Works (52)
Updated: August 29th, 2023 05:08
2023 article
A new role of TRPM8 in circadian rhythm and molecular clock
Mishra, S. K., & Gaddameedhi, S. (2023, January 20). ACTA PHYSIOLOGICA, Vol. 1.
MeSH headings : Circadian Rhythm; Circadian Clocks
Sources: ORCID, Web Of Science
Added: January 21, 2023
2023 journal article
The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study
F1000Research.
doi.org (publisher)
Source: ORCID
Added: June 29, 2023
2023 journal article
The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study
F1000Research.
Source: ORCID
Added: August 18, 2023
2023 journal article
The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 1; peer review: 1 approved, 1 approved with reservations]
[Version 1;]. F1000Research.
Contriutors: D. P. n, D. P. *, D. P., D. P., G. Shobhan n, G. Shobhan, G. Shobhan, G. Shobhan
Ed(s): D. P. n, G. Shobhan n, B. Koritala * & K. Porter *
MeSH headings : Humans; Male; Animals; Mice; Mice, Inbred C57BL; Circadian Rhythm; Circadian Clocks / genetics; Disease Models, Animal; Liver; Mammals
Source: ORCID
Added: August 3, 2023
2022 journal article
CIRCADIAN DYSREGULATION OF HUMAN DNA REPAIR GENES AND ELEVATED DNA DAMAGE IN SIMULATED NIGHT SHIFT SCHEDULE
Sleep. https://publons.com/wos-op/publon/54906417/
Contriutors: H. Van Dongen, B. Koritala, K. Porter, O. Arshad, R. Gajula, H. Mitchell, T. Arman, M. Manjanatha
Source: ORCID
Added: November 14, 2022
2022 journal article
Circadian disruption and cisplatin chronotherapy for mammary carcinoma
TOXICOLOGY AND APPLIED PHARMACOLOGY, 436.
Contriutors: B. Koritala *, K. Porter*, S. Sarkar * & *
author keywords: Chronotherapy; Cisplatin; Breast cancer; Clock disruption
MeSH headings : Animals; Breast Neoplasms / drug therapy; Cell Line; Chronotherapy / adverse effects; Circadian Clocks / drug effects; Circadian Rhythm / drug effects; Cisplatin / adverse effects; Cisplatin / pharmacology; Female; HEK293 Cells; Humans; Mammary Neoplasms, Animal / drug therapy; Mice; Mice, Inbred NOD
Sources: Web Of Science, ORCID
Added: May 23, 2022
2022 journal article
Circadian effects on UV-induced damage and mutations
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 789.
Contriutors: D. Goodenow*, A. Greer*, S. Cone* & *
author keywords: Circadian clock; Circadian rhythms; Skin clock; DNA damage; Ultraviolet radiation; Nucleotide excision repair; Mutagenesis; Skin cancer; Carcinogenesis
MeSH headings : Animals; Circadian Clocks / genetics; DNA Repair / genetics; Humans; Mammals; Mutation; Skin Neoplasms / genetics; Ultraviolet Rays / adverse effects
Sources: Web Of Science, ORCID
Added: May 2, 2022
2022 journal article
Endogenous Diurnal Patterns of Adrenal and Gonadal Hormones During a 24-Hour Constant Routine After Simulated Shift Work
JOURNAL OF THE ENDOCRINE SOCIETY, 6(12).
author keywords: circadian misalignment; healthy young adults; internal desynchrony; reproductive health; sex steroids
Sources: Web Of Science, ORCID
Added: November 14, 2022
2022 article
Let's talk about sex: A biological variable in immune response against melanoma
Dakup, P. P., Greer, A. J., & Gaddameedhi, S. (2022, February 3). PIGMENT CELL & MELANOMA RESEARCH, Vol. 35.
Contriutors: P. Dakup n, A. Greer n & n
author keywords: female; immune; male; melanoma; sex
MeSH headings : Female; Humans; Immunity; Male; Melanoma / genetics; Sex Characteristics; Sex Factors; Skin Neoplasms / genetics
Sources: ORCID, Web Of Science
Added: January 26, 2022
2022 journal article
Simulated Night- Shift Schedule Disrupts the Plasma Lipidome and Reveals Early Markers of Cardiovascular Disease Risk
NATURE AND SCIENCE OF SLEEP, 14, 981–994.
author keywords: lipidomics; mass spectrometry; circadian disruption; working time arrangements; cardiovascular health; triglycerides
Sources: Web Of Science, ORCID
Added: June 6, 2022
2022 journal article
Working around the Clock: Is a Person's Endogenous Circadian Timing for Optimal Neurobehavioral Functioning Inherently Task-Dependent?
CLOCKS & SLEEP, 4(1), 23–36.
Contriutors: R. Muck *, A. Hudson*, K. Honn *, n & H. Van Dongen *
author keywords: cognitive throughput; constant routine; inter-individual differences; simulated shift-work; sleep; wake homeostasis; subjective sleepiness; vigilant attention
Sources: Web Of Science, ORCID
Added: April 18, 2022
2021 article
Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells
Sarkar, S., Porter, K. I., Dakup, P. P., Gajula, R. P., Koritala, B. S. C., Hylton, R., … Gaddameedhi, S. (2021, July 6). PIGMENT CELL & MELANOMA RESEARCH, Vol. 34.
Contriutors: S. Sarkar *, K. Porter *, P. Dakup *, R. Gajula *, B. Koritala *, R. Hylton *, M. Kemp *, K. Wakamatsu *, *
author keywords: BMAL1; melanin; melanogenesis; MITF; ultraviolet radiation
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Animals; Gene Expression Regulation, Neoplastic; Humans; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mice; Microphthalmia-Associated Transcription Factor / genetics; Microphthalmia-Associated Transcription Factor / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism
Sources: Web Of Science, ORCID
Added: July 12, 2021
2021 journal article
Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia
NATURE COMMUNICATIONS, 12(1).
Contriutors: E. Hayter *, S. Wehrens *, H. Van Dongen *, A. Stangherlin *, n , E. Crooks *, N. Barron*, L. Venetucci*
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Adult; Animals; Arrhythmias, Cardiac / genetics; Arrhythmias, Cardiac / metabolism; Arrhythmias, Cardiac / physiopathology; Atrioventricular Node / metabolism; Atrioventricular Node / physiology; Autonomic Nervous System / physiology; Circadian Clocks / physiology; Circadian Rhythm / physiology; Electrocardiography; Female; Gene Expression Regulation / genetics; Gene Expression Regulation / physiology; Heart Rate / physiology; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / physiology; Sinoatrial Node / metabolism; Sinoatrial Node / physiology; Sleep / physiology
Sources: Web Of Science, ORCID
Added: June 10, 2021
2021 journal article
Night shift schedule alters endogenous regulation of circulating cytokines
Neurobiology of Sleep and Circadian Rhythms, 10, 100063.
Source: ORCID
Added: December 22, 2021
2021 journal article
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
JOURNAL OF PINEAL RESEARCH, 70(3).
Contriutors: B. Koritala *, K. Porter *, O. Arshad*, R. Gajula*, H. Mitchell *, T. Arman *, M. Manjanatha*, J. Teeguarden *
author keywords: circadian misalignment; genomic stability; hallmarks of cancer; shift work
MeSH headings : Activity Cycles; Adult; Biomarkers, Tumor / genetics; Chronobiology Disorders / etiology; Chronobiology Disorders / genetics; Chronobiology Disorders / physiopathology; Circadian Rhythm; DNA Damage; DNA Repair; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasms / etiology; Neoplasms / genetics; Neoplasms / pathology; Risk Assessment; Risk Factors; Shift Work Schedule / adverse effects; Sleep; Time Factors; Transcriptome; Young Adult
Sources: Web Of Science, ORCID
Added: April 5, 2021
2021 journal article
Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(26).
Contriutors: T. Xu *, D. Cheng*, Y. Zhao*, J. Zhang *, X. Zhu *, F. Zhang *, G. Chen *, Y. Wang *
author keywords: telomere and telomerase; hTERT gene; repetitive DNA elements; polymorphism and genetic diversities; human longevity
MeSH headings : Black or African American / genetics; Aged, 80 and over; Animals; Base Sequence; Cell Differentiation / genetics; Cell Line; Cell Proliferation / genetics; Chromosomes, Artificial, Bacterial / genetics; E-Box Elements / genetics; Genome, Human; Human Embryonic Stem Cells / metabolism; Humans; Mice, Nude; Minisatellite Repeats / genetics; Neoplasms / genetics; Neoplasms / pathology; Polymorphism, Genetic; Promoter Regions, Genetic; Protein Binding / genetics; Sequence Deletion / genetics; Telomerase / genetics; Telomere Homeostasis / genetics; Transcriptional Activation
Sources: Web Of Science, ORCID
Added: July 19, 2021
2020 journal article
Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(17).
Contriutors: A. Khalyfa *, n , E. Crooks *, C. Zhang *, Y. Li *, Z. Qiao *, W. Trzepizur *, S. Kay *
author keywords: Bmal1-dLuc reporter assay; circadian rhythm; clock genes; constant routine; exosomes; extracellular vesicles; hsa-mir-3614-5p; insulin resistance; night shift work; peripheral oscillators
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adult; Biomarkers / metabolism; Cells, Cultured; Circadian Rhythm / physiology; Circulating MicroRNA / analysis; Circulating MicroRNA / metabolism; Exosomes / genetics; Female; Gene Expression Regulation; Humans; Insulin Resistance; Male; RNA, Messenger; Signal Transduction
Sources: Web Of Science, ORCID
Added: October 5, 2020
2020 journal article
Sex differences in the association between tumor growth and T cell response in a melanoma mouse model
Cancer Immunology, Immunotherapy, 69(10), 2157–2162.
Contriutors: P. Dakup *, K. Porter *, A. Little *, H. Zhang * & *
author keywords: Melanoma; Sex differences; Male; Female; Immunity
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating / immunology; Male; Melanoma, Experimental / immunology; Melanoma, Experimental / pathology; Mice; Mice, Inbred C57BL; Skin Neoplasms / immunology; Skin Neoplasms / secondary; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / pathology; Tumor Burden; Tumor Cells, Cultured
Source: ORCID
Added: December 22, 2021
2020 journal article
Solar ultraviolet-induced DNA damage response: Melanocytes story in transformation to environmental melanomagenesis.
Environmental and Molecular Mutagenesis.
Contriutors: S. Sarkar * & *
author keywords: circadian clock; DDR signaling; ET-1; melanocytes; NER; solar UVB; alpha MSH
MeSH headings : Animals; DNA Damage / genetics; DNA Damage / radiation effects; DNA Repair / genetics; DNA Repair / radiation effects; Humans; Melanocytes / pathology; Melanocytes / radiation effects; Melanoma / pathology; Skin Neoplasms / pathology; Sunlight / adverse effects; Ultraviolet Rays / adverse effects
Source: ORCID
Added: December 24, 2021
2020 journal article
The circadian clock protects against acute radiation-induced dermatitis
Toxicology and Applied Pharmacology, 399, 115040.
Contriutors: P. Dakup *, K. Porter * & *
author keywords: Circadian Rhythm; Radiodermatitis; Toxicity; DNA Damage; BMAL1
MeSH headings : ARNTL Transcription Factors / genetics; Animals; Circadian Clocks / genetics; Circadian Rhythm / genetics; DNA Damage / genetics; DNA Damage / radiation effects; Female; Keratinocytes / radiation effects; Mice; Mice, Hairless; Neoplasms / genetics; Neoplasms / radiotherapy; Radiodermatitis / genetics
Source: ORCID
Added: December 22, 2021
2020 journal article
The circadian clock protects against ionizing radiation-induced cardiotoxicity.
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
Contriutors: P. Dakup *, K. Porter *, R. Gajula *, P. Goel*, Z. Cheng * & *
author keywords: Bmal1; circadian clock; heart; radiation; toxicity
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / genetics; Ataxia Telangiectasia Mutated Proteins / metabolism; BRCA1 Protein / genetics; BRCA1 Protein / metabolism; BRCA2 Protein / genetics; BRCA2 Protein / metabolism; Cell Line; DNA Damage; Mice; Mice, Inbred C57BL; Mutation; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / physiology; Myocytes, Cardiac / radiation effects; Period Circadian Proteins / genetics; Promoter Regions, Genetic; Radiation Injuries, Experimental / genetics; Radiation Injuries, Experimental / metabolism; Radiation, Ionizing; Rats; Systole
Source: ORCID
Added: December 24, 2021
2019 journal article
Cardiac autonomic activity during simulated shift work
Industrial Health.
Contriutors: E. Skornyakov*, * , G. Paech *, A. Sparrow*, B. Satterfield *, N. Shattuck*, M. Layton *, I. Karatsoreos *, H. Van Dongen *
author keywords: Night shift; Human sleep; Circadian misalignment; Parasympathetic nervous system; Sympathetic nervous system; Vagal tone; Heart rate variability
MeSH headings : Adult; Circadian Rhythm; Electrocardiography, Ambulatory; Exercise; Female; Heart Rate; Humans; Male; Shift Work Schedule / adverse effects; Young Adult
Source: ORCID
Added: December 24, 2021
2019 journal article
It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes
Yale Journal of Biology and Medicine. https://publons.com/wos-op/publon/32413204/
Source: ORCID
Added: November 14, 2022
2019 journal article
It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes.
The Yale Journal of Biology and Medicine. https://europepmc.org/articles/PMC6585512
Source: ORCID
Added: December 24, 2021
2018 journal article
Circadian clock protects against radiation-induced dermatitis and cardiomyopathy in mice
Cancer Research.
Contriutors: P. Dakup *, K. Porter *, Z. Cheng * & *
Source: ORCID
Added: November 14, 2022
2018 journal article
Circulating Plasma Exosomes May Signal Circadian Clock Misalignment to Peripheral Tissues
American Journal of Respiratory and Critical Care Medicine. https://publons.com/wos-op/publon/35726971/
Source: ORCID
Added: November 14, 2022
2018 journal article
Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism
Proceedings of the National Academy of Sciences, 115(30), 7825–7830.
Contriutors: D. Skene *, E. Skornyakov*, N. Chowdhury*, R. Gajula *, B. Middleton*, B. Satterfield *, K. Porter *, H. Van Dongen *, *
author keywords: circadian misalignment; gastrointestinal tract; liver; metabolomics; shift work
MeSH headings : Adult; Biological Clocks / physiology; Circadian Rhythm / physiology; Fasting / blood; Female; Gene Expression Regulation / physiology; Humans; Hydrocortisone / blood; Male; Melatonin / blood; Period Circadian Proteins / biosynthesis
Source: ORCID
Added: December 22, 2021
2018 journal article
The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models.
Oncotarget.
Source: ORCID
Added: December 24, 2021
2018 journal article
UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking.
The Journal of Investigative Dermatology.
Contriutors: S. Sarkar * & *
MeSH headings : Animals; Circadian Clocks; Erythema; Humans; Mice; Skin; Sunburn; Ultraviolet Rays
Source: ORCID
Added: December 24, 2021
2017 journal article
Chronopharmacology of cisplatin: role of the circadian rhythm in modulating cisplatin-induced toxicity in melanoma mouse model
Cancer Research.
Contriutors: P. Dakup *, K. Porter *, R. Gajula * & *
Source: ORCID
Added: November 14, 2022
2017 journal article
Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis
Photochemistry & Photobiology.
Contriutors: P. Dakup * & *
MeSH headings : Animals; Circadian Rhythm; DNA Damage; DNA Repair; Humans; Neoplasms, Radiation-Induced / metabolism; Neoplasms, Radiation-Induced / physiopathology; Oxidative Stress; Skin / metabolism; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / physiopathology; Ultraviolet Rays; Xeroderma Pigmentosum Group A Protein / metabolism
Source: ORCID
Added: December 24, 2021
2017 journal article
Shift Work: Disrupted Circadian Rhythms and Sleep-Implications for Health and Well-Being.
Current Sleep Medicine Reports.
Source: ORCID
Added: December 24, 2021
2016 journal article
Chronopharmacology of cisplatin: Role of the circadian rhythm in modulating the cisplatin transporters levels
The FASEB Journal. https://publons.com/wos-op/publon/32413213/
Source: ORCID
Added: November 14, 2022
2015 journal article
Circadian Clock, Cancer, and Chemotherapy
Biochemistry.
Contriutors: A. Sancar *, L. Lindsey-Boltz *, * , C. Selby *, R. Ye, Y. Chiou *, M. Kemp *, J. Hu *, J. Lee *, N. Ozturk *
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Circadian Clocks; DNA Damage / drug effects; DNA Repair / drug effects; DNA Repair Enzymes / metabolism; Drug Chronotherapy; Humans; Neoplasms / drug therapy; Neoplasms / epidemiology; Neoplasms / genetics; Neoplasms / metabolism; Risk Factors
Source: ORCID
Added: December 24, 2021
2015 journal article
Commentary: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Frontiers in Physiology.
Contriutors: R. Gajula * & *
author keywords: dark CPDs; melanin; melanoma; oxidative DNA damage; UV radiation
Source: ORCID
Added: December 24, 2021
2015 journal article
Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis.
Contriutors: M. Manjanatha *, S. Shelton*, Y. Chen *, * , P. Howard* & M. Boudreau*
author keywords: Transgenic Hairless albino mouse; gpt-Delta mouse; Spi(-) selection assay; Mutant frequency; Mutation frequency
MeSH headings : Animals; Dose-Response Relationship, Radiation; Epidermis / metabolism; Epidermis / radiation effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Female; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Transgenic / genetics; Models, Animal; Mutagenicity Tests; Mutation Rate; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Ultraviolet Rays
Source: ORCID
Added: December 24, 2021
2015 journal article
Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity.
Cancers.
author keywords: BRAF(V600E); melanocytes; UVB; melanoma
Source: ORCID
Added: December 24, 2021
2015 journal article
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin
Journal of Investigative Dermatology.
Contriutors: * , C. Selby *, M. Kemp *, R. Ye & A. Sancar *
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / metabolism; Circadian Clocks; Cytokines / metabolism; DNA Damage; DNA Repair; Erythema / etiology; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / metabolism; Sunburn; Time Factors; Ultraviolet Rays
Source: ORCID
Added: December 24, 2021
2014 journal article
DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
The Journal of Biological Chemistry.
Contriutors: M. Kemp *, * , J. Choi*, J. Hu * & A. Sancar *
MeSH headings : Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleus / metabolism; DNA / biosynthesis; DNA Cleavage; DNA Repair; Humans; Polydeoxyribonucleotides / metabolism; Replication Protein A / metabolism; Transcription Factor TFIIH / metabolism
Source: ORCID
Added: December 24, 2021
2014 journal article
Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock.
Genes & Development.
Contriutors: R. Ye, C. Selby *, Y. Chiou *, I. Ozkan-Dagliyan *, * & A. Sancar *
author keywords: circadian; Cryptochrome; Period; transcription; DNA binding
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Active Transport, Cell Nucleus; Animals; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Line; Circadian Clocks / genetics; Circadian Clocks / physiology; Cryptochromes / genetics; Cryptochromes / metabolism; Mice; Multiprotein Complexes; Mutation; Period Circadian Proteins / genetics; Period Circadian Proteins / metabolism; Protein Structure, Tertiary
Source: ORCID
Added: December 24, 2021
2014 journal article
Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells
Nucleic Acids Research.
Contriutors: J. Choi*, * , S. Kim *, J. Hu *, M. Kemp * & A. Sancar *
MeSH headings : Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; Humans; Kinetics; Luminescent Measurements / methods; Oligonucleotides; Pyrimidine Dimers / analysis; Ultraviolet Rays
Source: ORCID
Added: December 24, 2021
2013 journal article
DNA Damage-Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras-Transformed Cells
Cancer Research.
Contriutors: J. Lee *, * , N. Ozturk *, R. Ye & A. Sancar *
MeSH headings : Animals; Cell Death / genetics; Cell Line; Cell Transformation, Neoplastic / genetics; Circadian Rhythm / genetics; Cryptochromes / genetics; Cryptochromes / physiology; DNA Damage; DNA-Binding Proteins / genetics; Doxorubicin / toxicity; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagens / toxicity; Mutation; Nuclear Proteins / genetics; Organoplatinum Compounds / toxicity; Oxaliplatin; Tumor Protein p73; Tumor Suppressor Proteins / genetics; Ultraviolet Rays / adverse effects
Source: ORCID
Added: December 24, 2021
2013 journal article
Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo.
The Journal of Biological Chemistry.
Contriutors: J. Hu *, J. Choi*, * , M. Kemp *, J. Reardon* & A. Sancar *
MeSH headings : Animals; Cell Line; DNA Damage; DNA Repair / radiation effects; DNA-Binding Proteins / metabolism; Humans; Models, Biological; Mutation / genetics; Oligonucleotides / metabolism; Pyrimidine Dimers / metabolism; Transcription Factor TFIIH / metabolism; Transcription, Genetic / radiation effects; Ultraviolet Rays
Source: ORCID
Added: December 24, 2021
2012 journal article
Effect of circadian clock mutations on DNA damage response in mammalian cells.
Cell Cycle (Georgetown, Tex.).
Contriutors: * , J. Reardon*, R. Ye, N. Ozturk * & A. Sancar *
author keywords: Cryptochrome; Period; Clock; BMal1; DNA repair; checkpoint; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Apoptosis / genetics; Apoptosis / radiation effects; Ataxia Telangiectasia Mutated Proteins; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Cycle Checkpoints / drug effects; Cell Cycle Checkpoints / genetics; Cell Cycle Proteins / metabolism; Cell Line; Cell Survival / drug effects; Cell Survival / genetics; Cell Survival / radiation effects; Checkpoint Kinase 2; Circadian Clocks / drug effects; Circadian Clocks / genetics; Circadian Clocks / radiation effects; DNA Damage / genetics; DNA Repair / drug effects; DNA Repair / genetics; DNA Repair / radiation effects; DNA-Binding Proteins / metabolism; Down-Regulation / drug effects; Down-Regulation / genetics; Down-Regulation / radiation effects; Enzyme Activation / drug effects; Enzyme Activation / radiation effects; Feedback, Physiological / drug effects; Feedback, Physiological / radiation effects; Humans; Mammals / genetics; Mammals / physiology; Mice; Mitomycin / pharmacology; Mutation / genetics; Protein Serine-Threonine Kinases / metabolism; Radiation, Ionizing; Tumor Suppressor Proteins / metabolism; Ultraviolet Rays
Source: ORCID
Added: December 24, 2021
2011 journal article
Control of skin cancer by the circadian rhythm
Proceedings of the National Academy of Sciences, 108(46), 18790–18795.
Contriutors: * , C. Selby, W. Kaufmann, R. Smart n & A. Sancar
author keywords: circadian clock; cryptochrome; sunbathing; tanning salons
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / physiopathology; Circadian Rhythm / physiology; DNA Damage; DNA Repair; Disease Models, Animal; Humans; Immunohistochemistry / methods; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / radiation effects; Skin Neoplasms / etiology; Skin Neoplasms / physiopathology; Sunlight; Time Factors; Xeroderma Pigmentosum Group A Protein / biosynthesis; Xeroderma Pigmentosum Group A Protein / genetics
Sources: ORCID, Crossref
Added: February 24, 2020
2011 journal article
Melanoma and DNA damage from a distance (farstander effect).
Pigment Cell & Melanoma Research.
MeSH headings : Animals; Bystander Effect; Cell Cycle; DNA Damage; Humans; Melanoma / pathology; Mice; Models, Biological; Oxidation-Reduction
Source: ORCID
Added: December 24, 2021
2010 journal article
Similar nucleotide excision repair capacity in melanocytes and melanoma cells.
Cancer Research.
Contriutors: * , M. Kemp *, J. Reardon, J. Shields, S. Smith-Roe, W. Kaufmann, A. Sancar *
MeSH headings : Cells, Cultured; Collagen / metabolism; DNA Damage / radiation effects; DNA Repair; DNA, Neoplasm / radiation effects; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drug Combinations; Genes, ras / physiology; Humans; Laminin / metabolism; Melanocytes / physiology; Melanoma / genetics; Melanoma / metabolism; Mutation / genetics; Proteoglycans / metabolism; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins B-raf / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; Ultraviolet Rays
Source: ORCID
Added: December 24, 2021
2009 journal article
Association between the unfolded protein response, induced by 2-deoxyglucose, and hypersensitivity to cisplatin: a mechanistic study employing molecular genomics.
Journal of Cancer Research and Therapeutics.
Contriutors: * & S. Chatterjee *
author keywords: Apoptosis; cisplatin sensitivity; glucose-regulated stress protein of molecular weight 78 kDa; unfolded protein response; 2-deoxyglucose
MeSH headings : Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Apoptosis / genetics; Blotting, Western; Cell Line, Tumor; Cisplatin / pharmacology; DNA Fragmentation / drug effects; Deoxyglucose / pharmacology; Drug Resistance, Neoplasm / genetics; Endoplasmic Reticulum Chaperone BiP; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins / metabolism; Humans; Oligonucleotide Array Sequence Analysis; Signal Transduction / genetics; Unfolded Protein Response / drug effects; Unfolded Protein Response / genetics
Source: ORCID
Added: December 24, 2021
2009 journal article
Loss of cryptochrome reduces cancer risk in p53 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America.
Contriutors: N. Ozturk *, J. Lee *, * & A. Sancar *
author keywords: apoptosis; circadian clock; DNA repair
MeSH headings : Animals; Cell Transformation, Neoplastic / genetics; Cryptochromes; Female; Flavoproteins / genetics; Genes, p53; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Mutant Strains; Neoplasms, Experimental / genetics
Source: ORCID
Added: December 24, 2021
2008 journal article
Deciphering the association between up-regulation of glucose regulated protein of Mr-78 kDa (GRP78) and hypersensitivity to cisplatin employing comparative genomics
The FASEB Journal. https://publons.com/wos-op/publon/54906423/
Source: ORCID
Added: November 14, 2022
2006 journal article
Up-regulation of glucose regulated protein of M-r-78KDa (GRP78) followed by cisplatin treatment leads to mitochondrial mediated apoptosis through caspase-2 activation
Cancer Research. https://publons.com/wos-op/publon/54906422/
Source: ORCID
Added: November 14, 2022
2004 journal article
In-gel precipitation of enzymatically released phosphate.
Analytical Biochemistry.
Contriutors: A. Simonovic *, * & M. Anderson *
author keywords: acid phosphatase; alkaline phosphatase; ammonium molybdate; apyrase; gel-based assay; glutamine synthetase; inorganic phosphate; maltose phosphorylase; native PAGE; orthophosphate; precipitation; triethylamine
MeSH headings : Chemical Precipitation; Gels; Glucosyltransferases / metabolism; Glutamate-Ammonia Ligase / isolation & purification; Glutamate-Ammonia Ligase / metabolism; Hydrogen-Ion Concentration; Hydrolases / metabolism; Isoenzymes / isolation & purification; Isoenzymes / metabolism; Phosphates / chemistry; Phosphates / metabolism; Sensitivity and Specificity; Substrate Specificity
Source: ORCID
Added: December 24, 2021
Employment
Updated: September 11th, 2020 08:09
North Carolina State University Raleigh, NC, US
