Works (3)

Updated: January 3rd, 2024 05:03

2023 journal article

Allosteric site variants affect GTP hydrolysis on Ras

PROTEIN SCIENCE, 32(10).

By: C. Johnson*, S. Fetics n, K. Davis n, J. Rodrigues* & C. Mattos n

co-author countries: United States of America 🇺🇸
author keywords: allosteric site; allostery; HRAS; hydrolysis; KRAS; mutation; RAF; small GTPase
Source: Web Of Science
Added: January 2, 2024

2015 journal article

Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

STRUCTURE, 23(3), 505–516.

By: S. Fetics n, H. Guterres*, B. Kearney n, G. Buhrman n, B. Ma*, R. Nussinov*, C. Mattos n

co-author countries: Israel 🇮🇱 United States of America 🇺🇸
MeSH headings : Allosteric Regulation; Catalytic Domain; Crystallography, X-Ray; Humans; Hydrogen Bonding; Molecular Dynamics Simulation; Mutation, Missense; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; Protein Structure, Secondary; Proto-Oncogene Proteins c-raf / chemistry; Proto-Oncogene Proteins p21(ras) / chemistry; Proto-Oncogene Proteins p21(ras) / genetics
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 107(11), 4931–4936.

By: G. Buhrman n, G. Holzapfel n, S. Fetics n & C. Mattos n

co-author countries: United States of America 🇺🇸
author keywords: GTPase; Raf; calcium; intrinsic hydrolysis
MeSH headings : Acetates / pharmacology; Allosteric Regulation / drug effects; Allosteric Site; Biocatalysis / drug effects; Calcium / metabolism; Calcium Compounds / pharmacology; Catalytic Domain; Crystallography, X-Ray; Enzyme Stability / drug effects; Glutamine / metabolism; Hydrogen Bonding / drug effects; Hydrolysis / drug effects; Hydroxyl Radical / metabolism; Magnesium / metabolism; Models, Molecular; Protein Structure, Tertiary; Structure-Activity Relationship; ras Proteins / chemistry; ras Proteins / metabolism
Source: Web Of Science
Added: August 6, 2018

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