Rebecca J. Linger

Works (6)

Updated: July 30th, 2023 21:14

2018 journal article

Towards next generation maggot debridement therapy: Transgenic Lucilia sericata larvae that produce and secrete a human growth factor

Wound Repair and Regeneration, 26(1), A27–27.

By: R. Davis, E. Belikoff & M. Scott 

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Building early-larval sexing systems for genetic control of the Australian sheep blow fly Lucilia cuprina using two constitutive promoters

Scientific Reports, 7(1).

By: Y. Yan n, R. Linger n & M. Scott n 

MeSH headings : Animals; Animals, Genetically Modified; Australia; Diptera / genetics; Diptera / growth & development; Diptera / metabolism; Embryo, Nonmammalian; Female; Genes, Insect; Genes, Lethal; Larva / genetics; Larva / growth & development; Larva / metabolism; Male; Pest Control, Biological / methods; Promoter Regions, Genetic; Sex Differentiation; Sheep / parasitology; Sheep Diseases / prevention & control; Tetracycline / pharmacology; Transcriptional Activation / drug effects
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Insect behavior and control techniques; CRISPR and Genetic Engineering
TL;DR: Investigating the idea of isolating and employing the promoters from the Lucilia spitting image and actin 5C genes to drive tTA expression in embryos and later stages found it to be effective for assembling an effective TSS. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Towards next generation maggot debridement therapy: transgenic Lucilia sericata larvae that produce and secrete a human growth factor

BMC Biotechnology, 16(1).

By: R. Linger n, E. Belikoff n, Y. Yan n, F. Li n, H. Wantuch  n, H. Fitzsimons *, M. Scott n 

author keywords: Maggot debridement therapy (MDT); Platelet-derived growth factor (PDGF); Excretions/secretions (ES); Growth factor treatment; Diabetic foot ulcer; Tetracycline transactivator; Lucilia sericata; Wound healing
topics (OpenAlex): Forensic Entomology and Diptera Studies; Insect Utilization and Effects; Insect and Pesticide Research
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Dosage Compensation of X-Linked Muller Element F Genes but Not X-Linked Transgenes in the Australian Sheep Blowfly

PLOS ONE, 10(10), e0141544.

By: R. Linger n, E. Belikoff n & M. Scott n 

Ed(s): G. Marais

MeSH headings : Animals; Animals, Genetically Modified; Diptera / genetics; Dosage Compensation, Genetic; Drosophila melanogaster / genetics; Female; Gene Expression Regulation, Developmental; Genes, X-Linked / genetics; Larva; Male; X Chromosome / genetics
topics (OpenAlex): Insect Resistance and Genetics; CRISPR and Genetic Engineering; Insect symbiosis and bacterial influences
TL;DR: It appears that the Lucilia dosage compensation system is specific for genes endogenous to the X chromosome and cannot be co-opted by recently arrived transgenes. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Functional characterization of calliphorid cell death genes and cellularization gene promoters for controlling gene expression and cell viability in early embryos

Insect Molecular Biology, 24(1), 58–70.

By: R. Edman n, R. Linger n, E. Belikoff n, F. Li n, S. Sze*, A. Tarone *, M. Scott n 

author keywords: genetic sexing; transgenic; cellularization gene; sterile insect technique
MeSH headings : Amino Acid Sequence; Animals; Animals, Genetically Modified; Base Sequence; Cell Death / genetics; Cell Survival; Diptera / embryology; Diptera / genetics; Diptera / growth & development; Drosophila melanogaster / genetics; Drosophila melanogaster / growth & development; Embryo, Nonmammalian; Female; Gene Expression Regulation; Genes, Insect; Genes, Lethal; Male; Molecular Sequence Data; Pest Control, Biological / methods; Promoter Regions, Genetic; Sex Ratio
topics (OpenAlex): Insect Resistance and Genetics; Viral Infectious Diseases and Gene Expression in Insects; Insect behavior and control techniques
TL;DR: The isolated gene promoters and pro‐apoptotic genes could potentially be used to build transgenic embryonic sexing strains of calliphorid livestock pests. (via Semantic Scholar)
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Sources: Web Of Science, Crossref
Added: August 6, 2018

2014 journal article

Transgenic sexing system for genetic control of the Australian sheep blow fly Lucilia cuprina

Insect Biochemistry and Molecular Biology, 51, 80–88.

By: F. Li n, H. Wantuch  n, R. Linger n, E. Belikoff n & M. Scott n 

author keywords: Sterile insect technique; Transgenic; Lucilia cuprina; Flystrike; Genetic sexing
MeSH headings : Animals; Animals, Genetically Modified; Diptera / genetics; Female; Genes, Insect; Genes, Lethal; Male; Pest Control, Biological / methods; Sex Determination Processes
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Insect behavior and control techniques; Forensic Entomology and Diptera Studies
TL;DR: Transgenic strains of L. cuprina that carry a dominant tetracycline repressible female lethal genetic system are developed and should be readily transferrable to other major calliphorid livestock pests including the New and Old World screwworm. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, Crossref, NC State University Libraries
Added: August 6, 2018

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