The anti-inflammatory effect of topical tofacitinib on immediate and late-phase cutaneous allergic reactions in dogs: a placebo-controlled pilot study
VETERINARY DERMATOLOGY, 29(3), 250-+.
MeSH headings : Animals; Anti-Inflammatory Agents / therapeutic use; Dermatitis, Atopic / drug therapy; Dermatitis, Atopic / veterinary; Dog Diseases / drug therapy; Dogs; Hypersensitivity, Delayed / drug therapy; Hypersensitivity, Delayed / veterinary; Hypersensitivity, Immediate / drug therapy; Hypersensitivity, Immediate / veterinary; Inflammation / drug therapy; Inflammation / veterinary; Pilot Projects; Piperidines / pharmacology; Pyrimidines / pharmacology; Pyrroles / pharmacology
TL;DR:
It is suggested that topical tofacitinib exerts an inhibitory effect on activated canine skin-emigrating immune cells; this drug should be investigated further as a topical immunosuppressive drug in dogs.
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