Stephen Alexander Tuin

Works (4)

Updated: July 5th, 2023 15:42

2020 journal article

Developing Implantable Scaffolds to Enhance Neural Stem Cell Therapy for Post-Operative Glioblastoma

MOLECULAR THERAPY, 28(4), 1056–1067.

By: K. Sheets*, M. Ewend*, M. Mohiti-Asli  n, S. Tuin n, E. Loboa*, K. Aboody *, S. Hingtgen *

MeSH headings : Animals; Brain Neoplasms / pathology; Brain Neoplasms / surgery; Brain Neoplasms / therapy; Cell Line, Tumor; Combined Modality Therapy; Ganciclovir / administration & dosage; Ganciclovir / pharmacology; Glioblastoma / pathology; Glioblastoma / surgery; Glioblastoma / therapy; Humans; Luminescent Measurements; Mice; Neural Stem Cells / metabolism; Neural Stem Cells / transplantation; Polyesters / chemistry; Prodrugs / administration & dosage; Prodrugs / pharmacology; Thymidine Kinase / metabolism; Tissue Scaffolds / chemistry; Treatment Outcome; Xenograft Model Antitumor Assays
TL;DR: Design parameters for effective scaffold/tNSC composites are defined and suggest a new approach to maximizing the efficacy of tNSC therapy in human patient trials. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 27, 2020

2016 journal article

Creating tissues from textiles: scalable nonwoven manufacturing techniques for fabrication of tissue engineering scaffolds

BIOMEDICAL MATERIALS, 11(1).

By: S. Tuin n, B. Pourdeyhimi n  & E. Loboa n

author keywords: human adipose derived stem cells; nonwoven tissue engineering scaffolds; scalable tissue engineering
MeSH headings : Adipogenesis / physiology; Biocompatible Materials / chemical synthesis; Cell Differentiation / physiology; Cell Survival / physiology; Cells, Cultured; Equipment Design; Equipment Failure Analysis; Humans; Lactic Acid / chemistry; Materials Testing; Osteogenesis / physiology; Polyesters; Polymers / chemistry; Stem Cells / cytology; Stem Cells / physiology; Textiles; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds
TL;DR: Nonwovens manufactured via these industry standard, commercially relevant manufacturing techniques were capable of supporting hASC attachment, proliferation, and both adipogenic and osteogenic differentiation of hASC, making them promising candidates for commercialization and translation of nonwoven scaffold based tissue engineering strategies. (via Semantic Scholar)
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9. Industry, Innovation and Infrastructure (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Fabrication of novel high surface area mushroom gilled fibers and their effects on human adipose derived stem cells under pulsatile fluid flow for tissue engineering. applications

ACTA BIOMATERIALIA, 36, 220–230.

By: S. Tuin n, B. Pourdeyhimi n  & E. Loboa n

author keywords: Gilled high surface area fibers; Human adipose derived stem cells; Pulsatile fluid slow; Shear stress; Scalable tissue engineering scaffolds
MeSH headings : Adipose Tissue / cytology; Adipose Tissue / metabolism; Agaricales; Cells, Cultured; Humans; Pulsatile Flow; Stem Cells / cytology; Stem Cells / metabolism; Tissue Engineering / instrumentation; Tissue Engineering / methods; Tissue Scaffolds / chemistry
TL;DR: The successful fabrication of novel high surface area gilled fiber scaffolds for tissue engineering applications is reported for the first time, and in the absence of osteogenic induction factors, gilled fibers led to significantly increased mRNA expression of an early marker for osteogenesis after exposure to pulsatile fluid flow. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 review

Interconnected, microporous hollow fibers for tissue engineering: Commercially relevant, industry standard scale-up manufacturing

[Review of ]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 102(9), 3311–3323.

By: S. Tuin n, B. Pourdeyhimi n  & E. Loboa n

author keywords: spunbond process; hollow porous fibers; industry standard scale-up manufacturing; tissue engineering; stem cells
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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