Robert J. Langenbach

Works (3)

Updated: July 5th, 2023 16:02

2012 journal article

Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages

Particle and Fibre Toxicology, 9.

By: J. Lee, B. Sayers, K. Chun, H. Lao, J. Shipley-Phillips, J. Bonner , R. Langenbach

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytes

MOLECULAR PHARMACOLOGY, 59(4), 860–866.

By: H. Wang n, M. Kim  n, H. Tiano n, R. Langenbach n & R. Smart n 

MeSH headings : Animals; Arachidonic Acid / metabolism; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cells, Cultured; Cyclooxygenase 2; Cytosol / enzymology; Dinoprostone / metabolism; Enzyme Inhibitors / pharmacology; Inflammation / metabolism; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratins / genetics; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Phospholipases A / metabolism; Phospholipids / metabolism; Phosphorylation / drug effects; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases / biosynthesis; Protein Isoforms / genetics; Protein Kinase C / antagonists & inhibitors; Protein Kinase C / genetics; Protein Kinase C / metabolism; Protein Kinase C-alpha; Signal Transduction / drug effects; Signal Transduction / physiology; Skin / drug effects; Skin / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: It is indicated that epidermal PKC alpha coordinately regulates cPLA(2) activity and COX-2 expression resulting in increased levels of AA and PGE(2), and MEK-dependent and C/EBP beta-independent events. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

JOURNAL OF CLINICAL INVESTIGATION, 105(4), 469–478.

By: O. Morteau*, S. Morham, R. Sellon n, L. Dieleman, R. Langenbach*, O. Smithies, R. Sartor*

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Colitis / chemically induced; Colitis / mortality; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Dextrans / pharmacology; Dinoprostone / metabolism; Interleukin-1 / metabolism; Intestinal Mucosa / pathology; Isoenzymes / antagonists & inhibitors; Isoenzymes / deficiency; Isoenzymes / genetics; Isoenzymes / pharmacology; Membrane Proteins; Mice; Mice, Mutant Strains; Nitrobenzenes / pharmacology; Prostaglandin-Endoperoxide Synthases / deficiency; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / pharmacology; Sulfates / pharmacology; Sulfonamides / pharmacology
TL;DR: COX-1 and COX-2 share a crucial role in the defense of the intestinal mucosa (with inducible COX -2 being perhaps more active during inflammation) and that neither isoform is essential in maintaining mucosal homeostasis in the absence of injurious stimuli. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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