Radhika N. Shah

author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin

MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism

TL;DR: It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo. (via Semantic Scholar)

author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID

MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish

TL;DR: It is hypothesized that the rag1(-/-) zebrafish may possess an "enhanced" innate immune response to compensate for the lack of an adaptive immune system. (via Semantic Scholar)

author keywords: natural cytotoxicity; DAP10; ERK; AKT; DAP12; NITR

MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / immunology; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Sequence; Animals; Cell Line; Humans; Molecular Sequence Data; Phosphorylation; Receptors, KIR / genetics; Receptors, KIR / immunology; Receptors, KIR / metabolism; Recombinant Proteins / immunology; Recombinant Proteins / metabolism; Sequence Alignment; Signal Transduction / immunology; Zebrafish; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology; Zebrafish Proteins / metabolism

TL;DR: Cross-linking the Nitr9L–Dap12 complex results in activation of the phosphytidylinositol 3-kinase→AKT→extracellular signal-regulated kinase pathway suggesting that the DAP12-based activating pathway is conserved between bony fish and mammals. (via Semantic Scholar)