Ryan Tam

Works (2)

Updated: August 29th, 2023 05:01

2023 journal article

Profiling transcriptomic responses of human stem cell-derived medium spiny neuron-like cells to exogenous phasic and tonic neurotransmitters

MOLECULAR AND CELLULAR NEUROSCIENCE, 126.

By: R. Tam n & A. Keung n 

author keywords: Human pluripotent stem cells; Medium spiny neuron; Tonic neuromodulation; Neurotransmitter; Gene desensitization; Transcriptome
TL;DR: The results here suggest future optimizations of human stem cell derived neurons to increase their in vivo relevance and the biological insights that can be garnered from these models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023

2022 journal article

Human Pluripotent Stem Cell-Derived Medium Spiny Neuron-like Cells Exhibit Gene Desensitization

CELLS, 11(9).

By: R. Tam n & A. Keung n 

author keywords: dopamine; gene desensitization; acute and chronic; RNA-seq; human embryonic stem cell; medium spiny neuron
MeSH headings : Dopamine; Humans; Neurites; Neurons / physiology; Pluripotent Stem Cells; Receptors, Dopamine
TL;DR: The dynamic responses of human stem cell-derived medium spiny neuron-like cells (hMSN- like cells) to dopamine are mapped and it is shown that these human neurons can reflect and capture cellular desensitization to chronic versus acute administration of dopamine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 23, 2022

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