My research interests: • Environmental factors affecting fetal outcomes & latent health effects (DOHaD) • Environmental modifiers of fetal/pubertal mammary gland development (puberty timing) • Health effects related to perfluoroalkyl substances (PFAS) – metabolic disease focus • Effect of environmental factors on a mother’s ability to lactate & transfer to milk/offspring • Chemical effects on breast cancer risk factors such as obesity, breast density, and hormones • Methods and models for assessing mammary development, function, and disease

Works (12)

Updated: April 3rd, 2024 18:08

2023 journal article

Effective coordination, collaboration, communication, and partnering are needed to close the gaps for occupational PFAS exposure

American Journal of Industrial Medicine.

Source: ORCID
Added: October 28, 2023

2023 journal article

Erratum: Current Breast Milk PFAS Levels in the United States and Canada: After All This Time, Why Don’t We Know More?

Environmental Health Perspectives.

By: J. LaKind, M. Verner, R. Rogers, H. Goeden, D. Naiman, S. Marchitti, G. Lehmann, E. Hines, S. Fenton

Source: ORCID
Added: October 28, 2023

2023 review

Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

[Review of ]. CANCERS, 15(9).

By: B. Rickard*, M. Overchuk n, V. Chappell*, M. Kemal Ruhi*, P. Sinawang*, T. Nguyen Hoang*, D. Akin*, U. Demirci ...

author keywords: mitochondrial methods; bioenergetics; mitochondrial dysfunction; reactive species; mitochondrial function; mitochondrial structure; extracellular vesicles
TL;DR: Methods to evaluate the structural and functional parameters of mitochondrial health in the context of tumors and cancer cells are discussed, with a particular emphasis on gynecologic malignancies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: ORCID, Web Of Science
Added: May 30, 2023

2023 journal article

Per- and Polyfluoroalkyl Substances and Breastfeeding as a Vulnerable Function: A Systematic Review of Epidemiological Studies

Toxics.

TL;DR: The finding of a potential causal association between PFAS exposure and breastfeeding duration is in agreement with findings from experimental studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 28, 2023

2023 journal article

Per- and polyfluoroalkyl substances (PFAS) in breast milk and infant formula: A global issue

Environmental Research.

By: J. LaKind*, J. Naiman*, M. Verner*, L. Lévêque* & S. Fenton*

TL;DR: A comparison of global breast milk and infant formula PFAS measurements with the only reported health-based drinking water screening values specific to children is presented, suggesting limited information on infant formula suggests its use does not necessarily result in lower PFAS exposures. (via Semantic Scholar)
Source: ORCID
Added: October 28, 2023

2022 journal article

Chemical Effects on Breast Development, Function, and Cancer Risk: Existing Knowledge and New Opportunities

Current Environmental Health Reports.

TL;DR: Increasing the rigor of MG assessment would improve the ability to identify chemicals of concern, regulate those chemicals based on their effects, and prevent exposures and associated adverse health effects. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: October 28, 2023

2022 journal article

Current Breast Milk PFAS Levels in the United States and Canada: After All This Time, Why Don’t We Know More?

Environmental Health Perspectives.

TL;DR: Exceeding a children’s drinking water screening value does not indicate that adverse health effects will occur and should not be interpreted as a reason to not breastfeed; it indicates that the situation should be further evaluated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: October 28, 2023

2022 journal article

Per- and poly-fluoroalkyl substances (PFAS) and female reproductive outcomes: PFAS elimination, endocrine-mediated effects, and disease

TOXICOLOGY, 465.

author keywords: PFAS; Female reproduction; Environmental contaminants; Endocrine disruption
MeSH headings : Endocrine Disruptors / adverse effects; Endocrine System Diseases / chemically induced; Endocrine System Diseases / metabolism; Endocrine System Diseases / physiopathology; Environmental Exposure / adverse effects; Environmental Pollutants / adverse effects; Female; Fertility / drug effects; Humans; Hydrocarbons, Fluorinated / adverse effects; Infertility, Female / chemically induced; Infertility, Female / metabolism; Infertility, Female / physiopathology; Menstrual Cycle / drug effects; Pregnancy; Pregnancy Complications / chemically induced; Pregnancy Complications / metabolism; Pregnancy Complications / physiopathology; Prognosis; Reproduction / drug effects; Risk Assessment; Risk Factors
TL;DR: The role of a variety of PFAS and PFAS mixtures in female reproductive tract dysfunction and disease is summarized and the role ofPFAS in breast, thyroid, and hypothalamic-pituitary-gonadal axis function is discussed as the interplay between these tissues may be critical in understanding the long-term reproductive health effects of PFas in women. (via Semantic Scholar)
Sources: ORCID, Web Of Science
Added: November 29, 2021

2022 journal article

Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(9).

author keywords: per- and polyfluoroalkyl substances; PFAS; ovarian cancer; platinum resistance; carboplatin; mitochondrial function
MeSH headings : Alkanesulfonic Acids / toxicity; Carboplatin / pharmacology; Carcinoma, Ovarian Epithelial; Cell Line; Environmental Pollutants / toxicity; Female; Fluorocarbons / toxicity; Humans; Ovarian Neoplasms / drug therapy
TL;DR: This is the first study to demonstrate that, at sub-cytotoxic concentrations, select PFAS and PFAS mixtures increased survival fraction in ovarian cancer cells following carboplatin treatment, indicative of platinum resistance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: ORCID, Web Of Science
Added: May 23, 2022

2021 journal article

Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation

Emerging Contaminants, 7, 219–235.

TL;DR: Prenatal exposure to 1mg/kg GenX and 1 mg/kg PFOA induces adverse metabolic outcomes in adult mice that are diet- and sex-dependent, suggesting that placental and potentially lactational transfer are important exposure routes for GenX. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: October 28, 2023

2021 journal article

Looking for Proof in the Wrong Generation?

Cancer Epidemiology, Biomarkers & Prevention, 30(8), 1459–1461.

By: S. Fenton* & A. Boyles*

TL;DR: The article in this issue “Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort,” by Cirillo and colleagues, is the first to report multigenerational health effects in granddaughters stemming from early life exposures to the pesticide o,p'-DDT in grandmothers. (via Semantic Scholar)
Source: ORCID
Added: October 28, 2023

2019 journal article

Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats

NEUROTOXICOLOGY, 75, 136–147.

author keywords: brain; anxiety; endocrine disruptions; sex differences; hyperactivity; neural; sexually dimorphic; neurotoxic; flame retardants; elevated plus maze; neurodevelopment
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Maze Learning / drug effects; Motor Activity / drug effects; Polybrominated Biphenyls / toxicity; Rats; Rats, Wistar / growth & development; Sex Factors
TL;DR: It is demonstrated that exposure to environmental contaminants, like TBBPA, can have sex-specific effects on behavior highlighting the vulnerability of the developing brain. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 16, 2019

Employment

Updated: October 22nd, 2023 21:52

2023 - present

North Carolina State University Raleigh, North Carolina, US
Director, Center for Human Health and the Environment Biological Sciences

2009 - 2023

National Institute of Environmental Health Sciences Durham, North Carolina, US
Group Lead Mechanistic Toxicology Branch

1998 - 2009

U.S. Environmental Protection Agency Durham, North Carolina, US
Research Biologist NHEERL

Education

Updated: January 26th, 2023 23:04

University of Wisconsin–Madison Madison, WI, US
PhD Endocrinology-Reproductive Physiology Program

University of Wisconsin–Madison Madison, WI, US
M.S. Endocrinology-Reproductive Physiology Program

University of Wisconsin–Madison Madison, WI, US
B.S. Natural Science Dairy Science

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