia coli / metabolism; Histidine / genetics; Histidine / metabolism; Humans; Hydrogen-Ion Concentration; Immunoglobulin Fc Fragments / genetics; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / genetics; Immunoglobulin G / metabolism; Mutagenesis; Sulfolobus solfataricus / genetics; Sulfolobus solfataricus / metabolism
TL;DR:
P pH sensitive hFc binders are attractive candidates for use in chromatography, to achieve elution of IgG under milder pH conditions, but further studies are needed to evaluate if the Sso7d mutants identified in this study are indeed useful as affinity ligands in Chromatography.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Peptide-based affinity adsorbents with high binding capacity for the purification of monoclonal antibodies
Industrial & Engineering Chemistry Research, 52(26), 8800–8811.
TL;DR:
The development of affinity resins based on hexapeptide ligand HWRGWV for recovering monoclonal antibodies from cell culture fluids and the reaction conditions of peptide coupling were optimized to maximize the binding capacity of the resulting adsorbents.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Process for purification of monoclonal antibody expressed in transgenic Lemna plant extract using dextran-coated charcoal and hexamer peptide affinity resin
Journal of Chromatography A, 1260, 61–66.
author keywords: Dextran-coated charcoal; Transgenic plants; Hexapeptide ligand; IgG purification; Monoclonal antibody; Phenolics; Lemna minor
MeSH headings : Antibodies, Monoclonal / isolation & purification; Antibodies, Monoclonal / metabolism; Araceae / chemistry; Araceae / metabolism; Charcoal / chemistry; Chromatography, Affinity / methods; Dextrans / chemistry; Humans; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Peptides / chemistry; Peptides / metabolism; Plant Extracts / chemistry; Plants, Genetically Modified / chemistry; Plants, Genetically Modified / metabolism; Protein Binding; Staphylococcal Protein A / chemistry; Staphylococcal Protein A / isolation & purification
TL;DR:
The development of a pretreatment and affinity separation process for the purification of a monoclonal antibody from transgenic Lemna plant extract and the performance of the hexamer peptide resin after the pretreatment step was found to be similar to that obtained with a commercial Protein A resin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Purification of human immunoglobulins A, G and M from Cohn fraction II/III by small peptide affinity chromatography
JOURNAL OF CHROMATOGRAPHY A, 1262, 169–179.
author keywords: Hexamer peptide; IVIG; Cohn fraction; Elution additive; PEG; Ammonium sulfate
MeSH headings : Ammonium Sulfate / chemistry; Arginine / chemistry; Blood Proteins / chemistry; Caprylates / chemistry; Chromatography, Affinity / methods; Ethylene Glycols / chemistry; Humans; Immunoglobulin Isotypes / blood; Immunoglobulin Isotypes / isolation & purification; Peptides / chemistry; Salts / chemistry
TL;DR:
Attempts to purify human IgG, IgA and IgM from Cohn fraction II/III using HWRGWV affinity peptide resin using pretreatment methods comparable to current chromatographic purification methods involving two chromatography steps when hIgG is isolated from plasma fractions are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Purification of polyclonal antibodies from Cohn fraction II + III, skim milk, and whey by affinity chromatography using a hexamer peptide ligand
Journal of Separation Science, 35(22), 3139–3148.
author keywords: Affinity chromatography; Immunoglobulin G; Milk; Peptide ligands; Plasma
MeSH headings : Animals; Antibodies / chemistry; Antibodies / isolation & purification; Blood Proteins / chemistry; Blood Proteins / isolation & purification; Cattle; Chromatography, Affinity / instrumentation; Chromatography, Affinity / methods; Humans; Ligands; Milk / chemistry; Milk Proteins / chemistry; Milk Proteins / isolation & purification; Peptides / chemistry; Whey Proteins
TL;DR:
HWRGWV, a peptide that binds specifically to the Fc fragment of human immunoglobulin G (IgG), was used for the purification of IgG from Cohn fraction II + III of human plasma and from bovine skim milk and whey.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: August 28, 2020
2012 journal article
Specific Binding of Immunoglobulin G with Bioactive Short Peptides Supported on Antifouling Copolymer Layers for Detection in Quartz Crystal Microgravimetry and Surface Plasmon Resonance
ANALYTICAL CHEMISTRY, 85(2), 1106–1113.
MeSH headings : Binding Sites; Biofouling / prevention & control; Humans; Immunoglobulin G / chemistry; Particle Size; Peptides / chemical synthesis; Peptides / chemistry; Polymers / chemistry; Quartz Crystal Microbalance Techniques; Surface Plasmon Resonance; Surface Properties
TL;DR:
The effect of copolymer molecular composition and analyte concentration was elucidated in order to design systems based on immobilized peptides for high signal-to-noise response and detection limits that meet the requirements for IgG biosensing in fluid matrixes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands
Biotechnology and Bioengineering, 110(3), 857–870.
author keywords: cyclic peptide; mRNA display; Fc binding; affinity ligand; library
MeSH headings : Humans; Immunoglobulin Fc Fragments / metabolism; Peptide Library; Peptides, Cyclic / chemistry; Peptides, Cyclic / genetics; Peptides, Cyclic / isolation & purification; Peptides, Cyclic / metabolism; Protein Binding; Protein Engineering / methods; RNA, Messenger / genetics; Solid-Phase Synthesis Techniques / methods
TL;DR:
The discovery, synthesis and characterization of novel cyclic peptide affinity ligands that bind the Fc portion of human Immunoglobulin G (IgG; hFc) are described and the approach can be extended to efficiently generate and evaluatecyclic peptides for other targets of interest.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2011 journal article
Effects of UV Exposure and Initiator Concentration on the Spatial Variation of Poly(glycidyl methacrylate) Grafts on Nonwoven Fabrics
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 50(10), 6115–6123.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Effects of peptide density and elution pH on affinity chromatographic purification of human immunoglobulins A and M
JOURNAL OF CHROMATOGRAPHY A, 1218(46), 8344–8352.
author keywords: Human immunoglobulin; IgG; IgA; IgM; Affinity chromatography; Binding site
MeSH headings : Amino Acid Sequence; Binding Sites; Chromatography, Affinity / instrumentation; Chromatography, Affinity / methods; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Immunoglobulin A / chemistry; Immunoglobulin A / isolation & purification; Immunoglobulin M / chemistry; Immunoglobulin M / isolation & purification; Immunosorbent Techniques; Molecular Sequence Data; Oligopeptides / chemistry; Protein Conformation; Sequence Alignment
TL;DR:
Although HYFKFD and HFRRHL exhibited their ability for isolation of human IgG, IgA and IgM from cMEM as well, HWRGWV is the best option among them for large-scale purification
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Modeling the thermodynamic and transport properties of decahydronaphthalene/propane mixtures: Phase equilibria, density, and viscosity
FLUID PHASE EQUILIBRIA, 305(1), 25–33.
author keywords: Phase equilibria; Modified Sanchez-Lacombe Equation of State; Decahydronaphthalene; Propane; density; Viscosity; Volume expansion; Viscosity reduction; Free volume model for viscosity
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Polystyrene/Decahydronaphthalene/Propane Phase Equilibria and Polymer Conformation Properties from Intrinsic Viscosities
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 49(15), 1093–1100.
author keywords: conformational analysis; decahydronaphthalene; intrinsic viscosity; miscibility; phase behavior; phase diagrams; phase separation; polystyrene; viscosity
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Porcine parvovirus removal using trimer and biased hexamer peptides
Biotechnology Journal, 7(4), 558–565.
author keywords: Affinity adsorption; Biosafety; Bioseparation; Ligand; Virus removal
MeSH headings : Adsorption; Chromatography, Affinity; Humans; Parvovirus, Porcine / chemistry; Parvovirus, Porcine / isolation & purification; Peptides / chemical synthesis; Peptides / chemistry; Plasma / chemistry; Plasma / virology
TL;DR:
This study demonstrates that trimeric and hexameric peptides may have different, matrix‐specific roles to play in virus removal applications, and in general, the hexamer ligand may perform better for binding of specific viruses, whereas the trimer ligand might have more broadly reactive virus‐binding properties.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2010 journal article
Binding site on human immunoglobulin G for the affinity ligand HWRGWV
Journal of Molecular Recognition, n/a-n/a.
author keywords: hexamer ligand; immunoglobulin G; glycosylation; mass spectrometry; computational docking; binding site
MeSH headings : Amino Acid Sequence; Animals; Binding Sites; Endopeptidases / metabolism; Humans; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / chemistry; Immunoglobulin G / metabolism; Ligands; Models, Molecular; Molecular Sequence Data; Nerve Tissue Proteins / metabolism; Oligopeptides / chemistry; Oligopeptides / genetics; Oligopeptides / metabolism; Pepsin A / metabolism; Protein Binding; Protein Structure, Tertiary; Sequence Alignment; Staphylococcal Protein A / metabolism
TL;DR:
The results support the fact that a peptide as small as a hexamer can have specific interactions with large proteins such as hIgG and the HWRGWV ligand.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: February 24, 2020
2010 journal article
Binding site on human immunoglobulin G for the affinity ligand HWRGWV
Journal of Molecular Recognition, 23(3), 271–282.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Deposition of palladium catalyzed copper films by the displacement of two immiscible supercritical phases and subsequent reaction
JOURNAL OF MATERIALS CHEMISTRY, 20(19), 3973–3978.
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media
Journal of Chromatography A, 1218(13), 1691–1700.
author keywords: Hexapeptide ligand; IgG purification; Monoclonal antibody; Affinity chromatography; Regeneration
MeSH headings : Adsorption; Animals; Antibodies, Monoclonal / chemistry; Antibodies, Monoclonal / isolation & purification; CHO Cells; Caprylates; Cell Culture Techniques; Chromatography, Affinity / methods; Cricetinae; Cricetulus; Culture Media; Electrophoresis, Polyacrylamide Gel; Humans; Immunoglobulin G / chemistry; Immunoglobulin G / isolation & purification; Oligopeptides / chemistry; Phosphoric Acids; Protein Binding; Sodium Chloride; Urea
TL;DR:
Issues related to the successful application of the hexapeptide ligands, on a commercial methacrylate chromatographic resin, for the purification of IgG from mammalian cell culture fluids are addressed.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Polypropylene nonwoven fabrics with conformal grafting of poly(glycidyl methacrylate) for bioseparations
JOURNAL OF MEMBRANE SCIENCE, 364(1-2), 362–371.
author keywords: Conformal grafting; Polypropylene nonwoven; Glycidyl methacrylate; UV; Permeability coefficient
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Transport and Binding Characterization of a Novel Hybrid Particle Impregnated Membrane Material for Bioseparations
BIOTECHNOLOGY PROGRESS, 27(1), 129–139.
author keywords: particle-impregnated membrane; process integration; mathematical modeling
MeSH headings : Adsorption; Chromatography / instrumentation; Membranes, Artificial; Microscopy, Electron, Scanning; Models, Theoretical; Thermodynamics
TL;DR:
The results suggest that PIM constructs can be designed to process viscous mobile phases containing particulates while retaining the desirable binding characteristics of the embedded chromatographic resin and could find uses in adsorption separation processes from complex feed streams such as whole blood, cell culture, and food processing.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Ultrathin Cross-Linked Perfluoropolyether Film Coatings from Liquid CO2 and Subsequent UV Curing
CHEMISTRY OF MATERIALS, 22(8), 2411–2413.
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Deposition of Copper Particles and Films by the Displacement of Two Immiscible Supercritical Phases and Subsequent Reaction
Chemistry of Materials, 21(5), 913–924.
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2009 journal article
Determination of polystyrene-carbon dioxide-decahydronaphthalene solution properties by high pressure dynamic light scattering
POLYMER, 50(24), 5728–5732.
author keywords: Polystyrene; Diffusion; Dynamic light scattering
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Drug Delivery Technologies: The Way Forward in the New Decade
Industrial & Engineering Chemistry Research, 48(5), 2475–2486.
TL;DR:
The design and development of drug delivery systems involves many different sciences that underpin the research and significant advances will only be made through multidisciplinary teams that utilize the latest advances in the biological, chemical, physical, and engineering sciences.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2009 journal article
Influence of Peptide Ligand Surface Density and Ethylene Oxide Spacer Arm on the Capture of Porcine Parvovirus
BIOTECHNOLOGY PROGRESS, 25(5), 1411–1418.
author keywords: viral clearance; affinity resins; parvovirus; affinity ligands; combinatorial libraries
MeSH headings : Adsorption; Cells, Cultured; Chromatography, Affinity / methods; Ethylene Oxide / chemistry; Humans; Ligands; Particle Size; Parvovirus, Porcine / isolation & purification; Peptides / chemistry; Plasma / chemistry; Surface Properties
TL;DR:
Results indicate that low peptide densities enhance binding selectivity, facilitating specific peptide‐virus binding even in the presence of plasma proteins which can theoretically bind nonspecifically.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Mechanism of Extreme Ultraviolet Photoresist Development with a Supercritical CO2 Compatible Salt
LANGMUIR, 25(11), 6176–6190.
TL;DR:
The mechanism of developing an extreme ultraviolet (EUV) commercial photoresist with supercritical carbon dioxide (scCO2) and a CO2 compatible salt (CCS) solution was studied and the CCS partitioning into the resist was found to decrease with increasing temperature, revealing an enthalpy-driven CCS absorption.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Modeling Sorption Kinetics of Carbon Dioxide in Glassy Polymeric Films Using the Nonequilibrium Thermodynamics Approach
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 48(8), 3844–3854.
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Sorption of CO2 and a CO2 Compatible Salt into an Extreme Ultraviolet Photoresist Film on a SiO2 Substrate
JOURNAL OF PHYSICAL CHEMISTRY B, 113(29), 9687–9693.
MeSH headings : Adsorption; Carbon Dioxide / chemistry; Diffusion; Membranes, Artificial; Pressure; Salts / chemistry; Silicon Dioxide / chemistry; Solutions; Surface Properties; Temperature; Ultraviolet Rays
TL;DR:
The sorption behavior of CO2 and the CCS onto a bare SiO2 surface and into the photoresist was studied using a quartz crystal microbalance (QCM) and the adsorption of the C CS was favored and driven by entropy changes.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2008 article
Identification of trimeric peptides that bind porcine parvovirus from mixtures containing human blood plasma
BIOTECHNOLOGY PROGRESS, Vol. 24, pp. 554–560.
MeSH headings : Animals; Complex Mixtures / isolation & purification; Complex Mixtures / metabolism; Humans; Oligopeptides / metabolism; Parvovirus, Porcine / isolation & purification; Parvovirus, Porcine / metabolism; Plasma / metabolism; Plasma / virology
TL;DR:
The results of this work indicate that small peptide ligand resins have the potential to be used in virus removal processes where removal of contaminating virus is necessary to ensure product safety.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 patent
Prion protein binding materials and methods of use
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2008 journal article
Purification of human immunoglobulin G via Fc-specific small peptide ligand affinity chromatography
JOURNAL OF CHROMATOGRAPHY A, 1216(6), 910–918.
author keywords: Human immunoglobulin G; Fc fragment; Hexamer peptide ligand; Affinity chromatography; Ligand density
MeSH headings : Adsorption; Chromatography, Affinity / methods; Culture Media; Humans; Immobilized Proteins / chemistry; Immobilized Proteins / metabolism; Immunoglobulin Fc Fragments / metabolism; Immunoglobulin G / isolation & purification; Immunoglobulin G / metabolism; Kinetics; Ligands; Peptides / chemistry; Peptides / metabolism; Temperature
TL;DR:
The results indicate that these small peptide ligands, especially HWRGWV, offer a potential alternative to the use of Protein A or Protein G for large scale affinity chromatography.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 article
Three-component phase behavior of the sclareol-ethyl lactate-carbon dioxide system for GAS applications
Tombokan, X. C., Aguda, R. M., Danehower, D. A., Kilpatrick, P. K., & Carbonell, R. G. (2008, June). JOURNAL OF SUPERCRITICAL FLUIDS, Vol. 45, pp. 146–155.
author keywords: GAS; GRAS solvents; nutraceuticals; sclareol; extraction; precipitation
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Deposition of poly[2-(perfluorooctyl)ethyl acrylate] from liquid CO2 high-pressure free meniscus coating—Uniformity and morphology
The Journal of Supercritical Fluids, 42(1), 129–141.
author keywords: liquid carbon dioxide; free meniscus coating; poly [2-(perfluorooctyl)ethyl acrylate]; thin fluorinated film
Source: Crossref
Added: August 28, 2020
2007 journal article
Deposition of poly[2-(perfluorooctyl)ethyl acrylate] on silicon wafers by the displacement of two immiscible supercritical phases (DISP)
JOURNAL OF SUPERCRITICAL FLUIDS, 43(1), 139–149.
author keywords: supercritical carbon dioxide; supercritical helium; immiscibility; coating; poly[2-(perfluorooctyl)ethyl acrylate]; thin fluorinated film
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Determination of the liquid pool surfactant and protein concentration for semi-batch foam fractionation columns
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING, 24(1), 1–14.
author keywords: foam fractionation; proteins; surfactant; bubble column
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Hydrothermal oxidation treatment of solid particles between 250 and 350 degrees C: Modelling and experiments
JOURNAL OF SUPERCRITICAL FLUIDS, 41(3), 352–360.
author keywords: hydrothermal oxidation; modelling; reactor; experimental device; solid particles; particle size distribution
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Surface properties of poly[2-(perfluorooctyl)ethyl acrylate] deposited from liquid CO2 high-pressure free meniscus coating
MACROMOLECULES, 40(3), 588–597.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2006 journal article
A colorimetric assay for viral agents that produce cytopathic effects
Journal of Virological Methods, 135(1), 56–65.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
A colorimetric assay for viral agents that produce cytopathic effects
Journal of Virological Methods, 135(1), 56–65.
author keywords: MTT; TCID50; plaque assay; parvovirus; Sindbis virus
MeSH headings : Animals; Cell Line; Colorimetry / methods; Cricetinae; Cytopathogenic Effect, Viral; Dogs; Formazans / metabolism; Humans; Minute Virus of Mice / pathogenicity; Parvovirus, Canine / pathogenicity; Parvovirus, Porcine / pathogenicity; Reproducibility of Results; Sindbis Virus / pathogenicity; Swine; Tetrazolium Salts / metabolism; Viral Plaque Assay; Viruses / pathogenicity
TL;DR:
MTT has been applied to measure cytopathic effect produced by viral infection for different members of the parvovirus family and an unrelated virus, Sindbis, which is routinely titrated by plaque assay.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: August 28, 2020
2006 journal article
Alicyclic photoresists for CO2-based next-generation microlithography: A tribute to James E. McGrath
POLYMER, 47(11), 4012–4017.
author keywords: condensed CO2; addition polymerization; photoresist synthesis
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Deposition of small organic molecules by the displacement of two immiscible supercritical phases
LANGMUIR, 22(5), 2117–2129.
TL;DR:
Estimates of characteristic times for diffusion and nucleation indicate that DISP is a diffusion-limited process, and films deposited from scCO2 by DISP were much thicker, more uniform, and exhibited much fewer drying defects and lower RMS roughness compared with films from the organic solvents.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Design of Adsorptive Columns for Specific Pathogen Removal: Application to Staphylococcal Enterotoxin B
Biotechnology Progress, 22(5), 1358–1367.
MeSH headings : Adsorption; Bacterial Toxins / isolation & purification; Bacterial Toxins / metabolism; Biochemistry / methods; Biological Products / standards; Biological Products / therapeutic use; Biotechnology / methods; Blood Proteins / isolation & purification; Blood Proteins / standards; Decontamination / methods; Disinfection / methods; Dose-Response Relationship, Drug; Enterotoxins / chemistry; Enterotoxins / metabolism; Enzyme-Linked Immunosorbent Assay; Kinetics; Models, Statistical; Peptides / chemistry; Toxins, Biological / chemistry
TL;DR:
The theory, with no adjustable parameters, is shown to predict with great accuracy the effect of residence time on the log removal of staphylococcal enterotoxin B from solution using an affinity resin with a small peptide that has been found to bind specifically to this toxin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Crossref
Added: January 14, 2021
2006 journal article
Design of adsorptive columns for specific pathogen removal: Application to staphylococcal enterotoxin B
Biotechnology Progress, 22(5), 1358–1367.
Source: NC State University Libraries
Added: August 6, 2018
2006 journal article
Reduction in infectivity of endogenous transmissible spongiform encephalopathies present in blood by adsorption to selective affinity resins
LANCET, 368(9554), 2226–2230.
MeSH headings : Adsorption; Animals; Cricetinae; Filtration / methods; Prion Diseases / prevention & control; Prion Diseases / transmission; Prions / blood; Prions / isolation & purification; Prions / pathogenicity; Transfusion Reaction
TL;DR:
Results showed removal of endogenous TSE infectivity from leucoreduced whole blood by affinity ligands, which can be used to mitigate the risks from TSE-infected blood, blood products, and other materials exposed to TSEinfectivity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Reduction of transmissible spongiform encephalopathy infectivity from human red blood cells with prion protein affinity ligands
TRANSFUSION, 46(7), 1152–1161.
MeSH headings : Animals; Combinatorial Chemistry Techniques; Cricetinae; Erythrocyte Transfusion / methods; Erythrocyte Transfusion / standards; Erythrocytes / chemistry; Humans; Ligands; Models, Biological; Prion Diseases / prevention & control; Prions / blood; Prions / isolation & purification; Protein Binding; Titrimetry
TL;DR:
Blood‐borne TSE infectivity cannot be detected with a diagnostic test, nor is it likely to be amenable to inactivation; however, its depletion with specific adsorp‐tive ligand resins is possible.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2006 journal article
Studies on CO2-based slurries and fluorinated silica and alumina particles for chemical mechanical polishing of copper films
JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 153(12), G1064–G1071.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Characterization of a peptide affinity support that binds selectively to staphylococcal enterotoxin B
JOURNAL OF CHROMATOGRAPHY A, 1078(1-2), 98–112.
author keywords: mathematical modeling; peptide affinity chromatography; peptide density; staphylococcal enterotoxin B
MeSH headings : Adsorption; Chromatography, Affinity / instrumentation; Chromatography, Affinity / methods; Diffusion; Enterotoxins / chemistry; Enterotoxins / isolation & purification; Kinetics; Ligands; Models, Chemical; Oligopeptides / chemistry
TL;DR:
An analysis of the number of transfer units for the various mass transfer steps in the column indicated that film mass transfer, pore diffusion and the kinetics of adsorption can all play an important role in the overall rate of Adsorption.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Characterization of microcellular biodegradable polymeric foams produced from supercritical carbon dioxide solutions
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 44(6), 1795–1803.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Chemical functionalization of silica and alumina particles for dispersion in carbon dioxide
LANGMUIR, 21(11), 4816–4823.
TL;DR:
The steric stabilization and flocculation of modified silica and alumina particle suspensions in condensed CO(2) were studied and the C(8)F(17)COOH-alumina particles gave a significantly higher graft density but are not as stable inCO(2).
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Hexamer peptide affinity resins that bind the Fc region of human immunoglobulin G
JOURNAL OF PEPTIDE RESEARCH, 66, 120–137.
author keywords: affinity chromatography; Fc fragment; hexapeptide; immunoglobulin
TL;DR:
It was found that HWRGWV possessed the potential to purify HIgG from complete mammalian cell culture medium containing 10% fetal calf serum with purity comparable to commercially available resins, but using milder elution conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Hydrogenation of polystyrene in CO2-expanded solvents: Catalyst poisoning
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 44(16), 6164–6170.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Nonequilibrium model for sorption and swelling of bulk glassy polymer films with Supercritical carbon dioxide
MACROMOLECULES, 38(24), 10299–10313.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2005 article
Small Peptide Ligands for Affinity Separations of Biological Molecules
CHEMICAL ENGINEERING TRENDS AND DEVELOPMENTS, pp. 63–83.
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Ultrathin film deposition by liquid CO2 free meniscus coating-uniformity and morphology
LANGMUIR, 22(2), 642–657.
MeSH headings : Carbon Dioxide / chemistry; Coated Materials, Biocompatible / chemistry; Freezing; Materials Testing; Microscopy, Atomic Force; Silicon / chemistry; Solvents / chemistry; Sucrose / analogs & derivatives; Sucrose / chemistry; Surface Properties
TL;DR:
The film thickness and morphology of SOA films deposited from 1-CO2 hFMC were compared to those deposited from toluene and acetone under normal dip coating and were much thinner, more uniform, and exhibited much fewer drying defects and lower RMS roughness.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
"dry" lithography using liquid and supercritical carbon dioxide based chemistries and processes
IEEE TRANSACTIONS ON SEMICONDUCTOR MANUFACTURING, 17(4), 510–516.
author keywords: liquid and supercritical carbon dioxide; lithography; photoacid generator; photoresist; resist contrast; resist sensitivity
UN Sustainable Development Goal Categories
9. Industry, Innovation and Infrastructure
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2004 journal article
A hexamer peptide ligand that binds selectively to staphylococcal enterotoxin B: isolation from a solid phase combinatorial library
JOURNAL OF PEPTIDE RESEARCH, 64(2), 51–64.
author keywords: affinity adsorption; combinatorial peptide library; peptide ligands; staphylococcal enterotoxin B
MeSH headings : Amino Acid Sequence; Enterotoxins / metabolism; Humans; Ligands; Peptide Library; Peptides / chemistry; Peptides / metabolism; Protein Binding; Staphylococcus aureus / metabolism; Superantigens / metabolism
TL;DR:
By screening a solid-phase combinatorial peptide library, a short peptide ligand, YYWLHH, has been discovered that binds with high affinity and selectivity to staphylococcal enterotoxin B, but only weakly to other SEs that share sequence and structural homology with SEB.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2004 review
Applications of "dry" processing in the microelectronics industry using carbon dioxide
[Review of ]. CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SCIENCES, 29(3-4), 97–109.
author keywords: supercritical fluids; semiconductors; cleaning; etching; phoioresist; stripping.; drving; low-k; metal deposition.
Source: Web Of Science
Added: August 6, 2018
2004 patent
CO2-processes photoresists, polymers, and photoactive compounds for microlithography
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2004 patent
Carbon dioxide-soluble polymers and swellable polymers for carbon dioxide applications
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Phase equilibrium for the hydrogenation of polystyrene in CO2–swollen solvents
The Journal of Supercritical Fluids, 34(1), 1–9.
author keywords: hydrogenation; polystyrene; supercritical carbon dioxide; phase equilibrium; Peng-Robinson
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Crossref
Added: August 28, 2020
2004 journal article
Spin coating of photoresists using liquid carbon dioxide
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 43(9), 2113–2122.
Source: Web Of Science
Added: August 6, 2018
2003 journal article
A novel process for demulsification of water-in-crude oil emulsions by dense carbon dioxide
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 42(25), 6661–6672.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 patent
Apparatus for meniscus coating with liquid carbon dioxide
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Deposition of Thin Polymeric Films from Liquid Carbon Dioxide Using a High-Pressure Free-Meniscus Coating Process
Industrial & Engineering Chemistry Research, 43(2), 515–524.
Sources: Web Of Science, Crossref
Added: August 6, 2018
2003 journal article
Kinetic and transport processes in the heterogeneous catalytic hydrogenation of polystyrene
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 42(15), 3509–3515.
UN Sustainable Development Goal Categories
12. Responsible Consumption and Production
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
Kinetics of nonequilibrium nanocrystal monolayer formation: Deposition from liquid carbon dioxide
NANO LETTERS, 3(12), 1671–1675.
Source: Web Of Science
Added: August 6, 2018
2003 patent
Method for meniscuscoating a substrate with a polymeric precurso
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2003 patent
Methods of demulsifying emulsions using carbon dioxide
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2003 journal article
Phase equilibrium behavior of the binary systems CO2 plus nonadecane and CO2 plus soysolv and the ternary system CO2 plus soysolv plus quaternary ammonium chloride surfactant
JOURNAL OF CHEMICAL AND ENGINEERING DATA, 48(6), 1401–1406.
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Effect of polymer coatings from CO2 on water-vapor transport in porous media
AICHE JOURNAL, 48(5), 941–952.
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Formation of self-assembled monolayers of semifluorinated and hydrocarbon chlorosilane precursors on silica surfaces from liquid carbon dioxide
LANGMUIR, 18(16), 6170–6179.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2002 journal article
Hydrodynamics of trickling flow in packed beds: Relative permeability concept
AICHE JOURNAL, 48(4), 731–738.
UN Sustainable Development Goal Categories
1. No Poverty
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 patent
Spin cleaning methods
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Affinity purification of fibrinogen using a ligand from a peptide library
BIOTECHNOLOGY AND BIOENGINEERING, 77(3), 278–289.
author keywords: fibrinogen; peptide affinity chromatography; protein purification
MeSH headings : Adsorption; Chromatography, Affinity / methods; Fibrinogen / isolation & purification; Fibrinogen / metabolism; Humans; Hydrogen-Ion Concentration; Peptide Library; Peptides / chemical synthesis; Peptides / metabolism; Salts; Temperature
TL;DR:
The effective association constant of fibrinogen was substantially higher when the peptide was immobilized on the resin than in solution; moreover, it increased with increasing peptide density, suggesting a cooperative binding effect.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 patent
Apparatus for liquid carbon dioxide systems
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2001 patent
Enzyme catalysis in carbon dioxide fluids
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Formation of perfluoropolyether coatings by the rapid expansion of supercritical solutions (RESS) process. Part 1: Experimental results
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 40(26), 6118–6126.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
Formation of perfluoropolyether coatings by the rapid expansion of supercritical solutions (RESS) process. Part 2: Numerical modeling
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 40(26), 6127–6139.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
Identification of peptide ligands generated by combinatorial chemistry that bind alpha-lactalbumin
SEPARATION SCIENCE AND TECHNOLOGY, 36(11), 2411–2431.
TL;DR:
The identification of the hexapeptide WHWRKR, obtained from a combinatorial library, that shows affinity for α-lactalbumin is described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2001 patent
Methods of spin cleaning substrates using carbon dioxide liquid
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Processing of polyamide 11 with supercritical carbon dioxide
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 40(23), 5570–5577.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2001 journal article
Studies of the binding of alpha-lactalbumin to immobilized peptide ligands
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 49(12), 5765–5770.
author keywords: alpha-lactalbumin; peptide ligands; bioselective adsorption; binding mechanism
MeSH headings : Adsorption; Amino Acid Sequence; Lactalbumin / metabolism; Ligands; Mutagenesis, Site-Directed; Oligopeptides / metabolism; Protein Binding; Protein Precursors / metabolism; Recombinant Proteins / metabolism; Resins, Plant; Thermodynamics
TL;DR:
The present work investigates the mechanism of binding of α-lactalbumin to the peptide ligand WH WRKR and its variants HWRKR and acetylated WHWRKR immobilized on a polymethacrylate chromatographic resin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Chromatographic resolution of tryptophan enantiomers with L-Leu-L-Leu-L-Leu peptide - Effects of mobile phase composition and chromatographic support
JOURNAL OF CHROMATOGRAPHY A, 874(1), 21–26.
author keywords: enantiomer separation; mobile phase composition; stationary phases, LC; amino acids; tryptophan
MeSH headings : Chromatography, High Pressure Liquid / methods; Oligopeptides / chemistry; Stereoisomerism; Tryptophan / chemistry; Tryptophan / isolation & purification
TL;DR:
Results indicate that binding is significantly reduced and separation is not achieved when Leu-Leu- Leu is coupled onto cross-linked or polymerized hydrophilic resins as well as onto macroporous polystyrene resin, which suggests the Leu/LeuLeu structure is critical for enantiomer resolution.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Discovery of alpha-1-proteinase inhibitor binding peptides from the screening of a solid phase combinatorial peptide library
SEPARATION SCIENCE AND TECHNOLOGY, 35(11), 1681–1706.
author keywords: protein purification; alpha-1-proteinase inhibitor; combinatorial peptide library; affinity chromatography
TL;DR:
Alpha-1-proteinase inhibitor (A1PI), a blood plasma protein, was radiolabeled and screened against a portion of a hexameric, solid-phase combinatorial peptide library, which yielded 19 sequences with varying avidities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Fractionation of whey proteins with a hexapeptide ligand affinity resin
BIOSEPARATION, 9(6), 385–392.
author keywords: alpha-lactalbumin; bioselective adsorption; peptide ligands; whey protein isolate
MeSH headings : Animals; Cattle; Chromatography, Affinity / methods; Lactalbumin / isolation & purification; Ligands; Milk Proteins / isolation & purification; Oligopeptides; Resins, Synthetic; Whey Proteins
TL;DR:
This study describes two methods for production of α-lactalbumin from whey protein isolate using bioselective adsorption and the combined use of an amino resin followed by the WHWRKR resin produce a highly purified α- lact Albumin (100%).
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Gas-lift reactors for rapid reactions with appreciable gas consumption
Chemical Engineering & Technology, 23(1), 80–87.
TL;DR:
Several one-dimensional models have been developed to describe kinetic/hydrodynamic coupling in gas-lift reactors and offer useful insights into the parameters that affect reactor performance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2000 patent
Method and compositions for protecting civil infrastructure
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2000 patent
Method for meniscus coating with liquid carbon
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2000 patent
Method for meniscus coating with liquid carbon dioxide
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Multiphase flow models in packed beds
OIL & GAS SCIENCE AND TECHNOLOGY-REVUE D IFP ENERGIES NOUVELLES, 55(4), 417–425.
author keywords: drag force; permeability; pressure drop; holdup; flow transition; hydrodynamic regime
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Recovery of proteins and other biological compounds from food processing wastewaters using fibrous materials and polyelectrolytes
WATER RESEARCH, 34(2), 510–518.
author keywords: food processing; wastewaters; protein; fibrous materials; polyelectrolytes; adsorption; filtration; animal feed
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Removal of solid organic films from rotating disks using emulsion cleaners
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 228(2), 344–358.
author keywords: emulsion; cleaning; phenanthrene; solubilization; rotating disk
TL;DR:
Measurements have been made of the rate of removal of a solid organic film (phenanthrene) from the surface of a rotating disk using emulsions containing water, the nonionic surfactant Tween 20, and d-limonene as the organic phase to show that phenanthrene removal initially occurs by the uptake of Phenanthrene into the emulsion drops as small aggregates.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 journal article
Affinity chromatographic screening of soluble combinatorial peptide libraries
BIOTECHNOLOGY AND BIOENGINEERING, 63(6), 633–641.
author keywords: affinity chromatography; affinity ligand; combinatorial libraries; peptide; soluble peptide library
TL;DR:
The screened peptide libraries resulted in affinity peptides with the sequences GVNFEVVG, GVNFTVVG and GVFFEL(I)VG, which contained the clear consensus sequence NFEV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Coupling of hydrodynamics and chemical reaction in gas-lift reactors
AIChE Journal, 45(2), 410–423.
Source: NC State University Libraries
Added: August 6, 2018
1999 article
Hydrodynamics of gas-lift reactors with a fast, liquid-phase reaction
Marquez, M. A., Amend, R. J., Carbonell, R. G., Saez, A. E., & Roberts, G. W. (1999, July). CHEMICAL ENGINEERING SCIENCE, Vol. 54, pp. 2263–2271.
author keywords: carbon dioxide; gas-lift reactor; hydrodynamics; mass transfer; modeling; potassium hydroxide
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 article
Peptide affinity chromatography process for adsorption of fibrinogen
Lucena, S. L., Carbonell, R. G., & Santana, C. C. (1999, February). POWDER TECHNOLOGY, Vol. 101, pp. 173–177.
author keywords: affinity chromatography; peptide libraries; proteins; adsorption; fibrinogen
TL;DR:
A way to obtain parameters such as the adsorption rate constants, by fitting the breakthrough curves, is presented.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Preparation and characterization of liposomal systems entrapping the boronated compound o-carboranylpropylamine
Journal of Microencapsulation, 16(5), 647–664.
MeSH headings : Boron Compounds / chemistry; Boron Compounds / pharmacokinetics; Boron Compounds / toxicity; Boron Neutron Capture Therapy; Cell Adhesion; Detergents / chemistry; Drug Stability; Drug Storage; Glioblastoma / drug therapy; Glioblastoma / metabolism; Glioblastoma / pathology; Humans; Hydrogen-Ion Concentration; Isotopes; Liposomes; Lymphocytes / drug effects; Phosphatidylcholines / chemistry; Phosphatidylcholines / metabolism; Phosphatidylethanolamines / chemistry; Phosphatidylethanolamines / metabolism; Polyethylene Glycols / chemistry; Polyethylene Glycols / metabolism; Tumor Cells, Cultured
TL;DR:
Results demonstrate that CPA loading and vesicle stability can be controlled by the experimental procedure and CPA toxicity to normal human peripheral blood lymphocytes and to adherent glioblastoma multiforme SK-MG-1 cells in vitro is observed to decrease as a result of the entrapment of CPA in liposomes.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Recovery of proteins and other biological compounds using fibrous materials: I. Adsorption by salt addition
Journal of Chemical Technology and Biotechnology, 74(8), 733–739.
TL;DR:
An adsorption and filtration process for the recovery of proteins and other biological compounds from aqueous streams has been developed, using cellulose-based fibrous materials, with high protein recovery obtained from an actual wastewater system at low salt dosages.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Recovery of proteins and other biological compounds using fibrous materials: II. Flocculation by polyelectrolyte addition
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 74(8), 740–750.
author keywords: protein recovery; wastewater treatment; animal feed; flocculation; polyelectrolytes; fibrous materials; cellulose acetate; triacetate; fibrets
TL;DR:
An adsorption and filtration process for the recovery of valuable biological compounds using cellulose-based fibrous materials has been developed and resulted in high recovery of biomolecules from solution at very low dosages of both polyelectrolyte and fibrets.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Removal rates of major and trace components of an organic film using aqueous nonionic surfactant solutions
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 38(3), 683–691.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1999 patent
Spin coating method and apparatus for liquid carbon dioxide systems
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Supercritical CO2 as a solvent for polymeric stone protective materials
JOURNAL OF SUPERCRITICAL FLUIDS, 15(2), 173–179.
author keywords: fluorinated polymers; new solvent; solubility measurement; stone protection; supercritical carbon dioxide
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Hydrodynamic model for gas-lift reactors
AICHE JOURNAL, 44(6), 1413–1423.
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Removal of organic films from rotating disks using aqueous solutions of nonionic surfactants: Effect of surfactant molecular structure
Journal of Colloid and Interface Science, 206(1), 102–111.
TL;DR:
It was found that for surfactants with relatively high solubilization rates, the shear-driven cleaning stage did not occur, and the selection of the most efficient surfactant depends on whether the Surfactant concentration is below or above its critical micelle concentration (CMC).
(via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
1998 journal article
Screening of combinatorial peptide libraries: Identification of ligands for affinity purification of proteins using a radiological approach
Journal of Peptide Research, 52(6), 526–536.
MeSH headings : Autoradiography / methods; Carbon Radioisotopes; Electrophoresis, Polyacrylamide Gel; Fibrinogen / chemistry; Humans; Ligands; Peptide Library; Radioisotopes; Resins, Plant / chemistry; Serum Albumin / chemistry
TL;DR:
A radiological screening method, using 14C as a radioactive label, that offers high resolution and sensitivity and less than 100 DPM/bead are detectable after a one-day exposure using autoradiography.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1997 patent
Methods of treating wastewater
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Selective precipitation of antibody with ligand-modified phospholipids: Effect of lipid chain length
BIOTECHNOLOGY PROGRESS, 13(4), 446–452.
TL;DR:
The molecular picture which emerges is one in which the optimal rate is obtained by maximizing hydrophobic driving force for interaction of LMP acyl chains while still maintaining a submicellar state of aggregation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
6. Clean Water and Sanitation
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Dynamic and equilibrium phase behavior in the C(12)E(5) abietic acid H2O system
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 182(2), 465–472.
author keywords: micelles; nonionic surfactants; surfactant phase behavior; detergency; solubilization
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1996 journal article
Removal of organic films from rotating disks using aqueous solutions of nonionic surfactants: Film morphology and cleaning mechanisms
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 35(12), 4494–4506.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 journal article
REMOVAL OF ORGANIC FILMS FROM SOLID-SURFACES USING AQUEOUS-SOLUTIONS OF NONIONIC SURFACTANTS .1. EXPERIMENTS
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 34(10), 3307–3317.
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1995 journal article
Removal of organic films from solid surfaces using aqueous solutions of nonionic surfactants. 2. Theory
Industrial & Engineering Chemistry Research, 34(10), 3318–3325.
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018
patent
Alpha-1 proteinase inhibitor binding peptides
Bastek, P. D., Lang, J. M., Baumbach, G. A., & Carbonell, R. G. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
patent
Chromatography apparatus
Carbonell, R. G., Kilpatrick, P. K., Torres, J. L., & Guzman, R. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
patent
Compositions for protecting civil infrastructure
Carbonell, R. G., DeSimone, J. M., & Henon, F. E. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
review
Drug delivery technologies: The way forward in the new decade
Valle, E. M. M., Galan, M. A., & Carbonell, R. G. [Review of ]. Industrial & Engineering Chemistry Research, 48(5), 2475–2486.
Source: NC State University Libraries
Added: August 6, 2018
patent
Hydrogenation of polymers in the presence of supercritical carbon dioxide
Roberts, G. W., Xu, D., Kiserow, D. J., & Carbonell, R. G. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
patent
Immunodiagnostic assay using liposomes carrying labels thereof on outer liposome surface
Carbonell, R. G., Kilpatrick, P. K., Jones, M. A., & Singh, A. K. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
patent
Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents
Carbonell, R. G., Kilpatrick, P., & Saki, N.
Source: NC State University Libraries
Added: August 6, 2018
patent
Methods of deresinating crude oils using carbon dioxide
Zaki, N. N., Kilpatrick, P. K., & Carbonell, R. G.
Source: NC State University Libraries
Added: August 6, 2018
patent
Peptide ligands for affinity purification of fibrinogen
Mondorf, K., Carbonell, R. C., & Buettner, J. A. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Phase equilibrium for the hydrogenation of polystyrene in CO2-swollen solvents
Xu, D. W., Carbonell, R. G., Roberts, G. W., & Kiserow, D. J. Journal of Supercritical Fluids, 34(1), 09-.
Source: NC State University Libraries
Added: August 6, 2018
patent
Precipitation of multivalent antiligands with affinity surfactants
Carbonell, R. G., Guzman, R., & Kilpatrick, P. K. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
patent
Precipitation of multivalent antiligands with affinity surfactants
Carbonell, R. G., Guzman, R., & Kilpatrick, P. K. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
journal article
Preface: Seventh International Symposium on Supercritical Fluids (ISSF2005)
Brennecke, J. F., Johnston, K. P., & Carbonell, R. G. Industrial & Engineering Chemistry Research, 45(10), 3327.
Source: NC State University Libraries
Added: August 6, 2018
patent
Prion protein binding materials and methods of use
Hammond, D. J., Carbonell, R. G., Shen, H., Gurgel, P. V., Wiltshire-Lyerly, V., & Burton, S. J.
Source: NC State University Libraries
Added: August 6, 2018
patent
Purification by affinity binding to liposomes
Kilpatrick, P. K., Carbonell, R. G., & Powers, J. D. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
patent
Purification of immunoglobulins using affinity chromatography and peptide ligands
Carbonell, R. G., Yang, H., & Gurgel, P. V. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
patent
Recombinant factor VIII binding peptides
Chen, C. L., Buettner, J. A., & Carbonell, R. G. Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
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