Sarah Quinlan

Works (2)

Updated: July 5th, 2023 14:41

2021 journal article

Canine Papillomavirus 2 E6 Does Not Interfere With UVB-Induced Upregulation of p53 and p53-Regulated Genes

FRONTIERS IN VETERINARY SCIENCE, 8.

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine papillomavirus type 2; E6; p53; LncRNA-p21; bak; bax
topics (OpenAlex): Veterinary Oncology Research; Virus-based gene therapy research; Cervical Cancer and HPV Research
TL;DR: It is determined that cutaneousCPV2 E6 does not degrade p53, or interfere with the upregulation of p53-regulated genes p21, Bax, Bak, or lncRNA-p21, suggesting that CPV2 may use a p53 -independent mechanism to contribute to oncogenesis. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: March 22, 2021

2020 journal article

Abrogation of Constitutive and Induced Type I and Type III Interferons and Interferon-Stimulated Genes in Keratinocytes by Canine Papillomavirus 2 E6 and E7

VIRUSES-BASEL, 12(6).

By: S. Quinlan n, S. May n, R. Weeks n, H. Yuan * & J. Luff n

author keywords: canine; papillomavirus; interferon; interferon-stimulated gene; E6; E7
MeSH headings : Animals; Cell Line; Dogs; Humans; Interferon-beta / metabolism; Keratinocytes / immunology; Keratinocytes / virology; Papillomaviridae / immunology; Papillomavirus E7 Proteins / genetics; Papillomavirus Infections / immunology; Papillomavirus Infections / pathology; Papillomavirus Infections / veterinary; Skin Neoplasms / virology
topics (OpenAlex): Cervical Cancer and HPV Research; Veterinary Oncology Research; Herpesvirus Infections and Treatments
TL;DR: It is determined that CPV2 E6 and E7 both impact expression of antiviral cytokines in canine keratinocytes, albeit likely through different mechanisms, and that E7 but not E6 abrogates signaling through the type I IFN receptor. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: August 17, 2020

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