Sarah Josephine O'Flaherty

Works (31)

Updated: October 22nd, 2025 05:07

2025 article

Differential modulation of post-antibiotic colonization resistance to Clostridioides difficile by two probiotic Lactobacillus strains

Foley, M. H., McMillan, A. S., O'Flaherty, S., Thanissery, R., Vanhoy, M. E., Fuller, M. G., … Theriot, C. M. (2025, July 21). (J. Ravel, Ed.). MBio, Vol. 7.

By: M. Foley n, A. McMillan  n, S. O'Flaherty n, R. Thanissery  n, M. Vanhoy n, M. Fuller n, R. Barrangou n , C. Theriot n

Ed(s): J. Ravel

author keywords: microbiome; <italic>Lactobacillus</italic>; probiotic; <italic>Clostridioides difficile</italic>; colonization resistance; <italic>Muribaculaceae</italic>
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Probiotics and Fermented Foods
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 28, 2025

2025 article

Recombinant Lactococcus lactis-based oral vaccine expressing non-toxic alpha toxin domains of Clostridium septicum can offer protection against Clostridial dermatitis in turkeys

John, F. A., Criollo, V., Gaghan, C., Armwood, A. R., Boodhoo, N., Thachil, A. J., … Kulkarni, R. R. (2025, October 1). Vaccine, Vol. 65.

By: F. John n, V. Criollo n, C. Gaghan n, A. Armwood n , N. Boodhoo *, A. Thachil*, S. O'Flaherty n, R. Kulkarni n 

author keywords: Clostridial dermatitis; Gangrenous dermatitis; Turkey; Alpha-toxin; Vaccine; Immunity
MeSH headings : Animals; Turkeys / immunology; Poultry Diseases / prevention & control; Poultry Diseases / immunology; Poultry Diseases / microbiology; Clostridium Infections / prevention & control; Clostridium Infections / veterinary; Clostridium Infections / immunology; Bacterial Vaccines / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Lactococcus lactis / genetics; Bacterial Toxins / immunology; Bacterial Toxins / genetics; Administration, Oral; Clostridium septicum / immunology; Clostridium septicum / genetics; Vaccines, Synthetic / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / genetics; Antibodies, Bacterial / blood; Dermatitis / prevention & control; Dermatitis / veterinary; Dermatitis / immunology; Cytokines; Vaccination
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Toxin Mechanisms and Immunotoxins; Streptococcal Infections and Treatments
Sources: Web Of Science, NC State University Libraries
Added: October 21, 2025

2025 article

The curated Lactobacillus acidophilus NCFM genome provides insights into strain specificity and microevolution

Pan, M., Sarah, O. F., Hibberd, A., Gerdes, S., Morovic, W., & Barrangou, R. (2025, January 3). BMC Genomics, Vol. 26.

By: M. Pan  n, O. Sarah n, A. Hibberd, S. Gerdes, W. Morovic & R. Barrangou n 

author keywords: <italic>Lactobacillus acidophilus</italic> NCFM; Probiotic; Comparative genomics; Pan genome; Strain variation; Genome; Single nucleotide polymorphism
MeSH headings : Lactobacillus acidophilus / genetics; Genome, Bacterial; Evolution, Molecular; Phylogeny; Species Specificity; Genomics / methods; Polymorphism, Single Nucleotide; Genomic Instability
topics (OpenAlex): Probiotics and Fermented Foods; Genomics and Phylogenetic Studies; Bacteriophages and microbial interactions
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2023 article

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., Sarah, O. F., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). Nature Microbiology, Vol. 3.

By: M. Foley n, M. Walker *, A. Stewart n, O. Sarah n, E. Gentry *, S. Patel *, V. Beaty *, G. Allen n ...

MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gut microbiota and health; Helicobacter pylori-related gastroenterology studies
TL;DR: Insight is provided into the structural basis of BSH mechanisms that shape the BA landscape and promote colonization resistance against C. difficile in vitro and in pre-clinical in vivo models of CDI. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

2023 article

Impact of Pomegranate on Probiotic Growth, Viability, Transcriptome and Metabolism

Sarah, O. F., Cobian, N., & Barrangou, R. (2023, February 5). Microorganisms, Vol. 11.

By: O. Sarah n, N. Cobian n & R. Barrangou n 

author keywords: probiotic; prebiotic; pomegranate; lactobacilli; transcriptomic
topics (OpenAlex): Pomegranate: compositions and health benefits; Essential Oils and Antimicrobial Activity; Plant Pathogenic Bacteria Studies
TL;DR: The results show that POM extract triggers species-specific responses by probiotic strains and substantiates the rising interest in using POM as a prebiotic compound. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 7, 2023

2023 article

Lactobacillus acidophilus Expressing Murine Rotavirus VP8 and Mucosal Adjuvants Induce Virus-Specific Immune Responses

Gilfillan, D., Vilander, A. C., Pan, M., Goh, Y. J., Sarah, O. F., Feng, N., … Dean, G. A. (2023, November 28). Vaccines, Vol. 11.

By: D. Gilfillan*, A. Vilander*, M. Pan  n, Y. Goh n, O. Sarah n, N. Feng *, B. Fox *, C. Lang* ...

author keywords: rotavirus; Lactobacillus acidophilus; next-generation vaccine
topics (OpenAlex): Viral gastroenteritis research and epidemiology; Animal Virus Infections Studies; Viral Infections and Immunology Research
TL;DR: It is indicated that novel rLA constructs expressing VP8 can be successfully constructed and used to generate modest homotypic protection from rotavirus challenge in an adult murine model, indicating the potential for a probiotic next-generation vaccine construct against human rotav virus. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
1. No Poverty (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 1, 2024

2022 article

Metabolomic Analysis of Lactobacillus acidophilus, L. gasseri, L. crispatus, and Lacticaseibacillus rhamnosus Strains in the Presence of Pomegranate Extract

Chamberlain, M. C., O'Flaherty, S., Cobián, N., & Barrangou, R. (2022, May 18). Frontiers in Microbiology, Vol. 5.

By: M. Chamberlain  n, S. O'Flaherty n, N. Cobián n & R. Barrangou n 

author keywords: metabolomics; Lactobacillus; probiotic; pomegranate extract; prebiotic
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Food Science and Nutritional Studies
TL;DR: The growth of the strains with and without the presence of POM were investigated and their carbohydrate utilization and enzyme activity profiles were identified and an untargeted metabolomic approach was utilized to quantitatively and qualitatively define the metabolite profiles of these strains. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 13, 2022

2021 article

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization

Foley, M. H., Sarah, O. F., Allen, G., Rivera, A. J., Stewart, A. K., Barrangou, R., & Theriot, C. M. (2021, February 1). Proceedings of the National Academy of Sciences, Vol. 118.

By: M. Foley n, O. Sarah n, G. Allen n, A. Rivera n, A. Stewart n, R. Barrangou n , C. Theriot n

author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
topics (OpenAlex): Gut microbiota and health; Drug Transport and Resistance Mechanisms; Probiotics and Fermented Foods
TL;DR: It is shown that BA type and BSH substrate preferences affect in vitro and in vivo growth of both species and that BSH enzymatic preferences and the intrinsic chemical features of various BAs determine the toxicity of these molecules during Lactobacillus growth. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2021

2020 article

Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface

Klotz, C., Goh, Y. J., Sarah, O. F., Johnson, B., & Barrangou, R. (2020, March 17). Frontiers in Microbiology, Vol. 11.

By: C. Klotz n, Y. Goh n, O. Sarah n, B. Johnson n & R. Barrangou n 

author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: Identification of similar proteins in alternative bacterial species may help pinpoint next-generation host-adapted probiotic candidates. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2019 article

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract

Foley, M. H., Sarah, O. F., Barrangou, R., & Theriot, C. M. (2019, March 7). (L. J. Knoll, Ed.). PLoS Pathogens, Vol. 15.

By: M. Foley n, O. Sarah n, R. Barrangou n  & C. Theriot n

Ed(s): L. Knoll

MeSH headings : Amidohydrolases / metabolism; Amidohydrolases / physiology; Bile Acids and Salts / metabolism; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract; Host Microbial Interactions / physiology; Humans
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Pediatric Hepatobiliary Diseases and Treatments; Antibiotic Resistance in Bacteria
TL;DR: Bile acids serve as substrates for bile acid receptors (BARs) found throughout the body that control critical regulatory and metabolic processes and therefore represent an important class of bioactive molecules, and there remain gaps in knowledge about the bacterial enzymes driving their composition and modification. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: April 15, 2019

2018 article

The Lactobacillus Bile Salt Hydrolase Repertoire Reveals Niche-Specific Adaptation

Sarah, O. F., Crawley, A. B., Theriot, C. M., & Barrangou, R. (2018, May 29). (C. D. Ellermeier, Ed.). MSphere, Vol. 3.

By: O. Sarah n, A. Crawley n, C. Theriot n & R. Barrangou n 

Ed(s): C. Ellermeier

author keywords: Lactobacillus; bile acid; bile salt hydrolase; gastrointestinal tract; niche; penicillin V acylase; probiotic; therapeutic
MeSH headings : Adaptation, Biological; Amidohydrolases / genetics; Genetic Variation; Genotype; Lactobacillus / classification; Lactobacillus / enzymology; Lactobacillus / genetics; Penicillin Amidase / genetics; Phylogeny; Sequence Homology
topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Biochemical Analysis and Sensing Techniques
TL;DR: The BSH repertoire across 170 sequenced species revealed that BSH-encoding lactobacilli primarily adopt the vertebrate-adapted lifestyle but not the environmental or plant-associated subsets, and will guide future mechanistic studies of BSH activity and contribute to the development and selection of Lactobacillus strains with therapeutic potential. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

CRISPR-based engineering of next-generation lactic acid bacteria

Hidalgo-Cantabrana, C., Sarah, O. F., & Barrangou, R. (2017, June 1). Current Opinion in Microbiology, Vol. 37, pp. 79–87.

By: C. Hidalgo-Cantabrana n, O. Sarah n & R. Barrangou n 

MeSH headings : Bifidobacterium / genetics; Bifidobacterium / physiology; CRISPR-Cas Systems; Food Microbiology / methods; Gene Editing; Humans; Lactobacillus / genetics; Lactobacillus / physiology; Metabolic Engineering; Probiotics
topics (OpenAlex): CRISPR and Genetic Engineering; Transgenic Plants and Applications; Microbial Metabolic Engineering and Bioproduction
TL;DR: The advent of CRISPR-based technologies has opened new avenues for the development of next-generation food microorganisms and probiotics with enhanced functionalities and can be harnessed to genetically modify probiotics and enhance their therapeutic potential to deliver vaccines or modulate the host immune response. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus

Selle, K., Goh, Y. J., Johnson, B. R., Sarah, O. F., Andersen, J. M., Barrangou, R., & Klaenhammer, T. R. (2017, April 11). Frontiers in Microbiology, Vol. 8.

By: K. Selle n, Y. Goh n, B. Johnson n, O. Sarah n, J. Andersen n, R. Barrangou n , T. Klaenhammer n

topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Bacterial Genetics and Biotechnology
TL;DR: Results elucidate the impact of ltaS deletion on the transcriptome and extracellular proteins of L. acidophilus, suggesting roles of LTA in cell morphology and ion homeostasis as a structural component of the Gram positive cell wall. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

Investigating the Effect of Growth Phase on the Surface-Layer Associated Proteome of Lactobacillus acidophilus Using Quantitative Proteomics

Klotz, C., O'Flaherty, S., Goh, Y. J., & Barrangou, R. (2017, November 7). Frontiers in Microbiology, Vol. 8.

By: C. Klotz n, S. O'Flaherty n, Y. Goh n & R. Barrangou n 

author keywords: Lactobacillus; probiotic; cell surface; S-layer; quantitative proteomics
topics (OpenAlex): Probiotics and Fermented Foods; Bacteriophages and microbial interactions; Genomics and Phylogenetic Studies; Advanced Proteomics Techniques and Applications; Glycosylation and Glycoproteins Research
TL;DR: This study establishes a framework for quantifying condition-dependent changes to cell surface proteins that can easily be applied to other S-layer forming bacteria. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM

Johnson, B. R., Sarah, O. F., Goh, Y. J., Carroll, I., Barrangou, R., & Klaenhammer, T. R. (2017, June 30). Frontiers in Microbiology, Vol. 8.

By: B. Johnson n, O. Sarah n, Y. Goh n, I. Carroll *, R. Barrangou n  & T. Klaenhammer n

author keywords: serine protease; S-layer; S-layer associated proteins; Lactobacillus; probiotic; intestinal barrier integrity; mucin; fibronectin
topics (OpenAlex): Probiotics and Fermented Foods; Antimicrobial Peptides and Activities; Infant Nutrition and Health
TL;DR: The absence of PrtX within the exoproteome of a ΔprtX strain caused morphological changes, resulting in a pleiotropic increase of the organisms’ immunomodulatory properties and interactions with some intestinal epithelial cell components. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose – an emerging prebiotic

Celebioglu, H. U., Ejby, M., Majumder, A., Købler, C., Goh, Y. J., Thorsen, K., … Svensson, B. (2016, March 9). PROTEOMICS.

By: H. Celebioglu *, M. Ejby *, A. Majumder*, C. Købler*, Y. Goh n, K. Thorsen *, B. Schmidt*, S. O'Flaherty n ...

author keywords: Adhesion; HT-29 cells; Moonlighting proteins; Probiotics; Raffinose; Surface and whole cell proteomes
MeSH headings : Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Galactose / metabolism; Gene Expression Regulation, Bacterial; Gene Ontology; Glucosyltransferases / genetics; Glucosyltransferases / metabolism; Glycoside Hydrolases / genetics; Glycoside Hydrolases / metabolism; HT29 Cells; Humans; Lactobacillus acidophilus / drug effects; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Molecular Sequence Annotation; Peptide Elongation Factor G / genetics; Peptide Elongation Factor G / metabolism; Prebiotics; Probiotics / metabolism; Proteome / genetics; Proteome / metabolism; Raffinose / pharmacology; Staining and Labeling; alpha-Galactosidase / genetics; alpha-Galactosidase / metabolism
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Digestive system and related health; Gut microbiota and health
TL;DR: Insight at the molecular and cellular levels contributed to the understanding of the interplay of a synbiotic composed of NCFM and raffinose with the host. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2016 article

Multivalent Chromosomal Expression of the Clostridium botulinum Serotype A Neurotoxin Heavy-Chain Antigen and the Bacillus anthracis Protective Antigen in Lactobacillus acidophilus

O'Flaherty, S., & Klaenhammer, T. R. (2016, August 6). Applied and Environmental Microbiology.

By: S. O'Flaherty n & T. Klaenhammer n

MeSH headings : Anthrax / microbiology; Anthrax / prevention & control; Bacillus anthracis / genetics; Bacillus anthracis / metabolism; Bacterial Vaccines / genetics; Bacterial Vaccines / metabolism; Botulinum Toxins, Type A / genetics; Botulinum Toxins, Type A / metabolism; Botulism / microbiology; Botulism / prevention & control; Chromosomes, Bacterial / genetics; Chromosomes, Bacterial / metabolism; Clostridium botulinum / genetics; Clostridium botulinum / metabolism; Gene Expression; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism
topics (OpenAlex): Bacterial Genetics and Biotechnology; Bacteriophages and microbial interactions; Clostridium difficile and Clostridium perfringens research
TL;DR: It is demonstrated that chromosomal integrative recombinant strains are promising vaccine delivery vehicles when targeted into high-expression chromosomal regions and eliminate the requirement for antibiotic selective maintenance of recombinant plasmids. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 article

Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri

Sanozky-Dawes, R., Selle, K., O'Flaherty, S., Klaenhammer, T., & Barrangou, R. (2015, July 9). Microbiology, Vol. 161, pp. 1752–1761.

By: R. Sanozky-Dawes n, K. Selle n, S. O'Flaherty n, T. Klaenhammer n & R. Barrangou n 

MeSH headings : Base Sequence; CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats; Gene Order; Genome, Bacterial; Lactobacillus / genetics; Molecular Sequence Data; Plasmids / genetics
topics (OpenAlex): CRISPR and Genetic Engineering; Bacteriophages and microbial interactions; Cytomegalovirus and herpesvirus research
TL;DR: The distribution and function of a native type II-A CRISPR-Cas system in the commensal species L. gasseri is reported, which open avenues for applications for bacteriophage protection and genome modification in L.gasseri, and contribute to the fundamental understanding of CRISpr-Cas systems in bacteria. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 article

Lactic acid bacteria to modulate virulence expression in pathogenic bacteria: An alternative to killing ?

Even, S., Bouchard, D., & Loir, Y. L. (2014, January 1). HAL (Le Centre Pour La Communication Scientifique Directe).

By: S. Even, D. Bouchard & Y. Loir

topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Digestive system and related health
Source: NC State University Libraries
Added: August 6, 2018

2014 article

Sortase-deficient lactobacilli: effect on immunomodulation and gut retention

Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & Sarah, O. F. (2014, December 13). Microbiology.

By: E. Call n, Y. Goh n, K. Selle n, T. Klaenhammer n & O. Sarah n

MeSH headings : Aminoacyltransferases / genetics; Aminoacyltransferases / immunology; Aminoacyltransferases / metabolism; Animals; Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Proteins / metabolism; Caco-2 Cells; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / immunology; Cysteine Endopeptidases / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Gastrointestinal Tract / immunology; Gastrointestinal Tract / microbiology; Humans; Immunomodulation; Lactobacillus / enzymology; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / physiology; Mice; Swine; Tumor Necrosis Factor-alpha / immunology
topics (OpenAlex): Biochemical and Structural Characterization; Probiotics and Fermented Foods; Biochemical Analysis and Sensing Techniques
TL;DR: It is shown for the first time that sortase-dependent proteins contribute to gut retention of probiotic microbes in the gastrointestinal tract. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2013 article

Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM

Johnson, B., Selle, K., Sarah, O. F., Goh, Y. J., & Klaenhammer, T. (2013, September 4). Microbiology.

By: B. Johnson n, K. Selle n, O. Sarah n, Y. Goh n & T. Klaenhammer n

MeSH headings : Animals; Cells, Cultured; Chromatography, Liquid; Dendritic Cells / drug effects; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / immunology; Mass Spectrometry; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Probiotics and Fermented Foods; Bacterial Genetics and Biotechnology; Antimicrobial Peptides and Activities
TL;DR: P phenotypic characterization of the deletion mutant demonstrated that the SLAP LBA1029 contributes to a pro-inflammatory TNF-α response from murine DCs, and appears to impart important surface display features and immunological properties to microbes that are coated by S-layers. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 article

Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus

O'Flaherty, S., & Klaenhammer, T. R. (2012, May 5). Applied and Environmental Microbiology.

By: S. O'Flaherty n & T. Klaenhammer n

MeSH headings : Caco-2 Cells; Epithelial Cells / immunology; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Flagellin / metabolism; Flagellin / pharmacology; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Intestines / immunology; Intestines / microbiology; Lactobacillus acidophilus / immunology; Molecular Sequence Data; NF-kappa B / genetics; NF-kappa B / metabolism; Probiotics / pharmacology; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Time Factors
topics (OpenAlex): Probiotics and Fermented Foods; Immune Response and Inflammation; Gut microbiota and health
TL;DR: Analysis of global temporal gene expression by human intestinal cells when exposed to Lactobacillus acidophilus revealed induction of immune-related pathways and NF-κB target genes after a 1-h exposure, compared to a 4- or 8-H exposure. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 article

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

Mohamadzadeh, M., Pfeiler, E. A., Brown, J. B., Zadeh, M., Gramarossa, M., Managlia, E., … Klaenhammer, T. R. (2011, January 31). Proceedings of the National Academy of Sciences.

By: M. Mohamadzadeh *, E. Pfeiler n, J. Brown *, M. Zadeh *, M. Gramarossa*, E. Managlia*, P. Bere*, B. Sarraj* ...

author keywords: antiinflammatory; lactobacilli; Toll-like receptor 2; innate immunity
MeSH headings : Animals; Autoimmunity / immunology; CD4-Positive T-Lymphocytes / immunology; Colitis / chemically induced; Colitis / immunology; Colitis / microbiology; DNA Primers / genetics; Dextran Sulfate / toxicity; Flow Cytometry; Fluorescent Antibody Technique; Gene Deletion; Gene Expression Regulation / immunology; Homeodomain Proteins / genetics; Interleukin-10 / genetics; Lactobacillus acidophilus / metabolism; Lipopolysaccharides / deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / genetics; Polymerase Chain Reaction; Teichoic Acids; Transferases (Other Substituted Phosphate Groups) / genetics
topics (OpenAlex): Probiotics and Fermented Foods; Immune Response and Inflammation; Gut microbiota and health
TL;DR: Directed alteration of cell surface components of L. acidophilus NCFM establishes a potential strategy for the treatment of inflammatory intestinal disorders and significantly mitigated dextran sulfate sodium and CD4+CD45RBhighT cell-induced colitis. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 article

Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9

Goh, Y. J., Goin, C., Sarah, O. F., Altermann, E., & Hutkins, R. (2011, August 30). Microbial Cell Factories.

By: Y. Goh*, C. Goin*, O. Sarah n, E. Altermann * & R. Hutkins *

MeSH headings : Animals; Cattle; Computational Biology; Dairy Products / microbiology; Genomics; Humans; Lactic Acid / metabolism; Milk / microbiology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / metabolism
topics (OpenAlex): Probiotics and Fermented Foods; Genomics and Phylogenetic Studies; Bacteriophages and microbial interactions
TL;DR: The genome of S. thermophilus LMD-9 is shaped by its domestication in the dairy environment, with gene features that conferred rapid growth in milk, stress response mechanisms and host defense systems that are relevant to its industrial applications. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2011 article

The Impact of Omic Technologies on the Study of Food Microbes

O'Flaherty, S., & Klaenhammer, T. R. (2011, April 10). Annual Review of Food Science and Technology.

By: S. O'Flaherty n & T. Klaenhammer n

author keywords: sequencing; genome; probiotic; pathogen; microbiome; transcriptome
MeSH headings : Animals; Bioengineering; Food Microbiology / methods; Foodborne Diseases / prevention & control; Gene Expression Profiling; Genomics / methods; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / genetics; Gram-Negative Bacteria / isolation & purification; Gram-Negative Bacteria / metabolism; Gram-Positive Bacteria / classification; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / isolation & purification; Gram-Positive Bacteria / metabolism; High-Throughput Nucleotide Sequencing; Humans; Metagenomics / methods; Molecular Typing; Proteomics / methods; Transcriptome
topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Advanced Chemical Sensor Technologies
TL;DR: This review outlines advances in omic technologies and how these have impacted food microbiology through providing examples of recently published landmark work. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 article

Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells

O'Flaherty, S. J., & Klaenhammer, T. R. (2010, September 10). Microbiology.

By: S. O'Flaherty n & T. Klaenhammer n

MeSH headings : Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Caco-2 Cells; Cell Wall / metabolism; Gene Deletion; Humans; Intestines / microbiology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mutation; Stress, Physiological
topics (OpenAlex): Probiotics and Fermented Foods; Bacteriophages and microbial interactions; Bacterial Genetics and Biotechnology
TL;DR: Results indicate a role for LBA649 in stress tolerance, cell wall division and adherence to Caco-2 cells in L. acidophilus NCFM. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 article

Development and Application of a upp -Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM

Goh, Y. J., Azcárate-Peril, M. A., O'Flaherty, S., Durmaz, E., Valence, F., Jardin, J., … Klaenhammer, T. R. (2009, March 21). Applied and Environmental Microbiology.

By: Y. Goh n, M. Azcárate-Peril n, S. O'Flaherty n, E. Durmaz n, F. Valence *, J. Jardin *, S. Lortal*, T. Klaenhammer n

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
topics (OpenAlex): Probiotics and Fermented Foods; Bacteriophages and microbial interactions; Bacterial Genetics and Biotechnology
TL;DR: Use of the upp-encoded uracil phosphoribosyltransferase (UPRTase) of L. acidophilus NCFM was explored as a counterselection marker to positively select for recombinants that have resolved from chromosomal integration of pORI-based plasmids. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 article

The role and potential of probiotic bacteria in the gut, and the communication between gut microflora and gut/host

O'Flaherty, S., & Klaenhammer, T. R. (2009, December 7). International Dairy Journal.

By: S. O'Flaherty n & T. Klaenhammer n

topics (OpenAlex): Gut microbiota and health; Probiotics and Fermented Foods; Clostridium difficile and Clostridium perfringens research
TL;DR: This review outlines the recent important advances in this exciting area of research, which has led to a greater understanding of the critical interface between gut microbiota, probiotic bacteria and the host. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 article

Analysis of the Genome Sequence ofLactobacillus gasseriATCC 33323 Reveals the Molecular Basis of an Autochthonous Intestinal Organism

Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, June 7). Applied and Environmental Microbiology, Vol. 74, pp. 4610–4625.

By: M. Azcarate-Peril  n, E. Altermann n, Y. Goh n, R. Tallon n, R. Sanozky-Dawes n, E. Pfeiler n, S. O'Flaherty n, B. Buck n ...

MeSH headings : Adult; Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Child; DNA Primers; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Infant, Newborn; Intestines / microbiology; Lactobacillus / genetics; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Open Reading Frames
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: The results from this study indicated high intraspecies variability from a genome encoding traits important for survival and retention in the gastrointestinal tract. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 article

Functional Genomics of Probiotic Lactobacilli

Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September 1). Journal of Clinical Gastroenterology, Vol. 42, pp. S160–S162.

By: T. Klaenhammer n, E. Altermann n, E. Pfeiler n, B. Buck n, Y. Goh n, S. O'Flaherty n, R. Barrangou n , T. Duong n

author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Evolution, Molecular; Genome, Bacterial; Genomics; Humans; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / physiology; Probiotics / metabolism; Species Specificity
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: A comparative genomic analysis of 4 completely sequenced Lactobacillus strains versus 25 lactic acid bacterial genomes present in the public database at thetime of analysis is conducted. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2008 article

Genome-scale analyses of health-promoting bacteria: probiogenomics

Ventura, M., O'Flaherty, S., Claesson, M. J., Turroni, F., Klaenhammer, T. R., Sinderen, D., & O'Toole, P. W. (2008, November 24). Nature Reviews Microbiology.

By: M. Ventura *, S. O'Flaherty n, M. Claesson *, F. Turroni *, T. Klaenhammer n, D. Sinderen *, P. O'Toole *

MeSH headings : Bifidobacterium / genetics; Bifidobacterium / metabolism; Genomics; Humans; Lactobacillus / genetics; Lactobacillus / metabolism; Probiotics
topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Microbial Metabolites in Food Biotechnology
TL;DR: The application of probiogenomics in the elucidation of the molecular basis of probiosis is discussed using the well-recognized model probiotic bacteria genera Bifidobacterium and Lactobacillus as examples. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2026) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.