Steven E Suter

Works (59)

Updated: June 3rd, 2024 08:14

2024 article

Postmortem pathologic findings in dogs that underwent total body irradiation and hematopoietic cell transplant: A case series of five dogs with B-cell multicentric lymphoma

Benedict, W., Suter, S., & Meritet, D. (2024, May 2). VETERINARY PATHOLOGY.

By: W. Benedict n, S. Suter n & D. Meritet n

author keywords: canine; hematopoietic cell transplant; lymphoma; oncology; pathology; total body irradiation
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 28, 2024

2022 article

Allogeneic peripheral blood haematopoietic stem cell transplantation for the treatment of dogs with high-grade B-cell lymphoma

Gareau, A., Sekiguchi, T., Warry, E., Ripoll, A. Z., Sullivan, E., Westfall, T., … Suter, S. E. (2022, July 26). VETERINARY AND COMPARATIVE ONCOLOGY.

By: A. Gareau n, T. Sekiguchi n, E. Warry n, A. Ripoll n, E. Sullivan*, T. Westfall *, J. Chretin*, L. Fulton ...

author keywords: comparative oncology; hematology; oncology; small animal; stem cells
MeSH headings : Dogs; Animals; Humans; Transplantation, Homologous / veterinary; Retrospective Studies; Dog Diseases / surgery; Neoplasm Recurrence, Local / veterinary; Hematopoietic Stem Cell Transplantation / veterinary; Hematopoietic Stem Cell Transplantation / methods; Lymphoma, B-Cell / surgery; Lymphoma, B-Cell / veterinary
TL;DR: It is suggested that allogeneic HCT can cure ~50% more dogs than those treated with autologous HCT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 1, 2022

2022 article

Centrifugal therapeutic plasma exchange in dogs with immune-mediated hemolytic anemia (2016-2018): 7 cases

Culler, C. A., Vigani, A., Ripoll, A. Z., Gareau, A., & Suter, S. E. (2022, May 2). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE.

By: C. Culler n, A. Vigani n, A. Ripoll n, A. Gareau n & S. Suter n

author keywords: canine; IMHA; therapeutic plasma exchange
MeSH headings : Anemia, Hemolytic, Autoimmune / therapy; Anemia, Hemolytic, Autoimmune / veterinary; Animals; Anticoagulants / therapeutic use; Bilirubin; Citrates; Dog Diseases; Dogs; Humans; Immunosuppressive Agents / therapeutic use; Plasma Exchange / veterinary
TL;DR: Retrospective review of cTPE performed at North Carolina State University from 2016 to 2018, through a search of the institutional database for cTPe and IMHA, shows it is a feasible and relatively safe bridging treatment option for the management of canine IMHA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: May 16, 2022

2022 journal article

Doxorubicin for treatment of histiocytic sarcoma in dogs: 31 cases (2003-2017)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 260(14), 1827–1833.

By: R. Doka n, S. Suter n, M. Mastromauro n, A. Bennett  n & P. Hess n 

MeSH headings : Dogs; Animals; Histiocytic Sarcoma / veterinary; Retrospective Studies; Dog Diseases / diagnosis; Doxorubicin / therapeutic use; Treatment Outcome
TL;DR: Benefits of doxorubicin administration in canine HS are modest, with a limited ORR and delay in tumor progression, and are comparable to effects attained with other single-agent regimens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

Outcomes of 434 dogs with non-steroidal anti-inflammatory drug toxicosis treated with fluid therapy, lipid emulsion, or therapeutic plasma exchange

Chalifoux, N. V., Butty, E. M., Mauro, K. D., Moyle, R. B., Ehrhardt, C. M., Robertson, J. B., … Lynch, A. M. (2022, December 1). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 12.

By: N. Chalifoux *, E. Butty *, K. Mauro *, R. Moyle, C. Ehrhardt *, J. Robertson n , M. Labato *, C. Culler ...

Contributors: J. Robertson n 

author keywords: carprofen; ibuprofen; ILE; intoxication; naproxen; NSAID; TPE
MeSH headings : Dogs; Animals; Ibuprofen / adverse effects; Plasma Exchange / veterinary; Retrospective Studies; Creatinine; Emulsions / adverse effects; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Fluid Therapy / veterinary; Dog Diseases / chemically induced; Dog Diseases / therapy; Dog Diseases / diagnosis; Lipids
TL;DR: Despite similar outcomes of lower incidence of AKI in the TPE group, and slightly lower maximal creatinine concentration in dogs treated with ILE vs IVF alone, ILE and TPE should be considered in the management of severe NSAID toxicosis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 7, 2022

2022 article

Outcomes of nonsteroidal anti-inflammatory drug toxicosis treated with therapeutic plasma exchange in 62 dogs

Butty, E. M., Suter, S. E., Chalifoux, N. V., Lynch, A. M., Mauro, K. D., Moyle, R. B., … Labato, M. A. (2022, August 5). JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 8.

By: E. Butty *, S. Suter n, N. Chalifoux *, A. Lynch n , K. Mauro *, R. Moyle, C. Ehrhardt *, J. Robertson n  ...

author keywords: carprofen; ibuprofen; naproxen; NSAID; TPE
MeSH headings : Animals; Anti-Inflammatory Agents, Non-Steroidal / adverse effects; Dog Diseases / drug therapy; Dog Diseases / therapy; Dogs; Drug Overdose / therapy; Drug Overdose / veterinary; Ibuprofen / adverse effects; Naproxen / therapeutic use; Plasma Exchange / veterinary; Retrospective Studies
TL;DR: This population of dogs managed with TPE had excellent outcomes, even in cases of high NSAID dose ingestion, when TPE is available and the time frame is appropriate, this extracorporeal modality should be considered for the management of NSAID overdose. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 15, 2022

2021 journal article

A Retrospective Analysis: Autologous Peripheral Blood Hematopoietic Stem Cell Transplant Combined With Adoptive T-Cell Therapy for the Treatment of High-Grade B-Cell Lymphoma in Ten Dogs

FRONTIERS IN VETERINARY SCIENCE, 8.

By: A. Gareau n, A. Ripoll n & S. Suter n

author keywords: adoptive T-Cell therapy; dogs; lymphoma; hematopoietic stem cell transplantation; CHOP chemotherapy
TL;DR: The results can only suggest that the administration of ACT to dogs after multiagent chemotherapy and autoPHSCT did not lead to a statistically significant increase in median disease-free interval and overall survival when compared to dogs who received CHOP chemotherapy and autologous peripheral blood T-cells alone. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 18, 2022

2021 journal article

Adjuvant Sirolimus Does Not Improve Outcome in Pet Dogs Receiving Standard-of-Care Therapy for Appendicular Osteosarcoma: A Prospective, Randomized Trial of 324 Dogs

CLINICAL CANCER RESEARCH, 27(11), 3005–3016.

By: A. LeBlanc *, C. Mazcko *, A. Cherukuri*, E. Berger *, W. Kisseberth *, M. Brown *, S. Lana*, K. Weishaar * ...

MeSH headings : Amputation, Surgical; Animals; Bone Neoplasms / genetics; Bone Neoplasms / mortality; Bone Neoplasms / therapy; Bone Neoplasms / veterinary; Carboplatin / administration & dosage; Chemotherapy, Adjuvant; Combined Modality Therapy / veterinary; Dog Diseases / mortality; Dog Diseases / therapy; Dogs; Osteosarcoma / genetics; Osteosarcoma / mortality; Osteosarcoma / therapy; Osteosarcoma / veterinary; Pets; Prospective Studies; Signal Transduction / drug effects; Sirolimus / administration & dosage; Sirolimus / pharmacology; Survival Rate; TOR Serine-Threonine Kinases / metabolism; Treatment Outcome
TL;DR: In a population of pet dogs nongenomically segmented for predicted mTOR inhibition response, sequentially administered adjuvant sirolimus, although well tolerated when added to a backbone of therapy, did not extend DFI or survival in dogs with appendicular osteosarcoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 21, 2021

2019 journal article

Clinical Application of Apheresis in Very Small Dogs Weighing < 8 kg to Pediatric Patients

Clinical Application of Apheresis in Very Small Dogs Weighing < 8 kg to Pediatric Patients. THERAPEUTIC APHERESIS AND DIALYSIS, 24(3), 333–342.

By: T. Sekiguchi n, A. Vigani n, A. Ripoll n, S. Taylor  n, C. Culler n & S. Suter n

author keywords: Canine; Hematopoietic stem cell transplantation; Leukapheresis; Plasma exchange; Total blood volume
MeSH headings : Animals; Blood Component Removal / adverse effects; Blood Component Removal / methods; Blood Volume Determination / methods; Body Size / physiology; Body Weight / physiology; Dogs; Hematopoietic Stem Cell Transplantation / methods; Hypotension / etiology; Hypotension / physiopathology; Hypotension / prevention & control; Leukapheresis / instrumentation; Leukapheresis / methods; Models, Animal; Plasma Exchange / methods; Thinness / diagnosis; Thinness / physiopathology; Treatment Outcome
TL;DR: It is concluded that aphereses in very small dogs is feasible if close attention is paid to hemodynamic stability and citrate toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 28, 2019

2019 journal article

Implementation of total body photon irradiation as part of an institutional bone marrow transplant program for the treatment of canine lymphoma and leukemias

VETERINARY RADIOLOGY & ULTRASOUND, 60(5), 586–593.

By: T. Gieger n , M. Nolan n, D. Roback n & S. Suter n

author keywords: cadaver; lymphosarcoma; myeloablation; thermoluminescent dosimeter
MeSH headings : Animals; Bone Marrow Transplantation / methods; Bone Marrow Transplantation / veterinary; Dog Diseases / radiotherapy; Dogs; Female; Leukemia / radiotherapy; Leukemia / veterinary; Lymphoma / radiotherapy; Lymphoma / veterinary; Male; Photons; Prospective Studies; Radiotherapy Dosage / veterinary; Whole-Body Irradiation / methods; Whole-Body Irradiation / veterinary
TL;DR: A total body irradiation (TBI) protocol was developed to support a bone marrow transplant (BMT) program for the treatment of canine hematologic malignancies and resultant dosimetry was described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: October 7, 2019

2019 journal article

Incidence and risk factors associated with development of clinical cardiotoxicity in dogs receiving doxorubicin

Journal of Veterinary Internal Medicine, 33(2), 783–791.

By: B. Hallman n, M. Hauck n, L. Williams*, P. Hess n  & S. Suter n

author keywords: canine; cardiology; cardiomyopathy; chemotherapy; echocardiography; oncology
MeSH headings : Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / adverse effects; Antibiotics, Antineoplastic / therapeutic use; Body Weight; Cardiomyopathy, Dilated / veterinary; Cardiotoxicity / veterinary; Dog Diseases / drug therapy; Dogs; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Doxorubicin / therapeutic use; Female; Heart Diseases / chemically induced; Heart Diseases / veterinary; Incidence; Male; Neoplasms / drug therapy; Neoplasms / veterinary; Retrospective Studies; Risk Factors
TL;DR: Overall, the incidence of clinical DOX‐induced cardiotoxicity is low, but Boxers and other breeds at high risk for dilated cardiomyopathy may be at an increased risk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: April 22, 2019

2018 journal article

Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy

NANO LETTERS, 18(12), 7784–7793.

By: P. Yousefpour *, J. McDaniel *, V. Prasad*, L. Ahn *, X. Li *, R. Subrahmanyan*, I. Weitzhandler *, S. Suter n, A. Chilkoti *

author keywords: Micelles; endogenous albumin; elastin like polypeptide; cancer; drug delivery; canine model
MeSH headings : Albumins / metabolism; Animals; Antibiotics, Antineoplastic / administration & dosage; Antibiotics, Antineoplastic / pharmacokinetics; Binding Sites; Cell Line, Tumor; Dogs; Doxorubicin / administration & dosage; Doxorubicin / pharmacokinetics; Drug Carriers / chemistry; Drug Carriers / metabolism; Humans; Mice; Micelles; Nanoparticles / chemistry; Nanoparticles / metabolism; Neoplasms / drug therapy; Neoplasms / metabolism; Peptides / chemistry; Peptides / metabolism; Protein Binding; Protein Domains; Recombinant Fusion Proteins / chemistry; Recombinant Fusion Proteins / metabolism
TL;DR: In a murine and canine model, albumin-binding nanoparticles demonstrated lower uptake by the reticuloendothelial system (RES) system organs, the liver and spleen, that are the main target organs of toxicity for nanoparticulate delivery systems and higher uptake byThe tumor than naked micelles. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: January 7, 2019

2018 journal article

The canine MHC class Ia allele DLA-88*508:01 presents diverse self- and canine distemper virus-origin peptides of varying length that have a conserved binding motif

Veterinary Immunology and Immunopathology, 197, 76–86.

By: P. Ross n, P. Nemec n, A. Kapatos n, K. Miller*, J. Holmes n, S. Suter n, A. Buntzman *, E. Soderblom * ...

author keywords: Canine distemper virus; CD8(+) T lymphocytes; MHC; Peptides/Epitopes; Retrovirus
MeSH headings : Alleles; Amino Acid Motifs; Animals; Antigen Presentation; Distemper Virus, Canine / chemistry; Distemper Virus, Canine / immunology; Dogs / genetics; Epitopes / chemistry; Epitopes / immunology; Genes, MHC Class I; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Peptides / chemistry; Peptides / immunology; Protein Binding; T-Lymphocytes / immunology; Viral Proteins / chemistry; Viral Proteins / immunology
TL;DR: The presentation of diverse self and viral peptides indicates that DLA-88 is a classical MHC class Ia gene, and thus, potential targets of anti-viral CTL in D LA-88*508:01-bearing dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019

2017 journal article

Oral melphalan for the treatment of relapsed canine lymphoma

Veterinary and Comparative Oncology, 16(1), E123–E129.

By: M. Mastromauro n, S. Suter n, M. Hauck n & P. Hess n 

author keywords: canine; chemotherapy; lymphoma; melphalan; rescue
MeSH headings : Administration, Oral; Animals; Antineoplastic Agents, Alkylating / administration & dosage; Antineoplastic Agents, Alkylating / adverse effects; Antineoplastic Agents, Alkylating / therapeutic use; Dog Diseases / drug therapy; Dogs; Female; Lymphoma / drug therapy; Lymphoma / veterinary; Male; Melphalan / administration & dosage; Melphalan / adverse effects; Melphalan / therapeutic use; Recurrence; Retrospective Studies
TL;DR: Although treatment resulted in limited clinical benefit and non-durable responses, oral melphalan was well-tolerated and may be a reasonable rescue option in cases where minimal effective agents remain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

A Comparative Oncology Study of Iniparib Defines Its Pharmacokinetic Profile and Biological Activity in a Naturally-Occurring Canine Cancer Model

PLOS ONE, 11(2).

By: C. Saba *, M. Paoloni*, C. Mazcko *, W. Kisseberth *, J. Burton *, A. Smith *, H. Wilson-Robles *, S. Allstadt * ...

MeSH headings : Animals; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / therapeutic use; Benzamides / pharmacokinetics; Benzamides / therapeutic use; Breast Neoplasms / drug therapy; Dogs; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Male; Maximum Tolerated Dose; Neoplasms / drug therapy; Neoplasms / veterinary; Poly(ADP-ribose) Polymerase Inhibitors / pharmacokinetics; Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use; Triple Negative Breast Neoplasms / drug therapy
TL;DR: In this study, iniparib was well tolerated as a single agent and in combination with carboplatin over a range of doses and clinically relevant concentrations of the parent drug and selected metabolites were not detectable in canine tumor tissues at any studied dose, thus eliminating expectations for clinical responses in dogs or humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Canine acute leukaemia: 50 cases (1989-2014)

Veterinary and Comparative Oncology, 15(3), 1101–1114.

By: A. Bennett  n, L. Williams n, M. Ferguson  n, M. Hauck n, S. Suter n, C. Lanier n, P. Hess n 

author keywords: acute leukaemia; canine; chemotherapy; CHOP; immunophenotype
MeSH headings : Acute Disease; Animals; Antineoplastic Agents / adverse effects; Antineoplastic Agents / therapeutic use; Dog Diseases / drug therapy; Dog Diseases / mortality; Dogs; Leukemia / drug therapy; Leukemia / mortality; Leukemia / veterinary; Retrospective Studies; Survival Analysis; Treatment Outcome
TL;DR: Most dogs developed chemoresistance within weeks of initiating treatment, and consequently, survival times for AL remain disappointingly short. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

BMC Veterinary Research, 12.

By: S. Roode, D. Rotroff, K. Richards, P. Moore, A. Motsinger-Reif, Y. Okamura, T. Mizuno, H. Tsujimoto, S. Suter, M. Breen 

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Expression of Apoptosis-regulating Proteins Bcl-2 and Bax in Lymph Node Aspirates from Dogs with Lymphoma

JOURNAL OF VETERINARY INTERNAL MEDICINE, 30(3), 819–826.

By: K. Meichner n, J. Fogle n, L. English n & S. Suter n

author keywords: Canine; Flow cytometry; Lymphosarcoma; Programmed cell death
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / therapeutic use; Apoptosis; Case-Control Studies; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation, Neoplastic; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / drug therapy; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / drug therapy; Lymphoma, T-Cell / pathology; Lymphoma, T-Cell / veterinary; Male; Prospective Studies; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / metabolism; Systole; Treatment Outcome; bcl-2-Associated X Protein / genetics; bcl-2-Associated X Protein / metabolism
TL;DR: Whether Bcl‐2/Bax will be helpful to identify canine BCL and TCL with more aggressive and more indolent behavior, respectively, should be evaluated in larger prospective clinical studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Surgical Management of Colonic Adenocarcinoma in a Rat (Rattus norvegicus)

Journal of Exotic Pet Medicine, 26(1), 47–52.

By: J. Applegate*, B. Troan  n, L. Chen n & S. Suter n

author keywords: rat; Rattus norvegicus; adenocarcinoma; subtotal colectomy; cancer
TL;DR: The rat lived for 2 years, following colonic resection and anastomosis, uncomplicated by gastrointestinal neoplasia or metastatic disease and was euthanized due to unrelated quality of life issues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science
Added: August 6, 2018

2015 journal article

Allogeneic hematopoietic cell transplantation in a dog with acute large granular lymphocytic leukemia

Journal of the American Veterinary Medical Association, 246(9), 994–997.

By: S. Suter n, M. Hamilton, E. Sullivan & G. Venkataraman

MeSH headings : Animals; Dog Diseases / therapy; Dogs; Hematopoietic Stem Cell Transplantation / veterinary; Leukemia, Large Granular Lymphocytic / therapy; Leukemia, Large Granular Lymphocytic / veterinary; Male
TL;DR: If an appropriate donor can be located, allogeneic hematopoietic cell transplantation may offer a feasible treatment, although peripheral blood CD34+ cell harvesting requires the availability of cell separator machines and management of graft-versus-host disease with immunosuppressive agents. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

CD45+ and CD45− lymphocyte populations identified by flow cytometry from dogs with lymphoma exhibit similar morphology and the same clonal (B cell or T cell) lineage

Veterinary Immunology and Immunopathology, 168(3-4), 242–248.

By: J. Fogle n, J. Tarigo*, L. Thalheim*, L. Williams*, L. English n & S. Suter n

author keywords: Lymphoma; PARR; Cytology; CD45; Flow cytometry
MeSH headings : Animals; B-Lymphocytes / metabolism; Dog Diseases / immunology; Dog Diseases / metabolism; Dogs; Female; Flow Cytometry / veterinary; Gene Expression Regulation, Neoplastic / physiology; Leukocyte Common Antigens / genetics; Leukocyte Common Antigens / metabolism; Lymphoma / metabolism; Lymphoma / veterinary; Male; T-Lymphocytes / metabolism
TL;DR: Comparing morphology and assess clonal origin between CD45+ and CD45- lymphocyte populations identified by flow cytometry in confirmed cases of canine B- and T-cell lymphoma suggests that theCD45- population identified in dogs with lymphoma represents a phenotypic variant of the CD 45+ population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2015 journal article

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

Chromosome Research, 23(4), 681–708.

By: S. Roode n, D. Rotroff n, A. Avery *, S. Suter n, D. Bienzle *, J. Schiffman *, A. Motsinger-Reif n, M. Breen n 

Contributors: S. Roode n, D. Rotroff n, A. Avery *, S. Suter n, D. Bienzle *, J. Schiffman *, A. Motsinger-Reif n, M. Breen n 

author keywords: Leukemia; Canine; Chromosome; Comparative genomic hybridization; Comparative genomics
MeSH headings : Algorithms; Animals; Cell Transformation, Neoplastic / genetics; Chromosome Aberrations; Chromosome Mapping; Cluster Analysis; Comparative Genomic Hybridization; Conserved Sequence; DNA Copy Number Variations; Disease Models, Animal; Dogs; Evolution, Molecular; Female; Gene Dosage; Genome-Wide Association Study; Genomic Library; Genomics; Humans; In Situ Hybridization, Fluorescence; Leukemia / diagnosis; Leukemia / genetics; Leukemia / metabolism; Male
TL;DR: The use of canine leukemia as a relevant in vivo model for human leukemia is supported and the need to further explore the conserved genomic regions of interest for their clinical impact is justified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2015 personal communication

Questions diagnosis of acute large granular lymphocytic leukemia response

By: S. Suter

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Autologous Peripheral Blood Hematopoietic Cell Transplantation in Dogs with T-Cell Lymphoma

Journal of Veterinary Internal Medicine, 28(2), 529–537.

By: E. Warry n, J. Willcox  n & S. Suter n

MeSH headings : Animals; Blood Component Removal / veterinary; Dog Diseases / surgery; Dogs; Female; Hematopoietic Stem Cell Transplantation / methods; Hematopoietic Stem Cell Transplantation / veterinary; Lymphoma, T-Cell / surgery; Lymphoma, T-Cell / veterinary; Male; Transplantation, Autologous / methods; Transplantation, Autologous / veterinary; Treatment Outcome; Whole-Body Irradiation / veterinary
TL;DR: Peripheral blood hematopoietic cell transplantation (PBHCT) is a feasible treatment option for dogs with B‐cell lymphoma and may be considered as a treatment option in dogs diagnosed with high‐grade TCL. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, Crossref
Added: August 6, 2018

2014 journal article

Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation

AMERICAN JOURNAL OF VETERINARY RESEARCH, 75(5), 425–432.

By: M. Bucknoff n, R. Hanel n, S. Marks n, A. Motsinger-Reif n & S. Suter n

MeSH headings : Animals; Bone Marrow Transplantation / veterinary; Cohort Studies; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Hemorrhage / diagnosis; Hemorrhage / physiopathology; Hemorrhage / veterinary; Hemostasis / physiology; Kaolin; Lymphoma / physiopathology; Lymphoma / veterinary; Male; Platelet Count / veterinary; Prospective Studies; Thrombelastography / methods; Thrombelastography / veterinary; Thrombocytopenia / physiopathology; Thrombocytopenia / veterinary; Whole-Body Irradiation / veterinary
TL;DR: Compared with buccal mucosal bleeding time and platelet count, thromboelastography was more reliable at identifying thrombocytopenic dogs with a low risk of bleeding and could be considered to help guide the use of transfusion products in dogs undergoing TBI and BMT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Man's best friend: what can pet dogs teach us about non-Hodgkin's lymphoma?

Immunological Reviews, 263(1), 173–191.

By: K. Richards  n & S. Suter n

author keywords: cancer; lymph nodes; comparative oncology; signal transduction; molecular biology; knockout mice
MeSH headings : Animals; Breeding; Chromosome Aberrations; Disease Models, Animal; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dogs; Gene-Environment Interaction; Humans; Lymphoma, Non-Hodgkin / diagnosis; Lymphoma, Non-Hodgkin / drug therapy; Lymphoma, Non-Hodgkin / veterinary; Mice; Molecular Targeted Therapy; Treatment Outcome
TL;DR: Resources that are currently available to study canine lymphoma, advantages to be gained by exploiting the genetic breed structure in dogs, and current and future challenges and opportunities to take full advantage of this resource for lymphoma studies are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Apheresis in three dogs weighing <14 kg

Veterinary Anaesthesia and Analgesia, 40(4), 403–409.

By: L. Posner n, J. Willcox  n & S. Suter n

author keywords: apheresis; dog; fluid therapy; chemical restraint
MeSH headings : Anesthetics / pharmacology; Animals; Blood Component Removal / instrumentation; Blood Component Removal / methods; Blood Component Removal / veterinary; Body Weight; Dexmedetomidine / pharmacology; Dogs; Hypnotics and Sedatives / pharmacology; Lymphoma / therapy; Lymphoma / veterinary; Male; Propofol / pharmacology
TL;DR: Dogs as small as 9.9 kg can successfully undergo apheresis with a variety of priming solutions, and Dexmedetomidine or propofol given as a CRI provides sufficient sedation for this procedure. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Evaluation of a side population of canine lymphoma cells using Hoechst 33342 dye

JOURNAL OF VETERINARY SCIENCE, 14(4), 481–486.

By: M. Kim *, S. D'Costa n, S. Suter n & Y. Kim *

author keywords: dog; flow cytometry; Hoechst 33342; lymphoma; side population
MeSH headings : Animals; Benzimidazoles / metabolism; Cell Line, Tumor; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Flow Cytometry / methods; Flow Cytometry / veterinary; Fluorescent Dyes / metabolism; Gene Expression Regulation, Developmental; Lymphoma / diagnosis; Lymphoma / drug therapy; Lymphoma / pathology; Lymphoma / veterinary; Neoplastic Stem Cells / drug effects; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Side-Population Cells / drug effects; Side-Population Cells / metabolism; Side-Population Cells / pathology
TL;DR: The present study was performed to explore the potential value of a side population (SP) assay for identifying and characterizing putative CSCs among canine lymphoma cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Expression of asparagine synthetase predictsin vitroresponse tol-asparaginase in canine lymphoid cell lines

Leukemia & Lymphoma, 55(6), 1357–1365.

By: T. Smallwood*, G. Small *, S. Suter n & K. Richards *

MeSH headings : Animals; Asparaginase / administration & dosage; Asparaginase / pharmacology; Aspartate-Ammonia Ligase / genetics; Aspartate-Ammonia Ligase / metabolism; Azacitidine / pharmacology; Cell Line, Tumor; DNA Methylation; Disease Models, Animal; Dogs; Drug Resistance, Neoplasm; Gene Expression; Humans; Lymphocytes / drug effects; Lymphocytes / metabolism; Lymphoma / drug therapy; Lymphoma / genetics; Lymphoma / metabolism; Lymphoma / mortality; Promoter Regions, Genetic; RNA, Messenger / genetics; RNA, Messenger / metabolism
TL;DR: Using canine lymphoid cell lines, it is found that L-asp sensitivity is strongly negatively correlated with the level of methylation of the asparagine synthetase (ASNS) promoter, and ASNS methylation and expression is not predictive of overall survival or progression-free survival in canine lymphoma patients treated with l-asp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, Crossref
Added: August 6, 2018

2013 journal article

Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL

Cancer Research, 73(16), 5029–5039.

By: K. Richards  n, A. Motsinger-Reif n, H. Chen  n, Y. Fedoriw  n, C. Fan  n, D. Nielsen n , G. Small  n, R. Thomas  n ...

Contributors: K. Richards  n, A. Motsinger-Reif n, H. Chen  n, Y. Fedoriw  n, C. Fan  n, D. Nielsen n , G. Small  n, R. Thomas  n ...

MeSH headings : Adolescent; Animals; Child; Child, Preschool; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Disease Models, Animal; Dogs; Female; Gene Expression Profiling / methods; Germinal Center / metabolism; Germinal Center / pathology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Heavy Chains / metabolism; Interferon Regulatory Factors / genetics; Interferon Regulatory Factors / metabolism; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / pathology; Lymphoma, Large B-Cell, Diffuse / genetics; Lymphoma, Large B-Cell, Diffuse / metabolism; Lymphoma, Large B-Cell, Diffuse / pathology; Male; Mutation; NF-kappa B / genetics; NF-kappa B / metabolism; Proto-Oncogene Proteins c-bcl-6; Transcriptome
TL;DR: These studies identify molecular similarities to h DLBCL that introduce pet dogs as a representative model of hDLBCL for future studies, including therapeutic clinical trials. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2013 journal article

Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data

Human Genomics, 7.

By: Y. Su, D. Nielsen , L. Zhu, K. Richards, S. Suter, M. Breen , A. Motsinger-Reif, J. Osborne

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Lymphoma Immunophenotype of Dogs Determined by Immunohistochemistry, Flow Cytometry, and Polymerase Chain Reaction for Antigen Receptor Rearrangements

Journal of Veterinary Internal Medicine, 27(6), 1509–1516.

By: L. Thalheim n, L. Williams n, L. Borst n , J. Fogle n & S. Suter n

author keywords: Cancer; Flow cytometry; Lineage; Lymph nodes; Specificity
MeSH headings : Animals; Area Under Curve; DNA / chemistry; DNA / genetics; Dog Diseases / immunology; Dogs; Female; Flow Cytometry / veterinary; Immunohistochemistry / veterinary; Immunophenotyping / methods; Immunophenotyping / veterinary; Lymph Nodes / immunology; Lymphoma / genetics; Lymphoma / immunology; Male; Polymerase Chain Reaction / veterinary; Receptors, Antigen / genetics; Receptors, Antigen / immunology; Reproducibility of Results; Retrospective Studies; Sensitivity and Specificity
TL;DR: Flow cytometry is superior to PARR in correctly predicting immunophenotypes when evaluating lymph nodes from dogs already diagnosed with B- or T-cell LSA and if fresh samples are not available for FC, PARR is an acceptable assay for determination of immunophenotype given its high specificity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2013 journal article

VH1-44 gene usage defines a subset of canine B-cell lymphomas associated with better patient survival

Veterinary Immunology and Immunopathology, 157(3-4), 125–130.

By: H. Chen n, G. Small *, A. Motsinger-Reif n, S. Suter n & K. Richards  n

author keywords: Immunoglobulin heavy chain variable region (VH); B-cell lymphoma; Diffuse large B-cell lymphoma; Survival; VH1-44
MeSH headings : Animals; Dog Diseases / genetics; Dog Diseases / immunology; Dog Diseases / mortality; Dogs / immunology; Humans; Immunoglobulin Heavy Chains / genetics; Immunoglobulin Variable Region / genetics; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / immunology; Lymphoma, B-Cell / mortality; Lymphoma, B-Cell / veterinary
TL;DR: It is found that VH1-44 was preferentially expressed in the majority of the 52 cBCLs as well as in themajority of the cDLBCL subset of patients, and may have functional implications for c BCL lymphomagenesis, in addition to being a useful prognostic biomarker. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

CD8+ clonality is associated with prolonged acute plasma viremia and altered mRNA cytokine profiles during the course of Feline Immunodeficiency Virus infection

Veterinary Immunology and Immunopathology, 152(3-4), 200–208.

By: M. Miller n, E. Thompson n, S. Suter n & J. Fogle n

author keywords: FIV; AIDS; CTL; CD8(+) clonality; PARR
MeSH headings : Animals; CD8 Antigens / metabolism; CD8-Positive T-Lymphocytes / immunology; Cat Diseases / genetics; Cat Diseases / immunology; Cats; Clonal Selection, Antigen-Mediated / genetics; Cytokines / genetics; Gene Rearrangement, T-Lymphocyte; Immunodeficiency Virus, Feline; Lentivirus Infections / genetics; Lentivirus Infections / immunology; Lentivirus Infections / veterinary; Male; RNA, Messenger / genetics; RNA, Messenger / metabolism; Transcriptome; Viremia / genetics; Viremia / immunology; Viremia / veterinary
TL;DR: Using PARR to assess changes in CD8(+) clonality during the progression from acute to chronic FIV infection may help to better characterize the factors which contribute to CD8 (+) anergy and lentiviral persistence. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2012 journal article

Cutaneous epitheliotropic lymphoma with dual CD3 and c-kit expression in a dog

VETERINARY CLINICAL PATHOLOGY, 41(4), 594–598.

By: K. Shiomitsu *, R. Bauer*, B. Grasperge *, S. Suter n & K. Waite*

author keywords: CD117; co-expression; receptor tyrosine kinase; round cell tumor
MeSH headings : Animals; Biopsy, Fine-Needle / veterinary; CD3 Complex / metabolism; Cell Differentiation; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Lip / metabolism; Lip / pathology; Louisiana; Lymph Nodes / metabolism; Lymph Nodes / pathology; Lymphoma, T-Cell / metabolism; Lymphoma, T-Cell / pathology; Lymphoma, T-Cell / veterinary; Proto-Oncogene Proteins c-kit / metabolism; Skin / metabolism; Skin / pathology; Skin Neoplasms / metabolism; Skin Neoplasms / pathology; Skin Neoplasms / veterinary
TL;DR: An 11-year-old 8.9-kg spayed female Boston Terrier presented for evaluation of a mucocutaneous tumor that had been biopsied, the diagnosis was cutaneous epitheliotropic T-cell lymphoma with co-expression of CD3 and c-kit by neoplastic lymphocytes, an unusual finding. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Collection of Peripheral Blood CD34+ Progenitor Cells from Healthy Dogs and Dogs Diagnosed with Lymphoproliferative Diseases Using a Baxter-Fenwal CS-3000 Plus Blood Cell Separator

Journal of Veterinary Internal Medicine, 25(6), 1406–1413.

By: S. Suter n

author keywords: Apheresis; Canine; Hematopoietic cell transplantation; Mononuclear cells
MeSH headings : Animals; Antigens, CD34 / metabolism; Cell Separation / instrumentation; Cell Separation / methods; Cell Separation / veterinary; Dog Diseases / pathology; Dogs; Female; Hematopoietic Stem Cells / metabolism; Leukapheresis / instrumentation; Leukapheresis / veterinary; Lymphoproliferative Disorders / blood; Lymphoproliferative Disorders / metabolism; Lymphoproliferative Disorders / veterinary; Male; Reproducibility of Results
TL;DR: Canine PBMC apheresis using the Baxter-Fenwal CS-3000 Plus cell separator with an SVSCH and SVCC is a feasible and safe option for harvesting an adequate number of CD34+ peripheral blood progenitor cells from dogs weighing ≥17 kg for hematopoietic cell transplantation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Crossref
Added: July 27, 2019

2011 journal article

Diagnosis of intraocular lymphosarcoma in a dog by use of a polymerase chain reaction assay for antigen receptor rearrangement

Journal of the American Veterinary Medical Association, 238(5), 625–630.

By: D. Pate n, B. Gilger* , S. Suter* & A. Clode*

MeSH headings : Animals; Antineoplastic Agents / therapeutic use; Dog Diseases / diagnosis; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Eye Neoplasms / diagnosis; Eye Neoplasms / drug therapy; Eye Neoplasms / pathology; Eye Neoplasms / veterinary; Lymphoma, Non-Hodgkin / diagnosis; Lymphoma, Non-Hodgkin / drug therapy; Lymphoma, Non-Hodgkin / veterinary; Male; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Receptors, Antigen
TL;DR: In the dog of this report, intraocular lymphosarcoma was diagnosed via PARR performed on samples of aqueous humor and the immunophenotype of the neoplastic cells was determined by use of that diagnostic technique. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2011 journal article

FLT3 mutations in canine acute lymphocytic leukemia

BMC CANCER, 11.

By: S. Suter n, G. Small *, E. Seiser n, R. Thomas n, M. Breen n  & K. Richards *

Contributors: S. Suter n, G. Small *, E. Seiser n, R. Thomas n, M. Breen n  & K. Richards *

MeSH headings : Amino Acid Sequence; Animals; Blotting, Western; Carbazoles / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; DNA Mutational Analysis; DNA, Neoplasm / chemistry; DNA, Neoplasm / genetics; Disease Models, Animal; Dogs; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases / metabolism; Furans; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Molecular Sequence Data; Mutation; Phosphorylation / drug effects; Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics; Precursor Cell Lymphoblastic Leukemia-Lymphoma / metabolism; Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology; Reverse Transcriptase Polymerase Chain Reaction; STAT5 Transcription Factor / metabolism; fms-Like Tyrosine Kinase 3 / antagonists & inhibitors; fms-Like Tyrosine Kinase 3 / genetics; fms-Like Tyrosine Kinase 3 / metabolism
TL;DR: Results show that ALL andFLT3 biology is conserved between canine and human patients, supporting the notion that canine ALL, in conjunction with the GL-1 cell line, will be useful in the development of a relevant large animal model to aid in the study of human FLT3 mutant leukemias. (via Semantic Scholar)
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Hematologic Changes After Total Body Irradiation and Autologous Transplantation of Hematopoietic Peripheral Blood Progenitor Cells in Dogs With Lymphoma

VETERINARY PATHOLOGY, 49(2), 341–343.

By: C. Escobar  n, C. Grindem n, J. Neel n  & S. Suter n

Contributors: C. Escobar  n, C. Grindem n, J. Neel n  & S. Suter n

author keywords: clinical pathology; laboratory medicine; dog; hematopoietic; oncology
MeSH headings : Animals; Antigens, CD34 / metabolism; Blood Cell Count / veterinary; Bone Marrow / radiation effects; Dog Diseases / therapy; Dogs; Graft Survival; Hematopoietic Stem Cell Transplantation / methods; Hematopoietic Stem Cell Transplantation / veterinary; Lymphoma / therapy; Lymphoma / veterinary; Transplantation, Autologous; Whole-Body Irradiation / adverse effects; Whole-Body Irradiation / veterinary
TL;DR: This study documents the hematologic toxicities of total body irradiation in 10 dogs and the subsequent recovery of the affected cell lines after peripheral blood progenitor cell transplant, indicating successful CD34+ engraftment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Identification of Altered MicroRNA Expression in Canine Lymphoid Cell Lines and Cases of B- and T-Cell Lymphomas

GENES CHROMOSOMES & CANCER, 50(11), 950–967.

By: E. Uhl*, P. Krimer *, P. Schliekelman*, S. Tompkins * & S. Suter n

MeSH headings : Animals; Cell Line, Tumor; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Gene Expression Profiling / methods; Humans; Leukocytes, Mononuclear / metabolism; Lymph Nodes / metabolism; Lymphoma, B-Cell / genetics; Lymphoma, B-Cell / metabolism; Lymphoma, B-Cell / veterinary; Lymphoma, T-Cell / genetics; Lymphoma, T-Cell / metabolism; Lymphoma, T-Cell / veterinary; MicroRNAs / biosynthesis; MicroRNAs / genetics; Polymerase Chain Reaction
TL;DR: The findings of miRNA dysregulation in canine lymphoid cell lines and clinical cases of lymphoma emphasize the potential of canine lymphoma as an important spontaneous, large animal model of human B‐ and T‐cell lymphomas. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines

Veterinary and Comparative Oncology, 11(1), 30–50.

By: E. Seiser n, R. Thomas n, K. Richards  n, M. Kathryn Kelley n, P. Moore *, S. Suter n, M. Breen n 

Contributors: E. Seiser n, R. Thomas n, K. Richards  n, M. Kathryn Kelley n, P. Moore *, S. Suter n, M. Breen n 

author keywords: canine; cell line; comparative; lymphoid neoplasia; microarray; model
MeSH headings : Animals; Cell Line, Tumor; DNA / genetics; DNA / metabolism; Dog Diseases / metabolism; Dogs; Flow Cytometry; Gene Expression Regulation, Neoplastic / physiology; Karyotype; Lymphoma / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; RNA / genetics; RNA / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Transcriptome
TL;DR: Gene expression profiling and RT-PCR analyses defined the relationship between genomic imbalance and transcriptional dysregulation in each cell line, clarifying their relevance as models of discrete functional pathways with biological and therapeutic significance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas n, E. Seiser n, A. Motsinger-Reif*, L. Borst n , V. Valli*, K. Kelley n, S. Suter n, D. Argyle* ...

Contributors: R. Thomas n, E. Seiser n, A. Motsinger-Reif*, L. Borst n , V. Valli*, K. Kelley n, S. Suter n, D. Argyle* ...

author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR: It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2010 journal article

Evaluation of an in vitro telomeric repeat amplification protocol assay to detect telomerase activity in canine urine

American Journal of Veterinary Research, 71(12), 1468–1474.

By: A. McCleary-Wheeler  n, L. Williams n, P. Hess n  & S. Suter n

MeSH headings : Animals; Carcinoma, Transitional Cell / enzymology; Carcinoma, Transitional Cell / urine; Carcinoma, Transitional Cell / veterinary; Cell Line, Tumor; Dog Diseases / enzymology; Dog Diseases / urine; Dogs / urine; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Fibroblasts / enzymology; Lung / enzymology; Polymerase Chain Reaction / methods; Telomerase / analysis; Telomerase / urine; Telomere / genetics
TL;DR: The TRAP-based assay detected telomerase activity in the canine TCC cell line and revealed that the telomersase ribonucleoprotein complex was inherently unstable at various storage durations and conditions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Crossref, ORCID, NC State University Libraries
Added: July 20, 2019

2009 journal article

Canine cutaneous epitheliotropic T-cell lymphoma with vesiculobullous lesions resembling human bullous mycosis fungoides

Veterinary Dermatology, 20(4), 281–288.

By: P. Bizikova n, K. Linder n, S. Suter n, A. Van Wettere n & T. Olivry n 

Contributors: P. Bizikova n, K. Linder n, S. Suter n, A. Van Wettere n & T. Olivry n 

MeSH headings : Animals; Dog Diseases / pathology; Dogs; Lymphoma, T-Cell / pathology; Lymphoma, T-Cell / veterinary; Male; Skin Neoplasms / pathology; Skin Neoplasms / veterinary
TL;DR: Clonal rearrangement analysis of antigen receptor genes in samples from skin and lung lesions using primers specific for canine T- cell receptor gamma produced a single-sized amplicon of identical sequence, indicating that both lesions resulted from the expansion of the same neoplastic T-cell population. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018

2009 journal article

Sequential Low-Dose Rate Half-Body Irradiation and Chemotherapy for the Treatment of Canine Multicentric Lymphoma

Journal of Veterinary Internal Medicine, 23(5), 1064–1070.

By: D. Lurie *, I. Gordon*, A. Théon*, C. Rodriguez *, S. Suter n & M. Kent *

author keywords: Combination therapy; Dogs; Efficacy
MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Combined Modality Therapy; Cyclophosphamide / administration & dosage; Cyclophosphamide / adverse effects; Dog Diseases / drug therapy; Dog Diseases / pathology; Dog Diseases / radiotherapy; Dogs; Dose-Response Relationship, Radiation; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Female; Hematocrit / veterinary; Hemibody Irradiation / methods; Hemibody Irradiation / veterinary; Immunophenotyping / veterinary; Kaplan-Meier Estimate; Lymphoma / drug therapy; Lymphoma / pathology; Lymphoma / radiotherapy; Lymphoma / veterinary; Male; Prednisone / administration & dosage; Prednisone / adverse effects; Retrospective Studies; Vincristine / administration & dosage; Vincristine / adverse effects
TL;DR: Results of this study suggest that treatment intensification by a 2-week interradiation treatment interval coupled with interradiated chemotherapy is an effective treatment for dogs with lymphoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2009 journal article

Solitary Intracerebral Plasmacytoma in a Dog: Microscopic, Immunohistochemical, and Molecular Features

Veterinary Pathology, 46(5), 949–951.

By: A. Van Wettere n, K. Linder n, S. Suter n & N. Olby n 

author keywords: Brain neoplasia; canine; dogs; immunohistochemistry; plasma cell tumor; plasmacytoma; PCR
MeSH headings : Animals; Brain Neoplasms / pathology; Brain Neoplasms / veterinary; Dog Diseases / pathology; Dogs; Fatal Outcome; Female; Histocytochemistry / veterinary; Plasmacytoma / pathology; Plasmacytoma / veterinary; Seizures / pathology; Seizures / veterinary
TL;DR: Although primary solitary intracerebral plasmacytoma is rare in dogs and other species, it should be included in the differential diagnosis for central nervous system round-cell neoplasms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2009 journal article

Soy-Derived Isoflavones Inhibit the Growth of Canine Lymphoid Cell Lines

CLINICAL CANCER RESEARCH, 15(4), 1269–1276.

By: V. Jamadar-Shroff, M. Papich n  & S. Suter*

MeSH headings : Animals; Apoptosis / drug effects; Caspase 3 / physiology; Caspase 9 / physiology; Cell Line, Tumor; Cell Proliferation / drug effects; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Genistein / pharmacology; Lymphoma, B-Cell / drug therapy; Lymphoma, B-Cell / pathology; Lymphoma, B-Cell / veterinary; Male; Polysaccharides / pharmacology; Proto-Oncogene Proteins c-bcl-2 / analysis; bcl-2-Associated X Protein / analysis
TL;DR: The notion that canine high-grade B-cell lymphoma may represent a relevant large animal model of human non-Hodgkin's lymphoma to investigate the utility of GCP in chemopreventive and/or treatment strategies that may serve as a prelude to human clinical lymphoma trials is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Erythrophagocytic low-grade extranodal T-cell lymphoma in a cat

Veterinary Clinical Pathology, 37(4), 416–421.

By: J. Carter n, J. Tarigo n, W. Vernau n, T. Cecere n, R. Hovis n & S. Suter n

author keywords: Cat; erythrophagia; hepatosplenic; lymphoma; PARR
MeSH headings : Animals; Bone Marrow / metabolism; Cat Diseases / pathology; Cats; Liver / pathology; Lymphoma, T-Cell / pathology; Lymphoma, T-Cell / veterinary; Male; Spleen / pathology; Splenic Neoplasms / pathology; Splenic Neoplasms / veterinary
TL;DR: This report documents the first case of an erythrophagocytic T-cell lymphoma in a cat, a neoplasm described previously only in humans and dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, Crossref
Added: August 6, 2018

2008 journal article

Immunophenotypic and cytomorphologic subclassification of T-cell lymphoma in the boxer breed

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 125(1-2), 102–110.

By: D. Lurie *, R. Milner *, S. Suter n & W. Vernau*

author keywords: boxer; lymphoma; immunophenotype; cytomorphology
MeSH headings : Animals; Biopsy, Fine-Needle / veterinary; CD4 Antigens / blood; CD4 Antigens / immunology; CD8 Antigens / blood; CD8 Antigens / immunology; Dog Diseases / classification; Dog Diseases / drug therapy; Dog Diseases / immunology; Dogs; Female; Genetic Predisposition to Disease; Immunohistochemistry / veterinary; Immunophenotyping / veterinary; Kaplan-Meier Estimate; Lymphoma, T-Cell / classification; Lymphoma, T-Cell / drug therapy; Lymphoma, T-Cell / immunology; Lymphoma, T-Cell / veterinary; Male; Prospective Studies; Receptors, Antigen, T-Cell, alpha-beta / blood; Receptors, Antigen, T-Cell, alpha-beta / immunology; Receptors, Antigen, T-Cell, gamma-delta / blood; Receptors, Antigen, T-Cell, gamma-delta / immunology; Retrospective Studies
TL;DR: The results of this study indicate that lymphoma in the boxer breed is a disease comprised predominantly of TCRalphabeta+, CD4+ (helper) T-cells with lymphoblastic (high-grade) morphology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

CD34(+), CD41(+) acute megakaryoblastic leukemia in a dog

VETERINARY CLINICAL PATHOLOGY, 36(3), 288–292.

By: S. Suter*, W. Vernau, M. Fry & C. London

author keywords: acute megakaryoblastic leukemia; AML-M7; CD34; CD41; dog
MeSH headings : Animals; Antibodies / blood; Antibodies / isolation & purification; Antigens, CD34; Dog Diseases / diagnosis; Dog Diseases / immunology; Dog Diseases / pathology; Dogs; Female; Leukemia, Megakaryoblastic, Acute / diagnosis; Leukemia, Megakaryoblastic, Acute / immunology; Leukemia, Megakaryoblastic, Acute / pathology; Leukemia, Megakaryoblastic, Acute / veterinary; Platelet Membrane Glycoprotein IIb
TL;DR: This report documents the first case of canine AMegL diagnosed with both anti-canine CD34 and CD41 antibodies, and a diagnosis of acute megakaryoblastic leukemia (AMegL) was made in an intact female German Shepherd dog. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Marking of peripheral T-lymphocytes by retroviral transduction and transplantation of CD34(+) cells in a canine X-linked severe combined immunodeficiency model

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 117(3-4), 183–196.

By: S. Suter*, T. Gouthro*, T. O'Malley*, B. Hartnett*, P. McSweeney*, P. Moore *, P. Felsburg*, M. Haskins *, P. Henthorn*

author keywords: ex vivo gene therapy; hematopoietic progenitor cells; retroviral gene transfer; CD34(+)
MeSH headings : Animals; Antigens, CD34 / analysis; Bone Marrow Transplantation; Dogs; Flow Cytometry; Genetic Vectors; Green Fluorescent Proteins / genetics; Polymerase Chain Reaction; T-Lymphocytes / immunology; Transduction, Genetic; X-Linked Combined Immunodeficiency Diseases / immunology; X-Linked Combined Immunodeficiency Diseases / therapy
TL;DR: Marking experiments demonstrate that the transduction protocol did not abolish the lymphoid engraftment capability of ex vivo transduced canine CD34(+) cells and supports the potential utility of the MSCV retroviral vector for gene transfer to XSCID affected canine hematopoietic progenitor cells (HPC). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Prevalence of obese dogs in a population of dogs with cancer

American Journal of Veterinary Research, 68(4), 389–398.

By: L. Weeth*, A. Fascetti, P. Kass, S. Suter*, A. Santos & S. Delaney

MeSH headings : Animals; Body Constitution; California / epidemiology; Case-Control Studies; Dog Diseases / epidemiology; Dogs; Neoplasms / complications; Neoplasms / veterinary; Obesity / complications; Obesity / epidemiology; Obesity / veterinary; Prevalence; Retrospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2006 journal article

Optimized Transduction of Canine Paediatric CD34+ Cells Using an MSCV-based Bicistronic Vector

Veterinary Research Communications, 30(8), 881–901.

By: S. Suter*, T. Gouthro, P. McSweeney*, R. Nash *, M. Haskins *, P. Felsburg, P. Henthorn

author keywords: XSCID; CD34(+); retroviral transduction; amphotropic retrovirus; gamma c
MeSH headings : Animals; Antigens, CD34 / metabolism; Bone Marrow Cells / metabolism; Cell Line; Dogs; Fibroblasts; Genes / genetics; Genetic Vectors / genetics; Mice; Retroviridae / genetics; Stem Cells / virology; Thymus Gland / cytology; Transduction, Genetic / methods; Transduction, Genetic / veterinary
TL;DR: A murine MSCV-based bicistronic Retroviral vector, containing the common gamma chain (γc) and enhanced green fluorescent protein (EGFP) cDNAs, is used to optimize retroviral transduction of canine cells, including an adherent canine thymus fibroblast cell line, Cf2Th, as well as normal canine CD34+ bone marrow (BM) cells. (via Semantic Scholar)
Source: Crossref
Added: July 27, 2019

2005 journal article

803. The Effects of Intratumoral Injection of a Replicating Morbillivirus in a Canine Model of Naturally Occurring Lymphoma

Molecular Therapy, 11(Supplement 1), S312.

By: M. Henson, S. Suter*, V. von Messling, R. Cattaneo & A. Fielding

TL;DR: It is established that the non-pathogenic, vaccine strain of measles virus (MV) could cause regression of established lymphoma xenografts in mice and murine models have considerable limitations in predicting response in humans. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: December 29, 2020

2005 journal article

In vitro Canine Distemper Virus Infection of Canine Lymphoid Cells: A Prelude to Oncolytic Therapy for Lymphoma

Clinical Cancer Research, 11(4), 1579–1587.

By: S. Suter*

MeSH headings : Animals; Antigens, CD / genetics; Apoptosis; Cell Line, Tumor; Chlorocebus aethiops; Distemper Virus, Canine / genetics; Distemper Virus, Canine / growth & development; Dogs; Flow Cytometry; Gene Expression; Glycoproteins / genetics; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Humans; Immunoglobulins / genetics; Jurkat Cells; Lymphocytes / metabolism; Lymphocytes / virology; Lymphoma / therapy; Lymphoma / virology; Membrane Cofactor Protein; Membrane Glycoproteins / genetics; Plasmids / genetics; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Cell Surface; Reverse Transcriptase Polymerase Chain Reaction; Signaling Lymphocytic Activation Molecule Family Member 1; Transfection; Vero Cells
TL;DR: Dogs with lymphoma may represent a biologically relevant large animal model to investigate the feasibility, safety, and efficacy of Morbillivirus therapy in a clinical setting with findings that may have direct applicability in the treatment of human non-Hodgkin's lymphoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2004 journal article

Isolation and characterization of pediatric canine bone marrow CD34+ cells

Veterinary Immunology and Immunopathology, 101(1-2), 31–47.

By: S. Suter*, T. Gouthro*, P. McSweeney*, R. Nash *, M. Haskins *, P. Felsburg*, P. Henthorn*

author keywords: bone marrow transplantation; dog; CD; cytokines; ex vivo culture; hematopoiesis
MeSH headings : Age Factors; Animals; Animals, Newborn; Antigens, CD34 / immunology; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Bone Marrow Transplantation / immunology; Cell Division / immunology; Cystatin C; Cystatins / genetics; Cystatins / immunology; Dogs / immunology; Female; Genes, sry / genetics; Genes, sry / immunology; Immunomagnetic Separation / veterinary; Male; Proto-Oncogene Proteins c-kit / genetics; Proto-Oncogene Proteins c-kit / immunology; RNA / chemistry; RNA / genetics; Reverse Transcriptase Polymerase Chain Reaction; Severe Combined Immunodeficiency / veterinary
TL;DR: The demonstration of similarities between canine and human CD34+ cells enhances the dog as a large, preclinical model to evaluate strategies for improving bone marrow transplantation protocols, for gene therapy protocols that target CD34- cells, and to study the engraftment potential of various cell populations that may contain hematopoietic progenitor cell activity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

2002 journal article

Transplantation of X-linked severe combined immunodeficient dogs with CD34+ bone marrow cells

Biology of Blood and Marrow Transplantation, 8(4), 188–197.

By: B. Hartnett*, D. Yao*, S. Suter*, N. Ellinwood *, P. Henthorn*, P. Moore *, P. McSweeney*, R. Nash * ...

author keywords: canine; X-linked severe combined immunodeficiency CD34; bone marrow transplantation; immune reconstitution
MeSH headings : Animals; Antigens, CD34 / analysis; B-Lymphocytes / immunology; Bone Marrow Transplantation; Cell Lineage; Chimera; Dogs; Female; Genetic Linkage; Graft Survival; Interleukin Receptor Common gamma Subunit; Male; Models, Animal; Receptors, Interleukin-7 / deficiency; Receptors, Interleukin-7 / genetics; Severe Combined Immunodeficiency / genetics; Severe Combined Immunodeficiency / therapy; T-Lymphocytes / immunology; X Chromosome / genetics
TL;DR: Canine X-SCID provides a large-animal preclinical model that can be used not only to determine the optimal conditions for both donor B- and T-cell engraftment following CD34 BMT, but also to develop and evaluate strategies for gene therapy protocols that target CD34 cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: July 27, 2019

1997 journal article

Bone Marrow Transplantation (BMT) of X-SCID dogs with d c chain heterozygous bone marrow cells

Journal of Allergy and Clinical Immunology, V0099(414), 255.

By: B. Hartnett, S. Suter, P. Henthorn, K. Weinberg, P. Moore, H. Ochs, P. Felsburg

Source: NC State University Libraries
Added: September 9, 2019

1997 journal article

Full immunological reconstitution following non-conditional bone marrow transplantation for canine X-linked secure combined immunodeficiency

Blood, 90, 3212–3221.

By: P. Felsburg, R. Somberg, B. Hartnett, S. Suter, P. Henthorn, P. Moore, K. Weinberg, H. Ochs

Source: NC State University Libraries
Added: September 9, 2019

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