Sean G. Smith

Works (4)

Updated: August 7th, 2023 21:17

2019 journal article

Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry

MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA, 36(2), 139–156.

By: S. Smith n, B. Griffith* & D. Zaharoff n

author keywords: bladder cancer; cystitis; intravesical delivery; FEBio
MeSH headings : Administration, Intravesical; Humans; Models, Theoretical; Urinary Bladder Diseases / drug therapy
TL;DR: The volume of instillation was found to have a substantial impact on the exposure of solute to the deeper muscle layers of the bladder, which are typically more difficult to reach and indicate the role that instillation volume may play in targeting particular layers ofThe bladder during an intravesical delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: November 18, 2019

2018 journal article

Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

BREAST CANCER RESEARCH, 20.

By: S. Ravindranathan *, K. Nguyen *, S. Kurtz*, H. Frazier*, S. Smith*, B. Koppolu*, N. Rajaram *, D. Zaharoff*

author keywords: Breast cancer vaccine; Autologous tumor cell vaccine; MDSCs; Breast cancer immunogenicity
MeSH headings : Animals; Breast / pathology; Breast Neoplasms / immunology; Breast Neoplasms / pathology; Breast Neoplasms / therapy; CRISPR-Cas Systems; Cancer Vaccines / administration & dosage; Cancer Vaccines / immunology; Cell Line, Tumor / immunology; Cell Line, Tumor / radiation effects; Cell Line, Tumor / transplantation; Disease Models, Animal; Female; Gene Deletion; Granulocyte Colony-Stimulating Factor / genetics; Granulocyte Colony-Stimulating Factor / immunology; Humans; Immunogenicity, Vaccine; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local / immunology; Neoplasm Recurrence, Local / prevention & control; Treatment Outcome
TL;DR: This study demonstrates that genetic ablation of immunosuppressive cytokines, such as G-CSF, can enhance the immunogenicity of breast cancer cell-based vaccines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: November 12, 2018

2017 journal article

Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer

ONCOIMMUNOLOGY, 6(1).

By: S. Smith n, J. Baltz*, B. Koppolu n, S. Ravindranathan *, K. Nguyen * & D. Zaharoff n

author keywords: BCG; bladder cancer; chitosan; immunotherapy; interleukin-12; intratumoral; intravesical; MDSC; TILS; TReg
TL;DR: The ability of properly delivered interleukin-12-based therapies to engage adaptive immunity within the tumor itself as well as throughout the body is demonstrated and the case for clinical translation of chitosan/interleuk in-12 as an intravesical treatment for bladder cancer is strengthened. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Modulation of Interleukin-12 activity in the presence of heparin

SCIENTIFIC REPORTS, 7.

By: S. Jayanthi *, B. Koppolu*, K. Nguyen *, S. Smith*, B. Felber *, T. Kumar*, D. Zaharoff n

MeSH headings : Biophysical Phenomena; Cell Line; Chromatography, Gel; Flow Cytometry; Heparin / metabolism; Heparitin Sulfate / metabolism; Humans; Immunologic Factors / metabolism; Interleukin-12 / chemistry; Interleukin-12 / metabolism; Interleukin-12 Subunit p35; Protein Binding; Protein Conformation / drug effects; Protein Multimerization / drug effects; Scattering, Small Angle
TL;DR: Results of this study demonstrate a new role for heparin in modulating the biological activity of IL-12, and Heparin modestly protected hIL-12 from proteolytic degradation, however, this was not a likely mechanism for increased cytokine activity in vitro. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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