Works (27)

Updated: July 20th, 2023 21:17

2023 article

Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut

Foley, M. H., Walker, M. E., Stewart, A. K., O'Flaherty, S., Gentry, E. C., Patel, S., … Theriot, C. M. (2023, March 13). NATURE MICROBIOLOGY, Vol. 3.

By: M. Foley n, M. Walker*, A. Stewart n, S. O'Flaherty n, E. Gentry*, S. Patel*, V. Beaty*, G. Allen n ...

MeSH headings : Animals; Mice; Humans; Clostridioides difficile; Clostridioides; Bile Acids and Salts; Amidohydrolases; Clostridium Infections
Sources: Web Of Science, ORCID
Added: April 4, 2023

2023 journal article

Impact of Pomegranate on Probiotic Growth, Viability, Transcriptome and Metabolism

MICROORGANISMS, 11(2).

By: S. O'Flaherty n, N. Cobian n & R. Barrangou n

author keywords: probiotic; prebiotic; pomegranate; lactobacilli; transcriptomic
Sources: Web Of Science, ORCID
Added: February 7, 2023

2022 journal article

Metabolomic Analysis of Lactobacillus acidophilus, L. gasseri, L. crispatus, and Lacticaseibacillus rhamnosus Strains in the Presence of Pomegranate Extract

FRONTIERS IN MICROBIOLOGY, 13.

By: M. Chamberlain n, S. O'Flaherty n, N. Cobian n & R. Barrangou n

author keywords: metabolomics; Lactobacillus; probiotic; pomegranate extract; prebiotic
Sources: Web Of Science, ORCID
Added: June 13, 2022

2021 journal article

Lactobacillus bile salt hydrolase substrate specificity governs bacterial fitness and host colonization

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 118(6).

By: M. Foley n, S. O'Flaherty n, G. Allen n, A. Rivera n, A. Stewart n, R. Barrangou n, C. Theriot n

author keywords: Lactobacillus; Acidophilus; gasseri; bile salt hydrolase; bile acid
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Ecosystem; Gastrointestinal Microbiome / genetics; Gastrointestinal Microbiome / physiology; Genetic Fitness / genetics; Host-Pathogen Interactions / genetics; Humans; Lactobacillus / enzymology; Lactobacillus / genetics; Probiotics / pharmacology; Substrate Specificity / genetics
Sources: Web Of Science, ORCID
Added: February 2, 2021

2020 journal article

Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface

FRONTIERS IN MICROBIOLOGY, 11.

By: C. Klotz n, Y. Goh n, S. O'Flaherty n, B. Johnson n & R. Barrangou n

author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
Sources: Web Of Science, ORCID
Added: April 27, 2020

2019 journal article

Bile salt hydrolases: Gatekeepers of bile acid metabolism and host-microbiome crosstalk in the gastrointestinal tract

PLOS PATHOGENS, 15(3).

By: M. Foley*, S. O'Flaherty*, R. Barrangou* & C. Theriot*

Ed(s): L. Knoll

MeSH headings : Amidohydrolases / metabolism; Amidohydrolases / physiology; Bile Acids and Salts / metabolism; Gastrointestinal Microbiome / physiology; Gastrointestinal Tract; Host Microbial Interactions / physiology; Humans
Sources: Web Of Science, ORCID
Added: April 15, 2019

2018 journal article

The Lactobacillus Bile Salt Hydrolase Repertoire Reveals Niche-Specific Adaptation

MSPHERE, 3(3).

By: S. O'Flaherty n, A. Crawley n, C. Theriot n & R. Barrangou n

Ed(s): C. Ellermeier

author keywords: Lactobacillus; bile acid; bile salt hydrolase; gastrointestinal tract; niche; penicillin V acylase; probiotic; therapeutic
MeSH headings : Adaptation, Biological; Amidohydrolases / genetics; Genetic Variation; Genotype; Lactobacillus / classification; Lactobacillus / enzymology; Lactobacillus / genetics; Penicillin Amidase / genetics; Phylogeny; Sequence Homology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 review

CRISPR-based engineering of next-generation lactic acid bacteria

[Review of ]. CURRENT OPINION IN MICROBIOLOGY, 37, 79–87.

By: C. Hidalgo-Cantabrana n, S. O'Flaherty n & R. Barrangou n

MeSH headings : Bifidobacterium / genetics; Bifidobacterium / physiology; CRISPR-Cas Systems; Food Microbiology / methods; Gene Editing; Humans; Lactobacillus / genetics; Lactobacillus / physiology; Metabolic Engineering; Probiotics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus

Frontiers in Microbiology, 8.

Sources: NC State University Libraries, ORCID
Added: August 6, 2018

2017 journal article

Investigating the Effect of Growth Phase on the Surface-Layer Associated Proteome of Lactobacillus acidophilus Using Quantitative Proteomics

FRONTIERS IN MICROBIOLOGY, 8.

By: C. Klotz n, S. O'Flaherty n, Y. Goh n & R. Barrangou n

author keywords: Lactobacillus; probiotic; cell surface; S-layer; quantitative proteomics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM

FRONTIERS IN MICROBIOLOGY, 8.

By: B. Johnson n, S. O'Flaherty n, Y. Goh n, I. Carroll*, R. Barrangou n & T. Klaenhammer n

author keywords: serine protease; S-layer; S-layer associated proteins; Lactobacillus; probiotic; intestinal barrier integrity; mucin; fibronectin
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Differential proteome and cellular adhesion analyses of the probiotic bacterium Lactobacillus acidophilus NCFM grown on raffinose - an emerging prebiotic

PROTEOMICS, 16(9), 1361–1375.

By: H. Celebioglu*, M. Ejby*, A. Majumder*, C. Kobler*, Y. Goh n, K. Thorsen*, B. Schmidt*, S. O'Flaherty n ...

author keywords: Adhesion; HT-29 cells; Moonlighting proteins; Probiotics; Raffinose; Surface and whole cell proteomes
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Multivalent Chromosomal Expression of the Clostridium botulinum Serotype A Neurotoxin Heavy-Chain Antigen and the Bacillus anthracis Protective Antigen in Lactobacillus acidophilus

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(20), 6091–6101.

By: S. O'Flaherty n & T. Klaenhammer n

MeSH headings : Anthrax / microbiology; Anthrax / prevention & control; Bacillus anthracis / genetics; Bacillus anthracis / metabolism; Bacterial Vaccines / genetics; Bacterial Vaccines / metabolism; Botulinum Toxins, Type A / genetics; Botulinum Toxins, Type A / metabolism; Botulism / microbiology; Botulism / prevention & control; Chromosomes, Bacterial / genetics; Chromosomes, Bacterial / metabolism; Clostridium botulinum / genetics; Clostridium botulinum / metabolism; Gene Expression; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Occurrence and activity of a type II CRISPR-Cas system in Lactobacillus gasseri

MICROBIOLOGY-SGM, 161, 1752–1761.

By: R. Sanozky-Dawes n, K. Selle n, S. O'Flaherty n, T. Klaenhammer n & R. Barrangou n

MeSH headings : Base Sequence; CRISPR-Cas Systems / genetics; Clustered Regularly Interspaced Short Palindromic Repeats; Gene Order; Genome, Bacterial; Lactobacillus / genetics; Molecular Sequence Data; Plasmids / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 article

Sortase-deficient lactobacilli: effect on immunomodulation and gut retention

Call, E. K., Goh, Y. J., Selle, K., Klaenhammer, T. R., & O'Flaherty, S. (2015, February). MICROBIOLOGY-SGM, Vol. 161, pp. 311–321.

By: E. Call n, Y. Goh n, K. Selle n, T. Klaenhammer n & S. O'Flaherty n

MeSH headings : Aminoacyltransferases / genetics; Aminoacyltransferases / immunology; Aminoacyltransferases / metabolism; Animals; Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / immunology; Bacterial Proteins / metabolism; Caco-2 Cells; Cysteine Endopeptidases / genetics; Cysteine Endopeptidases / immunology; Cysteine Endopeptidases / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Gastrointestinal Tract / immunology; Gastrointestinal Tract / microbiology; Humans; Immunomodulation; Lactobacillus / enzymology; Lactobacillus / genetics; Lactobacillus / growth & development; Lactobacillus / physiology; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / physiology; Mice; Swine; Tumor Necrosis Factor-alpha / immunology
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Probiotic-mediated modulation of host gene expression

Interactive Probiotics, 81–98.

By: S. O'Flaherty

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM

MICROBIOLOGY-SGM, 159, 2269–2282.

By: B. Johnson n, K. Selle n, S. O'Flaherty n, Y. Goh n & T. Klaenhammer n

MeSH headings : Animals; Cells, Cultured; Chromatography, Liquid; Dendritic Cells / drug effects; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / immunology; Mass Spectrometry; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Tumor Necrosis Factor-alpha / metabolism
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Influence of Exposure Time on Gene Expression by Human Intestinal Epithelial Cells Exposed to Lactobacillus acidophilus

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 78(14), 5028–5032.

By: S. O'Flaherty n & T. Klaenhammer n

MeSH headings : Caco-2 Cells; Epithelial Cells / immunology; Epithelial Cells / metabolism; Epithelial Cells / microbiology; Flagellin / metabolism; Flagellin / pharmacology; Gene Expression Profiling; Gene Expression Regulation; Humans; Intestinal Mucosa / metabolism; Intestines / cytology; Intestines / immunology; Intestines / microbiology; Lactobacillus acidophilus / immunology; Molecular Sequence Data; NF-kappa B / genetics; NF-kappa B / metabolism; Probiotics / pharmacology; Recombinant Proteins / metabolism; Recombinant Proteins / pharmacology; Time Factors
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 108, 4623–4630.

By: M. Mohamadzadeh*, E. Pfeiler n, J. Brown*, M. Zadeh, M. Gramarossa*, E. Managlia*, P. Bere*, B. Sarraj* ...

author keywords: antiinflammatory; lactobacilli; Toll-like receptor 2; innate immunity
MeSH headings : Animals; Autoimmunity / immunology; CD4-Positive T-Lymphocytes / immunology; Colitis / chemically induced; Colitis / immunology; Colitis / microbiology; DNA Primers / genetics; Dextran Sulfate / toxicity; Flow Cytometry; Fluorescent Antibody Technique; Gene Deletion; Gene Expression Regulation / immunology; Homeodomain Proteins / genetics; Interleukin-10 / genetics; Lactobacillus acidophilus / metabolism; Lipopolysaccharides / deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88 / genetics; Polymerase Chain Reaction; Teichoic Acids; Transferases (Other Substituted Phosphate Groups) / genetics
Source: Web Of Science
Added: August 6, 2018

2011 article

Specialized adaptation of a lactic acid bacterium to the milk environment: the comparative genomics of Streptococcus thermophilus LMD-9

Goh, Y. J., Goin, C., O'Flaherty, S., Altermann, E., & Hutkins, R. (2011, August 30). MICROBIAL CELL FACTORIES, Vol. 10.

By: Y. Goh n, C. Goin*, S. O'Flaherty n, E. Altermann* & R. Hutkins*

MeSH headings : Animals; Cattle; Computational Biology; Dairy Products / microbiology; Genomics; Humans; Lactic Acid / metabolism; Milk / microbiology; Streptococcus thermophilus / genetics; Streptococcus thermophilus / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 article

The Impact of Omic Technologies on the Study of Food Microbes

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 2, Vol. 2, pp. 353–371.

By: S. O'Flaherty n & T. Klaenhammer n

author keywords: sequencing; genome; probiotic; pathogen; microbiome; transcriptome
MeSH headings : Animals; Bioengineering; Food Microbiology / methods; Foodborne Diseases / prevention & control; Gene Expression Profiling; Genomics / methods; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / genetics; Gram-Negative Bacteria / isolation & purification; Gram-Negative Bacteria / metabolism; Gram-Positive Bacteria / classification; Gram-Positive Bacteria / genetics; Gram-Positive Bacteria / isolation & purification; Gram-Positive Bacteria / metabolism; High-Throughput Nucleotide Sequencing; Humans; Metagenomics / methods; Molecular Typing; Proteomics / methods; Transcriptome
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Functional and phenotypic characterization of a protein from Lactobacillus acidophilus involved in cell morphology, stress tolerance and adherence to intestinal cells

MICROBIOLOGY-SGM, 156, 3360–3367.

By: . Sarah J. O'Flaherty & T. Klaenhammer n

MeSH headings : Bacterial Adhesion; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Caco-2 Cells; Cell Wall / metabolism; Gene Deletion; Humans; Intestines / microbiology; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / growth & development; Lactobacillus acidophilus / metabolism; Membrane Proteins / genetics; Membrane Proteins / metabolism; Mutation; Stress, Physiological
Source: Web Of Science
Added: August 6, 2018

2010 article

The role and potential of probiotic bacteria in the gut, and the communication between gut microflora and gut/host

O'Flaherty, S., & Klaenhammer, T. R. (2010, April). INTERNATIONAL DAIRY JOURNAL, Vol. 20, pp. 262–268.

By: S. O'Flaherty n & T. Klaenhammer n

Source: Web Of Science
Added: August 6, 2018

2009 journal article

Development and Application of a upp-Based Counterselective Gene Replacement System for the Study of the S-Layer Protein SlpX of Lactobacillus acidophilus NCFM

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 75(10), 3093–3105.

By: Y. Goh n, M. Azcarate-Peril n, S. O'Flaherty n, E. Durmaz n, F. Valence*, J. Jardin*, S. Lortal*, T. Klaenhammer n

MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Drug Resistance, Bacterial; Fluorouracil / pharmacology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Molecular Sequence Data; Mutagenesis, Insertional / methods; Pentosyltransferases / genetics; Pentosyltransferases / metabolism; Plasmids; Recombination, Genetic; Selection, Genetic
Source: Web Of Science
Added: August 6, 2018

2009 review

Genome-scale analyses of health-promoting bacteria: probiogenomics

[Review of ]. NATURE REVIEWS MICROBIOLOGY, 7(1), 61–U77.

MeSH headings : Bifidobacterium / genetics; Bifidobacterium / metabolism; Genomics; Humans; Lactobacillus / genetics; Lactobacillus / metabolism; Probiotics
Source: Web Of Science
Added: August 6, 2018

2008 article

Analysis of the genome sequence of Lactobacillus gasseri ATCC 33323 reveals the molecular basis of an autochthonous intestinal organism

Azcarate-Peril, M. A., Altermann, E., Goh, Y. J., Tallon, R., Sanozky-Dawes, R. B., Pfeiler, E. A., … Klaenhammer, T. R. (2008, August). APPLIED AND ENVIRONMENTAL MICROBIOLOGY, Vol. 74, pp. 4610–4625.

By: M. Azcarate-Peril n, E. Altermann n, Y. Goh n, R. Tallon n, R. Sanozky-Dawes n, E. Pfeiler n, S. O'Flaherty n, B. Buck n ...

MeSH headings : Adult; Bacterial Adhesion / genetics; Bacterial Adhesion / physiology; Bacterial Proteins / genetics; Child; DNA Primers; Gastrointestinal Tract / microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Infant, Newborn; Intestines / microbiology; Lactobacillus / genetics; Lactobacillus / isolation & purification; Lactobacillus / pathogenicity; Open Reading Frames
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 article

Functional genomics of probiotic Lactobacilli

Klaenhammer, T. R., Altermann, E., Pfeiler, E., Buck, B. L., Goh, Y.-J., O'Flaherty, S., … Duong, T. (2008, September). JOURNAL OF CLINICAL GASTROENTEROLOGY, Vol. 42, pp. S160–S162.

By: T. Klaenhammer n, E. Altermann n, E. Pfeiler n, B. Buck n, Y. Goh n, S. O'Flaherty n, R. Barrangou n, T. Duong n

author keywords: Lactobacillus acidophilus; Lactobacillus johnsonii; Lactobacillus plantarum; Lactobacillus gasseri; genomics; probiotic cultures; lactic acid bacteria
MeSH headings : Animals; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Evolution, Molecular; Genome, Bacterial; Genomics; Humans; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus / physiology; Probiotics / metabolism; Species Specificity
Sources: Web Of Science, ORCID
Added: August 6, 2018