Works (3)
Updated: July 9th, 2023 21:17
2017 journal article
Disruption of Trim9 function abrogates macrophage motility in vivo
Journal of Leukocyte Biology, 102(6), 1371–1380.
author keywords: chemotaxis; zebrafish; leukocyte; ubiquitin
MeSH headings : Animals; Cell Movement / genetics; Cell Shape; Chemotaxis; Humans; Macrophages / cytology; Macrophages / metabolism; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Tripartite Motif Proteins / genetics; Tripartite Motif Proteins / metabolism; U937 Cells; Ubiquitin-Protein Ligases / genetics; Ubiquitin-Protein Ligases / metabolism; Zebrafish / genetics; Zebrafish / immunology; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
TL;DR:
It is demonstrated that Trim9 mediates cellular movement and migration in Mϕs as well as neurons, and is implicated in axonal migration, and found that M ϕ chemotaxis and cellular architecture are subsequently impaired in vivo.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2009 journal article
Enhanced transcription of complement and coagulation genes in the absence of adaptive immunity
Molecular Immunology, 46(7), 1505–1516.
author keywords: Zebrafish; Mouse; rag1; Innate immunity; SCID
MeSH headings : Adaptation, Physiological / genetics; Adaptation, Physiological / immunology; Animals; Animals, Genetically Modified; Blood Coagulation Factors / genetics; Blood Coagulation Factors / metabolism; Complement C4 / genetics; Complement C4 / metabolism; Complement System Proteins / genetics; Complement System Proteins / metabolism; Female; Gene Expression Profiling; Genes, RAG-1 / physiology; Immunity / genetics; Immunity / physiology; Intestinal Mucosa / metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Transcription, Genetic; Up-Regulation; Zebrafish
TL;DR:
It is hypothesized that the rag1(-/-) zebrafish may possess an "enhanced" innate immune response to compensate for the lack of an adaptive immune system.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2007 journal article
The zebrafish activating immune receptor Nitr9 signals via Dap12
Immunogenetics, 59(10), 813–821.
author keywords: natural cytotoxicity; DAP10; ERK; AKT; DAP12; NITR
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Adaptor Proteins, Signal Transducing / immunology; Adaptor Proteins, Signal Transducing / metabolism; Amino Acid Sequence; Animals; Cell Line; Humans; Molecular Sequence Data; Phosphorylation; Receptors, KIR / genetics; Receptors, KIR / immunology; Receptors, KIR / metabolism; Recombinant Proteins / immunology; Recombinant Proteins / metabolism; Sequence Alignment; Signal Transduction / immunology; Zebrafish; Zebrafish Proteins / genetics; Zebrafish Proteins / immunology; Zebrafish Proteins / metabolism
TL;DR:
Cross-linking the Nitr9L–Dap12 complex results in activation of the phosphytidylinositol 3-kinase→AKT→extracellular signal-regulated kinase pathway suggesting that the DAP12-based activating pathway is conserved between bony fish and mammals.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
14. Life Below Water
(OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
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