Steven A. Rogers

Works (12)

Updated: April 25th, 2025 15:04

2012 article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

Stowe, S. D., Tucker, A. T., Thompson, R., Piper, A., Richards, J. J., Rogers, S. A., … Cavanagh, J. (2012, January 31). Drug and Chemical Toxicology.

By: S. Stowe n, A. Tucker*, R. Thompson*, A. Piper*, J. Richards*, S. Rogers*, L. Mathies n, C. Melander*, J. Cavanagh*

author keywords: 2-aminoimidazole; adjuvant; biofilm; Caenorhabditis elegans; toxicity; Toxicity of 2-aminoimidazole; antibiofilm agents
MeSH headings : Adjuvants, Pharmaceutic / toxicity; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / toxicity; Biofilms / drug effects; Caenorhabditis elegans; Cell Line; Dose-Response Relationship, Drug; Environmental Exposure; Fertility / drug effects; Humans; Imidazoles / pharmacology; Imidazoles / toxicity; Keratinocytes / metabolism; Tetrazolium Salts; Thiazoles; Toxicity Tests
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Nanoparticles: synthesis and applications
TL;DR: The most effective antibiofilm compound had significant effects when used in conjunction with several standard antibiotics against resistant bacteria and was found to maintain the same low level of toxicity as when acting alone, bolstering its candidacy for further testing as an adjuvant. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper

Worthington, R. J., Rogers, S. A., Huigens, R. W., Melander, C., & Ritchie, D. F. (2012, June 13). Plant Disease, Vol. 96, pp. 1638–1644.

By: R. Worthington, S. Rogers*, R. Huigens*, C. Melander* & D. Ritchie n 

topics (OpenAlex): Plant Pathogenic Bacteria Studies; Plant-Microbe Interactions and Immunity; Plant Pathogens and Fungal Diseases
TL;DR: A small molecule additive, a member of the 2-aminoimidazole (2AI) group that is an analogue of the marine sponge natural product oroidin that suppresses resistance of Xanthomonas euvesicatoria to copper and decreases biofilm formation in an in vitro system is reported. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2010 journal article

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

Organic & Biomolecular Chemistry, 8(12), 2814–2822.

By: Z. Su, S. Rogers, W. McCall, A. Smith, S. Ravishankar, T. Mullikin, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 article

Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents

Rogers, S. A., Bero, J. D., & Melander, C. (2010, January 4). ChemBioChem.

By: S. Rogers n, J. Bero n & C. Melander n

author keywords: aminoimidazoles; biofilms; MDRAB; MRSA; multidrug-resistant bacteria
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Antifungal Agents / chemical synthesis; Antifungal Agents / chemistry; Antifungal Agents / pharmacology; Biofilms / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antifungal resistance and susceptibility
TL;DR: This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa, a multidrug‐resistant strain of Acinetobacter baumannii, a methicillin‐resistant Staphylococcus aureus strain, and the yeast Candida albicans and Cryptococcus neoformans. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Modulating the development of E. coli biofilms with 2-aminoimidazoles

Reed, C. S., Huigens, R. W., Rogers, S. A., & Melander, C. (2010, August 21). Bioorganic & Medicinal Chemistry Letters.

By: C. Reed n, R. Huigens n, S. Rogers n & C. Melander n

author keywords: 2-Aminoimidazoles; E. coli; Biofilms
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Drug Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Hemolysis / drug effects; Humans; Imidazoles / chemical synthesis; Imidazoles / pharmacology; In Vitro Techniques; Structure-Activity Relationship
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial agents and applications; Antimicrobial Peptides and Activities
TL;DR: The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported, with the best inhibitor inhibiting biofilm development with an IC(50) of 13μM. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

Rogers, S. A., Huigens, R. W., Cavanagh, J., & Melander, C. (2010, March 9). Antimicrobial Agents and Chemotherapy.

By: S. Rogers n, R. Huigens n, J. Cavanagh n & C. Melander n

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Calcium Chloride / pharmacology; Chlorides / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial; Drug Resistance, Multiple; Drug Synergism; Enterococcus faecium / drug effects; Erythrocytes / drug effects; Escherichia coli / drug effects; Humans; Imidazoles / chemistry; Imidazoles / pharmacology; Magnesium / pharmacology; Manganese Compounds / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Novobiocin / pharmacology; Staphylococcus epidermidis / drug effects; Tobramycin / pharmacology; Triazoles / pharmacology
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial agents and applications; Antimicrobial Peptides and Activities
TL;DR: The synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilmms is reported. (via Semantic Scholar)
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Source: Web Of Science
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2010 journal article

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

Organic & Biomolecular Chemistry, 8(17), 3857–3859.

By: S. Rogers, D. Whitehead, T. Mullikin & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 article

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents

Rogers, S. A., Lindsey, E. A., Whitehead, D. C., Mullikin, T., & Melander, C. (2010, December 23). Bioorganic & Medicinal Chemistry Letters.

By: S. Rogers n, E. Lindsey n, D. Whitehead n, T. Mullikin n & C. Melander n

author keywords: Biofilms; Anti-biofilm; Antibiotic; 2-Aminoimidazole; Menthyl carbamate
MeSH headings : Animals; Anti-Infective Agents / chemical synthesis; Anti-Infective Agents / chemistry; Anti-Infective Agents / pharmacology; Biofilms / drug effects; Carbamates / chemistry; Erythrocytes / drug effects; Hemolysis; Imidazoles / chemistry; Microbial Sensitivity Tests; Sheep
topics (OpenAlex): Antimicrobial Peptides and Activities; Bacterial biofilms and quorum sensing; Antimicrobial agents and applications
TL;DR: The successful marriage of structural features from 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilm modulators. (via Semantic Scholar)
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2009 article

A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism

Rogers, S. A., Huigens, R. W., III, & Melander, C. (2009, July 2). Journal of the American Chemical Society.

By: S. Rogers n, R. Huigens n & C. Melander n

MeSH headings : Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Dose-Response Relationship, Drug; Gram-Positive Bacteria / drug effects; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; Zinc / chemistry; Zinc / pharmacology
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antimicrobial agents and applications
TL;DR: Mechanistic studies showed that the activity of a lead 2-aminobenzimidazole is Zn(II)-dependent, potentially via a direct zinc-chelating mechanism. (via Semantic Scholar)
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2009 article

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

Huigens, R. W., III, Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009, January 1). Organic & Biomolecular Chemistry.

By: R. Huigens n, S. Rogers n, A. Steinhauer n & C. Melander n

MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Biofilms / drug effects; Imidazoles / chemistry; Pseudomonas aeruginosa / drug effects; Small Molecule Libraries / chemical synthesis; Staphylococcus aureus / drug effects; Triazoles / chemical synthesis
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial Peptides and Activities; Antimicrobial agents and applications
TL;DR: A chemically diverse library of TAGE-triazole conjugates synthesized utilizing click chemistry on the TAGE scaffold demonstrated the most potent inhibitory effect against Staphylococcus aureus biofilm formation that has been displayed by any 2-aminoimidazole derivative. (via Semantic Scholar)
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2009 article

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Huigens, R. W., Reyes, S., Reed, C. S., Bunders, C., Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009, December 7). Bioorganic & Medicinal Chemistry.

By: R. Huigens n, S. Reyes n, C. Reed n, C. Bunders n, S. Rogers n, A. Steinhauer n, C. Melander n

author keywords: 2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Resistance, Multiple, Bacterial; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Conformation; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
topics (OpenAlex): Synthesis and biological activity; Phenothiazines and Benzothiazines Synthesis and Activities; Antimicrobial Peptides and Activities
TL;DR: These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (via Semantic Scholar)
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Source: Web Of Science
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2008 article

Tandem dispersion and killing of bacteria from a biofilm

Rogers, S. A., Krayer, M., Lindsey, J. S., & Melander, C. (2008, December 10). Organic & Biomolecular Chemistry, Vol. 7, pp. 603–606.

By: S. Rogers n, M. Krayer n, J. Lindsey n  & C. Melander n

MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / growth & development; Biofilms; Microbial Viability / drug effects; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Triazoles / chemistry; Triazoles / pharmacology
topics (OpenAlex): Photodynamic Therapy Research Studies; Nanoplatforms for cancer theranostics; Antifungal resistance and susceptibility
TL;DR: The combined effects of biofilm dispersion with a 2-aminoimidazole-triazole conjugate and bactericidal activity with a photodynamic inactivation agent suggest a novel combination therapy for treating diverse microbial infections. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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