Works (3)

Updated: July 9th, 2023 21:17

2017 journal article

Disruption of Trim9 function abrogates macrophage motility in vivo

Journal of Leukocyte Biology, 102(6), 1371–1380.

By: D. Tokarz n, A. Heffelfinger n, D. Jima n, J. Gerlach n, R. Shah n, I. Rodriguez-Nunez n, A. Kortum n, A. Fletcher n ...

author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR: It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity

Molecular Immunology, 46(7), 1505–1516.

By: D. Jima n, R. Shah n, T. Orcutt n, D. Joshi*, J. Law n, G. Litman*, N. Trede*, J. Yoder n

author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID
MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish
TL;DR: It is hypothesized that the rag1(-/-) zebrafish may possess an "enhanced" innate immune response to compensate for the lack of an adaptive immune system. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

The zebrafish activating immune receptor Nitr9 signals via Dap12

Immunogenetics, 59(10), 813–821.

By: S. Wei*, J. Zhou*, X. Chen*, R. Shah n, J. Liu*, T. Orcutt n, D. Traver*, J. Djeu* ...

author keywords: natural cytotoxicity; DAP10; ERK; AKT; DAP12; NITR
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / immunology; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Sequence; Animals; Cell Line; Humans; Molecular Sequence Data; Phosphorylation; Receptors, KIR / genetics; Receptors, KIR / immunology; Receptors, KIR / metabolism; Recombinant Proteins / immunology; Recombinant Proteins / metabolism; Sequence Alignment; Signal Transduction / immunology; Zebrafish; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology; Zebrafish Proteins / metabolism
TL;DR: Cross-linking the Nitr9L–Dap12 complex results in activation of the phosphytidylinositol 3-kinase→AKT→extracellular signal-regulated kinase pathway suggesting that the DAP12-based activating pathway is conserved between bony fish and mammals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

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