Works (39)

2019 journal article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

CHROMOSOME RESEARCH, 27(3), 179–202.

Source: Web Of Science
Added: September 30, 2019

2018 article

Mutational and transcriptomic profiling identify distinct angiogenic and inflammatory subtypes of angiosarcoma

Kim, J. H., Megquier, K., Sarver, A. L., Thomas, R., Wang, C., Elvers, I., … Modiano, J. F. (2018, July). CANCER RESEARCH.

By: J. Kim, K. Megquier, A. Sarver, R. Thomas, C. Wang, I. Elvers, E. Karlsson, M. Breen, K. Lindblad-Toh, J. Modiano

Source: Web Of Science
Added: June 24, 2019

2017 journal article

Evaluation of gene expression and DNA copy number profiles of adipose tissue-derived stromal cells and consecutive neurosphere-like cells generated from dogs with naturally occurring spinal cord injury

American Journal of Veterinary Research, 78(3), 371–380.

By: J. Lim, S. Koh, R. Thomas, M. Breen & N. Olby

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Genomic profiling of canine mast cell tumors identifies DNA copy number aberrations associated with KIT mutations and high histological grade

Chromosome Research, 25(2), 129–143.

By: H. Mochizuki, R. Thomas, S. Moroff & M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Integrated immunohistochemical and DNA copy number profiling analysis provides insight into the molecular pathogenesis of canine follicular lymphoma

Veterinary and Comparative Oncology, 15(3), 852–867.

By: R. Thomas, Z. Demeter, K. Kennedy, L. Borst, K. Singh, V. Valli, K. Le Boedec, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

A novel canine kidney cell line model for the evaluation of neoplastic development: karyotype evolution associated with spontaneous immortalization and tumorigenicity

Chromosome Research, 23(4), 663–680.

By: R. Omeir, R. Thomas, B. Teferedegne, C. Williams, G. Foseh, J. Macauley, L. Brinster, J. Beren ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Canine prostate cancer cell line (Probasco) produces osteoblastic metastases invivo

Prostate, 74(13), 1251–1265.

By: J. Simmons, W. Dirksen, B. Hildreth, C. Dorr, C. Williams, R. Thomas, M. Breen, R. Toribio, T. Rosol

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

Chromosome Research, 22(3), 305–319.

By: R. Thomas, L. Borst, D. Rotroff, A. Motsinger-Reif, K. Lindblad-Toh, J. Modiano, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Growth requirements and chromosomal instability of induced pluripotent stem cells generated from adult canine fibroblasts

Stem Cells and Development, 22(6), 951–963.

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine

Pharmacogenomics, 14(16), 1929–1931.

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Reading between the lines: Molecular characterization of five widely used canine lymphoid tumour cell lines

Veterinary and Comparative Oncology, 11(1), 30–50.

By: E. Seiser, R. Thomas, K. Richards, M. Kelley, P. Moore, S. Suter, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

CD40 ligand is necessary and sufficient to support primary diffuse large B-cell lymphoma cells in culture: a tool for in vitro preclinical studies with primary B-cell malignancies

Leukemia & Lymphoma, 53(7), 1390–1398.

By: D. Ito, A. Frantz, C. Williams, R. Thomas, R. Burnett, A. Avery, M. Breen, N. Mason, T. O'Brien, J. Modiano

Source: NC State University Libraries
Added: August 6, 2018

2012 conference paper

Generation and characterization of induced pluripotent stem cells (iPS) from adult canine fibroblasts

In Reproduction in Domestic Animals (Vol. 47, pp. 418–419).

By: S. Koh, S. Tsai, S. Bischoff, R. Thomas, J. Lim, M. Breen, N. Olby, J. Piedrahita

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification

Genes, Chromosomes and Cancer, 51(6), 569–578.

By: A. Italiano, R. Thomas, M. Breen, L. Zhang, A. Crago, S. Singer, R. Khanin, R. Maki ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Anchoring the dog to its relatives reveals new evolutionary breakpoints across 11 species of the Canidae and provides new clues for the role of B chromosomes

Chromosome Research, 19(6), 685–708.

By: S. Becker, R. Thomas, V. Trifonov, R. Wayne, A. Graphodatsky & M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: Signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart

Genes, Chromosomes and Cancer, 50(11), 859–874.

By: A. Angstadt, A. Motsinger-Reif, R. Thomas, W. Kisseberth, C. Couto, D. Duval, D. Nielsen, J. Modiano, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

FLT3 mutations in canine acute lymphocytic leukemia

BMC Cancer, 11.

By: S. Suter, G. Small, E. Seiser, R. Thomas, M. Breen & K. Richards

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas, E. Seiser, A. Motsinger-Reif, L. Borst, V. Valli, K. Kelley, S. Suter, D. Argyle ...

Source: NC State University Libraries
Added: August 6, 2018

2010 personal communication

IDH1 and IDH2 hotspot mutations are not found in canine glioma

International Journal of Cancer.

By: Z. Reitman, N. Olby, C. Mariani, R. Thomas, M. Breen, D. Bigner, R. McLendon, H. Yan

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

'Putting our heads together': insights into genomic conservation between human and canine intracranial tumors

Journal of Neuro-Oncology, 94(3), 333–349.

By: R. Thomas, S. Duke, H. Wang, T. Breen, R. Higgins, K. Linder, P. Ellis, C. Langford ...

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Extensive conservation of genomic imbalances in canine transmissible venereal tumors (CTVT) detected by microarray-based CGH analysis

Chromosome Research, 17(7), 927–934.

By: R. Thomas, C. Rebbeck, A. Leroi, A. Burt & M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Generation and characterization of novel canine malignant mast cell line CL1

Veterinary Immunology and Immunopathology, 127(1-2), 114–124.

By: T. Lin, R. Thomas, P. Tsai, M. Breen & C. London

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Influence of genetic background on tumor karyotypes: Evidence for breed-associated cytogenetic aberrations in canine appendicular osteosarcoma

Chromosome Research, 17(3), 365–377.

By: R. Thomas, H. Wang, P. Tsai, C. Langford, S. Fosmire, C. Jubala, D. Getzy, G. Cutter, J. Modiano, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Microarray-based cytogenetic profiling reveals recurrent and subtype-associated genomic copy number aberrations in feline sarcomas

Chromosome Research, 17(8), 987–1000.

By: R. Thomas, V. Valli, P. Ellis, J. Bell, E. Karlsson, J. Cullen, K. Lindblad-Toh, C. Langford, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Origins and evolution of a transmissible cancer

Evolution, 63(9), 2340–2349.

By: C. Rebbeck, R. Thomas, M. Breen, A. Leroi & A. Burt

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

A genome assembly-integrated dog 1 Mb BAC microarray: a cytogenetic resource for canine cancer studies and comparative genomic analysis

Cytogenetic and Genome Research, 122(2), 110–121.

By: R. Thomas, S. Duke, E. Karlsson, A. Evans, P. Ellis, K. Lindblad-Toh, C. Langford, M. Breen

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

A cytogenetically characterized, genome-anchored 10-Mb BAC set and CGH array for the domestic dog

Journal of Heredity, 98(5), 474–484.

By: R. Thomas, S. Duke, S. Bloom, T. Breen, A. Young, E. Feiste, E. Seiser, P. Tsai ...

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

A novel canine lymphoma cell line: A translational and comparative model for lymphoma research

Leukemia Research, 31(12), 1709–1720.

By: W. Kisseberth, M. Nadella, M. Breen, R. Thomas, S. Duke, S. Murahari, C. Kosarek, W. Vernau ...

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Inactivation of the p16 cyclin-dependent kinase inhibitor in high-grade canine non-Hodgkin's T-Cell lymphoma

Veterinary Pathology, 44(4), 467–478.

By: S. Fosmire, R. Thomas, C. Jubala, J. Wojcieszyn, V. Valli, D. Getzy, T. Smith, L. Gardner ...

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Construction of a 2-Mb resolution BAC microarray for CGH analysis of canine tumors

Genome Research, 15(12), 1831–1837.

By: R. Thomas, A. Scott, C. Langford, S. Fosmire, C. Jubala, T. Lorentzen, C. Hitte, E. Karlsson ...

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Distinct B-cell and T-cell lymphoproliferative disease prevalence among dog breeds indicates heritable risk

Cancer Research, 65(13), 5654–5661.

By: J. Modiano, M. Breen, R. Burnett, H. Parker, S. Inusah, R. Thomas, P. Avery, K. Lindblad-Toh ...

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Genome sequence, comparative analysis and haplotype structure of the domestic dog

Nature, 438(7069), 803–819.

By: M. Breen & R. Thomas

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Junctional epidermolysis bullosa in two domestic shorthair kittens

Veterinary Dermatology, 16(1), 69–73.

By: Z. Alhaidari, T. Olivry, A. Spadafora, R. Thomas, C. Perrin, G. Meneguzzi, J. Ortonne

Source: NC State University Libraries
Added: August 6, 2018

2005 journal article

Mutations of phosphatase and tensin homolog deleted from chromosome 10 in canine hemangiosarcoma

Veterinary Pathology, 42(5), 618–632.

By: E. Dickerson, R. Thomas, S. Fosmire, A. Lamerato-Kozicki, S. Bianco, J. Wojcieszyn, M. Breen, S. Helfand, J. Modiano

Source: NC State University Libraries
Added: August 6, 2018

2004 journal article

An integrated 4249 marker FISH/RH map of the canine genome

BMC Genomics, 5(Sep 13 2004).

By: M. Breen, C. Hitte, T. Lorentzen, R. Thomas, E. Cadieu, L. Sabacan, A. Scott, G. Evanno ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Exome sequencing of lymphomas from three dog breeds reveals somatic mutation patterns reflecting genetic background

Elvers, I., Turner-Maier, J., Swofford, R., Koltookian, M., Johnson, J., Stewart, C., … Lindblad-Toh, K. Genome Research, 25(11), 1634–1645.

By: I. Elvers, J. Turner-Maier, R. Swofford, M. Koltookian, J. Johnson, C. Stewart, C. Zhang, S. Schumacher ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide analyses implicate 33 loci in heritable dog osteosarcoma, including regulatory variants near CDKN2A/B

Karlsson, E. K., Sigurdsson, S., Ivansson, E., Thomas, R., Elvers, I., Wright, J., … Rivera, P. Genome Biology, 14(12).

By: E. Karlsson, S. Sigurdsson, E. Ivansson, R. Thomas, I. Elvers, J. Wright, C. Howald, N. Tonomura ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

Genome-wide association study identifies shared risk loci common to two malignancies in golden retrievers

Tonomura, N., Elvers, I., Thomas, R., Megquier, K., Turner-Maier, J., Howald, C., … Kim, J. H. PLoS Genetics, 11(2).

By: N. Tonomura, I. Elvers, R. Thomas, K. Megquier, J. Turner-Maier, C. Howald, A. Sarver, R. Swofford ...

Source: NC State University Libraries
Added: August 6, 2018

journal article

SETD2 is recurrently mutated in whole-exome sequenced canine osteosarcoma

Sakthikumar, S., Elvers, I., Kim, J., Arendt, M. L., Thomas, R., Turner-Maier, J., … Modiano, J. F. Cancer Research, 78(13), 3421–3431.

By: S. Sakthikumar, I. Elvers, J. Kim, M. Arendt, R. Thomas, J. Turner-Maier, R. Swofford, J. Johnson ...

Source: NC State University Libraries
Added: August 6, 2018