2019 journal article
2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain
SCIENTIFIC REPORTS, 9.
2019 journal article
Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold
CHEMMEDCHEM, 14(9), 927–937.
2019 journal article
Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii
ACS INFECTIOUS DISEASES, 5(7), 1223–1230.
2019 journal article
Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation
MEDCHEMCOMM, 10(3), 456–459.
2018 journal article
Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.
FRONTIERS IN MOLECULAR BIOSCIENCES, 5.
2018 journal article
Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa
ACS INFECTIOUS DISEASES, 5(1), 141–151.
2017 journal article
2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability
PLoS One, 12(7).
2017 review
Narrow-spectrum antibacterial agents
[Review of ]. MEDCHEMCOMM, 9(1), 12–21.
2017 journal article
Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display
BIOCONJUGATE CHEMISTRY, 28(7), 1807–1810.
2017 journal article
Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria
BIOORGANIC & MEDICINAL CHEMISTRY, 25(20), 5749–5753.
2017 journal article
Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds
MOLECULAR MICROBIOLOGY, 106(2), 223–235.
2017 article
The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?
Melander, R. J., & Melander, C. (2017, August). ACS INFECTIOUS DISEASES, Vol. 3, pp. 559–563.
2017 journal article
The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(14), 3940–3944.
2016 journal article
Marine sponge alkaloids as a source of anti-bacterial adjuvants
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26(24), 5863–5866.
2015 article
From Worms to Targeting Virulence Factors
Melander, R. J., & Melander, C. (2015, April 23). CHEMISTRY & BIOLOGY, Vol. 22, pp. 436–437.
2015 journal article
Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives
TETRAHEDRON LETTERS, 56(23), 3406–3409.
2015 journal article
Innovative strategies for combating biofilm-based infections
Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91.
2015 journal article
Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants
MEDCHEMCOMM, 7(1), 128–131.
2015 journal article
Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4820–4823.
2015 journal article
Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity
TETRAHEDRON, 72(25), 3549–3553.
2014 journal article
Controlling bacterial behavior with indole-containing natural products and derivatives
TETRAHEDRON, 70(37), 6363–6372.
2014 journal article
Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors
MOLECULAR ORAL MICROBIOLOGY, 29(5), 185–193.
2014 journal article
Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules
PATHOGENS AND DISEASE, 70(3), 370–378.
2014 article
Small Steps to New Drugs for Bugs
Melander, R. J., & Selwood, D. L. (2015, January). CHEMICAL BIOLOGY & DRUG DESIGN, Vol. 85, pp. 1–3.
2014 journal article
Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens
JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458.
2014 journal article
Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis
CHEMICAL COMMUNICATIONS, 50(100), 15860–15863.
2013 journal article
Biologically inspired strategies for combating bacterial biofilms
CURRENT OPINION IN PHARMACOLOGY, 13(5), 699–706.
2013 review
Combination approaches to combat multidrug-resistant bacteria
[Review of ]. TRENDS IN BIOTECHNOLOGY, 31(3), 177–184.
2013 journal article
Overcoming Resistance to beta-Lactam Antibiotics
JOURNAL OF ORGANIC CHEMISTRY, 78(9), 4207–4213.
2013 journal article
Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance
ACS CHEMICAL BIOLOGY, 9(1), 122–127.
2013 review
Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence
[Review of ]. FUTURE MEDICINAL CHEMISTRY, 5(11), 1265–1284.
2012 journal article
2-Aminopyrimidine as a novel scaffold for biofilm modulation
Organic & Biomolecular Chemistry, 10(13), 2552–2561.
2012 journal article
Deconvoluting Interspecies Bacterial Communication
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(26), 6314–6315.
2012 journal article
Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper
PLANT DISEASE, 96(11), 1638–1644.
2012 journal article
N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization
ORGANIC & BIOMOLECULAR CHEMISTRY, 11(1), 130–137.
2012 journal article
Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(45), 11254–11257.
2012 journal article
Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae
ACS MEDICINAL CHEMISTRY LETTERS, 3(5), 357–361.
2012 journal article
Small molecule control of bacterial biofilms
Organic & Biomolecular Chemistry, 10(37), 7457–7474.
2011 journal article
A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(15), 4516–4519.
2011 journal article
Evaluation of 4,5-Disubstituted-2-Aminoimidazole-Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii
CHEMMEDCHEM, 6(12), 2243–2251.
2011 journal article
Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA
CHEMICAL BIOLOGY & DRUG DESIGN, 79(1), 9–21.
2011 journal article
Intercepting Bacterial Indole Signaling with Flustramine Derivatives
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160–20163.
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