Shoeb Ahmed

Works (6)

Updated: September 9th, 2024 08:15

2019 journal article

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation

SCIENCE SIGNALING, 12(584).

By: K. Tiruthani n, A. Mischler n, S. Ahmed*, J. Mahinthakumar  n, J. Haugh n  & B. Rao n 

Contributors: K. Tiruthani n, A. Mischler n, S. Ahmed*, J. Mahinthakumar  n, J. Haugh n  & B. Rao n 

MeSH headings : Animals; Biosensing Techniques; Cell Line; Endocytosis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Mice; Microscopy, Fluorescence; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Phosphorylation / genetics; src Homology Domains
TL;DR: The authors used two different mutagenesis and screening approaches to engineer new biosensors, mSH2 and SPY992, that exhibited greater specificity for EGFR Tyr992 and more accurately reported EGFR signaling kinetics, and could be extended to generate phospho-specific biosensor for various targets. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 24, 2019

2018 journal article

Effect of micro-roughness shapes on jet impingement heat transfer and fin-effectiveness

International Journal of Heat and Mass Transfer, 132, 80–95.

By: P. Singh n, M. Zhang *, S. Ahmed  n, K. Ramakrishnan n & S. Ekkad n 

Contributors: P. Singh n, M. Zhang *, S. Ahmed n, K. Ramakrishnan n & S. Ekkad n 

author keywords: Convective heat transfer; Pin fins; Jet impingement; Fin effectiveness; Thermal hydraulic performance
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: March 11, 2019

2014 journal article

Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

MOLECULAR SYSTEMS BIOLOGY, 10(1).

By: S. Ahmed n, K. Grant n, L. Edwards  n, A. Rahman n, M. Cirit n, M. Goshe n, J. Haugh n 

author keywords: growth factor receptors; mitogen-activated protein kinases; negative feedback; nucleocytoplasmic shuttling; mathematical model
MeSH headings : Active Transport, Cell Nucleus; Animals; Extracellular Signal-Regulated MAP Kinases / chemistry; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Kinetics; Mice; Models, Theoretical; NIH 3T3 Cells; Phosphorylation; Protein Transport / genetics; Receptors, Growth Factor / genetics; Signal Transduction / genetics
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2012 journal article

Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism

JOURNAL OF CELL BIOLOGY, 197(1), 105–114.

By: E. Welf n, S. Ahmed n, H. Johnson n, A. Melvin n & J. Haugh n 

MeSH headings : Animals; Cell Movement; Cells, Cultured; Fibroblasts / cytology; Fibroblasts / enzymology; Fibroblasts / metabolism; Mice; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / metabolism; Phosphoinositide-3 Kinase Inhibitors; Signal Transduction / drug effects
TL;DR: Migrating fibroblasts reorient directionality by PI3K-dependent branching and pivoting of protrusions, a mechanism that allows fibro Blasts to align with an external chemotactic gradient. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2011 journal article

Poly(vinylmethylsiloxane) Elastomer Networks as Functional Materials for Cell Adhesion and Migration Studies

BIOMACROMOLECULES, 12(4), 1265–1271.

By: S. Ahmed n, H. Yang n, A. Ozcam n, K. Efimenko n , M. Weiger n, J. Genzer n , J. Haugh n 

MeSH headings : Amino Acid Sequence; Animals; Cell Adhesion; Cell Movement; Mice; Microscopy, Fluorescence; Molecular Sequence Data; NIH 3T3 Cells; Oligopeptides / chemistry; Polyvinyls / chemistry; Siloxanes / chemistry
TL;DR: These experiments show that a peptide containing the synergy sequence of fibronectin (PHSRN) in addition to RGD promotes more productive cell migration without markedly enhancing cell adhesion strength. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Directional Persistence of Cell Migration Coincides with Stability of Asymmetric Intracellular Signaling

BIOPHYSICAL JOURNAL, 98(1), 67–75.

By: M. Weiger n, S. Ahmed n, E. Welf n & J. Haugh n 

MeSH headings : Animals; Cell Movement / physiology; Computer Simulation; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases; Signal Transduction / physiology
TL;DR: Analysis of phosphoinositide 3-kinase signaling in randomly migrating fibroblasts shows that hot spots of intense signaling coincide with localized cell protrusion and endure with characteristic lifetimes that correspond to those of cell migration persistence, and shows that distant hot spots are dynamically and stochastically coupled. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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