Ruben Carbonell Pham, D. N., Linova, M. Y., Smith, W. K., Brown, H., Elhanafi, D., Fan, J., … Carbonell, R. G. (2024). Novel multimodal cation-exchange membrane for the purification of a single-chain variable fragment from Pichia pastoris supernatant. JOURNAL OF CHROMATOGRAPHY A, 1718. https://doi.org/10.1016/j.chroma.2024.464682 Lavoie, J., Fan, J., Pourdeyhimi, B., Boi, C., & Carbonell, R. G. (2023, May 31). Advances in high-throughput, high-capacity nonwoven membranes for chromatography in downstream processing: A review. BIOTECHNOLOGY AND BIOENGINEERING, Vol. 5. https://doi.org/10.1002/bit.28457 Kilgore, R., Chu, W., Bhandari, D., Fischler, D., Carbonell, R. G., Crapanzano, M., & Menegatti, S. (2023). Development of peptide affinity ligands for the purification of polyclonal and monoclonal Fabs from recombinant fluids. JOURNAL OF CHROMATOGRAPHY A, 1687. https://doi.org/10.1016/j.chroma.2022.463701 Mukherjee, R. P., Yow, G.-Y., Sarakbi, S., Menegatti, S., V. Gurgel, P., Carbonell, R. G., & Bobay, B. G. (2023). Integrated in silico and experimental discovery of trimeric peptide ligands targeting Butyrylcholinesterase. COMPUTATIONAL BIOLOGY AND CHEMISTRY, 102. https://doi.org/10.1016/j.compbiolchem.2022.107797 Fan, J., Sripada, S. A., Pham, D. N., Linova, M. Y., Woodley, J. M., Menegatti, S., … Carbonell, R. G. (2023). Purification of a monoclonal antibody using a novel high-capacity multimodal cation exchange nonwoven membrane. SEPARATION AND PURIFICATION TECHNOLOGY, 317. https://doi.org/10.1016/j.seppur.2023.123920 Boi, C., Malavasi, A., Carbonell, R. G., & Gilleskie, G. (2022, March 15). A direct comparison between membrane adsorber and packed column chromatography performance (vol 1612, 460629, 2020). JOURNAL OF CHROMATOGRAPHY A, Vol. 1666. https://doi.org/10.1016/j.chroma.2022.462852 Fan, J., Barbieri, E., Shastry, S., Menegatti, S., Boi, C., & Carbonell, R. G. (2022). Purification of Adeno-Associated Virus (AAV) Serotype 2 from Spodoptera frugiperda (Sf9) Lysate by Chromatographic Nonwoven Membranes. MEMBRANES, 12(10). https://doi.org/10.3390/membranes12100944 Sripada, S. A., Chu, W., Williams, T. I., Teten, M. A., Mosley, B. J., Carbonell, R. G., … Menegatti, S. (2022, April 22). Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents. BIOTECHNOLOGY AND BIOENGINEERING, Vol. 119. https://doi.org/10.1002/bit.28096 Lavoie, R. A., Islam, T., Blackburn, W. R. K., Carbonell, R. G., & Menegatti, S. (2021). Development of Peptide Ligands for Targeted Capture of Host Cell Proteins from Cell Culture Production Harvests. PROTEOMIC PROFILING, 2 EDITION, Vol. 2261, pp. 489–506. https://doi.org/10.1007/978-1-0716-1186-9_31 Fan, J., Boi, C., Lemma, S. M., Lavoie, J., & Carbonell, R. G. (2021). Iminodiacetic Acid (IDA) Cation-Exchange Nonwoven Membranes for Efficient Capture of Antibodies and Antibody Fragments. MEMBRANES, 11(7). https://doi.org/10.3390/membranes11070530 Lemma, S. M. I., Boi, C., & Carbonell, R. G. (2021). Nonwoven Ion-Exchange Membranes with High Protein Binding Capacity for Bioseparations. MEMBRANES, 11(3). https://doi.org/10.3390/membranes11030181 Lavoie, R. A., Chu, W., Lavoie, J. H., Hetzler, Z., Williams, T. I., Carbonell, R., & Menegatti, S. (2021). Removal of host cell proteins from cell culture fluids by weak partitioning chromatography using peptide-based adsorbents. SEPARATION AND PURIFICATION TECHNOLOGY, 257. https://doi.org/10.1016/j.seppur.2020.117890 Boi, C., Malavasi, A., Carbonell, R. G., & Gilleskie, G. (2020). A direct comparison between membrane adsorber and packed column chromatography performance. JOURNAL OF CHROMATOGRAPHY A, 1612. https://doi.org/10.1016/j.chroma.2019.460629 Reese, H. R., Xiao, X., Shanahan, C. C., Driessche, G. A., Fourches, D., Carbonell, R. G., … Menegatti, S. (2020). Novel peptide ligands for antibody purification provide superior clearance of host cell protein impurities. JOURNAL OF CHROMATOGRAPHY A, 1625. https://doi.org/10.1016/j.chroma.2020.461237 Lavoie, R. A., Fazio, A., Williams, T. I., Carbonell, R., & Menegatti, S. (2020). Targeted capture of Chinese hamster ovary host cell proteins: Peptide ligand binding by proteomic analysis. BIOTECHNOLOGY AND BIOENGINEERING, 117(2), 438–452. https://doi.org/10.1002/bit.27213 Lavoie, R. A., Fazio, A., Carbonell, R. G., & Menegatti, S. (2019). Multiplexed Competitive Screening of One-Bead-One-Component Combinatorial Libraries Using a ClonePix 2 Colony Sorter. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(20). https://doi.org/10.3390/ijms20205119 Islam, T., Naik, A. D., Hashimoto, Y., Menegatti, S., & Carbonell, R. G. (2019). Optimization of Sequence, Display, and Mode of Operation of IgG-Binding Peptide Ligands to Develop Robust, High-Capacity Affinity Adsorbents That Afford High IgG Product Quality. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(1). https://doi.org/10.3390/ijms20010161 Naika, A. D., Islam, T., Terasaka, T., Ohara, Y., Hashimoto, Y., Menegatti, S., & Carbonell, R. (2019). Silica resins and peptide ligands to develop disposable affinity adsorbents for antibody purification. BIOCHEMICAL ENGINEERING JOURNAL, 145, 53–61. https://doi.org/10.1016/j.bej.2018.07.011 Lavoie, R. A., Fazio, A., Blackburn, R. K., Goshe, M. B., Carbonell, R. G., & Menegatti, S. (2019). Targeted Capture of Chinese Hamster Ovary Host Cell Proteins: Peptide Ligand Discovery. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 20(7). https://doi.org/10.3390/ijms20071729 Islam, N., Gurgel, P. V., Rojas, O. J., & Carbonell, R. G. (2019). Use of a Branched Linker for Enhanced Biosensing Properties in IgG Detection from Mixed Chinese Hamster Ovary Cell Cultures. BIOCONJUGATE CHEMISTRY, 30(3), 815–825. https://doi.org/10.1021/acs.bioconjchem.8b00918 Kish, W. S., Roach, M. K., Sachi, H., Naik, A. D., Menegatti, S., & Carbonell, R. G. (2018). Purification of human erythropoietin by affinity chromatography using cyclic peptide ligands. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1085, 1–12. https://doi.org/10.1016/j.jchromb.2018.03.039 Kish, W. S., Sachi, H., Naik, A. D., Roach, M. K., Bobay, B. G., Blackburn, R. K., … Carbonell, R. G. (2017). Design, selection, and development of cyclic peptide ligands for human erythropoietin. JOURNAL OF CHROMATOGRAPHY A, 1500, 105–120. https://doi.org/10.1016/j.chroma.2017.04.019 Shen, F., Rojas, O. J., Genzer, J., Gurgel, P. V., & Carbonell, R. G. (2016). Affinity interactions of human immunoglobulin G with short peptides: role of ligand spacer on binding, kinetics, and mass transfer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 408(7), 1829–1841. https://doi.org/10.1007/s00216-015-9135-y Menegatti, S., Bobay, B. G., Ward, K. L., Islam, T., Kish, W. S., Naik, A. D., & Carbonell, R. G. (2016). Design of protease-resistant peptide ligands for the purification of antibodies from human plasma. Journal of Chromatography A, 1445, 93–104. https://doi.org/10.1016/j.chroma.2016.03.087 Heller, M., Wimbish, R., Gurgel, P. V., Pourdeyhimi, B., & Carbonell, R. G. (2016). Reducing diffusion limitations in Ion exchange grafted membranes using high surface area nonwovens. JOURNAL OF MEMBRANE SCIENCE, 514, 53–64. https://doi.org/10.1016/j.memsci.2016.02.046 Liu, H., Gurgel, P. V., & Carbonell, R. G. (2015). Preparation and characterization of anion exchange adsorptive nonwoven membranes with high protein binding capacity. JOURNAL OF MEMBRANE SCIENCE, 493, 349–359. https://doi.org/10.1016/j.memsci.2015.06.002 Billakanti, J. M., Fee, C. J., Naik, A. D., & Carbonell, R. G. (2014). Application of peptide chromatography for the isolation of antibodies from bovine skim milk, acid whey and colostrum. FOOD AND BIOPRODUCTS PROCESSING, 92(C2), 199–207. https://doi.org/10.1016/j.fbp.2014.01.002 Ruiz, J., Gilleskie, G. L., Brown, P., Burnett, B., & Carbonell, R. G. (2014). Comprehensive Hands-on Training for Influenza Vaccine Manufacturing: A WHO-BARDA-BTEC Partnership for Global Workforce Development. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 42(5), 414–419. https://doi.org/10.1002/bmb.20817 Islam, N., Shen, F., Gurgel, P. V., Rojas, O. J., & Carbonell, R. G. (2014). Dynamic and equilibrium performance of sensors based on short peptide ligands for affinity adsorption of human IgG using surface plasmon resonance. BIOSENSORS & BIOELECTRONICS, 58, 380–387. https://doi.org/10.1016/j.bios.2014.02.069 Islam, N., Gurgel, P. V., Rojas, O. J., & Carbonell, R. G. (2014). Effects of Composition of Oligo(ethylene glycol)-Based Mixed Monolayers on Peptide Grafting and Human Immunoglobulin Detection. JOURNAL OF PHYSICAL CHEMISTRY C, 118(10), 5361–5373. https://doi.org/10.1021/jp411469u Susanti, R. F., Han, Y. S., Kim, J., Lee, Y. H., & Carbonell, R. G. (2013). A new strategy for ultralow biofouling membranes: Uniform and ultrathin hydrophilic coatings using liquid carbon dioxide. JOURNAL OF MEMBRANE SCIENCE, 440, 88–97. https://doi.org/10.1016/j.memsci.2013.03.068 Liu, Z., Gurgel, P. V., & Carbonell, R. G. (2013). Affinity chromatographic purification of human immunoglobulin M from human B lymphocyte cell culture supernatant. BIOCHEMICAL ENGINEERING JOURNAL, 70, 63–70. https://doi.org/10.1016/j.bej.2012.10.003 Liu, Z., Gurgel, P. V., & Carbonell, R. G. (2013). Affinity chromatographic purification of human immunoglobulin a from chinese hamster ovary cell culture supernatant. BIOTECHNOLOGY PROGRESS, 29(1), 91–98. https://doi.org/10.1002/btpr.1652 Liu, H., Zheng, Y., Gurgel, P. V., & Carbonell, R. G. (2013). Affinity membrane development from PBT nonwoven by photo-induced graft polymerization, hydrophilization and ligand attachment. JOURNAL OF MEMBRANE SCIENCE, 428, 562–575. https://doi.org/10.1016/j.memsci.2012.09.047 Zhang, Y., Carbonell, R. G., & Rojas, O. J. (2013). Bioactive Cellulose Nanofibrils for Specific Human IgG Binding. BIOMACROMOLECULES, 14(12), 4161–4168. https://doi.org/10.1021/bm4007979 Kish, W. S., Naik, A. D., Menegatti, S., & Carbonell, R. G. (2013). Peptide-based affinity adsorbents with high binding capacity for the purification of monoclonal antibodies. Industrial & Engineering Chemistry Research, 52(26), 8800–8811. https://doi.org/10.1021/ie302345w Menegatti, S., Ward, K. L., Naik, A. D., Kish, W. S., Blackburn, R. K., & Carbonell, R. G. (2013). Reversible cyclic peptide libraries for the discovery of affinity ligands. Analytical Chemistry, 85(19), 9229–9237. https://doi.org/10.1021/ac401954k Zhang, Y., Islam, N., Carbonell, R. G., & Rojas, O. J. (2013). Specific Binding of Immunoglobulin G with Bioactive Short Peptides Supported on Antifouling Copolymer Layers for Detection in Quartz Crystal Microgravimetry and Surface Plasmon Resonance. ANALYTICAL CHEMISTRY, 85(2), 1106–1113. https://doi.org/10.1021/ac302874s Zhang, Y., Islam, N., Carbonell, R. G., & Rojas, O. J. (2013). Specificity and Regenerability of Short Peptide Ligands Supported on Polymer Layers for Immunoglobulin G Binding and Detection. ACS APPLIED MATERIALS & INTERFACES, 5(16), 8030–8037. https://doi.org/10.1021/am4021186 Menegatti, S., Hussain, M., Naik, A. D., Carbonell, R. G., & Rao, B. M. (2013). mRNA display selection and solid-phase synthesis of Fc-binding cyclic peptide affinity ligands. Biotechnology and Bioengineering, 110(3), 857–870. https://doi.org/10.1002/bit.24760 Menegatti, S., Naik, A. D., Gurgel, P. V., & Carbonell, R. G. (2012). Alkaline-stable peptide ligand affinity adsorbents for the purification of biomolecules. Journal of Chromatography A, 1245, 55–64. https://doi.org/10.1016/j.chroma.2012.04.072 Gera, N., Hill, A. B., White, D. P., Carbonell, R. G., & Rao, B. M. (2012). Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold. PLOS ONE, 7(11). https://doi.org/10.1371/journal.pone.0048928 Heldt, C. L., Gurgel, P. V., Jaykus, L.-A., & Carbonell, R. G. (2012). Porcine parvovirus removal using trimer and biased hexamer peptides. Biotechnology Journal, 7(4), 558–565. https://doi.org/10.1002/biot.201000397 Naik, A. D., Menegatti, S., Reese, H. R., Gurgel, P. V., & Carbonell, R. G. (2012). Process for purification of monoclonal antibody expressed in transgenic Lemna plant extract using dextran-coated charcoal and hexamer peptide affinity resin. Journal of Chromatography A, 1260, 61–66. https://doi.org/10.1016/j.chroma.2012.08.043 Liu, Z., Gurgel, P. V., & Carbonell, R. G. (2012). Purification of human immunoglobulins A, G and M from Cohn fraction II/III by small peptide affinity chromatography. JOURNAL OF CHROMATOGRAPHY A, 1262, 169–179. https://doi.org/10.1016/j.chroma.2012.09.026 Menegatti, S., Naik, A. D., Gurgel, P. V., & Carbonell, R. G. (2012). Purification of polyclonal antibodies from Cohn fraction II + III, skim milk, and whey by affinity chromatography using a hexamer peptide ligand. Journal of Separation Science, 35(22), 3139–3148. https://doi.org/10.1002/jssc.201200199 Zheng, Y., Gurgel, P. V., & Carbonell, R. G. (2011). Effects of UV Exposure and Initiator Concentration on the Spatial Variation of Poly(glycidyl methacrylate) Grafts on Nonwoven Fabrics. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 50(10), 6115–6123. https://doi.org/10.1021/ie1021333 Liu, Z., Gurgel, P. V., & Carbonell, R. G. (2011). Effects of peptide density and elution pH on affinity chromatographic purification of human immunoglobulins A and M. JOURNAL OF CHROMATOGRAPHY A, 1218(46), 8344–8352. https://doi.org/10.1016/j.chroma.2011.09.038 Cain, N., Roberts, G., Kiserow, D., & Carbonell, R. (2011). Modeling the thermodynamic and transport properties of decahydronaphthalene/propane mixtures: Phase equilibria, density, and viscosity. FLUID PHASE EQUILIBRIA, 305(1), 25–33. https://doi.org/10.1016/j.fluid.2011.02.009 Naik, A. D., Menegatti, S., Gurgel, P. V., & Carbonell, R. G. (2011). Performance of hexamer peptide ligands for affinity purification of immunoglobulin G from commercial cell culture media. Journal of Chromatography A, 1218(13), 1691–1700. https://doi.org/10.1016/j.chroma.2010.11.071 Cain, N., Haywood, A., Roberts, G., Kiserow, D., & Carbonell, R. (2011). Polystyrene/Decahydronaphthalene/Propane Phase Equilibria and Polymer Conformation Properties from Intrinsic Viscosities. JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 49(15), 1093–1100. https://doi.org/10.1002/polb.22282 Herigstad, M. O., Gurgel, P. V., & Carbonell, R. G. (2011). Transport and Binding Characterization of a Novel Hybrid Particle Impregnated Membrane Material for Bioseparations. BIOTECHNOLOGY PROGRESS, 27(1), 129–139. https://doi.org/10.1002/btpr.502 Yang, H. O., Gurgel, P. V., Williams, D. K., Bobay, B. G., Cavanagh, J., Muddiman, D. C., & Carbonell, R. G. (2010). Binding site on human immunoglobulin G for the affinity ligand HWRGWV. Journal of Molecular Recognition, 23(3), 271–282. Kim, J., & Carbonell, R. G. (2010). Deposition of palladium catalyzed copper films by the displacement of two immiscible supercritical phases and subsequent reaction. JOURNAL OF MATERIALS CHEMISTRY, 20(19), 3973–3978. https://doi.org/10.1039/b925959g Zheng, Y., Liu, H., Gurgel, P. V., & Carbonell, R. G. (2010). Polypropylene nonwoven fabrics with conformal grafting of poly(glycidyl methacrylate) for bioseparations. JOURNAL OF MEMBRANE SCIENCE, 364(1-2), 362–371. https://doi.org/10.1016/j.memsci.2010.08.037 Kim, J., Rolland, J. P., Carbonell, R. G., & DeSimone, J. M. (2010). Ultrathin Cross-Linked Perfluoropolyether Film Coatings from Liquid CO2 and Subsequent UV Curing. CHEMISTRY OF MATERIALS, 22(8), 2411–2413. https://doi.org/10.1021/cm903598v Yang, H., Gurgel, P. V., Williams, D. K., Jr, Bobay, B. G., Cavanagh, J., Muddiman, D. C., & Carbonell, R. G. (2009). Binding site on human immunoglobulin G for the affinity ligand HWRGWV. Journal of Molecular Recognition, n/a-n/a. https://doi.org/10.1002/jmr.967 Kim, J., Taylor, D., DeYoung, J., McClain, J. B., DeSimone, J. M., & Carbonell, R. G. (2009). Deposition of Copper Particles and Films by the Displacement of Two Immiscible Supercritical Phases and Subsequent Reaction. Chemistry of Materials, 21(5), 913–924. https://doi.org/10.1021/cm802659j Dong, L. B., Carbonell, R. G., Roberts, G. W., & Kiserow, D. J. (2009). Determination of polystyrene-carbon dioxide-decahydronaphthalene solution properties by high pressure dynamic light scattering. POLYMER, 50(24), 5728–5732. https://doi.org/10.1016/j.polymer.2009.09.069 Martín del Valle Eva M., Galán Miguel A., & Carbonell, R. G. (2009). Drug Delivery Technologies: The Way Forward in the New Decade. Industrial & Engineering Chemistry Research, 48(5), 2475–2486. https://doi.org/10.1021/ie800886m Heldt, C. L., Gurgel, P. V., Jaykus, L.-A., & Carbonell, R. G. (2009). Influence of Peptide Ligand Surface Density and Ethylene Oxide Spacer Arm on the Capture of Porcine Parvovirus. BIOTECHNOLOGY PROGRESS, 25(5), 1411–1418. https://doi.org/10.1002/btpr.236 Zweber, A. E., Wagner, M., DeYoung, J., & Carbonell, R. G. (2009). Mechanism of Extreme Ultraviolet Photoresist Development with a Supercritical CO2 Compatible Salt. LANGMUIR, 25(11), 6176–6190. https://doi.org/10.1021/la8043158 Carla, V., Hussain, Y., Grant, C., Sarti, G. C., Carbonell, R. G., & Doghieri, F. (2009). Modeling Sorption Kinetics of Carbon Dioxide in Glassy Polymeric Films Using the Nonequilibrium Thermodynamics Approach. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 48(8), 3844–3854. https://doi.org/10.1021/ie800655w Yang, H., Gurgel, P. V., & Carbonell, R. G. (2009). Purification of human immunoglobulin G via Fc-specific small peptide ligand affinity chromatography. JOURNAL OF CHROMATOGRAPHY A, 1216(6), 910–918. https://doi.org/10.1016/j.chroma.2008.12.004 Zweber, A. E., Wagner, M., & Carbonell, R. G. (2009). Sorption of CO2 and a CO2 Compatible Salt into an Extreme Ultraviolet Photoresist Film on a SiO2 Substrate. JOURNAL OF PHYSICAL CHEMISTRY B, 113(29), 9687–9693. https://doi.org/10.1021/jp900481j Heldt, C. L., Gurgel, P. V., Jaykus, L.-A., & Carbonell, R. G. (2008). Identification of trimeric peptides that bind porcine parvovirus from mixtures containing human blood plasma. BIOTECHNOLOGY PROGRESS, Vol. 24, pp. 554–560. https://doi.org/10.1021/bp070412c Carbonell, R. G., Shen, H., Gurgel, P. V., Wiltshire-Lyerly, V., Hammond, D. J., & Burton, S. J. (2008). Prion protein binding materials and methods of use. Washington, DC: U.S. Patent and Trademark Office. Tombokan, X. C., Aguda, R. M., Danehower, D. A., Kilpatrick, P. K., & Carbonell, R. G. (2008, June). Three-component phase behavior of the sclareol-ethyl lactate-carbon dioxide system for GAS applications. JOURNAL OF SUPERCRITICAL FLUIDS, Vol. 45, pp. 146–155. https://doi.org/10.1016/j.supflu.2007.12.007 Kim, J., & Carbonell, R. G. (2007). Deposition of poly[2-(perfluorooctyl)ethyl acrylate] from liquid CO2 high-pressure free meniscus coating—Uniformity and morphology. The Journal of Supercritical Fluids, 42(1), 129–141. https://doi.org/10.1016/j.supflu.2007.01.012 Kim, J., McClain, J. B., & Carbonell, R. G. (2007). Deposition of poly[2-(perfluorooctyl)ethyl acrylate] on silicon wafers by the displacement of two immiscible supercritical phases (DISP). JOURNAL OF SUPERCRITICAL FLUIDS, 43(1), 139–149. https://doi.org/10.1016/j.supflu.2007.05.003 Rosa, P. T. V., Santana, C. C., & Carbonell, R. G. (2007). Determination of the liquid pool surfactant and protein concentration for semi-batch foam fractionation columns. BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING, 24(1), 1–14. https://doi.org/10.1590/S0104-66322007000100001 Marias, F., Mancini, F., Cansell, F., & Mercadier, J. (2007). Hydrothermal oxidation treatment of solid particles between 250 and 350 degrees C: Modelling and experiments. JOURNAL OF SUPERCRITICAL FLUIDS, 41(3), 352–360. https://doi.org/10.1016/j.supflu.2007.01.002 Kim, J., Efimenko, K., Genzer, J., & Carbonell, R. G. (2007). Surface properties of poly[2-(perfluorooctyl)ethyl acrylate] deposited from liquid CO2 high-pressure free meniscus coating. MACROMOLECULES, 40(3), 588–597. https://doi.org/10.1021/ma0623791 Heldt, C. L., Hernandez, R., Mudiganti, U., Gurgel, P. V., Brown, D. T., & Carbonell, R. G. (2006). A colorimetric assay for viral agents that produce cytopathic effects. Journal of Virological Methods, 135(1), 56–65. https://doi.org/10.1016/j.j.viromet.2006.01.022 Heldt, C. L., Hernandez, R., Mudiganti, U., Gurgel, P. V., Brown, D. T., & Carbonell, R. G. (2006). A colorimetric assay for viral agents that produce cytopathic effects. Journal of Virological Methods, 135(1), 56–65. https://doi.org/10.1016/j.jviromet.2006.01.022 Boggiano, M. K., Vellenga, D., Carbonell, R., Ashby, V. S., & DeSimone, J. M. (2006). Alicyclic photoresists for CO2-based next-generation microlithography: A tribute to James E. McGrath. POLYMER, 47(11), 4012–4017. https://doi.org/10.1016/j.polymer.2006.03.001 Kim, J., & Carbonell, R. G. (2006). Deposition of small organic molecules by the displacement of two immiscible supercritical phases. LANGMUIR, 22(5), 2117–2129. https://doi.org/10.1021/la052625m Wang, G., & Carbonell, R. G. (2006). Design of Adsorptive Columns for Specific Pathogen Removal: Application to Staphylococcal Enterotoxin B. Biotechnology Progress, 22(5), 1358–1367. https://doi.org/10.1021/bp060126l Wang, G. Q., & Carbonell, R. G. (2006). Design of adsorptive columns for specific pathogen removal: Application to staphylococcal enterotoxin B. Biotechnology Progress, 22(5), 1358–1367. https://doi.org/10.1021/pb060126l Gregori, L., Gurgel, P. V., Lathrop, J. T., Edwardson, P., Lambert, B. C., Carbonell, R. G., … Rohwer, R. G. (2006). Reduction in infectivity of endogenous transmissible spongiform encephalopathies present in blood by adsorption to selective affinity resins. LANCET, 368(9554), 2226–2230. https://doi.org/10.1016/S0140-6736(06)69897-8 Gregori, L., Lambert, B. C., Gurgel, P. V., Gheorghiu, L., Edwardson, P., Lathrop, J. T., … Rohwer, R. G. (2006). Reduction of transmissible spongiform encephalopathy infectivity from human red blood cells with prion protein affinity ligands. TRANSFUSION, 46(7), 1152–1161. https://doi.org/10.1111/j.1537-2995.2006.00865.x Visintin, P. M., Eichenlaub, S. K., Portnow, L. E., Carbonell, R. G., Beaudoin, S. P., Schauer, C. K., & DeSimone, J. M. (2006). Studies on CO2-based slurries and fluorinated silica and alumina particles for chemical mechanical polishing of copper films. JOURNAL OF THE ELECTROCHEMICAL SOCIETY, 153(12), G1064–G1071. https://doi.org/10.1149/1.2358085 Kim, J., Novick, B. J., DeSimone, J. M., & Carbonell, R. G. (2006). Ultrathin film deposition by liquid CO2 free meniscus coating-uniformity and morphology. LANGMUIR, 22(2), 642–657. https://doi.org/10.1021/la0521600 Wang, G. Q., & Carbonell, R. G. (2005). Characterization of a peptide affinity support that binds selectively to staphylococcal enterotoxin B. JOURNAL OF CHROMATOGRAPHY A, 1078(1-2), 98–112. https://doi.org/10.1016/j.chroma.2005.05.010 Cotugno, S., Di Maio, E., Mensitieri, G., Iannace, S., Roberts, G. W., Carbonell, R. G., & Hopfenberg, H. B. (2005). Characterization of microcellular biodegradable polymeric foams produced from supercritical carbon dioxide solutions. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 44(6), 1795–1803. https://doi.org/10.1021/ie049445c Visintin, P. M., Carbonell, R. G., Schauer, C. K., & DeSimone, J. M. (2005). Chemical functionalization of silica and alumina particles for dispersion in carbon dioxide. LANGMUIR, 21(11), 4816–4823. https://doi.org/10.1021/la047823c Yang, H., Gurgel, P. V., & Carbonell, R. G. (2005). Hexamer peptide affinity resins that bind the Fc region of human immunoglobulin G. JOURNAL OF PEPTIDE RESEARCH, 66, 120–137. https://doi.org/10.1111/j.1747-0285.2006.00342.x Xu, D. W., Carbonell, R. G., Kiserow, D. J., & Roberts, G. W. (2005). Hydrogenation of polystyrene in CO2-expanded solvents: Catalyst poisoning. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 44(16), 6164–6170. https://doi.org/10.1021/ie040243q Carla, V., Wang, K., Hussain, Y., Efimenko, K., Genzer, J., Grant, C., … Doghieri, F. (2005). Nonequilibrium model for sorption and swelling of bulk glassy polymer films with Supercritical carbon dioxide. MACROMOLECULES, 38(24), 10299–10313. https://doi.org/10.1021/ma0506684 Xu, D., Carbonell, R. G., Roberts, G. W., & Kiserow, D. J. (2005). Phase equilibrium for the hydrogenation of polystyrene in CO2–swollen solvents. The Journal of Supercritical Fluids, 34(1), 1–9. https://doi.org/10.1016/j.supflu.2004.09.004 Wang, G., Salm, J. R., Gurgel, P. V., & Carbonell, R. G. (2005). Small Peptide Ligands for Affinity Separations of Biological Molecules. CHEMICAL ENGINEERING TRENDS AND DEVELOPMENTS, pp. 63–83. https://doi.org/10.1002/0470025018.ch3 Hoggan, E. N., Wang, K., Flowers, D., DeSimone, J. M., & Carbonell, R. G. (2004). "dry" lithography using liquid and supercritical carbon dioxide based chemistries and processes. IEEE TRANSACTIONS ON SEMICONDUCTOR MANUFACTURING, 17(4), 510–516. https://doi.org/10.1109/tsm.2004.837002 Wang, G., De, J., Schoeniger, J. S., Roe, D. C., & Carbonell, R. G. (2004). A hexamer peptide ligand that binds selectively to staphylococcal enterotoxin B: isolation from a solid phase combinatorial library. JOURNAL OF PEPTIDE RESEARCH, 64(2), 51–64. https://doi.org/10.1111/j.1399-3011.2004.00170.x Jones, C. A., Zweber, A., DeYoung, J. P., McClain, J. B., Carbonell, R., & DeSimone, J. M. (2004). [Review of Applications of "dry" processing in the microelectronics industry using carbon dioxide]. CRITICAL REVIEWS IN SOLID STATE AND MATERIALS SCIENCES, 29(3-4), 97–109. https://doi.org/10.1080/10408430490888968 DeSimone, J. M., Carbonell, R. G., Kendall, J., & McAdams, C. L. (2004). CO2-processes photoresists, polymers, and photoactive compounds for microlithography. Washington, DC: U.S. Patent and Trademark Office. DeSimone, J. M., Birnbaum, E., Carbonell, R. G., Crette, S., McClain, J. B., McCleskey, T. M., … Tumas, W. (2004). Carbon dioxide-soluble polymers and swellable polymers for carbon dioxide applications. Washington, DC: U.S. Patent and Trademark Office. Novick, B. J., DeSimone, J. M., & Carbonell, R. G. (2004). Deposition of Thin Polymeric Films from Liquid Carbon Dioxide Using a High-Pressure Free-Meniscus Coating Process. Industrial & Engineering Chemistry Research, 43(2), 515–524. https://doi.org/10.1021/ie030688z Hoggan, E. N., Flowers, D., Wang, K., DeSimone, J. M., & Carbonell, R. G. (2004). Spin coating of photoresists using liquid carbon dioxide. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 43(9), 2113–2122. https://doi.org/10.1021/ie0308543 Zaki, N. N., Carbonell, R. G., & Kilpatrick, P. K. (2003). A novel process for demulsification of water-in-crude oil emulsions by dense carbon dioxide. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 42(25), 6661–6672. https://doi.org/10.1021/ie0303597 Carbonell, R. G., DeSimone, J. M., & Novick, B. J. (2003). Apparatus for meniscus coating with liquid carbon dioxide. Washington, DC: U.S. Patent and Trademark Office. Xu, D. W., Carbonell, R. G., Kiserow, D. J., & Roberts, G. W. (2003). Kinetic and transport processes in the heterogeneous catalytic hydrogenation of polystyrene. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 42(15), 3509–3515. https://doi.org/10.1021/ie0301841 Shah, P. S., Novick, B. J., Hwang, H. S., Lim, K. T., Carbonell, R. G., Johnston, K. P., & Korgel, B. A. (2003). Kinetics of nonequilibrium nanocrystal monolayer formation: Deposition from liquid carbon dioxide. NANO LETTERS, 3(12), 1671–1675. https://doi.org/10.1021/nl034793+ Carbonell, R. G., DeSimone, J. M., & Novick, B. J. (2003). Method for meniscuscoating a substrate with a polymeric precurso. Washington, DC: U.S. Patent and Trademark Office. Zaki, N. N., Kilpatrick, P. K., & Carbonell, R. G. (2003). Methods of demulsifying emulsions using carbon dioxide. Washington, DC: U.S. Patent and Trademark Office. Elbaccouch, M. M., Bondar, VI, Carbonell, R. G., & Grant, C. S. (2003). Phase equilibrium behavior of the binary systems CO2 plus nonadecane and CO2 plus soysolv and the ternary system CO2 plus soysolv plus quaternary ammonium chloride surfactant. JOURNAL OF CHEMICAL AND ENGINEERING DATA, 48(6), 1401–1406. https://doi.org/10.1021/je020201d Kaufman, D. B., Hentsch, M. E., Baumbach, G. A., Buettner, J. A., Dadd, C. A., Huang, P. Y., … Carbonell, R. G. (2002). Affinity purification of fibrinogen using a ligand from a peptide library. BIOTECHNOLOGY AND BIOENGINEERING, 77(3), 278–289. https://doi.org/10.1002/bit.10120 Henon, F. E., Carbonell, R. G., & DeSimone, J. M. (2002). Effect of polymer coatings from CO2 on water-vapor transport in porous media. AICHE JOURNAL, 48(5), 941–952. https://doi.org/10.1002/aic.690480504 Efimenko, K., Novick, B., Carbonell, R. G., DeSimone, J. M., & Genzer, J. (2002). Formation of self-assembled monolayers of semifluorinated and hydrocarbon chlorosilane precursors on silica surfaces from liquid carbon dioxide. LANGMUIR, 18(16), 6170–6179. https://doi.org/10.1021/la011813j Lakota, A., Levec, J., & Carbonell, R. G. (2002). Hydrodynamics of trickling flow in packed beds: Relative permeability concept. AICHE JOURNAL, 48(4), 731–738. https://doi.org/10.1002/aic.690480408 Carbonell, R. G., & DeSimone, J. M. (2002). Spin cleaning methods. Washington, DC: U.S. Patent and Trademark Office. DeSimone, J. M., & Carbonell, R. G. (2001). Apparatus for liquid carbon dioxide systems. Washington, DC: U.S. Patent and Trademark Office. DeSimone, J. M., Carbonell, R. G., Crette, S. A., & Kendall, J. L. (2001). Enzyme catalysis in carbon dioxide fluids. Washington, DC: U.S. Patent and Trademark Office. Chernyak, Y., Henon, F., Harris, R. B., Gould, R. D., Franklin, R. K., Edwards, JR, … Carbonell, R. G. (2001). Formation of perfluoropolyether coatings by the rapid expansion of supercritical solutions (RESS) process. Part 1: Experimental results. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 40(26), 6118–6126. https://doi.org/10.1021/ie010267m Franklin, R. K., Edwards, JR, Chernyak, Y., Gould, R. D., Henon, F., & Carbonell, R. G. (2001). Formation of perfluoropolyether coatings by the rapid expansion of supercritical solutions (RESS) process. Part 2: Numerical modeling. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 40(26), 6127–6139. https://doi.org/10.1021/ie010268e Gurgel, P. V., Carbonell, R. G., & Swaisgood, H. E. (2001). Identification of peptide ligands generated by combinatorial chemistry that bind alpha-lactalbumin. SEPARATION SCIENCE AND TECHNOLOGY, 36(11), 2411–2431. https://doi.org/10.1081/SS-100106100 DeSimone, J. M., & Carbonell, R. G. (2001). Methods of spin cleaning substrates using carbon dioxide liquid. Washington, DC: U.S. Patent and Trademark Office. Martinache, J. D., Royer, JR, Siripurapu, S., Henon, F. E., Genzer, J., Khan, S. A., & Carbonell, R. G. (2001). Processing of polyamide 11 with supercritical carbon dioxide. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 40(23), 5570–5577. https://doi.org/10.1021/ie010410b Gurgel, P. V., Carbonell, R. G., & Swaisgood, H. E. (2001). Studies of the binding of alpha-lactalbumin to immobilized peptide ligands. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 49(12), 5765–5770. https://doi.org/10.1021/jf010462b Kaufman, D. B., Hayes, T., Buettner, J., Hammond, D. J., & Carbonell, R. G. (2000). Chromatographic resolution of tryptophan enantiomers with L-Leu-L-Leu-L-Leu peptide - Effects of mobile phase composition and chromatographic support. JOURNAL OF CHROMATOGRAPHY A, 874(1), 21–26. https://doi.org/10.1016/S0021-9673(99)01299-6 Bastek, P. D., Land, J. M., Baumbach, G. A., Hammond, D. H., & Carbonell, R. G. (2000). Discovery of alpha-1-proteinase inhibitor binding peptides from the screening of a solid phase combinatorial peptide library. SEPARATION SCIENCE AND TECHNOLOGY, 35(11), 1681–1706. https://doi.org/10.1081/SS-100102488 Gurgel, P. V., Carbonell, R. G., & Swaisgood, H. E. (2000). Fractionation of whey proteins with a hexapeptide ligand affinity resin. BIOSEPARATION, 9(6), 385–392. https://doi.org/10.1023/A:1011191818927 Roberts, G. W., Carbonell, R. G., & Saez, A. E. (2000). Gas-lift reactors for rapid reactions with appreciable gas consumption. Chemical Engineering & Technology, 23(1), 80–87. https://doi.org/10.1002/(sici)1521-4125(200001)23:1<80::aid-ceat80>3.0.co;2-m Carbonel, R. G., DeSimone, J. M., & Henon, F. E. (2000). Method and compositions for protecting civil infrastructure. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., DeSimone, J. M., & Novick, B. J. (2000). Method for meniscus coating with liquid carbon. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., DeSimone, J. M., & Novick, B. J. (2000). Method for meniscus coating with liquid carbon dioxide. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G. (2000). Multiphase flow models in packed beds. OIL & GAS SCIENCE AND TECHNOLOGY-REVUE D IFP ENERGIES NOUVELLES, 55(4), 417–425. https://doi.org/10.2516/ogst:2000030 Chen, L. A., Carbonell, R. G., & Serad, G. A. (2000). Recovery of proteins and other biological compounds from food processing wastewaters using fibrous materials and polyelectrolytes. WATER RESEARCH, 34(2), 510–518. https://doi.org/10.1016/S0043-1354(99)00152-9 Kabin, J. A., Withers, S. T., Grant, C. S., Carbonell, R. G., & Saez, A. E. (2000). Removal of solid organic films from rotating disks using emulsion cleaners. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 228(2), 344–358. https://doi.org/10.1006/jcis.2000.6832 Huang, P. Y., & Carbonell, R. G. (1999). Affinity chromatographic screening of soluble combinatorial peptide libraries. BIOTECHNOLOGY AND BIOENGINEERING, 63(6), 633–641. https://doi.org/10.1002/(SICI)1097-0290(19990620)63:6<633::AID-BIT1>3.0.CO;2-C Marquez, H. A., Saez, A. E., Carbonell, R. G., & Roberts, G. W. (1999). Coupling of hydrodynamics and chemical reaction in gas-lift reactors. AIChE Journal, 45(2), 410–423. https://doi.org/10.1002/aic.690450220 Marquez, M. A., Amend, R. J., Carbonell, R. G., Saez, A. E., & Roberts, G. W. (1999, July). Hydrodynamics of gas-lift reactors with a fast, liquid-phase reaction. CHEMICAL ENGINEERING SCIENCE, Vol. 54, pp. 2263–2271. https://doi.org/10.1016/S0009-2509(98)00351-0 Lucena, S. L., Carbonell, R. G., & Santana, C. C. (1999, February). Peptide affinity chromatography process for adsorption of fibrinogen. POWDER TECHNOLOGY, Vol. 101, pp. 173–177. https://doi.org/10.1016/S0032-5910(98)00169-7 Moraes, A. M., Santana, M. H. A., & Carbonell, R. G. (1999). Preparation and characterization of liposomal systems entrapping the boronated compound o-carboranylpropylamine. Journal of Microencapsulation, 16(5), 647–664. https://doi.org/10.1080/026520499288834 Chen, L. A., Carbonell, R. G., & Serad, G. A. (1999). Recovery of proteins and other biological compounds using fibrous materials: I. Adsorption by salt addition. Journal of Chemical Technology and Biotechnology, 74(8), 733–739. https://doi.org/10.1002/(sici)1097-4660(199908)74:8<733::aid-jctb111>3.0.co;2-4 Chen, L. A., Carbonell, R. G., & Serad, G. A. (1999). Recovery of proteins and other biological compounds using fibrous materials: II. Flocculation by polyelectrolyte addition. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 74(8), 740–750. https://doi.org/10.1002/(SICI)1097-4660(199908)74:8<740::AID-JCTB112>3.0.CO;2-1 Kabin, J. A., Saez, A. E., Grant, C. S., & Carbonell, R. G. (1999). Removal rates of major and trace components of an organic film using aqueous nonionic surfactant solutions. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 38(3), 683–691. https://doi.org/10.1021/ie980587e DeSimone, J. M., & Carbonell, R. G. (1999). Spin coating method and apparatus for liquid carbon dioxide systems. Washington, DC: U.S. Patent and Trademark Office. Henon, F. E., Camaiti, M., Burke, A. L. C., Carbonell, R. G., DeSimone, J. M., & Piacenti, F. (1999). Supercritical CO2 as a solvent for polymeric stone protective materials. JOURNAL OF SUPERCRITICAL FLUIDS, 15(2), 173–179. https://doi.org/10.1016/S0896-8446(99)00005-4 Saez, A. E., Marquez, M. A., Roberts, G. W., & Carbonell, R. G. (1998). Hydrodynamic model for gas-lift reactors. AICHE JOURNAL, 44(6), 1413–1423. https://doi.org/10.1002/aic.690440619 Kabin, J. A., Tolstedt, S. L., Saez, A. E., Grant, C., & Carbonell, R. G. (1998). Removal of organic films from rotating disks using aqueous solutions of nonionic surfactants: Effect of surfactant molecular structure. Journal of Colloid and Interface Science, 206(1), 102–111. https://doi.org/10.1006/jcis.1998.5689 Mondorf, K., Kaufman, D. B., & Carbonell, R. G. (1998). Screening of combinatorial peptide libraries: Identification of ligands for affinity purification of proteins using a radiological approach. Journal of Peptide Research, 52(6), 526–536. https://doi.org/10.1111/j.1399-3011.1998.tb01257.x Carbonell, R. G., Chen, L. A., & Serad, G. A. (1997). Methods of treating wastewater. Washington, DC: U.S. Patent and Trademark Office. Kilpatrick, P. K., Lisi, J. F., & Carbonell, R. G. (1997). Selective precipitation of antibody with ligand-modified phospholipids: Effect of lipid chain length. BIOTECHNOLOGY PROGRESS, 13(4), 446–452. https://doi.org/10.1021/bp9700521 Beaudoin, S. P., Carbonell, R. G., & Grant, C. S. (1996). Dynamic and equilibrium phase behavior in the C(12)E(5) abietic acid H2O system. JOURNAL OF COLLOID AND INTERFACE SCIENCE, 182(2), 465–472. https://doi.org/10.1006/jcis.1996.0489 Kabin, J. A., Saez, A. E., Grant, C. S., & Carbonell, R. G. (1996). Removal of organic films from rotating disks using aqueous solutions of nonionic surfactants: Film morphology and cleaning mechanisms. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 35(12), 4494–4506. https://doi.org/10.1021/ie960195c BEAUDOIN, S. P., GRANT, C. S., & CARBONELL, R. G. (1995). REMOVAL OF ORGANIC FILMS FROM SOLID-SURFACES USING AQUEOUS-SOLUTIONS OF NONIONIC SURFACTANTS .1. EXPERIMENTS. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 34(10), 3307–3317. https://doi.org/10.1021/ie00037a017 Beaudoin, S. P., Grant, C., & Carbonell, R. G. (1995). Removal of organic films from solid surfaces using aqueous solutions of nonionic surfactants. 2. Theory. Industrial & Engineering Chemistry Research, 34(10), 3318–3325. https://doi.org/10.1021/ie00037a018 Bastek, P. D., Lang, J. M., Baumbach, G. A., & Carbonell, R. G. Alpha-1 proteinase inhibitor binding peptides. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., Kilpatrick, P. K., Torres, J. L., & Guzman, R. Chromatography apparatus. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., DeSimone, J. M., & Henon, F. E. Compositions for protecting civil infrastructure. Washington, DC: U.S. Patent and Trademark Office. Valle, E. M. M., Galan, M. A., & Carbonell, R. G. [Review of Drug delivery technologies: The way forward in the new decade]. Industrial & Engineering Chemistry Research, 48(5), 2475–2486. Roberts, G. W., Xu, D., Kiserow, D. J., & Carbonell, R. G. Hydrogenation of polymers in the presence of supercritical carbon dioxide. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., Kilpatrick, P. K., Jones, M. A., & Singh, A. K. Immunodiagnostic assay using liposomes carrying labels thereof on outer liposome surface. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., Kilpatrick, P., & Saki, N. Methods and compositions for removing residues and substances from substrates using environmentally friendly solvents. Zaki, N. N., Kilpatrick, P. K., & Carbonell, R. G. Methods of deresinating crude oils using carbon dioxide. Mondorf, K., Carbonell, R. C., & Buettner, J. A. Peptide ligands for affinity purification of fibrinogen. Washington, DC: U.S. Patent and Trademark Office. Xu, D. W., Carbonell, R. G., Roberts, G. W., & Kiserow, D. J. Phase equilibrium for the hydrogenation of polystyrene in CO2-swollen solvents. Journal of Supercritical Fluids, 34(1), 09-. Carbonell, R. G., Guzman, R., & Kilpatrick, P. K. Precipitation of multivalent antiligands with affinity surfactants. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., Guzman, R., & Kilpatrick, P. K. Precipitation of multivalent antiligands with affinity surfactants. Washington, DC: U.S. Patent and Trademark Office. Brennecke, J. F., Johnston, K. P., & Carbonell, R. G. Preface: Seventh International Symposium on Supercritical Fluids (ISSF2005). Industrial & Engineering Chemistry Research, 45(10), 3327. Hammond, D. J., Carbonell, R. G., Shen, H., Gurgel, P. V., Wiltshire-Lyerly, V., & Burton, S. J. Prion protein binding materials and methods of use. Kilpatrick, P. K., Carbonell, R. G., & Powers, J. D. Purification by affinity binding to liposomes. Washington, DC: U.S. Patent and Trademark Office. Carbonell, R. G., Yang, H., & Gurgel, P. V. Purification of immunoglobulins using affinity chromatography and peptide ligands. Washington, DC: U.S. Patent and Trademark Office. Chen, C. L., Buettner, J. A., & Carbonell, R. G. Recombinant factor VIII binding peptides. Washington, DC: U.S. Patent and Trademark Office.