Works (12)
Updated: July 25th, 2023 21:16
2012 journal article
Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems
DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310–315.
author keywords: 2-aminoimidazole; adjuvant; biofilm; Caenorhabditis elegans; toxicity; Toxicity of 2-aminoimidazole; antibiofilm agents
MeSH headings : Adjuvants, Pharmaceutic / toxicity; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / toxicity; Biofilms / drug effects; Caenorhabditis elegans; Cell Line; Dose-Response Relationship, Drug; Environmental Exposure; Fertility / drug effects; Humans; Imidazoles / pharmacology; Imidazoles / toxicity; Keratinocytes / metabolism; Tetrazolium Salts; Thiazoles; Toxicity Tests
TL;DR:
The most effective antibiofilm compound had significant effects when used in conjunction with several standard antibiotics against resistant bacteria and was found to maintain the same low level of toxicity as when acting alone, bolstering its candidacy for further testing as an adjuvant.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper
PLANT DISEASE, 96(11), 1638–1644.
TL;DR:
A small molecule additive, a member of the 2-aminoimidazole (2AI) group that is an analogue of the marine sponge natural product oroidin that suppresses resistance of Xanthomonas euvesicatoria to copper and decreases biofilm formation in an in vitro system is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity
Organic & Biomolecular Chemistry, 8(12), 2814–2822.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents
CHEMBIOCHEM, 11(3), 396–410.
author keywords: aminoimidazoles; biofilms; MDRAB; MRSA; multidrug-resistant bacteria
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Antifungal Agents / chemical synthesis; Antifungal Agents / chemistry; Antifungal Agents / pharmacology; Biofilms / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
TL;DR:
This class of small molecules was found to modulate the biofilm activity of Pseudomonas aeruginosa, a multidrug‐resistant strain of Acinetobacter baumannii, a methicillin‐resistant Staphylococcus aureus strain, and the yeast Candida albicans and Cryptococcus neoformans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Modulating the development of E. coli biofilms with 2-aminoimidazoles
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(21), 6310–6312.
author keywords: 2-Aminoimidazoles; E. coli; Biofilms
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Drug Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Hemolysis / drug effects; Humans; Imidazoles / chemical synthesis; Imidazoles / pharmacology; In Vitro Techniques; Structure-Activity Relationship
TL;DR:
The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported, with the best inhibitor inhibiting biofilm development with an IC(50) of 13μM.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(5), 2112–2118.
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Calcium Chloride / pharmacology; Chlorides / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial; Drug Resistance, Multiple; Drug Synergism; Enterococcus faecium / drug effects; Erythrocytes / drug effects; Escherichia coli / drug effects; Humans; Imidazoles / chemistry; Imidazoles / pharmacology; Magnesium / pharmacology; Manganese Compounds / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Novobiocin / pharmacology; Staphylococcus epidermidis / drug effects; Tobramycin / pharmacology; Triazoles / pharmacology
TL;DR:
The synergistic effect between a 2-aminoimidazole/triazole conjugate and antibiotics toward dispersing preestablished biofilms, culminating with a 3-orders-of-magnitude increase of biofilm dispersion toward Staphylococcus aureus biofilmms is reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives
Organic & Biomolecular Chemistry, 8(17), 3857–3859.
Source: NC State University Libraries
Added: August 6, 2018
2010 journal article
Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(4), 1257–1260.
author keywords: Biofilms; Anti-biofilm; Antibiotic; 2-Aminoimidazole; Menthyl carbamate
TL;DR:
The successful marriage of structural features from 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilm modulators.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(29), 9868-+.
MeSH headings : Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Dose-Response Relationship, Drug; Gram-Positive Bacteria / drug effects; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; Zinc / chemistry; Zinc / pharmacology
TL;DR:
Mechanistic studies showed that the activity of a lead 2-aminobenzimidazole is Zn(II)-dependent, potentially via a direct zinc-chelating mechanism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates
ORGANIC & BIOMOLECULAR CHEMISTRY, 7(4), 794–802.
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Biofilms / drug effects; Imidazoles / chemistry; Pseudomonas aeruginosa / drug effects; Small Molecule Libraries / chemical synthesis; Staphylococcus aureus / drug effects; Triazoles / chemical synthesis
TL;DR:
A chemically diverse library of TAGE-triazole conjugates synthesized utilizing click chemistry on the TAGE scaffold demonstrated the most potent inhibitory effect against Staphylococcus aureus biofilm formation that has been displayed by any 2-aminoimidazole derivative.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii
BIOORGANIC & MEDICINAL CHEMISTRY, 18(2), 663–674.
author keywords: 2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Resistance, Multiple, Bacterial; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Conformation; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
TL;DR:
These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
Tandem dispersion and killing of bacteria from a biofilm
ORGANIC & BIOMOLECULAR CHEMISTRY, 7(3), 603–606.
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / growth & development; Biofilms; Microbial Viability / drug effects; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Triazoles / chemistry; Triazoles / pharmacology
TL;DR:
The combined effects of biofilm dispersion with a 2-aminoimidazole-triazole conjugate and bactericidal activity with a photodynamic inactivation agent suggest a novel combination therapy for treating diverse microbial infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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