Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity - Liu, Mengrui; Hu, Shiqi; Yan, Na; Popowski, Kristen D.; Cheng, Ke (NATURE NANOTECHNOLOGY, 2024)

Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2 - Wang, Zhenzhen; Hu, Shiqi; Popowski, Kristen D.; Liu, Shuo; Zhu, Dashuai; Mei, Xuan; Li, Junlang; Hu, Yilan; Dinh, Phuong-Uyen C.; Wang, Xiaojie; Cheng, Ke (NATURE COMMUNICATIONS, 2024)

A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus - Wang, Zhenzhen; Li, Zhenhua; Shi, Weiwei; Zhu, Dashuai; Hu, Shiqi; Dinh, Phuong-Uyen C.; Cheng, Ke (SCIENCE ADVANCES, 2023)

An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection - Mei, Xuan; Li, Junlang; Wang, Zhenzhen; Zhu, Dashuai; Huang, Ke; Hu, Shiqi; Popowski, Kristen D.; Cheng, Ke (Nature Materials, 2023)

Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials - Wang, Xianyun; Hu, Shiqi; Zhu, Dashuai; Li, Junlang; Cheng, Ke; Liu, Gang (NANO RESEARCH, 2023)
Keywords: nanovesicles (NVs); exosomes; cardiac repair; mesenchymal stem cells (MSCs); extracellular vesicles (EVs); myocardial infarction (Ml)

Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy - Cheng, Xiao; Hu, Shiqi; Cheng, Ke (ACS NANO, 2023)
Keywords: PROTAC; estrogen receptor; microneedle patch; hyaluronic acid gel; ER-positive breast cancer

Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair - Hu, Shiqi; Zhu, Dashuai; Li, Zhenhua; Cheng, Ke (ACS NANO, 2022)
Keywords: mesenchymal stromal cell; secreted factors; microneedle patch; elastin-like peptide gel; hyaluronic acid gel; myocardial infarction; cardiac repair

Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3 - Zhu, Dashuai; Liu, Shuo; Huang, Ke; Wang, Zhenzhen; Hu, Shiqi; Li, Junlang; Li, Zhenhua; Cheng, Ke (CIRCULATION RESEARCH, 2022)
Keywords: exosomes; immunomodulation; mesesnchymal stem cell; myocardial infarction; regulatory T cell

Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction - Li, Junlang; Lv, Yongbo; Zhu, Dashuai; Mei, Xuan; Huang, Ke; Wang, Xianyun; Li, Zhenhua; Zhang, Sichen; Hu, Shiqi; Popowski, Kristen D.; Cheng, Ke; Wang, Juan (CHEMICAL ENGINEERING JOURNAL, 2022)
Keywords: Mesenchymal stem cells; Hydrogel; Myocardial infarction; Intrapericardial; Intramyocardial

A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction - Yao, Jialu; Huang, Ke; Zhu, Dashuai; Chen, Tan; Jiang, Yufeng; Zhang, Junyi; Mi, Lijie; Xuan, He; Hu, Shiqi; Li, Junlang; Zhou, Yafeng; Cheng, Ke (ACS NANO, 2021)
Keywords: MSC; exosome; spray; myocardial infarction; heart repair

A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs - Mei, Xuan; Zhu, Dashuai; Li, Junlang; Huang, Ke; Hu, Shiqi; Li, Zhenhua; Abad, Blanca Lopez de Juan; Cheng, Ke (MED, 2021)

A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency - Zhang, Sichen; Zhu, Dashuai; Li, Zhenhua; Huang, Ke; Hu, Shiqi; Lutz, Halle; Xie, Mengjie; Mei, Xuan; Li, Junlang; Neal-Perry, Genevieve; Wang, Shaowei; Cheng, Ke (THERANOSTICS, 2021)
Keywords: primary ovarian insufficiency; ovarian regenerative patch; regenerative medicine; mesenchymal stem cells; acellular therapy; fertility

All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart - Li, Junlang; Hu, Shiqi; Zhu, Dashuai; Huang, Ke; Mei, Xuan; Abad, Blanca Lopez de Juan; Cheng, Ke (JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2021)
Keywords: cardiac repair; cell delivery; intracoronary; intramyocardial; intrapericardial; intravenous; retention rate

Exosome-eluting stents for vascular healing after ischaemic injury - Hu, Shiqi; Li, Zhenhua; Shen, Deliang; Zhu, Dashuai; Huang, Ke; Su, Teng; Dinh, Phuong-Uyen; Cores, Jhon; Cheng, Ke (NATURE BIOMEDICAL ENGINEERING, 2021)

Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair - Wang, Xianyun; Hu, Shiqi; Li, Junlang; Zhu, Dashuai; Wang, Zhenzhen; Cores, Jhon; Cheng, Ke; Liu, Gang; Huang, Ke (ACS APPLIED MATERIALS & INTERFACES, 2021)
Keywords: extrusion; nanovesicles; extracellular vesicles; mesenchymal stem cell; ischemia reperfusion injury

Generation and Manipulation of Exosomes - Hu, Shiqi; Qiao, Li; Cheng, Ke (CARDIAC REGENERATION, 2021)
Keywords: Exosome generation; Exosome manipulation; Myocardial infarction; Cardiac homing peptide; Platelet membrane; Intravenous injection

Injection of ROS-Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair - Li, Zhenhua; Zhu, Dashuai; Hui, Qi; Bi, Jianing; Yu, Bingjie; Huang, Zhen; Hu, Shiqi; Wang, Zhenzhen; Caranasos, Thomas; Rossi, Joseph; Li, Xiaokun; Cheng, Ke; et al. (ADVANCED FUNCTIONAL MATERIALS, 2021)
Keywords: bFGF; heart repair; intrapericardial delivery; pericardial cavity; ROS responsive hydrogels

Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury - Hu, Shiqi; Wang, Xianyun; Li, Zhenhua; Zhu, Dashuai; Cores, Jhon; Wang, Zhenzhen; Li, Junlang; Mei, Xuan; Cheng, Xiao; Su, Teng; Cheng, Ke (NANO TODAY, 2021)
Keywords: Exosomes; Targeting; Myocardial infarction; Platelet membrane; Stem cells

Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy - Zheng, Pengli; Fan, Miao; Liu, Huifang; Zhang, Yinghua; Dai, Xinyue; Li, Hang; Zhou, Xiaohan; Hu, Shiqi; Yang, Xinjian; Jin, Yi; Yu, Na; Guo, Shutao; et al. (ACS NANO, 2021)

Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs - Su, Teng; Huang, Ke; Mathews, Kyle G.; Scharf, Valery F.; Hu, Shiqi; Li, Zhenhua; Frame, Brianna N.; Cores, Jhon; Dinh, Phuong-Uyen; Daniele, Michael A.; Ligler, Frances S.; Cheng, Ke (ACS BIOMATERIALS SCIENCE & ENGINEERING, 2020)
Keywords: microfluidics; cardiac patch; cardiac stromal cells; myocardial infarction; porcine model

Dermal exosomes containing miR-218-5p promote hair regeneration by regulating beta-catenin signaling - Hu, Shiqi; Li, Zhenhua; Lutz, Halle; Huang, Ke; Su, Teng; Cores, Jhon; Dinh, Phuong-Uyen Cao; Cheng, Ke (SCIENCE ADVANCES, 2020)

Engineering better stem cell therapies for treating heart diseases - Li, Junlang; Hu, Shiqi; Cheng, Ke (ANNALS OF TRANSLATIONAL MEDICINE, 2020)
Keywords: Stem cell therapy; ischemic heart diseases; bioengineering strategies; clinical translation

Exosome therapeutics for lung regenerative medicine - Popowski, Kristen; Lutz, Halle; Hu, Shiqi; George, Arianna; Dinh, Phuong-Uyen; Cheng, Ke (JOURNAL OF EXTRACELLULAR VESICLES, 2020)
Keywords: Exosome; regenerative medicine; lung spheroid cell; stem cell

Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis - Dinh, Phuong-Uyen C.; Paudel, Dipti; Brochu, Hayden; Popowski, Kristen D.; Gracieux, M. Cyndell; Cores, Jhon; Huang, Ke; Hensley, M. Taylor; Harrell, Erin; Vandergriff, Adam C.; George, Arianna K.; Barrio, Raina T.; et al. (NATURE COMMUNICATIONS, 2020)

Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis - Liang, Hongxia; Li, Zhenhua; Ren, Zhigang; Jia, Qiaodi; Guo, Linna; Li, Shasha; Zhang, Hongyu; Hu, Shiqi; Zhu, Dashuai; Shen, Deliang; Yu, Zujiang; Cheng, Ke (NANO RESEARCH, 2020)
Keywords: liver fibrosis; nitric oxide (NO); hepatic stellate cells (HSC); nanoparticles; near infrared light (NIR)-controlled release

Targeted anti-IL-1 beta platelet microparticles for cardiac detoxing and repair - Li, Zhenhua; Hu, Shiqi; Huang, Ke; Su, Teng; Cores, Jhon; Cheng, Ke (SCIENCE ADVANCES, 2020)

Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs - Qiao, Li; Hu, Shiqi; Huang, Ke; Su, Teng; Li, Zhenhua; Vandergriff, Adam; Cores, Jhon; Dinh, Phuong-Uyen; Allen, Tyler; Shen, Deliang; Liang, Hongxia; Li, Yongjun; et al. (THERANOSTICS, 2020)
Keywords: exosome; homing; integrin; doxorubicin; cancer therapy

Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells - Shen, Deliang; Li, Zhenhua; Hu, Shiqi; Huang, Ke; Su, Teng; Liang, Hongxia; Liu, Feiran; Cheng, Ke (NANO LETTERS, 2019)
Keywords: Myocardium infarction; platelets; endogenous stem cells; antibodies

Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells - Huang, Ke; Li, Zhenhua; Su, Teng; Shen, Deliang; Hu, Shiqi; Cheng, Ke (ADVANCED THERAPEUTICS, 2019)
Keywords: bispecific antibodies; immunotherapy; myocardial infarction; stem cells

Cell and biomaterial-based approaches to uterus regeneration - Liu, Feiran; Hu, Shiqi; Wang, Shaowei; Cheng, Ke (REGENERATIVE BIOMATERIALS, 2019)
Keywords: Asherman's syndrome; intrauterine adhesions; endometrium; stem cells

Chemical Engineering of Cell Therapy for Heart Diseases - Li, Zhenhua; Hu, Shiqi; Cheng, Ke (ACCOUNTS OF CHEMICAL RESEARCH, 2019)

Excipient-free nanodispersion of 7-ethyl-10-hydroxycamptothecin exerts potent therapeutic effects against pancreatic cancer cell lines and patient-derived xenografts - Zhang, Linshi; Zhou, Jiarong; Yan, Yingcai; Zhou, Xiaohu; Zhou, Quan; Du, Rong; Hu, Shiqi; Ge, Wenhao; Huang, Yu; Xu, Hao; Kong, Yang; Zheng, Huilin; et al. (CANCER LETTERS, 2019)
Keywords: Excipient-free nanodispersion; Pancreatic cancer; 7-Ethyl-10-hydroxycamptothecin (SN-38); Patient-derived xenograft (PDX); Irinotecan (CPT-11)

Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell-Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome - Liu, Feiran; Hu, Shiqi; Yang, Hua; Li, Zhenhua; Huang, Ke; Su, Teng; Wang, Shaowei; Cheng, Ke (ADVANCED HEALTHCARE MATERIALS, 2019)
Keywords: Asherman's syndrome; endometrial injury; hyaluronic acid; mesenchymal stem cells; secretome

Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging - Hu, Shiqi; Li, Zhenhua; Cores, Jhon; Huang, Ke; Su, Teng; Dinh, Phuong-Uyen; Cheng, Ke (ACS NANO, 2019)
Keywords: needle free injection; dermal fibroblasts; spheroids; exosomes; skin aging; microRNA

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury - Su, Teng; Huang, Ke; Ma, Hong; Liang, Hongxia; Dinh, Phuong-Uyen; Chen, Justin; Shen, Deliang; Allen, Tyler A.; Qiao, Li; Li, Zhenhua; Hu, Shiqi; Cores, Jhon; et al. (ADVANCED FUNCTIONAL MATERIALS, 2019)
Keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome

microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential - Qiao, Li; Hu, Shiqi; Liu, Suyun; Zhang, Hui; Ma, Hong; Huang, Ke; Li, Zhenhua; Su, Teng; Vandergrif, Adam; Tang, Junnan; Allen, Tyler; Dinh, Phuong-Uyen; et al. (JOURNAL OF CLINICAL INVESTIGATION, 2019)

A New Era of Cardiac Cell Therapy: Opportunities and Challenges - Huang, Ke; Hu, Shiqi; Cheng, Ke (Advanced Healthcare Materials, 2018)
Keywords: cardiac patches; cell therapy; exosomes; injury targeting; microRNA; myocardial infarction; synthetic stem cells

Body builder: from synthetic cells to engineered tissues - Hu, Shiqi; Ogle, Brenda M.; Cheng, Ke (CURRENT OPINION IN CELL BIOLOGY, 2018)

Platelets and their biomimetics for regenerative medicine and cancer therapies - Li, Zhenhua; Hu, Shiqi; Cheng, Ke (JOURNAL OF MATERIALS CHEMISTRY B, 2018)

Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair - Li, Zhenhua; Shen, Deliang; Hu, Shiqi; Su, Teng; Huang, Ke; Liu, Feiran; Hou, Lei; Cheng, Ke (ACS NANO, 2018)
Keywords: pretargeting; bioorthogonal click chemistry; heart repair; endogenous stem cells; engineered antibodies

Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide - Vandergriff, Adam; Huang, Ke; Shen, Deliang; Hu, Shiqi; Hensley, Michael Taylor; Caranasos, Thomas G.; Qian, Li; Cheng, Ke (THERANOSTICS, 2018)
Keywords: Targeting; exosomes; cardiac regeneration; heart disease; myocardial infarction