Sean G. Smith

Works (4)

Updated: August 7th, 2023 21:17

2018 article

Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry

Smith, S. G., Griffith, B. E., & Zaharoff, D. A. (2018, March 22). Mathematical Medicine and Biology A Journal of the IMA.

By: S. Smith n, B. Griffith* & D. Zaharoff n

author keywords: bladder cancer; cystitis; intravesical delivery; FEBio
MeSH headings : Administration, Intravesical; Humans; Models, Theoretical; Urinary Bladder Diseases / drug therapy
topics (OpenAlex): Innovative Microfluidic and Catalytic Techniques Innovation; Pickering emulsions and particle stabilization; Advanced Drug Delivery Systems
TL;DR: The volume of instillation was found to have a substantial impact on the exposure of solute to the deeper muscle layers of the bladder, which are typically more difficult to reach and indicate the role that instillation volume may play in targeting particular layers ofThe bladder during an intravesical delivery. (via Semantic Scholar)
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Source: Web Of Science
Added: November 18, 2019

2018 article

Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines

Ravindranathan, S., Nguyen, K. G., Kurtz, S. L., Frazier, H. N., Smith, S. G., Koppolu, B., … Zaharoff, D. A. (2018, October 22). Breast Cancer Research.

By: S. Ravindranathan *, K. Nguyen *, S. Kurtz*, H. Frazier*, S. Smith n, B. Koppolu  n, N. Rajaram *, D. Zaharoff*

author keywords: Breast cancer vaccine; Autologous tumor cell vaccine; MDSCs; Breast cancer immunogenicity
MeSH headings : Animals; Breast / pathology; Breast Neoplasms / immunology; Breast Neoplasms / pathology; Breast Neoplasms / therapy; CRISPR-Cas Systems; Cancer Vaccines / administration & dosage; Cancer Vaccines / immunology; Cell Line, Tumor / immunology; Cell Line, Tumor / radiation effects; Cell Line, Tumor / transplantation; Disease Models, Animal; Female; Gene Deletion; Granulocyte Colony-Stimulating Factor / genetics; Granulocyte Colony-Stimulating Factor / immunology; Humans; Immunogenicity, Vaccine; Mice; Mice, Inbred BALB C; Neoplasm Recurrence, Local / immunology; Neoplasm Recurrence, Local / prevention & control; Treatment Outcome
topics (OpenAlex): Immune cells in cancer; Immunotherapy and Immune Responses; Cancer Immunotherapy and Biomarkers
TL;DR: This study demonstrates that genetic ablation of immunosuppressive cytokines, such as G-CSF, can enhance the immunogenicity of breast cancer cell-based vaccines. (via Semantic Scholar)
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Source: Web Of Science
Added: November 12, 2018

2017 article

Modulation of Interleukin-12 activity in the presence of heparin

Jayanthi, S., Koppolu, B., Nguyen, K. G., Smith, S. G., Felber, B. K., Kumar, T. K. S., & Zaharoff, D. A. (2017, July 7). Scientific Reports.

By: S. Jayanthi *, B. Koppolu n, K. Nguyen *, S. Smith n, B. Felber *, T. Kumar *, D. Zaharoff n

MeSH headings : Biophysical Phenomena; Cell Line; Chromatography, Gel; Flow Cytometry; Heparin / metabolism; Heparitin Sulfate / metabolism; Humans; Immunologic Factors / metabolism; Interleukin-12 / chemistry; Interleukin-12 / metabolism; Interleukin-12 Subunit p35; Protein Binding; Protein Conformation / drug effects; Protein Multimerization / drug effects; Scattering, Small Angle
topics (OpenAlex): Viral Infectious Diseases and Gene Expression in Insects; Monoclonal and Polyclonal Antibodies Research; Glycosylation and Glycoproteins Research
TL;DR: Results of this study demonstrate a new role for heparin in modulating the biological activity of IL-12, and Heparin modestly protected hIL-12 from proteolytic degradation, however, this was not a likely mechanism for increased cytokine activity in vitro. (via Semantic Scholar)
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Added: August 6, 2018

2016 article

Immunological mechanisms of intravesical chitosan/interleukin-12 immunotherapy against murine bladder cancer

Smith, S. G., Baltz, J. L., Koppolu, B. P., Ravindranathan, S., Nguyen, K., & Zaharoff, D. A. (2016, November 18). OncoImmunology.

By: S. Smith n, J. Baltz*, B. Koppolu n, S. Ravindranathan *, K. Nguyen * & D. Zaharoff n

author keywords: BCG; bladder cancer; chitosan; immunotherapy; interleukin-12; intratumoral; intravesical; MDSC; TILS; TReg
topics (OpenAlex): Bladder and Urothelial Cancer Treatments; Immune Cell Function and Interaction; Immunotherapy and Immune Responses
TL;DR: The ability of properly delivered interleukin-12-based therapies to engage adaptive immunity within the tumor itself as well as throughout the body is demonstrated and the case for clinical translation of chitosan/interleuk in-12 as an intravesical treatment for bladder cancer is strengthened. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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