Robert J. Langenbach

Works (3)

Updated: July 5th, 2023 16:02

2012 journal article

Multi-walled carbon nanotubes induce COX-2 and iNOS expression via MAP Kinase-dependent and -independent mechanisms in mouse RAW264.7 macrophages

Particle and Fibre Toxicology, 9.

By: J. Lee, B. Sayers, K. Chun, H. Lao, J. Shipley-Phillips, J. Bonner , R. Langenbach

Source: NC State University Libraries
Added: August 6, 2018

2001 journal article

Protein kinase C-alpha coordinately regulates cytosolic phospholipase A(2) activity and the expression of cyclooxygenase-2 through different mechanisms in mouse keratinocytes

MOLECULAR PHARMACOLOGY, 59(4), 860–866.

By: H. Wang n, M. Kim  n, H. Tiano n, R. Langenbach n & R. Smart n 

MeSH headings : Animals; Arachidonic Acid / metabolism; CCAAT-Enhancer-Binding Protein-beta / metabolism; Cells, Cultured; Cyclooxygenase 2; Cytosol / enzymology; Dinoprostone / metabolism; Enzyme Inhibitors / pharmacology; Inflammation / metabolism; Isoenzymes / antagonists & inhibitors; Isoenzymes / biosynthesis; Isoenzymes / genetics; Isoenzymes / metabolism; Keratinocytes / cytology; Keratinocytes / drug effects; Keratinocytes / metabolism; Keratins / genetics; Mice; Mice, Transgenic; Mitogen-Activated Protein Kinase Kinases / antagonists & inhibitors; Phospholipases A / metabolism; Phospholipids / metabolism; Phosphorylation / drug effects; Promoter Regions, Genetic; Prostaglandin-Endoperoxide Synthases / biosynthesis; Protein Isoforms / genetics; Protein Kinase C / antagonists & inhibitors; Protein Kinase C / genetics; Protein Kinase C / metabolism; Protein Kinase C-alpha; Signal Transduction / drug effects; Signal Transduction / physiology; Skin / drug effects; Skin / metabolism; Tetradecanoylphorbol Acetate / pharmacology
TL;DR: It is indicated that epidermal PKC alpha coordinately regulates cPLA(2) activity and COX-2 expression resulting in increased levels of AA and PGE(2), and MEK-dependent and C/EBP beta-independent events. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2

JOURNAL OF CLINICAL INVESTIGATION, 105(4), 469–478.

By: O. Morteau*, S. Morham, R. Sellon n, L. Dieleman, R. Langenbach*, O. Smithies, R. Sartor*

MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / pharmacology; Colitis / chemically induced; Colitis / mortality; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors / pharmacology; Dextrans / pharmacology; Dinoprostone / metabolism; Interleukin-1 / metabolism; Intestinal Mucosa / pathology; Isoenzymes / antagonists & inhibitors; Isoenzymes / deficiency; Isoenzymes / genetics; Isoenzymes / pharmacology; Membrane Proteins; Mice; Mice, Mutant Strains; Nitrobenzenes / pharmacology; Prostaglandin-Endoperoxide Synthases / deficiency; Prostaglandin-Endoperoxide Synthases / genetics; Prostaglandin-Endoperoxide Synthases / pharmacology; Sulfates / pharmacology; Sulfonamides / pharmacology
TL;DR: COX-1 and COX-2 share a crucial role in the defense of the intestinal mucosa (with inducible COX -2 being perhaps more active during inflammation) and that neither isoform is essential in maintaining mucosal homeostasis in the absence of injurious stimuli. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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