Rachael Thomas

The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone

SCIENCE ADVANCES, 9(9).

Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption

PLOS GENETICS, 19(4).

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

MOLECULAR CANCER RESEARCH, 19(5), 847–861.

A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans

LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.

Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers

VETERINARY SCIENCES, 7(3).

Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma

MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

CHROMOSOME RESEARCH, 25(2), 129–143.

Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 852–867.

A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity

CHROMOSOME RESEARCH, 23(4), 663–680.

Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo

PROSTATE, 74(13), 1251–1265.

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

Stem Cells and Development, 22(6), 951–963.

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas

Cancer, 118(23), 5878–5887.

CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies

LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.

Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts

Reproduction in Domestic Animals, 47, 418–419.

The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

GENES CHROMOSOMES & CANCER, 51(6), 569–578.

Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

CHROMOSOME RESEARCH, 19(6), 685–708.

Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart

GENES CHROMOSOMES & CANCER, 50(11), 859–874.

FLT3 mutations in canine acute lymphocytic leukemia

BMC CANCER, 11.

Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines

Veterinary and Comparative Oncology, 11(1), 30–50.

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis

CHROMOSOME RESEARCH, 17(7), 927–934.

Generation and characterization of novel canine malignant mast cell line CL1

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127(1-2), 114–124.

IDH1 and IDH2 hotspot mutations are not found in canine glioma

International Journal of Cancer, 127(1), 245–246.

Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

CHROMOSOME RESEARCH, 17(3), 365–377.

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

CHROMOSOME RESEARCH, 17(8), 987–1000.

ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER

EVOLUTION, 63(9), 2340–2349.

‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors

Journal of Neuro-Oncology, 94(3), 333–349.

A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis

CYTOGENETIC AND GENOME RESEARCH, 122(2), 110–121.

A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog

JOURNAL OF HEREDITY, Vol. 98, pp. 474–484.

A novel canine lymphoma cell line: A translational and comparative model for lymphoma research

LEUKEMIA RESEARCH, 31(12), 1709–1720.

Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-Cell lymphoma

VETERINARY PATHOLOGY, 44(4), 467–478.

Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors

GENOME RESEARCH, 15(12), 1831–1837.

Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk

CANCER RESEARCH, 65(13), 5654–5661.

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Nature, 438(7069), 803–819.

Junctional epidermolysis bullosa in two domestic shorthair kittens

VETERINARY DERMATOLOGY, 16(1), 69–73.

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma

VETERINARY PATHOLOGY, 42(5), 618–632.

A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genomesequence

Mammalian Genome, 15(7), 544–551.

An integrated 4249 marker FISH/RH map of the canine genome

BMC GENOMICS, 5.

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Lindblad-Toh, K. Genome Research, 25(11), 1634–1645.

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Rivera, P. Genome Biology, 14(12).

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Kim, J. H. PLoS Genetics, 11(2).

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma

Sakthikumar, S., Elvers, I., Kim, J., Arendt, M. L., Thomas, R., Turner-Maier, J., … Modiano, J. F. Cancer Research, 78(13), 3421–3431.