Stephanie K. Bloom

MeSH headings : Animals; Anura / embryology; Cell Lineage; Evolution, Molecular; Genetic Variation; Intestines / embryology; Morphogenesis; Phenotype; Phylogeny; Signal Transduction; Species Specificity; Thyroid Hormones / metabolism; Tretinoin / metabolism; Xenopus laevis / embryology

TL;DR: The ancestral gut phenotype in Lepidobatrachus was recovered by performing a reverse chemical manipulation to upregulate RA signaling, providing strong evidence that modifications to this specific pathway promoted the emergence of a lineage‐specific phenotypic novelty. (via Semantic Scholar)

author keywords: gut; Xenopus; morphogenesis; endoderm, intercalation; elongation

MeSH headings : Animals; Animals, Genetically Modified; Body Patterning / genetics; Cell Polarity / genetics; Cell Shape / genetics; Embryo, Nonmammalian; Endoderm / cytology; Endoderm / embryology; Endoderm / metabolism; Gastrointestinal Diseases / congenital; Gastrointestinal Diseases / embryology; Gastrointestinal Tract / abnormalities; Gastrointestinal Tract / embryology; Gastrula / embryology; Gastrula / metabolism; Models, Biological; Morphogenesis / genetics; Nonmuscle Myosin Type IIB / genetics; Nonmuscle Myosin Type IIB / metabolism; Nonmuscle Myosin Type IIB / physiology; Signal Transduction / genetics; Xenopus / embryology; Xenopus / genetics; Xenopus / metabolism; rho-Associated Kinases / genetics; rho-Associated Kinases / metabolism; rho-Associated Kinases / physiology; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism; rhoA GTP-Binding Protein / physiology

TL;DR: The results suggest that the cellular and molecular events driving tissue elongation in the PGT are mechanistically analogous to those that function during gastrulation, but occur within a novel cylindrical geometry to generate an epithelial‐lined tube. (via Semantic Scholar)