Works (10)

Updated: August 17th, 2023 21:16

2021 journal article

Autocrine and paracrine interferon signalling as 'ring vaccination' and 'contact tracing' strategies to suppress virus infection in a host

By: G. Lavigne n, H. Russellโ€‰ n, B. Sherry n & R. Ke n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: interferon; innate immunity; ring vaccination; partial differential equations; cellular automata
MeSH headings : Antiviral Agents; Contact Tracing; Humans; Immunity, Innate; Interferons; Vaccination; Virus Diseases
Source: Web Of Science
Added: April 5, 2021

2019 journal article

Principles of Effective and Robust Innate Immune Response to Viral Infections: A Multiplex Network Analysis

FRONTIERS IN IMMUNOLOGY, 10.

By: Y. Huang n, H. Dai nโ€‰ & R. Ke n

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: immune response; interferon; viral infection; mathematical modeling; multiplex network
MeSH headings : Humans; Immunity, Innate; Interferon Type I / immunology; Models, Immunological; Signal Transduction / immunology; Virus Diseases / immunology; Viruses / immunology
Source: Web Of Science
Added: August 12, 2019

2019 journal article

Within-host infectious disease models accommodating cellular coinfection, with an application to influenza

VIRUS EVOLUTION, 5(2).

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: influenza virus; within-host dynamics; macroparasite model; cellular coinfection; viral complementation
Source: Web Of Science
Added: January 13, 2020

2018 journal article

Determinants of the efficacy of HIV latency-reversing agents and implications for drug and treatment design

JCI INSIGHT, 3(20).

By: R. Ke*, J. Conway, D. Margolis & A. Perelson

MeSH headings : Anti-HIV Agents / pharmacology; Anti-HIV Agents / therapeutic use; CD4-Positive T-Lymphocytes / drug effects; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / virology; Drug Design; Drug Therapy, Combination / methods; HIV Antigens / metabolism; HIV Infections / drug therapy; HIV Infections / immunology; HIV Infections / virology; HIV-1 / drug effects; HIV-1 / physiology; Humans; Models, Biological; Pulse Therapy, Drug; Treatment Outcome; Virus Latency / drug effects
Source: Web Of Science
Added: November 12, 2018

2018 conference paper

Network analysis of virus-innate immune interaction within a host

2018 52nd Annual Conference on Information Sciences and Systems (CISS).

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Variation in cell-associated unspliced HIV RNA on antiretroviral therapy is associated with the circadian regulator brain-and-muscle-ARNT-like-1

AIDS, 32(15), 2119โ€“2128.

By: C. Changโ€‰*, V. Naranbhaiโ€‰*, J. Stern*, M. Rocheโ€‰*, A. Dantanarayana*, R. Ke*, S. Tennakoon*, A. Solomon* ...

co-author countries: Australia ๐Ÿ‡ฆ๐Ÿ‡บ United Kingdom of Great Britain and Northern Ireland ๐Ÿ‡ฌ๐Ÿ‡ง United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: brain-and-muscle-ARNT-like-1; circadian rhythm; HIV; HIV latency; HIV transcription; stress; unspliced RNA
MeSH headings : ARNTL Transcription Factors / biosynthesis; ARNTL Transcription Factors / genetics; Anti-Retroviral Agents / therapeutic use; Blood Cells / virology; Cells, Cultured; Female; Gene Expression Profiling; HIV / growth & development; HIV Infections / drug therapy; HIV Infections / virology; Host-Pathogen Interactions; Humans; Male; Middle Aged; RNA, Viral / analysis; Real-Time Polymerase Chain Reaction; Transcription, Genetic
Source: Web Of Science
Added: January 7, 2019

2017 journal article

NS5A inhibitors unmask differences in functional replicase complex half-life between different hepatitis C virus strains

PLOS PATHOGENS, 13(6).

co-author countries: Italy ๐Ÿ‡ฎ๐Ÿ‡น United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : Half-Life; Hepacivirus / chemistry; Hepacivirus / classification; Hepacivirus / drug effects; Hepacivirus / physiology; Hepatitis C / virology; Humans; Kinetics; Viral Nonstructural Proteins / antagonists & inhibitors; Viral Nonstructural Proteins / chemistry; Viral Nonstructural Proteins / genetics; Viral Nonstructural Proteins / metabolism; Virus Assembly / drug effects; Virus Replication / drug effects
Source: Web Of Science
Added: August 6, 2018

2017 journal article

On the Death Rate of Abortively Infected Cells: Estimation from Simian-Human Immunodeficiency Virus Infection

JOURNAL OF VIROLOGY, 91(18).

co-author countries: United States of America ๐Ÿ‡บ๐Ÿ‡ธ
author keywords: abortive infection; SHIV; mathematical modeling; viral kinetics
MeSH headings : Animals; Cell Death; DNA, Viral / analysis; HIV / growth & development; Macaca mulatta; Models, Theoretical; RNA, Viral / blood; Simian Acquired Immunodeficiency Syndrome / immunology; Simian Acquired Immunodeficiency Syndrome / virology; Simian Immunodeficiency Virus / growth & development; T-Lymphocytes / virology; Viral Load
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Transcriptional Reprogramming during Effector-to-Memory Transition Renders CD4(+) T Cells Permissive for Latent HIV-1 Infection

IMMUNITY, 47(4), 766-+.

By: L. Shanโ€‰*, K. Dengโ€‰*, H. Gaoโ€‰*, S. Xing*, A. Capoferriโ€‰*, C. Durandโ€‰*, S. Rabi*, G. Laird* ...

co-author countries: China ๐Ÿ‡จ๐Ÿ‡ณ Taiwan, Province of China ๐Ÿ‡น๐Ÿ‡ผ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / metabolism; CD4-Positive T-Lymphocytes / virology; Cells, Cultured; Cellular Reprogramming / genetics; Cellular Reprogramming / immunology; Cytokines / genetics; Cytokines / immunology; Female; Flow Cytometry; Gene Expression Profiling / methods; HIV-1 / immunology; HIV-1 / physiology; Host-Pathogen Interactions / immunology; Humans; Immunologic Memory / genetics; Immunologic Memory / immunology; Lymphocyte Activation / genetics; Lymphocyte Activation / immunology; Male; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / metabolism; Transcription, Genetic; Virus Latency / immunology; Virus Replication / immunology
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Modeling the Effects of Vorinostat In Vivo Reveals both Transient and Delayed HIV Transcriptional Activation and Minimal Killing of Latently Infected Cells

PLOS PATHOGENS, 11(10).

By: R. Ke n, S. Lewinโ€‰*, J. Elliott* & A. Perelsonโ€‰*

co-author countries: Australia ๐Ÿ‡ฆ๐Ÿ‡บ United States of America ๐Ÿ‡บ๐Ÿ‡ธ
MeSH headings : HIV / drug effects; HIV / genetics; Histone Deacetylase Inhibitors / pharmacology; Humans; Hydroxamic Acids / pharmacology; Transcriptional Activation / drug effects; Virus Latency; Vorinostat
Source: Web Of Science
Added: August 6, 2018

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