Stephanie K. Bloom

Works (2)

Updated: July 5th, 2023 15:48

2013 journal article

Developmental origins of a novel gut morphology in frogs

EVOLUTION & DEVELOPMENT, 15(3), 213–223.

By: S. Bloom n, C. Ledon-Rettig n, C. Infante *, A. Everly*, J. Hanken * & N. Nascone-Yoder n 

MeSH headings : Animals; Anura / embryology; Cell Lineage; Evolution, Molecular; Genetic Variation; Intestines / embryology; Morphogenesis; Phenotype; Phylogeny; Signal Transduction; Species Specificity; Thyroid Hormones / metabolism; Tretinoin / metabolism; Xenopus laevis / embryology
TL;DR: The ancestral gut phenotype in Lepidobatrachus was recovered by performing a reverse chemical manipulation to upregulate RA signaling, providing strong evidence that modifications to this specific pathway promoted the emergence of a lineage‐specific phenotypic novelty. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Morphogenesis of the Primitive Gut Tube Is Generated by Rho/ROCK/Myosin II-Mediated Endoderm Rearrangements

DEVELOPMENTAL DYNAMICS, 238(12), 3111–3125.

By: R. Reed n, M. Womble n, M. Dush n, R. Tull n, S. Bloom n, A. Morckel n, E. Devlin*, N. Nascone-Yoder n 

author keywords: gut; Xenopus; morphogenesis; endoderm, intercalation; elongation
MeSH headings : Animals; Animals, Genetically Modified; Body Patterning / genetics; Cell Polarity / genetics; Cell Shape / genetics; Embryo, Nonmammalian; Endoderm / cytology; Endoderm / embryology; Endoderm / metabolism; Gastrointestinal Diseases / congenital; Gastrointestinal Diseases / embryology; Gastrointestinal Tract / abnormalities; Gastrointestinal Tract / embryology; Gastrula / embryology; Gastrula / metabolism; Models, Biological; Morphogenesis / genetics; Nonmuscle Myosin Type IIB / genetics; Nonmuscle Myosin Type IIB / metabolism; Nonmuscle Myosin Type IIB / physiology; Signal Transduction / genetics; Xenopus / embryology; Xenopus / genetics; Xenopus / metabolism; rho-Associated Kinases / genetics; rho-Associated Kinases / metabolism; rho-Associated Kinases / physiology; rhoA GTP-Binding Protein / genetics; rhoA GTP-Binding Protein / metabolism; rhoA GTP-Binding Protein / physiology
TL;DR: The results suggest that the cellular and molecular events driving tissue elongation in the PGT are mechanistically analogous to those that function during gastrulation, but occur within a novel cylindrical geometry to generate an epithelial‐lined tube. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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