Rita M Hanel

Works (20)

Updated: July 15th, 2023 21:15

2022 article

Bilateral lysis of aortic saddle thrombus with early tissue plasminogen activator (BLASTT): a prospective, randomized, placebo-controlled study in feline acute aortic thromboembolism

Guillaumin, J., DeFrancesco, T. C., Scansen, B. A., Quinn, R., Whelan, M., Hanel, R., … Bonagura, J. D. (2022, November 9). JOURNAL OF FELINE MEDICINE AND SURGERY, Vol. 11.

By: J. Guillaumin *, T. DeFrancesco n , B. Scansen*, R. Quinn*, M. Whelan*, R. Hanel*, I. Goy-Thollot *, I. Bublot, J. Robertson n , J. Bonagura n 

author keywords: Thrombolysis; thrombosis; alteplase; rTPA; embolism; ischemic neuropathy
MeSH headings : Cats; Animals; Tissue Plasminogen Activator / therapeutic use; Anticoagulants; Prospective Studies; Venous Thromboembolism / veterinary; Research Design; Cat Diseases / drug therapy
TL;DR: Survition and complication rates of acute FATE were not different with or without thrombolysis, and high in-hospital mortality decreased the statistical power to detect a statistically significant difference between treatments with regard to the primary outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 28, 2022

2021 journal article

Evaluation of point-of-care coagulation tests as alternatives to anti-Xa activity for monitoring the anticoagulant effects of rivaroxaban in healthy dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 18–24.

By: A. Lynch n , L. Ruterbories n, E. Griffith n, R. Hanel*, A. Stablein* & M. Brooks *

author keywords: anticoagulant; antithrombotic; canine direct oral anticoagulants; thromboembolism
MeSH headings : Administration, Oral; Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Blood Coagulation Tests / veterinary; Dogs; Factor Xa Inhibitors / administration & dosage; Factor Xa Inhibitors / pharmacology; Male; Partial Thromboplastin Time / veterinary; Point-of-Care Testing; Prospective Studies; Prothrombin Time / veterinary; Reference Values; Rivaroxaban / administration & dosage; Rivaroxaban / pharmacology; Thrombelastography / veterinary
TL;DR: Of all the coagulation tests investigated, the PT correlated best with RIVA, and there is potential for PT being a convenient second-line monitoring option in dogs receiving rivaroxaban, but further work is necessary to validate other PT assays. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: November 16, 2020

2021 journal article

The influence of feeding and gastroprotectant medications on the Factor Xa inhibitory activity of orally administered rivaroxaban in normal dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 31(1), 59–65.

By: A. Lynch n , L. Ruterbories n, E. Griffith n, R. Hanel*, A. Stablein* & M. Brooks *

author keywords: anticoagulant; antithrombotic; canine direct oral anticoagulants; thromboembolism
MeSH headings : Administration, Oral; Animals; Anti-Ulcer Agents / administration & dosage; Anti-Ulcer Agents / pharmacology; Anticoagulants / administration & dosage; Anticoagulants / pharmacokinetics; Blood Coagulation Tests / veterinary; Dogs; Factor Xa Inhibitors / administration & dosage; Factor Xa Inhibitors / pharmacokinetics; Male; Meals; Prospective Studies; Reference Values; Rivaroxaban / administration & dosage; Rivaroxaban / pharmacokinetics
TL;DR: Based on results, dogs treated with rivaroxaban do not require special modification of feeding practices or gastroprotectant drug administration and clinically relevant differences among treatment groups were not identified in combined analyses of time points. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: November 16, 2020

2020 journal article

The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 30(4), 418–425.

By: A. Lynch n , L. Ruterbories n, J. Jack n, A. Motsinger-Reif n & R. Hanel*

MeSH headings : Animals; Blood Coagulation Tests / veterinary; Blood Proteins / physiology; Cell Size; Dogs / blood; Female; Fibrinogen / metabolism; Hematocrit / veterinary; Male; Thrombelastography / veterinary
TL;DR: In an ex vivo model, plasma proteins but not PCV impacted TEG variables, suggesting that TEG changes noted with anemia are imparted by changes in available fibrinogen in a fixed microenvironment rather than artifact of anemia. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: July 13, 2020

2019 journal article

Baseline plasma thromboelastography in Kemp’s ridley (Lepidochelys kempii), green (Chelonia mydas) and loggerhead (Caretta caretta) sea turtles and its use to diagnose coagulopathies in cold-stunned Kemp’s ridley and green sea turtles

Journal of Zoo and Wildlife Medicine, 50(1), 62.

By: A. Barratclough*, K. Tuxbury *, R. Hanel n, N. Stacy *, L. Ruterbories n, E. Christiansen*, C. Harms n 

author keywords: Coagulation; coagulopathy; cold stunned; sea turtle; thromboelastography
MeSH headings : Animals; Cold Temperature / adverse effects; Hemostasis; Plasma / chemistry; Reference Values; Species Specificity; Thrombelastography / veterinary; Turtles / blood
TL;DR: Findings indicate that cold stunning may cause disorders in hemostasis that can contribute to the severity of the condition and early diagnosis of coagulopathies in the clinical assessment of a cold-stunned sea turtle may influence the treatment approach and clinical outcome of the case. (via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action (Web of Science)
14. Life Below Water (Web of Science; OpenAlex)
15. Life on Land (Web of Science)
Sources: Web Of Science, ORCID, Crossref
Added: April 22, 2019

2018 journal article

A pilot study documenting increased thrombin generation following abrupt withdrawal of heparin therapy in healthy dogs

Journal of Veterinary Emergency and Critical Care, 28(6), 518–526.

By: E. Mays n, D. Dorman n, C. McKendry n & R. Hanel n

author keywords: hypercoagulable; rebound; thromboelastography
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Dogs; Heparin / administration & dosage; Heparin / pharmacology; Infusions, Intravenous / veterinary; Male; Pilot Projects; Prospective Studies; Thrombelastography / veterinary; Thrombin / biosynthesis; Thrombin / drug effects
TL;DR: Results suggest that a transient increase in thrombin generation developed 12 hours after withdrawal of UFH therapy, which is similar to that seen in healthy dogs following abrupt cessation of unfractionated heparin (UFH) therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: November 26, 2018

2017 journal article

Evaluation of the Lactate Plus monitor for plasma lactate concentration measurement in dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 66–70.

By: C. Nye n, S. Musulin n , R. Hanel n & C. Mariani n 

author keywords: canine; metabolic acidosis; perfusion; point of care; shock; validation
MeSH headings : Animals; Blood Gas Analysis / instrumentation; Blood Gas Analysis / veterinary; Dogs; Emergency Medical Services; Female; Lactic Acid / blood; Male; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / veterinary; Point-of-Care Systems; Prospective Studies; Reproducibility of Results
TL;DR: The Lactate Plus provides a fast and affordable method to measure plasma lactate concentration in dogs and shows excellent agreement with the reference analyzer and precision of the instrument was acceptable. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 27(1), 71–81.

By: C. McLaughlin n, S. Marks n, D. Dorman n, A. Motsinger-Reif n & R. Hanel n

author keywords: anticoagulation monitoring; anti-Xa; canine; RapidTEG; thrombosis
MeSH headings : Animals; Anticoagulants / administration & dosage; Anticoagulants / pharmacology; Blood Coagulation / drug effects; Dogs; Female; Heparin / administration & dosage; Heparin / pharmacology; Injections, Subcutaneous / veterinary; Male; Partial Thromboplastin Time / veterinary; Prospective Studies; Reference Values; Thrombelastography / veterinary
TL;DR: This study demonstrates that TEG variables derived using robust activation correlate with AXa activity as well as aPTT and have the potential to be used for monitoring UFH therapy in healthy dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Best practice recommendations for prehospital veterinary care of dogs and cats

Journal of Veterinary Emergency and Critical Care, 26(2), 166–233.

By: R. Hanel n, L. Palmer, J. Baker, J. Brenner, D. Crowe, D. Dorman n, J. Gicking, B. Gilger n  ...

author keywords: cat; dog; first response; trauma; VetCOT
MeSH headings : Animals; Cats; Consensus; Databases, Factual; Dogs; Emergency Service, Hospital / standards; Practice Guidelines as Topic; Practice Management, Veterinary / standards; United States; Veterinary Medicine / standards; Wounds and Injuries / therapy; Wounds and Injuries / veterinary
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2015 journal article

Coagulation abnormalities in 5 cats with naturally occurring cytauxzoonosis

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 25(4), 538–545.

By: B. Conner  n, R. Hanel n, M. Brooks *, L. Cohn* & A. Birkenheuer n 

author keywords: disseminated intravascular coagulation; feline; sepsis; thromboelastography
MeSH headings : Animals; Blood Cell Count / veterinary; Blood Coagulation Tests / veterinary; Cat Diseases / blood; Cats; Cross-Sectional Studies; Disseminated Intravascular Coagulation / blood; Disseminated Intravascular Coagulation / veterinary; Female; Fibrinogen; Hemostasis; Male; Piroplasmida; Prothrombin Time / veterinary; Protozoan Infections / blood; Sepsis / blood; Sepsis / veterinary; Thrombelastography / veterinary
TL;DR: This is the first report that comprehensively describes the hemostastic status of cats with naturally occurring infection with Cytauxzoon felis and all 5 cats had laboratory evidence of overt DIC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

Presumptive intraperitoneal envenomation resulting in hemoperitoneum and acute abdominal pain in a dog

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 25(6), 770–777.

By: S. Istvan n, J. Walker*, B. Hansen n, R. Hanel n & S. Marks n

author keywords: acute abdomen; canine; envenomation; hemoabdomen; local analgesia
MeSH headings : Abdominal Pain / etiology; Abdominal Pain / veterinary; Animals; Antivenins / therapeutic use; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Hemoperitoneum / etiology; Hemoperitoneum / veterinary; Male; Snake Bites / complications; Snake Bites / therapy; Snake Bites / veterinary; Viperidae
TL;DR: This is the first report of IP envenomation accompanied by hemorrhage treated with continuous IP analgesia in the veterinary literature. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation

AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(5), 425–432.

By: M. Bucknoff n, R. Hanel n, S. Marks n, A. Motsinger-Reif n & S. Suter n

MeSH headings : Animals; Bone Marrow Transplantation / veterinary; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Hemorrhage / diagnosis; Hemorrhage / physiopathology; Hemorrhage / veterinary; Hemostasis / physiology; Kaolin; Lymphoma / physiopathology; Lymphoma / veterinary; Male; Platelet Count / veterinary; Prospective Studies; Thrombelastography / methods; Thrombelastography / veterinary; Thrombocytopenia / physiopathology; Thrombocytopenia / veterinary; Whole-Body Irradiation / veterinary
TL;DR: Compared with buccal mucosal bleeding time and platelet count, thromboelastography was more reliable at identifying thrombocytopenic dogs with a low risk of bleeding and could be considered to help guide the use of transfusion products in dogs undergoing TBI and BMT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Prospective multicenter evaluation of coagulation abnormalities in dogs following severe acute trauma

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 24(1), 93–104.

By: M. Holowaychuk *, R. Hanel n, R. Wood*, L. Rogers*, K. O'Keefe* & G. Monteith*

author keywords: hemostasis; hemorrhage; hypotension; lactate; perfusion; thromboelastography
MeSH headings : Animals; Blood Coagulation Disorders / etiology; Blood Coagulation Disorders / pathology; Blood Coagulation Disorders / veterinary; Dog Diseases / etiology; Dogs; Female; Humans; Male; Shock / complications; Shock / veterinary; Wounds and Injuries / pathology; Wounds and Injuries / veterinary
TL;DR: In dogs with severe traumatic injuries and hypoperfusion, measurement of thromboelastography and aPTT should be considered to support clinical assessments in predicting the need for blood product administration and nonsurvival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Systematic evaluation of evidence on veterinary viscoelastic testing Part 4: Definitions and data reporting

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 24(1), 47–56.

By: R. Hanel n, D. Chan *, B. Conner *, V. Gauthier*, M. Holowaychuk *, S. Istvan, J. Walker*, D. Wood*, R. Goggs *, B. Wiinberg*

author keywords: cat; dog; thromboelastometry; thromboelastography
MeSH headings : Animals; Blood Specimen Collection / methods; Blood Specimen Collection / standards; Blood Specimen Collection / veterinary; Cats / blood; Dogs / blood; Horses / blood; Reference Standards; Thrombelastography / instrumentation; Thrombelastography / methods; Thrombelastography / veterinary; Veterinary Medicine / standards
TL;DR: It is suggested that standard TEG/ROTEM assays may be unable to detect hypofibrinolysis in companion animals, and it is recommended that every center establish reference intervals, which are specific to either TEG or ROTEM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Bacterial Contamination of Stethoscope Chest Pieces and the Effect of Daily Cleaning

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(2), 354–358.

By: H. Fujita*, B. Hansen n & R. Hanel n

author keywords: Hospital-acquired infection; Nosocomial
MeSH headings : 2-Propanol / pharmacology; Animals; Bacteria / isolation & purification; Bacterial Infections / microbiology; Bacterial Infections / prevention & control; Bacterial Infections / veterinary; Cat Diseases / microbiology; Cat Diseases / prevention & control; Cat Diseases / transmission; Cats; Colony Count, Microbial; Dog Diseases / microbiology; Dog Diseases / prevention & control; Dog Diseases / transmission; Dogs; Prospective Studies; Stethoscopes / microbiology
TL;DR: Daily cleaning was highly effective at removing bacteria, but provided no reduction in precleaning contamination, and cleaning stethoscopes after use on dogs or cats infected with pathogenic bacteria and before use on immunocompromised animals should be considered. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Hypercoagulability in Dogs with Protein-Losing Nephropathy as Assessed by Thromboelastography

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(3), 462–468.

By: E. Lennon n, R. Hanel n, J. Walker n & S. Vaden n

author keywords: Antithrombin; Hypoalbuminemia; Proteinuria; Thromboembolism
MeSH headings : Animals; Blood Coagulation Disorders / blood; Blood Coagulation Disorders / epidemiology; Blood Coagulation Disorders / veterinary; Dog Diseases / blood; Dog Diseases / pathology; Dogs; Female; Kidney Diseases / blood; Kidney Diseases / complications; Kidney Diseases / pathology; Kidney Diseases / veterinary; Male; Thrombelastography / veterinary
TL;DR: The results indicate that dogs with PLN have TEG values that demonstrate hypercoagulability compared with a control population but that antithrombin, SALB, or UPC cannot be used in isolation to predict this result. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 article

Comparison of venous sampling methods for thromboelastography in clinically normal dogs

Walker, J. M., Hanel, R. M., Hansen, B. D., & Motsinger-Reif, A. A. (2012, December). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 1864–1870.

By: J. Walker n, R. Hanel*, B. Hansen* & A. Motsinger-Reif*

MeSH headings : Animals; Blood Platelets / physiology; Dogs / blood; Male; Phlebotomy / methods; Phlebotomy / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
TL;DR: Different sampling methods resulted in small but significant differences in thromboelastographic values, but all of these sampling methods were acceptable for 1-time clinical use. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 article

Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid-activated modified thromboelastography in healthy dogs

Conner, B. J., Hanel, R. M., Hansen, B. D., Motsinger-Reif, A. A., Asakawa, M., & Swanson, C. R. (2012, May). AMERICAN JOURNAL OF VETERINARY RESEARCH, Vol. 73, pp. 595–601.

By: B. Conner  n, R. Hanel n, B. Hansen n, A. Motsinger-Reif n, M. Asakawa n & C. Swanson n

MeSH headings : Acepromazine / administration & dosage; Acepromazine / adverse effects; Adenosine Diphosphate / chemistry; Animals; Arachidonic Acid / chemistry; Blood Platelets / drug effects; Blood Platelets / physiology; Cross-Over Studies; Dogs / physiology; Female; Hemostasis / drug effects; Hypnotics and Sedatives / administration & dosage; Hypnotics and Sedatives / adverse effects; Injections, Intravenous / veterinary; Thrombelastography / methods; Thrombelastography / veterinary
TL;DR: Platelet function in dogs, as assessed by use of a modified thromboelastography assay, was not inhibited by acepromazine at doses of 0.05 or 0.1 mg/kg, IV, in contrast to previous reports in which it was suggested that ace Promazine may alter platelet function via inhibition of ADP and AA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Effect of intravenous administration of dextrose on coagulation in healthy dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 72(4), 562–569.

By: J. Gonzales n, R. Hanel n, B. Hansen  n & S. Marks n

MeSH headings : Animals; Blood Coagulation; Dogs / physiology; Glucose / adverse effects; Glucose / chemistry; Hyperglycemia; Infusions, Intravenous; Male; Partial Thromboplastin Time; Prothrombin Time
TL;DR: I administration of dextrose to healthy dogs at rates comparable to or higher than those for conventional parenteral nutrition resulted in mild but clinically unimportant interference with coagulation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Thrombi in the trachea of a dog secondary to placement of a tracheotomy tube

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 233(5), 758–760.

By: K. Fitzwater n, S. Marks* & R. Hanel*

MeSH headings : Airway Obstruction / etiology; Airway Obstruction / surgery; Airway Obstruction / veterinary; Animals; Bronchial Diseases / etiology; Bronchial Diseases / surgery; Bronchial Diseases / veterinary; Dog Diseases / surgery; Dogs; Female; Thrombectomy / methods; Thrombectomy / veterinary; Thrombosis / etiology; Thrombosis / surgery; Thrombosis / veterinary; Tracheal Diseases / surgery; Tracheal Diseases / veterinary; Tracheotomy / adverse effects; Tracheotomy / veterinary; Treatment Outcome
TL;DR: Airway obstruction resulting from an intraluminal thrombus in the trachea should be considered as a secondary complication after tracheotomy tube placement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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