Sarah Elizabeth Kubik

College of Engineering

Works (2)

Updated: October 2nd, 2024 05:03

2024 article

A nanoporous hydrogel-based model to study chemokine gradient-driven angiogenesis under luminal flow

Mote, N., Kubik, S., Polacheck, W. J., Baker, B. M., & Trappmann, B. (2024, September 11). LAB ON A CHIP.

By: N. Mote *, S. Kubik n, W. Polacheck n, B. Baker * & B. Trappmann *

Source: Web Of Science
Added: September 30, 2024

2023 journal article

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation

SCIENCE ADVANCES, 9(7).

By: W. Aw  n, C. Cho  n, H. Wang  n, A. Cooper n, E. Doherty  n, D. Rocco *, S. Huang n, S. Kubik n ...

MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
TL;DR: These findings demonstrate an in vitro platform for VMs and establish a role of dysregulated Rac1/PAK and mTORC1/2 signaling in PIK3CA-driven VMs. (via Semantic Scholar)
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Source: Web Of Science
Added: March 27, 2023

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