Roberta J. Worthington Melander Jeon, A. B., Ackart, D. F., Li, W., Jackson, M., Melander, R. J., Melander, C., … Obregon-Henao, A. (2019). 2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain. SCIENTIFIC REPORTS, 9. https://doi.org/10.1038/s41598-018-38064-7 Nguyen, T. V., Minrovic, B. M., Melander, R. J., & Melander, C. (2019). Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold. CHEMMEDCHEM, 14(9), 927–937. https://doi.org/10.1002/cmdc.201900033 Martin, S. E., Melander, R. J., Brackett, C. M., Scott, A. J., Chandler, C. E., Nguyen, C. M., … Melander, C. (2019). Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii. ACS INFECTIOUS DISEASES, 5(7), 1223–1230. https://doi.org/10.1021/acsinfecdis.9b00067 Nguyen, T. V., Peszko, M. T., Melander, R. J., & Melander, C. (2019). Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation. MEDCHEMCOMM, 10(3), 456–459. https://doi.org/10.1039/c9md00025a Hubble, V. B., Hubbard, B. A., Minrovic, B. M., Melander, R. J., & Melander, C. (2019). Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa. ACS INFECTIOUS DISEASES, 5(1), 141–151. https://doi.org/10.1021/acsinfecdis.8b00288 Melander, R. J., Zurawski, D. V., & Melander, C. (2018). [Review of Narrow-spectrum antibacterial agents]. MEDCHEMCOMM, 9(1), 12–21. https://doi.org/10.1039/c7md00528h Milton, M. E., Minrovic, B. M., Harris, D. L., Kang, B., Jung, D., Lewis, C. P., … Cavanagh, J. (2018). Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp. FRONTIERS IN MOLECULAR BIOSCIENCES, 5. https://doi.org/10.3389/fmolb.2018.00015 Jeon, A. B., Obregon-Henao, A., Ackart, D. F., Podell, B. K., Belardinelli, J. M., Jackson, M., … Basaraba, R. J. (2017). 2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability. PLoS One, 12(7). Byrne-Nash, R., Lucero, D. M., Osbaugh, N. A., Melander, R. J., Melander, C., & Feldheim, D. L. (2017). Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display. BIOCONJUGATE CHEMISTRY, 28(7), 1807–1810. https://doi.org/10.1021/acs.bioconjchem.7b00199 Barker, W. T., Martin, S. E., Chandler, C. E., Nguyen, T. V., Harris, T. L., Goodell, C., … Melander, C. (2017). Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria. BIOORGANIC & MEDICINAL CHEMISTRY, 25(20), 5749–5753. https://doi.org/10.1016/j.bmc.2017.08.055 Milton, M. E., Allen, C. L., Feldmann, E. A., Bobay, B. G., Jung, D. K., Stephens, M. D., … Cavanagh, J. (2017). Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. MOLECULAR MICROBIOLOGY, 106(2), 223–235. https://doi.org/10.1111/mmi.13759 Melander, R. J., & Melander, C. (2017, August). The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach? ACS INFECTIOUS DISEASES, Vol. 3, pp. 559–563. https://doi.org/10.1021/acsinfecdis.7b00071 Nguyen, T. V., Blackledge, M. S., Lindsey, E. A., Minrovic, B. M., Ackart, D. F., Jeon, A. B., … Melander, C. (2017). The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(14), 3940–3944. https://doi.org/10.1002/anie.201612006 Melander, R. J., Liu, H.-bing, Stephens, M. D., Bewley, C. A., & Melander, C. (2016). Marine sponge alkaloids as a source of anti-bacterial adjuvants. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26(24), 5863–5866. https://doi.org/10.1016/j.bmcl.2016.11.018 Stephens, M. D., Hubble, V. B., Ernst, R. K., Hoek, M. L., Melander, R. J., Cavanagh, J., & Melander, C. (2016). Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants. MEDCHEMCOMM, 7(1), 128–131. https://doi.org/10.1039/c5md00353a Brackett, C. M., Furlani, R. E., Anderson, R. G., Krishnamurthy, A., Melander, R. J., Moskowitz, S. M., … Melander, C. (2016). Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity. TETRAHEDRON, 72(25), 3549–3553. https://doi.org/10.1016/j.tet.2015.09.019 Melander, R. J., & Melander, C. (2015, April 23). From Worms to Targeting Virulence Factors. CHEMISTRY & BIOLOGY, Vol. 22, pp. 436–437. https://doi.org/10.1016/j.chembiol.2015.04.005 Richardson, M. A., Furlani, R. E., Podell, B. K., Ackart, D. F., Haugen, J. D., Melander, R. J., … Basaraba, R. J. (2015). Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives. TETRAHEDRON LETTERS, 56(23), 3406–3409. https://doi.org/10.1016/j.tetlet.2015.01.122 Melander, R. J., & Melander, C. (2015). Innovative strategies for combating biofilm-based infections. Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91. Furlani, R. E., Richardson, M. A., Podell, B. K., Ackart, D. F., Haugen, J. D., Melander, R. J., … Melander, C. (2015). Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4820–4823. https://doi.org/10.1016/j.bmcl.2015.06.080 Melander, R. J., & Selwood, D. L. (2015, January). Small Steps to New Drugs for Bugs. CHEMICAL BIOLOGY & DRUG DESIGN, Vol. 85, pp. 1–3. https://doi.org/10.1111/cbdd.12482 Melander, R. J., Minvielle, M. J., & Melander, C. (2014). Controlling bacterial behavior with indole-containing natural products and derivatives. TETRAHEDRON, 70(37), 6363–6372. https://doi.org/10.1016/j.tet.2014.05.089 Wright, C. J., Wu, H., Melander, R. J., Melander, C., & Lamont, J. (2014). Disruption of heterotypic community development by Porphyromonas gingivalis with small molecule inhibitors. MOLECULAR ORAL MICROBIOLOGY, 29(5), 185–193. https://doi.org/10.1111/omi.12060 Ackart, D. F., Lindsey, E. A., Podell, B. K., Melander, R. J., Basaraba, R. J., & Melander, C. (2014). Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules. PATHOGENS AND DISEASE, 70(3), 370–378. https://doi.org/10.1111/2049-632x.12143 Harris, T. L., Worthington, R. J., Hittle, L. E., Zurawski, D. V., Ernst, R. K., & Melander, C. (2014). Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance. ACS CHEMICAL BIOLOGY, 9(1), 122–127. https://doi.org/10.1021/cb400490k Brackett, C. M., Melander, R. J., An, I. H., Krishnamurthy, A., Thompson, R. J., Cavanagh, J., & Melander, C. (2014). Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens. JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458. https://doi.org/10.1021/jm501050e Gifford, J. C., Bresee, J., Carter, C. J., Wang, G., Melander, R. J., Melander, C., & Feldheim, D. L. (2014). Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis. CHEMICAL COMMUNICATIONS, 50(100), 15860–15863. https://doi.org/10.1039/c4cc06236a Blackledge, M. S., Worthington, R. J., & Melander, C. (2013). Biologically inspired strategies for combating bacterial biofilms. CURRENT OPINION IN PHARMACOLOGY, 13(5), 699–706. https://doi.org/10.1016/j.coph.2013.07.004 Worthington, R. J., & Melander, C. (2013). [Review of Combination approaches to combat multidrug-resistant bacteria]. TRENDS IN BIOTECHNOLOGY, 31(3), 177–184. https://doi.org/10.1016/j.tibtech.2012.12.006 Yeagley, A. A., Su, Z., McCullough, K. D., Worthington, R. J., & Melander, C. (2013). N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization. ORGANIC & BIOMOLECULAR CHEMISTRY, 11(1), 130–137. https://doi.org/10.1039/c2ob26469b Worthington, R. J., & Melander, C. (2013). Overcoming Resistance to beta-Lactam Antibiotics. JOURNAL OF ORGANIC CHEMISTRY, 78(9), 4207–4213. https://doi.org/10.1021/jo400236f Worthington, R. J., Blackledge, M. S., & Melander, C. (2013). [Review of Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence]. FUTURE MEDICINAL CHEMISTRY, 5(11), 1265–1284. https://doi.org/10.4155/fmc.13.58 Lindsey, E. A., Worthington, R. J., Alcaraz, C., & Melander, C. (2012). 2-Aminopyrimidine as a novel scaffold for biofilm modulation. Organic & Biomolecular Chemistry, 10(13), 2552–2561. Worthington, R. J., & Melander, C. (2012). Deconvoluting Interspecies Bacterial Communication. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(26), 6314–6315. https://doi.org/10.1002/anie.201202440 Gooding, M., Tudzarova, S., Worthington, R. J., Kingsbury, S. R., Rebstock, A.-S., Dube, H., … Selwood, D. L. (2012). Exploring the Interaction Between siRNA and the SMoC Biomolecule Transporters: Implications for Small Molecule-Mediated Delivery of siRNA. CHEMICAL BIOLOGY & DRUG DESIGN, 79(1), 9–21. https://doi.org/10.1111/j.1747-0285.2011.01249.x Worthington, R. J., Rogers, S. A., Huigens, R. W., III, Melander, C., & Ritchie, D. F. (2012). Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper. PLANT DISEASE, 96(11), 1638–1644. https://doi.org/10.1094/pdis-02-12-0190-re Harris, T. L., Worthington, R. J., & Melander, C. (2012). Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(45), 11254–11257. https://doi.org/10.1002/anie.201206911 Worthington, R. J., Bunders, C. A., Reed, C. S., & Melander, C. (2012). Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae. ACS MEDICINAL CHEMISTRY LETTERS, 3(5), 357–361. https://doi.org/10.1021/ml200290p Worthington, R. J., Richards, J. J., & Melander, C. (2012). Small molecule control of bacterial biofilms. Organic & Biomolecular Chemistry, 10(37), 7457–7474. Harris, T. L., Worthington, R. J., & Melander, C. (2011). A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(15), 4516–4519. https://doi.org/10.1016/j.bmcl.2011.05.123 Su, Z., Peng, L., Worthington, R. J., & Melander, C. (2011). Evaluation of 4,5-Disubstituted-2-Aminoimidazole-Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii. CHEMMEDCHEM, 6(12), 2243–2251. https://doi.org/10.1002/cmdc.201100316 Bunders, C. A., Minvielle, M. J., Worthington, R. J., Ortiz, M., Cavanagh, J., & Melander, C. (2011). Intercepting Bacterial Indole Signaling with Flustramine Derivatives. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160–20163. https://doi.org/10.1021/ja209836z