The role of cellular contact and TGF-beta signaling in the activation of the epithelial mesenchymal transition (EMT)
Gasior, K., Wagner, N. J., Cores, J., Caspar, R., Wilson, A., Bhattacharya, S., & Hauck, M. L. (2018, October 8). Cell Adhesion & Migration, Vol. 13, pp. 63–75.
author keywords: EMT; TGF-; cellular adhesion; epithelial; mesenchymal; breast carcinoma; colon carcinoma
MeSH headings : Adenocarcinoma / metabolism; Adenocarcinoma / pathology; Breast Neoplasms / metabolism; Breast Neoplasms / pathology; Cell Adhesion; Cell Movement; Colorectal Neoplasms / metabolism; Colorectal Neoplasms / pathology; Epithelial-Mesenchymal Transition / drug effects; Female; Humans; Signal Transduction; Transforming Growth Factor beta / pharmacology; Tumor Cells, Cultured
topics (OpenAlex): Cancer Cells and Metastasis; Digestive system and related health
TL;DR:
Examination of the dual influence of the TGF-β pathway and intercellular contact on the activation of EMT in colon (SW480) and breast (MCF7) carcinoma cells highlights that, while EMT is induced by the synergy of multiple signals, this activation varies across cell types.
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