Rachael Thomas

Works (50)

Updated: April 20th, 2024 05:00

2024 journal article

The development of non-destructive sampling methods of parchment skins for genetic species identification

PLOS ONE, 19(3).

By: M. Scheible*, T. Stinson* , M. Breen*, B. Callahan* , R. Thomas* & K. Meiklejohn* 

Ed(s): A. Shakoori

TL;DR: A workflow for enriching the mitochondrial genome (mtGenome), generating next-generation sequencing reads to permit species identification, and providing interpretation guidance is defined, defining a workflow for enriching the mitochondrial genome, generating next-generation sequencing reads to permit species identification, and providing interpretation guidance. (via Semantic Scholar)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 22, 2024

2023 journal article

The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone

SCIENCE ADVANCES, 9(9).

By: G. Spatola *, R. Buckley *, M. Dillon n, E. V. Dutrow *, J. Betz *, M. Pilot *, H. Parker *, W. Bogdanowicz * ...

MeSH headings : Dogs; Animals; Chernobyl Nuclear Accident; Environment; Disasters; Environmental Pollution; Demography
TL;DR: This study presents the first characterization of a domestic species in Chernobyl, establishing their importance for genetic studies into the effects of exposure to long-term, low-dose ionizing radiation. (via Semantic Scholar)
Source: Web Of Science
Added: April 4, 2023

2023 journal article

Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption

PLOS GENETICS, 19(4).

By: R. Thomas n, C. Wiley n, E. Droste n, J. Robertson n , B. Inman * & M. Breen n

Ed(s): T. Leeb

MeSH headings : Dogs; Animals; Humans; Urinary Bladder Neoplasms / genetics; Urinary Bladder Neoplasms / veterinary; Carcinoma, Transitional Cell / genetics; Carcinoma, Transitional Cell / veterinary; Proto-Oncogene Proteins B-raf / genetics; Exome Sequencing; Mutation; MAP Kinase Kinase 1 / genetics
TL;DR: It is suggested that short in-frame deletions within BRAF exon 12 and MAP2K1 exons 2 and 3 in UDV595E cases are alternative MAPK-pathway activating events that may have significant therapeutic implications for selecting first-line treatment for canine UC. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: May 15, 2023

2022 journal article

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

By: A. Lewis *, R. Thomas*, M. Breen*, K. Peden*, B. Teferedegne*, G. Foseh*, A. Motsinger-Reif n, D. Rotroff n, G. Lewis

MeSH headings : Animals; Humans; Chlorocebus aethiops; MicroRNAs / genetics; MicroRNAs / metabolism; Neoplasms / genetics; Carcinogenesis / genetics; DNA Copy Number Variations / genetics; Chromosome Aberrations; Neoplasms, Second Primary / genetics; DNA; Gene Expression Regulation, Neoplastic; Gene Expression Profiling
TL;DR: The evolution of chromosomal DNA copy-number aberrations and miRNA expression in this cell line from passage 1 to the acquisition of a tumorigenic phenotype at passage 40 is examined and it is proposed that the evolution of AGMK1-9T7 cells represents a detailed model of neoplasia in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 27, 2023

2021 journal article

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

MOLECULAR CANCER RESEARCH, 19(5), 847–861.

By: J. Kim *, K. Megquier *, R. Thomas n, A. Sarver*, J. Song *, Y. Kim*, N. Cheng*, A. Schulte* ...

MeSH headings : Animals; Dog Diseases / genetics; Dogs; Gene Expression Profiling / methods; Gene Fusion; Genomics / methods; Hemangiosarcoma / genetics; Humans; Transcription, Genetic; Vascular Neoplasms / genetics
TL;DR: While drive events of malignant vasoformative tumors of humans and dogs include diverse mutations and stochastic rearrangements that create novel fusion genes, convergent transcriptional programs govern the highly conserved morphologic organization and biological behavior of these tumors in both species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 10, 2021

2020 article

A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans

LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.

By: A. LeBlanc *, C. Mazcko *, M. Breen n, R. Thomas n & D. Thamm *

TL;DR: This work exemplifies the type of approach meant to further establish the comparative relevance of canine to human cancer and provide opportunities to explore hypotheses related to detection and treatment in both species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: March 8, 2021

2020 journal article

Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers

VETERINARY SCIENCES, 7(3).

By: R. Thomas n, J. Pontius*, L. Borst n  & M. Breen n

author keywords: feline; cat; cancer; genomics; chromosome; comparative genomic hybridization (CGH)
TL;DR: A microarray platform that allows rapid and sensitive detection of DNA copy number aberrations in feline tumors using comparative genomic hybridization analysis is developed and shown to have diverse potential to incorporate domestic cat cancers into comparative and translational research efforts in molecular oncology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: November 9, 2020

2020 article

Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.

By: J. Kim *, K. Megquier *, A. Sarver*, R. Thomas n, A. Schulte*, C. Wang *, I. Elvers*, E. Karlsson * ...

TL;DR: The data suggests that genomic instability induced by TP53 mutations might create a predisposition for fusion events that may contribute to tumor progression by promoting selection and/or enhancing fitness through activation of convergent angiogenic pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: March 8, 2021

2019 journal article

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma

MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.

By: K. Megquier *, J. Turner-Maier *, R. Swofford *, J. Kim *, A. Sarver*, C. Wang *, S. Sakthikumar *, J. Johnson * ...

MeSH headings : Animals; Blood Vessels / pathology; Breast / metabolism; Breast / pathology; Class I Phosphatidylinositol 3-Kinases / genetics; Class Ia Phosphatidylinositol 3-Kinase / genetics; Cyclin-Dependent Kinase Inhibitor p15 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Dogs; Female; Genome / genetics; Genomics; Hemangiosarcoma / genetics; Hemangiosarcoma / pathology; Humans; Mutation / genetics; Tumor Suppressor Protein p53 / genetics; Viscera / metabolism; Viscera / pathology; Exome Sequencing
TL;DR: Canine hemangiosarcoma closely models the genomic landscape of human angiosarComa of the breast and viscera, and is a powerful tool for investigating the pathogenesis of this devastating disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: December 30, 2019

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

By: K. Kennedy n, R. Thomas n, J. Durrant n, T. Jiang n, A. Motsinger-Reif n & M. Breen n

author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
MeSH headings : Animals; Chromosome Disorders; DNA Copy Number Variations / genetics; Dog Diseases / diagnosis; Dog Diseases / genetics; Dogs; Gene Expression Profiling; Genome / genetics; Histiocytic Disorders, Malignant / diagnosis; Histiocytic Disorders, Malignant / genetics; Histiocytic Disorders, Malignant / veterinary; Humans; Immunohistochemistry / methods; Matrix Metalloproteinase 9 / metabolism; Spindle Apparatus / pathology
TL;DR: Droplet digital PCR evaluation of these regions in numerous cancer specimens effectively discriminated HM from other common round cell tumors, including lymphoma and hemangiosarcoma, resulting in a novel, rapid diagnostic aid for veterinary medicine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Source: Web Of Science
Added: September 30, 2019

2018 article

Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.

By: J. Kim *, K. Megquier *, A. Sarver*, R. Thomas n, C. Wang *, I. Elvers*, E. Karlsson *, M. Breen n, K. Lindblad-Toh *, J. Modiano *

Source: Web Of Science
Added: June 24, 2019

2017 journal article

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

By: J. Lim*, S. Koh*, R. Thomas*, M. Breen* & N. Olby* 

MeSH headings : Adipose Tissue / cytology; Animals; Cells, Cultured; Comparative Genomic Hybridization; Dogs; Female; Gene Dosage / genetics; Gene Expression Profiling; Gene Expression Regulation; Male; Neural Stem Cells / cytology; Neural Stem Cells / pathology; Neurons / cytology; Neurons / pathology; Proteins / genetics; Spinal Cord Injuries / physiopathology; Spinal Cord Injuries / veterinary; Stromal Cells / cytology; Stromal Cells / physiology
TL;DR: ADSCs can potentially be a safe and clinically relevant autologous source for canine neural progenitor cells and DNA copy number stability was suggested by the methods used. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2017 journal article

Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

CHROMOSOME RESEARCH, 25(2), 129–143.

By: H. Mochizuki n , R. Thomas n, S. Moroff & M. Breen n

author keywords: Cancer; Comparative genomic hybridization; Digital PCR; Dog; Mastocytosis; Pug
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dogs; Genome / genetics; Mastocytosis, Cutaneous / diagnosis; Mastocytosis, Cutaneous / genetics; Mastocytosis, Cutaneous / pathology; Mutation; Predictive Value of Tests; Proto-Oncogene Proteins c-kit / genetics; Sensitivity and Specificity
TL;DR: Characterization of genomic alterations in canine MCTs may identify genomic regions and/or genes responsible for their development and progression, facilitating the discovery of new therapeutic targets and improved clinical management of this heterogeneous cancer. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 852–867.

By: R. Thomas n, Z. Demeter*, K. Kennedy n, L. Borst n , K. Singh *, V. Valli, K. Le Boedec *, M. Breen n

author keywords: BCL2; canine; comparative genomic hybridization; fluorescence in situ hybridization; follicular lymphoma; immunohistochemistry
MeSH headings : Animals; DNA Copy Number Variations / genetics; DNA Fingerprinting / veterinary; Dog Diseases / etiology; Dog Diseases / genetics; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study / veterinary; Lymphoma, Follicular / etiology; Lymphoma, Follicular / genetics; Lymphoma, Follicular / pathology; Lymphoma, Follicular / veterinary; Male; Risk Factors
TL;DR: Parallel exploration of canine and human cases may reveal alternative tumour-initiating mechanisms other than BCL2 disruption, yielding a more complete definition of the molecular pathogenesis of FL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity

CHROMOSOME RESEARCH, 23(4), 663–680.

By: R. Omeir*, R. Thomas n, B. Teferedegne*, C. Williams n, G. Foseh*, J. Macauley*, L. Brinster*, J. Beren* ...

author keywords: Neoplastic transformation; Tumorigenicity; Canine chromosomes; Comparative genomic hybridization (CGH); Fluorescence in situ hybridization (FISH); Madin-Darby canine kidney (MDCK) cell line; CKB1-3T7 cell line
MeSH headings : Animals; Cell Line; Cell Line, Transformed; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic / genetics; Cells, Cultured; Chromosome Aberrations; DNA Copy Number Variations; Dogs; In Situ Hybridization, Fluorescence; Karyotype; Madin Darby Canine Kidney Cells; Male; Neoplasms / genetics; Neoplasms / pathology
TL;DR: Through integrated cytogenomic and phenotypic characterization of serial passages of CKB1-3T7 from initiation to development of a tumorigenic phenotype, this work presents a robust and readily accessible model of spontaneous neoplastic transformation that overcomes many of the limitations of earlier studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo

PROSTATE, 74(13), 1251–1265.

By: J. Simmons*, W. Dirksen*, B. Hildreth *, C. Dorr n, C. Williams n, R. Thomas n, M. Breen n, R. Toribio *, T. Rosol *

author keywords: prostate cancer; osteoblastic metastases; canine; dog
MeSH headings : Animals; Biomarkers, Tumor / genetics; Biomarkers, Tumor / metabolism; Bone Neoplasms / genetics; Bone Neoplasms / metabolism; Bone Neoplasms / secondary; Carcinoma / genetics; Carcinoma / metabolism; Carcinoma / secondary; Cell Line, Tumor; Cell Movement; Cell Proliferation; Dogs; Male; Mice; Mice, Nude; Neoplasm Transplantation; Osteoblasts / metabolism; Osteoblasts / pathology; Prostatic Neoplasms / genetics; Prostatic Neoplasms / metabolism; Prostatic Neoplasms / pathology
TL;DR: This study established and characterized a novel canine prostate cancer cell line that will contribute to the understanding of prostate cancer pathogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

By: R. Thomas n, L. Borst n , D. Rotroff n, A. Motsinger-Reif n, K. Lindblad-Toh *, J. Modiano *, M. Breen n

author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
MeSH headings : Animals; Breeding; Comparative Genomic Hybridization; DNA Copy Number Variations / genetics; Dog Diseases / genetics; Dogs; Gene Amplification; Gene Expression Profiling; Genetic Heterogeneity; Genome; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Penetrance; Vascular Endothelial Growth Factor A / genetics
TL;DR: Analysis of genome-wide microarray-based somatic DNA copy number profiling of 75 primary intra-abdominal hemangiosarcomas from five popular dog breeds supports prior transcriptional studies suggesting that the clinical heterogeneity of this cancer may reflect the existence of multiple, molecularly distinct subtypes of canine hemangiusarcoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

Stem Cells and Development, 22(6), 951–963.

By: S. Koh n, R. Thomas n, S. Tsai n, S. Bischoff n, J. Lim n, M. Breen n, N. Olby n , J. Piedrahita n

MeSH headings : Alkaline Phosphatase / metabolism; Animals; Antigens, Differentiation / genetics; Antigens, Differentiation / metabolism; Cell Differentiation; Cell Shape; Cells, Cultured; Chromosomal Instability; Coculture Techniques; Comparative Genomic Hybridization; Dogs; Fibroblasts / physiology; Gene Expression; In Situ Hybridization, Fluorescence; Induced Pluripotent Stem Cells / enzymology; Induced Pluripotent Stem Cells / pathology; Induced Pluripotent Stem Cells / transplantation; Kruppel-Like Factor 4; Mice; Mice, SCID; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Teratoma / genetics; Teratoma / pathology; Transcription Factors / biosynthesis; Transcription Factors / genetics
TL;DR: The isolated ciPSCs have similar characteristics to ESCs from other species, but the exact cellular mechanisms behind their unique co-dependency on both FGF2 and LIF are still unknown. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

By: D. Rotroff n, R. Thomas n, M. Breen n & A. Motsinger-Reif n

author keywords: cancer; canine model; chemotherapy; clinical trials
MeSH headings : Animals; Disease Models, Animal; Dogs; Humans; Neoplasms / drug therapy; Neoplasms / pathology; Pharmacogenetics / methods
TL;DR: Dogs exhibit a wide variety of spontaneous cancers that share extensive clinicopathologic features with those of human patients, offering a unique opportunity for comparative analysis of cancer etiology and pharmacogenomics. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas

Cancer, 118(23), 5878–5887.

By: A. Italiano *, C. Chen *, R. Thomas n, M. Breen n, F. Bonnet*, N. Sevenet *, M. Longy *, R. Maki *, J. Coindre*, C. Antonescu *

author keywords: angiosarcoma; p53; phosphoinositide-3-kinase; catalytic; alpha polypeptide; phosphatase and tensin homolog; complex karyotype
MeSH headings : Adult; Aged; Aged, 80 and over; Class I Phosphatidylinositol 3-Kinases; Female; Genes, p53; Genomics; Hemangiosarcoma / etiology; Hemangiosarcoma / genetics; Humans; Male; Middle Aged; Mutation; PTEN Phosphohydrolase / genetics; Phosphatidylinositol 3-Kinases / physiology; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins c-akt / physiology; Proto-Oncogene Proteins c-mdm2 / analysis; Signal Transduction / physiology; TOR Serine-Threonine Kinases / physiology
TL;DR: The p53 and phosphoinositide‐3‐kinase, catalytic, alpha polypeptide/v‐akt murine thymoma viral oncogene homolog/mechanistic target of rapamycin (PIK3CA/AKT/mTOR) pathways frequently are altered in sarcoma with complex genomics, such as leiomyosarcoma (LMS) or undifferentiated pleomorphic sarcomA (UPS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: June 6, 2020

2012 journal article

CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies

LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.

By: D. Ito, A. Frantz, C. Williams*, R. Thomas n, R. Burnett*, A. Avery*, M. Breen n, N. Mason *, . Timothy D. O'Brien, J. Modiano *

author keywords: Diffuse large B-cell lymphoma; CD40L; primary cell culture; canine model; cytotoxicity assay
MeSH headings : Animals; CD40 Ligand / genetics; CD40 Ligand / metabolism; CD40 Ligand / pharmacology; Cell Culture Techniques / methods; Cell Proliferation / drug effects; Cell Survival / drug effects; Coculture Techniques; Dogs; Dose-Response Relationship, Drug; Feeder Cells / metabolism; Gene Expression Profiling; Humans; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Oligonucleotide Array Sequence Analysis; Recombinant Proteins / pharmacology; Tumor Cells, Cultured
TL;DR: This work used primary canine diffuse large B-cell lymphoma to establish a culture system that reliably supports the growth of these cells in vitro and illustrates the utility of the feeder cell-free culture system for comparable assessment of cytotoxicity using dog and human B- cell malignancies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 conference paper

Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts

Reproduction in Domestic Animals, 47, 418–419.

By: S. Koh, S. Tsai, S. Bischoff, R. Thomas, J. Lim, M. Breen, N. Olby , J. Piedrahita

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

GENES CHROMOSOMES & CANCER, 51(6), 569–578.

By: A. Italiano *, R. Thomas n, M. Breen n, L. Zhang *, A. Crago *, S. Singer *, R. Khanin*, R. Maki * ...

MeSH headings : Adult; Aged; Aged, 80 and over; Comparative Genomic Hybridization; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / genetics; Female; Gene Amplification; Gene Expression Regulation, Neoplastic; Genes, myc; Hemangiosarcoma / chemistry; Hemangiosarcoma / genetics; Hemangiosarcoma / metabolism; Humans; In Situ Hybridization, Fluorescence; Male; MicroRNAs / biosynthesis; MicroRNAs / genetics; Middle Aged; Proto-Oncogene Proteins c-myc / biosynthesis; Proto-Oncogene Proteins c-myc / genetics; RNA, Long Noncoding; Sequence Analysis, RNA; Thrombospondin 1 / biosynthesis; Thrombospondin 1 / genetics; Transcription Factors / biosynthesis; Transcription Factors / genetics; Vascular Neoplasms / chemistry; Vascular Neoplasms / genetics; Vascular Neoplasms / metabolism
TL;DR: MyC amplification may play a crucial role in the angiogenic phenotype of AS through upregulation of the miR‐17‐92 cluster, which subsequently downregulates THBS1, a potent endogenous inhibitor of angiogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

CHROMOSOME RESEARCH, 19(6), 685–708.

By: S. Becker n, R. Thomas n, V. Trifonov *, R. Wayne *, A. Graphodatsky * & M. Breen n

author keywords: B chromosomes; fragile breakage model; breakpoint reuse theory; fluorescence in situ hybridization; phylogenetic; Canidae
MeSH headings : Animals; Biological Evolution; Canidae / genetics; Chromosome Mapping; Chromosome Painting; Chromosomes, Artificial, Bacterial; Chromosomes, Mammalian / genetics; Cytogenetics; Dogs / genetics; Foxes / genetics; Genome; In Situ Hybridization, Fluorescence; Raccoon Dogs / genetics
TL;DR: This work suggests that the complex karyotype rearrangements associated with speciation of the Canidae reflect unstable chromosome regions described by the fragile breakage model and provides evidence that these breakpoints are also recurrently associated with spontaneous canine cancers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart

GENES CHROMOSOMES & CANCER, 50(11), 859–874.

By: A. Angstadt n, A. Motsinger-Reif n, R. Thomas n, W. Kisseberth *, C. Couto *, D. Duval *, D. Nielsen n , J. Modiano *, M. Breen n

MeSH headings : Animals; Bone Neoplasms / genetics; Bone Neoplasms / veterinary; Comparative Genomic Hybridization; Core Binding Factor Alpha 1 Subunit / genetics; DNA Copy Number Variations; Dog Diseases / genetics; Dogs; Female; Gene Dosage; Genomic Instability; Humans; In Situ Hybridization, Fluorescence; Male; Membrane Proteins / genetics; Osteosarcoma / genetics; Osteosarcoma / veterinary; PTEN Phosphohydrolase / genetics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Tumor Suppressor Proteins / genetics
TL;DR: Large scale screening of genomic imbalance in canine OS further validates the use of the dog as a suitable model for human cancers, supporting the idea that dysregulation discovered in canine cancers will provide an avenue for complementary study in human counterparts. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

FLT3 mutations in canine acute lymphocytic leukemia

BMC CANCER, 11.

By: S. Suter n, G. Small *, E. Seiser n, R. Thomas n, M. Breen n & K. Richards n

MeSH headings : Amino Acid Sequence; Animals; Blotting, Western; Carbazoles / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; DNA Mutational Analysis; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases / metabolism; Furans; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Mutation; Phosphorylation / drug effects; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Reverse Transcriptase Polymerase Chain Reaction; STAT5 Transcription Factor / metabolism; fms-Like Tyrosine Kinase 3 / antagonists & inhibitors; fms-Like Tyrosine Kinase 3 / genetics; fms-Like Tyrosine Kinase 3 / metabolism
TL;DR: Results show that ALL andFLT3 biology is conserved between canine and human patients, supporting the notion that canine ALL, in conjunction with the GL-1 cell line, will be useful in the development of a relevant large animal model to aid in the study of human FLT3 mutant leukemias. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines

Veterinary and Comparative Oncology, 11(1), 30–50.

By: E. Seiser n, R. Thomas n, K. Richards n, M. Kathryn Kelley n, P. Moore *, S. Suter n, M. Breen n

author keywords: canine; cell line; comparative; lymphoid neoplasia; microarray; model
MeSH headings : Animals; Cell Line, Tumor; DNA / genetics; DNA / metabolism; Dog Diseases / metabolism; Dogs; Flow Cytometry; Gene Expression Regulation, Neoplastic / physiology; Karyotype; Lymphoma / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; RNA / genetics; RNA / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Transcriptome
TL;DR: Gene expression profiling and RT-PCR analyses defined the relationship between genomic imbalance and transcriptional dysregulation in each cell line, clarifying their relevance as models of discrete functional pathways with biological and therapeutic significance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas*, E. Seiser*, A. Motsinger-Reif*, L. Borst* , V. Valli, K. Kelley, S. Suter*, D. Argyle ...

author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR: It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 journal article

Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis

CHROMOSOME RESEARCH, 17(7), 927–934.

By: R. Thomas n, C. Rebbeck *, A. Leroi *, A. Burt * & M. Breen n

author keywords: comparative genomic hybridization (CGH); canine; transmissible venereal tumor; chromosome; microarray
MeSH headings : Animals; Comparative Genomic Hybridization; DNA Copy Number Variations; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / transmission; Dogs; Female; Gene Expression Regulation, Neoplastic; Genome; Male; Oligonucleotide Array Sequence Analysis; Venereal Tumors, Veterinary / genetics; Venereal Tumors, Veterinary / immunology
TL;DR: Characterization of a strategically selected panel of CTVT cases is presented using microarray-based comparative genomic hybridization analysis, showing for the first time that the tumor presents with an extensive range of non-random chromosome copy number aberrations that are distributed widely throughout the dog genome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Generation and characterization of novel canine malignant mast cell line CL1

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127(1-2), 114–124.

By: T. Lin *, R. Thomas n, P. Tsai n, M. Breen n & C. London *

author keywords: Mast cell tumor; KIT; Cell line
MeSH headings : Animals; Base Sequence; Cell Degranulation; Cell Line, Tumor; DNA Primers / genetics; DNA, Neoplasm / genetics; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Genome-Wide Association Study; Immunophenotyping; Mast Cells / immunology; Mast Cells / pathology; Mast Cells / physiology; Mastocytosis, Systemic / genetics; Mastocytosis, Systemic / immunology; Mastocytosis, Systemic / pathology; Mastocytosis, Systemic / veterinary; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / metabolism
TL;DR: A novel mast cell line is generated from an 11-year-old spayed female Labrador retriever diagnosed with systemic mastocytosis and neoplastic effusion that possesses phenotypic and functional properties similar to those found in canine BMCMCs, and will likely be a useful tool to study mast cell biology, factors regulating transformation of mast cells, cytogenetic abnormalities in mast cell tumors, and novel preclinical therapies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

IDH1 and IDH2 hotspot mutations are not found in canine glioma

International Journal of Cancer, 127(1), 245–246.

By: Z. Reitman *, N. Olby n , C. Mariani n , R. Thomas n, M. Breen n, D. Bigner*, R. McLendon *, H. Yan *

MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / veterinary; Dogs; Glioma / genetics; Glioma / veterinary; Isocitrate Dehydrogenase / genetics; Isoenzymes / genetics; Mutation
TL;DR: Human diffuse and anaplastic astrocytomas, well-differenti-ated and anaPLastic oligodendrogliomas and secondary glio-blastomas frequently contain somatic mutations of the R132 codon of the cytoplasmic NADPþ-dependent iso-citrate dehydrogenase (IDH1) or the corresponding R172codon in its homolog, IDH2. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 journal article

Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

CHROMOSOME RESEARCH, 17(3), 365–377.

By: R. Thomas n, H. Wang n, P. Tsai n, C. Langford*, S. Fosmire*, C. Jubala*, D. Getzy*, G. Cutter *, J. Modiano *, M. Breen n

author keywords: microarray; comparative genomic hybridization (CGH); canine; osteosarcoma; chromosome
MeSH headings : Animals; Chromosome Aberrations / veterinary; Comparative Genomic Hybridization; Dog Diseases / genetics; Dogs; Genetic Predisposition to Disease / genetics; Karyotyping / veterinary; Osteosarcoma / genetics; Osteosarcoma / veterinary; Species Specificity
TL;DR: Assessment of a cohort of Golden Retrievers and Rottweilers diagnosed with spontaneous appendicular osteosarcoma reveals significant correlations between breed and tumor karyotypes that are independent of gender, age at diagnosis, and histological classification. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

CHROMOSOME RESEARCH, 17(8), 987–1000.

By: R. Thomas n, V. Valli*, P. Ellis*, J. Bell*, E. Karlsson *, J. Cullen n, K. Lindblad-Toh *, C. Langford*, M. Breen n

author keywords: microarray; comparative genomic hybridization (CGH); feline; sarcoma; chromosome
MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Cytogenetic Analysis; DNA Copy Number Variations; Gene Dosage; Gene Expression Profiling; Injections / adverse effects; Oligonucleotide Array Sequence Analysis; Sarcoma / diagnosis; Sarcoma / genetics; Sarcoma / veterinary
TL;DR: Construction of a genomic microarray platform for detection of recurrent CNAs in feline tumors through cytogenetic assignment of 210 large-insert DNA clones selected at intervals of ∼15 Mb from the feline genome sequence assembly is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER

EVOLUTION, 63(9), 2340–2349.

By: C. Rebbeck *, R. Thomas n, M. Breen n, A. Leroi * & A. Burt *

author keywords: Chromosomal evolution; evolutionary genomics; genetic variation; molecular evolution; population genetics; sex
MeSH headings : Animals; Biological Evolution; Comparative Genomic Hybridization / methods; Dog Diseases / genetics; Dogs / classification; Dogs / genetics; Gene Dosage; Genotype; Microarray Analysis; Microsatellite Repeats / genetics; Neoplasms / genetics; Neoplasms / veterinary; Phylogeny; Venereal Tumors, Veterinary / genetics; Wolves / genetics
TL;DR: The genetic and genomic patterns observed are typical of those expected of asexual pathogens, and the extended time since first origin may explain the many remarkable adaptations that have enabled this mammalian cell lineage to live as a unicellular pathogen. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors

Journal of Neuro-Oncology, 94(3), 333–349.

By: R. Thomas n, S. Duke n, H. Wang n, T. Breen n, R. Higgins*, K. Linder n, P. Ellis*, C. Langford* ...

author keywords: Comparative genomic hybridization; Canine; Brain tumor; Chromosome; Microarray
MeSH headings : Animals; Brain Neoplasms / genetics; Brain Neoplasms / pathology; Chromosome Aberrations; Chromosome Mapping; Chromosomes, Human, Pair 1; Chromosomes, Human, Pair 22; Cluster Analysis; Dogs; Female; Gene Expression Regulation, Neoplastic; Genome / genetics; Glioma / genetics; Glioma / pathology; Humans; In Situ Hybridization, Fluorescence; Male; Meningeal Neoplasms / genetics; Meningeal Neoplasms / pathology; Meningioma / genetics; Meningioma / pathology
TL;DR: A microarray-based comparative genomic hybridization analysis of 60 spontaneous canine intracranial tumors was performed to examine the degree to which dog and human patients exhibit aberrations of ancestrally related chromosome regions, consistent with a shared pathogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2008 journal article

A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis

CYTOGENETIC AND GENOME RESEARCH, 122(2), 110–121.

By: R. Thomas*, S. Duke, E. Karlsson *, A. Evans *, P. Ellis*, K. Lindblad-Toh *, C. Langford*, M. Breen*

MeSH headings : Animals; Chromosomes / genetics; Comparative Genomic Hybridization; Cytogenetics; Databases, Nucleic Acid; Dogs; Genome / genetics; In Situ Hybridization, Fluorescence; Neoplasms / genetics; Oligonucleotide Array Sequence Analysis
TL;DR: The dog genome sequence assembly is used to identify a framework panel of 2,097 bacterial artificial chromosome (BAC) clones, selected at intervals of approximately one megabase, which has enormous potential for aiding gene discovery through a comparative approach to molecular oncology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 article

A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog

JOURNAL OF HEREDITY, Vol. 98, pp. 474–484.

By: R. Thomas n, S. Duke n, S. Bloom n, T. Breen n, A. Young n, E. Feiste n, E. Seiser n, P. Tsai n ...

MeSH headings : Animals; Chromosome Mapping; Chromosomes, Artificial, Bacterial / genetics; Dogs / genetics; Genome; In Situ Hybridization, Fluorescence; Nucleic Acid Hybridization; Oligonucleotide Array Sequence Analysis; Sensitivity and Specificity
TL;DR: The value of a combined aCGH/FISH approach, together with a well-annotated dog genome assembly, in canine and comparative cancer studies is outlined. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

A novel canine lymphoma cell line: A translational and comparative model for lymphoma research

LEUKEMIA RESEARCH, 31(12), 1709–1720.

By: W. Kisseberth *, M. Nadella *, M. Breen n, R. Thomas n, S. Duke n, S. Murahari*, C. Kosarek*, W. Vernau* ...

author keywords: canine lymphoma; cell line; array comparative genomic hybridization; bioluminescent imaging; xenograft
MeSH headings : Animals; Biomedical Research; Cell Line, Tumor; Dogs; Immunophenotyping; Lymphoma / pathology; Mice; Mice, SCID; Neoplasm Transplantation; Transplantation, Heterologous
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-Cell lymphoma

VETERINARY PATHOLOGY, 44(4), 467–478.

By: S. Fosmire*, R. Thomas n, C. Jubala*, J. Wojcieszyn, V. Valli*, D. Getzy*, T. Smith*, L. Gardner* ...

author keywords: canines; cell cycle; non-Hodgkin's lymphoma; tumor suppressor genes
MeSH headings : Animals; Cyclin-Dependent Kinase Inhibitor p16 / genetics; Cyclin-Dependent Kinase Inhibitor p16 / metabolism; Dog Diseases / metabolism; Dogs; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / metabolism; Lymphoma, T-Cell / veterinary; Male; Retinoblastoma Protein / genetics; Retinoblastoma Protein / metabolism
TL;DR: The data show that p16 deletion or inactivation occurs almost exclusively in high-grade T-cell NHL; however, alternative pathways can generate functional phenotypes of Rb deficiency in low-grade Hodgkin's lymphoma and inHigh-grade B- cell NHL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors

GENOME RESEARCH, 15(12), 1831–1837.

By: R. Thomas n, A. Scott n, C. Langford*, S. Fosmire*, C. Jubala*, T. Lorentzen*, C. Hitte *, E. Karlsson ...

MeSH headings : Animals; Cell Line, Tumor; Chromosomes, Artificial, Bacterial / genetics; Cloning, Molecular; Dogs; Genomic Library; In Situ Hybridization, Fluorescence; Nucleic Acid Hybridization / methods; Osteosarcoma / genetics; Osteosarcoma / pathology
TL;DR: Examples of the varied applications of the small-scale genomic microarray resource to tumor cytogenetics, in combination with other molecular cytogenetic techniques are provided. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk

CANCER RESEARCH, 65(13), 5654–5661.

By: J. Modiano *, M. Breen  n, R. Burnett*, H. Parker *, S. Inusah*, R. Thomas n, P. Avery *, K. Lindblad-Toh * ...

MeSH headings : Animals; B-Lymphocytes / pathology; Dog Diseases / epidemiology; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Hodgkin Disease / epidemiology; Hodgkin Disease / genetics; Hodgkin Disease / immunology; Hodgkin Disease / pathology; Immunophenotyping; Lymphoproliferative Disorders / epidemiology; Lymphoproliferative Disorders / genetics; Lymphoproliferative Disorders / immunology; Lymphoproliferative Disorders / veterinary; Nucleic Acid Hybridization; Prevalence; T-Lymphocytes / pathology
TL;DR: Elevated risk for T-cell LPD seems to have arisen ancestrally and is retained in related breed groups, whereas increased risk for B-cell disease may stem from different risk factors, or combinations of risk factors arising during the process of breed derivation and selection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Nature, 438(7069), 803–819.

By: K. Lindblad-Toh, C. Wade, T. Mikkelsen, E. Karlsson, D. Jaffe, M. Kamal, M. Clamp, J. Chang ...

MeSH headings : Animals; Conserved Sequence / genetics; Dog Diseases / genetics; Dogs / classification; Dogs / genetics; Evolution, Molecular; Female; Genome / genetics; Genomics; Haplotypes / genetics; Humans; Hybridization, Genetic; Male; Mice; Mutagenesis / genetics; Polymorphism, Single Nucleotide / genetics; Rats; Short Interspersed Nucleotide Elements / genetics; Synteny / genetics
TL;DR: A high-quality draft genome sequence of the domestic dog is reported, together with a dense map of single nucleotide polymorphisms (SNPs) across breeds, to shed light on the structure and evolution of genomes and genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2005 journal article

Junctional epidermolysis bullosa in two domestic shorthair kittens

VETERINARY DERMATOLOGY, 16(1), 69–73.

By: Z. Alhaidari, T. Olivry n , A. Spadafora*, R. Thomas*, C. Perrin *, G. Meneguzzi *, J. Ortonne*

Contributors: Z. Alhaidari, T. Olivry n , A. Spadafora*, R. Thomas*, C. Perrin *, G. Meneguzzi *, J. Ortonne*

MeSH headings : Animals; Cat Diseases / pathology; Cats; Epidermolysis Bullosa, Junctional / pathology; Epidermolysis Bullosa, Junctional / ultrastructure; Epidermolysis Bullosa, Junctional / veterinary; Female; Fluorescent Antibody Technique, Indirect / veterinary; Immunoenzyme Techniques / veterinary; Laminin / biosynthesis; Male; Microscopy, Electron / veterinary
TL;DR: This article describes two cases of junctional epidermolysis bullosa in nonrelated kittens, both of which exhibited pinnal erosions, oral ulcerations and severe onychomadesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma

VETERINARY PATHOLOGY, 42(5), 618–632.

By: E. Dickerson*, R. Thomas n, S. Fosmire*, A. Lamerato-Kozicki*, . Bianco*, J. Wojcieszyn, M. Breen  n, S. Helfand*, J. Modiano *

author keywords: canine; endothelial cells; hemangiosarcoma; mutations; PTEN; tumor progression
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Dog Diseases / genetics; Dogs; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Hemangiosarcoma / genetics; Hemangiosarcoma / veterinary; Molecular Sequence Data; Mutation / genetics; PTEN Phosphohydrolase / chemistry; PTEN Phosphohydrolase / genetics; Sequence Homology, Amino Acid
TL;DR: The results document somatic point mutations or deletions encompassing the PTEN C-terminal domain in canine hemangiosarcoma that might provide cells a survival advantage within their microenvironment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2004 journal article

A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genomesequence

Mammalian Genome, 15(7), 544–551.

By: K. Comstock*, F. Lingaas *, E. Kirkness, C. Hitte *, R. Thomas*, M. Breen n, F. Galibert *, E. Ostrander *

MeSH headings : Animals; Chromosome Mapping; Chromosomes / ultrastructure; Chromosomes, Artificial, Bacterial; Crosses, Genetic; DNA / metabolism; DNA Primers / chemistry; Dogs; Gene Library; Genetic Linkage; Genetic Predisposition to Disease; Genome; Genome, Human; Genotype; Humans; Microsatellite Repeats; Models, Genetic; Polymorphism, Single Nucleotide; Species Specificity
TL;DR: This current mapping effort on CFA5 expands the degree to which initial findings of linkage in canine families can be followed by successful positional cloning efforts and increases the value of the human genome sequence for defining candidate genes. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
15. Life on Land (Web of Science)
Sources: Crossref, Web Of Science
Added: August 6, 2018

2004 journal article

An integrated 4249 marker FISH/RH map of the canine genome

BMC GENOMICS, 5.

By: M. Breen  n, C. Hitte *, T. Lorentzen*, R. Thomas n, E. Cadieu*, L. Sabacan*, A. Scott n, G. Evanno* ...

MeSH headings : Animals; Chromosome Mapping / methods; Chromosomes, Artificial, Bacterial; Dogs / genetics; Genetic Markers; Genome; Humans; In Situ Hybridization, Fluorescence; Microsatellite Repeats; Radiation Hybrid Mapping; Synteny
TL;DR: An integrated canine genome map that is both dense and accurate is constructed, allowing the identification of 79 conserved segments between the dog and human genomes, dramatically extending the length of most previously described CS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (Web of Science)
Source: Web Of Science
Added: August 6, 2018

journal article

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Lindblad-Toh, K. Genome Research, 25(11), 1634–1645.

By: I. Elvers, J. Turner-Maier, R. Swofford, M. Koltookian, J. Johnson, C. Stewart, C. Zhang, S. Schumacher ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Rivera, P. Genome Biology, 14(12).

By: E. Karlsson, S. Sigurdsson, E. Ivansson, R. Thomas, I. Elvers, J. Wright, C. Howald, N. Tonomura ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Kim, J. H. PLoS Genetics, 11(2).

By: N. Tonomura, I. Elvers, R. Thomas, K. Megquier, J. Turner-Maier, C. Howald, A. Sarver, R. Swofford ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma

Sakthikumar, S., Elvers, I., Kim, J., Arendt, M. L., Thomas, R., Turner-Maier, J., … Modiano, J. F. Cancer Research, 78(13), 3421–3431.

By: S. Sakthikumar, I. Elvers, J. Kim, M. Arendt, R. Thomas, J. Turner-Maier, R. Swofford, J. Johnson ...

Source: NC State University Libraries
Added: August 6, 2018

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