Works (54)
Updated: April 23rd, 2024 05:03
2024 journal article
Inspiring basic and applied research in genome integrity mechanisms: Dedication to Samuel H. Wilson
Environmental and Molecular Mutagenesis.
Source: ORCID
Added: April 22, 2024
2023 article
A new role of TRPM8 in circadian rhythm and molecular clock
Mishra, S. K., & Gaddameedhi, S. (2023, January 20). ACTA PHYSIOLOGICA, Vol. 1.
MeSH headings : Circadian Rhythm; Circadian Clocks
TL;DR:
Evidence is provided that TRPM8 might regulate Period 2 (Per2) mRNA levels in central clock (SCN) and peripheral clock (liver and white adipose tissue) and the circadian regulation of core body temperature and the most significant advances in the field of circadian regulation using cold sensors are provided.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 21, 2023
2023 article
Telomere dysfunction in Tert knockout mice delays Braf<SUP>V600E</SUP>-induced melanoma development
Zhang, J., Zhang, F., Porter, K. I., Dakup, P. P., Wang, S., Robertson, G. P., … Zhu, J. (2023, September 20). INTERNATIONAL JOURNAL OF CANCER, Vol. 9.
author keywords: BRAF; melanoma; mouse model; telomerase; telomere dysfunction
TL;DR:
It is suggested that telomere dysfunction hampers melanomagenesis, and targeting telomeres crisis‐mediated genomic instability may hold promise for the prevention and treatment of melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 23, 2023
2023 journal article
The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study
F1000Research.
doi.org (publisher)
Source: ORCID
Added: June 29, 2023
2023 journal article
The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study
F1000Research.
TL;DR:
The study findings indicate more pronounced disturbances in the canonical clock genes of the skin compared to the liver under simulated shift-work light conditions, suggesting that the skin clock is more vulnerable to the effects of shift- work.
(via Semantic Scholar)
Source: ORCID
Added: August 18, 2023
2023 journal article
The impact of shift-work light conditions on tissue-specific circadian rhythms of canonical clock genes: insights from a mouse model study [version 1; peer review: 1 approved, 1 approved with reservations]
[Version 1;]. F1000Research.
Contributors: D. P. n, D. P. *, D. P., D. P., G. Shobhan n, G. Shobhan, G. Shobhan, G. Shobhan
Ed(s): D. P. n, G. Shobhan n, B. Koritala * & K. Porter *
MeSH headings : Humans; Male; Animals; Mice; Mice, Inbred C57BL; Circadian Rhythm; Circadian Clocks / genetics; Disease Models, Animal; Liver; Mammals
Source: ORCID
Added: August 3, 2023
2022 journal article
CIRCADIAN DYSREGULATION OF HUMAN DNA REPAIR GENES AND ELEVATED DNA DAMAGE IN SIMULATED NIGHT SHIFT SCHEDULE
Sleep. https://publons.com/wos-op/publon/54906417/
Contributors: H. Van Dongen, B. Koritala, K. Porter, O. Arshad, R. Gajula, H. Mitchell, T. Arman, M. Manjanatha
Source: ORCID
Added: November 14, 2022
2022 journal article
Circadian disruption and cisplatin chronotherapy for mammary carcinoma
TOXICOLOGY AND APPLIED PHARMACOLOGY, 436.
Contributors: B. Koritala *, K. Porter*, S. Sarkar * & *
author keywords: Chronotherapy; Cisplatin; Breast cancer; Clock disruption
MeSH headings : Animals; Breast Neoplasms / drug therapy; Cell Line; Chronotherapy / adverse effects; Circadian Clocks / drug effects; Circadian Rhythm / drug effects; Cisplatin / adverse effects; Cisplatin / pharmacology; Female; HEK293 Cells; Humans; Mammary Neoplasms, Animal / drug therapy; Mice; Mice, Inbred NOD
TL;DR:
The observations suggest that the effectiveness of cisplatin in mammary carcinoma treatment is time-dependent in the presence of the circadian clock, which is a potential strategy to reduce drug toxicity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 23, 2022
2022 journal article
Circadian effects on UV-induced damage and mutations
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 789.
Contributors: D. Goodenow*, A. Greer*, S. Cone* & *
author keywords: Circadian clock; Circadian rhythms; Skin clock; DNA damage; Ultraviolet radiation; Nucleotide excision repair; Mutagenesis; Skin cancer; Carcinogenesis
MeSH headings : Animals; Circadian Clocks / genetics; DNA Repair / genetics; Humans; Mammals; Mutation; Skin Neoplasms / genetics; Ultraviolet Rays / adverse effects
TL;DR:
This in-depth review will detail the mechanisms of the circadian clock and its role in cellular homeostasis, the skin's response to UVR exposure and its induction of DNA damage and mutations, as well as the impact of these factors on human health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 2, 2022
2022 journal article
Endogenous Diurnal Patterns of Adrenal and Gonadal Hormones During a 24-Hour Constant Routine After Simulated Shift Work
JOURNAL OF THE ENDOCRINE SOCIETY, 6(12).
author keywords: circadian misalignment; healthy young adults; internal desynchrony; reproductive health; sex steroids
TL;DR:
Experimental circadian misalignment had minimal effects on steroidogenesis and adrenal steroids, but not gonadal hormones, showed endogenous circadian regulation robust to prior shift schedule, which may predispose night-shift workers to metabolic ill health.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: November 14, 2022
2022 article
Let's talk about sex: A biological variable in immune response against melanoma
Dakup, P. P., Greer, A. J., & Gaddameedhi, S. (2022, February 3). PIGMENT CELL & MELANOMA RESEARCH, Vol. 35.
Contributors: P. Dakup n, A. Greer n & n
author keywords: female; immune; male; melanoma; sex
MeSH headings : Female; Humans; Immunity; Male; Melanoma / genetics; Sex Characteristics; Sex Factors; Skin Neoplasms / genetics
TL;DR:
A review of epidemiological evidence of sex differences in melanoma and the landscape of their potential origin makes a note of sex‐specific immune profiles—along with divergent hormonal regulation, social practices, DNA damage and oxidative stress responses, body composition, genetic variants, and X‐chromosome expression—as probable drivers of disparity in melan cancer initiation and progression.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
10. Reduced Inequalities
(OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 26, 2022
2022 journal article
Simulated Night- Shift Schedule Disrupts the Plasma Lipidome and Reveals Early Markers of Cardiovascular Disease Risk
NATURE AND SCIENCE OF SLEEP, 14, 981–994.
Contributors: J. Kyle *, L. Bramer *, D. Claborne, K. Stratton *, K. Bloodsworth *, J. Teeguarden *, n , T. Metz *, H. Van Dongen *
author keywords: lipidomics; mass spectrometry; circadian disruption; working time arrangements; cardiovascular health; triglycerides
TL;DR:
The simulated night-shift schedule was associated with altered temporal patterns in the lipidome, which may be premorbid to the elevated cardiovascular risk that has been found epidemiologically in night- shift workers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 6, 2022
2022 journal article
Working around the Clock: Is a Person's Endogenous Circadian Timing for Optimal Neurobehavioral Functioning Inherently Task-Dependent?
CLOCKS & SLEEP, 4(1), 23–36.
Contributors: R. Muck *, A. Hudson*, K. Honn *, n & H. Van Dongen *
author keywords: cognitive throughput; constant routine; inter-individual differences; simulated shift-work; sleep; wake homeostasis; subjective sleepiness; vigilant attention
TL;DR:
The results suggest that neurobehavioral functions are under top-down circadian control, consistent with the way they are accounted for in extant biomathematical models.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 18, 2022
2021 article
Circadian clock protein BMAL1 regulates melanogenesis through MITF in melanoma cells
Sarkar, S., Porter, K. I., Dakup, P. P., Gajula, R. P., Koritala, B. S. C., Hylton, R., … Gaddameedhi, S. (2021, July 6). PIGMENT CELL & MELANOMA RESEARCH, Vol. 34.
Contributors: S. Sarkar *, K. Porter *, P. Dakup *, R. Gajula*, B. Koritala *, R. Hylton *, M. Kemp *, K. Wakamatsu *, *
author keywords: BMAL1; melanin; melanogenesis; MITF; ultraviolet radiation
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Animals; Gene Expression Regulation, Neoplastic; Humans; Melanoma / genetics; Melanoma / metabolism; Melanoma / pathology; Mice; Microphthalmia-Associated Transcription Factor / genetics; Microphthalmia-Associated Transcription Factor / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism
TL;DR:
Novel insights are provided to the mechanistic role of the circadian clock in melanin synthesis and protection against UVB mediated DNA damage and genomic instability.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 12, 2021
2021 journal article
Distinct circadian mechanisms govern cardiac rhythms and susceptibility to arrhythmia
NATURE COMMUNICATIONS, 12(1).
Contributors: E. Hayter *, S. Wehrens *, H. Van Dongen *, A. Stangherlin *, n , E. Crooks *, N. Barron*, L. Venetucci*
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Adult; Animals; Arrhythmias, Cardiac / genetics; Arrhythmias, Cardiac / metabolism; Arrhythmias, Cardiac / physiopathology; Atrioventricular Node / metabolism; Atrioventricular Node / physiology; Autonomic Nervous System / physiology; Circadian Clocks / physiology; Circadian Rhythm / physiology; Electrocardiography; Female; Gene Expression Regulation / genetics; Gene Expression Regulation / physiology; Heart Rate / physiology; Humans; Male; Mice; Mice, Transgenic; Middle Aged; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / physiology; Sinoatrial Node / metabolism; Sinoatrial Node / physiology; Sleep / physiology
TL;DR:
It is demonstrated that circadian clocks within the brain and heart set daily rhythms in sinoatrial and atrioventricular node activity, and impose a time-of-day dependent susceptibility to ventricular arrhythmia.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021
2021 journal article
Night shift schedule alters endogenous regulation of circulating cytokines
Neurobiology of Sleep and Circadian Rhythms, 10, 100063.
TL;DR:
The results indicate that night shift work compromises host defense by creating cytokine conditions that initially impede anti-viral immunity (lower TNF-α) and may eventually promote autoimmunity (mistimed rise in IL-6).
(via Semantic Scholar)
Source: ORCID
Added: December 22, 2021
2021 journal article
Night shift schedule causes circadian dysregulation of DNA repair genes and elevated DNA damage in humans
JOURNAL OF PINEAL RESEARCH, 70(3).
Contributors: B. Koritala *, K. Porter *, O. Arshad*, R. Gajula*, H. Mitchell *, T. Arman*, M. Manjanatha*, J. Teeguarden *
author keywords: circadian misalignment; genomic stability; hallmarks of cancer; shift work
MeSH headings : Activity Cycles; Adult; Biomarkers, Tumor / genetics; Chronobiology Disorders / etiology; Chronobiology Disorders / genetics; Chronobiology Disorders / physiopathology; Circadian Rhythm; DNA Damage; DNA Repair; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Male; Neoplasms / etiology; Neoplasms / genetics; Neoplasms / pathology; Risk Assessment; Risk Factors; Shift Work Schedule / adverse effects; Sleep; Time Factors; Transcriptome; Young Adult
TL;DR:
The results suggest that circadian dysregulation of DNA repair may increase DNA damage and potentiate elevated cancer risk in night shift workers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 5, 2021
2021 journal article
Polymorphic tandem DNA repeats activate the human telomerase reverse transcriptase gene
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(26).
Contributors: T. Xu *, D. Cheng*, Y. Zhao*, J. Zhang *, X. Zhu *, F. Zhang *, G. Chen *, Y. Wang *
author keywords: telomere and telomerase; hTERT gene; repetitive DNA elements; polymorphism and genetic diversities; human longevity
MeSH headings : Black or African American / genetics; Aged, 80 and over; Animals; Base Sequence; Cell Differentiation / genetics; Cell Line; Cell Proliferation / genetics; Chromosomes, Artificial, Bacterial / genetics; E-Box Elements / genetics; Genome, Human; Human Embryonic Stem Cells / metabolism; Humans; Mice, Nude; Minisatellite Repeats / genetics; Neoplasms / genetics; Neoplasms / pathology; Polymorphism, Genetic; Promoter Regions, Genetic; Protein Binding / genetics; Sequence Deletion / genetics; Telomerase / genetics; Telomere Homeostasis / genetics; Transcriptional Activation
TL;DR:
An intronic variable number tandem repeat element, VNTR2-1, is identified as an enhancer-like element, which activated hTERT transcription in a cell in a chromatin-dependent manner, and is likely a missing link in the telomerase regulatory network and a molecular basis for genetic diversities of telomere homeostasis and age-related disease susceptibilities.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 19, 2021
2020 journal article
Circulating Exosomal miRNAs Signal Circadian Misalignment to Peripheral Metabolic Tissues
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(17).
Contributors: A. Khalyfa *, n , E. Crooks *, C. Zhang *, Y. Li *, Z. Qiao *, W. Trzepizur *, S. Kay *
author keywords: Bmal1-dLuc reporter assay; circadian rhythm; clock genes; constant routine; exosomes; extracellular vesicles; hsa-mir-3614-5p; insulin resistance; night shift work; peripheral oscillators
MeSH headings : Adipocytes / cytology; Adipocytes / metabolism; Adult; Biomarkers / metabolism; Cells, Cultured; Circadian Rhythm / physiology; Circulating MicroRNA / analysis; Circulating MicroRNA / metabolism; Exosomes / genetics; Female; Gene Expression Regulation; Humans; Insulin Resistance; Male; RNA, Messenger; Signal Transduction
TL;DR:
The results indicate that a simulated NS schedule leads to changes in exosomal cargo in the circulation that promote reduction of insulin sensitivity of adipocytes in vitro and alter the expression of core clock genes in peripheral tissues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 5, 2020
2020 journal article
Sex differences in the association between tumor growth and T cell response in a melanoma mouse model
Cancer Immunology, Immunotherapy, 69(10), 2157–2162.
Contributors: P. Dakup *, K. Porter *, A. Little *, H. Zhang * & *
author keywords: Melanoma; Sex differences; Male; Female; Immunity
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD4-Positive T-Lymphocytes / pathology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / pathology; Disease Models, Animal; Female; Lymphocytes, Tumor-Infiltrating / immunology; Male; Melanoma, Experimental / immunology; Melanoma, Experimental / pathology; Mice; Mice, Inbred C57BL; Skin Neoplasms / immunology; Skin Neoplasms / secondary; T-Lymphocytes, Cytotoxic / immunology; T-Lymphocytes, Cytotoxic / pathology; Tumor Burden; Tumor Cells, Cultured
TL;DR:
The results highlight a mouse model that represents melanoma progression in the human population and displays a higher immune response to melanoma in females compared to males, suggesting that the immune system may be one of the mechanisms responsible for sex differences in melanoma.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 22, 2021
2020 journal article
Solar ultraviolet-induced DNA damage response: Melanocytes story in transformation to environmental melanomagenesis.
Environmental and Molecular Mutagenesis.
Contributors: S. Sarkar * & *
author keywords: circadian clock; DDR signaling; ET-1; melanocytes; NER; solar UVB; alpha MSH
MeSH headings : Animals; DNA Damage / genetics; DNA Damage / radiation effects; DNA Repair / genetics; DNA Repair / radiation effects; Humans; Melanocytes / pathology; Melanocytes / radiation effects; Melanoma / pathology; Skin Neoplasms / pathology; Sunlight / adverse effects; Ultraviolet Rays / adverse effects
TL;DR:
NER is a well-studied DNA repair mechanism in the whole skin, as a tissue, but not much is known about it in melanocytes, so a specific focus on its functional regulators and their cross-talks are focused on, divulging the potential knowledge gap in the field.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2020 journal article
The circadian clock protects against acute radiation-induced dermatitis
Toxicology and Applied Pharmacology, 399, 115040.
Contributors: P. Dakup *, K. Porter * & *
author keywords: Circadian Rhythm; Radiodermatitis; Toxicity; DNA Damage; BMAL1
MeSH headings : ARNTL Transcription Factors / genetics; Animals; Circadian Clocks / genetics; Circadian Rhythm / genetics; DNA Damage / genetics; DNA Damage / radiation effects; Female; Keratinocytes / radiation effects; Mice; Mice, Hairless; Neoplasms / genetics; Neoplasms / radiotherapy; Radiodermatitis / genetics
TL;DR:
Findings suggest that the circadian clock plays a protective role in IR-induced DNA damage and skin toxicity, possibly through BMAL1-dependent mechanisms, and potentially impacts RT-associated radiodermatitis in cancer patients.
(via Semantic Scholar)
Source: ORCID
Added: December 22, 2021
2020 journal article
The circadian clock protects against ionizing radiation-induced cardiotoxicity.
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology.
Contributors: P. Dakup *, K. Porter *, R. Gajula*, P. Goel*, Z. Cheng * & *
author keywords: Bmal1; circadian clock; heart; radiation; toxicity
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / genetics; Ataxia Telangiectasia Mutated Proteins / metabolism; BRCA1 Protein / genetics; BRCA1 Protein / metabolism; BRCA2 Protein / genetics; BRCA2 Protein / metabolism; Cell Line; DNA Damage; Mice; Mice, Inbred C57BL; Mutation; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / physiology; Myocytes, Cardiac / radiation effects; Period Circadian Proteins / genetics; Promoter Regions, Genetic; Radiation Injuries, Experimental / genetics; Radiation Injuries, Experimental / metabolism; Radiation, Ionizing; Rats; Systole
TL;DR:
It is suggested that the circadian clock protects from IR‐induced toxicity and potentially impacts RT treatment outcome in cancer patients through IR‐ induced DNA damage responses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2019 journal article
Cardiac autonomic activity during simulated shift work
Industrial Health.
Contributors: E. Skornyakov*, * , G. Paech *, A. Sparrow*, B. Satterfield*, N. Shattuck*, M. Layton *, I. Karatsoreos *, H. Van Dongen *
author keywords: Night shift; Human sleep; Circadian misalignment; Parasympathetic nervous system; Sympathetic nervous system; Vagal tone; Heart rate variability
MeSH headings : Adult; Circadian Rhythm; Electrocardiography, Ambulatory; Exercise; Female; Heart Rate; Humans; Male; Shift Work Schedule / adverse effects; Young Adult
TL;DR:
The findings show systematic but complex, interacting effects of time of day, sleep/wake state, and physical activity on cardiac autonomic activity, and these effects need to be taken into account when evaluating HR and HRV in shift work settings and when interpreting these measures of cardiac autonomics activity as markers of cardiovascular disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2019 journal article
It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes
Yale Journal of Biology and Medicine. https://publons.com/wos-op/publon/32413204/
Source: ORCID
Added: November 14, 2022
2019 journal article
It's About Time: Advances in Understanding the Circadian Regulation of DNA Damage and Repair in Carcinogenesis and Cancer Treatment Outcomes.
The Yale Journal of Biology and Medicine. https://europepmc.org/articles/PMC6585512
Source: ORCID
Added: December 24, 2021
2018 journal article
Circadian clock protects against radiation-induced dermatitis and cardiomyopathy in mice
Cancer Research.
Contributors: P. Dakup *, K. Porter *, Z. Cheng * & *
TL;DR:
It is suggested that the healthy circadian clock protects the whole body, skin, and heart from RT-induced toxicity, and genotoxicity in blood cells were significantly increased in RS and Per1/2 -/- mice relative to DS mice.
(via Semantic Scholar)
Source: ORCID
Added: November 14, 2022
2018 journal article
Circulating Plasma Exosomes May Signal Circadian Clock Misalignment to Peripheral Tissues
American Journal of Respiratory and Critical Care Medicine. https://publons.com/wos-op/publon/35726971/
Source: ORCID
Added: November 14, 2022
2018 journal article
Separation of circadian- and behavior-driven metabolite rhythms in humans provides a window on peripheral oscillators and metabolism
Proceedings of the National Academy of Sciences, 115(30), 7825–7830.
Contributors: D. Skene *, E. Skornyakov*, N. Chowdhury *, R. Gajula*, B. Middleton*, B. Satterfield*, K. Porter *, H. Van Dongen *, *
author keywords: circadian misalignment; gastrointestinal tract; liver; metabolomics; shift work
MeSH headings : Adult; Biological Clocks / physiology; Circadian Rhythm / physiology; Fasting / blood; Female; Gene Expression Regulation / physiology; Humans; Hydrocortisone / blood; Male; Melatonin / blood; Period Circadian Proteins / biosynthesis
TL;DR:
It is found that rhythms in many metabolites implicated in food metabolism dissociated from the SCN pacemaker rhythm, with the vast majority aligning with the preceding sleep/wake and feeding/fasting cycles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: December 22, 2021
2018 journal article
The circadian clock regulates cisplatin-induced toxicity and tumor regression in melanoma mouse and human models.
Oncotarget.
TL;DR:
Cisplatin chronopharmacology involves the circadian clock control of DNA repair as well as immune responses, and thus affects both cisplatin toxicity and tumor growth, which has important implications for chronochemotherapy in cancer patients and also suggests that influencing the circadian Clock may be explored as a tool to improve patient outcomes.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2018 journal article
UV-B-Induced Erythema in Human Skin: The Circadian Clock Is Ticking.
The Journal of Investigative Dermatology.
Contributors: S. Sarkar * & *
MeSH headings : Animals; Circadian Clocks; Erythema; Humans; Mice; Skin; Sunburn; Ultraviolet Rays
TL;DR:
It is demonstrated that humans are more prone to sunburn erythema after evening exposure to solar UV-B radiation as compared with morning exposure.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2017 journal article
Chronopharmacology of cisplatin: role of the circadian rhythm in modulating cisplatin-induced toxicity in melanoma mouse model
Cancer Research.
Contributors: P. Dakup *, K. Porter *, R. Gajula* & *
TL;DR:
The initial findings strongly suggest that nephrotoxicity and DNA damage response function might be regulated by the circadian rhythm, and indicate a possible mechanism for the chronopharmacology of cisplatin in minimizing the toxicity associated with it.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: November 14, 2022
2017 journal article
Impact of the Circadian Clock on UV-Induced DNA Damage Response and Photocarcinogenesis
Photochemistry & Photobiology.
Contributors: P. Dakup * & *
MeSH headings : Animals; Circadian Rhythm; DNA Damage; DNA Repair; Humans; Neoplasms, Radiation-Induced / metabolism; Neoplasms, Radiation-Induced / physiopathology; Oxidative Stress; Skin / metabolism; Skin Neoplasms / etiology; Skin Neoplasms / metabolism; Skin Neoplasms / physiopathology; Ultraviolet Rays; Xeroderma Pigmentosum Group A Protein / metabolism
TL;DR:
Most studies of the circadian clock–NER connection have utilized murine models, and it is therefore important to translate these findings to humans to improve skin cancer prevention and chronotherapy.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2017 journal article
Shift Work: Disrupted Circadian Rhythms and Sleep-Implications for Health and Well-Being.
Current Sleep Medicine Reports.
TL;DR:
Interactions of biological disturbances with behavioral and societal factors shape the effects of shift work on health and well-being, and research is needed to better understand the underlying mechanisms and drive the development of countermeasures.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2016 journal article
Chronopharmacology of cisplatin: Role of the circadian rhythm in modulating the cisplatin transporters levels
The FASEB Journal. https://publons.com/wos-op/publon/32413213/
Source: ORCID
Added: November 14, 2022
2015 journal article
Circadian Clock, Cancer, and Chemotherapy
Biochemistry.
Contributors: A. Sancar *, L. Lindsey-Boltz *, * , C. Selby *, R. Ye, Y. Chiou *, M. Kemp *, J. Hu *, J. Lee *, N. Ozturk *
MeSH headings : Animals; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Circadian Clocks; DNA Damage / drug effects; DNA Repair / drug effects; DNA Repair Enzymes / metabolism; Drug Chronotherapy; Humans; Neoplasms / drug therapy; Neoplasms / epidemiology; Neoplasms / genetics; Neoplasms / metabolism; Risk Factors
TL;DR:
The circadian clock may affect the efficacy of cancer treatment by modulating the pharmacokinetics and pharmacodynamics of chemotherapeutic drugs as well as the activity of the DNA repair enzymes that repair the DNA damage caused by anticancer drugs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2015 journal article
Commentary: Chemiexcitation of melanin derivatives induces DNA photoproducts long after UV exposure.
Frontiers in Physiology.
author keywords: dark CPDs; melanin; melanoma; oxidative DNA damage; UV radiation
TL;DR:
It is found that UV induction of melanin contributes to melanomagenesis only by UVA and not by UVB radiation, which suggests that melanin might contribute to additional DNA damage and might further lead to increased risk of skin cancers.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2015 journal article
Development and validation of a new transgenic hairless albino mouse as a mutational model for potential assessment of photocarcinogenicity.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis.
Contributors: M. Manjanatha*, S. Shelton*, Y. Chen *, * , P. Howard* & M. Boudreau*
author keywords: Transgenic Hairless albino mouse; gpt-Delta mouse; Spi(-) selection assay; Mutant frequency; Mutation frequency
MeSH headings : Animals; Dose-Response Relationship, Radiation; Epidermis / metabolism; Epidermis / radiation effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Female; Male; Mice; Mice, Hairless; Mice, Inbred C57BL; Mice, Transgenic / genetics; Models, Animal; Mutagenicity Tests; Mutation Rate; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Ultraviolet Rays
TL;DR:
The results suggest that the newly developed THA mice are a useful and reliable model for testing UVB-induced mutagenicity in skin tissue and solar-induced skin carcinogenicity is presently under investigation.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2015 journal article
Oncogenic BRAF(V600E) Induces Clastogenesis and UVB Hypersensitivity.
Cancers.
author keywords: BRAF(V600E); melanocytes; UVB; melanoma
TL;DR:
It is demonstrated that expression of BRAF(V600E) is not only clastogenic, but synergizes for clastogenesis caused by exposure to ultraviolet radiation in the 300 to 320 nM (UVB) range and the importance of preventing sunburns in children with developing moles is emphasized.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2015 journal article
The Circadian Clock Controls Sunburn Apoptosis and Erythema in Mouse Skin
Journal of Investigative Dermatology.
Contributors: * , C. Selby *, M. Kemp *, R. Ye & A. Sancar *
MeSH headings : Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins / metabolism; Circadian Clocks; Cytokines / metabolism; DNA Damage; DNA Repair; Erythema / etiology; Immunohistochemistry; Inflammation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / metabolism; Skin / radiation effects; Skin Neoplasms / metabolism; Sunburn; Time Factors; Ultraviolet Rays
TL;DR:
Interestingly, it is observed that sunburn apoptosis, inflammatory cytokine induction, and erythema were maximal following an acute early morning exposure to UV and minimal following an afternoon exposure, the first evidence that the circadian clock plays an important role in the ery themal response in UV-irradiated skin.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2014 journal article
DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair.
The Journal of Biological Chemistry.
Contributors: M. Kemp *, * , J. Choi *, J. Hu * & A. Sancar *
MeSH headings : Cell Cycle Checkpoints; Cell Line, Tumor; Cell Nucleus / metabolism; DNA / biosynthesis; DNA Cleavage; DNA Repair; Humans; Polydeoxyribonucleotides / metabolism; Replication Protein A / metabolism; Transcription Factor TFIIH / metabolism
TL;DR:
It is demonstrated that sedDNAs are localized to the nucleus in two biochemically distinct forms, which include chromatin-associated, transcription factor II H-bound complexes and more readily solubilized, RPA-bound Complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 journal article
Dual modes of CLOCK:BMAL1 inhibition mediated by Cryptochrome and Period proteins in the mammalian circadian clock.
Genes & Development.
Contributors: R. Ye, C. Selby *, Y. Chiou *, I. Ozkan-Dagliyan *, * & A. Sancar *
author keywords: circadian; Cryptochrome; Period; transcription; DNA binding
MeSH headings : ARNTL Transcription Factors / genetics; ARNTL Transcription Factors / metabolism; Active Transport, Cell Nucleus; Animals; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Line; Circadian Clocks / genetics; Circadian Clocks / physiology; Cryptochromes / genetics; Cryptochromes / metabolism; Mice; Multiprotein Complexes; Mutation; Period Circadian Proteins / genetics; Period Circadian Proteins / metabolism; Protein Structure, Tertiary
TL;DR:
It is shown that CRY binds to CLOCK–BMAL1 at the promoter and inhibits CLock–BMal1-dependent transcription without dissociating the complex.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2014 journal article
Highly specific and sensitive method for measuring nucleotide excision repair kinetics of ultraviolet photoproducts in human cells
Nucleic Acids Research.
Contributors: J. Choi *, * , S. Kim *, J. Hu *, M. Kemp * & A. Sancar *
MeSH headings : Animals; Cell Line; Cricetinae; Cricetulus; DNA Repair; Humans; Kinetics; Luminescent Measurements / methods; Oligonucleotides; Pyrimidine Dimers / analysis; Ultraviolet Rays
TL;DR:
The novel approach is robust, with essentially no signal in the absence of UV or a functional excision repair system, and allows for the sensitive detection of excision products within minutes following UV irradiation and does not require additional enrichment steps such as immunoprecipitation.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2013 journal article
DNA Damage-Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras-Transformed Cells
Cancer Research.
Contributors: J. Lee *, * , N. Ozturk *, R. Ye & A. Sancar *
MeSH headings : Animals; Cell Death / genetics; Cell Line; Cell Transformation, Neoplastic / genetics; Circadian Rhythm / genetics; Cryptochromes / genetics; Cryptochromes / physiology; DNA Damage; DNA-Binding Proteins / genetics; Doxorubicin / toxicity; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagens / toxicity; Mutation; Nuclear Proteins / genetics; Organoplatinum Compounds / toxicity; Oxaliplatin; Tumor Protein p73; Tumor Suppressor Proteins / genetics; Ultraviolet Rays / adverse effects
TL;DR:
These findings establish distinct roles for cryptochromes in intrinsic apoptosis induced by UV mimetic and radiomimetic agents and Ras-transformed p53- and Cry-null mouse skin fibroblasts are more sensitive than p53 mutants to apoptotic cell death initiated by agents that activate either the intrinsic or the extrinsic apoptosis pathways.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2013 journal article
Nucleotide excision repair in human cells: fate of the excised oligonucleotide carrying DNA damage in vivo.
The Journal of Biological Chemistry.
Contributors: J. Hu *, J. Choi *, * , M. Kemp *, J. Reardon* & A. Sancar *
MeSH headings : Animals; Cell Line; DNA Damage; DNA Repair / radiation effects; DNA-Binding Proteins / metabolism; Humans; Models, Biological; Mutation / genetics; Oligonucleotides / metabolism; Pyrimidine Dimers / metabolism; Transcription Factor TFIIH / metabolism; Transcription, Genetic / radiation effects; Ultraviolet Rays
TL;DR:
It is demonstrated that dual incisions occur in vivo identical to the in vitro reaction, and the congruence of in vivo and in vitro data on nucleotide excision repair in humans is shown.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2012 journal article
Effect of circadian clock mutations on DNA damage response in mammalian cells.
Cell Cycle (Georgetown, Tex.).
Contributors: * , J. Reardon*, R. Ye, N. Ozturk * & A. Sancar *
author keywords: Cryptochrome; Period; Clock; BMal1; DNA repair; checkpoint; apoptosis
MeSH headings : Animals; Apoptosis / drug effects; Apoptosis / genetics; Apoptosis / radiation effects; Ataxia Telangiectasia Mutated Proteins; CLOCK Proteins / genetics; CLOCK Proteins / metabolism; Cell Cycle Checkpoints / drug effects; Cell Cycle Checkpoints / genetics; Cell Cycle Proteins / metabolism; Cell Line; Cell Survival / drug effects; Cell Survival / genetics; Cell Survival / radiation effects; Checkpoint Kinase 2; Circadian Clocks / drug effects; Circadian Clocks / genetics; Circadian Clocks / radiation effects; DNA Damage / genetics; DNA Repair / drug effects; DNA Repair / genetics; DNA Repair / radiation effects; DNA-Binding Proteins / metabolism; Down-Regulation / drug effects; Down-Regulation / genetics; Down-Regulation / radiation effects; Enzyme Activation / drug effects; Enzyme Activation / radiation effects; Feedback, Physiological / drug effects; Feedback, Physiological / radiation effects; Humans; Mammals / genetics; Mammals / physiology; Mice; Mitomycin / pharmacology; Mutation / genetics; Protein Serine-Threonine Kinases / metabolism; Radiation, Ionizing; Tumor Suppressor Proteins / metabolism; Ultraviolet Rays
TL;DR:
It is concluded that the majority of DNA damage response reactions are not controlled by the circadian clock or that, even if such a control exists at the organism level, it is supplanted by homeostatic control mechanisms at the cellular level in tissue culture.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2011 journal article
Control of skin cancer by the circadian rhythm
Proceedings of the National Academy of Sciences, 108(46), 18790–18795.
Contributors: * , C. Selby, W. Kaufmann*, R. Smart n & A. Sancar *
author keywords: circadian clock; cryptochrome; sunbathing; tanning salons
MeSH headings : Animals; Carcinoma, Squamous Cell / etiology; Carcinoma, Squamous Cell / physiopathology; Circadian Rhythm / physiology; DNA Damage; DNA Repair; Disease Models, Animal; Humans; Immunohistochemistry / methods; Mice; Mice, Inbred C57BL; Mice, Transgenic; Skin / radiation effects; Skin Neoplasms / etiology; Skin Neoplasms / physiopathology; Sunlight; Time Factors; Xeroderma Pigmentosum Group A Protein / biosynthesis; Xeroderma Pigmentosum Group A Protein / genetics
TL;DR:
It is concluded that time of day of exposure to UVR is a contributing factor to its carcinogenicity in mice, and possibly in humans.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: ORCID, Crossref, NC State University Libraries
Added: February 24, 2020
2011 journal article
Melanoma and DNA damage from a distance (farstander effect).
Pigment Cell & Melanoma Research.
MeSH headings : Animals; Bystander Effect; Cell Cycle; DNA Damage; Humans; Melanoma / pathology; Mice; Models, Biological; Oxidation-Reduction
TL;DR:
The paper shows that the same or similar mechanisms that are responsible for BE may cause systemic effects as well (farstander effect, FE) and suggests that S-phase cells of the skin and GIT are more sensitive to DSB formation through FE, as seen previously for BE in an IR-induced cell culture system.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2010 journal article
Similar nucleotide excision repair capacity in melanocytes and melanoma cells.
Cancer Research.
Contributors: * , M. Kemp *, J. Reardon*, J. Shields*, S. Smith-Roe *, W. Kaufmann*, A. Sancar *
MeSH headings : Cells, Cultured; Collagen / metabolism; DNA Damage / radiation effects; DNA Repair; DNA, Neoplasm / radiation effects; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Drug Combinations; Genes, ras / physiology; Humans; Laminin / metabolism; Melanocytes / physiology; Melanoma / genetics; Melanoma / metabolism; Mutation / genetics; Proteoglycans / metabolism; Proto-Oncogene Proteins B-raf / genetics; Proto-Oncogene Proteins B-raf / metabolism; Skin Neoplasms / genetics; Skin Neoplasms / metabolism; Tumor Suppressor Protein p53 / genetics; Tumor Suppressor Protein p53 / metabolism; Ultraviolet Rays
TL;DR:
It is concluded that melanoma cells retain capacity for nucleotide excision repair, the loss of which probably does not commonly contribute to melanoma progression.
(via Semantic Scholar)
Source: ORCID
Added: December 24, 2021
2009 journal article
Association between the unfolded protein response, induced by 2-deoxyglucose, and hypersensitivity to cisplatin: a mechanistic study employing molecular genomics.
Journal of Cancer Research and Therapeutics.
Contributors: * & S. Chatterjee *
author keywords: Apoptosis; cisplatin sensitivity; glucose-regulated stress protein of molecular weight 78 kDa; unfolded protein response; 2-deoxyglucose
MeSH headings : Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Apoptosis / genetics; Blotting, Western; Cell Line, Tumor; Cisplatin / pharmacology; DNA Fragmentation / drug effects; Deoxyglucose / pharmacology; Drug Resistance, Neoplasm / genetics; Endoplasmic Reticulum Chaperone BiP; Gene Expression; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Heat-Shock Proteins / metabolism; Humans; Oligonucleotide Array Sequence Analysis; Signal Transduction / genetics; Unfolded Protein Response / drug effects; Unfolded Protein Response / genetics
TL;DR:
It is shown that cisplatin treatment after the induction of UPR/GRP78 is facilitating the mitochondria-mediated apoptotic cascades through the initial activation of caspase-2 and down-regulation of genes involved in DNA repair.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2009 journal article
Loss of cryptochrome reduces cancer risk in p53 mutant mice.
Proceedings of the National Academy of Sciences of the United States of America.
Contributors: N. Ozturk *, J. Lee *, * & A. Sancar *
author keywords: apoptosis; circadian clock; DNA repair
MeSH headings : Animals; Cell Transformation, Neoplastic / genetics; Cryptochromes; Female; Flavoproteins / genetics; Genes, p53; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Mutant Strains; Neoplasms, Experimental / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: December 24, 2021
2008 journal article
Deciphering the association between up-regulation of glucose regulated protein of Mr-78 kDa (GRP78) and hypersensitivity to cisplatin employing comparative genomics
The FASEB Journal. https://publons.com/wos-op/publon/54906423/
Source: ORCID
Added: November 14, 2022
2006 journal article
Up-regulation of glucose regulated protein of M-r-78KDa (GRP78) followed by cisplatin treatment leads to mitochondrial mediated apoptosis through caspase-2 activation
Cancer Research. https://publons.com/wos-op/publon/54906422/
Source: ORCID
Added: November 14, 2022
2004 journal article
In-gel precipitation of enzymatically released phosphate.
Analytical Biochemistry.
Contributors: A. Simonovic *, * & M. Anderson *
author keywords: acid phosphatase; alkaline phosphatase; ammonium molybdate; apyrase; gel-based assay; glutamine synthetase; inorganic phosphate; maltose phosphorylase; native PAGE; orthophosphate; precipitation; triethylamine
MeSH headings : Chemical Precipitation; Gels; Glucosyltransferases / metabolism; Glutamate-Ammonia Ligase / isolation & purification; Glutamate-Ammonia Ligase / metabolism; Hydrogen-Ion Concentration; Hydrolases / metabolism; Isoenzymes / isolation & purification; Isoenzymes / metabolism; Phosphates / chemistry; Phosphates / metabolism; Sensitivity and Specificity; Substrate Specificity
TL;DR:
The phosphate precipitation reaction using ammonium molybdate and triethylamine under low pH has been applied to gel-based assays for detecting phosphate-releasing enzymes, a very simple, rapid, versatile, reproducible, and inexpensive method that could be a useful tool in enzymological studies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(OpenAlex)
Source: ORCID
Added: December 24, 2021
Employment
Updated: September 11th, 2020 08:09
North Carolina State University Raleigh, NC, US
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