Sophia Gray
Provost's Office
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Works (1)
Updated: April 5th, 2024 17:17
2023 journal article
C/EBP beta deficiency enhances the keratinocyte innate immune response to direct activators of cytosolic pattern recognition receptors
INNATE IMMUNITY, 29(1-2), 14–24.
author keywords: C/EBP beta; cell death; keratinocytes; type I IFN response
MeSH headings : Animals; Mice; Caspase 3 / metabolism; Caspase 8 / metabolism; CCAAT-Enhancer-Binding Protein-beta / genetics; Immunity, Innate; Interferon Type I / metabolism; Keratinocytes; Receptors, Pattern Recognition / genetics; Receptors, Pattern Recognition / metabolism
TL;DR:
The conditional deletion of C/EBPβ transcription factor in mouse epidermis resulted in the upregulation of IFNβ and numerous keratinocyte interferon-stimulated genes (ISGs) and the expression of cytosolic pattern recognition receptors (cPRRs), that recognize viral RNA and DNA, were significantly increased, and enriched in the RNAseq data set.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 30, 2023
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