Richard G Santangelo

Works (25)

Updated: April 5th, 2024 03:30

2023 journal article

Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, <i>Cimex lectularius</i>, in poultry facilities

PARASITES & VECTORS, 16(1).

By: M. Gonzalez-Morales n, A. Thomson n, J. Yeatts n, H. Enomoto n, A. Haija n, R. Santangelo n, O. Petritz n, R. Crespo n, C. Schal n, R. Baynes n

author keywords: Cimex; Bed bugs; Fluralaner; Pharmacokinetics; Poultry; Ectoparasites
TL;DR: Fluralaner appears to be a promising candidate for bed bug control in poultry farms, with a treatment effect lasting at least 28 days, and quantifiable in the hens’ plasma for at least28 days post-treatment. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 22, 2023

2023 journal article

Spatial distribution of histamine in bed bug-infested homes

SCIENCE OF THE TOTAL ENVIRONMENT, 880.

By: J. Gordon*, R. Santangelo n, M. Gonzalez-Morales n, M. Menechella n, C. Schal n & Z. DeVries*

author keywords: Environmental contaminants; Insects; Asthma; Cimex lectularius; Respiratory health
MeSH headings : Humans; Animals; Insect Control / methods; Bedbugs; Histamine
TL;DR: Results indicate that the bedroom should be the primary focus of histamine mitigation efforts, although histamine can be found throughout the home, and histamine quantified from homes without active bed bug infestations suggests that histamine from previous infestation can persist following pest eradication. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023

2022 article

Multiple Mechanisms Confer Fipronil Resistance in the German Cockroach: Enhanced Detoxification and Rdl Mutation

Gonzalez-Morales, M. A., DeVries, Z. C., Santangelo, R. G., Kakumanu, M. L., & Schal, C. (2022, August 9). (W. Booth, Ed.). JOURNAL OF MEDICAL ENTOMOLOGY, Vol. 8.

Ed(s): W. Booth

author keywords: urban IPM; German cockroach; Blattella germanica; fipronil; insecticide resistance; Rdl; target site insensitivity
MeSH headings : Animals; Blattellidae / genetics; Insecticide Resistance / genetics; Insecticides / pharmacology; Mutation; Pyrazoles
TL;DR: Evaluated five populations of German cockroaches and found that all field-collected strains are homozygous for a mutation that substitutes serine for an alanine in Rdl, and confers low resistance to fipronil, indicating little change in fipronsil resistance over the past 20 yr. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 10, 2022

2022 journal article

Systemic veterinary drugs for control of the common bed bug, Cimex lectularius, in poultry farms

PARASITES & VECTORS, 15(1).

By: M. Gonzalez-Morales n, A. Thomson n, O. Petritz n, R. Crespo n, A. Haija n, R. Santangelo n, C. Schal n

author keywords: Cimex lectularius; Fluralaner; Ivermectin; Systemics; Poultry; Chicken
MeSH headings : Animals; Humans; Bedbugs; Ivermectin / pharmacology; Farms; Poultry; Veterinary Drugs; Chickens; Ectoparasitic Infestations / drug therapy; Ectoparasitic Infestations / prevention & control; Ectoparasitic Infestations / veterinary
TL;DR: The findings suggest that systemic ectoparasitic drugs have great potential for practical use to control bed bug infestations in poultry farms and demonstrate the efficacy of fluralaner (and potentially other isoxazolines) as a potent new active ingredient for bed bug control. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: December 5, 2022

2021 journal article

Human skin triglycerides prevent bed bug (Cimex lectularius L.) arrestment

SCIENTIFIC REPORTS, 11(1).

MeSH headings : Adult; Animals; Bedbugs / metabolism; Bedbugs / pathogenicity; Cues; Feeding Behavior; Female; Host-Parasite Interactions; Humans; Locomotion; Male; Middle Aged; Odorants; Pheromones / metabolism; Skin / metabolism; Skin / parasitology; Triglycerides / metabolism
TL;DR: Results provide strong evidence that the complex of human skin compounds serve as multifunctional semiochemicals for bed bugs, with some odorants attracting host-seeking stages, and others (TAGs and possibly other compounds) preventing bed bug arrestment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 10, 2022

2021 journal article

Mating and starvation modulate feeding and host-seeking responses in female bed bugs, Cimex lectularius

SCIENTIFIC REPORTS, 11(1).

By: A. Saveer n, Z. DeVries n, R. Santangelo n & C. Schal n

MeSH headings : Animals; Bedbugs / pathogenicity; Bedbugs / physiology; Copulation / physiology; Ectoparasitic Infestations / parasitology; Feeding Behavior / physiology; Female; Fertility / physiology; Humans; Reproduction / physiology; Sexual Behavior, Animal / physiology
TL;DR: Results indicate that by adaptively and coordinately expressing behaviors based on the internal physiological state, females maximize their survival and reproductive fitness. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 22, 2021

2021 journal article

Resistance to Fipronil in the Common Bed Bug (Hemiptera: Cimicidae)

JOURNAL OF MEDICAL ENTOMOLOGY, 58(4), 1798–1807.

By: M. Gonzalez-Morales n, Z. DeVries n, A. Sierras n, R. Santangelo n, M. Kakumanu n & C. Schal n

Ed(s): L. Hribar

author keywords: bed bugs; Cimex lectularius; fipronil; insecticide resistance; synergist
MeSH headings : Animals; Bedbugs / drug effects; Bedbugs / genetics; Insect Proteins / genetics; Insecticide Resistance / genetics; Insecticides / pharmacology; Mutation; Pyrazoles / pharmacology; Pyrethrins / pharmacology; Receptors, GABA-A / genetics
TL;DR: Investigating the potential of fipronil resistance in bed bugs found that highly resistant populations were also highly resistant to deltamethrin, suggesting that metabolic enzymes that are responsible for pyrethroid detoxification might also metabolize fipronsil. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 7, 2021

2019 journal article

Exposure risks and ineffectiveness of total release foggers (TRFs) used for cockroach control in residential settings

BMC Public Health, 19(1).

By: Z. DeVries n, R. Santangelo n, J. Crissman n, R. Mick n & C. Schal n

author keywords: Bug bomb; German cockroach; Pesticide residues; Pesticide exposure; Pyrethroids; Total release aerosols
MeSH headings : Animals; Blattellidae / drug effects; Environmental Exposure / adverse effects; Fumigation; Housing; Humans; Insect Control / methods; Insecticide Resistance; Insecticides / adverse effects; Pesticide Residues / analysis; Risk Assessment
TL;DR: The high risks of pesticide exposure associated with TRFs combined with their ineffectiveness in controlling German cockroach infestations call into question their utility in the marketplace, especially because similarly priced and much safer bait products are highly effective in the indoor environment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: February 11, 2019

2019 journal article

Pervasive Resistance to Pyrethroids in German Cockroaches (Blattodea: Ectobiidae) Related to Lack of Efficacy of Total Release Foggers

Journal of Economic Entomology, 112(5), 2295–2301.

By: Z. DeVries n, R. Santangelo n, J. Crissman n, A. Suazo n, M. Kakumanu n & C. Schal n

Ed(s): M. Rust

author keywords: cypermethrin; do-it-yourself pest control; kdr; topical application
MeSH headings : Animals; Biological Assay; Blattellidae; Cockroaches; Insecticide Resistance; Insecticides; Pyrethrins
TL;DR: Investigating insecticide resistance of apartment-collected cockroaches from homes where TRFs failed suggested pyrethroid resistance is a major factor contributing to the failure of TRFs, which were recently shown to be ineffective at reducing German cockroach infestations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: October 21, 2019

2018 journal article

Histamine as an emergent indoor contaminant: Accumulation and persistence in bed bug infested homes

PLOS ONE, 13(2), e0192462.

By: Z. DeVries n, R. Santangelo n, A. Barbarin* & C. Schal n

Ed(s): J. Benoit

MeSH headings : Air Pollution, Indoor / adverse effects; Animals; Bedbugs; Histamine / analysis; Hot Temperature; Humans; Insect Control; Pest Control
TL;DR: The high concentrations, persistence, and proximity to humans during sleep suggest that bed bug-produced histamine may represent an emergent contaminant and pose a serious health risk in the indoor environment. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Hierarchical Genetic Analysis of German Cockroach (Blattella germanica) Populations from within Buildings to across Continents

PLoS ONE, 9(7), e102321.

By: E. Vargo n, J. Crissman n, W. Booth n, R. Santangelo n, D. Mukha & C. Schal n

Ed(s): Z. Adelman

MeSH headings : Animals; Bayes Theorem; Blattellidae / genetics; Cluster Analysis; DNA, Mitochondrial / genetics; Genetic Variation; Housing; Microsatellite Repeats / genetics; Spatial Analysis; Species Specificity
TL;DR: The German cockroach (Blattella germanica) is a widespread urban invader that can actively disperse within buildings but is spread solely by human-mediated dispersal over longer distances; however, its population structure is poorly understood. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2014 journal article

Within-population variability in a moth sex pheromone blend: genetic basis and behavioural consequences

Proceedings of the Royal Society B: Biological Sciences, 281(1779), 20133054.

By: A. Groot n, G. Schöfl*, O. Inglis n, S. Donnerhacke*, A. Classen*, A. Schmalz*, R. Santangelo n, J. Emerson n ...

author keywords: Lepidoptera; Heliothis virescens; quantitative trait locus analysis; delta-11-desaturase; balancing selection; heterozygote advantage
MeSH headings : Animals; Genetic Variation; Inbreeding; Insect Proteins / genetics; Insect Proteins / metabolism; Moths / genetics; Moths / metabolism; Moths / physiology; Phenotype; Quantitative Trait Loci; Sex Attractants / chemistry; Sex Attractants / genetics; Sexual Behavior, Animal
TL;DR: A model in which the QTL is a trans-acting repressor of delta-11 desaturase expression explains many features of the data, and selection favouring heterozygotes which produce more unsaturated components could maintain a polymorphism at this locus. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

One quantitative trait locus for intra‐ and interspecific variation in a sex pheromone

Molecular Ecology, 22(4), 1065–1080.

By: A. Groot*, H. Staudacher*, A. Barthel*, O. Inglis n, G. Schöfl*, R. Santangelo n, S. Gebauer‐Jung*, H. Vogel* ...

author keywords: acetate; acyltransferase; evolution; moth; premating isolation; RAD tagging
MeSH headings : Acetates / chemistry; Acetyltransferases / genetics; Animals; Female; Genes, Insect; Genetic Variation; Genetics, Population; Male; Mexico; Moths / genetics; North Carolina; Phenotype; Quantitative Trait Loci; Reproductive Isolation; Sex Attractants / chemistry; Sex Attractants / genetics; Transcription Factors / genetics
TL;DR: Finding a single, large QTL that impacts variation in pheromone blends between and within species is the first such example for traits that have been demonstrated to affect premating isolation, and it is currently hypothesize that a transcription factor underlies this QTL. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2012 journal article

Molecular Markers Reveal Infestation Dynamics of the Bed Bug (Hemiptera: Cimicidae) Within Apartment Buildings

Journal of Medical Entomology, 49(3), 535–546.

By: W. Booth n, V. Saenz n, R. Santangelo n, C. Wang*, C. Schal n & E. Vargo n

author keywords: bed bug; microsatellite; population genetic structure; 454 pyrosequencing; inbreeding
MeSH headings : Animals; Cities; Hemiptera / genetics; Housing / statistics & numerical data; Microsatellite Repeats; New Jersey; North Carolina; Population Dynamics
TL;DR: Development of 24 high-resolution microsatellite markers through next generation 454 pyrosequencing and their application to elucidate infestation dynamics within three multistory apartment buildings in the United States are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2011 journal article

Unusual macrocyclic lactone sex pheromone of Parcoblatta lata, a primary food source of the endangered red-cockaded woodpecker

Proceedings of the National Academy of Sciences, 109(8), E490–E496.

By: D. Eliyahu n, S. Nojima n, R. Santangelo n, S. Carpenter*, F. Webster*, D. Kiemle*, C. Gemeno n, W. Leal*, C. Schal n

author keywords: pheromone monitoring; surveillance; wildlife conservation
MeSH headings : Animals; Arthropod Antennae / physiology; Birds / physiology; Chromatography, Gas; Cockroaches / metabolism; Endangered Species; Female; Food; Lactones / metabolism; Macrocyclic Compounds / metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Sex Attractants / analysis; Sex Attractants / chemistry
TL;DR: Parcoblattalactone was biologically active in electrophysiological assays and attracted not only P. lata but also several other Parcoblatta species in pine forests, underscoring its utility in monitoring several endemic wood cockroach species in red-cockaded woodpecker habitats. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Population Genetic Structure in German Cockroaches (Blattella Germanica): Differentiated Islands in an Agricultural Landscape

Journal of Heredity, 102(2), 175–183.

By: W. Booth n, R. Santangelo n, E. Vargo n, D. Mukha & C. Schal n

author keywords: Blattella germanica; commensal; Genetic bottleneck; human-mediated dispersal; microsatellite DNA profiling; population structure
MeSH headings : Agriculture; Animals; Bayes Theorem; Blattellidae / genetics; Genetic Variation; Genetics, Population; Genotype; Geography; Insect Control; Microsatellite Repeats / genetics; North Carolina; Phylogeny
TL;DR: Results reveal that structure of cockroach populations will be genetically structured based on association to a specific management company of origin, but instead it may be regional and influenced strongly by the unintentional movement of cockroaches by farm workers. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2010 journal article

Population genetic structure of the German cockroach (Blattodea: Blattellidae) in apartment buildings

Journal of Medical Entomology, 47(4), 553–564.

By: J. Crissman n, W. Booth n, R. Santangelo n, D. Mukha, E. Vargo n & C. Schal n

MeSH headings : Animals; Cockroaches / genetics; Genotype; Housing; Microsatellite Repeats; North Carolina; Phylogeny
UN Sustainable Development Goal Categories
11. Sustainable Cities and Communities (OpenAlex)
Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2010 journal article

Variation in Sexual Communication of the Tobacco Budworm, Heliothis virescens

SOUTHWESTERN ENTOMOLOGIST, 35(3), 367–372.

By: A. Groot*, C. Blanco*, A. Classen*, O. Inglis n, R. Santangelo n, J. Lopez*, D. Heckel*, C. Schal n

TL;DR: Results show that variation in Z9–14:Ald but not 16:A Ald is evolutionary significant and likely subject to stabilizing selection in the field. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 review

GEOGRAPHIC AND TEMPORAL VARIATION IN MOTH CHEMICAL COMMUNICATION

[Review of ]. EVOLUTION, 63(8), 1987–2003.

By: A. Groot n, O. Inglis n, S. Bowdridge n, R. Santangelo n, C. Blanco*, J. Lopez*, A. Teran Vargas*, F. Gould n, C. Schal n

Contributors: A. Groot n, O. Inglis n, S. Bowdridge n, R. Santangelo n, C. Blanco*, J. Lopez*, A. Vargas*, F. Gould n, C. Schal n

author keywords: Experience; female sex pheromone; Heliothis subflexa; Heliothis virescens; male response; phenotypic plasticity; selection
MeSH headings : Animal Communication; Animals; Female; Male; Mexico; Moths / chemistry; Moths / metabolism; Sex Attractants / chemistry; Sex Attractants / metabolism; United States
TL;DR: The pattern of temporal variation within populations suggests that optimization of the pheromonal signal also may be driven by within-generation physiological adjustments by the moths in response to their experience of the local chemical environment. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

QTL analysis of sex pheromone blend differences between two closely related moths: Insights into divergence in biosynthetic pathways

INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY, 39(8), 568–577.

By: A. Groot*, M. Estock n, J. Horovitz n, J. Hamilton n, R. Santangelo n, C. Schal n, F. Gould n

Contributors: A. Groot*, M. Estock n, J. Horovitz n, J. Hamilton n, R. Santangelo n, C. Schal n, F. Gould n

author keywords: Noctuidae; Heliothis virescens; Heliothis subflexa; Sex pheromone production; Biosynthetic pathway; Candidate genes
MeSH headings : Animals; Biosynthetic Pathways; Evolution, Molecular; Female; Insect Hormones / biosynthesis; Insect Hormones / genetics; Male; Moths / genetics; Moths / metabolism; Quantitative Trait Loci; Sex Attractants / biosynthesis; Sex Attractants / genetics
TL;DR: Quantitative Trait Locus analysis by hybridizing two noctuid moth species and backcrossing the F(1) females to males of both parental species reveals new QTL, which implicates several candidate genes in the divergence of these premating signals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Cockroach allergen reduction by cockroach control alone in low-income urban homes: A randomized control trial

Journal of Allergy and Clinical Immunology, 120(4), 849–855.

By: M. Sever*, S. Arbes, J. Gore, R. Santangelo*, B. Vaughn, H. Mitchell, C. Schal*, D. Zeldin

Contributors: M. Sever*, S. Arbes, J. Gore*, R. Santangelo*, B. Vaughn, H. Mitchell, C. Schal*, D. Zeldin

author keywords: cockroaches; cockroach allergen; Bla g 1; Bla g 2; indoor allergens; intervention trial
MeSH headings : Allergens / analysis; Animals; Antigens, Plant; Cockroaches / immunology; Costs and Cost Analysis; Income; Insect Control / economics; Urban Population
TL;DR: Reductions in Bla g 1 in cockroach-infested homes can be achieved by reducing infestations; however, the magnitude of allergen reduction is dependent on the thoroughness and effectiveness of cockroach eradication efforts. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

Differential attraction of Heliothis subflexa males to synthetic pheromone lures in eastern US and western Mexico

JOURNAL OF CHEMICAL ECOLOGY, 33(2), 353–368.

By: A. Groot n, R. Santangelo n, E. Ricci n, C. Brownie n, F. Gould n & C. Schal n

author keywords: sexual communication; pheromone; pheromone component; geographic variation; acetate esters; 16-carbon alcohol; 14-carbon aldehydes; dose-response; minimal blend; complete blend
MeSH headings : Acetates / chemistry; Animal Communication; Animals; Dose-Response Relationship, Drug; Male; Mexico; Moths; Sex Attractants / chemical synthesis; Sex Attractants / chemistry; Sex Attractants / pharmacology; Sexual Behavior, Animal; United States
TL;DR: The mate attraction signal of Heliothis subflexa (Hs) females consists of a multicomponent sex pheromone blend, and it is indicated that the addition of Z9-16:OAc alone does not increase attraction of male Hs, while Z11-16-OAc does. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Experimental evidence for interspecific directional selection on moth pheromone communication

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103(15), 5858–5863.

By: A. Groot n, J. Horovitz n, J. Hamilton n, R. Santangelo n, C. Schal n & F. Gould n

Contributors: A. Groot n, J. Horovitz n, J. Hamilton n, R. Santangelo n, C. Schal n & F. Gould n

author keywords: communication interference; Helicithis subflexa; Heliothis virescens; sexual communication; speciation
MeSH headings : Animals; Female; Genotype; Male; Moths / genetics; Moths / physiology; Phenotype; Pheromones / physiology; Regression Analysis; Sexual Behavior, Animal
TL;DR: It is quantitatively estimate that the directional selection exerted by Hv males on Hs females to produce relatively high amounts of acetates can range from 0.135 to 0.231, which may counteract intraspecific stabilizing selection that impedes evolutionary changes in pheromone blends and could lead to diversification of sexual signals. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Introgressing pheromone QTL between species: Towards an evolutionary understanding of differentiation in sexual communication

Journal of Chemical Ecology, 30(12), 2495–2514.

By: A. Groot n, C. Ward n, J. Wang n, A. Pokrzywa n, J. O’Brien n, J. Bennett n, J. Kelly n, R. Santangelo n, C. Schal n, F. Gould n

author keywords: Heliothis virescens; Heliothis subflexa; multi-component sex pheromone blend; QTL; quantitative trait loci; backcross; AFLP; amplified fragment length polymorphism; phenotype; genotype
MeSH headings : Animal Communication; Animals; Chromosome Mapping; Female; Genomics; Male; Moths / physiology; Pheromones / physiology; Quantitative Trait Loci / genetics; Quantitative Trait Loci / physiology; Sex Attractants / chemistry; Sex Attractants / physiology; Sexual Behavior, Animal / physiology
TL;DR: The introgressed Hv-chromosome 22 into the genomic background of Hs, isolating the chromosome that has a major effect on acetate production and can be tested in behavioral experiments whether the presence of acetates may have been a driving force for a shift in pheromone composition. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2004 journal article

Water solutions of boric acid and sugar for management of German cockroach populations in livestock production systems

JOURNAL OF ECONOMIC ENTOMOLOGY, 97(2), 715–720.

By: J. Gore*, L. Zurek*, R. Santangelo*, S. Stringham*, D. Watson & C. Schal*

UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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