Shiqi Hu

Liu, S., Popowski, K. D., Eckhardt, C. M., Zhang, W., Li, J., Jing, Y., … Cheng, K. (2025, March 22). Inhalable Hsa‐miR‐30a‐3p Liposomes Attenuate Pulmonary Fibrosis. Advanced Science. https://doi.org/10.1002/advs.202405434

Hu, S., Li, Z., Zhu, D., Liu, S., Xing, M., & Cheng, K. (2025, August 5). Microneedle Delivery of Small Extracellular Vesicles From Young Blood to Treat Endothelial Senescence. Advanced Materials. https://doi.org/10.1002/adma.202418352

Mei, X., Zhu, D., Li, J., Huang, K., Hu, S., Xing, M., & Cheng, K. (2025, March 24). Minimally invasive snakebite inspired microneedle delivery system for internal organs. Bioactive Materials, Vol. 49, pp. 576–585. https://doi.org/10.1016/j.bioactmat.2025.03.004

Liu, M., Hu, S., Yan, N., Popowski, K. D., & Cheng, K. (2024, January 11). Inhalable extracellular vesicle delivery of IL-12 mRNA to treat lung cancer and promote systemic immunity. Nature Nanotechnology, Vol. 1. https://doi.org/10.1038/s41565-023-01580-3

Wang, Z., Hu, S., Popowski, K. D., Liu, S., Zhu, D., Mei, X., … Cheng, K. (2024, March 12). Inhalation of ACE2-expressing lung exosomes provides prophylactic protection against SARS-CoV-2. Nature Communications, Vol. 15. https://doi.org/10.1038/s41467-024-45628-x

Koo, D., Cheng, X., Udani, S., Baghdasarian, S., Zhu, D., Li, J., … Carlo, D. D. (2024, June 7). Optimizing cell therapy by sorting cells with high extracellular vesicle secretion. Nature Communications. https://doi.org/10.1038/s41467-024-49123-1

Kilgore, R. E., Moore, B. D., Sripada, S. A., Chu, W., Shastry, S., Barbieri, E., … Menegatti, S. (2024, August 4). Peptide ligands for the universal purification of exosomes by affinity chromatography. Biotechnology and Bioengineering, Vol. 8. https://doi.org/10.1002/bit.28821

Wang, Z., Li, Z., Shi, W., Zhu, D., Hu, S., Dinh, P.-U. C., & Cheng, K. (2023, June 23). A SARS-CoV-2 and influenza double hit vaccine based on RBD-conjugated inactivated influenza A virus. Science Advances, Vol. 9. https://doi.org/10.1126/sciadv.abo4100

Mei, X., Li, J., Wang, Z., Zhu, D., Huang, K., Hu, S., … Cheng, K. (2023). An inhaled bioadhesive hydrogel to shield non-human primates from SARS-CoV-2 infection. Nature Materials, 2. https://doi.org/10.1038/s41563-023-01475-7

Wang, X., Hu, S., Zhu, D., Li, J., Cheng, K., & Liu, G. (2023, February 28). Comparison of extruded cell nanovesicles and exosomes in their molecular cargos and regenerative potentials. Nano Research, Vol. 16, pp. 7248–7259. https://doi.org/10.1007/s12274-023-5374-3

Cheng, X., Hu, S., & Cheng, K. (2023, June 9). Microneedle Patch Delivery of PROTACs for Anti-Cancer Therapy. ACS Nano, Vol. 6. https://doi.org/10.1021/acsnano.3c03166

Hu, S., Zhu, D., Li, Z., & Cheng, K. (2022, September 23). Detachable Microneedle Patches Deliver Mesenchymal Stromal Cell Factor-Loaded Nanoparticles for Cardiac Repair. ACS Nano, Vol. 9. https://doi.org/10.1021/acsnano.2c03060

Zhu, D., Liu, S., Huang, K., Wang, Z., Hu, S., Li, J., … Cheng, K. (2022, October 13). Intrapericardial Exosome Therapy Dampens Cardiac Injury via Activating Foxo3. Circulation Research, Vol. 10, pp. E135–E150. https://doi.org/10.1161/CIRCRESAHA.122.321384

Yao, J., Huang, K., Zhu, D., Chen, T., Jiang, Y., Zhang, J., … Cheng, K. (2021, June 21). A Minimally Invasive Exosome Spray Repairs Heart after Myocardial Infarction. ACS Nano, Vol. 7, pp. 11099–11111. https://doi.org/10.1021/acsnano.1c00628

Mei, X., Zhu, D., Li, J., Huang, K., Hu, S., Li, Z., … Cheng, K. (2021, November 1). A fluid-powered refillable origami heart pouch for minimally invasive delivery of cell therapies in rats and pigs. Med, Vol. 11, pp. 1253–1268.e4. https://doi.org/10.1016/j.medj.2021.10.001

Zhang, S., Zhu, D., Li, Z., Huang, K., Hu, S., Lutz, H., … Cheng, K. (2021, January 1). A stem cell-derived ovarian regenerative patch restores ovarian function and rescues fertility in rats with primary ovarian insufficiency. Theranostics, Vol. 11, pp. 8894–8908. https://doi.org/10.7150/thno.61690

Li, J., Hu, S., Zhu, D., Huang, K., Mei, X., Juan Abad, B. L., & Cheng, K. (2021, April 20). All Roads Lead to Rome (the Heart): Cell Retention and Outcomes From Various Delivery Routes of Cell Therapy Products to the Heart. Journal of the American Heart Association, Vol. 10. https://doi.org/10.1161/JAHA.120.020402

Hu, S., Li, Z., Shen, D., Zhu, D., Huang, K., Su, T., … Cheng, K. (2021, April 5). Exosome-eluting stents for vascular healing after ischaemic injury. Nature Biomedical Engineering, Vol. 4, pp. 1174–1188. https://doi.org/10.1038/s41551-021-00705-0

Wang, X., Hu, S., Li, J., Zhu, D., Wang, Z., Cores, J., … Huang, K. (2021, November 18). Extruded Mesenchymal Stem Cell Nanovesicles Are Equally Potent to Natural Extracellular Vesicles in Cardiac Repair. ACS Applied Materials & Interfaces, Vol. 12, pp. 55767–55779. https://doi.org/10.1021/acsami.1c08044

Li, Z., Zhu, D., Hui, Q., Bi, J., Yu, B., Huang, Z., … Wang, X. (2021, February 4). Injection of ROS‐Responsive Hydrogel Loaded with Basic Fibroblast Growth Factor into the Pericardial Cavity for Heart Repair. Advanced Functional Materials, Vol. 31. https://doi.org/10.1002/adfm.202004377

Li, J., Lv, Y., Zhu, D., Mei, X., Huang, K., Wang, X., … Wang, J. (2021, August 10). Intrapericardial hydrogel injection generates high cell retention and augments therapeutic effects of mesenchymal stem cells in myocardial infarction. Chemical Engineering Journal, Vol. 1, p. 131581. https://doi.org/10.1016/j.cej.2021.131581

Hu, S., Wang, X., Li, Z., Zhu, D., Cores, J., Wang, Z., … Cheng, K. (2021, June 8). Platelet membrane and stem cell exosome hybrids enhance cellular uptake and targeting to heart injury. Nano Today, Vol. 8. https://doi.org/10.1016/j.nantod.2021.101210

Su, T., Huang, K., Mathews, K. G., Scharf, V. F., Hu, S., Li, Z., … Cheng, K. (2020, October 5). Cardiac Stromal Cell Patch Integrated with Engineered Microvessels Improves Recovery from Myocardial Infarction in Rats and Pigs. ACS Biomaterials Science & Engineering, Vol. 6, pp. 6309–6320. https://doi.org/10.1021/acsbiomaterials.0c00942

Hu, S., Li, Z., Lutz, H., Huang, K., Su, T., Cores, J., … Cheng, K. (2020, July 24). Dermal exosomes containing miR-218-5p promote hair regeneration by regulating β-catenin signaling. Science Advances, Vol. 6. https://doi.org/10.1126/sciadv.aba1685

Li, J., Hu, S., & Cheng, K. (2020, April 1). Engineering better stem cell therapies for treating heart diseases. Annals of Translational Medicine, Vol. 8. https://doi.org/10.21037/atm.2020.03.44

Popowski, K., Lutz, H., Hu, S., George, A., Dinh, P. U., & Cheng, K. (2020, June 29). Exosome therapeutics for lung regenerative medicine. Journal of Extracellular Vesicles, Vol. 9, p. 1785161. https://doi.org/10.1080/20013078.2020.1785161

Hu, S., Qiao, L., & Cheng, K. (2020, August 28). Generation and Manipulation of Exosomes. Methods in Molecular Biology. https://doi.org/10.1007/978-1-0716-0668-1_22

Dinh, P.-U. C., Paudel, D., Brochu, H., Popowski, K. D., Gracieux, M. C., Cores, J., … Cheng, K. (2020, February 28). Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis. Nature Communications, Vol. 11. https://doi.org/10.1038/s41467-020-14344-7

Liang, H., Li, Z., Ren, Z., Jia, Q., Guo, L., Li, S., … Cheng, K. (2020, June 13). Light-triggered NO-releasing nanoparticles for treating mice with liver fibrosis. Nano Research, Vol. 13, pp. 2197–2202. https://doi.org/10.1007/s12274-020-2833-6

Zheng, P., Fan, M., Liu, H., Zhang, Y., Dai, X., Li, H., … Li, Z. (2020, November 25). Self-Propelled and Near-Infrared-Phototaxic Photosynthetic Bacteria as Photothermal Agents for Hypoxia-Targeted Cancer Therapy. ACS Nano, Vol. 15, pp. 1100–1110. https://doi.org/10.1021/acsnano.0c08068

Li, Z., Hu, S., Huang, K., Su, T., Cores, J., & Cheng, K. (2020, February 6). Targeted anti–IL-1β platelet microparticles for cardiac detoxing and repair. Science Advances, Vol. 6. https://doi.org/10.1126/sciadv.aay0589

Qiao, L., Hu, S., Huang, K., Su, T., Li, Z., Vandergriff, A., … Cheng, K. (2020, January 1). Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs. Theranostics, Vol. 10, pp. 3474–3487. https://doi.org/10.7150/thno.39434

Shen, D., Li, Z., Hu, S., Huang, K., Su, T., Liang, H., … Cheng, K. (2019, February 18). Antibody-Armed Platelets for the Regenerative Targeting of Endogenous Stem Cells. Nano Letters, Vol. 19, pp. 1883–1891. https://doi.org/10.1021/acs.nanolett.8b04970

Huang, K., Li, Z., Su, T., Shen, D., Hu, S., & Cheng, K. (2019, May 31). Bispecific Antibody Therapy for Effective Cardiac Repair through Redirection of Endogenous Stem Cells. Advanced Therapeutics, Vol. 2. https://doi.org/10.1002/adtp.201900009

Liu, F., Hu, S., Wang, S., & Cheng, K. (2019, April 26). Cell and biomaterial-based approaches to uterus regeneration. Regenerative Biomaterials, Vol. 6, pp. 141–148. https://doi.org/10.1093/rb/rbz021

Li, Z., Hu, S., & Cheng, K. (2019, May 24). Chemical Engineering of Cell Therapy for Heart Diseases. Accounts of Chemical Research, Vol. 52, pp. 1687–1696. https://doi.org/10.1021/acs.accounts.9b00137

Zhang, L., Zhou, J., Yan, Y., Zhou, X., Zhou, Q., Du, R., … Wang, W. (2019, August 31). Excipient-free nanodispersion of 7-ethyl-10-hydroxycamptothecin exerts potent therapeutic effects against pancreatic cancer cell lines and patient-derived xenografts. Cancer Letters, Vol. 465, pp. 36–44. https://doi.org/10.1016/j.canlet.2019.08.019

Liu, F., Hu, S., Yang, H., Li, Z., Huang, K., Su, T., … Cheng, K. (2019, May 30). Hyaluronic Acid Hydrogel Integrated with Mesenchymal Stem Cell‐Secretome to Treat Endometrial Injury in a Rat Model of Asherman's Syndrome. Advanced Healthcare Materials, Vol. 8. https://doi.org/10.1002/adhm.201900411

Hu, S., Li, Z., Cores, J., Huang, K., Su, T., Dinh, P.-U., & Cheng, K. (2019, August 26). Needle-Free Injection of Exosomes Derived from Human Dermal Fibroblast Spheroids Ameliorates Skin Photoaging. ACS Nano, Vol. 13, pp. 11273–11282. https://doi.org/10.1021/acsnano.9b04384

Qiao, L., Hu, S., Liu, S., Zhang, H., Ma, H., Huang, K., … Cheng, K. (2019, April 28). microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential. Journal of Clinical Investigation, Vol. 129, pp. 2237–2250. https://doi.org/10.1172/JCI123135

Huang, K., Hu, S., & Cheng, K. (2018). A New Era of Cardiac Cell Therapy: Opportunities and Challenges. Advanced Healthcare Materials, 8(2), 1801011. https://doi.org/10.1002/adhm.201801011

Hu, S., Ogle, B. M., & Cheng, K. (2018, April 25). Body builder: from synthetic cells to engineered tissues. Current Opinion in Cell Biology, Vol. 54, pp. 37–42. https://doi.org/10.1016/j.ceb.2018.04.010

Li, Z., Hu, S., & Cheng, K. (2018, January 1). Platelets and their biomimetics for regenerative medicine and cancer therapies. Journal of Materials Chemistry B, Vol. 6, pp. 7354–7365. https://doi.org/10.1039/c8tb02301h

Su, T., Huang, K., Ma, H., Liang, H., Dinh, P. U., Chen, J., … Cheng, K. (2018, November 13). Platelet‐Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury. Advanced Functional Materials, Vol. 29. https://doi.org/10.1002/adfm.201803567

Li, Z., Shen, D., Hu, S., Su, T., Huang, K., Liu, F., … Cheng, K. (2018, December 4). Pretargeting and Bioorthogonal Click Chemistry-Mediated Endogenous Stem Cell Homing for Heart Repair. ACS Nano, Vol. 12, pp. 12193–12200. https://doi.org/10.1021/acsnano.8b05892

Vandergriff, A., Huang, K., Shen, D., Hu, S., Hensley, M. T., Caranasos, T. G., … Cheng, K. (2018, January 1). Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide. Theranostics, Vol. 8, pp. 1869–1878. https://doi.org/10.7150/thno.20524