Sarah Josephine O'Flaherty
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Works (27)
Updated: July 20th, 2023 21:17
2023 article
Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut
Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). NATURE MICROBIOLOGY, Vol. 3.
MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
www.nature.com (publisher PDF)
Sources: Web Of Science, ORCID
Added: April 4, 2023
2023 journal article
Impact of Pomegranate on Probiotic Growth, Viability, Transcriptome and Metabolism
MICROORGANISMS, 11(2).
author keywords: probiotic; prebiotic; pomegranate; lactobacilli; transcriptomic
Sources: Web Of Science, ORCID
Added: February 7, 2023
2022 journal article
Metabolomic Analysis of Lactobacillus acidophilus, L. gasseri, L. crispatus, and Lacticaseibacillus rhamnosus Strains in the Presence of Pomegranate Extract
FRONTIERS IN MICROBIOLOGY, 13.
author keywords: metabolomics; Lactobacillus; probiotic; pomegranate extract; prebiotic
Sources: Web Of Science, ORCID
Added: June 13, 2022
2021 journal article
Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6).
author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
Sources: Web Of Science, ORCID
Added: February 2, 2021
2020 journal article
Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface
FRONTIERS IN MICROBIOLOGY, 11.
author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
Sources: Web Of Science, ORCID
Added: April 27, 2020
2019 journal article
Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract
PLOS PATHOGENS, 15(3).
Ed(s): L. Knoll
MeSH headings : Amidohydrolases / metabolism; Amidohydrolases / physiology; Bile Acids and Salts / metabolism; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract; Host Microbial Interactions / physiology; Humans
Sources: Web Of Science, ORCID
Added: April 15, 2019
2018 journal article
The Lactobacillus Bile Salt Hydrolase Repertoire Reveals Niche-Specific Adaptation
MSPHERE, 3(3).
Ed(s): C. Ellermeier
author keywords: Lactobacillus; bile acid; bile salt hydrolase; gastrointestinal tract; niche; penicillin V acylase; probiotic; therapeutic
MeSH headings : Adaptation, Biological; Amidohydrolases / genetics; Genetic Variation; Genotype; Lactobacillus / classification; Lactobacillus / enzymology; Lactobacillus / genetics; Penicillin Amidase / genetics; Phylogeny; Sequence Homology
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 review
CRISPR-based engineering of next-generation lactic acid bacteria
[Review of ]. CURRENT OPINION IN MICROBIOLOGY, 37, 79–87.
MeSH headings : Bifidobacterium / genetics; Bifidobacterium / physiology; CRISPR-Cas Systems; Food Microbiology / methods; Gene Editing; Humans; Lactobacillus / genetics; Lactobacillus / physiology; Metabolic Engineering; Probiotics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus
Frontiers in Microbiology, 8.
Sources: NC State University Libraries, ORCID
Added: August 6, 2018
2017 journal article
Investigating the Effect of Growth Phase on the Surface-Layer Associated Proteome of Lactobacillus acidophilus Using Quantitative Proteomics
FRONTIERS IN MICROBIOLOGY, 8.
author keywords: Lactobacillus; probiotic; cell surface; S-layer; quantitative proteomics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2017 journal article
The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM
FRONTIERS IN MICROBIOLOGY, 8.
author keywords: serine protease; S-layer; S-layer associated proteins; Lactobacillus; probiotic; intestinal barrier integrity; mucin; fibronectin
Sources: Web Of Science, ORCID
Added: August 6, 2018
2016 journal article
Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic
PROTEOMICS, 16(9), 1361–1375.
author keywords: Adhesion; HT-29 cells; Moonlighting proteins; Probiotics; Raffinose; Surface and whole cell proteomes
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Multivalent Chromosomal Expression of the Clostridium botulinum Serotype A Neurotoxin Heavy-Chain Antigen and the Bacillus anthracis Protective Antigen in Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(20), 6091–6101.
MeSH headings : Anthrax / microbiology; Anthrax / prevention & control; Bacillus anthracis / genetics; Bacillus anthracis / metabolism; Bacterial Vaccines / genetics; Bacterial Vaccines / metabolism; Botulinum Toxins, Type A / genetics; Botulinum Toxins, Type A / metabolism; Botulism / microbiology; Botulism / prevention & control; Chromosomes, Bacterial / genetics; Chromosomes, Bacterial / metabolism; Clostridium botulinum / genetics; Clostridium botulinum / metabolism; Gene Expression; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism
Source: Web Of Science
Added: August 6, 2018
2015 journal article
Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri
MICROBIOLOGY-SGM, 161, 1752–1761.
MeSH headings : Base Sequence; CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats; Gene Order; Genome, Bacterial; Lactobacillus / genetics; Molecular Sequence Data; Plasmids / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018
2015 article
Sortase-deficient lactobacilli: effect on immunomodulation and gut retention
Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & O'Flaherty, S. (2015, February). MICROBIOLOGY-SGM, Vol. 161, pp. 311–321.
MeSH headings : Aminoacyltransferases / genetics; Aminoacyltransferases / immunology; Aminoacyltransferases / metabolism; Animals; Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Proteins / metabolism; Caco-2 Cells; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / immunology; Cysteine Endopeptidases / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Gastrointestinal Tract / immunology; Gastrointestinal Tract / microbiology; Humans; Immunomodulation; Lactobacillus / enzymology; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / physiology; Mice; Swine; Tumor Necrosis Factor-alpha / immunology
Source: Web Of Science
Added: August 6, 2018
2014 journal article
Probiotic-mediated modulation of host gene expression
Interactive Probiotics, 81–98.
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM
MICROBIOLOGY-SGM, 159, 2269–2282.
MeSH headings : Animals; Cells, Cultured; Chromatography, Liquid; Dendritic Cells / drug effects; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / immunology; Mass Spectrometry; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Tumor Necrosis Factor-alpha / metabolism
Source: Web Of Science
Added: August 6, 2018
2012 journal article
Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(14), 5028–5032.
MeSH headings : Caco-2 Cells; Epithelial Cells / immunology; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Flagellin / metabolism; Flagellin / pharmacology; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Intestines / immunology; Intestines / microbiology; Lactobacillus acidophilus / immunology; Molecular Sequence Data; NF-kappa B / genetics; NF-kappa B / metabolism; Probiotics / pharmacology; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Time Factors
Source: Web Of Science
Added: August 6, 2018
2011 journal article
Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 4623–4630.
author keywords: antiinflammatory; lactobacilli; Toll-like receptor 2; innate immunity
MeSH headings : Animals; Autoimmunity / immunology; CD4-Positive T-Lymphocytes / immunology; Colitis / chemically induced; Colitis / immunology; Colitis / microbiology; DNA Primers / genetics; Dextran Sulfate / toxicity; Flow Cytometry; Fluorescent Antibody Technique; Gene Deletion; Gene Expression Regulation / immunology; Homeodomain Proteins / genetics; Interleukin-10 / genetics; Lactobacillus acidophilus / metabolism; Lipopolysaccharides / deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / genetics; Polymerase Chain Reaction; Teichoic Acids; Transferases (Other Substituted Phosphate Groups) / genetics
Source: Web Of Science
Added: August 6, 2018
2011 article
Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9
Goh, Y. J., Goin, C., O'Flaherty, S., Altermann, E., & Hutkins, R. (2011, August 30). MICROBIAL CELL FACTORIES, Vol. 10.
MeSH headings : Animals; Cattle; Computational Biology; Dairy Products / microbiology; Genomics; Humans; Lactic Acid / metabolism; Milk / microbiology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / metabolism
Source: Web Of Science
Added: August 6, 2018
2011 article
The Impact of Omic Technologies on the Study of Food Microbes
ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2, Vol. 2, pp. 353–371.
author keywords: sequencing; genome; probiotic; pathogen; microbiome; transcriptome
MeSH headings : Animals; Bioengineering; Food Microbiology / methods; Foodborne Diseases / prevention & control; Gene Expression Profiling; Genomics / methods; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / genetics; Gram-Negative Bacteria / isolation & purification; Gram-Negative Bacteria / metabolism; Gram-Positive Bacteria / classification; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / isolation & purification; Gram-Positive Bacteria / metabolism; High-Throughput Nucleotide Sequencing; Humans; Metagenomics / methods; Molecular Typing; Proteomics / methods; Transcriptome
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells
MICROBIOLOGY-SGM, 156, 3360–3367.
MeSH headings : Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Caco-2 Cells; Cell Wall / metabolism; Gene Deletion; Humans; Intestines / microbiology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mutation; Stress, Physiological
Source: Web Of Science
Added: August 6, 2018
2010 article
The role and potential of probiotic bacteria in the gut, and the communication between gut microflora and gut/host
O'Flaherty, S., & Klaenhammer, T. R. (2010, April). INTERNATIONAL DAIRY JOURNAL, Vol. 20, pp. 262–268.
Source: Web Of Science
Added: August 6, 2018
2009 journal article
Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105.
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
Source: Web Of Science
Added: August 6, 2018
2009 review
Genome-scale analyses of health-promoting bacteria: probiogenomics
[Review of ]. NATURE REVIEWS MICROBIOLOGY, 7(1), 61–U77.
MeSH headings : Bifidobacterium / genetics; Bifidobacterium / metabolism; Genomics; Humans; Lactobacillus / genetics; Lactobacillus / metabolism; Probiotics
Source: Web Of Science
Added: August 6, 2018
2008 article
Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism
Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625.
MeSH headings : Adult; Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Child; DNA Primers; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Infant, Newborn; Intestines / microbiology; Lactobacillus / genetics; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Open Reading Frames
Sources: Web Of Science, ORCID
Added: August 6, 2018
2008 article
Functional genomics of probiotic Lactobacilli
Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162.
author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Evolution, Molecular; Genome, Bacterial; Genomics; Humans; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / physiology; Probiotics / metabolism; Species Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018
