Sarah Elizabeth Kubik

College of Engineering

Works (3)

Updated: July 21st, 2025 14:37

2025 article

Microphysiological Uremia Model Reveals Biophysical Potentiators of Vascular Dysfunction

Rathod, M., Stack, R. N., Kubik, S. E., Huang, S. A., Whitworth, C. P., Aw, W. Y., … Polacheck, W. J. (2025, June 20). Advanced Science.

By: M. Rathod n, R. Stack n, S. Kubik n, S. Huang n, C. Whitworth *, W. Aw n, E. Doherty  n, S. Meehan n, P. Roy‐Chaudhury *, W. Polacheck n

author keywords: cardiovascular disease; chronic kidney disease; mechanobiology; microfluidics; organ-on-chip; uremic toxin; vascular endothelium
topics (OpenAlex): Dialysis and Renal Disease Management; Blood properties and coagulation; Erythropoietin and Anemia Treatment
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3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: June 30, 2025

2024 article

A nanoporous hydrogel-based model to study chemokine gradient-driven angiogenesis under luminal flow

Mote, N., Kubik, S., Polacheck, W. J., Baker, B. M., & Trappmann, B. (2024, January 1). Lab on a Chip.

By: N. Mote*, S. Kubik n, W. Polacheck n, B. Baker * & B. Trappmann *

MeSH headings : Humans; Neovascularization, Physiologic / drug effects; Hydrogels / chemistry; Human Umbilical Vein Endothelial Cells / metabolism; Chemokines / metabolism; Nanopores; Models, Biological; Angiogenesis
topics (OpenAlex): Angiogenesis and VEGF in Cancer; Cell Adhesion Molecules Research; Photoacoustic and Ultrasonic Imaging
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Source: Web Of Science
Added: September 30, 2024

2023 article

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

Aw, W. Y., Cho, C., Wang, H., Cooper, A. H., Doherty, E. L., Rocco, D., … Polacheck, W. J. (2023, February 15). Science Advances.

By: W. Aw  n, C. Cho  n, H. Wang  n, A. Cooper n, E. Doherty  n, D. Rocco *, S. Huang n, S. Kubik n ...

MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
topics (OpenAlex): Vascular Malformations and Hemangiomas; Vascular Malformations Diagnosis and Treatment; Vascular Tumors and Angiosarcomas
TL;DR: These findings demonstrate an in vitro platform for VMs and establish a role of dysregulated Rac1/PAK and mTORC1/2 signaling in PIK3CA-driven VMs. (via Semantic Scholar)
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Source: Web Of Science
Added: March 27, 2023

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