Roberta J. Worthington Melander

Works (42)

2019 journal article

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

SCIENTIFIC REPORTS, 9.

By: A. Jeon, D. Ackart, W. Li, M. Jackson, R. Melander, C. Melander, R. Abramovitch, A. Chicco, R. Basaraba, A. Obregon-Henao

Source: NC State University Libraries
Added: February 25, 2019

2019 journal article

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

CHEMMEDCHEM, 14(9), 927–937.

By: T. Nguyen, B. Minrovic, R. Melander & C. Melander

Source: Web Of Science
Added: July 1, 2019

2019 journal article

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

ACS INFECTIOUS DISEASES, 5(7), 1223–1230.

By: S. Martin, R. Melander, C. Brackett, A. Scott, C. Chandler, C. Nguyen, B. Minrovic, S. Harrill ...

Source: Web Of Science
Added: August 5, 2019

2019 journal article

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

MEDCHEMCOMM, 10(3), 456–459.

By: T. Nguyen, M. Peszko, R. Melander & C. Melander

Source: Web Of Science
Added: April 22, 2019

2019 journal article

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

ACS INFECTIOUS DISEASES, 5(1), 141–151.

By: V. Hubble, B. Hubbard, B. Minrovic, R. Melander & C. Melander

Source: Web Of Science
Added: April 20, 2020

2018 review

Narrow-spectrum antibacterial agents

[Review of ]. MedChemComm, 9(1), 12–21.

By: R. Melander, D. Zurawski & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

FRONTIERS IN MOLECULAR BIOSCIENCES, 5.

By: M. Milton, B. Minrovic, D. Harris, B. Kang, D. Jung, C. Lewis, R. Thompson, R. Melander ...

Source: NC State University Libraries
Added: January 28, 2019

2017 journal article

2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability

PLoS One, 12(7).

By: A. Jeon, A. Obregon-Henao, D. Ackart, B. Podell, J. Belardinelli, M. Jackson, T. Nguyen, M. Blackledge ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Probing the mechanism of LAL-32, a gold nanoparticle-based antibiotic discovered through small molecule variable ligand display

Bioconjugate Chemistry, 28(7), 1807–1810.

By: R. Byrne-Nash, D. Lucero, N. Osbaugh, R. Melander, C. Melander & D. Feldheim

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

Bioorganic & Medicinal Chemistry, 25(20), 5749–5753.

By: W. Barker, S. Martin, C. Chandler, T. Nguyen, T. Harris, C. Goodell, R. Melander, Y. Doi, R. Ernst, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

Molecular Microbiology, 106(2), 223–235.

By: M. Milton, C. Allen, E. Feldmann, B. Bobay, D. Jung, M. Stephens, R. Melander, K. Theisen ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

The challenge of overcoming antibiotic resistance: An adjuvant approach?

ACS Infectious Diseases, 3(8), 559–563.

By: R. Melander & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

The discovery of 2-aminobenzimidazoles that sensitize mycobacterium smegmatis and m. tuberculosis to beta-lactam antibiotics in a pattern distinct from beta-lactamase inhibitors

Angewandte Chemie [International Edition in English], 56(14), 3940–3944.

By: T. Nguyen, M. Blackledge, E. Lindsey, B. Minrovic, D. Ackart, A. Jeon, A. Obregon-Henao, R. Melander, R. Basaraba, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Marine sponge alkaloids as a source of anti-bacterial adjuvants

Bioorganic & Medicinal Chemistry Letters, 26(24), 5863–5866.

By: R. Melander, H. Liu, M. Stephens, C. Bewley & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MedChemComm, 7(1), 128–131.

By: M. Stephens, V. Hubble, R. Ernst, M. Hoek, R. Melander, J. Cavanagh, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

Tetrahedron, 72(25), 3549–3553.

By: C. Brackett, R. Furlani, R. Anderson, A. Krishnamurthy, R. Melander, S. Moskowitz, R. Ernst, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

From worms to targeting virulence factors

Chemistry & Biology, 22(4), 436–437.

By: R. Melander & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

Tetrahedron Letters, 56(23), 3406–3409.

By: M. Richardson, R. Furlani, B. Podell, D. Ackart, J. Haugen, R. Melander, C. Melander, R. Basaraba

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Innovative strategies for combating biofilm-based infections

Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91.

By: R. Melander & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

Bioorganic & Medicinal Chemistry Letters, 25(21), 4820–4823.

By: R. Furlani, M. Richardson, B. Podell, D. Ackart, J. Haugen, R. Melander, R. Basaraba, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Small steps to new drugs for bugs

Chemical Biology & Drug Design, 85(1), 1–3.

By: R. Melander & D. Selwood

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Controlling bacterial behavior with indole-containing natural products and derivatives

Tetrahedron, 70(37), 6363–6372.

By: R. Melander, M. Minvielle & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors

Molecular Oral Microbiology, 29(5), 185–193.

By: C. Wright, H. Wu, R. Melander, C. Melander & J. Lamont

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules

Pathogens and Disease, 70(3), 370–378.

By: D. Ackart, E. Lindsey, B. Podell, R. Melander, R. Basaraba & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance

ACS Chemical Biology, 9(1), 122–127.

By: T. Harris, R. Worthington, L. Hittle, D. Zurawski, R. Ernst & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Small-molecule suppression of beta-lactam resistance in multidrug-resistant gram-negative pathogens

Journal of Medicinal Chemistry, 57(17), 7450–7458.

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

Chemical Communications, 50(100), 15860–15863.

By: J. Gifford, J. Bresee, C. Carter, G. Wang, R. Melander, C. Melander, D. Feldheim

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Biologically inspired strategies for combating bacterial biofilms

Current Opinion in Pharmacology, 13(5), 699–706.

By: M. Blackledge, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 review

Combination approaches to combat multidrug-resistant bacteria

[Review of ]. Trends in Biotechnology, 31(3), 177–184.

By: R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

Organic & Biomolecular Chemistry, 11(1), 130–137.

By: A. Yeagley, Z. Su, K. McCullough, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Overcoming resistance to beta-lactam antibiotics

Journal of Organic Chemistry, 78(9), 4207–4213.

By: R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 review

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

[Review of ]. Future medicinal chemistry, 5(11), 1265–1284.

By: R. Worthington, M. Blackledge & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

2-Aminopyrimidine as a novel scaffold for biofilm modulation

Organic & Biomolecular Chemistry, 10(13), 2552–2561.

By: E. Lindsey, R. Worthington, C. Alcaraz & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Deconvoluting interspecies bacterial communication

Angewandte Chemie [International Edition in English], 51(26), 6314–6315.

By: R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Exploring the interaction between siRNA and the SMoC biomolecule transporters: Implications for small molecule-mediated delivery of siRNA

Chemical Biology & Drug Design, 79(1), 9–21.

By: M. Gooding, S. Tudzarova, R. Worthington, S. Kingsbury, A. Rebstock, H. Dube, M. Simone, C. Visintin ...

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Foliar-applied small molecule that suppresses biofilm formation and enhances control of copper-resistant Xanthomonas euvesicatoria on pepper

Plant Disease, 96(11), 1638–1644.

By: R. Worthington, S. Rogers, R. Huigens, C. Melander & D. Ritchie

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus

Angewandte Chemie [International Edition in English], 51(45), 11254–11257.

By: T. Harris, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Small molecule control of bacterial biofilms

Organic & Biomolecular Chemistry, 10(37), 7457–7474.

By: R. Worthington, J. Richards & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae

ACS Medicinal Chemistry Letters, 3(5), 357–361.

By: R. Worthington, C. Bunders, C. Reed & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

Bioorganic & Medicinal Chemistry Letters, 21(15), 4516–4519.

By: T. Harris, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii

Chemmedchem, 6(12), 2243–2251.

By: Z. Su, L. Peng, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Intercepting bacterial indole signaling with flustramine derivatives

Journal of the American Chemical Society, 133(50), 20160–20163.

By: C. Bunders, M. Minvielle, R. Worthington, M. Ortiz, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018