S. Hunter Walker

Works (9)

Updated: July 6th, 2023 21:17

2015 article

Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples

Hecht, E. S., Scholl, E. H., Walker, S. H., Taylor, A. D., Cliby, W. A., Motsinger-Reif, A. A., & Muddiman, D. C. (2015, September 8). Journal of Proteome Research, Vol. 14, pp. 4394–4401.

By: E. Hecht*, E. Scholl*, S. Walker*, A. Taylor, W. Cliby *, A. Motsinger-Reif*, D. Muddiman* 

author keywords: N-linked glycosylation; INLIGHT; ovarian cancer; relative quantification; cancer biomarker; human plasma
MeSH headings : Biomarkers, Tumor / blood; Carbohydrate Sequence; Case-Control Studies; Chromatography, Liquid / methods; Female; Fucose / blood; Glycosylation; Humans; Hydrazines / chemistry; Molecular Sequence Data; Neoplasm Staging; Ovarian Neoplasms / blood; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Polysaccharides / blood; Sialic Acids / blood; Staining and Labeling / methods; Tandem Mass Spectrometry / methods
topics (OpenAlex): Glycosylation and Glycoproteins Research; Monoclonal and Polyclonal Antibodies Research; Lung Cancer Research Studies
TL;DR: For all N-glycans, the vectors of the effects from stages II-IV were sequentially reversed, suggesting potential biological changes in OVC morphology or in host response. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

Individuality Normalization when Labeling with Isotopic Glycan Hydrazide Tags (INLIGHT): A Novel Glycan-Relative Quantification Strategy

Walker, S. H., Taylor, A. D., & Muddiman, D. C. (2013, July 15). Journal of the American Society for Mass Spectrometry, Vol. 24, pp. 1376–1384.

By: S. Walker n, A. Taylor n & D. Muddiman n 

author keywords: Glycomics; Hydrazide Reagents; Stable Isotope Labeling; Normalization; Hydrazone; Formation; Relative Quantification; N-Linked Glycans
MeSH headings : Chromatography, Reverse-Phase; Glycomics / methods; Glycoproteins / chemistry; Glycosylation; Humans; Isotope Labeling / methods; Mass Spectrometry / methods; Plasma / chemistry; Polysaccharides / analysis; Polysaccharides / isolation & purification
topics (OpenAlex): Glycosylation and Glycoproteins Research; Advanced Proteomics Techniques and Applications; Enzyme Structure and Function
TL;DR: The ability to spike in a glycoprotein and detect change at the glycan level validates both the sample preparation and data analysis strategy, making INLIGHT an invaluable relative quantification strategy for the field of glycomics. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 article

The use of a xylosylated plant glycoprotein as an internal standard accounting for N‐linked glycan cleavage and sample preparation variability

Walker, S. H., Taylor, A. D., & Muddiman, D. C. (2013, May 7). Rapid Communications in Mass Spectrometry, Vol. 27, pp. 1354–1358.

By: S. Walker n, A. Taylor n & D. Muddiman n 

MeSH headings : Analytic Sample Preparation Methods / standards; Glycoproteins / chemistry; Glycosylation; Mass Spectrometry / standards; Plant Proteins / chemistry; Polysaccharides / chemistry; Protein Processing, Post-Translational; Reference Standards
topics (OpenAlex): Glycosylation and Glycoproteins Research; Proteoglycans and glycosaminoglycans research; Genomics and Phylogenetic Studies
TL;DR: The inclusion of two internal standards, maltoheptaose and horseradish peroxidase (HRP), is studied to demonstrate the effectiveness of using a glycoprotein as an internal standard in glycan relative quantification experiments. (via Semantic Scholar)
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Sources: NC State University Libraries, NC State University Libraries
Added: August 6, 2018

2012 article

Evidence for Complex Molecular Architectures for Solvent-Extracted Lignins

Harton, S. E., Pingali, S. V., Nunnery, G. A., Baker, D. A., Walker, S. H., Muddiman, D. C., … Langan, P. (2012, April 17). ACS Macro Letters, Vol. 1, pp. 568–573.

By: S. Harton, S. Pingali, G. Nunnery, D. Baker*, S. Walker n, D. Muddiman n , T. Koga *, T. Rials *, V. Urban, P. Langan

topics (OpenAlex): Lignin and Wood Chemistry; Fermentation and Sensory Analysis; Biofuel production and bioconversion
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 article

Systematic Comparison of Reverse Phase and Hydrophilic Interaction Liquid Chromatography Platforms for the Analysis of N-Linked Glycans

Walker, S. H., Carlisle, B. C., & Muddiman, D. C. (2012, September 6). Analytical Chemistry, Vol. 84, pp. 8198–8206.

By: S. Walker n, B. Carlisle n & D. Muddiman n 

MeSH headings : Chromatography, Reverse-Phase; Hydrophobic and Hydrophilic Interactions; Mass Spectrometry; Polysaccharides / analysis
topics (OpenAlex): Glycosylation and Glycoproteins Research; Analytical Chemistry and Chromatography; Chromatography in Natural Products
TL;DR: The data presented show that separation of derivatized N-linked glycans by reverse phase chromatography significantly out-performs traditional separation of native or derivatization glycansBy hydrophilic interaction chromatography. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 article

Hydrophobic Derivatization of N-linked Glycans for Increased Ion Abundance in Electrospray Ionization Mass Spectrometry

Walker, S. H., Lilley, L. M., Enamorado, M. F., Comins, D. L., & Muddiman, D. C. (2011, May 2). Journal of the American Society for Mass Spectrometry, Vol. 22, pp. 1309–1317.

By: S. Walker n, L. Lilley *, M. Enamorado n, D. Comins n & D. Muddiman n 

author keywords: Hydrophobic Derivatization; HILIC; nanoESI; N-Linked Glycans; Hydrazone Formation
MeSH headings : Blood Proteins / chemistry; Carbohydrate Sequence; Chromatography, Liquid; Glycoproteins / chemistry; Humans; Hydrazines / chemistry; Hydrophobic and Hydrophilic Interactions; Polysaccharides / chemistry; Small Molecule Libraries; Spectrometry, Mass, Electrospray Ionization / methods; Tandem Mass Spectrometry
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Glycosylation and Glycoproteins Research
TL;DR: The results of this study will direct the future synthesis of hydrophobic reagents for glycan analysis using the correlation between hydrophobicity and theoretical non-polar surface area calculation to facilitate the development of an optimum tag for gly can derivatization. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 article

Spectral Accuracy and Sulfur Counting Capabilities of the LTQ-FT-ICR and the LTQ-Orbitrap XL for Small Molecule Analysis

Blake, S. L., Walker, S. H., Muddiman, D. C., Hinks, D., & Beck, K. R. (2011, September 20). Journal of the American Society for Mass Spectrometry, Vol. 22, pp. 2269–2275.

By: S. Blake  n, S. Walker n, D. Muddiman n , D. Hinks n & K. Beck n

author keywords: Electrospray ionization; FT-ICR-MS; Orbitrap-MS; Forensic analysis; Textiles; Trace evidence
MeSH headings : Chi-Square Distribution; Coloring Agents / chemistry; Forensic Sciences; Fourier Analysis; Mass Spectrometry / methods; Polyesters / chemistry; Sensitivity and Specificity; Sulfur / analysis; Textiles / analysis
topics (OpenAlex): Isotope Analysis in Ecology; Identification and Quantification in Food; Cultural Heritage Materials Analysis
TL;DR: DY42, a high-volume disperse dye for polyester, was used to compare the capabilities of the LTQ-Orbitrap XL and theLTQ-FT-ICR with respect to mass measurement accuracy (MMA), spectral accuracy, and sulfur counting. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 article

Stable-Isotope Labeled Hydrophobic Hydrazide Reagents for the Relative Quantification of N-Linked Glycans by Electrospray Ionization Mass Spectrometry

Walker, S. H., Budhathoki-Uprety, J., Novak, B. M., & Muddiman, D. C. (2011, July 20). Analytical Chemistry, Vol. 83, pp. 6738–6745.

By: S. Walker n, J. Budhathoki-Uprety n , B. Novak n & D. Muddiman n 

MeSH headings : Carbon Isotopes / chemistry; Glycopeptides / analysis; Glycosylation; Hydrazones / chemistry; Hydrophobic and Hydrophilic Interactions; Isotope Labeling; Polysaccharides / analysis; Spectrometry, Mass, Electrospray Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Glycosylation and Glycoproteins Research; Advanced Proteomics Techniques and Applications
TL;DR: It is shown that these reagents are capable of quantifying changes in glycosylation in simple mixtures, and the analytical variability of the reagents in pooled plasma samples is shown to be less than ±30%. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2010 article

Interplay of Permanent Charge and Hydrophobicity in the Electrospray Ionization of Glycans

Walker, S. H., Papas, B. N., Comins, D. L., & Muddiman, D. C. (2010, June 30). Analytical Chemistry, Vol. 82, pp. 6636–6642.

By: S. Walker n, B. Papas n, D. Comins n & D. Muddiman n 

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Microfluidic and Capillary Electrophoresis Applications
TL;DR: The effectiveness of the incorporation of a permanent charge is studied and determined to hamper glycan analysis and a procedure for glycan hydrazone formation is optimized and outlined where a large number of variables were simultaneously analyzed using a fractional factorial design (FFD). (via Semantic Scholar)
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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