Works (49)

Updated: May 16th, 2023 05:01

2023 journal article

The dogs of Chernobyl: Demographic insights into populations inhabiting the nuclear exclusion zone

SCIENCE ADVANCES, 9(9).

Source: Web Of Science
Added: April 4, 2023

2023 journal article

Whole exome sequencing analysis of canine urothelial carcinomas without BRAF V595E mutation: Short in-frame deletions in BRAF and MAP2K1 suggest alternative mechanisms for MAPK pathway disruption

PLOS GENETICS, 19(4).

Sources: Web Of Science, ORCID
Added: May 15, 2023

2022 journal article

The AGMK1-9T7 cell model of neoplasia: Evolution of DNA copy-number aberrations and miRNA expression during transition from normal to metastatic cancer cells

PLOS ONE, 17(10).

By: A. Lewis*, R. Thomas, M. Breen, K. Peden, B. Teferedegne, G. Foseh, A. Motsinger-Reif, D. Rotroff, G. Lewis

Source: Web Of Science
Added: February 27, 2023

2021 journal article

Genomically Complex Human Angiosarcoma and Canine Hemangiosarcoma Establish Convergent Angiogenic Transcriptional Programs Driven by Novel Gene Fusions

MOLECULAR CANCER RESEARCH, 19(5), 847–861.

By: J. Kim*, K. Megquier*, R. Thomas, A. Sarver*, J. Song*, Y. Kim*, N. Cheng*, A. Schulte* ...

Source: Web Of Science
Added: June 10, 2021

2020 article

A comparative oncology approach to biomarker and drug discovery for cancer diagnosis and treatment in dogs and humans

LeBlanc, A. K., Mazcko, C. N., Breen, M., Thomas, R., & Thamm, D. H. (2020, August). CANCER RESEARCH, Vol. 80.

By: A. LeBlanc*, C. Mazcko*, M. Breen, R. Thomas & D. Thamm*

Source: Web Of Science
Added: March 8, 2021

2020 journal article

Development of a Genome-Wide Oligonucleotide Microarray Platform for Detection of DNA Copy Number Aberrations in Feline Cancers

VETERINARY SCIENCES, 7(3).

By: R. Thomas, J. Pontius*, L. Borst & M. Breen

author keywords: feline; cat; cancer; genomics; chromosome; comparative genomic hybridization (CGH)
Sources: Web Of Science, ORCID
Added: November 9, 2020

2020 article

Molecular mechanisms that activate convergent oncogenic pathway in genomically complex angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Schulte, A. J., Wang, C., … Modiano, J. F. (2020, August). CANCER RESEARCH, Vol. 80.

By: J. Kim*, K. Megquier*, A. Sarver*, R. Thomas, A. Schulte*, C. Wang*, I. Elvers*, E. Karlsson* ...

Source: Web Of Science
Added: March 8, 2021

2019 journal article

Comparative Genomics Reveals Shared Mutational Landscape in Canine Hemangiosarcoma and Human Angiosarcoma

MOLECULAR CANCER RESEARCH, 17(12), 2410–2421.

By: K. Megquier*, J. Turner-Maier*, R. Swofford*, J. Kim*, A. Sarver*, C. Wang*, S. Sakthikumar*, J. Johnson* ...

Sources: Web Of Science, ORCID
Added: December 30, 2019

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

author keywords: Histiocytic sarcoma; Chromothripsis; MMP9; Aurora kinase; Dendritic cell sarcoma
Source: Web Of Science
Added: September 30, 2019

2018 article

Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH, Vol. 78.

By: J. Kim, K. Megquier, A. Sarver, R. Thomas, C. Wang, I. Elvers, E. Karlsson, M. Breen, K. Lindblad-Toh, J. Modiano

Source: Web Of Science
Added: June 24, 2019

2017 journal article

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

By: J. Lim, S. Koh, R. Thomas, M. Breen & N. Olby

Sources: NC State University Libraries, Crossref, ORCID
Added: August 6, 2018

2017 journal article

Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

CHROMOSOME RESEARCH, 25(2), 129–143.

By: H. Mochizuki, R. Thomas, S. Moroff* & M. Breen

author keywords: Cancer; Comparative genomic hybridization; Digital PCR; Dog; Mastocytosis; Pug
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma

VETERINARY AND COMPARATIVE ONCOLOGY, 15(3), 852–867.

By: R. Thomas, Z. Demeter*, K. Kennedy, L. Borst, K. Singh*, V. Valli*, K. Le Boedec*, M. Breen

author keywords: BCL2; canine; comparative genomic hybridization; fluorescence in situ hybridization; follicular lymphoma; immunohistochemistry
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 journal article

A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity

CHROMOSOME RESEARCH, 23(4), 663–680.

By: R. Omeir*, R. Thomas, B. Teferedegne*, C. Williams n, G. Foseh*, J. Macauley*, L. Brinster*, J. Beren* ...

author keywords: Neoplastic transformation; Tumorigenicity; Canine chromosomes; Comparative genomic hybridization (CGH); Fluorescence in situ hybridization (FISH); Madin-Darby canine kidney (MDCK) cell line; CKB1-3T7 cell line
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Canine Prostate Cancer Cell Line (Probasco) Produces Osteoblastic Metastases In Vivo

PROSTATE, 74(13), 1251–1265.

author keywords: prostate cancer; osteoblastic metastases; canine; dog
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

CHROMOSOME RESEARCH, 22(3), 305–319.

By: R. Thomas, L. Borst, D. Rotroff, A. Motsinger-Reif, K. Lindblad-Toh*, J. Modiano*, M. Breen

author keywords: canine; chromosome; hemangiosarcoma; comparative genomic hybridization (CGH)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Growth Requirements and Chromosomal Instability of Induced Pluripotent Stem Cells Generated from Adult Canine Fibroblasts

Stem Cells and Development, 22(6), 951–963.

Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2013 article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Rotroff, D. M., Thomas, R., Breen, M., & Motsinger-Reif, A. A. (2013, December). PHARMACOGENOMICS, Vol. 14, pp. 1929–1931.

author keywords: cancer; canine model; chemotherapy; clinical trials
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas

Cancer, 118(23), 5878–5887.

By: A. Italiano*, C. Chen*, R. Thomas, M. Breen, F. Bonnet*, N. Sevenet*, M. Longy*, R. Maki*, J. Coindre*, C. Antonescu*

author keywords: angiosarcoma; p53; phosphoinositide-3-kinase; catalytic; alpha polypeptide; phosphatase and tensin homolog; complex karyotype
Source: Crossref
Added: June 6, 2020

2012 journal article

CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies

LEUKEMIA & LYMPHOMA, 53(7), 1390–1398.

By: D. Ito, A. Frantz, C. Williams, R. Thomas, R. Burnett, A. Avery, M. Breen, N. Mason, . Timothy D. O'Brien, J. Modiano

author keywords: Diffuse large B-cell lymphoma; CD40L; primary cell culture; canine model; cytotoxicity assay
Source: Web Of Science
Added: August 6, 2018

2012 conference paper

Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts

Reproduction in Domestic Animals, 47, 418–419.

By: S. Koh, S. Tsai, S. Bischoff, R. Thomas, J. Lim, M. Breen, N. Olby, J. Piedrahita

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

GENES CHROMOSOMES & CANCER, 51(6), 569–578.

By: A. Italiano*, R. Thomas, M. Breen, L. Zhang*, A. Crago*, S. Singer*, R. Khanin*, R. Maki* ...

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

CHROMOSOME RESEARCH, 19(6), 685–708.

By: S. Becker n, R. Thomas, V. Trifonov*, R. Wayne*, A. Graphodatsky* & M. Breen

author keywords: B chromosomes; fragile breakage model; breakpoint reuse theory; fluorescence in situ hybridization; phylogenetic; Canidae
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Characterization of Canine Osteosarcoma by Array Comparative Genomic Hybridization and RT-qPCR: Signatures of Genomic Imbalance in Canine Osteosarcoma Parallel the Human Counterpart

GENES CHROMOSOMES & CANCER, 50(11), 859–874.

By: A. Angstadt n, A. Motsinger-Reif, R. Thomas, W. Kisseberth*, C. Couto*, D. Duval*, D. Nielsen, J. Modiano*, M. Breen

Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

FLT3 mutations in canine acute lymphocytic leukemia

BMC CANCER, 11.

By: S. Suter, G. Small*, E. Seiser n, R. Thomas, M. Breen & K. Richards n

Source: Web Of Science
Added: August 6, 2018

2011 journal article

Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines

Veterinary and Comparative Oncology, 11(1), 30–50.

By: E. Seiser, R. Thomas, K. Richards n, M. Kathryn Kelley n, P. Moore*, S. Suter, M. Breen

author keywords: canine; cell line; comparative; lymphoid neoplasia; microarray; model
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas, E. Seiser, A. Motsinger-Reif, L. Borst, V. Valli*, K. Kelley n, S. Suter, D. Argyle* ...

author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 journal article

Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis

CHROMOSOME RESEARCH, 17(7), 927–934.

By: R. Thomas, C. Rebbeck*, A. Leroi*, A. Burt* & M. Breen

author keywords: comparative genomic hybridization (CGH); canine; transmissible venereal tumor; chromosome; microarray
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Generation and characterization of novel canine malignant mast cell line CL1

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 127(1-2), 114–124.

By: T. Lin*, R. Thomas, P. Tsai, M. Breen & C. London*

author keywords: Mast cell tumor; KIT; Cell line
Source: Web Of Science
Added: August 6, 2018

2009 journal article

IDH1 and IDH2 hotspot mutations are not found in canine glioma

International Journal of Cancer, 127(1), 245–246.

By: Z. Reitman*, N. Olby, C. Mariani, R. Thomas, M. Breen, D. Bigner*, R. McLendon*, H. Yan*

Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2009 journal article

Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

CHROMOSOME RESEARCH, 17(3), 365–377.

By: R. Thomas, H. Wang, P. Tsai, C. Langford*, S. Fosmire*, C. Jubala*, D. Getzy*, G. Cutter*, J. Modiano*, M. Breen

author keywords: microarray; comparative genomic hybridization (CGH); canine; osteosarcoma; chromosome
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

CHROMOSOME RESEARCH, 17(8), 987–1000.

By: R. Thomas, V. Valli*, P. Ellis*, J. Bell*, E. Karlsson*, J. Cullen, K. Lindblad-Toh*, C. Langford*, M. Breen

author keywords: microarray; comparative genomic hybridization (CGH); feline; sarcoma; chromosome
Source: Web Of Science
Added: August 6, 2018

2009 journal article

ORIGINS AND EVOLUTION OF A TRANSMISSIBLE CANCER

EVOLUTION, 63(9), 2340–2349.

By: C. Rebbeck*, R. Thomas, M. Breen, A. Leroi* & A. Burt*

author keywords: Chromosomal evolution; evolutionary genomics; genetic variation; molecular evolution; population genetics; sex
Source: Web Of Science
Added: August 6, 2018

2009 journal article

‘Putting our heads together’: insights into genomic conservation between human and canine intracranial tumors

Journal of Neuro-Oncology, 94(3), 333–349.

By: R. Thomas, S. Duke n, H. Wang, T. Breen n, R. Higgins*, K. Linder, P. Ellis*, C. Langford* ...

author keywords: Comparative genomic hybridization; Canine; Brain tumor; Chromosome; Microarray
Sources: Web Of Science, Crossref, ORCID
Added: August 6, 2018

2008 journal article

A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis

CYTOGENETIC AND GENOME RESEARCH, 122(2), 110–121.

By: R. Thomas, S. Duke, E. Karlsson*, A. Evans*, P. Ellis*, K. Lindblad-Toh*, C. Langford*, M. Breen

Source: Web Of Science
Added: August 6, 2018

2007 article

A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog

JOURNAL OF HEREDITY, Vol. 98, pp. 474–484.

By: R. Thomas, S. Duke, S. Bloom, T. Breen, A. Young, E. Feiste, E. Seiser, P. Tsai ...

Source: Web Of Science
Added: August 6, 2018

2007 journal article

A novel canine lymphoma cell line: A translational and comparative model for lymphoma research

LEUKEMIA RESEARCH, 31(12), 1709–1720.

By: W. Kisseberth*, M. Nadella*, M. Breen, R. Thomas, S. Duke n, S. Murahari*, C. Kosarek*, W. Vernau* ...

author keywords: canine lymphoma; cell line; array comparative genomic hybridization; bioluminescent imaging; xenograft
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-Cell lymphoma

VETERINARY PATHOLOGY, 44(4), 467–478.

By: S. Fosmire*, R. Thomas, C. Jubala*, J. Wojcieszyn*, V. Valli*, D. Getzy*, T. Smith*, L. Gardner* ...

author keywords: canines; cell cycle; non-Hodgkin's lymphoma; tumor suppressor genes
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors

GENOME RESEARCH, 15(12), 1831–1837.

By: R. Thomas, A. Scott, C. Langford*, S. Fosmire*, C. Jubala*, T. Lorentzen*, C. Hitte*, E. Karlsson* ...

Source: Web Of Science
Added: August 6, 2018

2005 journal article

Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk

CANCER RESEARCH, 65(13), 5654–5661.

By: J. Modiano*, M. Breen n, R. Burnett*, H. Parker*, S. Inusah*, R. Thomas, P. Avery*, K. Lindblad-Toh* ...

Source: Web Of Science
Added: August 6, 2018

2005 journal article

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Nature, 438(7069), 803–819.

By: K. Lindblad-Toh*, C. Wade*, T. Mikkelsen*, E. Karlsson*, D. Jaffe*, M. Kamal*, M. Clamp*, J. Chang* ...

Sources: Web Of Science, Crossref
Added: August 6, 2018

2005 journal article

Junctional epidermolysis bullosa in two domestic shorthair kittens

VETERINARY DERMATOLOGY, 16(1), 69–73.

By: Z. Alhaidari*, T. Olivry, A. Spadafora*, R. Thomas, C. Perrin*, G. Meneguzzi*, J. Ortonne*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2005 journal article

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma

VETERINARY PATHOLOGY, 42(5), 618–632.

By: E. Dickerson*, R. Thomas, S. Fosmire*, A. Lamerato-Kozicki*, . Bianco*, J. Wojcieszyn*, M. Breen n, S. Helfand*, J. Modiano*

author keywords: canine; endothelial cells; hemangiosarcoma; mutations; PTEN; tumor progression
Source: Web Of Science
Added: August 6, 2018

2004 journal article

A high-resolution comparative map of canine Chromosome 5q14.3-q33 constructed utilizing the 1.5x canine genomesequence

Mammalian Genome, 15(7), 544–551.

By: K. Comstock*, F. Lingaas*, E. Kirkness*, C. Hitte*, R. Thomas, M. Breen, F. Galibert*, E. Ostrander*

Sources: Crossref, Web Of Science
Added: August 6, 2018

2004 journal article

An integrated 4249 marker FISH/RH map of the canine genome

BMC GENOMICS, 5.

By: M. Breen n, C. Hitte*, T. Lorentzen*, R. Thomas, E. Cadieu*, L. Sabacan*, A. Scott, G. Evanno* ...

Source: Web Of Science
Added: August 6, 2018

journal article

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Lindblad-Toh, K. Genome Research, 25(11), 1634–1645.

By: I. Elvers, J. Turner-Maier, R. Swofford, M. Koltookian, J. Johnson, C. Stewart, C. Zhang, S. Schumacher ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Rivera, P. Genome Biology, 14(12).

By: E. Karlsson, S. Sigurdsson, E. Ivansson, R. Thomas, I. Elvers, J. Wright, C. Howald, N. Tonomura ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Kim, J. H. PLoS Genetics, 11(2).

By: N. Tonomura, I. Elvers, R. Thomas, K. Megquier, J. Turner-Maier, C. Howald, A. Sarver, R. Swofford ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma

Sakthikumar, S., Elvers, I., Kim, J., Arendt, M. L., Thomas, R., Turner-Maier, J., … Modiano, J. F. Cancer Research, 78(13), 3421–3431.

By: S. Sakthikumar, I. Elvers, J. Kim, M. Arendt, R. Thomas, J. Turner-Maier, R. Swofford, J. Johnson ...

Source: NC State University Libraries
Added: August 6, 2018